lysophosphatidic acid has been researched along with sphingosine in 141 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (0.71) | 18.2507 |
| 2000's | 77 (54.61) | 29.6817 |
| 2010's | 52 (36.88) | 24.3611 |
| 2020's | 11 (7.80) | 2.80 |
| Authors | Studies |
|---|---|
| Hall, A; Nobes, CD; Spiegel, S; Wang, F | 1 |
| Béliveau, R; Gingras, D; Langlois, S | 1 |
| Bittman, R; Li, Z; Mintzer, E | 1 |
| Barber, SC; Gampel, A; Mellor, H; Scolding, NJ | 1 |
| Deng, PF; Epstein, DL; Gawdi, G; Mettu, PS; Misra, UK; Rao, PV | 1 |
| Tokumura, A | 2 |
| Garlichs, CD; Goppelt-Struebe, M; Hinkmann, F; Muehlich, S; Schneider, N | 1 |
| Anliker, B; Chun, J | 1 |
| Darroch, PI; Kong, KC; Pyne, S | 1 |
| Ha, KS; Han, JA; Jeoung, D; Kang, YC; Kim, KM; Kim, YM; Kwon, YG; Lee, KS; Lee, SJ; Namkoong, S | 1 |
| Fells, JI; Holdsworth, G; Hutchinson, G; Milligan, G; Osborne, DA; Parrill, AL; Pham, TT | 1 |
| Avraamides, C; Gaughan, JP; Hannah, DF; Huttenlocher, A; Marcinkiewicz, C; Mosher, DF; Panetti, TS | 1 |
| Fang, X; Hasegawa, Y; Lapushin, R; Liu, S; Mills, GB; Woodgett, JR; Xu, HJ; Yu, S | 1 |
| Kitayama, J; Mori, K; Nagawa, H; Shida, D; Watanabe, T; Yamaguchi, H; Yamashita, H | 1 |
| Watsky, MA; Yin, Z | 1 |
| Logsdon, CD; Mulholland, MW; Segura, BJ; Xiao, L; Zhang, W | 1 |
| Brunswig-Spickenheier, B; Budnik, LT | 1 |
| Hammer, S; Kleuser, B; Radeke, HH; Sauer, B; Stoidtner, K; von Wenckstern, H | 1 |
| Bassa, BV; Ganji, SH; Kamanna, VS; Roh, DD | 1 |
| Christodoulou, E; Goding, JW; Kikuchi, K; Moolenaar, WH; Nagano, T; Perrakis, A; Ruurs, P; Takakusa, H; van Meeteren, LA | 1 |
| Chen, CN; Chen, JH; Lee, H; Lin, CI; Wu, WT | 1 |
| Watsky, MA; Yin, F | 1 |
| Aaronson, PI; Leach, RM; Patel, R; Snetkov, VA; Thomas, GD; Ward, JP | 1 |
| Darroch, P; Kong, KC; Ktistakis, N; Long, J; Pyne, NJ; Pyne, S; Wan, KF | 1 |
| Horiuchi, Y; Ishiuchi, S; Kurose, H; Malchinkhuu, E; Mogi, C; Ohwada, S; Okajima, F; Saito, N; Sato, K; Tomura, H | 1 |
| Chun, J | 1 |
| Rosen, H | 1 |
| Belmonte, KE; Costello, RW; Gendy, SS; Rahaman, M; Walsh, MT | 1 |
| Bae, YS; Im, DS; Jo, SH; Kim, MK; Kim, SD; Lee, HY; Park, KS; Shin, EH | 1 |
| Chun, J; Dubin, AE; Gardell, SE | 1 |
| Chen, CL; Lee, H; Pan, CY | 1 |
| Ahmad, M; Long, JS; Pyne, NJ; Pyne, S | 1 |
| Beil, M; Dao, M; Lim, CT; Micoulet, A; Mills, JP; Seufferlein, T; Spatz, J; Suresh, S | 1 |
| Chen, CN; Chen, JH; Lee, H; Lin, CI | 1 |
| Herroeder, S; Moers, A; Offermanns, S; Rieken, S; Sassmann, A; Wallenwein, B; Wettschureck, N | 1 |
| Liu, S; Mills, GB; Murph, M; Tanaka, T | 1 |
| Anthis, NJ; Davis, GE; Fisher, KE; Koh, W; Pop, A; Saunders, WB | 1 |
| Izban, MG; Jeng, YJ; Soloff, MS; Suarez, VR; Wang, HQ | 1 |
| Chun, J; Herr, DR | 1 |
| Bandle, RW; Clair, T; Hermansen, R; Koh, E; Roberts, DD; Schiffmann, E; Stracke, ML | 1 |
| Chen, CN; Lee, H; Lin, CI; Lin, PW | 1 |
| Ipatova, OM; Khalilov, EM; Kochetova, MM; Torkhovskaya, TI; Zakharova, TS | 1 |
| Bönisch, H; Brüss, M; Göthert, M; Molderings, GJ; von Kügelgen, I; Wolf, C | 1 |
| Fujii, S; Furukawa, A; Hayashi, K; Ikeda, K; Inoue, S; Kita, K; Toyomoto, M | 1 |
| Chen, YT; Pan, CY; Wu, AZ | 1 |
| Devine, K; Fishman, DA; Gil, O; Smicun, Y | 1 |
| Mills, GB; Murph, M | 1 |
| Kajiya, K; Kawamichi, H; Kishi, H; Kobayashi, S; Takada, Y; Xu, D | 2 |
| Ishiuchi, S; Kurose, H; Maehama, T; Malchinkhuu, E; Mogi, C; Okajima, F; Sato, K; Tomura, H; Yoshimoto, Y | 1 |
| Danneberg, K; Jakobs, KH; Kleuser, B; Kürschner, U; Lichte, K; Meyer zu Heringdorf, D; Rossi, R; ter Braak, M | 1 |
| Grinnell, F; Ho, CH; Jiang, H; Rhee, S | 1 |
| Giusto, NM; Pasquaré, SJ; Salvador, GA | 1 |
| Fells, JI; Fujiwara, Y; Mujahid, S; Parrill, AL; Perygin, DH; Tigyi, G; Tsukahara, R; Valentine, WJ; Van Brocklyn, JR; Yokoyama, K | 1 |
| Brinkmann, V; Lynch, KR; Moolenaar, WH; Saulnier-Blache, JS; van Meeteren, LA | 1 |
| Fujita, N; Murakami, M; Shiraishi, A; Tabata, K | 1 |
| Lynch, KR; Rivera-Lopez, CM; Tucker, AL | 1 |
| Devine, KM; Fishman, DA; Hope, JM; Smicun, Y | 1 |
| Pyne, NJ; Pyne, S | 1 |
| Bigsby, RM; Caperell-Grant, A; Liu, J; Mok, SC; Wang, D; Xu, Y; Yang, G; Zhao, Z | 1 |
| Alvarez, SE; Fang, X; Kordula, T; Lépine, S; Milstien, S; Shida, D; Spiegel, S; Takabe, K | 1 |
| Chun, J; Mutoh, T | 1 |
| Aoki, J; Arai, H; Hamada, A; Matsuda, H; Noji, S; Ohuchi, H; Takagi, A; Tanaka, M | 1 |
| Aoki, J; Arima, N; Kano, K; Kitamura, H; Makide, K | 1 |
| Caldwell, JS; Chen, YA; Chu, A; Li, W; Nguyen, DG; Otero, F; Shelton, F; Wang, B; Yin, H | 1 |
| Liebisch, G; Scherer, M; Schmitz, G | 1 |
| Peyruchaud, O | 1 |
| Carbone, LD; Kikuchi, M; Morishige, J; Postlethwaite, A; Tokumura, A; Watsky, MA; Yoshioka, Y | 1 |
| Gibbs, TC; Kipp, KR; Meier, KE; Rubio, MV; Xie, Y; Zhang, Z | 1 |
| Cheng, HY; Escalante-Alcalde, D; Federico, L; Fulkerson, Z; Miriyala, S; Morris, AJ; Panchatcharam, M; Selim, S; Smyth, SS | 1 |
| Gaveglio, VL; Giusto, NM; Pasquaré, SJ | 2 |
| Hanson, BJ; Revankar, C; Wetter, JA | 1 |
| Wang, D; Wang, Z; Xu, Y | 1 |
| Fishman, DA; Wang, F | 1 |
| Grinnell, F; Ho, CH; Rhee, S | 1 |
| Hosoya, K; Ikeda, S; Tachikawa, M; Tsuji, K | 1 |
| Morris, AJ; Salous, A; Selim, S; Smyth, SS | 1 |
| Ishiuchi, S; Kimura, T; Kurose, H; Maehama, T; Malchinkhuu, E; Mogi, C; Okajima, F; Sato, K; Tomura, H; Yoshimoto, Y | 1 |
| Colizzi, V; De Angelis, FR; De Spirito, M; Delogu, G; Fraziano, M; Greco, E; Papi, M; Sali, M; Santucci, MB | 1 |
| Jeon, JH; Kim, SJ; Min, JE; Nam, JH; Shin, DH; Ye, SK | 1 |
| Boucharaba, A; Clézardin, P; Guillet, B; Hneino, M; Menaa, F; Oliver, P; Peyruchaud, O; Philippe, C; van Wijnen, AJ | 1 |
| Iwakura, Y; Okae, H | 1 |
| Hirano, K; Koike, T; Morishige, J; Satouchi, K; Takagi, H; Tanaka, T; Urikura, M | 1 |
| Berliner, C; Bialecki, W; Kleuser, B; Leptin, J; Milićević, NM; Müller, R; Pörtner, D; Schumacher, U | 1 |
| Chun, J; Dubin, AE; Herr, DR | 1 |
| Bekele, R; Brindley, DN; Capatos, D; Samadi, N; Sariahmetoglu, M; Venkatraman, G | 1 |
| Im, DS | 1 |
| Pattanaik, D; Postlethwaite, AE | 1 |
| Nakamura, K; Yatomi, Y | 1 |
| Atiyeh, M; Costello, RW; Gleich, G; Maloney, M; Walsh, MT | 1 |
| Cabibbo, A; Colizzi, V; Delogu, G; Fadda, G; Fraziano, M; Greco, E; Mariani, F; Quintiliani, G; Rocca, S; Sali, M; Santucci, MB | 1 |
| Albright, RA; Braddock, DT; Cao, W; Chang, WC; De La Cruz, EM; Saunders, LP | 1 |
| Ahonen, I; Grafström, R; Happonen, A; Härmä, V; Kaewphan, S; Kallioniemi, O; Knuuttila, M; Kohonen, P; Kovanen, P; Lötjönen, J; Mirtti, T; Nees, M; Virtanen, J | 1 |
| Jalink, K; Jongsma, M; Matas-Rico, E; Moolenaar, WH; Rzadkowski, A | 1 |
| Bieberich, E | 1 |
| Giacomini, MM; Kudo, M; Sheppard, D; Travis, MA | 1 |
