Compounds > lysophosphatidic acid
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lysophosphatidic acid and lysophosphatidylcholines

lysophosphatidic acid has been researched along with lysophosphatidylcholines in 63 studies

Research

Studies (63)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's20 (31.75)29.6817
2010's35 (55.56)24.3611
2020's8 (12.70)2.80

Authors

AuthorsStudies
Abrahani, A; An, D; Chan, N; Ghosh, S; Pulinilkunnil, T; Qi, D; Rodrigues, B; Yip, P1
Bassa, BV; Ganji, SH; Kamanna, VS; Roh, DD1
Christodoulou, E; Goding, JW; Kikuchi, K; Moolenaar, WH; Nagano, T; Perrakis, A; Ruurs, P; Takakusa, H; van Meeteren, LA1
Aoki, J; Arai, H; Fujimaki, T; Hama, K; Kishi, Y; Kitayama, J; Okudaira, S; Shida, D; Tanaka, M; Yamori, T1
Aoki, J; Arai, H; Kobayashi, T; Moriya-Ito, K; Murakami-Murofushi, K; Okudaira, S; Shimamoto, C; Tanaka, M; Tsuda, S1
Siess, W1
Inaoka, Y; Yamazaki, M1
Huang, LS; Jeong, TS; Kim, MR; Sok, DE1
Ikeda, H; Kishimoto, T; Mizuno, K; Nakamura, K; Ohkawa, R; Ohshima, N; Okubo, S; Tozuka, M; Yatomi, Y; Yokota, H1
Kienesberger, PC; Kohlwein, SD; Lass, A; Preiss-Landl, K; Wolinski, H; Zechner, R; Zimmermann, R1
Boutin, JA; Chomarat, P; Cogé, F; Ferry, G; Fould, B; Galizzi, JP; Giganti, A; Moulharat, N; Rodriguez, M; Saulnier-Blache, JS; Valet, P1
Aoki, J; Chun, J; Inoue, M; Matsushita, Y; Ueda, H; Xie, W1
Aoki, J; Inoue, M; Ma, L; Ueda, H1
Brindley, DN; Gaetano, C; Goping, IS; Samadi, N1
Farrugia, G; Kendrick, ML; Kraichely, RE; Sarr, MG; Strege, PR1
Brindley, DN; Gaetano, CG; Lynch, KR; Macdonald, TL; Samadi, N; Tomsig, JL1
Kanzaki, H; Kume, T; Taira, S; Tokumura, A; Yasuda, K1
Baker, DL; Bridson, PK; North, EJ; Osborne, DA; Parrill, AL1
Xu, Y; Zhao, Z1
Aoki, J; Chun, J; Inoue, M; Ma, L; Nagai, J; Uchida, H; Ueda, H1
Maluccio, MA; Scott, RE; Skill, NJ; Wu, J1
Baker, DL; Best, MD; Bostic, HE; Hoeglund, AB; Howard, AL; Parrill, AL; Wanjala, IW1
Aoki, J; Inoue, M; Ma, L; Nagai, J; Uchida, H; Ueda, H1
Yatomi, Y1
Nagai, J; Ueda, H1
Abbott, AM; Baker, DL; Gacasan, SB; Mize, CD; Parrill, AL1
Aoki, J; Hama, K; Hashimoto, T; Igarashi, K; Okudaira, S; Yatomi, Y1
Fu, R; Li, ZW; Li, ZY; Zhao, C; Zhao, YR1
Albers, HM; Ovaa, H1
Adamski, J; Berg, K; Björkbacka, H; Edsfeldt, A; Gonçalves, I; Grufman, H; Ko, NY; Nilsson, J; Nilsson, M; Nitulescu, M; Persson, A; Prehn, C1
Aidinis, V; Kaffe, E; Mouratis, MA; Sevastou, I1
Aoki, J; Asano, Y; Igarashi, K; Ishii, S; Kadono, T; Nakamura, K; Ohkawa, R; Sato, S; Shimizu, T; Sumida, H; Tamaki, K; Yanagida, K; Yatomi, Y1
Creutz, CE; Eaton, JM; Gee, VE; Hira, JK1
Albers, HM; Aoki, J; Bai, Z; Cai, L; Hata, E; Hayasaka, H; Komai, Y; Kubo, A; Miyasaka, M; Okudaira, S; Ovaa, H; Suematsu, M; Sugiura, Y; Takeda, A; Tanaka, T; Tohya, K; Umemoto, E; Veeraveedu, PT1
Bornhäuser, M; Brenner, S; Brors, B; Ehninger, G; Heiderich, C; Hofmann, WK; Jacobi, A; Koch, S; Ortlepp, C; Ryser, M; Steudel, C; Thiede, C1
Matsuhashi, M; Nagura, Y; Nojiri, T; Ohkawa, R; Takahashi, K; Tokuhara, Y; Tsuno, NH; Yatomi, Y1
Ben Gharsa, H; Ben Lasfar, Z; Borchani, L; El Ayeb, M; Safra, I; Sassi, A; Shahbazzadeh, D1
Daida, H; Dohi, T; Kishimoto, T; Kojima, T; Kurano, M; Kurata, T; Miyauchi, K; Miyazaki, T; Nakamura, K; Nishino, A; Ogita, M; Ohkawa, R; Shimada, K; Tamura, H; Yaginuma, K; Yanagisawa, N; Yatomi, Y; Yokoyama, K1
Ajandouz, el H; Bouza, B; Fontbonne, H; Lombardo, D; Puigserver, A1
Ferguson, CG; Lee, WY; Madan, D; Prestwich, GD; Testa, CA1
Abdel-Latif, A; Morris, AJ; Ratajczak, MZ; Schneider, G; Sellers, ZP1
Anantharamaiah, GM; Chattopadhyay, A; Faull, KF; Fogelman, AM; Fogelman, SI; Grijalva, V; Hough, G; Hwang, LH; Meriwether, D; Navab, M; Reddy, ST; Su, F; Wagner, AC1
Exley, M; Lange, M; Nowak-Machen, M; Robson, SC; Usheva, A; Wu, S1
Ackerman, SJ; Berdyshev, E; Christman, JW; Natarajan, V; Nyenhuis, S; Park, GY1
Baker, DL; Joe, MJ; Norman, DD; Palanisamy, DJ; Parrill, AL; Ragle, LE; Stein, RS; Tigyi, G1
Bui, HH; Chambers, MG; Jones, SB; Lin, C; Mitchell, PG; Norman, BH; Oskins, JL; Pfeifer, LA; Swearingen, CA; Thirunavukkarasu, K1
Bascands, JL; Bertrand-Michel, J; Dupuy, A; Feigerlova, E; Gourdy, P; Guerci, B; Hadjadj, S; Halimi, JM; Roussel, R; Saulnier-Blache, JS; Schanstra, JP1
Annoot, D; Bienvenu, N; Bock, X; Brys, R; Cherel, L; Christophe, T; Conrath, K; David, C; Desroy, N; Fleury, D; Galien, R; Heckmann, B; Heiermann, J; Hengeveld, WJ; Housseman, C; Jans, M; Joncour, A; Labeguere, V; Le Tallec, S; Lepissier, L; Mollat, P; Monjardet, A; Peixoto, C; Pilzak, G; Roncoroni, V; Soror, S; Steyaert, J; Touitou, R; Triballeau, N; van der Aar, E; Vandervoort, N; Vercheval, L; Wakselman, E; Wohlkonig, A1
Aihara, M; Aoki, J; Honjo, M; Igarashi, K; Igarashi, N; Kano, K; Kurano, M; Weinreb, RN; Yatomi, Y1
Aoki, J; Daida, H; Dohi, T; Hosogaya, S; Igarashi, K; Ikeda, H; Kishimoto, T; Kurano, M; Miyauchi, K; Nojiri, T; Ohkawa, R; Okubo, S; Ozaki, Y; Sakai, N; Tozuka, M; Yatomi, Y1
Chen, GX; Yang, F1
Li, Y; Liang, B; Liao, S; Wang, J; Xiao, R; Yang, W; Zhang, L; Zhang, Z1
Chlubek, D; Dołęgowska, B; Heryć, R; Michalczyk, A; Safranow, K1
Cvrtila, A; Dragojević, S; Jelić, D; Kraljić, K; Mesić, M; Sinković, V; Žiher, D1
Aoki, J; Ikeda, H; Ito, N; Kano, K; Kurano, M; Saigusa, D; Saito, R; Sekiguchi, M; Sumitani, M; Uranbileg, B; Uruno, A; Yamada, Y; Yatomi, Y1
Fu, WW; Li, L; Li, WJ; Song, YH; Wu, RT; Wu, WY; Xie, MY; Yin, SH1
Chen, Y; Guo, J; Liu, T; Liu, Z; Meng, W; Peng, F; Peng, J; Rao, T; Tan, Z; Yu, J1
Fukui, M; Irahara, M; Iwasa, T; Kuwahara, A; Morito, K; Tanaka, T; Tokumura, A; Tsutsumi, T; Yamamoto-Mikami, A1
Aoki, J; Ito, N; Kano, K; Kurano, M; Sumitani, M; Uchida, K; Uranbileg, B; Yatomi, Y1
Neya, M; Okada, H; Tokumura, A; Tsutsumi, T; Yasuda, K1
Eymery, MC; Hausmann, J; McCarthy, AA1
Arciniega, M; Benítez-Angeles, M; García-Villegas, R; Gutiérrez Castañeda, ÓE; Hernández-Araiza, I; Islas, LD; Liedtke, WB; Llorente, I; Morales-Buenrostro, LE; Real, FH; Romero, AEL; Rosenbaum, T; Torres-Quiroz, F; Tovar-Y-Romo, LB; Vergara-Jaque, A1
Aoyama, M; Iwaki, S; Kannagi, R; Kyogashima, M; Shimizu, Y; Tamiya-Koizumi, K; Tokumura, A; Tsutsumi, T1

