lysine has been researched along with trimethyllysine in 155 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 62 (40.00) | 18.7374 |
| 1990's | 23 (14.84) | 18.2507 |
| 2000's | 24 (15.48) | 29.6817 |
| 2010's | 39 (25.16) | 24.3611 |
| 2020's | 7 (4.52) | 2.80 |
| Authors | Studies |
|---|---|
| Blount, KF; Breaker, RR; Lim, J; Sudarsan, N; Wang, JX | 1 |
| Bhatnagar, PK; Dedman, JR; Jackson, RL; Knapp, RD; Means, AR; Schreiber, WE | 1 |
| Kakiuchi, S; Miyake, M | 1 |
| Carter, AL; Frenkel, R | 1 |
| Lazarides, E; Lin, JM; Wang, C | 1 |
| Bergman, LW; Cessay, KJ; Tuck, MT | 1 |
| Kakimoto, Y; Miyake, M; Mizobuchi, M; Sano, A | 1 |
| Dubois, I; Gerday, C | 1 |
| Davis, AT | 1 |
| Huang, YP; Kimura, M; Tawada, K | 1 |
| Costello, CE; Dever, TE; Merrick, WC; Owens, CL; Rosenberry, TL | 1 |
| Hoppel, CL; Sandor, A | 1 |
| Bosch, EP; Chenard, CA; Nelson, SE; Rebouche, CJ; Schabold, KJ | 1 |
| Broquist, HP | 2 |
| Lukas, TJ; Roberts, DM; Rowe, PM; Siegel, FL; Watterson, DM | 1 |
| Lehman, LJ; Olson, L; Rebouche, CJ | 1 |
| Davis, AT; Hoppel, CL | 3 |
| Rebouche, CJ | 3 |
| Benoiton, NL; Chen, FM | 1 |
| Garcia, R; Hiatt, WR; Jasinski, S; Sypherd, PS | 1 |
| Ikura, M | 1 |
| Hörl, WH; Wanner, C | 1 |
| Adibi, SA; Gleditsch, CE; Paul, HS | 1 |
| Erdos, EA; Griffin, RL; Hoppel, CL; Ingalls, ST; Minkler, PE | 1 |
| Olson, AL; Rebouche, CJ | 1 |
| Lehman, LJ; Olson, AL; Rebouche, CJ | 1 |
| Bamji, MS; Khan-Siddiqui, L; Murthy, SN; Vijayasarathy, C | 1 |
| Franz, HE; Fürst, P; Graser, TA; Kohse, KP | 1 |
| Broquist, HP; Tanphaichitr, V | 1 |
| Evans, CT; Owens, DD; Slaughter, CA; Srere, PA | 1 |
| Franz, HE; Fürst, P; Godel, HG; Graser, TA; Kohse, KP; Rössle, C | 1 |
| Kopper, L; Lapis K Tyihák, E; Szende, B | 1 |
| Bach, A | 1 |
| Hergenhahn, HG; Kegel, G; Sedlmeier, D | 1 |
| Brittain, AT; Brown, FM; Gibbons, AP; Hoppel, CL; Ingalls, ST; Weir, DE | 1 |
| Kovács, L; Lapis, K; Simon, K; Szende, B | 1 |
| Korn, ED; Lal, AA; Vandekerckhove, J | 1 |
| Davis, AT; Hoppel, CL; Ingalls, ST | 1 |
| Dunn, WA; Englard, S; Rettura, G; Seifter, E | 1 |
| Huszar, G | 1 |
| Broquist, HP; Sachan, DS | 1 |
| Elek, G; Lapis, K; Suba, Z; Szende, B; Takács, J | 1 |
| Engel, AG; Rebouche, CJ | 3 |
| Cox, RA; Hoppel, CL; Novak, RF | 1 |
| Hoppel, CL; Novak, RF; Swift, TJ | 1 |
| Hoppel, CL; Sachan, DS | 1 |
| Bursics, L; Gyapay, G; Jeney, A; Lapis, K; Szende, B; Tyihák, E | 1 |
| Conti, P; Elek, G; Lapis, K; Suba, Z; Szende, B; Takacs, J | 1 |
| Dognin, MJ; Wittmann-Liebold, B | 1 |
| Henderson, LL; Henderson, LM; Jenness, R; Nelson, PJ; Pruitt, RE | 1 |
| Friedman, M; Gumbmann, MR | 1 |
| Dunn, WA; Englard, S | 1 |
| Bloxham, DP; Ericsson, LH; Kumar, S; Neurath, H; Parmelee, DC; Titani, K; Wade, RD; Walsh, KA | 1 |
| Englard, S; Stein, R | 2 |
| Borum, PR; Broquist, HP | 1 |
| Aronson, NN; Dunn, WA; Englard, S | 1 |
| Henderson, L; Henderson, LM; Nelson, PJ | 1 |
| Lapis, K; Simon, K; Szende, B | 1 |
| Elek, G; Láng, I; Lapis, K; Szende, B | 1 |
| Bronson, RT; Chin, DT; Gao, CL; Katz, ML; Tompkins, JA | 1 |
| Katz, ML; Siakotos, AN | 1 |
| Decottignies, P; Gadal, P; Jacquot, JP; Le Maréchal, P; Schmitter, JM | 1 |
| Szende, B | 1 |
| Bergman, LW; Ceesay, KJ; Rider, LR; Tuck, MT | 1 |
| Huque, E; Vogel, HJ; Zhang, M | 1 |
| Christianson, JS; Gao, CL; Katz, ML; Koppang, N; Norbury, NE; Siakotos, AN | 1 |
| Bock, I; Melegh, B; Pap, M; Rebouche, CJ | 1 |
| Barker, PD; Eltis, LD; Guillemette, JG; Inglis, SC; Mauk, AG; Miller, CM; Northrup, SH; Thomasson, KA | 1 |
| Cavallius, J; Chakraburtty, K; Merrick, WC; Zoll, W | 1 |
| Davis, AT; Kruggel, EM; Randall, S | 1 |
| Bock, I; Hermann, R; Melegh, B | 1 |
| Katz, ML | 1 |
| Chin, DT; Freiha, B; Gao, Q; Katz, ML; Siakotos, AN | 1 |
| Adamovich, K; Bieber, LL; Gage, DA; Melegh, B; Szekely, G; Tóth, G | 1 |
| Inoue, F; Kinugasa, A; Kizaki, Z; Nakajima, H; Okochi, M; Sawada, T; Terada, N | 1 |
| Bredesen, D; Ellerby, HM; Ellerby, LM; Kluck, RM; Margoliash, E; Mauk, AG; Naiem, S; Newmeyer, DD; Sherman, F; Yaffe, MP | 1 |
| Brass, EP; Hoppel, CL; Krähenbühl, S | 1 |
| Jacobs, SA; Khorasanizadeh, S | 1 |
| Bene, J; Bieber, LL; Bootsma, A; Cuebas, D; Gage, DA; Melegh, B; van Gennip, AH; Vaz, FM; Vreken, P; Wanders, RJ | 1 |
| Hirota, J; Satomi, Y; Takao, T; Yoshikawa, K | 1 |
| Bull, MG; Finn, PJ; Flick, PK; Fuller, CW; Grossmann, G; Kumar, S; Mamone, JA; McArdle, BF; Nampalli, S; Nelson, JR; Phillips, PD; Xiao, H | 1 |
| Bannister, AJ; Crane-Robinson, C; Kouzarides, T; Myers, FA; Schneider, R; Thorne, AW | 1 |
| Davis, AT; Monroe, TJ | 1 |
| Blobel, GA; Mandat, SA; Olenchock, BA; Vakoc, CR | 1 |
| Blackburn, GM; Couture, JF; Hauk, G; Thompson, MJ; Trievel, RC | 1 |
| van Vlies, N; Vaz, FM; Wanders, RJ | 1 |
| Couture, JF; Dietzel, K; Dirk, LM; Flynn, EM; Houtz, RL; Trievel, RC | 1 |
| Hughes, RM; Khorasanizadeh, S; Waters, ML; Wiggins, KR | 1 |
| Brunzelle, JS; Collazo, E; Couture, JF; Ortiz-Tello, PA; Trievel, RC | 1 |
| Eder, K; Hirche, F; Pösel, S; Ringseis, R | 1 |
| Abbruzzese, JL; Adsay, NV; Albarracin, C; Bast, RC; Hortobagyi, GN; Hung, MC; Liu, J; Mills, GB; Wang, H; Wei, Y; Xia, W; Yu, D; Zhang, Z | 1 |
| Eder, K; Koch, A; König, B; Stangl, GI | 1 |
| Gaucher, SP; Keasling, JD; Mukhopadhyay, A; Redding, AM; Singh, AK | 1 |
| Eder, K; Fischer, M; Hirche, F; Kluge, H | 1 |
| Ping, L; Wang, Y; Xiong, L; Yuan, B | 1 |
| Eder, K; Fischer, M; Hirche, F; Keller, J | 1 |
| De Marco, V; Drury, WJ; Gamblin, SJ; Justin, N; Margueron, R; Martin, SR; Ohno, K; Pirrotta, V; Reinberg, D; Sharpe, ML; Son, J; Taylor, WR; Voigt, P | 1 |
| Lai, J; Lu, Z; Zhang, Y | 1 |
| Eder, K; Hanisch, N; Ringseis, R; Seliger, G | 1 |
| Abe, R; Hohsaka, T; Horiike, K; Muranaka, N; Shiraga, K; Tokuda, Y; Watanabe, T | 1 |
| Collazo, E; Krishnan, S; Ortiz-Tello, PA; Trievel, RC | 1 |
| Eisert, RJ; Waters, ML | 1 |
| Kim, S; Kim, YS; Lou, MF; Paik, MK; Paik, WK | 1 |
| Daze, KD; Hof, F; Ma, MC; Pineux, F | 1 |