| Gellett, AM; Kharel, Y; Lynch, KR; Morris, AJ; Sunkara, M | 1 |
| Dubois, G; Pyne, NJ; Pyne, S | 1 |
| Shea, BS; Tager, AM | 1 |
| Fu, XD; Guan, KL; Jewell, JL; Li, H; Lian, I; Mills, GB; Panupinthu, N; Tumaneng, K; Wang, LH; Yu, FX; Yuan, H; Zhao, B; Zhao, J | 1 |
| Bruni, P; Cencetti, F; Donati, C | 1 |
| Bonamy, GM; DeRan, M; Liu, J; Miller, E; Peters, EC; Su, AI; Wu, C; Wu, X; Yang, J | 1 |
| Brewer, JW | 1 |
| Brown, JH; Cho, MK; Dusaban, SS; Masliah, E; Purcell, NH; Rockenstein, E; Smrcka, AV | 1 |
| Dziak, R | 1 |
| Aoki, J; Hama, K; Inoue, A; Kano, K; Kawahara, A; Nakanaga, K; Nishina, H; Saigusa, D; Sato, T; Tokuyama, H; Tomioka, Y; Yukiura, H | 1 |
| Brandon, JA; Morris, AJ; Mueller, P; Smyth, SS; Yang, F | 1 |
| Aoki, J; Kimoto, S; Morikawa, Y; Okudaira, S; Shimizu, Y; Tanaka, T; Tokumura, A | 1 |
| Fujii, T; Ichikawa, M; Iwasawa-Kawai, Y; Kawana, K; Nagamatsu, T; Osuga, Y; Schust, DJ; Yamashita, T | 1 |
| Bornkessel, F; Brünnert, D; Goyal, P; Sztachelska, M; Treder, N; Wolczynski, S; Zygmunt, M | 1 |
| Bernacchioni, C; Blescia, S; Bruni, P; Bruno, G; Cencetti, F; Donati, C | 1 |
| Birgbauer, E; Fincher, J; Whiteneck, C | 1 |
| Abu El-Asrar, AM; Alam, K; Mohammad, G; Mousa, A; Nawaz, MI; Opdenakker, G; Siddiquei, MM | 1 |
| Chun, J; Kihara, Y; Mizuno, H | 1 |
| Moolenaar, WH | 1 |
| Benesch, MG; Brindley, DN; Curtis, JM; McMullen, TP; Zhao, YY | 1 |
| Binder, BY; Leach, JK; Silva, EA; Williams, PA | 1 |
| Abdel-Latif, A; Heron, PM; Morris, AJ; Smyth, SS | 1 |
| Desai, P; Gahtan, V; Maier, KG; Siddiqui, SA; Stein, JJ | 1 |
| Brindley, DN; Curtis, JM; Dewald, J; Tang, X; Zhao, YY | 1 |
| Böttcher, A; Fischer, A; Konovalova, T; Liebisch, G; Matysik, S; Orsó, E; Schmitz, G; Tafelmeier, M | 1 |
| Bogdanov, M; Lin, Y; Lu, S; Tong, S; Wang, M; Zheng, L | 1 |
| Fleming, JK; Glass, TR; Lackie, SJ; Wojciak, JM | 1 |
| Blum, Y; Cambien, F; Civelek, M; Codoni, V; Durand, H; Gaignard, P; Iannacci, F; Karabina, SA; Lusis, AJ; Ninio, E; Proust, C; Thérond, P; Touat-Hamici, Z; Weidmann, H | 1 |
| Cenac, C; Chicanne, G; Gaits-Iacovoni, F; Gratacap, MP; Le Faouder, P; Minville, V; Mujalli, A; Payrastre, B; Severin, S; Vardon Bounes, F | 1 |
| Fang, Z; Guo, F; Jing, X; Li, G; Wang, J; Ye, Y; Yin, W; Zhu, W | 1 |
| Hisano, Y; Hla, T | 1 |
| Bonder, C; Lidgerwood, GE; Pébay, A; Pitson, SM | 1 |
| Chen, Y; Guo, J; Liu, T; Liu, Z; Meng, W; Peng, F; Peng, J; Rao, T; Tan, Z; Yu, J | 1 |
| Androsov, G; Feng, Y; Gurung, AC; Herbert, ZT; Kavanagh, TR; Mischler, WJ; Priolo, C; Sadow, PM | 1 |
| Brindley, DN; Tang, X | 1 |
| Engelbrecht, E; Hla, T; MacRae, CA | 1 |
| Zhao, J; Zhao, Y | 1 |
| Giménez-Llort, L; González de San Román, E; Llorente-Ovejero, A; Manuel, I; Martínez-Gardeazabal, J; Moreno-Rodríguez, M; Rodríguez-Puertas, R | 1 |
| Chun, J; Hite, RK; Huang, XY; Kihara, Y; Liu, S; Liu, W; Paknejad, N; Ray, M; Zhu, L | 1 |
| Hirata, N; Kanda, Y; Nishida, M; Ono, A; Yamada, S; Yanagida, S; Yasuhiko, Y | 1 |
| Aoki, J; Nishikado, S; Omi, J; Takagi, Y | 1 |
| Aihara, M; Ali, H; Azuma, M; Has, RY; Kagawa, K; Kawano, H; Koyama, K; Morito, K; Nishioka, Y; Takahashi, N; Tanaka, T | 1 |
| Aoki, J; Kano, K; Omi, J; Yaginuma, S | 1 |
42 review(s) available for lysophosphatidic acid and sphingosine
| Article | Year |
|---|---|
Metabolic pathways and physiological and pathological significances of lysolipid phosphate mediators.
Topics: Animals; Lysophospholipids; Sphingosine | 2004 |
Cell surface receptors in lysophospholipid signaling.
Topics: Animals; Lysophospholipids; Mice; Phenotype; Receptors, Lysophosphatidic Acid; Receptors, Lysosphingolipid; Signal Transduction; Sphingosine | 2004 |
Lysophosphatidic acid and sphingosine 1-phosphate biology: the role of lipid phosphate phosphatases.
Topics: Animals; Humans; Lysophospholipids; Membrane Proteins; Phosphatidate Phosphatase; Phosphoric Monoester Hydrolases; Protein Structure, Tertiary; Receptors, G-Protein-Coupled; Sphingosine | 2004 |
Bioactive lysophospholipids and mesangial cell intracellular signaling pathways: role in the pathobiology of kidney disease.
Topics: Animals; Cell Proliferation; Glomerular Mesangium; Humans; Kidney Diseases; Lysophosphatidylcholines; Lysophospholipids; Models, Biological; Phosphorylcholine; Receptors, Lysophosphatidic Acid; Receptors, Lysophospholipid; Signal Transduction; Sphingosine | 2005 |
Lysophospholipids in the nervous system.
Topics: Animals; Humans; Kinetics; Lipids; Lysophospholipids; Nervous System; Signal Transduction; Sphingosine | 2005 |
Chemical approaches to the lysophospholipid receptors.
Topics: Animals; GTP-Binding Proteins; Humans; Ligands; Lysophospholipids; Protein Binding; Receptors, G-Protein-Coupled; Receptors, Lysophospholipid; Sphingosine | 2005 |
Emerging medicinal roles for lysophospholipid signaling.
Topics: Animals; Autoimmune Diseases; Cardiovascular Diseases; Humans; Lysophospholipids; Neoplasms; Obesity; Phosphorylation; Receptors, G-Protein-Coupled; Receptors, Lysophosphatidic Acid; Receptors, Lysosphingolipid; Signal Transduction; Sphingosine; Transplantation Immunology | 2006 |
Connections between single-cell biomechanics and human disease states: gastrointestinal cancer and malaria.
Topics: Animals; Biomechanical Phenomena; Cell Line, Tumor; Elasticity; Erythrocyte Deformability; Erythrocytes; Gastrointestinal Neoplasms; Humans; In Vitro Techniques; Lysophospholipids; Malaria; Pancreatic Neoplasms; Phosphorylcholine; Plasmodium falciparum; Sphingosine | 2005 |
Of spiders and crabs: the emergence of lysophospholipids and their metabolic pathways as targets for therapy in cancer.
Topics: Animals; Drug Delivery Systems; Humans; Lysophospholipids; Metabolic Networks and Pathways; Models, Biological; Neoplasms; Receptors, Lysophosphatidic Acid; Receptors, Lysosphingolipid; Sphingosine | 2006 |
[Phosphodiesterases that extracellularly produces a lysolipid mediator].
Topics: Animals; Ascitic Fluid; Cardiovascular System; Endothelial Cells; Extracellular Space; Humans; Kidney Tubules, Proximal; Lysophospholipids; Phosphoric Diester Hydrolases; Reproduction; Saliva; Sphingosine | 2006 |
Effects of LPA and S1P on the nervous system and implications for their involvement in disease.
Topics: Animals; Humans; Lysophospholipids; Nervous System; Nervous System Diseases; Sphingosine | 2007 |
Lysophospholipid receptors in cell signaling.
Topics: Female; Humans; Lysophospholipids; Male; Models, Biological; Receptors, G-Protein-Coupled; Receptors, Lysophospholipid; Signal Transduction; Sphingosine | 2007 |
Targeting the lipids LPA and S1P and their signalling pathways to inhibit tumour progression.