Reviews

8 review(s) available for lysophosphatidic acid and lysophosphatidylcholines

ArticleYear
Bioactive lysophospholipids and mesangial cell intracellular signaling pathways: role in the pathobiology of kidney disease.
    Histology and histopathology, 2005, Volume: 20, Issue:2

    Topics: Animals; Cell Proliferation; Glomerular Mesangium; Humans; Kidney Diseases; Lysophosphatidylcholines; Lysophospholipids; Models, Biological; Phosphorylcholine; Receptors, Lysophosphatidic Acid; Receptors, Lysophospholipid; Signal Transduction; Sphingosine

2005
Platelet interaction with bioactive lipids formed by mild oxidation of low-density lipoprotein.
    Pathophysiology of haemostasis and thrombosis, 2006, Volume: 35, Issue:3-4

    Topics: Blood Coagulation; Blood Platelets; Cholesterol, LDL; F2-Isoprostanes; Fibrinolysis; Humans; Lipids; Lysophosphatidylcholines; Lysophospholipids; Oxidation-Reduction; Phosphatidylcholines; Platelet Activation; Signal Transduction

2006
[Clinical introduction of lysophosphatidic acid and autotaxin assays].
    Rinsho byori. The Japanese journal of clinical pathology, 2010, Volume: 58, Issue:6

