Compounds > lysophosphatidic acid
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lysophosphatidic acid and isoxazoles

lysophosphatidic acid has been researched along with isoxazoles in 69 studies

Research

Studies (69)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's29 (42.03)29.6817
2010's35 (50.72)24.3611
2020's5 (7.25)2.80

Authors

AuthorsStudies
Aoki, J; Arai, H; Chun, J; Fukaya, M; Hama, K; Kishi, Y; Ohta, H; Sakai, T; Suzuki, R; Watanabe, M; Yamori, T1
Hayashi, K; Inoue, K; Ishikawa, K; Malchinkhuu, E; Mochiduki, A; Mogi, C; Muraki, T; Nochi, H; Okajima, F; Sato, K; Tamoto, K; Tomura, H; Tosaka, M1
Kitayama, J; Nagawa, H; Ohta, H; Sakai, T; Sako, A; Shida, D; Suzuki, R1
Bast, RC; Fang, X; Lee, Z; Liang, Y; Liu, S; Lu, KH; Mills, GB; Swaby, RF; Yu, S1
Moughal, NA; Natarajan, V; Pyne, NJ; Pyne, S; Saatian, B; Tigyi, G; Waters, CM; Zhao, Y1
Liu, Z; Meier, KE; Zhang, Z1
Bordet, JC; Boucharaba, A; Clézardin, P; Guglielmi, J; Peyruchaud, O; Serre, CM1
Gidley, J; Mansell, JP; Openshaw, S; Pring, ET; Sale, S1
Baldini, PM; Carotenuto, F; Chiurchiu', V; D'Aquilio, F; Di Nardo, P; Giambra, V; Izzi, V; Procaccini, M2
Asari, S; Chiba, A; Fujita, K; Fukuchi, N; Iida, Y; Ijichi, C; Iwayama, S; Kataba, Y; Ohmuta, N; Ohsumi, K; Shoji, M; Yamamoto, T1
Chen, M; O'Connor, KL; Towers, LN1
Bae, YS; Chang, YJ; Han, M; Im, DS; Kim, HL; Kim, K; Kim, YL; Lee, YK; Okajima, F; Sacket, SJ1
Bae, YS; Kim, SD; Lee, HY; Lee, SY; Shim, JW1
Baba, K; Fujita, N; Ito, M; Shiraishi, A; Tabata, K1
Aki, Y; Kondo, A; Nakamura, H; Togari, A1
Kim, J; Lim, S; Park, HS; Park, KS; Ryu, SH; Suh, PG; Yea, K1
Bascands, JL; Calise, D; Chun, J; Grès, S; Guigné, C; Klein, J; Neau, E; Pradère, JP; Saulnier-Blache, JS; Schanstra, JP; Valet, P1
Chen, J; Fang, X; Gibson, SB; Graham, BA; Hu, X; Ishdorj, G; Johnston, JB1
Han, M; Im, DS; Jo, JY; Kim, HL; Kim, K; Kim, YL; Lee, YK; Sacket, SJ1
Fells, JI; Fujiwara, Y; Liu, J; Osborne, DA; Parrill, AL; Perygin, DH; Tigyi, G; Tsukahara, R1
Chang, YJ; Im, DS; Jo, JY; Kim, HL; Kim, YL; Kyeok, K1
Hanibuchi, M; Ikuta, K; Kakiuchi, S; Kanematsu, T; Ogino, H; Sekido, Y; Sone, S; Taniguchi, T; Yamada, T; Yano, S1
Kobayashi, T; Nochi, H; Ohta, H; Okajima, F; Sato, K; Shinozaki, T; Takagishi, K; Tamoto, K; Tanaka, N; Tobo, M; Tomura, H1
Bah, MM; Brzezicka, E; Komiyama, J; Okuda, K; Saulnier-Blache, JS; Skarzynski, DJ; Woclawek-Potocka, I1
Im, DS; Kimura, T; Komachi, M; Kurose, H; Kuwabara, A; Malchinkhuu, E; Mogi, C; Ohta, H; Okajima, F; Sato, K; Takeyoshi, I; Tobo, M; Tomura, H; Yamada, T1
Hooks, SB; Hurst, JH1
Kondraciuk, K; Skarzynski, DJ; Woclawek-Potocka, I1
Cerutis, DR; George, J; Headen, KV; Mattson, JS; McVaney, TP; Ogunleye, AO; Parrish, LC; Perry, GA; Wilwerding, TM1
Fraser, PA; Hu, DE; Sarker, MH1
Chun, J; Dubin, AE; Herr, DR1
Nie, W; Rodriguez Perez, CE; Rozengurt, E; Sinnett-Smith, J; Yoo, J1
Berdyshev, E; Chun, J; He, D; Natarajan, V; Su, Y; Zhao, J; Zhao, Y1
Chen, SS; Chiang, CL; Chu, PL; Hwang, SM; Lee, H; Lee, SJ; Tsao, KC; Wen, CH; Yao, CL1
Im, DS; Ishii, S; Kimura, T; Komachi, M; Mogi, C; Ohta, H; Okajima, F; Sato, K; Takeyoshi, I; Tobo, M; Tomura, H; Yamada, T; Yanagida, K1
Gibbs, TC; Knoepp, SM; Meier, KE; Park, JJ; Rubio, MV; Snider, AJ; Um, T; Xie, Y; Zhang, Z1
Albers, HM; Houben, AJ; Lai, SL; Lee, SJ; Moolenaar, WH; Ovaa, H; Tsao, KC; Yao, WL1
Chun, J; Duffield, JS; Luster, AD; Sakai, N; Tager, AM; Wada, T1
Attané, C; Bertrand, C; Dusaulcy, R; Fournel, A; Grès, S; Prentki, M; Rancoule, C; Saulnier-Blache, JS; Tréguer, K; Valet, P; Vinel, C1
Chen, X; Cong, X; Li, Z; Wang, F; Wang, X; Wei, H; Yang, J1
Castilla-Ortega, E; Chun, J; Estivill-Torrús, G; García-Fernández, M; Pedraza, C; Rodriguez de Fonseca, F; Rosell-Valle, C; Sánchez-López, J; Santín, LJ; Zambrana-Infantes, E1
Bae, YS; Chung, HY; Im, DS; Kang, S; Lee, KP; Okajima, F; Park, SJ1
Heo, SC; Jeong, GO; Kim, JH; Kim, KH; Kwon, YW; Seo, EJ; Shin, SH; Suh, DS; Yoon, MS1
Bascands, JL; Bouloumié, A; Decaunes, P; Gres, S; Langin, D; Rancoule, C; Saulnier-Blache, JS; Valet, P; Viaud, M; Viguerie, N1
An, MS; Ding, Q; Feng, R; Li, L; Liu, Y; Tang, N; Wang, S; Wei, W; Wen, J; Zhao, Y1
Georas, SN; Knowlden, S1
Aoki, J; Hama, K; Inoue, A; Kano, K; Kawahara, A; Nakanaga, K; Nishina, H; Saigusa, D; Sato, T; Tokuyama, H; Tomioka, Y; Yukiura, H1
Clézardin, P; David, M; Descotes, F; Leblanc, R; Mege, F; Peyruchaud, O; Ribeiro, J; Sahay, D1
Katakai, T; Kinashi, T; Kondo, N; Ueda, Y1
Caeiro, JR; Conde, C; Gómez-Reino, JJ; González, A; Guede, D; Martínez, P; Orosa, B1
Abdel-Latif, A; Morris, AJ; Ratajczak, MZ; Schneider, G; Sellers, ZP1
Harigai, M; Iwai, Y; Miyabe, C; Miyabe, Y; Miyasaka, M; Miyasaka, N; Nanki, T; Sekine, C; Sugimoto, K; Yokoyama, W1
Furukawa, S; Handa, H; Hashimoto, A; Hashimoto, S; Mikami, S; Oikawa, T; Okada, Y; Onodera, Y; Oya, M; Sabe, H; Sugino, H; Yoshikawa, A1
Lin, W; Liu, BL; Pan, HL; Zhang, YQ1
Albacete, S; Bui, HH; Chambers, MG; Lin, C; McDougall, JJ; Mitchell, PG; Oskins, JL; Schuelert, N1
Bot, I; Kritikou, E; Kröner, MJ; Kuiper, J; Schaftenaar, FH; Swart, M; van der Heijden, T; van Puijvelde, GH; van Santbrink, PJ1
Choi, JW; Jun, HS; Jung, JY; Li, HY; Oh, YS1
An, D; Chun, J; Cui, MZ; Hao, F; Kong, W; Xu, X; Zhang, F1
Guan, M; Li, N; Song, J; Sun, S; Wang, R; Zhang, J; Zhang, X; Zhao, Z1
Bae, GH; Bae, YS; Kim, HS; Lee, HY; Lee, M; Lee, SK1
Chen, C; Du, L; Han, C; Li, X; Qin, A; Zhang, K; Zhao, C; Zhao, J; Zhou, T1
Aidinis, V; Budd, DC; Kaffe, E; Müller, S; Ninou, I; Stevenson, CS; Ullmer, C1
Dietze, R; Konrad, L; Meinhold-Heerlein, I; Scheiner-Bobis, G; Starzinski-Powitz, A; Tinneberg, HR1
Blaho, VA; Chun, J; Frantz, AJ; Kennedy, G; Kihara, Y; Lummis, NC; Sánchez-Pavón, P1
Bao, G; Damirin, A; Li, Y; Ma, Q; Pei, JY; Sun, HJ; Wang, YW; Wu, S; Zhao, PF1
Goh, YJ; Hwang, SH; Won, KJ1
Hirata, T; Miyata, N; Roman, RJ; Smith, SV; Takahashi, T1
Adner, M; Högberg, J; Stenius, U; Wu, R; Zheng, H1
Cheon, J; Jun, HS; Kim, D; Lee, GH1