| Daze, KD; Hof, F | 1 |
| Hof, F; Whiting, AL | 1 |
| Charrier, A; Merlier, F; Perrin, Y; Rippa, S; Zhao, Y | 1 |
| Bowler, BE; Cherney, MM; Junior, CC | 1 |
| Bleie, O; Borgeraas, H; Løland, KH; Nordrehaug, JE; Nygård, O; Strand, E; Svardal, A; Ueland, PM | 1 |
| Dhayalan, A; Jeltsch, A; Kudithipudi, S; Kungulovski, G; Kycia, I; Tamas, R | 1 |
| Belle, R; Mecinović, J; Pieters, B | 1 |
| Balestrieri, ML; Castaldo, D; Cautela, D; Giovane, A; Servillo, L | 1 |
| Abeykoon, A; Chao, CC; Ching, WM; Chock, PB; Gucek, M; Wang, G; Yang, DC | 1 |
| Allen, HF; Daze, KD; Hof, F; Kutateladze, TG; Lai, A; Musselman, CA; Shimbo, T; Sims, JK; Wade, PA | 1 |
| Boulanger, MJ; Daze, KD; Dev, A; Douglas, SF; Gignac, MC; Heller, M; Hof, F; Peng, F; Quon, TT; Simhadri, C; Wulff, JE | 1 |
| Pinkin, NK; Waters, ML | 1 |
| Chen, Z; Grzybowski, AT; Ruthenburg, AJ | 1 |
| Clarke, SG; Dzialo, MC; Loo, JA; Shen, S; Travaglini, KJ | 1 |
| Bandi, S; Bowler, BE; Cherney, MM; Culbertson, JE; Khan, MK; McClelland, LJ; Seagraves, SM | 1 |
| Abron, JD; Liu, I; Pinkin, NK; Waters, ML | 1 |
| Beuming, T; Dong, A; Huang, J; Kamps, JJ; Li, H; Matthias Bickelhaupt, F; Mecinović, J; Min, J; Pieters, BJ; Poater, J; Sherman, W; Xu, C | 1 |
| Bundy, JG; Ebbels, TM; Hao, J; Liebeke, M; Sommer, U; Viant, MR | 1 |
| Abbas, A; Aukrust, P; Berge, RK; Bjerkeli, V; Gregersen, I; Halvorsen, B; Holm, S; Hov, JE; Karlsen, TH; Kummen, M; Reier-Nilsen, F; Russell, D; Skagen, K; Skjelland, M; Svardal, A; Trøseid, M; Ueland, T | 1 |
| Gober, IN; Waters, ML | 1 |
| Leśniak, RK; Markolovic, S; Schofield, CJ; Tars, K | 1 |
| Al Temimi, AH; Mecinović, J; Reddy, YV; White, PB | 1 |
| Al Temimi, AH; Mecinović, J; Vijayendar Reddy, Y | 1 |
| Chen, Z; Notti, RQ; Ruthenburg, AJ; Ueberheide, B | 1 |
| Albanese, KI; Baril, SA; Brustad, EM; He, CQ; Houk, KN; Koenig, AL; Krone, MW; Lee, GY; Waters, ML | 1 |
| Denton, KE; Dykhuizen, EC; Gignac, MC; Hof, F; Krusemark, CJ; Milosevich, N; Wang, S | 1 |
| Berge, RK; Flygel, MR; Lysne, V; Løland, KH; Nygård, O; Pedersen, ER; Rebnord, EW; Strand, E; Svardal, A; Svingen, GFT; Tell, GS | 1 |
| Al Temimi, AHK; Belle, R; Betlem, P; Bickelhaupt, FM; Kumar, K; Mecinović, J; Paton, RS; Pieters, BJGE; Poater, J | 1 |
| Allayee, H; Buffa, JA; Cajka, T; DiDonato, JA; Fiehn, O; Gu, X; Han, Y; Hartiala, JA; Hazen, SL; Hurd, AG; Kerby, RL; Li, L; Li, XS; Lüscher, TF; Nemet, I; Obeid, S; Rey, FE; Roberts, AB; Romano, KA; Shahen, CJ; Skye, SM; Tang, WHW; Wagner, MA; Wang, Z; Wu, Y | 1 |
| Cao, C; Jiang, B; Lan, W; Li, C; Liu, M; Sun, P; Wang, Q; Yuan, B; Zhang, X; Zhu, Q | 1 |
| Al Temimi, AHK; Grobben, Y; Hintzen, JCJ; Kamps, JJAG; Mecinović, J; Pieters, BJGE | 1 |
| Chung, YM; Gu, X; Hazen, BJ; Hazen, SL; Hurd, AG; Levison, BS; Li, L; Li, XS; Lüscher, TF; Mach, F; Matter, CM; Nanchen, D; Nissen, SE; Obeid, S; Pratt, A; Räber, L; Tang, WHW; Wang, Z; Wu, Y | 1 |
| Schiattarella, GG; Trimarco, B | 1 |
| Masuda, S; Tsuda, S; Yoshiya, T | 1 |
| Berge, RK; Bjørnestad, EØ; Dhar, I; Løland, K; Nilsen, DWT; Nordrehaug, JE; Nygaard, E; Nygård, O; Olset, H; Pedersen, EKR; Svardal, A; Svingen, GFT; Tell, GS; Ueland, PM | 1 |
| Al Temimi, AHK; Bickelhaupt, FM; Hintzen, JCJ; Kumar, K; Mecinović, J; Paton, RS; Pieters, BJGE; Poater, J | 1 |
| von Eckardstein, A | 1 |
| Hintzen, JCJ; Maas, MN; Mecinović, J; Porzberg, MRB | 1 |
| Böger, R; Choe, CU; Gerloff, C; Lezius, S; Peine, S; Schwedhelm, E; Thomalla, G; von Lucadou, M | 1 |
| Cheng, A; Cheng, S; Gao, J; Li, H; Meng, X; Wang, A; Wang, Y; Xu, J; Xu, M; Xue, J; Zhan, R; Zhang, Q; Zhao, M; Zheng, L | 1 |
| Gu, S; Liu, D; Ma, Z; Wang, J; Xiao, L; Zhou, Z; Zuo, H | 1 |
3 review(s) available for lysine and trimethyllysine
| Article | Year |
|---|---|
Carnitine biosynthesis in rat and man: tissue specificity.
Topics: Aldehydes; Animals; Betaine; Carnitine; Humans; Hydroxylysine; Lysine; Organ Specificity; Rats; Species Specificity | 1981 |
Carnitine biosynthesis: nutritional implications.
Topics: Adenosine Triphosphate; Adolescent; Adult; Aged; Animals; Carnitine; Child; Child, Preschool; Female; Food Analysis; Humans; Infant; Infant, Newborn; Kidney Diseases; Liver Cirrhosis; Lysine; Methionine; Middle Aged; Milk, Human; Mitogens; Muscles; Muscular Diseases; Pregnancy; Protein Deficiency; Rats | 1982 |
Trimethyllysine: From Carnitine Biosynthesis to Epigenetics.
Topics: Animals; Carnitine; Epigenesis, Genetic; Histone-Lysine N-Methyltransferase; Humans; Lysine; Protein Processing, Post-Translational | 2020 |
1 trial(s) available for lysine and trimethyllysine
| Article | Year |
|---|---|
The association between progression of atherosclerosis and the methylated amino acids asymmetric dimethylarginine and trimethyllysine.
Topics: Adenosine; Aged; Arginine; Coronary Angiography; Coronary Artery Disease; Disease Progression; Ethionine; Female; Folic Acid; Follow-Up Studies; Humans; Lysine; Male; Methylation; Middle Aged; Treatment Outcome; Vitamin B 12; Vitamin B 6; Vitamin B Complex | 2013 |
151 other study(ies) available for lysine and trimethyllysine
| Article | Year |
|---|---|
Antibacterial lysine analogs that target lysine riboswitches.
Topics: Anti-Bacterial Agents; Bacillus subtilis; Bacteria; Gene Expression Regulation, Bacterial; Lysine; Microbial Sensitivity Tests; Molecular Structure; Nucleic Acid Conformation; Regulatory Elements, Transcriptional; RNA, Bacterial | 2007 |
Identification of epsilon-N-trimethyllysine in a rat testis calcium-dependent regulatory protein of cyclic nucleotide phosphodiesterase.
Topics: Amino Acids; Animals; Calcium; Fourier Analysis; Lysine; Magnetic Resonance Spectroscopy; Male; Nucleotides, Cyclic; Peptide Fragments; Phosphoric Diester Hydrolases; Protein Conformation; Proteins; Rats; Testis; Thermolysin | 1977 |
Calcium dependent activator protein of cyclic nucleotide phosphodiesterase from rat and bovine brain; presence of N-epsilon-trimethyllysine residue.
Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; Animals; Brain Chemistry; Calcium; Cattle; Enzyme Activation; Lysine; Methylation; Nerve Tissue Proteins; Phosphoric Diester Hydrolases; Rats | 1978 |
The role of the kidney in the biosynthesis of carnitine in the rat.
Topics: Animals; Carnitine; Isotope Labeling; Kidney; Kinetics; Liver; Lysine; Nephrectomy; Organ Specificity; Rats; Tritium | 1979 |
Methylations of 70,000-Da heat shock proteins in 3T3 cells: alterations by arsenite treatment, by different stages of growth and by virus transformation.
Topics: 3T3 Cells; Animals; Arginine; Arsenic; Arsenites; Avian Sarcoma Viruses; Cell Division; Cell Transformation, Viral; Chromatography, Ion Exchange; Electrophoresis, Gel, Two-Dimensional; Heat-Shock Proteins; Lysine; Methionine; Methylation; Mice; Molecular Weight; omega-N-Methylarginine | 1992 |
Further investigations regarding the role of trimethyllysine for cytochrome c uptake into mitochondria.
Topics: Animals; Arginine; Base Sequence; Cloning, Molecular; Codon; Cytochrome c Group; Cytochromes c; Lysine; Methylation; Mitochondria; Mitochondria, Liver; Molecular Sequence Data; Mutagenesis, Site-Directed; Polymerase Chain Reaction; Protein Biosynthesis; Rats; Restriction Mapping; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Structure-Activity Relationship; Transcription, Genetic | 1991 |
High concentration of free trimethyllysine in red blood cells.
Topics: Amino Acids; Animals; Chickens; Chromatography, High Pressure Liquid; Chromatography, Paper; Chromatography, Thin Layer; Dogs; Erythrocytes; Humans; Lysine; Macaca; Mice; Mice, Inbred C57BL; Rabbits; Rats; Rats, Inbred Strains; Reticulocytes | 1990 |
Soluble calcium-binding proteins: parvalbumins and calmodulin from eel skeletal muscle.
Topics: Anguilla; Animals; Calcium-Binding Proteins; Calmodulin; Lysine; Muscle Proteins; Muscles; Parvalbumins; Solubility; Troponin; Troponin C | 1990 |
Tissue trimethyllysine biosynthesis and carnitine content in pregnant and lactating rats fed a lysine-limiting diet.
Topics: Animals; Animals, Newborn; Carnitine; Diet; Female; Kinetics; Lactation; Liver; Lysine; Male; Maternal-Fetal Exchange; Milk; Muscles; Myocardium; Pregnancy; Pregnancy, Animal; Rats; Rats, Inbred Strains; Saccharopine Dehydrogenases; Tissue Distribution | 1990 |
Covalent crosslinking of myosin subfragment-1 and heavy meromyosin to actin at various molar ratios: different correlations between ATPase activity and crosslinking extent.
Topics: Actins; Animals; Ca(2+) Mg(2+)-ATPase; Chymotrypsin; Cross-Linking Reagents; Ethyldimethylaminopropyl Carbodiimide; Kinetics; Lysine; Mercaptoethanol; Myosin Subfragments; Rabbits | 1990 |
Location of seven post-translational modifications in rabbit elongation factor 1 alpha including dimethyllysine, trimethyllysine, and glycerylphosphorylethanolamine.
Topics: Amino Acid Sequence; Animals; Cyanogen Bromide; Lysine; Mass Spectrometry; Molecular Sequence Data; Oxidation-Reduction; Peptide Elongation Factor 1; Peptide Elongation Factors; Peptide Fragments; Phosphatidylethanolamines; Protein Conformation; Protein Processing, Post-Translational; Rabbits; Reticulocytes; Ribonucleoproteins; Trypsin | 1989 |
Butyrobetaine availability in liver is a regulatory factor for carnitine biosynthesis in rat. Flux through butyrobetaine hydroxylase in fasting state.
Topics: Animals; Betaine; Biological Availability; Carnitine; Fasting; gamma-Butyrobetaine Dioxygenase; Liver; Lysine; Male; Mixed Function Oxygenases; Rats; Rats, Inbred Strains; Whole-Body Counting | 1989 |
Utilization of dietary precursors for carnitine synthesis in human adults.
Topics: Adult; Betaine; Carnitine; Diet, Vegetarian; Dietary Proteins; Female; Humans; Lysine; Male; Methionine; Muscles; Nutritional Requirements; Protein Precursors | 1989 |
S-adenosylmethionine: epsilon-N-L-lysine methyltransferase.
Topics: Chromatography, Gel; Chromatography, Ion Exchange; Fungal Proteins; Lysine; Methyltransferases; Neurospora; Neurospora crassa | 1986 |
Trimethyllysine and protein function. Effect of methylation and mutagenesis of lysine 115 of calmodulin on NAD kinase activation.
Topics: Amino Acid Sequence; Calmodulin; Chlamydomonas; Dictyostelium; Enzyme Activation; Genes, Synthetic; Lysine; Methylation; Methyltransferases; Phosphotransferases; Phosphotransferases (Alcohol Group Acceptor); Protein Processing, Post-Translational; Recombinant Proteins | 1986 |
epsilon-N-trimethyllysine availability regulates the rate of carnitine biosynthesis in the growing rat.
Topics: Administration, Oral; Animals; Biological Availability; Body Weight; Carnitine; Injections, Intravenous; Lysine; Male; Mixed Function Oxygenases; Organ Size; Rats; Rats, Inbred Strains; Tissue Distribution; Tritium | 1986 |
Effect of starvation on the disposition of free and peptide-linked trimethyllysine in the rat.
Topics: Animals; Carnitine; Kidney; Liver; Lysine; Male; Muscles; Rats; Rats, Inbred Strains; Starvation | 1986 |
Synthesis of carnitine precursors and related compounds.
Topics: Amines; Animals; Betaine; Carnitine; Hydroxylysine; Lysine; Rats | 1986 |
A synthesis of N6,N6,N6-trimethyl-L-lysine dioxalate in gram amounts.
Topics: Animals; Indicators and Reagents; Lysine | 1986 |
Identification of epsilon-N-mono-, epsilon-N-di-, and epsilon-N-trimethyllysine by high-performance liquid chromatography.
Topics: Chromatography, High Pressure Liquid; Lysine | 1986 |
Proton nuclear magnetic resonance studies on the kinetics of tryptic fragments of calmodulin upon calcium binding.
Topics: Animals; Calcium; Calmodulin; Kinetics; Lysine; Magnetic Resonance Spectroscopy; Mollusca; Peptide Fragments; Phenylalanine; Protein Conformation; Trypsin; Tyrosine | 1986 |
Inter-tissue relationships in the synthesis and distribution of carnitine.
Topics: Animals; Carnitine; Glycine Hydroxymethyltransferase; Histone-Lysine N-Methyltransferase; Kidney; Liver; Lysine; Rats; Tissue Distribution | 1986 |
Potential role of carnitine in patients with renal insufficiency.
Topics: Acetylcarnitine; Carnitine; Carnitine O-Palmitoyltransferase; Creatinine; Humans; Hyperlipidemias; Kidney Failure, Chronic; Kidney Transplantation; Kidney Tubules, Proximal; Lysine; Muscles; Peritoneal Dialysis; Peritoneal Dialysis, Continuous Ambulatory; Renal Dialysis; Rhabdomyolysis; Uremia | 1986 |
Mechanism of increased hepatic concentration of carnitine by clofibrate.
Topics: Animals; Carnitine; Clofibrate; Esterification; Liver; Lysine; Male; Rats; Rats, Inbred Strains; Thyroidectomy | 1986 |
Improved high-performance liquid chromatographic method for the determination of 6-N,N,N-trimethyllysine in plasma and urine: biomedical application of chromatographic figures of merit and amine mobile phase modifiers.
Topics: Animals; Chromatography, High Pressure Liquid; Drug Stability; Humans; Hydrolysis; Lysine; Male; Rats; Rats, Inbred Strains | 1986 |
gamma-Butyrobetaine hydroxylase activity is not rate limiting for carnitine biosynthesis in the human infant.
Topics: Adolescent; Adult; Aged; Aging; Betaine; Carnitine; Child, Preschool; Female; gamma-Butyrobetaine Dioxygenase; Humans; Infant; Infant, Newborn; Kidney; Liver; Lysine; Male; Middle Aged; Mixed Function Oxygenases | 1987 |
Measurement of epsilon-N-trimethyllysine in human blood plasma and urine.
Topics: Amino Acids; Carnitine; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Humans; Lysine; Spectrometry, Fluorescence | 1987 |
Rise in plasma trimethyllysine levels in humans after oral lysine load.
Topics: Administration, Oral; Adult; Carnitine; Humans; Lysine; Male; Time Factors; Tryptophan | 1987 |
Plasma levels of carnitine precursor 6-N-trimethyllysine and maintenance hemodialysis.
Topics: Adolescent; Adult; Carnitine; Chromatography, High Pressure Liquid; Female; Humans; Kidney Failure, Chronic; Lysine; Male; Middle Aged; Renal Dialysis | 1987 |
The Journal of Biological Chemistry. Volume 248, 1973: Role of lysine and epsilon-n-trimethyllysine in carnitine biosynthesis. II. Studies in the rat. By Vichai Tanphaichitr and Harry P. Broquist.