Topics: Disease Progression; Drug Delivery Systems; Lysophospholipids; Neoplasms; Signal Transduction; Sphingosine; Treatment Outcome | 2007 |
Sphingosine 1-phosphate, lysophosphatidic acid and growth factor signaling and termination.
Topics: Animals; Humans; Intercellular Signaling Peptides and Proteins; Lysophospholipids; Protein Binding; Receptor Protein-Tyrosine Kinases; Signal Transduction; Sphingosine | 2008 |
Lysophospholipid activation of G protein-coupled receptors.
Topics: Animals; Asthma; Autoimmune Diseases; Cardiovascular Diseases; Cell Adhesion; Cell Movement; Cell Proliferation; Cell Survival; Gap Junctions; Humans; Immunologic Factors; Lysophospholipids; Neoplasms; Receptors, G-Protein-Coupled; Receptors, Lysosphingolipid; Signal Transduction; Sphingosine | 2008 |
[Lysophospholipid mediators].
Topics: Animals; Cell Physiological Phenomena; Drug Design; Fingolimod Hydrochloride; Humans; Immunosuppressive Agents; Inflammation; Insulin; Insulin Secretion; Lysophospholipids; Neurotransmitter Agents; Propylene Glycols; Receptors, G-Protein-Coupled; Sphingosine | 2009 |
Novel implications for lysophospholipids, lysophosphatidic acid and sphingosine 1-phosphate, as drug targets in cancer.
Topics: Fingolimod Hydrochloride; Humans; Lysophospholipids; Neoplasms; Propylene Glycols; Receptors, Lysophosphatidic Acid; Receptors, Lysosphingolipid; Sphingosine | 2009 |
Regulation of blood and vascular cell function by bioactive lysophospholipids.
Topics: Blood Vessels; Cardiovascular Diseases; Homeostasis; Humans; Lysophospholipids; Sphingosine | 2009 |
Lipid generation and signaling in ovarian cancer.
Topics: Antineoplastic Agents; Cell Hypoxia; Drug Delivery Systems; Female; Forecasting; Humans; Lysophospholipids; Multienzyme Complexes; Neoplasm Proteins; Ovarian Neoplasms; Phosphodiesterase I; Phospholipases A2; Phospholipases A2, Cytosolic; Phosphoric Diester Hydrolases; Pyrophosphatases; Receptors, Lysophosphatidic Acid; Signal Transduction; Sphingosine | 2009 |
Lysophosphatidic acid and invasion.
Topics: Animals; Antineoplastic Agents; Cell Hypoxia; Cyclooxygenase 2; Diterpenes; Female; Humans; Interleukins; Intracellular Signaling Peptides and Proteins; Lysophospholipids; Membrane Lipids; Mice; Multienzyme Complexes; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Proteins; Neovascularization, Pathologic; Ovarian Neoplasms; Peptide Hydrolases; Phosphodiesterase I; Phospholipases A; Phosphoric Diester Hydrolases; Pyrophosphatases; Receptors, Lysophosphatidic Acid; Signal Transduction; Sphingosine; Vascular Endothelial Growth Factor A | 2009 |
Blood relatives: dynamic regulation of bioactive lysophosphatidic acid and sphingosine-1-phosphate metabolism in the circulation.
Topics: Animals; Cardiovascular System; Humans; Lysophospholipids; Mice; Models, Animal; Receptors, Lysosphingolipid; Signal Transduction; Sphingosine; Time Factors | 2009 |
Regulation of lysophosphatidate signaling by autotaxin and lipid phosphate phosphatases with respect to tumor progression, angiogenesis, metastasis and chemo-resistance.
Topics: Animals; Disease Progression; Drug Resistance, Neoplasm; Female; Humans; Intercellular Signaling Peptides and Proteins; Lysophospholipids; Male; Mice; Multienzyme Complexes; Neoplasm Metastasis; Neoplasms; Neovascularization, Pathologic; Phosphatidate Phosphatase; Phosphodiesterase I; Phospholipase D; Phosphoric Diester Hydrolases; Pyrophosphatases; Signal Transduction; Sphingosine | 2011 |
Pharmacological tools for lysophospholipid GPCRs: development of agonists and antagonists for LPA and S1P receptors.
Topics: Animals; Drug Discovery; Humans; Lysophospholipids; Receptors, Lysophospholipid; Sphingosine | 2010 |
A role for lysophosphatidic acid and sphingosine 1-phosphate in the pathogenesis of systemic sclerosis.
Topics: Autoimmunity; Blood Vessels; Fibrosis; Humans; Lysophospholipids; Scleroderma, Systemic; Sphingosine | 2010 |
It's a lipid's world: bioactive lipid metabolism and signaling in neural stem cell differentiation.
Topics: Animals; Cell Differentiation; Ceramides; Energy Metabolism; Gangliosides; Globosides; Humans; Lipids; Lysophospholipids; MAP Kinase Signaling System; Membrane Microdomains; Neural Stem Cells; Phosphatidylinositols; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, sigma; Signal Transduction; Sphingosine | 2012 |
Role of sphingosine 1-phosphate and lysophosphatidic acid in fibrosis.
Topics: Animals; Fibrosis; Humans; Lysophospholipids; Models, Biological; Organ Specificity; Receptors, Lysosphingolipid; Sphingosine | 2013 |
Role of the lysophospholipid mediators lysophosphatidic acid and sphingosine 1-phosphate in lung fibrosis.
Topics: Capillary Permeability; Cell Physiological Phenomena; Epithelial Cells; Fibroblasts; Humans; Lysophospholipids; Pulmonary Alveoli; Pulmonary Fibrosis; Receptors, Lysophosphatidic Acid; Receptors, Lysosphingolipid; Signal Transduction; Sphingosine; Wound Healing | 2012 |
New insights into the role of sphingosine 1-phosphate and lysophosphatidic acid in the regulation of skeletal muscle cell biology.
Topics: Animals; Humans; Lysophospholipids; Mesenchymal Stem Cells; Muscle Cells; Muscle, Skeletal; Myoblasts; Sphingosine | 2013 |
Phospholipids: "greasing the wheels" of humoral immunity.
Topics: Animals; B-Lymphocytes; Cell Differentiation; Cell Membrane; Cell Proliferation; Chemotaxis; Humans; Immunity, Humoral; Lymphocyte Activation; Lysophospholipids; Mice; Signal Transduction; Sphingosine; T-Lymphocytes | 2013 |
The role of sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA) in regulation of osteoclastic and osteoblastic cells.
Topics: Animals; Bone Remodeling; Cell Communication; Humans; Lysophospholipids; Osteoblasts; Osteoclasts; Receptors, Lysosphingolipid; Sphingosine | 2013 |
Arguing the case for the autotaxin-lysophosphatidic acid-lipid phosphate phosphatase 3-signaling nexus in the development and complications of atherosclerosis.
Topics: Adipose Tissue; Animals; Apolipoproteins E; Atherosclerosis; Coronary Artery Disease; Genetic Predisposition to Disease; Humans; Lysophospholipids; Mice; Mice, Knockout; Phosphatidate Phosphatase; Phosphoric Diester Hydrolases; Plaque, Atherosclerotic; Risk; Sphingosine | 2014 |
Emerging roles for lysophospholipid mediators in pregnancy.
Topics: Endometrium; Female; Humans; Lysophospholipids; Maternal-Fetal Exchange; Neovascularization, Physiologic; Obstetric Labor, Premature; Ovary; Parturition; Placenta; Pre-Eclampsia; Pregnancy; Prostaglandins; Signal Transduction; Sphingosine | 2014 |
Lysophospholipid receptors in drug discovery.
Topics: Animals; Drug Discovery; Humans; Lysophospholipids; Molecular Targeted Therapy; Multiple Sclerosis; Receptors, Lysophosphatidic Acid; Receptors, Lysosphingolipid; Signal Transduction; Sphingosine | 2015 |
Lysophosphatidic Acid and Sphingosine-1-Phosphate: A Concise Review of Biological Function and Applications for Tissue Engineering.
Topics: Animals; Cell Differentiation; Cell Movement; Humans; Lysophospholipids; Receptors, G-Protein-Coupled; Sphingosine; Stem Cells; Tissue Engineering | 2015 |
Lysophospholipids in coronary artery and chronic ischemic heart disease.
Topics: Animals; Atherosclerosis; Coronary Artery Disease; Humans; Lysophospholipids; Myocardial Ischemia; Signal Transduction; Sphingosine | 2015 |
The importance of blood platelet lipid signaling in thrombosis and in sepsis.
Topics: Animals; Blood Platelets; Humans; Inflammation; Lipid Metabolism; Lysophospholipids; Phosphatidylinositol 3-Kinases; Signal Transduction; Sphingosine; Thrombosis; Type C Phospholipases | 2018 |
Bioactive lysolipids in cancer and angiogenesis.
Topics: Animals; Cell Movement; Humans; Lysophospholipids; Neoplasms; Neovascularization, Pathologic; Sphingosine | 2019 |
Roles of lysophosphatidic acid and sphingosine-1-phosphate in stem cell biology.
Topics: Animals; Cell Differentiation; Cell Proliferation; Homeostasis; Humans; Lysophospholipids; Models, Biological; Signal Transduction; Sphingosine; Stem Cells | 2018 |
Lipid Phosphate Phosphatases and Cancer.
Topics: Animals; Cell Membrane; Humans; Lysophospholipids; Neoplasms; Phosphatidate Phosphatase; Signal Transduction; Sphingosine; Up-Regulation | 2020 |
Lysolipids in Vascular Development, Biology, and Disease.
Topics: Animals; Cardiovascular Diseases; Cardiovascular System; Endothelial Cells; Humans; Ligands; Lysophospholipids; Morphogenesis; Receptors, Lysophosphatidic Acid; Receptors, Lysophospholipid; Sphingosine; Sphingosine-1-Phosphate Receptors; Wnt Signaling Pathway | 2021 |
The Many Roles of Lysophospholipid Mediators and Japanese Contributions to This Field.
Topics: Carrier Proteins; Japan; Lysophospholipids; Receptors, G-Protein-Coupled; Sphingosine | 2022 |
Lysophospholipids and their producing enzymes: Their pathological roles and potential as pathological biomarkers.