Reviews

1 review(s) available for lysophosphatidic acid and isoxazoles

ArticleYear
The autotaxin-LPA axis emerges as a novel regulator of lymphocyte homing and inflammation.
    Journal of immunology (Baltimore, Md. : 1950), 2014, Feb-01, Volume: 192, Issue:3

    Topics: Adaptive Immunity; Airway Remodeling; Animals; Antigens; Asthma; Cell Movement; Chemotaxis, Leukocyte; Dendritic Cells; Humans; Inflammation; Isoxazoles; Lymphoid Tissue; Lysophospholipids; Mice; Phosphoric Diester Hydrolases; Propionates; Radiation Chimera; Receptors, Lysophosphatidic Acid; Signal Transduction; T-Lymphocytes; Up-Regulation; Venules

2014

Trials

1 trial(s) available for lysophosphatidic acid and isoxazoles

ArticleYear
Pro-fibrotic activity of lysophosphatidic acid in adipose tissue: in vivo and in vitro evidence.
    Biochimica et biophysica acta, 2014, Volume: 1841, Issue:1

    Topics: Actins; Adipose Tissue; Animals; Collagen; Enzyme Activators; Female; Fibrosis; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Indazoles; Isoxazoles; Lysophospholipids; Male; Mice; Mice, Obese; Propionates; Receptors, Lysophosphatidic Acid; Tissue Culture Techniques; Transforming Growth Factor beta

2014

Other Studies

67 other study(ies) available for lysophosphatidic acid and isoxazoles

ArticleYear
Lysophosphatidic acid and autotaxin stimulate cell motility of neoplastic and non-neoplastic cells through LPA1.
    The Journal of biological chemistry, 2004, Apr-23, Volume: 279, Issue:17

    Topics: Animals; Calcium; Cell Line; Cell Line, Tumor; Cell Movement; Cells, Cultured; Chemotaxis; Dose-Response Relationship, Drug; Fibroblasts; Glucose-6-Phosphate Isomerase; Glycoproteins; Isoxazoles; Lysophospholipids; Mice; Mice, Knockout; Mice, Transgenic; Microscopy, Fluorescence; Models, Biological; Multienzyme Complexes; Neoplasms; Phosphodiesterase I; Phosphoric Diester Hydrolases; Platelet-Derived Growth Factor; Propionates; Pyrophosphatases; rac1 GTP-Binding Protein; Reverse Transcriptase Polymerase Chain Reaction; rhoA GTP-Binding Protein; Signal Transduction; Skin; Time Factors

2004
Identification of autotaxin as a neurite retraction-inducing factor of PC12 cells in cerebrospinal fluid and its possible sources.
    Journal of neurochemistry, 2005, Volume: 92, Issue:4

    Topics: Animals; Cells, Cultured; Dogs; Glucose-6-Phosphate Isomerase; Glycoproteins; Humans; Isoxazoles; Lysophospholipids; Male; Multienzyme Complexes; Neurites; PC12 Cells; Phosphodiesterase I; Phosphoric Diester Hydrolases; Propionates; Pyrophosphatases; Rats; Rats, Wistar; Receptors, Lysophosphatidic Acid

2005
Lysophosphatidic acid (LPA)-induced vascular endothelial growth factor (VEGF) by mesothelial cells and quantification of host-derived VEGF in malignant ascites.
    The Journal of surgical research, 2006, Volume: 130, Issue:1

    Topics: Animals; Ascites; Cell Line, Tumor; Culture Media, Conditioned; Disease Models, Animal; Epithelial Cells; Epithelium; Female; Humans; Isoxazoles; Lysophospholipids; Mice; Mice, Inbred BALB C; Mice, Nude; Pertussis Toxin; Propionates; Receptors, Lysophosphatidic Acid; RNA, Messenger; Stomach Neoplasms; Vascular Endothelial Growth Factor A

2006
Lysophosphatidic acid is a major regulator of growth-regulated oncogene alpha in ovarian cancer.
    Cancer research, 2006, Mar-01, Volume: 66, Issue:5