Topics: Animals; Carnitine; History, 20th Century; Lysine; Male; Rats | 1988 |
Characterization of mutant TMK368K pig citrate synthase expressed in and isolated from Escherichia coli.
Topics: Acetyl Coenzyme A; Amino Acid Sequence; Amino Acids; Animals; Citrate (si)-Synthase; Cloning, Molecular; DNA; Escherichia coli; Immunoblotting; Kinetics; Lysine; Macromolecular Substances; Molecular Sequence Data; Mutation; Oxaloacetates; Oxo-Acid-Lyases; Peptide Fragments; Plasmids; Structure-Activity Relationship; Swine | 1988 |
Carnitine synthesis in scorbutic guinea pigs.
Topics: Animals; Carnitine; gamma-Aminobutyric Acid; Guinea Pigs; Hydroxylation; Lysine; Male; Scurvy; Tissue Distribution | 1985 |
High-performance liquid chromatographic determination of plasma free trimethyllysine in humans.
Topics: Adult; Autoanalysis; Chromatography, High Pressure Liquid; Humans; Indicators and Reagents; Lysine; Male; Middle Aged; Spectrometry, Fluorescence | 1985 |
Examination of the tumour growth promoting effect of -N-trimethyllysine. An autoradiographic study.
Topics: Animals; Ascites; Autoradiography; Female; Lymphoma; Lysine; Methylation; Mice; Mitosis; Neoplasms, Experimental; Thymidine; Time Factors; Tritium | 1971 |
[Carnitine biosynthesis in mammals].
Topics: Age Factors; Animals; Betaine; Carnitine; Humans; Lysine; Mammals; Methionine; Neurospora crassa; Tissue Distribution | 1982 |
Ca2+-binding proteins in crayfish abdominal muscle. Evidence for a calmodulin lacking trimethyllysine.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Amino Acids; Animals; Astacoidea; Brain; Calmodulin; Cattle; Cyclic AMP; Lysine; Muscles; Species Specificity | 1984 |
Determination of 6-N-trimethyllysine in urine by high-performance liquid chromatography.
Topics: Chromatography, Gel; Chromatography, High Pressure Liquid; Dinitrofluorobenzene; Female; Humans; Lysine; Spectrophotometry | 1983 |
Effect of starvation in the rat on trimethyllysine in peptide linkage.
Topics: Animals; Body Weight; Brain; Carnitine; Lysine; Male; Muscles; Peptides; Rats; Rats, Inbred Strains; Starvation; Tissue Distribution | 1983 |
The effect of E-N-trimethyl lysine (TML) treatment on the regeneration of bone marrow and intestinal mucosa in mice.
Topics: Animals; Bone Marrow; Female; Hematocrit; Intestinal Mucosa; Lysine; Male; Mice; Mice, Inbred DBA; Mitosis; Regeneration; Whole-Body Irradiation | 1983 |
Amino acid sequence of Acanthamoeba actin.
Topics: Actins; Amino Acid Sequence; Amoeba; Animals; Cysteine; Lysine; Methylhistidines | 1984 |
Determination of free trimethyllysine in plasma and tissue specimens by high-performance liquid chromatography.
Topics: Animals; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Humans; Lysine; Rats; Spectrometry, Fluorescence; Tissue Distribution | 1984 |
Carnitine biosynthesis from gamma-butyrobetaine and from exogenous protein-bound 6-N-trimethyl-L-lysine by the perfused guinea pig liver. Effect of ascorbate deficiency on the in situ activity of gamma-butyrobetaine hydroxylase.
Topics: Animals; Ascorbic Acid Deficiency; Betaine; Carbon Radioisotopes; Carnitine; gamma-Butyrobetaine Dioxygenase; Guinea Pigs; Liver; Lysine; Male; Methylation; Mixed Function Oxygenases; Orosomucoid; Perfusion; Tissue Distribution; Tritium | 1984 |
Methylated lysines and 3-methylhistidine in myosin: tissue and developmental differences.
Topics: Amino Acid Sequence; Amino Acids; Animals; Chick Embryo; Histidine; Lysine; Methylation; Methylhistidines; Muscles; Myocardium; Myosins; Plants; Polyribosomes; Rabbits; Radioisotope Dilution Technique; S-Adenosylmethionine; Triticum; Tritium | 1984 |
Synthesis of carnitine from epsilon-N-trimethyllysine in post mitochondrial fractions of Neurospora crassa.
Topics: Betaine; Carnitine; Cell-Free System; Cytosol; Lysine; Mitochondria; Neurospora; Neurospora crassa; Subcellular Fractions | 1980 |
epsilon-N-trimethyl-lysine: a natural cell component with mitogenic activity.
Topics: Adult; Autoradiography; Cells, Cultured; DNA; Female; Histones; Humans; Hydroxyurea; Lymphocyte Activation; Lymphocytes; Lysine; Male; Middle Aged; Mitogens; Phytohemagglutinins; Sex Factors; Time Factors | 1980 |
Tissue distribution of carnitine biosynthetic enzymes in man.
Topics: Adolescent; Adult; Aging; Aldehyde Dehydrogenase; Aldehyde Oxidoreductases; Aldehyde-Lyases; Carnitine; Child; Child, Preschool; Female; gamma-Butyrobetaine Dioxygenase; Glucuronates; Humans; Infant; Kinetics; Lactones; Lysine; Male; Middle Aged; Mixed Function Oxygenases; Organ Specificity; Tissue Distribution | 1980 |
N6-Trimethyl-lysine metabolism. 3-Hydroxy-N6-trimethyl-lysine and carnitine biosynthesis.
Topics: Animals; Carbon Radioisotopes; Carnitine; Chemical Phenomena; Chemistry; Chromatography, Thin Layer; Hydroxylysine; Kidney; Liver; Lysine; Models, Biological; Rats; Tritium | 1980 |
N6-Trimethyl-lysine metabolism. Structural identification of the metabolite 3-hydroxy-N6-trimethyl-lysine.
Topics: Carbon Radioisotopes; Hydroxylysine; Lysine; Magnetic Resonance Spectroscopy; Molecular Conformation; Tritium | 1980 |
Carnitine biosynthesis. Hydroxylation of N6-trimethyl-lysine to 3-hydroxy-N6-trimethyl-lysine.
Topics: Animals; Calcium; Carnitine; Cations, Divalent; Edetic Acid; Hydroxylation; In Vitro Techniques; Kidney; Kinetics; Lysine; Male; Mixed Function Oxygenases; Proteins; Rats; Subcellular Fractions | 1980 |
Significance of renal gamma-butyrobetaine hydroxylase for carnitine biosynthesis in man.
Topics: Adult; Animals; Brain; Carnitine; gamma-Butyrobetaine Dioxygenase; Humans; Kidney; Liver; Lysine; Male; Mixed Function Oxygenases; Muscles; Myocardium; Organ Specificity; Rats; Species Specificity | 1980 |
Methylation-like reaction of [3H-methyl]-N-5-trimethyllysine (TML) to chromatin components.
Topics: Animals; Chromatin; DNA; Lysine; Methylation; Mice; Molecular Weight; Neoplasms, Experimental | 1980 |
[E-N-trimethyl-lysine: a natural cellular component with mitogenic activity].
Topics: Humans; Lectins; Lymphocyte Activation; Lymphocytes; Lysine; Mitogens; Mitosis | 1980 |
Identification of methylated amino acids during sequence analysis. Application to the Escherichia coli ribosomal protein L11.
Topics: Alanine; Amino Acid Sequence; Chemical Phenomena; Chemistry; Chromatography, Thin Layer; Dipeptides; Escherichia coli; Lysine; Mass Spectrometry; Ribosomal Proteins | 1980 |
Effect of ascorbic acid deficiency on the in vivo synthesis of carnitine.
Topics: Animals; Ascorbic Acid Deficiency; Body Weight; Carnitine; gamma-Aminobutyric Acid; Guinea Pigs; Kidney; Liver; Lysine; Male; Muscles; Myocardium; Organ Size | 1981 |
Primary systemic carnitine deficiency: I. Carnitine biosynthesis.
Topics: Adult; Carnitine; Child; Chromatography, Ion Exchange; Female; Humans; Lysine; Male | 1981 |
Bioavailability of some lysine derivatives in mice.
Topics: Animals; Biological Assay; Biological Availability; Body Weight; Cysteine; Dietary Proteins; Lysine; Mice; Structure-Activity Relationship | 1981 |
Carnitine biosynthesis by the perfused rat liver from exogenous protein-bound trimethyllysine. Metabolism of methylated lysine derivatives arising from the degradation of 6-N-[methyl-3H]lysine-labeled glycoproteins.
Topics: Animals; Carnitine; Glycoproteins; Kinetics; Liver; Lysine; Male; Mitogens; Perfusion; Rats; Rats, Inbred Strains | 1981 |
Primary structure of porcine heart citrate synthase.
Topics: Amino Acid Sequence; Animals; Citrate (si)-Synthase; Cysteine; Lysine; Molecular Weight; Myocardium; Oxo-Acid-Lyases; Peptide Fragments; Swine | 1981 |
The use of a tritium release assay to measure 6-N-trimethyl-L-lysine hydroxylase activity: synthesis of 6-N-[3-3H]trimethyl-DL-lysine.