    Topics: Biomarkers; Chronic Disease; Humans; Liver Diseases; Lymphoma; Lysophosphatidylcholines; Lysophospholipids; Multienzyme Complexes; Phosphodiesterase I; Phosphoric Diester Hydrolases; Pyrophosphatases; Receptors, G-Protein-Coupled

2010
[Function and biological activities of the autotaxin-LPA axis].
    Sheng li xue bao : [Acta physiologica Sinica], 2011, Dec-25, Volume: 63, Issue:6

    Topics: Animals; Cell Movement; Cell Proliferation; Humans; Lysophosphatidylcholines; Lysophospholipids; Phospholipases; Phosphoric Diester Hydrolases; Receptors, G-Protein-Coupled

2011
Chemical evolution of autotaxin inhibitors.
    Chemical reviews, 2012, May-09, Volume: 112, Issue:5

    Topics: Alternative Splicing; Animals; Biological Assay; Cell Proliferation; Humans; Isoenzymes; Lysophosphatidylcholines; Lysophospholipids; Models, Molecular; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Signal Transduction

2012
Lysoglycerophospholipids in chronic inflammatory disorders: the PLA(2)/LPC and ATX/LPA axes.
    Biochimica et biophysica acta, 2013, Volume: 1831, Issue:1

    Topics: Animals; Chronic Disease; Humans; Inflammation; Lysophosphatidylcholines; Lysophospholipids; Phospholipases A2; Phosphoric Diester Hydrolases; Signal Transduction

2013
Polyunsaturated lysophosphatidic acid as a potential asthma biomarker.
    Biomarkers in medicine, 2016, Volume: 10, Issue:2

    Topics: Adult; Airway Remodeling; Allergens; Animals; Asthma; Biomarkers; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Humans; Inflammation; Lung; Lysophosphatidylcholines; Lysophospholipids; Mice; Phospholipases A1; Phosphoric Diester Hydrolases; Receptors, Lysophosphatidic Acid

2016
Production of extracellular lysophosphatidic acid in the regulation of adipocyte functions and liver fibrosis.
    World journal of gastroenterology, 2018, Sep-28, Volume: 24, Issue:36

    Topics: Adipocytes; Animals; Humans; Insulin Resistance; Liver Cirrhosis; Lysophosphatidylcholines; Lysophospholipids; Models, Animal; Obesity; Phosphoric Diester Hydrolases; Receptors, Lysophosphatidic Acid; Signal Transduction

2018

Other Studies

55 other study(ies) available for lysophosphatidic acid and lysophosphatidylcholines

ArticleYear
Palmitoyl lysophosphatidylcholine mediated mobilization of LPL to the coronary luminal surface requires PKC activation.
    Journal of molecular and cellular cardiology, 2004, Volume: 37, Issue:5

    Topics: Animals; Blood Glucose; Diazoxide; Endothelium, Vascular; Glucose; Heart; Heparin; In Vitro Techniques; Insulin; Lipoprotein Lipase; Lysophosphatidylcholines; Lysophospholipids; Male; Myocardium; Myocytes, Cardiac; Naphthalenes; Palmitic Acid; Perfusion; Phospholipase D; Protein Kinase C; Protein Transport; Rats; Rats, Wistar; Triglycerides

2004
Inhibition of autotaxin by lysophosphatidic acid and sphingosine 1-phosphate.
    The Journal of biological chemistry, 2005, Jun-03, Volume: 280, Issue:22

    Topics: Allosteric Site; Binding Sites; Biosensing Techniques; Blotting, Western; Catalysis; Catalytic Domain; Cell Line; Cell Movement; DNA, Complementary; Dose-Response Relationship, Drug; Fluorescence Resonance Energy Transfer; Glucose-6-Phosphate Isomerase; Glycoproteins; Humans; Hydrolysis; Kinetics; Ligands; Lipid Metabolism; Lipids; Lysophosphatidylcholines; Lysophospholipids; Models, Chemical; Multienzyme Complexes; Mutagenesis; Neoplasm Metastasis; Neoplasms; Neovascularization, Pathologic; Phosphodiesterase I; Phospholipase D; Phosphoric Diester Hydrolases; Pyrophosphatases; Recombinant Fusion Proteins; Recombinant Proteins; Sphingosine; Transfection

2005
Autotaxin is overexpressed in glioblastoma multiforme and contributes to cell motility of glioblastoma by converting lysophosphatidylcholine to lysophosphatidic acid.
    The Journal of biological chemistry, 2006, Jun-23, Volume: 281, Issue:25

    Topics: Blotting, Western; Brain; Cell Line, Tumor; Cell Movement; Electrophoresis, Polyacrylamide Gel; Gene Expression Regulation, Neoplastic; Glioblastoma; Humans; Lysophosphatidylcholines; Lysophospholipids; Models, Biological; Multienzyme Complexes; Phosphodiesterase I; Phosphoric Diester Hydrolases; Pyrophosphatases; Time Factors; Transfection

2006
Cyclic phosphatidic acid is produced by autotaxin in blood.
    The Journal of biological chemistry, 2006, Sep-08, Volume: 281, Issue:36

    Topics: Animals; Antibodies, Monoclonal; Blood; Cattle; Ether; Humans; Lysophosphatidylcholines; Lysophospholipids; Metals; Multienzyme Complexes; Peptide Fragments; Phosphodiesterase I; Phosphoric Diester Hydrolases; Pyrophosphatases; Rats; Recombinant Proteins; Sodium Chloride

2006
Vesicle fission of giant unilamellar vesicles of liquid-ordered-phase membranes induced by amphiphiles with a single long hydrocarbon chain.
    Langmuir : the ACS journal of surfaces and colloids, 2007, Jan-16, Volume: 23, Issue:2

