lysine has been researched along with wortmannin in 12 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (16.67) | 18.2507 |
| 2000's | 9 (75.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (8.33) | 2.80 |
| Authors | Studies |
|---|---|
| Bulgarelli-Leva, G; Panayotou, G; Pirola, L; Vanhaesebroeck, B; Waterfield, MD; Wymann, MP; Zvelebil, MJ | 1 |
| Bulgarelli-Leva, G; Hanck, T; Kirsch, C; Klinger, R; Stoyanova, S; Wetzker, R; Wymann, MP | 1 |
| Bargonetti, J; Chicas, A; Kramer, FR; Olivier, M; Taya, Y; Tyagi, S; Xiao, G | 1 |
| Berg, LJ; Ching, KA; Tsoukas, CD; Yang, WC | 1 |
| Boehr, DD; Lane, WS; Wright, GD | 1 |
| Ikonomov, OC; Sbrissa, D; Shisheva, A | 1 |
| Hashimoto, M; Holman, GD; Potter, BV; Reaves, BJ; Riley, AM; Whitley, P | 1 |
| Horio, Y; Osada, H; Sugito, N; Takahashi, T; Tatematsu, Y | 1 |
| Dai, W; Jiang, N; Liu, Y; Rosenblum, JS; Wu, J | 1 |
| Ase, AR; Bernier, LP; Blais, D; Hamel, E; Logothetis, DE; Séguéla, P; Tong, X; Zhao, Q | 1 |
| Bahia, D; Lima, FM; Mortara, RA; Oliveira, LM; Oliveira, P; Ruiz, JC; Silveira, JF | 1 |
| Chen, D; He, Q; He, X; Li, J; Li, M; Li, T; Liu, H; Liu, J; Tao, Y; Zang, S; Zhang, L | 1 |
12 other study(ies) available for lysine and wortmannin
| Article | Year |
|---|---|
Wortmannin inactivates phosphoinositide 3-kinase by covalent modification of Lys-802, a residue involved in the phosphate transfer reaction.
Topics: Adenosine Triphosphate; Amino Acid Sequence; Androstadienes; Enzyme Inhibitors; Kinetics; Lysine; Models, Molecular; Molecular Sequence Data; Phosphatidylinositol 3-Kinases; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositol Phosphates; Phosphotransferases (Alcohol Group Acceptor); Point Mutation; Signal Transduction; Substrate Specificity; Wortmannin | 1996 |
Lipid kinase and protein kinase activities of G-protein-coupled phosphoinositide 3-kinase gamma: structure-activity analysis and interactions with wortmannin.
Topics: Adenosine Triphosphate; Androstadienes; Animals; Binding Sites; Catalysis; Cell Line; Cloning, Molecular; Enzyme Inhibitors; GTP-Binding Proteins; Humans; Lysine; Mutagenesis, Site-Directed; Nucleopolyhedroviruses; Phosphatidylinositol 3-Kinases; Phosphatidylinositols; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Protein Processing, Post-Translational; Recombinant Fusion Proteins; Signal Transduction; Spodoptera; Structure-Activity Relationship; Substrate Specificity; Wortmannin | 1997 |
A DNA damage signal is required for p53 to activate gadd45.
Topics: Acetylation; Androstadienes; Camptothecin; Cell Line; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Deoxyribonuclease I; DNA; DNA Damage; GADD45 Proteins; Gene Expression Regulation; Humans; Intracellular Signaling Peptides and Proteins; Lysine; Nuclear Proteins; Phosphorylation; Promoter Regions, Genetic; Protein Binding; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-mdm2; Serine; Signal Transduction; Transcription, Genetic; Tumor Suppressor Protein p53; Wortmannin | 2000 |
Tec kinase signaling in T cells is regulated by phosphatidylinositol 3-kinase and the Tec pleckstrin homology domain.
Topics: Amino Acid Substitution; Androstadienes; Animals; Arginine; Blood Proteins; Cysteine; Enzyme Inhibitors; Glutamic Acid; Humans; Interleukin-2; Jurkat Cells; Lysine; Mice; Mice, Transgenic; Phosphatidylinositol 3-Kinases; Phosphatidylinositol Phosphates; Phosphoinositide-3 Kinase Inhibitors; Phosphoproteins; Phosphorylation; Phosphotyrosine; Protein Binding; Protein Structure, Tertiary; Protein-Tyrosine Kinases; Receptor-CD3 Complex, Antigen, T-Cell; Receptors, Antigen, T-Cell; Sequence Homology, Amino Acid; Signal Transduction; T-Lymphocytes; Transfection; Wortmannin | 2001 |
Active site labeling of the gentamicin resistance enzyme AAC(6')-APH(2") by the lipid kinase inhibitor wortmannin.