Topics: Biomarkers; Humans; Lysophospholipids; Receptors, G-Protein-Coupled; Sphingosine | 2023 |
99 other study(ies) available for lysophosphatidic acid and sphingosine
| Article | Year |
|---|---|
Sphingosine 1-phosphate stimulates rho-mediated tyrosine phosphorylation of focal adhesion kinase and paxillin in Swiss 3T3 fibroblasts.
Topics: 3T3 Cells; Actin Cytoskeleton; Actins; ADP Ribose Transferases; Animals; Botulinum Toxins; Cell Adhesion Molecules; Cell Division; Cytoskeletal Proteins; DNA Replication; Enzyme Activation; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; GTP-Binding Proteins; Lysophospholipids; Mice; Paxillin; Phosphoproteins; Phosphorylation; Protein Kinase C; Protein Processing, Post-Translational; Protein-Tyrosine Kinases; Recombinant Proteins; rho GTP-Binding Proteins; Second Messenger Systems; Sphingosine; Stimulation, Chemical; Suramin; Tetradecanoylphorbol Acetate | 1997 |
Membrane type 1-matrix metalloproteinase (MT1-MMP) cooperates with sphingosine 1-phosphate to induce endothelial cell migration and morphogenic differentiation.
Topics: Animals; Cattle; Cell Differentiation; Cell Movement; Cells, Cultured; Endothelium, Vascular; Humans; Lysophospholipids; Matrix Metalloproteinases, Membrane-Associated; Metalloendopeptidases; Neovascularization, Physiologic; Oligodeoxyribonucleotides, Antisense; Receptors, G-Protein-Coupled; Receptors, Lysophospholipid; Sphingosine; Vascular Endothelial Growth Factor A | 2004 |
The critical micelle concentrations of lysophosphatidic acid and sphingosylphosphorylcholine.
Topics: Lysophospholipids; Micelles; Molecular Structure; Phosphorylcholine; Sodium Chloride; Sphingosine; Water | 2004 |
S1P and LPA trigger Schwann cell actin changes and migration.
Topics: Actins; Animals; Animals, Newborn; Cell Movement; Cells, Cultured; Culture Media, Conditioned; Cytoskeleton; Enzyme Activation; Enzyme Inhibitors; Immunohistochemistry; Lysophospholipids; rac1 GTP-Binding Protein; Rats; rhoA GTP-Binding Protein; Schwann Cells; Sphingosine | 2004 |
Role of lysophospholipid growth factors in the modulation of aqueous humor outflow facility.
Topics: Actins; Animals; Aqueous Humor; Blotting, Western; Calcium; Cell Culture Techniques; Enzyme Inhibitors; Focal Adhesions; Gene Amplification; Humans; Lysophospholipids; Microscopy, Fluorescence; Myosin Light Chains; Phosphorylation; Receptors, G-Protein-Coupled; Receptors, Lysophospholipid; Reverse Transcriptase Polymerase Chain Reaction; rho GTP-Binding Proteins; Spectrometry, Fluorescence; Sphingosine; Swine; Trabecular Meshwork | 2004 |
Induction of connective tissue growth factor (CTGF) in human endothelial cells by lysophosphatidic acid, sphingosine-1-phosphate, and platelets.
Topics: Blood Platelets; Cell Culture Techniques; Cell Line; Connective Tissue Growth Factor; Endothelial Cells; Humans; Immediate-Early Proteins; Intercellular Signaling Peptides and Proteins; Lysophospholipids; RNA, Messenger; Signal Transduction; Sphingosine; Umbilical Veins | 2004 |
Serum bioactive lysophospholipids prevent TRAIL-induced apoptosis via PI3K/Akt-dependent cFLIP expression and Bad phosphorylation.
Topics: Adult; Animals; Apoptosis; Apoptosis Regulatory Proteins; bcl-Associated Death Protein; Carrier Proteins; CASP8 and FADD-Like Apoptosis Regulating Protein; Caspases; Cattle; Cell Line, Tumor; Clone Cells; Down-Regulation; Drug Resistance, Neoplasm; Female; Humans; Intracellular Signaling Peptides and Proteins; Lysophospholipids; Male; Membrane Glycoproteins; Middle Aged; Ovarian Neoplasms; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Serine-Threonine Kinases; Protein Transport; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Signal Transduction; Sphingosine; TNF-Related Apoptosis-Inducing Ligand; Tumor Necrosis Factor-alpha; Up-Regulation | 2004 |
A single amino acid determines preference between phospholipids and reveals length restriction for activation of the S1P4 receptor.
Topics: Amino Acid Substitution; Animals; CHO Cells; Cricetinae; Cricetulus; Glutamic Acid; Humans; Ligands; Lysophospholipids; Models, Molecular; Mutagenesis, Site-Directed; Pertussis Toxin; Protein Conformation; Protein Structure, Tertiary; Receptors, Lysosphingolipid; Recombinant Fusion Proteins; Sphingosine; Structure-Activity Relationship; Substrate Specificity | 2004 |
Extracellular matrix molecules regulate endothelial cell migration stimulated by lysophosphatidic acid.
Topics: Animals; Cattle; Cell Adhesion; Cell Movement; Cells, Cultured; Cytoskeletal Proteins; Disintegrins; DNA-Binding Proteins; Endothelium, Vascular; Extracellular Matrix Proteins; Fibronectins; Gelatin; Intracellular Signaling Peptides and Proteins; LIM Domain Proteins; Lysophospholipids; Microscopy, Video; Oligopeptides; Paxillin; Phosphoproteins; Sphingosine | 2004 |
Glycogen synthase kinase 3beta is a negative regulator of growth factor-induced activation of the c-Jun N-terminal kinase.
Topics: 3T3 Cells; Animals; Apoptosis; Blotting, Western; Cells, Cultured; Cytoplasm; DNA Mutational Analysis; Dose-Response Relationship, Drug; Enzyme Activation; Epidermal Growth Factor; Fibroblasts; Genetic Vectors; Glycogen Synthase Kinase 3; Glycogen Synthase Kinase 3 beta; Growth Substances; Homozygote; JNK Mitogen-Activated Protein Kinases; Ligands; Lithium Chloride; Lysophospholipids; Mice; Mitogen-Activated Protein Kinase 3; Mutation; Phosphorylation; Propidium; Protein Structure, Tertiary; Retroviridae; Signal Transduction; Sphingosine; Thymidine; Time Factors; Ultraviolet Rays | 2004 |
Lysophospholipids transactivate HER2/neu (erbB-2) in human gastric cancer cells.
Topics: Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; ErbB Receptors; Genes, erbB-2; Humans; Lysophospholipids; Metalloendopeptidases; Phosphorylation; Protein-Tyrosine Kinases; Receptor, ErbB-2; Sphingosine; Stomach Neoplasms; Transcriptional Activation; Tumor Cells, Cultured | 2005 |
Chloride channel activity in human lung fibroblasts and myofibroblasts.
Topics: 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Actins; Adenosine Triphosphate; Cell Differentiation; Cells, Cultured; Chloride Channels; Electrophysiology; Fetus; Fibroblasts; Humans; Lung; Lysophospholipids; Muscle, Smooth; Nitrobenzoates; Receptors, Lysophosphatidic Acid; Sphingosine; Transforming Growth Factor beta | 2005 |
Sphingosine-1-phosphate induces early response gene expression in C6 glioma cells.
Topics: Animals; Blotting, Northern; Cell Line, Tumor; Dose-Response Relationship, Drug; Drug Interactions; Estrenes; Gene Expression; Genes, fos; Glioma; Lysophospholipids; Mice; Pertussis Toxin; Phosphodiesterase Inhibitors; Pyrrolidinones; Receptors, Lysophosphatidic Acid; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sphingosine; Time Factors | 2005 |
Differential effects of lysolipids on steroid synthesis in cells expressing endogenous LPA2 receptor.
Topics: Animals; Base Sequence; Cattle; Cells, Cultured; Cholesterol; Corpus Luteum; DNA Primers; Female; Lysophospholipids; Progesterone; Receptors, Lysophosphatidic Acid; Sphingosine | 2005 |
Overlapping signaling pathways of sphingosine 1-phosphate and TGF-beta in the murine Langerhans cell line XS52.
Topics: Animals; Cell Differentiation; Cell Line; Chemotactic Factors; Chemotaxis; DNA-Binding Proteins; Langerhans Cells; Lysophospholipids; Mice; Receptors, Lysosphingolipid; Receptors, Transforming Growth Factor beta; RNA, Messenger; Signal Transduction; Smad Proteins; Smad3 Protein; Sphingosine; Trans-Activators; Transforming Growth Factor beta | 2005 |
Inhibition of autotaxin by lysophosphatidic acid and sphingosine 1-phosphate.
Topics: Allosteric Site; Binding Sites; Biosensing Techniques; Blotting, Western; Catalysis; Catalytic Domain; Cell Line; Cell Movement; DNA, Complementary; Dose-Response Relationship, Drug; Fluorescence Resonance Energy Transfer; Glucose-6-Phosphate Isomerase; Glycoproteins; Humans; Hydrolysis; Kinetics; Ligands; Lipid Metabolism; Lipids; Lysophosphatidylcholines; Lysophospholipids; Models, Chemical; Multienzyme Complexes; Mutagenesis; Neoplasm Metastasis; Neoplasms; Neovascularization, Pathologic; Phosphodiesterase I; Phospholipase D; Phosphoric Diester Hydrolases; Pyrophosphatases; Recombinant Fusion Proteins; Recombinant Proteins; Sphingosine; Transfection | 2005 |
Lysophospholipids enhance matrix metalloproteinase-2 expression in human endothelial cells.
Topics: Cell Line; Endothelium, Vascular; Gene Expression Regulation, Enzymologic; Humans; Lysophospholipids; Matrix Metalloproteinase 2; RNA, Messenger; Sphingosine | 2005 |
LPA and S1P increase corneal epithelial and endothelial cell transcellular resistance.