    Topics: 1,2-Dipalmitoylphosphatidylcholine; Chemistry, Physical; Hydrocarbons; Lysophosphatidylcholines; Lysophospholipids; Membranes; Microscopy, Phase-Contrast; Molecular Conformation; Phosphatidylcholines; Sodium Dodecyl Sulfate; Unilamellar Liposomes; Water

2007
Linoleoyl lysophosphatidic acid and linoleoyl lysophosphatidylcholine are efficient substrates for mammalian lipoxygenases.
    Biochimica et biophysica acta, 2007, Volume: 1770, Issue:7

    Topics: Animals; Chromatography, High Pressure Liquid; Isoenzymes; Kinetics; Lipoxygenase; Lysophosphatidylcholines; Lysophospholipids; Mammals; Oxygen; Spectrometry, Mass, Electrospray Ionization

2007
Suppression of lysophosphatidic acid and lysophosphatidylcholine formation in the plasma in vitro: proposal of a plasma sample preparation method for laboratory testing of these lipids.
    Analytical biochemistry, 2007, Aug-01, Volume: 367, Issue:1

    Topics: Adenosine; Adult; Anticoagulants; beta-Thromboglobulin; Blood Chemical Analysis; Citric Acid; Dipyridamole; Edetic Acid; Humans; In Vitro Techniques; Lysophosphatidylcholines; Lysophospholipids; Multienzyme Complexes; Phosphatidylcholine-Sterol O-Acyltransferase; Phosphodiesterase I; Phosphoric Diester Hydrolases; Platelet Activation; Pyrophosphatases; Theophylline

2007
Identification of an insulin-regulated lysophospholipase with homology to neuropathy target esterase.
    The Journal of biological chemistry, 2008, Feb-29, Volume: 283, Issue:9

    Topics: 3T3-L1 Cells; Animals; Axons; Brain; Carboxylic Ester Hydrolases; Dose-Response Relationship, Drug; Endoplasmic Reticulum; Fasting; Gene Expression Regulation, Enzymologic; Hypoglycemic Agents; Insulin; Lipid Metabolism; Lysophosphatidylcholines; Lysophospholipase; Lysophospholipids; Male; Mice; Organ Specificity; Paralysis; RNA, Messenger; Substrate Specificity; Syndrome

2008
Murine and human autotaxin alpha, beta, and gamma isoforms: gene organization, tissue distribution, and biochemical characterization.
    The Journal of biological chemistry, 2008, Mar-21, Volume: 283, Issue:12

    Topics: Animals; Anthracenes; Base Sequence; Chlorocebus aethiops; CHO Cells; COS Cells; Cricetinae; Cricetulus; Enzyme Inhibitors; Gene Expression Regulation, Enzymologic; Humans; Isoenzymes; Lysophosphatidylcholines; Lysophospholipids; Mice; Molecular Sequence Data; Multienzyme Complexes; Organ Specificity; Perylene; Phosphodiesterase I; Phosphoric Diester Hydrolases; Pyrophosphatases; Substrate Specificity

2008
Lysophosphatidylcholine induces neuropathic pain through an action of autotaxin to generate lysophosphatidic acid.
    Neuroscience, 2008, Mar-18, Volume: 152, Issue:2

    Topics: Animals; Dose-Response Relationship, Drug; Hyperalgesia; Lysophosphatidylcholines; Lysophospholipids; Male; Mice; Mice, Knockout; Multienzyme Complexes; Pain Measurement; Phosphodiesterase I; Phosphoric Diester Hydrolases; Pyrophosphatases; Reaction Time; Receptors, Lysophosphatidic Acid; Time Factors

2008
Simultaneous stimulation of spinal NK1 and NMDA receptors produces LPC which undergoes ATX-mediated conversion to LPA, an initiator of neuropathic pain.
    Journal of neurochemistry, 2008, Volume: 107, Issue:6

    Topics: Afferent Pathways; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Analysis of Variance; Animals; Calcitonin Gene-Related Peptide; Capsaicin; Cell Line, Transformed; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; In Vitro Techniques; Lysophosphatidylcholines; Lysophospholipids; Mice; Multienzyme Complexes; N-Methylaspartate; Phosphodiesterase I; Phospholipases A2; Phosphoric Diester Hydrolases; Protein Kinase C; Pyrophosphatases; Receptors, Lysophosphatidic Acid; Receptors, N-Methyl-D-Aspartate; Receptors, Neurokinin-1; Signal Transduction; Spinal Cord; Substance P

2008
Autotaxin protects MCF-7 breast cancer and MDA-MB-435 melanoma cells against Taxol-induced apoptosis.
    Oncogene, 2009, Feb-19, Volume: 28, Issue:7

    Topics: Apoptosis; Blotting, Western; Breast Neoplasms; Cell Cycle; Cell Line, Tumor; Ceramides; Humans; Lysophosphatidylcholines; Lysophospholipids; Melanoma; Membrane Potential, Mitochondrial; Multienzyme Complexes; Paclitaxel; Phosphodiesterase I; Phosphoric Diester Hydrolases; Pyrophosphatases; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger

2009
Lysophosphatidyl choline modulates mechanosensitive L-type Ca2+ current in circular smooth muscle cells from human jejunum.
    American journal of physiology. Gastrointestinal and liver physiology, 2009, Volume: 296, Issue:4

    Topics: Action Potentials; Calcium Channels, L-Type; Humans; Jejunum; Lysophosphatidylcholines; Lysophospholipids; Mechanotransduction, Cellular; Models, Molecular; Myocytes, Smooth Muscle