Topics: Acetyltransferases; Adenosine Triphosphate; Amino Acid Sequence; Androstadienes; Binding Sites; Dose-Response Relationship, Drug; Drug Design; Drug Resistance, Bacterial; Enzyme Inhibitors; Escherichia coli; Gentamicins; Kanamycin Kinase; Kinetics; Lysine; Molecular Sequence Data; Mutagenesis, Site-Directed; Phosphoinositide-3 Kinase Inhibitors; Phosphotransferases (Alcohol Group Acceptor); Protein Structure, Tertiary; Recombinant Fusion Proteins; Sequence Homology, Amino Acid; Wortmannin | 2001 |
Phosphatidylinositol 3-phosphate-interacting domains in PIKfyve. Binding specificity and role in PIKfyve. Endomenbrane localization.
Topics: Amino Acid Sequence; Androstadienes; Animals; Binding Sites; Chlorocebus aethiops; Cloning, Molecular; COS Cells; Enzyme Inhibitors; Escherichia coli; Intracellular Membranes; Kinetics; Liposomes; Lysine; Peptide Fragments; Phosphatidylinositol 3-Kinases; Recombinant Fusion Proteins; Recombinant Proteins; Transfection; Vacuoles; Wortmannin | 2002 |
Identification of mammalian Vps24p as an effector of phosphatidylinositol 3,5-bisphosphate-dependent endosome compartmentalization.
Topics: Adenosine Triphosphate; Adipocytes; Adipose Tissue; Amino Acid Sequence; Androstadienes; Animals; Base Sequence; Binding, Competitive; Biotinylation; Carrier Proteins; Cell Membrane; Cells, Cultured; COS Cells; Cytosol; DNA; DNA, Complementary; Endosomal Sorting Complexes Required for Transport; Endosomes; Enzyme Inhibitors; Escherichia coli; Green Fluorescent Proteins; Hydrolysis; Lipid Metabolism; Liposomes; Luminescent Proteins; Lysine; Male; Microscopy, Fluorescence; Models, Chemical; Molecular Sequence Data; Mutation; Open Reading Frames; Peptide Library; Phenotype; Phosphatidylinositol Phosphates; Protein Binding; Protein Structure, Tertiary; Rats; Rats, Wistar; Recombinant Proteins; Saccharomyces cerevisiae; Sequence Homology, Amino Acid; Transfection; Vesicular Transport Proteins; Wortmannin | 2003 |
Histone modification in the TGFbetaRII gene promoter and its significance for responsiveness to HDAC inhibitor in lung cancer cell lines.
Topics: Acetylation; Androstadienes; Azacitidine; Chromatin; DNA Methylation; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Gene Silencing; Histone Deacetylase Inhibitors; Histones; Humans; Hydroxamic Acids; Lung Neoplasms; Lysine; Phosphoinositide-3 Kinase Inhibitors; Promoter Regions, Genetic; Protein Serine-Threonine Kinases; Receptor, Transforming Growth Factor-beta Type II; Receptors, Transforming Growth Factor beta; Signal Transduction; Transcription, Genetic; Tumor Cells, Cultured; Wortmannin | 2005 |
Polo-like kinases inhibited by wortmannin. Labeling site and downstream effects.
Topics: Amino Acid Sequence; Androstadienes; Binding Sites; Cell Line; DNA Damage; Heterocyclic Compounds, 4 or More Rings; Humans; Lysine; Molecular Sequence Data; Phosphorylation; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Rhodamines; Sequence Alignment; Substrate Specificity; Tumor Suppressor Proteins; Wortmannin | 2007 |
Direct modulation of P2X1 receptor-channels by the lipid phosphatidylinositol 4,5-bisphosphate.
Topics: Adenosine Triphosphate; Amino Acid Sequence; Androstadienes; Animals; Electrophysiology; In Vitro Techniques; Ion Channel Gating; Kinetics; Lysine; Mesenteric Arteries; Molecular Sequence Data; Oocytes; Phosphatidylinositol 4,5-Diphosphate; Protein Structure, Tertiary; Protein Subunits; Rats; Receptor, Serotonin, 5-HT2A; Receptors, Purinergic P2; Receptors, Purinergic P2X; Recombinant Proteins; Vasoconstriction; Wortmannin; Xenopus | 2008 |
The TryPIKinome of five human pathogenic trypanosomatids: Trypanosoma brucei, Trypanosoma cruzi, Leishmania major, Leishmania braziliensis and Leishmania infantum--new tools for designing specific inhibitors.
Topics: 1-Phosphatidylinositol 4-Kinase; Amino Acid Sequence; Androstadienes; Autophagy; Cell Membrane; Cytokinesis; Drug Design; Enzyme Inhibitors; Humans; Leishmania braziliensis; Leishmania infantum; Leishmania major; Lysine; Molecular Sequence Data; Phylogeny; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosoma cruzi; Trypanosomatina; Wortmannin | 2009 |
Spatially targeting and regulating tumor-associated macrophages using a raspberry-like micellar system sensitizes pancreatic cancer chemoimmunotherapy.
Topics: Cathepsin B; Cell Line, Tumor; Humans; Lysine; Macrophages; Micelles; Pancreatic Neoplasms; Peptides; Phosphatidylinositol 3-Kinases; Polyethylene Glycols; Tumor Microenvironment; Tumor-Associated Macrophages; Wortmannin | 2022 |