Topics: Animals; Isotope Labeling; Kidney; Kinetics; Liver; Lysine; Male; Mixed Function Oxygenases; Muscles; Myocardium; Radioisotope Dilution Technique; Rats; Rats, Inbred Strains; Tritium | 1981 |
The effects of 1-amino-D-proline on the production of carnitine from exogenous protein-bound trimethyllysine by the perfused rat liver.
Topics: Animals; Carnitine; In Vitro Techniques; Kinetics; Liver; Lysine; Male; Mitogens; Perfusion; Proline; Rats; Rats, Inbred Strains | 1982 |
Properties of rat 6-N-trimethyl-L-lysine hydroxylases: similarities among the kidney, liver, heart, and skeletal muscle activities.
Topics: Animals; Isoenzymes; Kidney; Kinetics; Liver; Lysine; Metals; Mixed Function Oxygenases; Muscles; Myocardium; Rats; Sulfhydryl Reagents | 1982 |
Carnitine biosynthesis and function. Introductory remarks.
Topics: Animals; Carnitine; Carnitine Acyltransferases; Cattle; Chemical Phenomena; Chemistry; Cytoplasm; Fatty Acids; Humans; Intracellular Membranes; Liver; Lysine; Mitochondria; Rats | 1982 |
Mammalian enzymes of trimethyllysine conversion to trimethylaminobutyrate.
Topics: Aldehyde Oxidoreductases; Animals; Carnitine; Cattle; Chemical Phenomena; Chemistry; gamma-Aminobutyric Acid; Glycine Hydroxymethyltransferase; Guinea Pigs; Kidney; Kinetics; Liver; Lysine; Mitochondria, Liver; Mixed Function Oxygenases; Rats | 1982 |
Sites and regulation of carnitine biosynthesis in mammals.
Topics: Adult; Animals; Animals, Suckling; Brain; Carnitine; Cats; Chemical Phenomena; Chemistry; Chromatography, Ion Exchange; Cricetinae; Dogs; gamma-Butyrobetaine Dioxygenase; Guinea Pigs; Haplorhini; Humans; Kidney; Liver; Lysine; Male; Mice; Mixed Function Oxygenases; Rabbits; Rats | 1982 |
Combined effect of cytostatic drugs and E-N-L-trimethyl lysine in healthy and transplantable tumor bearing mice.
Topics: Animals; Antineoplastic Agents; Cyclophosphamide; Doxorubicin; Drug Therapy, Combination; Female; Lysine; Male; Mice; Mice, Inbred Strains; Mitogens; Neoplasm Transplantation; Neoplasms, Experimental; Vincristine | 1982 |
The effect of E-N-L-trimethyllysine (TML) on the humoral and cellular immune response.
Topics: Animals; Antibody Formation; Female; Immunity, Cellular; Leukemia L1210; Levamisole; Lymphocytes; Lysine; Male; Mice; Time Factors; Whole-Body Irradiation | 1982 |
Mitochondrial ATP synthase subunit c stored in hereditary ceroid-lipofuscinosis contains trimethyl-lysine.
Topics: Adolescent; Adult; Amino Acid Sequence; Animals; Autopsy; Brain; Cytoplasmic Granules; Electrophoresis, Polyacrylamide Gel; Humans; Lysine; Macromolecular Substances; Mice; Mitochondria; Molecular Sequence Data; Neuronal Ceroid-Lipofuscinoses; Proton-Translocating ATPases; Rodent Diseases; Sheep; Sheep Diseases | 1995 |
Canine hereditary ceroid-lipofuscinosis: evidence for a defect in the carnitine biosynthetic pathway.
Topics: Animals; Biomarkers; Carnitine; Dog Diseases; Dogs; Genetic Carrier Screening; Homozygote; Humans; Lysine; Macromolecular Substances; Mammals; Mitochondria; Neuronal Ceroid-Lipofuscinoses; Proton-Translocating ATPases; Reference Values | 1995 |
The ability of guinea pigs to synthesize carnitine at a normal rate from epsilon-N-trimethyllysine or gamma-butyrobetaine in vivo is not compromised by experimental vitamin C deficiency.
Topics: Analysis of Variance; Animals; Ascorbic Acid Deficiency; Betaine; Carnitine; Food, Fortified; Guinea Pigs; Lysine; Male; Reference Values; Time Factors; Weight Gain | 1995 |
Primary structure and post-translational modification of ferredoxin-NADP reductase from Chlamydomonas reinhardtii.
Topics: Amino Acid Sequence; Animals; Base Sequence; Chlamydomonas reinhardtii; DNA, Complementary; Ferredoxin-NADP Reductase; Lysine; Mass Spectrometry; Molecular Sequence Data; Peptide Fragments; Protein Processing, Post-Translational; Sequence Analysis; Sequence Homology, Amino Acid; Species Specificity | 1995 |
The effect of amino acids and amino acid derivatives on cell proliferation.
Topics: Amino Acids; Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Ehrlich Tumor; Cell Death; Cell Division; Cells, Cultured; Doxorubicin; Drug Therapy, Combination; Leucine; Lymphoma; Lysine; Macrophages; Mice; Neoplasm Transplantation; Neoplasms, Experimental; Rats; Rats, Wistar; Sarcoma, Experimental; Sarcoma, Yoshida; Tumor Cells, Cultured | 1993 |
The relationship between the trimethylation of lysine 77 and cytochrome c metabolism in Saccharomyces cerevisiae.
Topics: Amino Acid Sequence; Base Sequence; Binding Sites; Cloning, Molecular; Cytochrome c Group; DNA Restriction Enzymes; Drug Stability; Gene Transfer Techniques; Heme; Lysine; Methylation; Molecular Sequence Data; Mutagenesis, Site-Directed; Plasmids; Saccharomyces cerevisiae | 1994 |
Characterization of trimethyllysine 115 in calmodulin by 14N and 13C NMR spectroscopy.
Topics: Amino Acid Sequence; Animals; Base Sequence; Calcium; Calmodulin; Carbon Isotopes; Cattle; Cloning, Molecular; Gene Expression; Glutamine; Hydrogen-Ion Concentration; Lysine; Magnetic Resonance Spectroscopy; Molecular Sequence Data; Mutagenesis, Site-Directed; Myosin-Light-Chain Kinase; Nitrogen; Oligodeoxyribonucleotides; Protein Conformation; Recombinant Proteins | 1994 |
Lysine methylation of mitochondrial ATP synthase subunit c stored in tissues of dogs with hereditary ceroid lipofuscinosis.
Topics: Amino Acid Sequence; Animals; Brain; Dog Diseases; Dogs; Humans; Kidney; Lysine; Lysosomes; Macromolecular Substances; Methylation; Mitochondria; Molecular Sequence Data; Neuronal Ceroid-Lipofuscinoses; Proton-Translocating ATPases; Sheep | 1994 |
Relationship of carnitine and carnitine precursors lysine, epsilon-N-trimethyllysine, and gamma-butyrobetaine in drug-induced carnitine depletion.
Topics: Adolescent; Bacteriuria; Betaine; Carnitine; Child; Child, Preschool; Creatinine; Epilepsy; Female; Humans; Lysine; Male; Pivampicillin; Urinary Tract Infections; Valproic Acid | 1993 |
Effects of charged amino acid mutations on the bimolecular kinetics of reduction of yeast iso-1-ferricytochrome c by bovine ferrocytochrome b5.
Topics: Amino Acid Sequence; Animals; Binding Sites; Cattle; Cytochrome c Group; Cytochromes b5; Cytochromes c; Heme; Histidine; Kinetics; Liver; Lysine; Mutagenesis, Site-Directed; Oxidation-Reduction; Protein Conformation; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins | 1993 |
Characterization of yeast EF-1 alpha: non-conservation of post-translational modifications.
Topics: Amino Acid Sequence; Cyanogen Bromide; Endopeptidases; Lysine; Methylation; Molecular Sequence Data; Peptide Elongation Factor 1; Peptide Elongation Factors; Protein Processing, Post-Translational; Saccharomyces cerevisiae; Sequence Alignment; Trypsin | 1993 |
Excess dietary lysine increases skeletal muscle and plasma trimethyllysine in rats.
Topics: Animals; Carnitine; Diet; Heart; Liver; Lysine; Male; Muscles; Myocardium; Proline; Rats; Rats, Sprague-Dawley | 1993 |
Generation of hydroxytrimethyllysine from trimethyllysine limits the carnitine biosynthesis in premature infants.
Topics: Carnitine; Humans; Infant, Newborn; Infant, Premature; Lysine; Male; Spectrometry, Mass, Fast Atom Bombardment | 1996 |
Decreased plasma carnitine and trimethyl-L-lysine levels associated with lysosomal accumulation of a trimethyl-L-lysine containing protein in Batten disease.
Topics: Adult; Carnitine; Child; Female; Heterozygote; Humans; Lysine; Male; Neuronal Ceroid-Lipofuscinoses | 1996 |
Late-infantile ceroid-lipofuscinosis: lysine methylation of mitochondrial ATP synthase subunit c from lysosomal storage bodies.