2009
Inhibition of autotaxin production or activity blocks lysophosphatidylcholine-induced migration of human breast cancer and melanoma cells.
    Molecular carcinogenesis, 2009, Volume: 48, Issue:9

    Topics: Anilides; Blotting, Western; Breast Neoplasms; Catalysis; Cell Line; Cell Line, Tumor; Cell Movement; Enzyme Inhibitors; Humans; Kinetics; Lysophosphatidylcholines; Lysophospholipids; Melanoma; Multienzyme Complexes; Organophosphates; Organophosphonates; Phosphodiesterase I; Phosphoric Diester Hydrolases; Pyridines; Pyrophosphatases; Receptors, Lysophosphatidic Acid; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; RNA, Small Interfering; Transfection

2009
Altered activity of lysophospholipase D, which produces bioactive lysophosphatidic acid and choline, in serum from women with pathological pregnancy.
    Molecular human reproduction, 2009, Volume: 15, Issue:5

    Topics: Animals; Choline; Female; Gestational Age; Humans; Lysophosphatidylcholines; Lysophospholipids; Multienzyme Complexes; Obstetric Labor, Premature; Phosphodiesterase I; Phosphoric Diester Hydrolases; Phosphoric Monoester Hydrolases; Pre-Eclampsia; Pregnancy; Pyrophosphatases

2009
Autotaxin structure-activity relationships revealed through lysophosphatidylcholine analogs.
    Bioorganic & medicinal chemistry, 2009, May-01, Volume: 17, Issue:9

    Topics: Cell Line, Tumor; Humans; Hydrolysis; Lysophosphatidylcholines; Lysophospholipids; Multienzyme Complexes; Phosphodiesterase I; Phosphoric Diester Hydrolases; Pyrophosphatases; Receptors, Lysophosphatidic Acid; Structure-Activity Relationship

2009
Measurement of endogenous lysophosphatidic acid by ESI-MS/MS in plasma samples requires pre-separation of lysophosphatidylcholine.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2009, Nov-01, Volume: 877, Issue:29

    Topics: Humans; Lysophosphatidylcholines; Lysophospholipids; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry

2009
Lysophosphatidic acid-3 receptor-mediated feed-forward production of lysophosphatidic acid: an initiator of nerve injury-induced neuropathic pain.
    Molecular pain, 2009, Nov-13, Volume: 5

    Topics: Animals; Cell Line, Tumor; Ganglia, Spinal; Hyperalgesia; In Vitro Techniques; Lysophosphatidylcholines; Lysophospholipids; Male; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Multienzyme Complexes; Neuralgia; Phosphodiesterase I; Phosphoric Diester Hydrolases; Posterior Horn Cells; Pyrophosphatases; Rats; Receptors, Lysophosphatidic Acid; Reverse Transcriptase Polymerase Chain Reaction; Spinal Cord; Spinal Nerve Roots

2009
Hepatocellular carcinoma associated lipid metabolism reprogramming.
    The Journal of surgical research, 2011, Volume: 169, Issue:1

    Topics: Bile; Carcinoma, Hepatocellular; Case-Control Studies; Choline; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Humans; Lipid Metabolism; Liver; Liver Neoplasms; Lysophosphatidylcholines; Lysophospholipids; Phospholipids; Receptors, G-Protein-Coupled

2011
Optimization of a pipemidic acid autotaxin inhibitor.
    Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3

    Topics: Breast Neoplasms; Computer-Aided Design; Drug Evaluation, Preclinical; Enzyme Assays; Enzyme Inhibitors; Female; Humans; Lysophosphatidylcholines; Lysophospholipids; Multienzyme Complexes; Phosphodiesterase I; Phosphoric Diester Hydrolases; Pipemidic Acid; Pyrophosphatases; Quantitative Structure-Activity Relationship; Tumor Cells, Cultured

2010
Evidence for de novo synthesis of lysophosphatidic acid in the spinal cord through phospholipase A2 and autotaxin in nerve injury-induced neuropathic pain.
    The Journal of pharmacology and experimental therapeutics, 2010, Volume: 333, Issue:2

    Topics: Animals; Arachidonic Acids; Blotting, Western; Cell Line; Injections, Spinal; Lysophosphatidylcholines; Lysophospholipids; Male; Mice; Mice, Inbred C57BL; Multienzyme Complexes; Naphthalenes; Neuralgia; Pain Measurement; Phosphodiesterase I; Phospholipase A2 Inhibitors; Phospholipases A2; Phosphoric Diester Hydrolases; Posterior Horn Cells; Pyrones; Pyrophosphatases; Sciatic Nerve; Spinal Nerve Roots

2010
Pre-emptive morphine treatment abolishes nerve injury-induced lysophospholipid synthesis in mass spectrometrical analysis.
    Journal of neurochemistry, 2011, Volume: 118, Issue:2

    Topics: Animals; Lysophosphatidylcholines; Lysophospholipids; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Morphine; Sciatic Neuropathy; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Treatment Outcome

2011
Ligand-based autotaxin pharmacophore models reflect structure-based docking results.
    Journal of molecular graphics & modelling, 2011, Volume: 31

    Topics: Binding, Competitive; Catalytic Domain; Drug Design; Humans; Ligands; Lysophosphatidylcholines; Lysophospholipids; Models, Molecular; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Protein Binding

2011
Identification and biochemical characterization of a novel autotaxin isoform, ATXδ, with a four-amino acid deletion.
    Journal of biochemistry, 2012, Volume: 151, Issue:1