    Topics: Ascites; Cell Line, Tumor; Chemokine CXCL1; Chemokines, CXC; Down-Regulation; Female; GTP-Binding Protein alpha Subunits, Gi-Go; Humans; Intercellular Signaling Peptides and Proteins; Isoxazoles; Lysophospholipids; Ovarian Neoplasms; Pertussis Toxin; Propionates; Receptors, Lysophosphatidic Acid; Transcriptional Activation

2006
Integrin signalling regulates the nuclear localization and function of the lysophosphatidic acid receptor-1 (LPA1) in mammalian cells.
    The Biochemical journal, 2006, Aug-15, Volume: 398, Issue:1

    Topics: Animals; Cell Count; Cell Nucleus; Cells, Cultured; CHO Cells; Cricetinae; Cricetulus; Epithelial Cells; Humans; Integrins; Intracellular Signaling Peptides and Proteins; Isoxazoles; Lysophospholipids; PC12 Cells; Pertussis Toxin; Phosphorylation; Propionates; Protein Serine-Threonine Kinases; Protein Transport; Rats; Receptors, Lysophosphatidic Acid; rho-Associated Kinases; Signal Transduction

2006
Lysophosphatidic acid as a mediator for proinflammatory agonists in a human corneal epithelial cell line.
    American journal of physiology. Cell physiology, 2006, Volume: 291, Issue:5

    Topics: Cell Line; Cell Proliferation; Cells, Cultured; Cornea; Enzyme Activation; Epithelial Cells; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation; Humans; Inflammation Mediators; Interleukin-1; Isoxazoles; Lipopolysaccharides; Lysophospholipids; p38 Mitogen-Activated Protein Kinases; Propionates; Proto-Oncogene Proteins c-akt; Receptors, Lysophosphatidic Acid; RNA, Messenger; Signal Transduction; Tumor Necrosis Factor-alpha

2006
The type 1 lysophosphatidic acid receptor is a target for therapy in bone metastases.
    Proceedings of the National Academy of Sciences of the United States of America, 2006, Jun-20, Volume: 103, Issue:25

    Topics: Animals; Bone Neoplasms; Cell Line, Tumor; Cell Proliferation; Cytokines; Disease Progression; Female; Gene Expression Regulation, Neoplastic; Humans; Isoxazoles; Lysophospholipids; Mice; Neoplasm Metastasis; Osteoclasts; Propionates; Receptors, Lysophosphatidic Acid

2006
Lysophosphatidic acid cooperates with 1alpha,25(OH)2D3 in stimulating human MG63 osteoblast maturation.
    Prostaglandins & other lipid mediators, 2006, Volume: 80, Issue:1-2

    Topics: Alkaline Phosphatase; Butadienes; Calcitriol; Cell Differentiation; Cells, Cultured; Cyclooxygenase 2; Cytoskeleton; Drug Synergism; Humans; Intracellular Signaling Peptides and Proteins; Isoxazoles; Lysophospholipids; Mitogen-Activated Protein Kinase Kinases; Nitriles; Osteoblasts; Pertussis Toxin; Phosphorylation; Propionates; Protein Serine-Threonine Kinases; rho-Associated Kinases; Stress Fibers

2006
Activatory properties of lysophosphatidic acid on human THP-1 cells.
    Inflammation, 2005, Volume: 29, Issue:4-6

    Topics: Arachidonic Acid; Cell Division; Cell Line; Dinoprostone; Dose-Response Relationship, Drug; Enzyme Activation; Humans; Inflammation Mediators; Isoxazoles; Leukotriene B4; Lysophospholipids; Monocytes; NADPH Oxidases; Propionates; Reactive Oxygen Species; Receptors, Cell Surface

2005
Synthesis and evaluation of isoxazole derivatives as lysophosphatidic acid (LPA) antagonists.
    Bioorganic & medicinal chemistry letters, 2007, Jul-01, Volume: 17, Issue:13

    Topics: Animals; Cell Proliferation; Chemistry, Pharmaceutical; CHO Cells; Cricetinae; Cricetulus; Drug Design; Fibrosis; Humans; Inhibitory Concentration 50; Isoxazoles; Liver; Lysophospholipids; Propionates; Rats

2007
LPA2 (EDG4) mediates Rho-dependent chemotaxis with lower efficacy than LPA1 (EDG2) in breast carcinoma cells.
    American journal of physiology. Cell physiology, 2007, Volume: 292, Issue:5

    Topics: Breast Neoplasms; Cell Line, Tumor; Chemotaxis; Dose-Response Relationship, Drug; Enzyme Activation; Female; Gene Expression Regulation, Neoplastic; Humans; Isoxazoles; Lysophospholipids; Neoplasm Invasiveness; Propionates; Protein Isoforms; Receptors, Lysophosphatidic Acid; rho GTP-Binding Proteins; RNA Interference; RNA, Messenger; RNA, Small Interfering; Signal Transduction

2007
Dioleoyl phosphatidic acid increases intracellular Ca2+ through endogenous LPA receptors in C6 glioma and L2071 fibroblasts.
    Prostaglandins & other lipid mediators, 2007, Volume: 83, Issue:4

    Topics: Animals; Calcium; Cell Line, Tumor; Dose-Response Relationship, Drug; Fibroblasts; Gene Expression; Glioma; Isoxazoles; Lysophospholipids; Mice; Pertussis Toxin; Phosphatidic Acids; Propionates; Rats; Receptors, Lysophosphatidic Acid; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Time Factors

2007
Activatory properties of lysophosphatidic acid on human THP-1 cells.
    Inflammation, 2007, Volume: 30, Issue:5

    Topics: Arachidonic Acid; Cell Line; Cell Proliferation; Dinoprostone; DNA Replication; Enzyme Activation; Humans; Inflammation; Inflammation Mediators; Isoxazoles; Leukotriene B4; Lysophospholipids; Monocytes; NADPH Oxidases; Propionates; Reactive Oxygen Species; Receptors, Lysophosphatidic Acid; RNA, Messenger; Time Factors; Up-Regulation

2007
Lysophosphatidylglycerol stimulates chemotactic migration and tube formation in human umbilical vein endothelial cells.
    Biochemical and biophysical research communications, 2007, Nov-23, Volume: 363, Issue:3

    Topics: Cell Line; Cell Movement; Chemotaxis; Dose-Response Relationship, Drug; Endothelial Cells; Enzyme Activation; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Humans; Immunoblotting; Isoxazoles; Lysophospholipids; Neovascularization, Physiologic; Pertussis Toxin; Propionates; Receptors, Lysophosphatidic Acid; Umbilical Veins

2007
The orphan GPCR GPR87 was deorphanized and shown to be a lysophosphatidic acid receptor.
    Biochemical and biophysical research communications, 2007, Nov-23, Volume: 363, Issue:3