Topics: Cerebral Cortex; Humans; Infant; Lysine; Lysosomes; Mitochondria; Mitochondrial Proton-Translocating ATPases; Mucolipidoses; Proton-Translocating ATPases; Vitamin U | 1997 |
Labeled trimethyllysine load depletes unlabeled carnitine in premature infants without evidence of incorporation.
Topics: Carnitine; Dose-Response Relationship, Drug; Humans; Infant, Newborn; Infant, Premature; Lysine; Male; Protein Precursors; Spectrometry, Mass, Fast Atom Bombardment; Time Factors | 1999 |
Measurement of carnitine precursors, epsilon-trimethyllysine and gamma-butyrobetaine in human serum by tandem mass spectrometry.
Topics: Betaine; Carnitine; Humans; Lysine; Mass Spectrometry; Methylation; Reference Standards; Sensitivity and Specificity | 1999 |
Determinants of cytochrome c pro-apoptotic activity. The role of lysine 72 trimethylation.
Topics: Amino Acid Sequence; Animals; Apoptosis; Cytochrome c Group; Cytochromes c; Horses; Lysine; Methylation; Mitochondria; Models, Molecular; Molecular Sequence Data; Oocytes; Peptide Hydrolases; Protein Isoforms; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sequence Homology, Amino Acid; Xenopus | 2000 |
Decreased carnitine biosynthesis in rats with secondary biliary cirrhosis.
Topics: Animals; Betaine; Bile Ducts; Carnitine; Ligation; Liver Cirrhosis, Biliary; Lysine; Male; Rats; Rats, Sprague-Dawley; Reference Values | 2000 |
Structure of HP1 chromodomain bound to a lysine 9-methylated histone H3 tail.
Topics: Amino Acid Motifs; Amino Acid Sequence; Chromobox Protein Homolog 5; Chromosomal Proteins, Non-Histone; Crystallography, X-Ray; Drosophila Proteins; Histones; Hydrogen Bonding; Lysine; Methylation; Models, Molecular; Molecular Sequence Data; Mutagenesis; Peptides; Point Mutation; Protein Binding; Protein Conformation; Protein Structure, Secondary; Protein Structure, Tertiary; Sequence Alignment | 2002 |
Analysis of carnitine biosynthesis metabolites in urine by HPLC-electrospray tandem mass spectrometry.
Topics: Carnitine; Chromatography, High Pressure Liquid; Deuterium; Humans; Infant, Newborn; Lysine; Male; Reproducibility of Results; Sensitivity and Specificity; Spectrometry, Mass, Electrospray Ionization | 2002 |
Epsilon -N,N,N-trimethyllysine-specific ions in matrix-assisted laser desorption/ionization-tandem mass spectrometry.
Topics: Acetylation; Amino Acid Sequence; Animals; Erythrocytes; Histones; Lysine; Methylation; Molecular Sequence Data; Protein Processing, Post-Translational; Spectrometry, Mass, Electrospray Ionization; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2003 |
Efficient incorporation of positively charged 2', 3'-dideoxynucleoside-5'-triphosphates by DNA polymerases and their application in 'direct-load' DNA sequencing.
Topics: Base Sequence; Chromatography, High Pressure Liquid; Coloring Agents; Dideoxynucleosides; DNA; DNA-Directed DNA Polymerase; Lysine; Molecular Sequence Data; Molecular Structure; Nucleotides; Reproducibility of Results; Sensitivity and Specificity; Sequence Analysis, DNA | 2003 |
Spatial distribution of di- and tri-methyl lysine 36 of histone H3 at active genes.
Topics: Animals; Chickens; DNA Methylation; Gene Expression Regulation; Histones; Lysine | 2005 |
Carnitine deficiency and supplementation do not affect the gene expression of carnitine biosynthetic enzymes in rats.
Topics: Animals; Carnitine; Dietary Supplements; gamma-Butyrobetaine Dioxygenase; Gene Expression Regulation; Kidney; Liver; Lysine; Male; Mixed Function Oxygenases; Pentanoic Acids; Rats; RNA, Messenger | 2005 |
Histone H3 lysine 9 methylation and HP1gamma are associated with transcription elongation through mammalian chromatin.
Topics: Animals; Anion Exchange Protein 1, Erythrocyte; Cell Line; Cell Line, Tumor; Chromatin; Chromatin Immunoprecipitation; Chromobox Protein Homolog 5; Chromosomal Proteins, Non-Histone; Dichlororibofuranosylbenzimidazole; DNA-Binding Proteins; Erythroid Cells; Erythroid-Specific DNA-Binding Factors; GATA2 Transcription Factor; Globins; HeLa Cells; Histones; Humans; Interleukin-2; Kinetics; Liver; Lysine; Methylation; Mice; Phosphorylation; Protein Binding; Protein Isoforms; Proto-Oncogene Proteins c-kit; Proto-Oncogene Proteins c-myc; RNA Polymerase II; T-Lymphocytes; Transcription Factors; Transcription, Genetic | 2005 |
Catalytic roles for carbon-oxygen hydrogen bonding in SET domain lysine methyltransferases.
Topics: Arabidopsis; Binding Sites; Carbon; Catalysis; Cloning, Molecular; Histone-Lysine N-Methyltransferase; Hydrogen Bonding; Kinetics; Lysine; Oxygen; Protein Structure, Tertiary | 2006 |
Measurement of carnitine biosynthesis enzyme activities by tandem mass spectrometry: differences between the mouse and the rat.
Topics: Aldehyde Dehydrogenase; Aldehydes; Animals; Carnitine; Dioxygenases; gamma-Butyrobetaine Dioxygenase; Kinetics; Liver; Lysine; Male; Mass Spectrometry; Mice; Oxidoreductases; Rats; Species Specificity; Tissue Distribution | 2006 |
Kinetic manifestation of processivity during multiple methylations catalyzed by SET domain protein methyltransferases.
Topics: Adenosine; Animals; Catalysis; Cattle; Cell Cycle Proteins; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Kinetics; Lysine; Methylation; Methyltransferases; Models, Chemical; Multienzyme Complexes; Pisum sativum; Plant Proteins; Protein Methyltransferases; Protein Structure, Tertiary; S-Adenosylhomocysteine; Schizosaccharomyces pombe Proteins | 2007 |
Recognition of trimethyllysine by a chromodomain is not driven by the hydrophobic effect.
Topics: Amino Acid Sequence; Histones; Hydrophobic and Hydrophilic Interactions; Lysine; Methylation; Molecular Sequence Data; Protein Binding; Protein Structure, Tertiary; Thermodynamics | 2007 |
Specificity and mechanism of JMJD2A, a trimethyllysine-specific histone demethylase.
Topics: Amino Acid Sequence; Binding Sites; Computer Simulation; Crystallography, X-Ray; Histones; Humans; Jumonji Domain-Containing Histone Demethylases; Kinetics; Lysine; Models, Molecular; Molecular Sequence Data; Oxidoreductases, N-Demethylating; Substrate Specificity | 2007 |
Treatment with pharmacological peroxisome proliferator-activated receptor alpha agonist clofibrate causes upregulation of organic cation transporter 2 in liver and small intestine of rats.
Topics: Acyl-CoA Oxidase; Aldehyde-Lyases; Animals; Betaine; Carnitine; Carnitine O-Palmitoyltransferase; Clofibrate; Cytochrome P-450 CYP4A; gamma-Butyrobetaine Dioxygenase; Hypolipidemic Agents; Intestine, Small; Liver; Lysine; Male; Muscle, Skeletal; Organic Cation Transport Proteins; PPAR alpha; Rats; Rats, Sprague-Dawley; RNA, Messenger; Solute Carrier Family 22 Member 5; Up-Regulation | 2007 |
Loss of trimethylation at lysine 27 of histone H3 is a predictor of poor outcome in breast, ovarian, and pancreatic cancers.
Topics: Adult; Aged; Aged, 80 and over; Breast Neoplasms; Female; Histones; Humans; Lysine; Middle Aged; Ovarian Neoplasms; Pancreatic Neoplasms; Predictive Value of Tests; Prognosis; Treatment Failure; Treatment Outcome | 2008 |
PPAR alpha mediates transcriptional upregulation of novel organic cation transporters-2 and -3 and enzymes involved in hepatic carnitine synthesis.
Topics: Animals; Betaine; Body Weight; Carnitine; Liver; Lysine; Male; Membrane Proteins; Mice; Mice, Knockout; Organ Size; Organ Specificity; Organic Cation Transport Proteins; PPAR alpha; RNA, Messenger; Solute Carrier Family 22 Member 5; Transcription, Genetic; Up-Regulation | 2008 |
Post-translational modifications of Desulfovibrio vulgaris Hildenborough sulfate reduction pathway proteins.
Topics: Acetylation; Amino Acid Sequence; Bacterial Proteins; Chromatography, Liquid; Desulfovibrio desulfuricans; Desulfovibrio vulgaris; Hydrogensulfite Reductase; Lysine; Metabolic Networks and Pathways; Methylation; Models, Molecular; Molecular Sequence Data; Oxidation-Reduction; Oxidoreductases Acting on Sulfur Group Donors; Protein Conformation; Protein Processing, Post-Translational; Ribosomal Proteins; Sequence Homology, Amino Acid; Sulfate Adenylyltransferase; Sulfates; Tandem Mass Spectrometry | 2008 |
A moderate excess of dietary lysine lowers plasma and tissue carnitine concentrations in pigs.