    Topics: Alternative Splicing; Amino Acid Sequence; Amino Acids; Animals; Base Sequence; Biocatalysis; Blotting, Western; Cloning, Molecular; Female; Gene Expression Profiling; Gene Expression Regulation, Enzymologic; HEK293 Cells; Humans; Hydrolysis; Isoenzymes; Lysophosphatidylcholines; Lysophospholipids; Male; Molecular Sequence Data; Phosphoric Diester Hydrolases; Reverse Transcriptase Polymerase Chain Reaction; Sequence Deletion; Sequence Homology, Amino Acid; Sequence Homology, Nucleic Acid

2012
Evidence supporting a key role of Lp-PLA2-generated lysophosphatidylcholine in human atherosclerotic plaque inflammation.
    Arteriosclerosis, thrombosis, and vascular biology, 2012, Volume: 32, Issue:6

    Topics: 1-Alkyl-2-acetylglycerophosphocholine Esterase; Aged; Biomarkers; Biopsy; Carotid Stenosis; Cytokines; Enzyme-Linked Immunosorbent Assay; Female; Humans; Immunohistochemistry; Inflammation; Inflammation Mediators; Lysophosphatidylcholines; Lysophospholipids; Macrophages; Male; Mass Spectrometry; Middle Aged; Muscle, Smooth, Vascular; Phospholipases A2; Plaque, Atherosclerotic; Severity of Illness Index; T-Lymphocytes

2012
Decrease in circulating autotaxin by oral administration of prednisolone.
    Clinica chimica acta; international journal of clinical chemistry, 2013, Jan-16, Volume: 415

    Topics: Adipose Tissue; Administration, Oral; Animals; Autoimmune Diseases; Biomarkers, Pharmacological; Case-Control Studies; Female; Gene Expression; Glucocorticoids; Humans; Immunoenzyme Techniques; Lysophosphatidylcholines; Lysophospholipids; Male; Mice; Mice, Inbred C57BL; Phosphoric Diester Hydrolases; Prednisolone; Real-Time Polymerase Chain Reaction; Signal Transduction; Tissue Culture Techniques

2013
Protection of the membrane permeability barrier by annexins.
    Biochemistry, 2012, Dec-18, Volume: 51, Issue:50

    Topics: Amyloid beta-Peptides; Annexin A5; Annexin A6; Annexins; Arachidonic Acid; Calcium; Cell Membrane; Cell Membrane Permeability; Diglycerides; Fluoresceins; Humans; Islet Amyloid Polypeptide; Lipid Bilayers; Lysophosphatidylcholines; Lysophospholipids; Monoglycerides; Osmotic Pressure; Peptide Fragments; Spermidine; Unilamellar Liposomes

2012
Constitutive lymphocyte transmigration across the basal lamina of high endothelial venules is regulated by the autotaxin/lysophosphatidic acid axis.
    Journal of immunology (Baltimore, Md. : 1950), 2013, Mar-01, Volume: 190, Issue:5

    Topics: Animals; Basement Membrane; Endothelium; Enzyme Inhibitors; Female; Gene Expression; Lymph Nodes; Lymphocytes; Lysophosphatidylcholines; Lysophospholipids; Mice; Mice, Inbred C57BL; Myosin Type II; Phosphoric Diester Hydrolases; Receptors, Lysophosphatidic Acid; Signal Transduction; Spleen; Transendothelial and Transepithelial Migration; Venules

2013
Autotaxin is expressed in FLT3-ITD positive acute myeloid leukemia and hematopoietic stem cells and promotes cell migration and proliferation.
    Experimental hematology, 2013, Volume: 41, Issue:5

    Topics: Acute Disease; Blotting, Western; Cell Line; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cells, Cultured; fms-Like Tyrosine Kinase 3; Gene Expression Profiling; Gene Expression Regulation, Leukemic; Hematopoietic Stem Cells; Humans; Indoles; K562 Cells; Leukemia, Myeloid; Lysophosphatidylcholines; Lysophospholipids; Mutation; Oligonucleotide Array Sequence Analysis; Phosphoric Diester Hydrolases; Protein Kinase Inhibitors; Reverse Transcriptase Polymerase Chain Reaction; Staurosporine; Tandem Repeat Sequences

2013
Inhibition of lysophosphatidic acid increase by prestorage whole blood leukoreduction in autologous CPDA-1 whole blood.
    Transfusion, 2013, Volume: 53, Issue:12

    Topics: Acute Lung Injury; Blood Preservation; Humans; Lysophosphatidylcholines; Lysophospholipids; Transfusion Reaction

2013
The pathological effects of Heminecrolysin, a dermonecrotic toxin from Hemiscorpius lepturus scorpion venom are mediated through its lysophospholipase D activity.
    Toxicon : official journal of the International Society on Toxinology, 2013, Volume: 68

    Topics: Animals; Chick Embryo; Choline; Erythrocytes; Glycophorins; Hemolysis; Humans; Interleukin-10; Interleukin-6; Jurkat Cells; Lysophosphatidylcholines; Lysophospholipids; Phosphatidylserines; Phosphoric Diester Hydrolases; Scorpion Venoms; Scorpions; Spiders; Tumor Necrosis Factor-alpha

2013
Increased lysophosphatidic acid levels in culprit coronary arteries of patients with acute coronary syndrome.
    Atherosclerosis, 2013, Volume: 229, Issue:1

    Topics: Acute Coronary Syndrome; Aged; Coronary Artery Disease; Coronary Circulation; Coronary Thrombosis; Cross-Sectional Studies; Female; Humans; Lipids; Lysophosphatidylcholines; Lysophospholipids; Male; Middle Aged; Platelet Activation; Prospective Studies

2013
Activation of bile salt dependent lipase by (lyso)phosphatidic acid and platelet activating factor.
    FEBS letters, 2013, Sep-17, Volume: 587, Issue:18