    Topics: Animals; Binding Sites; Calcium; CHO Cells; Cricetinae; Cricetulus; Electrophoresis, Polyacrylamide Gel; Female; Gene Expression Profiling; GTP-Binding Protein alpha Subunits; Humans; Intracellular Fluid; Isoxazoles; Lysophospholipids; Male; Mice; Mice, Inbred BALB C; Models, Molecular; Propionates; Protein Structure, Tertiary; Receptors, G-Protein-Coupled; Receptors, Lysophosphatidic Acid; Recombinant Fusion Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Uridine Triphosphate

2007
Lysophosphatidic acid-stimulated interleukin-6 and -8 synthesis through LPA1 receptors on human osteoblasts.
    Archives of oral biology, 2008, Volume: 53, Issue:3

    Topics: Boron Compounds; Calcium; Dose-Response Relationship, Drug; Estrenes; Gene Expression; Humans; Inositol 1,4,5-Trisphosphate Receptors; Interleukin-6; Interleukin-8; Isoxazoles; Lysophospholipids; Osteoblasts; Propionates; Pyrrolidinones; Receptors, Lysophosphatidic Acid; RNA, Messenger; Signal Transduction; Stimulation, Chemical; Tumor Cells, Cultured; Type C Phospholipases

2008
Lysophosphatidic acid regulates blood glucose by stimulating myotube and adipocyte glucose uptake.
    Journal of molecular medicine (Berlin, Germany), 2008, Volume: 86, Issue:2

    Topics: 3T3-L1 Cells; Adipocytes; Animals; Blood Glucose; Cell Membrane; Chromones; Diabetes Mellitus, Experimental; Down-Regulation; Glucose; Glucose Transporter Type 4; GTP-Binding Protein alpha Subunits, Gi-Go; Insulin; Isoxazoles; Lysophospholipids; Male; Mice; Mice, Inbred ICR; Morpholines; Muscle Fibers, Skeletal; Pertussis Toxin; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Propionates; Protein Kinase Inhibitors; Protein Transport; Proto-Oncogene Proteins c-akt; Receptors, Lysophosphatidic Acid

2008
LPA1 receptor activation promotes renal interstitial fibrosis.
    Journal of the American Society of Nephrology : JASN, 2007, Volume: 18, Issue:12

    Topics: Animals; Culture Media, Conditioned; Fibrosis; Humans; Isoxazoles; Kidney; Kidney Diseases; Lysophospholipids; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Phospholipids; Propionates; Receptors, Lysophosphatidic Acid; Transforming Growth Factor beta; Ureter

2007
Lysophosphatidic acid protects cancer cells from histone deacetylase (HDAC) inhibitor-induced apoptosis through activation of HDAC.
    The Journal of biological chemistry, 2008, Jun-13, Volume: 283, Issue:24

    Topics: Apoptosis; Catalysis; Cell Membrane; Histone Deacetylase 2; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Humans; Isoxazoles; Lymphocytes; Lysophospholipids; Models, Biological; Neoplasms; Permeability; Promoter Regions, Genetic; Propionates; Repressor Proteins

2008
Lysophosphatidylserine induces calcium signaling through Ki16425/VPC32183-sensitive GPCR in bone marrow-derived mast cells and in C6 glioma and colon cancer cells.
    Archives of pharmacal research, 2008, Volume: 31, Issue:3

    Topics: Animals; Bone Marrow Cells; Calcium Signaling; Colonic Neoplasms; Dose-Response Relationship, Drug; Enzyme Inhibitors; Estrenes; Glioma; HCT116 Cells; Humans; Inositol 1,4,5-Trisphosphate Receptors; Isoxazoles; Lysophospholipids; Male; Mast Cells; Mice; Mice, Inbred BALB C; Organophosphates; Pertussis Toxin; Propionates; Pyridines; Pyrrolidinones; Rats; Receptors, Lysophosphatidic Acid; Time Factors; Type C Phospholipases

2008
Identification of non-lipid LPA3 antagonists by virtual screening.
    Bioorganic & medicinal chemistry, 2008, Jun-01, Volume: 16, Issue:11

    Topics: Animals; Calcium; Calcium Signaling; Cattle; Cell Line, Tumor; CHO Cells; Computer Simulation; Cricetinae; Cricetulus; Diglycerides; Isoxazoles; Lysophospholipids; Models, Chemical; Models, Molecular; Propionates; Protein Isoforms; Rats; Receptors, Lysophosphatidic Acid; Rhodopsin; Structural Homology, Protein

2008
Dioleoyl phosphatidic acid induces morphological changes through an endogenous LPA receptor in C6 glioma cells.
    Archives of pharmacal research, 2008, Volume: 31, Issue:5

    Topics: Animals; Cell Line, Tumor; Cell Survival; Cytotoxins; Drug Partial Agonism; Glioma; Isoproterenol; Isoxazoles; Lysophospholipids; Organophosphates; Pertussis Toxin; Phosphatidic Acids; Propionates; Pyridines; Rats; Receptors, Lysophosphatidic Acid

2008
Lysophosphatidic acid stimulates the proliferation and motility of malignant pleural mesothelioma cells through lysophosphatidic acid receptors, LPA1 and LPA2.
    Cancer science, 2008, Volume: 99, Issue:8

    Topics: Cell Line, Tumor; Cell Movement; Cell Proliferation; Dose-Response Relationship, Drug; Gene Expression; Gene Expression Regulation, Neoplastic; Humans; Isoxazoles; Lysophospholipids; Mesothelioma; Pleural Neoplasms; Propionates; Receptors, Lysophosphatidic Acid

2008
Stimulatory role of lysophosphatidic acid in cyclooxygenase-2 induction by synovial fluid of patients with rheumatoid arthritis in fibroblast-like synovial cells.
    Journal of immunology (Baltimore, Md. : 1950), 2008, Oct-01, Volume: 181, Issue:7

    Topics: Adjuvants, Immunologic; Arthritis, Rheumatoid; Cell Line, Tumor; Cyclooxygenase 2; Cytokines; Dinoprostone; Enzyme Induction; Fibroblasts; Humans; Inflammation Mediators; Isoxazoles; Lysophospholipids; Propionates; Receptors, Lysophosphatidic Acid; Synovial Fluid

2008
Lysophosphatic acid modulates prostaglandin secretion in the bovine uterus.
    Reproduction (Cambridge, England), 2009, Volume: 137, Issue:1

    Topics: Animals; Cattle; Corpus Luteum Maintenance; Dinoprostone; Endometrium; Estrous Cycle; Female; Hydroxyprostaglandin Dehydrogenases; Intramolecular Oxidoreductases; Isoxazoles; Lysophospholipids; Pregnancy; Progesterone; Propionates; Prostaglandin-E Synthases; Receptors, Lysophosphatidic Acid; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger

2009
LPA1 receptors mediate stimulation, whereas LPA2 receptors mediate inhibition, of migration of pancreatic cancer cells in response to lysophosphatidic acid and malignant ascites.
    Carcinogenesis, 2009, Volume: 30, Issue:3