Topics: Animal Feed; Animals; Betaine; Carnitine; gamma-Butyrobetaine Dioxygenase; Gene Expression; Kidney; Liver; Lysine; Male; Mixed Function Oxygenases; Muscles; Nutritional Status; Organic Cation Transport Proteins; Reverse Transcriptase Polymerase Chain Reaction; Swine | 2009 |
Methyl group migration during the fragmentation of singly charged ions of trimethyllysine-containing peptides: precaution of using MS/MS of singly charged ions for interrogating peptide methylation.
Topics: Arginine; Cell Line, Tumor; Histones; Humans; Lysine; Methylation; Peptide Fragments; Proline; Saccharomyces cerevisiae Proteins; Spectrometry, Mass, Electrospray Ionization; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2009 |
Determination of carnitine, its short chain acyl esters and metabolic precursors trimethyllysine and gamma-butyrobetaine by quasi-solid phase extraction and MS/MS detection.
Topics: Animals; Betaine; Carnitine; Esters; Humans; Lysine; Male; Solid Phase Extraction; Spectrometry, Mass, Electrospray Ionization; Swine; Tandem Mass Spectrometry | 2009 |
Role of the polycomb protein EED in the propagation of repressive histone marks.
Topics: Allosteric Regulation; Animals; Cell Line; Chromatin; Crystallography, X-Ray; Drosophila melanogaster; Drosophila Proteins; Enzyme Activation; Gene Silencing; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Models, Biological; Models, Molecular; Nuclear Proteins; Nucleosomes; Polycomb Repressive Complex 2; Protein Binding; Protein Structure, Tertiary; Repressor Proteins; Substrate Specificity | 2009 |
Importance of charge independent effects in readout of the trimethyllysine mark by HP1 chromodomain.
Topics: Chromobox Protein Homolog 5; Chromosomal Proteins, Non-Histone; Histones; Lysine; Molecular Dynamics Simulation; Protein Conformation; Thermodynamics; Time Factors | 2009 |
Low availability of carnitine precursors as a possible reason for the diminished plasma carnitine concentrations in pregnant women.
Topics: Adult; Anemia, Iron-Deficiency; Betaine; Carnitine; Erythrocyte Indices; Female; Ferritins; Germany; Hemoglobins; Humans; Linear Models; Lysine; Pregnancy; Pregnancy Complications, Hematologic; Pregnancy Trimester, Third | 2010 |
Biosynthesis of proteins containing modified lysines and fluorescent labels using non-natural amino acid mutagenesis.
Topics: Amino Acids; Aminoacylation; Cell-Free System; Escherichia coli; Fluorescent Dyes; Lysine; Mutagenesis; Protein Biosynthesis; Protein Engineering; Proteins; RNA, Transfer; Streptavidin | 2011 |
Purification and assay protocols for obtaining highly active Jumonji C demethylases.
Topics: Biochemistry; Chromatography, Affinity; Flavins; Fluorescence; Formaldehyde; Histones; Humans; Jumonji Domain-Containing Histone Demethylases; Kinetics; Lysine; Metals; Streptavidin; Substrate Specificity | 2012 |
Tuning HP1α chromodomain selectivity for di- and trimethyllysine.
Topics: Animals; Circular Dichroism; Drosophila; Fluorescence Polarization; Histones; Lysine; Methylation; Models, Molecular | 2011 |
Methylation of nuclear proteins of Novikoff hepatoma.
Topics: Animals; Cell Nucleus; Histones; Kinetics; Liver; Liver Neoplasms, Experimental; Lysine; Male; Methylation; Nuclear Proteins; Rats; Rats, Sprague-Dawley; S-Adenosylmethionine | 1980 |
Synthesis of new trisulfonated calix[4]arenes functionalized at the upper rim, and their complexation with the trimethyllysine epigenetic mark.
Topics: Calixarenes; Lysine; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Structure; Sulfonic Acids | 2012 |
The cation-π interaction at protein-protein interaction interfaces: developing and learning from synthetic mimics of proteins that bind methylated lysines.
Topics: Arginine; Calixarenes; Cations; Humans; Hydrogen Bonding; Lysine; Methylation; Phenols; Protein Interaction Maps; Proteins | 2013 |
Binding trimethyllysine and other cationic guests in water with a series of indole-derived hosts: large differences in affinity from subtle changes in structure.
Topics: Indoles; Lysine; Models, Molecular; Molecular Conformation; Propionates; Solutions; Substrate Specificity; Water | 2012 |
The carnitine biosynthetic pathway in Arabidopsis thaliana shares similar features with the pathway of mammals and fungi.
Topics: Animals; Arabidopsis; Betaine; Biosynthetic Pathways; Carnitine; Chromatography, Liquid; Deuterium; Fungi; Lipid Metabolism; Lysine; Mammals; Plant Extracts; Seedlings; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Vitamin B Complex | 2012 |
Mutation of trimethyllysine 72 to alanine enhances His79-heme-mediated dynamics of iso-1-cytochrome c.
Topics: Alanine; Amino Acid Substitution; Cytochromes c; Heme; Hydrogen-Ion Concentration; Kinetics; Lysine; Models, Molecular; Protein Conformation; Protein Denaturation; Protein Stability; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Thermodynamics | 2013 |
The Tudor domain of the PHD finger protein 1 is a dual reader of lysine trimethylation at lysine 36 of histone H3 and lysine 27 of histone variant H3t.
Topics: Amino Acid Sequence; Binding Sites; DNA-Binding Proteins; Genetic Variation; HEK293 Cells; Histones; Humans; Lysine; Methylation; Molecular Sequence Data; Mutagenesis, Site-Directed; Polycomb Repressive Complex 2; Polycomb-Group Proteins; Protein Binding; Protein Interaction Domains and Motifs; Recombinant Proteins; Sequence Homology, Amino Acid; Transcription Factors | 2014 |
The effect of the length of histone H3K4me3 on recognition by reader proteins.
Topics: Amino Acid Sequence; Animals; Binding Sites; Histones; Humans; Lysine; Mice; Models, Molecular; Molecular Sequence Data; Protein Interaction Mapping; Thermodynamics | 2013 |
Where does N(ε)-trimethyllysine for the carnitine biosynthesis in mammals come from?
Topics: Animals; Biosynthetic Pathways; Carnitine; Chromatography, Liquid; Chromatography, Reverse-Phase; Fluorescence; Lysine; Mammals; Plant Extracts; Spectrometry, Mass, Electrospray Ionization; Vegetables | 2014 |
Multimethylation of Rickettsia OmpB catalyzed by lysine methyltransferases.
Topics: Amino Acid Motifs; Bacterial Outer Membrane Proteins; Cell Membrane; Chromatography, Liquid; Kinetics; Lysine; Methylation; Methyltransferases; Plasmids; Protein Structure, Tertiary; Rickettsia prowazekii; Rickettsia typhi; Tandem Mass Spectrometry; Virulence | 2014 |
Inhibition of histone binding by supramolecular hosts.
Topics: Autoantigens; Calixarenes; Chromatin Assembly and Disassembly; Chromosomal Proteins, Non-Histone; Drug Design; Epigenesis, Genetic; HEK293 Cells; Histones; Homeodomain Proteins; Humans; Hypoxia-Inducible Factor-Proline Dioxygenases; Indicators and Reagents; Lysine; Methylation; Mi-2 Nucleosome Remodeling and Deacetylase Complex; Models, Molecular; Peptide Fragments; Protein Interaction Domains and Motifs; Protein Processing, Post-Translational; Protein Subunits; Recombinant Proteins | 2014 |
Chromodomain antagonists that target the polycomb-group methyllysine reader protein chromobox homolog 7 (CBX7).
Topics: Chromobox Protein Homolog 5; Chromosomal Proteins, Non-Histone; Crystallography, X-Ray; Fluorescence Polarization; Histones; Humans; Lysine; Models, Molecular; Molecular Structure; Peptide Fragments; Polycomb Repressive Complex 1; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Structure-Activity Relationship | 2014 |
Development and mechanistic studies of an optimized receptor for trimethyllysine using iterative redesign by dynamic combinatorial chemistry.
Topics: Binding Sites; Combinatorial Chemistry Techniques; Lysine; Models, Molecular; Molecular Structure; Protein Binding; Protein Processing, Post-Translational; Receptors, Drug; Small Molecule Libraries; Thermodynamics | 2014 |
Traceless semisynthesis of a set of histone 3 species bearing specific lysine methylation marks.
Topics: Amino Acid Sequence; HeLa Cells; Histones; Humans; Lysine; Methylation; Molecular Sequence Data; Nucleosomes; Protein Binding; Protein Processing, Post-Translational | 2014 |
A new type of protein lysine methyltransferase trimethylates Lys-79 of elongation factor 1A.
Topics: Amino Acid Motifs; Amino Acid Sequence; Computational Biology; Evolution, Molecular; Gene Deletion; Genotype; Histone-Lysine N-Methyltransferase; Lysine; Mass Spectrometry; Peptide Elongation Factor 1; Protein Processing, Post-Translational; S-Adenosylmethionine; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins | 2014 |
The response of Ω-loop D dynamics to truncation of trimethyllysine 72 of yeast iso-1-cytochrome c depends on the nature of loop deformation.