Topics: Actins; Animals; Cell Culture Techniques; Diphosphates; Electric Impedance; Endothelium, Corneal; Epithelium, Corneal; Fluorescent Antibody Technique, Indirect; Glycerol; GTP-Binding Protein alpha Subunits, Gi-Go; Lysophospholipids; Pertussis Toxin; Rabbits; Receptors, Lysophosphatidic Acid; Sphingosine; Tetradecanoylphorbol Acetate | 2005 |
Sphingosylphosphorylcholine-induced vasoconstriction of pulmonary artery: activation of non-store-operated Ca2+ entry.
Topics: Amides; Animals; Blotting, Western; Calcium; Calcium Channel Blockers; Calcium Signaling; Dose-Response Relationship, Drug; G-Protein-Coupled Receptor Kinase 1; In Vitro Techniques; Lanthanum; Lysophospholipids; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Phosphorylcholine; Pulmonary Artery; Pyridines; Rats; Sphingosine; Thapsigargin; Type C Phospholipases; Vasoconstriction | 2005 |
Regulation of cell survival by lipid phosphate phosphatases involves the modulation of intracellular phosphatidic acid and sphingosine 1-phosphate pools.
Topics: Animals; Apoptosis; Caspase 3; Caspase 7; Caspases; Cell Line; Cell Survival; CHO Cells; Cricetinae; Cricetulus; Enzyme Activation; Humans; Lysophospholipids; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Phosphatidate Phosphatase; Phosphatidic Acids; Sphingosine | 2005 |
Role of p38 mitogen-activated kinase and c-Jun terminal kinase in migration response to lysophosphatidic acid and sphingosine-1-phosphate in glioma cells.
Topics: Animals; Cell Line, Tumor; Cell Movement; Glioma; JNK Mitogen-Activated Protein Kinases; Lysophospholipids; p38 Mitogen-Activated Protein Kinases; Pertussis Toxin; Rats; Sphingosine | 2005 |
Neutrophil sphingosine 1-phosphate and lysophosphatidic acid receptors in pneumonia.
Topics: Adult; Aged; Aged, 80 and over; Case-Control Studies; Chemotaxis; Dimerization; Female; Gene Expression; Humans; Lysophospholipids; Male; Middle Aged; Neutrophils; Pneumonia; Protein Isoforms; Receptors, Interleukin-8A; Receptors, Lysophosphatidic Acid; Receptors, Lysophospholipid; Reference Values; Sphingosine | 2006 |
Lysophosphatidylserine stimulates L2071 mouse fibroblast chemotactic migration via a process involving pertussis toxin-sensitive trimeric G-proteins.
Topics: Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinases; Chemotaxis; Enzyme Activation; Estrenes; Extracellular Signal-Regulated MAP Kinases; Fibroblasts; Flavonoids; GTP-Binding Protein alpha Subunits, Gi-Go; Lysophospholipids; Mice; p38 Mitogen-Activated Protein Kinases; Pertussis Toxin; Phosphodiesterase Inhibitors; Phosphorylation; Proto-Oncogene Proteins c-akt; Pyrrolidinones; Receptors, Lysophosphatidic Acid; Sphingosine | 2006 |
Lysophospholipids elevate [Ca2+]i and trigger exocytosis in bovine chromaffin cells.
Topics: Animals; Base Sequence; Calcium; Calcium Channel Blockers; Calcium Signaling; Catecholamines; Cattle; Cell Membrane; Cell Separation; Cells, Cultured; Chromaffin Cells; Dose-Response Relationship, Drug; Electrophysiology; Enzyme Inhibitors; Exocytosis; Inositol 1,4,5-Trisphosphate; Lysophospholipids; Molecular Sequence Data; Reverse Transcriptase Polymerase Chain Reaction; Ryanodine; Sodium Channel Blockers; Sphingosine; Thapsigargin | 2006 |
The effect of hypoxia on lipid phosphate receptor and sphingosine kinase expression and mitogen-activated protein kinase signaling in human pulmonary smooth muscle cells.
Topics: Cell Hypoxia; Cells, Cultured; Gene Expression Regulation; Humans; Lung; Lysophospholipids; MAP Kinase Signaling System; Myocytes, Smooth Muscle; Phosphatidate Phosphatase; Phosphotransferases (Alcohol Group Acceptor); Receptors, Lysophosphatidic Acid; Receptors, Lysosphingolipid; Sphingosine | 2006 |
Lysophospholipids increase IL-8 and MCP-1 expressions in human umbilical cord vein endothelial cells through an IL-1-dependent mechanism.
Topics: Carrier Proteins; Chemokine CCL2; Chemotaxis; Endothelial Cells; Humans; Interleukin-1; Interleukin-8; Lysophospholipids; Pertussis Toxin; Proline; RNA, Messenger; Sphingosine; Thiocarbamates; Time Factors; Umbilical Veins; Up-Regulation; Vesicular Transport Proteins | 2006 |
Lysophospholipids control integrin-dependent adhesion in splenic B cells through G(i) and G(12)/G(13) family G-proteins but not through G(q)/G(11).
Topics: Animals; B-Lymphocytes; Cell Adhesion; GTP-Binding Protein alpha Subunits, G12-G13; GTP-Binding Protein alpha Subunits, Gq-G11; GTP-Binding Proteins; Integrins; Intercellular Adhesion Molecule-1; Intracellular Signaling Peptides and Proteins; Lysophospholipids; Mice; Mice, Inbred C57BL; Protein Serine-Threonine Kinases; rho GTP-Binding Proteins; rho-Associated Kinases; Sphingosine; Spleen | 2006 |
Tumor cell invasion of collagen matrices requires coordinate lipid agonist-induced G-protein and membrane-type matrix metalloproteinase-1-dependent signaling.
Topics: cdc42 GTP-Binding Protein; Cell Movement; Collagen; Extracellular Matrix; GTP-Binding Proteins; Humans; Lipids; Lysophospholipids; Matrix Metalloproteinase 14; Matrix Metalloproteinases; Models, Biological; Neoplasm Invasiveness; Neoplasms; rac1 GTP-Binding Protein; Receptors, Lysophosphatidic Acid; Receptors, Lysosphingolipid; RNA, Small Interfering; Signal Transduction; Sphingosine; Time Factors; Tumor Cells, Cultured | 2006 |
Progesterone-induced sphingosine kinase-1 expression in the rat uterus during pregnancy and signaling consequences.
Topics: Animals; bcl-X Protein; Cell Line, Tumor; Cell Proliferation; Cyclin D1; Enzymes; Female; Genes, Dominant; Humans; Immunologic Techniques; Leiomyoma; Lysophospholipids; Mutation; Myometrium; Myosin Light Chains; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Pregnancy; Pregnancy, Animal; Progesterone; Progestins; Rats; Rats, Sprague-Dawley; Receptors, Lysophospholipid; RNA, Messenger; Signal Transduction; Sphingosine; Uterus | 2007 |
Sphingosine-1-phosphate initiates rapid retraction of pseudopodia by localized RhoA activation.
Topics: Actins; Animals; Carrier Proteins; Cell Adhesion; Cell Line; Cell Movement; Cell Polarity; Enzyme Activation; Formins; Humans; Intracellular Signaling Peptides and Proteins; Lysophospholipids; Mice; Microtubules; NIH 3T3 Cells; Protein Serine-Threonine Kinases; Protein Transport; Pseudopodia; rac GTP-Binding Proteins; rho-Associated Kinases; rhoA GTP-Binding Protein; Sphingosine; Vinculin | 2007 |
Sphingosine 1-phosphate regulates inflammation-related genes in human endothelial cells through S1P1 and S1P3.
Topics: Cell Adhesion; Cells, Cultured; Chemotaxis; Endothelial Cells; Gene Expression Regulation; Humans; Inflammation Mediators; Intercellular Adhesion Molecule-1; Lysophospholipids; Receptors, Lysosphingolipid; RNA, Messenger; RNA, Small Interfering; Sphingosine | 2007 |
S1P-receptors in PC12 and transfected HEK293 cells: molecular targets of hypotensive imidazoline I(1) receptor ligands.
Topics: Animals; Antihypertensive Agents; Binding, Competitive; Calcium Signaling; Clonidine; Down-Regulation; Humans; Hypotension; Imidazoles; Imidazoline Receptors; Ligands; Lysophospholipids; Neurons; PC12 Cells; Protein Isoforms; Radioligand Assay; Rats; Receptor Aggregation; Receptors, Lysosphingolipid; RNA Interference; Sphingosine; Transfection | 2007 |
Production of nerve growth factor enhanced in cultured mouse astrocytes by glycerophospholipids, sphingolipids, and their related compounds.
Topics: Animals; Animals, Newborn; Astrocytes; Cells, Cultured; Glycerophospholipids; Lysophospholipids; Mice; Mice, Inbred ICR; Models, Biological; Nerve Growth Factor; Sphingolipids; Sphingosine | 2007 |
Lysophospholipids regulate excitability and exocytosis in cultured bovine chromaffin cells.
Topics: Action Potentials; Adrenal Medulla; Animals; Cattle; Cell Membrane; Cells, Cultured; Chromaffin Cells; Dose-Response Relationship, Drug; Electric Stimulation; Endocytosis; Exocytosis; Immunologic Factors; Lysophospholipids; Membrane Potentials; Neurosecretory Systems; Patch-Clamp Techniques; Potassium Channels; Receptors, G-Protein-Coupled; Sodium Channels; Sphingosine; Suramin | 2007 |
S1P and LPA have an attachment-dependent regulatory effect on invasion of epithelial ovarian cancer cells.
Topics: Actins; Biocompatible Materials; Blotting, Western; Cadherins; Carcinoma; Cell Adhesion; Cell Line, Tumor; Collagen; Drug Combinations; Extracellular Matrix; Female; Fluorescent Antibody Technique; Focal Adhesion Kinase 1; Humans; Laminin; Lysophospholipids; Neoplasm Invasiveness; Ovarian Neoplasms; Proteoglycans; Sphingosine | 2007 |
Involvement of Fyn tyrosine kinase in actin stress fiber formation in fibroblasts.