    Topics: Ascites; Cell Line, Tumor; Cell Movement; Collagen; Drug Combinations; Epidermal Growth Factor; GTP-Binding Protein alpha Subunits, Gi-Go; Humans; Isoxazoles; Laminin; Lysophospholipids; Neoplasm Invasiveness; Pancreatic Neoplasms; Pertussis Toxin; Propionates; Proteoglycans; Receptors, Lysophosphatidic Acid; rhoA GTP-Binding Protein; RNA, Small Interfering

2009
Lysophosphatidic acid stimulates cell growth by different mechanisms in SKOV-3 and Caov-3 ovarian cancer cells: distinct roles for Gi- and Rho-dependent pathways.
    Pharmacology, 2009, Volume: 83, Issue:6

    Topics: Cell Line, Tumor; Cell Proliferation; Extracellular Signal-Regulated MAP Kinases; Female; GTP-Binding Proteins; Humans; Isoxazoles; Lysophospholipids; Phosphorylation; Propionates; Receptors, Lysophosphatidic Acid; rho-Associated Kinases; Signal Transduction

2009
Lysophosphatidic acid stimulates prostaglandin E2 production in cultured stromal endometrial cells through LPA1 receptor.
    Experimental biology and medicine (Maywood, N.J.), 2009, Volume: 234, Issue:8

    Topics: Animals; Calcium Signaling; Cattle; Cell Survival; Cells, Cultured; Cyclooxygenase 2; Dinoprost; Dinoprostone; Diphosphates; Endometrium; Epithelial Cells; Female; Glycerol; Intracellular Space; Intramolecular Oxidoreductases; Isoxazoles; Lysophospholipids; Propionates; Prostaglandin-E Synthases; Receptors, Lysophosphatidic Acid; RNA, Messenger; Stromal Cells

2009
Lysophosphatidic Acid signals through specific lysophosphatidic Acid receptor subtypes to control key regenerative responses of human gingival and periodontal ligament fibroblasts.
    Journal of periodontology, 2009, Volume: 80, Issue:8

    Topics: Adult; Blotting, Western; Calcium Signaling; Cells, Cultured; Chemotaxis; Female; Fibroblasts; Fluorescent Dyes; Gingiva; Humans; Isoxazoles; Lysophospholipids; Male; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Organothiophosphates; Periodontal Ligament; Phosphatidic Acids; Phosphorylation; Propionates; Receptors, Lysophosphatidic Acid; Regeneration; Signal Transduction; Wound Healing; Young Adult

2009
Regulation of cerebromicrovascular permeability by lysophosphatidic acid.
    Microcirculation (New York, N.Y. : 1994), 2010, Volume: 17, Issue:1

    Topics: Animals; Calcium Signaling; Capillary Permeability; Cerebrovascular Circulation; Cimetidine; Female; Free Radicals; Histamine H2 Antagonists; Isoxazoles; Lysophospholipids; Male; Microcirculation; Nitric Oxide; Propionates; Rats; Rats, Wistar; Receptors, Lysophosphatidic Acid; Serum Albumin; Signal Transduction; Tachyphylaxis

2010
Diversity of lysophosphatidic acid receptor-mediated intracellular calcium signaling in early cortical neurogenesis.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010, May-26, Volume: 30, Issue:21

    Topics: Animals; Cadmium Chloride; Calcium; Calcium Signaling; Cells, Cultured; Cerebral Cortex; Dose-Response Relationship, Drug; Embryo, Mammalian; Extracellular Fluid; Female; Gene Expression Regulation, Developmental; Glutamic Acid; Intracellular Signaling Peptides and Proteins; Isoxazoles; Lysophospholipids; Membrane Proteins; Mice; Mice, Inbred C57BL; Mice, Knockout; Nerve Tissue Proteins; Neurogenesis; Neurons; Nickel; Organophosphates; Pertussis Toxin; Pituitary Adenylate Cyclase-Activating Polypeptide; Pregnancy; Propionates; Pyridines; RNA, Messenger; Sphingosine; Thapsigargin

2010
TNF-α potentiates lysophosphatidic acid-induced COX-2 expression via PKD in human colonic myofibroblasts.
    American journal of physiology. Gastrointestinal and liver physiology, 2011, Volume: 300, Issue:4

    Topics: Blotting, Western; Cells, Cultured; Colon; Cyclooxygenase 2; Dinoprostone; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Humans; Isoxazoles; Lysophospholipids; Myofibroblasts; Pertussis Toxin; Propionates; Protein Kinase C; Protein Kinase Inhibitors; RNA, Small Interfering; Signal Transduction; Tumor Necrosis Factor-alpha

2011
Lysophosphatidic acid receptor 1 modulates lipopolysaccharide-induced inflammation in alveolar epithelial cells and murine lungs.
    American journal of physiology. Lung cellular and molecular physiology, 2011, Volume: 301, Issue:4

    Topics: Animals; Bronchi; Bronchoalveolar Lavage Fluid; Cells, Cultured; Epithelial Cells; Gene Expression Regulation; Inflammation; Interleukin-6; Interleukin-8; Isoxazoles; Lipopolysaccharide Receptors; Lipopolysaccharides; Lysophospholipids; Male; Membrane Microdomains; Mice; Mice, Knockout; NF-kappa B; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Propionates; Pulmonary Alveoli; Receptor Cross-Talk; Receptors, Lysophosphatidic Acid; Signal Transduction

2011
Lysophosphatidic acid induces erythropoiesis through activating lysophosphatidic acid receptor 3.
    Stem cells (Dayton, Ohio), 2011, Volume: 29, Issue:11

    Topics: AC133 Antigen; Animals; Antigens, CD; Cells, Cultured; Embryo, Nonmammalian; Erythropoiesis; Flow Cytometry; Glycoproteins; Hematopoietic Stem Cells; Humans; Isoxazoles; Lysophospholipids; Peptides; Propionates; Receptors, Lysophosphatidic Acid; Zebrafish

2011
Orally active lysophosphatidic acid receptor antagonist attenuates pancreatic cancer invasion and metastasis in vivo.
    Cancer science, 2012, Volume: 103, Issue:6

    Topics: Animals; Ascites; Cell Line, Tumor; Cell Movement; Humans; Isoxazoles; Lysophospholipids; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Matrix Metalloproteinase Inhibitors; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Invasiveness; Neoplasm Metastasis; Pancreatic Neoplasms; Peritoneal Neoplasms; Propionates; Receptors, Lysophosphatidic Acid; Xenograft Model Antitumor Assays

2012
Effects of lysophosphatidic acid on calpain-mediated proteolysis of focal adhesion kinase in human prostate cancer cells.
    The Prostate, 2012, Volume: 72, Issue:15

    Topics: Adenocarcinoma; Animals; Calpain; Cell Adhesion; Cell Line, Tumor; Cell Movement; Cell Survival; Drug Screening Assays, Antitumor; Fibroblasts; Focal Adhesion Protein-Tyrosine Kinases; Humans; Ionomycin; Isoxazoles; Lysophospholipids; Male; Paxillin; Phosphorylation; Propionates; Prostatic Neoplasms; Proteolysis; Rats; Thapsigargin