Topics: Cytochromes c; Hydrogen-Ion Concentration; Kinetics; Lysine; Models, Molecular; Saccharomyces cerevisiae; Sodium Chloride; Thermodynamics | 2015 |
Secondary Binding Interactions in a Synthetic Receptor for Trimethyllysine.
Topics: Arginine; Binding Sites; Humans; Lysine; Protein Binding; Receptors, Artificial; Thermodynamics | 2015 |
Chemical basis for the recognition of trimethyllysine by epigenetic reader proteins.
Topics: Acetyltransferases; Amino Acids, Aromatic; Antigens, Nuclear; Calorimetry; Crystallography, X-Ray; Epigenesis, Genetic; Histone Code; Histones; Humans; Jumonji Domain-Containing Histone Demethylases; Lysine; Methylation; Models, Molecular; Molecular Dynamics Simulation; Nerve Tissue Proteins; Quaternary Ammonium Compounds; Retinoblastoma-Binding Protein 2; TATA-Binding Protein Associated Factors; Transcription Factor TFIID; Transcription Factors | 2015 |
Statistical Correlations between NMR Spectroscopy and Direct Infusion FT-ICR Mass Spectrometry Aid Annotation of Unknowns in Metabolomics.
Topics: Animals; Lysine; Magnetic Resonance Spectroscopy; Mass Spectrometry; Metabolomics; Oligochaeta; Serine; Statistics as Topic; Succinic Acid; Tissue Extracts | 2016 |
The Carnitine-butyrobetaine-trimethylamine-N-oxide pathway and its association with cardiovascular mortality in patients with carotid atherosclerosis.
Topics: Aged; Betaine; Biomarkers; Carnitine; Carotid Stenosis; Case-Control Studies; Cause of Death; Chromatography, High Pressure Liquid; Female; Humans; Kaplan-Meier Estimate; Lysine; Male; Methylamines; Middle Aged; Myocardial Infarction; Prognosis; Proportional Hazards Models; Risk Assessment; Risk Factors; Severity of Illness Index; Stroke; Ultrasonography, Doppler, Color | 2016 |
Supramolecular Affinity Labeling of Histone Peptides Containing Trimethyllysine and Its Application to Histone Deacetylase Assays.
Topics: Amino Acid Sequence; Enzyme Assays; Fluorescent Dyes; Histone Deacetylases; Histones; Lysine; Methylation; Protein Processing, Post-Translational | 2016 |
Human carnitine biosynthesis proceeds via (2S,3S)-3-hydroxy-N
Topics: Biocatalysis; Carnitine; Humans; Lysine; Mixed Function Oxygenases; Models, Molecular; Protein Conformation; Stereoisomerism; Substrate Specificity | 2016 |
Evidence That Trimethyllysine Hydroxylase Catalyzes the Formation of (2S,3S)-3-Hydroxy-N
Topics: Biocatalysis; Carnitine; Humans; Lysine; Mixed Function Oxygenases; Molecular Structure | 2017 |
Fluorinated trimethyllysine as a
Topics: Biocatalysis; Fluorine; Halogenation; Humans; Lysine; Magnetic Resonance Spectroscopy; Mixed Function Oxygenases; Molecular Probes; Molecular Structure | 2017 |
Quantitative and Structural Assessment of Histone Methyllysine Analogue Engagement by Cognate Binding Proteins Reveals Affinity Decrements Relative to Those of Native Counterparts.
Topics: Amino Acid Sequence; Antigens, Nuclear; Histones; Humans; Lysine; Nerve Tissue Proteins; PHD Zinc Fingers; Protein Binding; Protein Processing, Post-Translational; Thermodynamics; Transcription Factors | 2018 |
Investigation of Trimethyllysine Binding by the HP1 Chromodomain via Unnatural Amino Acid Mutagenesis.
Topics: Animals; Chromosomal Proteins, Non-Histone; Drosophila melanogaster; Drosophila Proteins; Histones; Lysine; Mutagenesis; Protein Binding; Thermodynamics; Tyrosine | 2017 |
Robustness of In Vitro Selection Assays of DNA-Encoded Peptidomimetic Ligands to CBX7 and CBX8.
Topics: Biological Assay; DNA; Ligands; Lysine; Peptidomimetics; Polycomb Repressive Complex 1; Proteins; Sequence Analysis, DNA; Structure-Activity Relationship | 2018 |
Serum Carnitine Metabolites and Incident Type 2 Diabetes Mellitus in Patients With Suspected Stable Angina Pectoris.
Topics: Aged; Angina, Stable; Betaine; Body Mass Index; Carnitine; Chromatography, Liquid; Coronary Artery Disease; Diabetes Mellitus, Type 2; Esters; Female; Humans; Logistic Models; Lysine; Male; Middle Aged; Odds Ratio; Prospective Studies; Risk Factors | 2018 |
Recognition of shorter and longer trimethyllysine analogues by epigenetic reader proteins.
Topics: Carrier Proteins; Epigenesis, Genetic; Histones; Humans; Lysine; Molecular Dynamics Simulation; Molecular Structure; Ornithine; Peptide Fragments; Protein Binding; Quantum Theory; Thermodynamics | 2018 |
Untargeted metabolomics identifies trimethyllysine, a TMAO-producing nutrient precursor, as a predictor of incident cardiovascular disease risk.
Topics: Aged; Animals; Atherosclerosis; Cardiovascular Diseases; Carnitine; Cholesterol; Choline; Disease Models, Animal; Feces; Female; Gastrointestinal Microbiome; Genome-Wide Association Study; Humans; Lysine; Male; Metabolomics; Methylamines; Mice; Mice, Inbred C57BL; Middle Aged; Nutrients; Risk Factors; Thrombosis | 2018 |
Monitoring alkaline transitions of yeast iso-1 cytochrome c at natural isotopic abundance using trimethyllysine as a native NMR probe.
Topics: Alkalies; Cytochromes c1; Lysine; Magnetic Resonance Spectroscopy; Molecular Probes; Nitrogen; Protons; Saccharomyces cerevisiae | 2018 |
Installation of Trimethyllysine Analogs on Intact Histones via Cysteine Alkylation.
Topics: Alkylation; Animals; Cysteine; Electrophoresis, Polyacrylamide Gel; Histones; Humans; Lysine; Protein Processing, Post-Translational; Retinoblastoma-Binding Protein 2; Spectrometry, Mass, Electrospray Ionization; Xenopus laevis | 2019 |
Trimethyllysine, a trimethylamine N-oxide precursor, provides near- and long-term prognostic value in patients presenting with acute coronary syndromes.
Topics: Acute Coronary Syndrome; Aged; Female; Humans; Lysine; Male; Methylamines; Middle Aged; Prognosis; Prospective Studies | 2019 |
Microbial metabolites as predictive biomarkers: a paradigm shift for cardiovascular risk stratification.
Topics: Acute Coronary Syndrome; Biomarkers; Cardiovascular Diseases; Humans; Lysine; Methylamines; Prognosis; Risk Factors | 2019 |
A trimethyllysine-containing trityl tag for solubilizing hydrophobic peptides.
Topics: Amino Acid Sequence; Amino Acids; Hydrophobic and Hydrophilic Interactions; Lysine; Peptides; Solubility; Structure-Activity Relationship; Sulfonic Acids; Water | 2019 |
Circulating trimethyllysine and risk of acute myocardial infarction in patients with suspected stable coronary heart disease.
Topics: Aged; Biomarkers; Coronary Disease; Female; Heart Disease Risk Factors; Humans; Lysine; Male; Methylamines; Middle Aged; Myocardial Infarction; Prospective Studies; Riboflavin | 2020 |
Comparison of Molecular Recognition of Trimethyllysine and Trimethylthialysine by Epigenetic Reader Proteins.
Topics: Binding Sites; Cysteine; Epigenesis, Genetic; Histones; Humans; Lysine; Methylation; Models, Molecular; Molecular Conformation; Protein Binding; Solid-Phase Synthesis Techniques; Structure-Activity Relationship; Thermodynamics | 2020 |
Trimethyllysine and trimethylamine-N-oxide - pathogenic factors or surrogate markers of increased cardiovascular disease risk?
Topics: Biomarkers; Cardiovascular Diseases; Coronary Disease; Humans; Lysine; Methylamines; Myocardial Infarction; Oxides; Virulence Factors | 2020 |
Trimethyllysine, vascular risk factors and outcome in acute ischemic stroke (MARK-STROKE).
Topics: Aged; Aged, 80 and over; Biomarkers; Coronary Artery Disease; Female; Humans; Ischemic Stroke; Lysine; Male; Middle Aged; Prospective Studies; Risk Factors | 2021 |
Association Between Plasma Trimethyllysine and Prognosis of Patients With Ischemic Stroke.
Topics: Humans; Ischemic Attack, Transient; Ischemic Stroke; Lysine; Prognosis | 2021 |
Associations of plasma carnitine, lysine, trimethyllysine and glycine with incident ischemic stroke: Findings from a nested case-control study.
Topics: Carnitine; Case-Control Studies; Fabaceae; Glycine; Humans; Ischemic Stroke; Lysine; Stroke; Tandem Mass Spectrometry | 2022 |