Topics: Actins; Animals; Fibroblasts; Humans; Lysophospholipids; Mice; NIH 3T3 Cells; Phosphorylcholine; Proto-Oncogene Proteins c-fyn; Recombinant Proteins; rho-Associated Kinases; RNA, Small Interfering; Signal Transduction; Sphingosine; Stress Fibers; Transfection | 2007 |
S1P(2) receptors mediate inhibition of glioma cell migration through Rho signaling pathways independent of PTEN.
Topics: Cell Line, Tumor; Cell Movement; Glioma; GTP-Binding Protein alpha Subunits, G12-G13; Humans; Lysophospholipids; PTEN Phosphohydrolase; rac1 GTP-Binding Protein; Receptors, Lysosphingolipid; rhoA GTP-Binding Protein; Signal Transduction; Sphingosine | 2008 |
Lysophospholipid receptor-mediated calcium signaling in human keratinocytes.
Topics: Calcium; Calcium Signaling; Cell Movement; Chemotaxis; Green Fluorescent Proteins; Humans; Keratinocytes; Lysophospholipids; Models, Biological; Receptors, Lysophospholipid; Receptors, Lysosphingolipid; Sphingosine; Thapsigargin; Thiazolidines; Type C Phospholipases | 2008 |
Distinguishing fibroblast promigratory and procontractile growth factor environments in 3-D collagen matrices.
Topics: Cell Culture Techniques; Cell Movement; Collagen; Fibroblasts; Foreskin; Gene Silencing; Growth Substances; Humans; Lysophospholipids; Male; Platelet-Derived Growth Factor; Receptors, Lysosphingolipid; Reverse Transcriptase Polymerase Chain Reaction; Sphingosine; Wound Healing | 2008 |
Involvement of lysophosphatidic acid, sphingosine 1-phosphate and ceramide 1-phosphate in the metabolization of phosphatidic acid by lipid phosphate phosphatases in bovine rod outer segments.
Topics: Adaptation, Ocular; Animals; Blotting, Western; Buffers; Cattle; Cell Separation; Ceramides; Dark Adaptation; Electrophoresis, Polyacrylamide Gel; Hydrolysis; Lysophospholipids; Phosphatidate Phosphatase; Phosphatidic Acids; Reactive Oxygen Species; Rod Cell Outer Segment; Sphingosine | 2008 |
Subtype-specific residues involved in ligand activation of the endothelial differentiation gene family lysophosphatidic acid receptors.
Topics: Amino Acid Sequence; Amino Acids; Animals; Cell Differentiation; Cell Line, Tumor; Computational Biology; Conserved Sequence; Endothelial Cells; Flow Cytometry; Humans; Ligands; Lysophospholipids; Models, Biological; Models, Molecular; Mutagenesis, Site-Directed; Mutant Proteins; Point Mutation; Rats; Receptors, Lysophosphatidic Acid; Sphingosine | 2008 |
Anticancer activity of FTY720: phosphorylated FTY720 inhibits autotaxin, a metastasis-enhancing and angiogenic lysophospholipase D.
Topics: Animals; Antineoplastic Agents; Female; Humans; Lysophospholipids; Mice; Mice, Inbred C57BL; Multienzyme Complexes; Neoplasm Metastasis; Neovascularization, Pathologic; Organophosphates; Phosphodiesterase I; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pyrophosphatases; Sphingosine | 2008 |
Identification of the orphan GPCR, P2Y(10) receptor as the sphingosine-1-phosphate and lysophosphatidic acid receptor.
Topics: Amino Acid Sequence; Animals; Calcium; CHO Cells; Cricetinae; Cricetulus; Humans; Ligands; Lysophospholipids; Mice; Molecular Sequence Data; Phylogeny; Protein Conformation; Receptors, Lysophosphatidic Acid; Receptors, Lysosphingolipid; Receptors, Purinergic P2; Reverse Transcriptase Polymerase Chain Reaction; RNA, Small Interfering; Sequence Analysis, Protein; Sphingosine; Tissue Distribution | 2008 |
Lysophosphatidic acid (LPA) and angiogenesis.
Topics: Amino Acid Sequence; Angiogenesis Inhibitors; Animals; Chick Embryo; Drug Evaluation, Preclinical; Lysophospholipids; Molecular Sequence Data; Neovascularization, Physiologic; Organophosphates; Pyridines; Receptors, Lysophosphatidic Acid; Sequence Homology, Amino Acid; Sphingosine; Substrate Specificity; Vascular Endothelial Growth Factor A | 2008 |
S1P induced changes in epithelial ovarian cancer proteolysis, invasion, and attachment are mediated by Gi and Rac.
Topics: Antigens, CD; Cadherins; Cell Adhesion; Cell Line, Tumor; Female; GTP-Binding Protein alpha Subunits, Gi-Go; Humans; Lysophospholipids; Matrix Metalloproteinase 14; Matrix Metalloproteinase 2; Neoplasm Invasiveness; Ovarian Neoplasms; Pertussis Toxin; rac GTP-Binding Proteins; Sphingosine; Urokinase-Type Plasminogen Activator | 2008 |
S1P differentially regulates migration of human ovarian cancer and human ovarian surface epithelial cells.
Topics: Ascites; Cell Line, Tumor; Cell Movement; Cell Shape; Enzyme Activation; Epithelial Cells; Extracellular Signal-Regulated MAP Kinases; Female; Humans; Lysophospholipids; Mitogen-Activated Protein Kinase Kinases; Ovarian Neoplasms; Protein Kinase C; Receptors, Lysosphingolipid; Signal Transduction; Sphingosine; Stress Fibers | 2008 |
Cross-talk between LPA1 and epidermal growth factor receptors mediates up-regulation of sphingosine kinase 1 to promote gastric cancer cell motility and invasion.
Topics: Blotting, Western; Breast Neoplasms; Cell Movement; Cell Proliferation; Chemotaxis; Colonic Neoplasms; ErbB Receptors; Humans; Interleukin-6; Interleukin-8; Lysophospholipids; Neoplasm Invasiveness; Phosphotransferases (Alcohol Group Acceptor); Receptors, Lysophosphatidic Acid; Receptors, Lysosphingolipid; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sphingosine; Stomach Neoplasms; Transcriptional Activation; Tumor Cells, Cultured; Up-Regulation; Urokinase-Type Plasminogen Activator | 2008 |
Expression patterns of the lysophospholipid receptor genes during mouse early development.
Topics: Animals; Gene Expression Regulation, Developmental; Lysophospholipids; Mice; Organ Specificity; Organogenesis; Receptors, Lysophosphatidic Acid; Sphingosine | 2008 |
Lipid G protein-coupled receptor ligand identification using beta-arrestin PathHunter assay.
Topics: Animals; Arrestins; beta-Arrestins; Cannabinoids; CHO Cells; Cricetinae; Cricetulus; Humans; Lysophospholipids; Mice; Receptors, G-Protein-Coupled; Sphingosine | 2009 |
High-throughput analysis of sphingosine 1-phosphate, sphinganine 1-phosphate, and lysophosphatidic acid in plasma samples by liquid chromatography-tandem mass spectrometry.
Topics: Chromatography, Liquid; Humans; Lysophospholipids; Reproducibility of Results; Sphingosine; Tandem Mass Spectrometry | 2009 |
Elevated serum levels of arachidonoyl-lysophosphatidic acid and sphingosine 1-phosphate in systemic sclerosis.
Topics: Adult; Case-Control Studies; Female; Humans; Lysophospholipids; Middle Aged; Phosphoric Diester Hydrolases; Scleroderma, Systemic; Sphingosine; Young Adult | 2009 |
Signal transduction responses to lysophosphatidic acid and sphingosine 1-phosphate in human prostate cancer cells.
Topics: Cell Division; Cell Line, Tumor; Culture Media, Serum-Free; Enzyme Activation; Gene Expression Regulation, Neoplastic; Humans; Isomerism; Lysophospholipids; Male; Phosphorylation; Prostatic Neoplasms; Receptors, Lysophosphatidic Acid; Receptors, Lysosphingolipid; RNA, Messenger; Signal Transduction; Sphingosine; Sphingosine-1-Phosphate Receptors; Tyrosine | 2009 |
Age-related changes in the metabolization of phosphatidic acid in rat cerebral cortex synaptosomes.
Topics: Aging; Animals; Ceramides; Cerebral Cortex; Cyclohexanones; Diglycerides; Glycerol; Lipid Metabolism; Lipoprotein Lipase; Lysophospholipids; Male; Monoglycerides; Phosphatidate Phosphatase; Protease Inhibitors; Rats; Rats, Wistar; Sphingosine; Synaptosomes | 2009 |
Utilization of the Tango beta-arrestin recruitment technology for cell-based EDG receptor assay development and interrogation.
Topics: Arrestins; beta-Arrestins; Biological Assay; Cell Line; Humans; Lysophospholipids; Organophosphates; Receptors, Lysophospholipid; Receptors, Lysosphingolipid; Signal Transduction; Sphingosine | 2009 |
Promigratory and procontractile growth factor environments differentially regulate cell morphogenesis.
Topics: Actins; Amides; Cell Aggregation; Cell Culture Techniques; Cell Line, Transformed; Cell Movement; Cell Shape; Collagen; Enzyme Inhibitors; Fibroblasts; Heterocyclic Compounds, 4 or More Rings; Humans; Intercellular Signaling Peptides and Proteins; Lysophospholipids; Male; Myosin Type II; Oncogene Protein p21(ras); Platelet-Derived Growth Factor; Pyridines; rho-Associated Kinases; Serum; Sphingosine; Vinculin | 2010 |
Lysophospholipids enhance taurine release from rat retinal vascular endothelial cells under hypoosmotic stress.
Topics: Animals; Cells, Cultured; Dose-Response Relationship, Drug; Endothelial Cells; Endothelium, Vascular; Gene Expression; Lysophospholipids; Male; Osmotic Pressure; Rats; Rats, Wistar; Receptors, Lysophosphatidic Acid; Receptors, Lysosphingolipid; Retinal Vessels; RNA, Messenger; Sphingosine; Taurine | 2009 |
Role of Rap1B and tumor suppressor PTEN in the negative regulation of lysophosphatidic acid--induced migration by isoproterenol in glioma cells.