2012
Autotaxin/Lpar3 signaling regulates Kupffer's vesicle formation and left-right asymmetry in zebrafish.
    Development (Cambridge, England), 2012, Dec-01, Volume: 139, Issue:23

    Topics: Animals; beta Catenin; Body Patterning; Calcium Signaling; Cell Nucleus; Gene Expression Regulation, Developmental; Gene Knockdown Techniques; Isoxazoles; Lysophospholipids; Morphogenesis; Morpholinos; Phosphoric Diester Hydrolases; Propionates; Receptors, Lysophosphatidic Acid; Receptors, Purinergic P2; Wnt Signaling Pathway; Zebrafish; Zebrafish Proteins

2012
LPA1-induced cytoskeleton reorganization drives fibrosis through CTGF-dependent fibroblast proliferation.
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2013, Volume: 27, Issue:5

    Topics: Anilides; Animals; Benzamides; Biphenyl Compounds; Cell Proliferation; Chlorhexidine; Connective Tissue Growth Factor; Cytoskeleton; Disease Models, Animal; Epithelial Cells; Epithelium; Isoxazoles; Lysophospholipids; Mice; Mice, Inbred C57BL; Mice, Knockout; Myofibroblasts; Peritoneal Fibrosis; Receptors, Lysophosphatidic Acid; Trans-Activators; Transcription Factors

2013
Lysophosphatidic acid impairs glucose homeostasis and inhibits insulin secretion in high-fat diet obese mice.
    Diabetologia, 2013, Volume: 56, Issue:6

    Topics: Adipocytes; Animals; Body Weight; Diet, High-Fat; Gene Expression Regulation; Glucose; Glycogen; Homeostasis; Insulin; Insulin Secretion; Isoxazoles; Lipids; Lysophospholipids; Male; Mice; Mice, Inbred C57BL; Mice, Obese; Muscle, Skeletal; Oxygen; Propionates; Time Factors

2013
Lysophosphatidic acid promotes secretion of VEGF by increasing expression of 150-kD Oxygen-regulated protein (ORP150) in mesenchymal stem cells.
    Biochimica et biophysica acta, 2013, Volume: 1831, Issue:8

    Topics: Adenosine Triphosphate; Animals; Fibroblasts; HSP70 Heat-Shock Proteins; Isoxazoles; Lysophospholipids; Mesenchymal Stem Cells; Myocytes, Cardiac; Organ Specificity; Potassium Channels; Propionates; Proteins; Rats; Rats, Sprague-Dawley; Receptors, Lysophosphatidic Acid; Sodium-Potassium-Exchanging ATPase; Up-Regulation; Vascular Endothelial Growth Factor A

2013
Fear extinction and acute stress reactivity reveal a role of LPA(1) receptor in regulating emotional-like behaviors.
    Brain structure & function, 2014, Volume: 219, Issue:5

    Topics: Amygdala; Animals; Conditioning, Classical; Corticosterone; Cues; Disease Models, Animal; Emotions; Extinction, Psychological; Fear; Gene Expression Regulation; Isoxazoles; Lysophospholipids; Male; Mice; Mice, Knockout; Neurons; Phosphopyruvate Hydratase; Propionates; Receptors, Lysophosphatidic Acid; Stress, Psychological; Time Factors

2014
Lysophosphatidylethanolamine utilizes LPA(1) and CD97 in MDA-MB-231 breast cancer cells.
    Cellular signalling, 2013, Volume: 25, Issue:11

    Topics: Antigens, CD; Boron Compounds; Calcium; Cell Line, Tumor; Female; Gene Expression Regulation, Neoplastic; GTP-Binding Protein alpha Subunits, Gi-Go; Humans; Inositol 1,4,5-Trisphosphate Receptors; Isoxazoles; Lysophospholipids; Organ Specificity; Organophosphates; Pertussis Toxin; Propionates; Pyridines; Receptors, G-Protein-Coupled; Receptors, Lysophosphatidic Acid; RNA, Small Interfering; Signal Transduction; Type C Phospholipases

2013
TAZ mediates lysophosphatidic acid-induced migration and proliferation of epithelial ovarian cancer cells.
    Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2013, Volume: 32, Issue:2

    Topics: Butadienes; Carcinoma, Ovarian Epithelial; Cell Line, Tumor; Cell Movement; Cell Proliferation; Cells, Cultured; Enzyme Inhibitors; Female; Gene Expression Regulation, Neoplastic; Humans; Intracellular Signaling Peptides and Proteins; Isoxazoles; Lysophospholipids; Neoplasms, Glandular and Epithelial; Nitriles; Ovarian Neoplasms; Propionates; Protein Stability; Trans-Activators; Transcription Factors; Transcriptional Coactivator with PDZ-Binding Motif Proteins

2013
Lysophosphatidic acid accelerates lung fibrosis by inducing differentiation of mesenchymal stem cells into myofibroblasts.
    Journal of cellular and molecular medicine, 2014, Volume: 18, Issue:1

    Topics: Animals; Bleomycin; Cell Differentiation; Cells, Cultured; Humans; Isoxazoles; Lysophospholipids; Mesenchymal Stem Cells; Mice; Mice, Inbred ICR; Mice, SCID; Mice, Transgenic; Myofibroblasts; Propionates; Pulmonary Fibrosis; Receptors, Lysophosphatidic Acid; Signal Transduction

2014
Overexpression of autotaxin, a lysophosphatidic acid-producing enzyme, enhances cardia bifida induced by hypo-sphingosine-1-phosphate signaling in zebrafish embryo.
    Journal of biochemistry, 2014, Volume: 155, Issue:4

    Topics: Animals; Down-Regulation; Embryo, Nonmammalian; Heart Defects, Congenital; HEK293 Cells; Humans; Isoxazoles; Lysophospholipids; Phenotype; Phosphoric Diester Hydrolases; Propionates; Receptors, Lysophosphatidic Acid; RNA, Messenger; Signal Transduction; Sphingosine; Zebrafish

2014
Identification of heparin-binding EGF-like growth factor (HB-EGF) as a biomarker for lysophosphatidic acid receptor type 1 (LPA1) activation in human breast and prostate cancers.
    PloS one, 2014, Volume: 9, Issue:5

    Topics: Animals; Biomarkers, Tumor; Breast Neoplasms; Cell Line, Tumor; Female; Gene Expression Regulation, Neoplastic; Heparin-binding EGF-like Growth Factor; Humans; Isoxazoles; Lysophospholipids; Male; Mice; Mice, Inbred BALB C; Mice, Nude; Propionates; Prostatic Neoplasms; Receptors, Lysophosphatidic Acid; RNA, Messenger; Signal Transduction; Xenograft Model Antitumor Assays

2014
Autotaxin produced by stromal cells promotes LFA-1-independent and Rho-dependent interstitial T cell motility in the lymph node paracortex.
    Journal of immunology (Baltimore, Md. : 1950), 2014, Jul-15, Volume: 193, Issue:2