    Topics: Binding Sites; Enzyme Activation; Enzyme Assays; Female; Humans; Kinetics; Lipase; Lysophosphatidylcholines; Lysophospholipids; Milk, Human; Phosphatidic Acids; Phosphatidylcholines; Platelet Activating Factor; Protein Binding; Taurocholic Acid

2013
Non-invasive imaging of tumors by monitoring autotaxin activity using an enzyme-activated near-infrared fluorogenic substrate.
    PloS one, 2013, Volume: 8, Issue:11

    Topics: Animals; Chlorocebus aethiops; COS Cells; Female; Fluorescent Dyes; Lysophosphatidylcholines; Lysophospholipids; Mice; Mice, Nude; Phosphoric Diester Hydrolases; Xenograft Model Antitumor Assays

2013
Bioactive lipids, LPC and LPA, are novel prometastatic factors and their tissue levels increase in response to radio/chemotherapy.
    Molecular cancer research : MCR, 2014, Volume: 12, Issue:11

    Topics: Animals; Bone Marrow; Cell Adhesion; Cell Line, Tumor; Cell Movement; Cell Survival; Chemotactic Factors; Drug Resistance, Neoplasm; Gamma Rays; Humans; Isoxazoles; Lysophosphatidylcholines; Lysophospholipids; MAP Kinase Signaling System; Mice, Inbred C57BL; Mice, SCID; Neoplasm Metastasis; Propionates; Receptors, G-Protein-Coupled; Rhabdomyosarcoma; Tumor Microenvironment; Vincristine

2014
Source and role of intestinally derived lysophosphatidic acid in dyslipidemia and atherosclerosis.
    Journal of lipid research, 2015, Volume: 56, Issue:4

    Topics: Animals; Aorta; Atherosclerosis; Benzoxazoles; Dietary Fats; Dyslipidemias; Female; Group IB Phospholipases A2; Intestinal Absorption; Intestinal Mucosa; Intestines; Jejunum; Liver; Lysophosphatidylcholines; Lysophospholipids; Male; Mice; Phosphoric Diester Hydrolases; Piperazines; Receptors, LDL

2015
Lysophosphatidic acid generation by pulmonary NKT cell ENPP-2/autotaxin exacerbates hyperoxic lung injury.
    Purinergic signalling, 2015, Volume: 11, Issue:4

    Topics: Acute Lung Injury; Animals; Cell Count; Hyperoxia; Inflammation; Lung; Lysophosphatidylcholines; Lysophospholipids; Mice; Mice, Inbred C57BL; Natural Killer T-Cells; Oxygen; Phosphoric Diester Hydrolases; Receptors, Purinergic P2X7; Up-Regulation

2015
Discovery and synthetic optimization of a novel scaffold for hydrophobic tunnel-targeted autotaxin inhibition.
    Bioorganic & medicinal chemistry, 2016, 10-01, Volume: 24, Issue:19

    Topics: Animals; Enzyme Inhibitors; Humans; Hydrophobic and Hydrophilic Interactions; Lysophosphatidylcholines; Lysophospholipids; Mice; Molecular Docking Simulation; Phosphoric Diester Hydrolases; Quantitative Structure-Activity Relationship

2016
Identification and pharmacological characterization of a novel inhibitor of autotaxin in rodent models of joint pain.
    Osteoarthritis and cartilage, 2017, Volume: 25, Issue:6

    Topics: Animals; Arthralgia; Arthritis, Experimental; Dogs; Humans; Iodoacetic Acid; Lysophosphatidylcholines; Lysophospholipids; Male; Menisci, Tibial; Osteoarthritis, Knee; Osteotomy; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Rats; Rats, Inbred Lew; Tibial Meniscus Injuries

2017
Urinary lysophopholipids are increased in diabetic patients with nephropathy.
    Journal of diabetes and its complications, 2017, Volume: 31, Issue:7

    Topics: Aged; Albuminuria; Biomarkers; Case-Control Studies; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Female; Glomerular Filtration Rate; Humans; Kidney; Lysophosphatidylcholines; Lysophospholipids; Male; Middle Aged; Pilot Projects; Renal Elimination; Renal Insufficiency; Severity of Illness Index; Up-Regulation

2017
Discovery, Structure-Activity Relationship, and Binding Mode of an Imidazo[1,2-a]pyridine Series of Autotaxin Inhibitors.
    Journal of medicinal chemistry, 2017, 09-14, Volume: 60, Issue:17

    Topics: Animals; Humans; Imidazoles; Lysophosphatidylcholines; Lysophospholipids; Male; Mice; Molecular Docking Simulation; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pyridines; Rats; Rats, Sprague-Dawley; Structure-Activity Relationship

2017
Autotaxin-Lysophosphatidic Acid Pathway in Intraocular Pressure Regulation and Glaucoma Subtypes.
    Investigative ophthalmology & visual science, 2018, 02-01, Volume: 59, Issue:2

    Topics: Adult; Aged; Aged, 80 and over; Aqueous Humor; Chromatography, Liquid; Exfoliation Syndrome; Female; Glaucoma, Open-Angle; Gonioscopy; Healthy Volunteers; Humans; Intraocular Pressure; Low Tension Glaucoma; Lysophosphatidylcholines; Lysophospholipids; Male; Middle Aged; Phosphoric Diester Hydrolases; Tandem Mass Spectrometry; Tonometry, Ocular

2018
Measurement of plasma choline in acute coronary syndrome: importance of suitable sampling conditions for this assay.
    Scientific reports, 2018, 03-16, Volume: 8, Issue:1

    Topics: Acute Coronary Syndrome; Aged; Animals; Biological Assay; Biomarkers; Case-Control Studies; Choline; Female; Humans; Lysophosphatidylcholines; Lysophospholipids; Male; Mice; Mice, Knockout; Middle Aged; Phosphoric Diester Hydrolases