Topics: Cell Movement; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Activation; Glioma; Humans; Isoproterenol; Lysophospholipids; Phosphorylation; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase; rac1 GTP-Binding Protein; rap GTP-Binding Proteins; Sphingosine | 2009 |
Natural lysophospholipids reduce Mycobacterium tuberculosis-induced cytotoxicity and induce anti-mycobacterial activity by a phagolysosome maturation-dependent mechanism in A549 type II alveolar epithelial cells.
Topics: Apoptosis; Cell Line; Cytoprotection; Disease Transmission, Infectious; Epithelial Cells; Host-Pathogen Interactions; Humans; Lysophospholipids; Macrophages, Alveolar; Mycobacterium tuberculosis; Phagosomes; Phospholipase D; Pulmonary Alveoli; Sphingosine; Tuberculosis | 2010 |
Ca2+ signaling induced by sphingosine 1-phosphate and lysophosphatidic acid in mouse B cells.
Topics: Animals; B-Lymphocytes; Bone Marrow; Calcium Signaling; Calcium-Transporting ATPases; Cell Culture Techniques; Cell Line; Lipid Metabolism; Lymphocyte Activation; Lymphopoiesis; Lysophospholipids; Mice; Precursor Cells, B-Lymphoid; Sphingosine; Spleen; Thapsigargin; Type C Phospholipases | 2010 |
Bioactive lipids lysophosphatidic acid and sphingosine 1-phosphate mediate breast cancer cell biological functions through distinct mechanisms.
Topics: Bone Marrow Cells; Breast Neoplasms; Cell Adhesion; Cell Movement; Cell Proliferation; Cells, Cultured; Chemokine CCL2; Chemokine CXCL1; Endothelium, Vascular; Enzyme-Linked Immunosorbent Assay; Extracellular Signal-Regulated MAP Kinases; Female; Granulocyte-Macrophage Colony-Stimulating Factor; Humans; Interleukin-6; Interleukin-8; Lysophospholipids; Neovascularization, Physiologic; Osteoclasts; Phosphatidylinositol 3-Kinases; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sphingosine; Umbilical Veins; Vascular Endothelial Growth Factor A | 2009 |
Neural tube defects and impaired neural progenitor cell proliferation in Gbeta1-deficient mice.
Topics: Animals; Brain; Cell Proliferation; Down-Regulation; Embryo, Mammalian; Endothelin-1; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation, Developmental; GTP-Binding Protein beta Subunits; Heterotrimeric GTP-Binding Proteins; Lysophospholipids; Mice; Mice, Knockout; Mutagenesis, Insertional; Neural Tube Defects; Neurogenesis; Neurons; Phosphorylation; Sphingosine; Stem Cells | 2010 |
A clean-up technology for the simultaneous determination of lysophosphatidic acid and sphingosine-1-phosphate by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry using a phosphate-capture molecule, Phos-tag.
Topics: Animals; Brain Chemistry; Cattle; Chemical Fractionation; Chloroform; Hydrogen-Ion Concentration; Lung; Lysophospholipids; Pyridines; Rats; Sensitivity and Specificity; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Sphingosine | 2010 |
Expression of sphingosine-1-phosphate receptors and lysophosphatidic acid receptors on cultured and xenografted human colon, breast, melanoma, and lung tumor cells.
Topics: Animals; Breast Neoplasms; Colonic Neoplasms; Endothelium, Vascular; Female; Humans; Immunoenzyme Techniques; Lung Neoplasms; Lysophospholipids; Melanoma; Mice; Mice, SCID; Neoplasm Transplantation; Receptors, Lysophosphatidic Acid; Receptors, Lysosphingolipid; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sphingosine; Transplantation, Heterologous; Tumor Cells, Cultured; Umbilical Cord | 2010 |
Diversity of lysophosphatidic acid receptor-mediated intracellular calcium signaling in early cortical neurogenesis.
Topics: Animals; Cadmium Chloride; Calcium; Calcium Signaling; Cells, Cultured; Cerebral Cortex; Dose-Response Relationship, Drug; Embryo, Mammalian; Extracellular Fluid; Female; Gene Expression Regulation, Developmental; Glutamic Acid; Intracellular Signaling Peptides and Proteins; Isoxazoles; Lysophospholipids; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Nerve Tissue Proteins; Neurogenesis; Neurons; Nickel; Organophosphates; Pertussis Toxin; Pituitary Adenylate Cyclase-Activating Polypeptide; Pregnancy; Propionates; Pyridines; RNA, Messenger; Sphingosine; Thapsigargin | 2010 |
[Lysophospholipids].
Topics: Female; Humans; Lysophospholipids; Male; Pregnancy; Sphingosine | 2010 |
Mechanism of sphingosine 1-phosphate- and lysophosphatidic acid-induced up-regulation of adhesion molecules and eosinophil chemoattractant in nerve cells.
Topics: Cell Line; Chemotactic Factors, Eosinophil; Humans; Lysophospholipids; Neurons; Receptors, Lysosphingolipid; Signal Transduction; Sphingosine; Up-Regulation | 2011 |
Lysophosphatidic acid enhances antimycobacterial response during in vivo primary Mycobacterium tuberculosis infection.
Topics: Acute Disease; Animals; Colony Count, Microbial; Female; Lung; Lysophospholipids; Mice; Mice, Inbred BALB C; Mycobacterium tuberculosis; Sphingosine; Time Factors; Treatment Outcome; Tuberculosis, Pulmonary | 2011 |
Kinetic analysis of autotaxin reveals substrate-specific catalytic pathways and a mechanism for lysophosphatidic acid distribution.
Topics: Amino Acid Substitution; Catalysis; Enzyme Inhibitors; Hydrolysis; Kinetics; Lysophospholipids; Multienzyme Complexes; Multiple Sclerosis; Mutation, Missense; Organophosphates; Phosphodiesterase I; Phosphoric Diester Hydrolases; Pyrophosphatases; Sphingosine; Substrate Specificity | 2011 |
Sphingosylphosphorylcholine induces stress fiber formation via activation of Fyn-RhoA-ROCK signaling pathway in fibroblasts.
Topics: ADP Ribose Transferases; Amino Acid Substitution; Animals; Botulinum Toxins; Enzyme Activation; Fibroblasts; Focal Adhesion Kinase 1; Focal Adhesions; Lysophospholipids; Mice; NIH 3T3 Cells; Phosphorylcholine; Proto-Oncogene Proteins c-fyn; Pseudopodia; Recombinant Proteins; rho GTP-Binding Proteins; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction; Sphingosine; Stress Fibers | 2012 |
Lysophosphatidic acid and sphingosine-1-phosphate promote morphogenesis and block invasion of prostate cancer cells in three-dimensional organotypic models.
Topics: Cell Culture Techniques; Cell Differentiation; Cell Line, Tumor; Cell Movement; Epithelium; GTP-Binding Proteins; Humans; Lysophospholipids; Male; Prostatic Neoplasms; RNA Interference; Signal Transduction; Sphingosine; Tumor Cells, Cultured | 2012 |
LPA is a chemorepellent for B16 melanoma cells: action through the cAMP-elevating LPA5 receptor.
Topics: alpha-MSH; Animals; Cell Membrane; Cell Polarity; Cell Proliferation; Chemotaxis; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Extracellular Signal-Regulated MAP Kinases; HeLa Cells; Humans; Lysophospholipids; Melanoma, Experimental; Mice; Phosphatidylinositol Phosphates; Phosphoric Diester Hydrolases; Polylysine; Receptors, Lysophosphatidic Acid; Serum; Sphingosine; Subcellular Fractions; Transfection | 2011 |
Epithelial cells utilize cortical actin/myosin to activate latent TGF-β through integrin α(v)β(6)-dependent physical force.
Topics: Actins; Antigens, Neoplasm; Cells, Cultured; Epithelial Cells; Humans; Integrins; Lysophospholipids; Myosins; Signal Transduction; Sphingosine; Transforming Growth Factor beta | 2012 |
Biosynthesis of alkyl lysophosphatidic acid by diacylglycerol kinases.
Topics: Cell Line, Tumor; Diacylglycerol Kinase; Enzyme Activation; HEK293 Cells; Humans; Lysophospholipids; Sphingosine | 2012 |
Regulation of the Hippo-YAP pathway by G-protein-coupled receptor signaling.
Topics: Acyltransferases; Animals; Cell Cycle Proteins; Cell Line; Cell Movement; Cell Proliferation; Humans; Lysophospholipids; Neoplasms; Nuclear Proteins; Organ Size; Phosphorylation; Protein Serine-Threonine Kinases; Receptors, G-Protein-Coupled; Serum; Signal Transduction; Sphingosine; Transcription Factors | 2012 |
Identification of serum-derived sphingosine-1-phosphate as a small molecule regulator of YAP.
Topics: Actins; Animals; Cell Cycle Proteins; Cell Nucleus; Cell Proliferation; Cell Transformation, Neoplastic; Embryonic Stem Cells; Gene Expression Regulation; HEK293 Cells; Humans; Lysophospholipids; Mice; Nuclear Proteins; Phosphorylation; Receptors, Lysosphingolipid; rho GTP-Binding Proteins; Signal Transduction; Sphingosine; Transcription Factors | 2012 |
Phospholipase C epsilon links G protein-coupled receptor activation to inflammatory astrocytic responses.
Topics: Animals; Astrocytes; Cyclooxygenase 2; Enzyme Activation; Inflammation; Lysophospholipids; Mice; Mice, Inbred C57BL; Mice, Knockout; Models, Biological; NF-kappa B; Phosphoinositide Phospholipase C; Protein Kinase C; Receptors, G-Protein-Coupled; Sphingosine; Thrombin; Wound Healing | 2013 |
Phosphatidic acid metabolism in rat liver cell nuclei.
Topics: Animals; Calcium; Cell Nucleus; Ceramides; Diglycerides; Immunoblotting; Lipid Metabolism; Lipoprotein Lipase; Liver; Lysophospholipids; Magnesium; Male; Microscopy, Electron; Monoacylglycerol Lipases; Monoglycerides; Octoxynol; Phosphatidate Phosphatase; Phosphatidic Acids; Phospholipases A; Rats; Rats, Wistar; Sphingosine | 2013 |
Overexpression of autotaxin, a lysophosphatidic acid-producing enzyme, enhances cardia bifida induced by hypo-sphingosine-1-phosphate signaling in zebrafish embryo.