    Topics: Anilides; Animals; Cell Movement; Cells, Cultured; Chemokine CCL21; Female; Isoxazoles; Lymph Nodes; Lymphocyte Function-Associated Antigen-1; Lysophospholipids; Mice; Mice, Inbred C57BL; Microscopy, Fluorescence, Multiphoton; Myosin Type II; Oligonucleotide Array Sequence Analysis; Organophosphonates; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Propionates; Receptors, Lysophosphatidic Acid; Reverse Transcriptase Polymerase Chain Reaction; rho-Associated Kinases; rhoA GTP-Binding Protein; Signal Transduction; Stromal Cells; T-Lymphocytes; Transcriptome

2014
Effect of lysophosphatidic acid receptor inhibition on bone changes in ovariectomized mice.
    Journal of bone and mineral metabolism, 2015, Volume: 33, Issue:4

    Topics: Animals; Bone and Bones; Bone Remodeling; Bone Resorption; Calcification, Physiologic; Cell Differentiation; Disease Models, Animal; Female; Femur; Humans; Immunoenzyme Techniques; Isoxazoles; Lysophospholipids; Mice; Mice, Inbred C57BL; Osteoblasts; Osteoclasts; Osteoporosis; Osteoporosis, Postmenopausal; Ovariectomy; Propionates; Receptors, Lysophosphatidic Acid; Signal Transduction; X-Ray Microtomography

2015
Bioactive lipids, LPC and LPA, are novel prometastatic factors and their tissue levels increase in response to radio/chemotherapy.
    Molecular cancer research : MCR, 2014, Volume: 12, Issue:11

    Topics: Animals; Bone Marrow; Cell Adhesion; Cell Line, Tumor; Cell Movement; Cell Survival; Chemotactic Factors; Drug Resistance, Neoplasm; Gamma Rays; Humans; Isoxazoles; Lysophosphatidylcholines; Lysophospholipids; MAP Kinase Signaling System; Mice, Inbred C57BL; Mice, SCID; Neoplasm Metastasis; Propionates; Receptors, G-Protein-Coupled; Rhabdomyosarcoma; Tumor Microenvironment; Vincristine

2014
Activation of fibroblast-like synoviocytes derived from rheumatoid arthritis via lysophosphatidic acid-lysophosphatidic acid receptor 1 cascade.
    Arthritis research & therapy, 2014, Oct-02, Volume: 16, Issue:5

    Topics: Aged; Aged, 80 and over; Animals; Arthritis, Rheumatoid; Cell Movement; Cell Proliferation; Cells, Cultured; CHO Cells; Cricetinae; Cricetulus; Cytokines; Enzyme-Linked Immunosorbent Assay; Fibroblasts; Gene Expression; Humans; Inflammation Mediators; Isoxazoles; Leukocytes; Lysophospholipids; Middle Aged; Propionates; Receptors, Lysophosphatidic Acid; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Synovial Membrane

2014
Lysophosphatidic acid activates Arf6 to promote the mesenchymal malignancy of renal cancer.
    Nature communications, 2016, Feb-08, Volume: 7

    Topics: ADP-Ribosylation Factor 6; ADP-Ribosylation Factors; Adult; Aged; Aged, 80 and over; Amides; Animals; Antineoplastic Agents; Carcinoma, Renal Cell; Cell Line, Tumor; Cell Survival; Drug Resistance, Neoplasm; Enzyme Inhibitors; Epithelial-Mesenchymal Transition; Female; GTP-Binding Protein alpha Subunits, G12-G13; Guanine Nucleotide Exchange Factors; HEK293 Cells; Humans; Immunohistochemistry; Indoles; Isoxazoles; Kidney Neoplasms; Lysophospholipids; Male; Mice, Nude; Middle Aged; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasm Transplantation; Nerve Tissue Proteins; Propionates; Pyridines; Pyrroles; Receptors, Lysophosphatidic Acid; Signal Transduction; Sirolimus; Sunitinib; Triazoles

2016
Modulation of Nav1.8 by Lysophosphatidic Acid in the Induction of Bone Cancer Pain.
    Neuroscience bulletin, 2016, Volume: 32, Issue:5

    Topics: Animals; Biophysics; Bone Neoplasms; Cancer Pain; Carcinoma; Disease Models, Animal; Electric Stimulation; Enzyme Inhibitors; Female; Ganglia, Spinal; Gene Expression Regulation, Neoplastic; Hyperalgesia; Isoxazoles; Lysophospholipids; Membrane Potentials; NAV1.8 Voltage-Gated Sodium Channel; Neurons; Pain Measurement; Patch-Clamp Techniques; Propionates; Rats; Rats, Sprague-Dawley; Receptors, Lysophosphatidic Acid

2016
Lysophosphatidic acid provides a missing link between osteoarthritis and joint neuropathic pain.
    Osteoarthritis and cartilage, 2017, Volume: 25, Issue:6

    Topics: Activating Transcription Factor 3; Adult; Aged; Aged, 80 and over; Animals; Arthralgia; Arthritis, Experimental; Behavior, Animal; Case-Control Studies; Chromatography, Liquid; Enzyme Inhibitors; Female; Humans; Injections, Intra-Articular; Iodoacetic Acid; Isoxazoles; Lysophospholipids; Male; Middle Aged; Neural Conduction; Neuralgia; Osteoarthritis; Osteoarthritis, Knee; Peripheral Nerves; Propionates; Rats, Inbred Lew; Synovial Fluid

2017
Inhibition of lysophosphatidic acid receptors 1 and 3 attenuates atherosclerosis development in LDL-receptor deficient mice.
    Scientific reports, 2016, 11-24, Volume: 6

    Topics: Animals; Atherosclerosis; Cholesterol, LDL; Disease Models, Animal; Endocytosis; Humans; Isoxazoles; Lysophospholipids; Mice; Propionates; Receptors, LDL; Receptors, Lysophosphatidic Acid; Signal Transduction

2016
Blocking lysophosphatidic acid receptor 1 signaling inhibits diabetic nephropathy in db/db mice.
    Kidney international, 2017, Volume: 91, Issue:6

    Topics: Animals; Cell Line; Diabetes Mellitus; Diabetic Nephropathies; Disease Models, Animal; Disease Progression; Glycogen Synthase Kinase 3 beta; Isoxazoles; Kidney Cortex; Lysophospholipids; Male; Mice, Inbred C57BL; Phosphoric Diester Hydrolases; Phosphorylation; Propionates; Receptors, Lysophosphatidic Acid; RNA Interference; Signal Transduction; Smad2 Protein; Smad3 Protein; Sterol Regulatory Element Binding Protein 1; Time Factors; Transfection; Transforming Growth Factor beta

2017
CD14 is a key mediator of both lysophosphatidic acid and lipopolysaccharide induction of foam cell formation.
    The Journal of biological chemistry, 2017, 09-01, Volume: 292, Issue:35