2018
Plasma lipidomic signatures of spontaneous obese rhesus monkeys.
    Lipids in health and disease, 2019, Jan-08, Volume: 18, Issue:1

    Topics: Animals; Case-Control Studies; Fatty Acids, Nonesterified; Female; Gas Chromatography-Mass Spectrometry; Lipid Metabolism; Lysophosphatidylcholines; Lysophospholipids; Macaca mulatta; Metabolome; Obesity; Phosphatidylcholines; Phosphatidylethanolamines; Phosphatidylglycerols; Phosphatidylinositols; Phosphatidylserines; Sphingomyelins

2019
Associations between plasma lysophospholipids concentrations, chronic kidney disease and the type of renal replacement therapy.
    Lipids in health and disease, 2019, Apr-04, Volume: 18, Issue:1

    Topics: Adult; Aged; Correlation of Data; Female; Humans; Kidney; Kidney Transplantation; Lysophosphatidylcholines; Lysophospholipids; Male; Middle Aged; Peritoneal Dialysis; Renal Dialysis; Renal Insufficiency, Chronic; Renal Replacement Therapy

2019
Benzoxaboroles-Novel Autotaxin Inhibitors.
    Molecules (Basel, Switzerland), 2019, Sep-20, Volume: 24, Issue:19

    Topics: Animals; Humans; Lysophosphatidylcholines; Lysophospholipids; Neoplasms; Phosphoric Diester Hydrolases; Rats; Structure-Activity Relationship

2019
Alteration of the lysophosphatidic acid and its precursor lysophosphatidylcholine levels in spinal cord stenosis: A study using a rat cauda equina compression model.
    Scientific reports, 2019, 11-12, Volume: 9, Issue:1

    Topics: Animals; Cauda Equina; Constriction, Pathologic; Disease Models, Animal; Female; Gene Expression Regulation; Lysophosphatidylcholines; Lysophospholipids; Neuralgia; Rats, Sprague-Dawley; Receptors, Lysophosphatidic Acid; RNA, Messenger; Spinal Cord

2019
Protective effect of Ganoderma atrum polysaccharides in acute lung injury rats and its metabolomics.
    International journal of biological macromolecules, 2020, Jan-01, Volume: 142

    Topics: Acute Lung Injury; Animals; Anti-Inflammatory Agents; Biomarkers; Chromatography, High Pressure Liquid; Cytokines; Disease Models, Animal; Fatty Acids, Volatile; Ganoderma; Histidine; Lysophosphatidylcholines; Lysophospholipids; Male; Metabolomics; Polysaccharides; Rats; Rats, Sprague-Dawley; Signal Transduction; Tandem Mass Spectrometry; Taurocholic Acid; Tryptophan

2020
A conjunctive lipidomic approach reveals plasma ethanolamine plasmalogens and fatty acids as early diagnostic biomarkers for colorectal cancer patients.
    Expert review of proteomics, 2020, Volume: 17, Issue:3

    Topics: Aged; Ceramides; Cholesterol; Colorectal Neoplasms; Early Detection of Cancer; Female; Humans; Lipidomics; Lipoproteins, HDL; Lipoproteins, LDL; Lysophosphatidylcholines; Lysophospholipids; Male; Middle Aged; Plasmalogens; Sphingosine; Triglycerides

2020
Distinct contributions of two choline-producing enzymatic activities to lysophosphatidic acid production in human amniotic fluid from pregnant women in the second trimester and after parturition.
    Prostaglandins & other lipid mediators, 2020, Volume: 150

    Topics: Amniotic Fluid; Choline; Female; Humans; Lysophosphatidylcholines; Lysophospholipids; Parturition; Phosphoric Diester Hydrolases; Pregnancy; Pregnancy Trimester, Second

2020
Inhibition of autotaxin activity ameliorates neuropathic pain derived from lumbar spinal canal stenosis.
    Scientific reports, 2021, 02-17, Volume: 11, Issue:1

    Topics: Animals; Behavior, Animal; Carbolines; Cerebrospinal Fluid; Disease Models, Animal; Female; Ganglia, Spinal; Humans; Lysophosphatidylcholines; Lysophospholipids; Mice; Neuralgia; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Rats, Sprague-Dawley; Spinal Canal; Spinal Stenosis

2021
Lysophosphatidic acid production from lysophosphatidylcholine by lysophospholipase D activity of autotaxin in plasma of women with normal and adverse pregnancies.
    Prostaglandins & other lipid mediators, 2022, Volume: 163

    Topics: Female; Humans; Infant, Newborn; Lysophosphatidylcholines; Lysophospholipids; Phosphoric Diester Hydrolases; Pregnancy

2022
Linking medicinal cannabis to autotaxin-lysophosphatidic acid signaling.
    Life science alliance, 2023, Volume: 6, Issue:2

    Topics: Dronabinol; Lysophosphatidylcholines; Lysophospholipids; Medical Marijuana; Receptors, Lysophosphatidic Acid

2023
Modes of action of lysophospholipids as endogenous activators of the TRPV4 ion channel.
    The Journal of physiology, 2023, Volume: 601, Issue:9

    Topics: Lysophosphatidylcholines; Lysophospholipids; Transient Receptor Potential Channels; TRPV Cation Channels

2023
Hypoxia increases cellular levels of phosphatidic acid and lysophospholipids in undifferentiated Caco-2 cells.
    Lipids, 2023, Volume: 58, Issue:2

    Topics: Caco-2 Cells; Humans; Lysophosphatidylcholines; Lysophospholipids; Phosphatidic Acids

2023