Topics: Animals; Down-Regulation; Embryo, Nonmammalian; Heart Defects, Congenital; HEK293 Cells; Humans; Isoxazoles; Lysophospholipids; Phenotype; Phosphoric Diester Hydrolases; Propionates; Receptors, Lysophosphatidic Acid; RNA, Messenger; Signal Transduction; Sphingosine; Zebrafish | 2014 |
Potentials of the circulating pruritogenic mediator lysophosphatidic acid in development of allergic skin inflammation in mice: role of blood cell-associated lysophospholipase D activity of autotaxin.
Topics: Animals; Blood Cells; Cell Membrane; Chromatography, Liquid; Hypersensitivity; Inflammation; Lysophospholipids; Male; Mass Spectrometry; Mice; Mice, Inbred BALB C; Phosphoric Diester Hydrolases; Protein Binding; Pruritus; Skin; Solubility; Sphingosine | 2014 |
Lysophosphatidic acid and sphingosine 1-phosphate metabolic pathways and their receptors are differentially regulated during decidualization of human endometrial stromal cells.
Topics: Adult; Cell Differentiation; Cell Movement; Cell Proliferation; Decidua; Embryo Implantation; Endometrium; Estrogens; Female; Humans; Lysophospholipids; Middle Aged; Phosphatidate Phosphatase; Phosphoric Diester Hydrolases; Pregnancy; Progesterone; Receptors, Lysophosphatidic Acid; Receptors, Lysosphingolipid; RNA, Messenger; Sphingosine; Sphingosine-1-Phosphate Receptors; Stromal Cells; Transcriptional Activation; Up-Regulation | 2014 |
Lysophosphatidic acid stimulates cell migration of satellite cells. A role for the sphingosine kinase/sphingosine 1-phosphate axis.
Topics: Animals; Cell Movement; Cells, Cultured; Lysophospholipids; Male; Mice; Mice, Inbred C57BL; Phosphotransferases (Alcohol Group Acceptor); Satellite Cells, Skeletal Muscle; Signal Transduction; Sphingosine | 2014 |
G-protein-coupled receptor cell signaling pathways mediating embryonic chick retinal growth cone collapse induced by lysophosphatidic acid and sphingosine-1-phosphate.
Topics: Animals; Chickens; Growth Cones; Lysophospholipids; Receptors, G-Protein-Coupled; Retinal Neurons; Signal Transduction; Sphingosine | 2014 |
Expression of bioactive lysophospholipids and processing enzymes in the vitreous from patients with proliferative diabetic retinopathy.
Topics: Adult; Aged; Aged, 80 and over; Case-Control Studies; Diabetic Retinopathy; Female; Humans; Lysophospholipids; Male; Middle Aged; Phospholipases A1; Phospholipases A2; Phosphotransferases (Alcohol Group Acceptor); Receptors, Lysosphingolipid; Sphingosine; Sphingosine-1-Phosphate Receptors; Vitreous Body | 2014 |
Introduction to the ECR special issue on lysophospholipids in biology.
Topics: Animals; Cell Communication; Humans; Lysophospholipids; Sphingosine | 2015 |
Regulation of autotaxin expression and secretion by lysophosphatidate and sphingosine 1-phosphate.
Topics: Adipose Tissue; Animals; Carbolines; Gene Expression Regulation; Humans; Inflammation; Lysophospholipids; Mice; Phosphoric Diester Hydrolases; Receptors, G-Protein-Coupled; Sphingosine; Tumor Necrosis Factor-alpha; Wound Healing | 2015 |
Dyslipidemia regulates thrombospondin-1-induced vascular smooth muscle cell chemotaxis.
Topics: Cells, Cultured; Chemotaxis; Dyslipidemias; Humans; Lipoproteins, HDL; Lipoproteins, LDL; Lysophospholipids; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Receptors, Lysophosphatidic Acid; Receptors, Lysosphingolipid; RNA Interference; Signal Transduction; Sphingosine; Sphingosine-1-Phosphate Receptors; Thrombospondin 1; Time Factors; Transfection | 2015 |
Tetracyclines increase lipid phosphate phosphatase expression on plasma membranes and turnover of plasma lysophosphatidate.
Topics: Animals; Cell Line; Cell Membrane; Enzyme Stability; Extracellular Space; Female; Gene Expression Regulation, Enzymologic; Humans; Lysophospholipids; Mice; Phosphatidate Phosphatase; Rats; Sphingosine; Tetracyclines | 2016 |
Mildly oxidized HDL decrease agonist-induced platelet aggregation and release of pro-coagulant platelet extracellular vesicles.
Topics: Blood Platelets; Coagulants; Flow Cytometry; Homeostasis; Humans; Lipids; Lipoproteins, HDL; Lipoproteins, LDL; Lysophospholipids; Mass Spectrometry; Nanoparticles; Oxidation-Reduction; Oxygen; Platelet Aggregation; Sphingosine | 2017 |
Structural Insight into Substrate Selection and Catalysis of Lipid Phosphate Phosphatase PgpB in the Cell Membrane.
Topics: Catalysis; Catalytic Domain; Cell Membrane; Escherichia coli; Escherichia coli Proteins; Lysophospholipids; Phosphatidate Phosphatase; Sphingosine; Substrate Specificity | 2016 |
A novel approach for measuring sphingosine-1-phosphate and lysophosphatidic acid binding to carrier proteins using monoclonal antibodies and the Kinetic Exclusion Assay.
Topics: Antibodies, Monoclonal; Carrier Proteins; Fatty Acids, Nonesterified; Humans; Kinetics; Ligands; Lysophospholipids; Protein Binding; Receptors, Cell Surface; Serum Albumin; Signal Transduction; Sphingosine | 2016 |
Role of lipid phosphate phosphatase 3 in human aortic endothelial cell function.
Topics: Aorta; Apoptosis; Catalytic Domain; Cell Adhesion; Cell Movement; Cells, Cultured; Cytokines; Endothelial Cells; Humans; Inflammation Mediators; Lysophospholipids; Mutation; Neovascularization, Physiologic; Phosphatidate Phosphatase; Primary Cell Culture; Protein Domains; RNA Interference; Signal Transduction; Sphingosine; Substrate Specificity; Transfection; Vascular Endothelial Growth Factor A | 2016 |
Proliferation and differentiation of rat adipose‑derived stem cells are regulated by yes‑associated protein.
Topics: Actin Cytoskeleton; Adipogenesis; Adipose Tissue; Animals; Apoptosis Regulatory Proteins; Cell Count; Cell Differentiation; Cell Proliferation; Gene Expression Regulation; Lentivirus; Lysophospholipids; Male; Osteogenesis; Rats, Sprague-Dawley; RNA, Small Interfering; Sphingosine; Stem Cells; Subcellular Fractions; Transduction, Genetic; YAP-Signaling Proteins | 2018 |
A conjunctive lipidomic approach reveals plasma ethanolamine plasmalogens and fatty acids as early diagnostic biomarkers for colorectal cancer patients.
Topics: Aged; Ceramides; Cholesterol; Colorectal Neoplasms; Early Detection of Cancer; Female; Humans; Lipidomics; Lipoproteins, HDL; Lipoproteins, LDL; Lysophosphatidylcholines; Lysophospholipids; Male; Middle Aged; Plasmalogens; Sphingosine; Triglycerides | 2020 |
Therapeutic Targeting of the Secreted Lysophospholipase D Autotaxin Suppresses Tuberous Sclerosis Complex-Associated Tumorigenesis.
Topics: Angiomyolipoma; Animals; Apoptosis; Ataxin-1; Cell Movement; Cell Proliferation; Cell Transformation, Neoplastic; Female; Humans; Imidazoles; Kidney Neoplasms; Lysophospholipids; Mice; Mice, Inbred NOD; Mice, Knockout; Pyrimidines; Signal Transduction; Sphingosine; Tuberous Sclerosis; Tuberous Sclerosis Complex 2 Protein; Tumor Cells, Cultured | 2020 |
Lysophospholipids in Lung Inflammatory Diseases.
Topics: Lung; Lysophospholipids; Receptors, G-Protein-Coupled; Signal Transduction; Sphingosine | 2021 |
Modulation of Neurolipid Signaling and Specific Lipid Species in the Triple Transgenic Mouse Model of Alzheimer's Disease.
Topics: Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Brain; Disease Models, Animal; Fatty Acids, Unsaturated; Hippocampus; Humans; Lipids; Lysophospholipids; Male; Mice, Transgenic; Phospholipids; Presenilin-1; Signal Transduction; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Sphingosine; tau Proteins | 2021 |
Differential activation mechanisms of lipid GPCRs by lysophosphatidic acid and sphingosine 1-phosphate.
Topics: Animals; Azetidines; Benzyl Compounds; Cryoelectron Microscopy; GTP-Binding Protein alpha Subunits, Gi-Go; Humans; Lysophospholipids; Molecular Conformation; Molecular Docking Simulation; Multiple Sclerosis; Receptors, Lysophosphatidic Acid; Recombinant Proteins; Sf9 Cells; Single Molecule Imaging; Sphingosine; Sphingosine-1-Phosphate Receptors; Spodoptera | 2022 |
Lysophosphatidic Acid Promotes the Expansion of Cancer Stem Cells via TRPC3 Channels in Triple-Negative Breast Cancer.
Topics: Breast; Calcium; Cell Line, Tumor; Epithelial-Mesenchymal Transition; Female; Gene Expression Regulation, Neoplastic; Humans; Interleukin-8; Lysophospholipids; Neoplastic Stem Cells; Receptors, Lysophosphatidic Acid; Signal Transduction; Sphingosine; Triple Negative Breast Neoplasms; TRPC Cation Channels | 2022 |
Lysophosphatidic acid, ceramide 1-phosphate and sphingosine 1-phosphate in peripheral blood of patients with idiopathic pulmonary fibrosis.
Topics: Ceramides; Fibrosis; Humans; Idiopathic Pulmonary Fibrosis; Lysophospholipids; Sphingosine | 2022 |