    Topics: Absorption, Physiological; Animals; Biomarkers; Bone Marrow Cells; Cells, Cultured; Foam Cells; Gene Expression Regulation; Humans; Isoxazoles; Lipopolysaccharide Receptors; Lipopolysaccharides; Lipoproteins, LDL; Lysophospholipids; Macrophages; Mice, Inbred C57BL; Mice, Knockout; Microscopy, Fluorescence; Propionates; Receptors, Lysophosphatidic Acid; RNA Interference; Scavenger Receptors, Class A

2017
Blocking gp130 signaling suppresses autotaxin expression in adipocytes and improves insulin sensitivity in diet-induced obesity.
    Journal of lipid research, 2017, Volume: 58, Issue:11

    Topics: 3T3-L1 Cells; Adipocytes; Animals; Cytokine Receptor gp130; Diet; Down-Regulation; Fatty Acids, Nonesterified; Glucose; Hydrazines; Insulin Resistance; Interleukin-6; Isoxazoles; Janus Kinases; Lipolysis; Lysophospholipids; Mice; Obesity; Phosphoric Diester Hydrolases; Propionates; Quinoxalines; Signal Transduction; STAT3 Transcription Factor

2017
Lysophosphatidic acid protects against acetaminophen-induced acute liver injury.
    Experimental & molecular medicine, 2017, 12-08, Volume: 49, Issue:12

    Topics: Acetaminophen; Animals; Apoptosis; Chemical and Drug Induced Liver Injury; Gene Expression Regulation; Hepatocytes; Humans; Interleukin-1beta; Isoxazoles; Liver; Lysophospholipids; Mice; Oxidative Stress; Propionates; Receptors, Lysophosphatidic Acid; Tumor Necrosis Factor-alpha

2017
Lysophosphatidic Acid Induces Ligamentum Flavum Hypertrophy Through the LPAR1/Akt Pathway.
    Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2018, Volume: 45, Issue:4

    Topics: Animals; Apoptosis; Cell Proliferation; Cell Survival; Cells, Cultured; Cyclin-Dependent Kinases; G2 Phase Cell Cycle Checkpoints; Humans; Hypertrophy; Isoxazoles; Ligamentum Flavum; Lumbar Vertebrae; Lysophospholipids; Male; Phosphorylation; Propionates; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Receptors, Lysophosphatidic Acid; RNA Interference; Signal Transduction

2018
Pharmacologic targeting of the ATX/LPA axis attenuates bleomycin-induced pulmonary fibrosis.
    Pulmonary pharmacology & therapeutics, 2018, Volume: 52

    Topics: Animals; Benzoxazoles; Biphenyl Compounds; Bleomycin; Idiopathic Pulmonary Fibrosis; Isoxazoles; Kaplan-Meier Estimate; Lung; Lysophospholipids; Male; Mice; Mice, Inbred C57BL; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Piperazines; Random Allocation

2018
Lysophosphatidic acid triggers cathepsin B-mediated invasiveness of human endometriotic cells.
    Biochimica et biophysica acta. Molecular and cell biology of lipids, 2018, Volume: 1863, Issue:11

    Topics: Cathepsin B; Cell Line; Cell Movement; Cell Proliferation; Dose-Response Relationship, Drug; Endometriosis; Female; Humans; Isoxazoles; Lysophospholipids; Propionates; Receptors, Lysophosphatidic Acid; Time Factors; Up-Regulation

2018
LPA
    Science advances, 2019, Volume: 5, Issue:10

    Topics: Animals; Animals, Newborn; Apoptosis; Brain; Calcium-Binding Proteins; Disease Models, Animal; Ependyma; Ependymoglial Cells; Infant, Premature, Diseases; Isoxazoles; Lysophospholipids; Macrophages; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Microfilament Proteins; Phagocytosis; Propionates; Receptors, Lysophosphatidic Acid

2019
LPA receptor1 antagonists as anticancer agents suppress human lung tumours.
    European journal of pharmacology, 2020, Feb-05, Volume: 868

    Topics: A549 Cells; Animals; Antineoplastic Agents; Cell Movement; Gene Knockdown Techniques; GTP-Binding Protein alpha Subunits, Gi-Go; Humans; Isoxazoles; Lung Neoplasms; Lysophospholipids; Male; MAP Kinase Signaling System; Mice; NF-kappa B; Propionates; Receptors, Lysophosphatidic Acid; Xenograft Model Antitumor Assays

2020
Lysophosphatidic Acid Inhibits Simvastatin-Induced Myocytoxicity by Activating LPA Receptor/PKC Pathway.
    Molecules (Basel, Switzerland), 2020, Mar-27, Volume: 25, Issue:7

    Topics: Animals; Apoptosis; bcl-2-Associated X Protein; Calcium; Caspase 3; Cell Line; Cell Survival; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Indoles; Isoxazoles; Lysophospholipids; Maleimides; Myoblasts; Propionates; Protein Kinase C; Rats; Receptors, Lysophosphatidic Acid; Signal Transduction; Simvastatin

2020
Increased Levels of Renal Lysophosphatidic Acid in Rodent Models with Renal Disease.
    The Journal of pharmacology and experimental therapeutics, 2021, Volume: 376, Issue:2

    Topics: Animals; Diabetic Nephropathies; Fibrosis; Hypertension, Renal; Isoxazoles; Kidney; Lysophospholipids; Male; Propionates; Rats; Rats, Inbred Dahl; Rats, Sprague-Dawley

2021
Crystalline silica particles induce DNA damage in respiratory epithelium by ATX secretion and Rac1 activation.
    Biochemical and biophysical research communications, 2021, 04-09, Volume: 548

    Topics: Animals; Crystallization; DNA Breaks, Double-Stranded; DNA Damage; Enzyme Activation; Enzyme Inhibitors; Humans; Isoxazoles; Lysophospholipids; Male; Membrane Potential, Mitochondrial; Mice, Inbred C57BL; Phosphoric Diester Hydrolases; Propionates; rac1 GTP-Binding Protein; Receptors, Lysophosphatidic Acid; Respiratory Mucosa; Silicon Dioxide; Tumor Suppressor p53-Binding Protein 1

2021
Lysophosphatidic Acid Promotes Epithelial-Mesenchymal Transition in Kidney Epithelial Cells via the LPAR1/MAPK-AKT/KLF5 Signaling Pathway in Diabetic Nephropathy.
    International journal of molecular sciences, 2022, Sep-10, Volume: 23, Issue:18

    Topics: Actins; Animals; Cadherins; Diabetic Nephropathies; Epithelial Cells; Epithelial-Mesenchymal Transition; Extracellular Signal-Regulated MAP Kinases; Factor V; Fibronectins; Fibrosis; Glycerophospholipids; Isoxazoles; JNK Mitogen-Activated Protein Kinases; Kidney Tubules; Kruppel-Like Transcription Factors; Lysophospholipids; Mice; Propionates; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins c-akt; Signal Transduction; Transcription Factors; Vimentin

2022