lysine has been researched along with trichostatin a in 102 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (4.90) | 18.2507 |
| 2000's | 54 (52.94) | 29.6817 |
| 2010's | 37 (36.27) | 24.3611 |
| 2020's | 6 (5.88) | 2.80 |
| Authors | Studies |
|---|---|
| Schultz, RM; Turner, BM; Worrad, DM | 1 |
| O'Neill, LP; Turner, BM | 1 |
| Baranczewski, P; Belyaev, ND; Houben, A; Schubert, I | 1 |
| Waterborg, JH | 1 |
| Chen, WY; Townes, TM | 1 |
| Cox, LK; Ruh, MF; Ruh, TS; Tian, S | 1 |
| Angeletti, RH; Avantaggiati, ML; Fu, M; Ogryzko, V; Pestell, RG; Reutens, AT; Siconolfi-Baez, L; Wang, C; Wang, J | 1 |
| Barratt, MJ; Clayton, AL; Mahadevan, LC; Rose, S | 1 |
| Allis, CD; Briggs, SD; Erdjument-Bromage, H; Feng, Q; Huang, ZQ; Strahl, BD; Tempst, P; Wang, H; Wong, J; Xia, L; Zhang, Y | 1 |
| Costa, M; Peng, W; Sutherland, JE; Zhang, Q | 1 |
| Hedin, L; Jacob, AL; Lund, J; Martinez, P | 1 |
| Feil, R; Fournier, C; Gregory, RI; Khosla, S; O'Neill, LP; Randall, TE; Turner, BM | 1 |
| Kim, JY; Kim, KW; Kwon, HJ; Lee, DW; Yoo, JS | 1 |
| Issa, JP; Kondo, Y; Shen, L | 1 |
| Miller, R; Park, PH; Shukla, SD | 1 |
| Aoki, F; Kim, JM; Liu, H; Nagata, M; Tazaki, M | 1 |
| Chen, HB; Costa, M; Kluz, T; Yan, Y; Zhang, P | 1 |
| Dong, Z; Goto, H; Inagaki, M; Zhong, S | 1 |
| Daitoku, H; Fukamizu, A; Fukuoka, M; Hatta, M; Matsuzaki, H; Umemura, S | 1 |
| Kato, J; Matsunaga, T; Minami, S; Murakami, K; Murakami, T; Niitsu, Y; Takada, K; Takahashi, M; Takayama, T; Takimoto, R; Terui, T | 1 |
| Fu, M; Gioeli, D; Hessien, M; Pestell, RG; Rao, M; Wang, C; Weber, MJ; Wu, K; Yeung, YG; Zhang, X | 1 |
| Bae, SC; Choi, JK; Jeon, EJ; Jin, YH; Kim, WJ; Lee, KY; Lee, YH; Li, QL | 1 |
| Olashaw, N; Seto, E; Tsai, SC; Wharton, W; Yuan, Z; Zhang, X | 1 |
| De La Fuente, R; Eppig, JJ; Viveiros, MM; Wigglesworth, K | 1 |
| Conn, MT; Misialek, S; Schultz, BE; Tahilramani, R; Tang, J; Wong, L; Wu, J | 1 |
| Helliger, W; Koutzamani, E; Lindner, HH; Sarg, B; Talasz, H | 1 |
| Brattain, MG; Horowitz, JM; Kennett, SB; Moorefield, KS; Simmons, SO; Spengler, ML | 1 |
| Arai, D; Higashinakagawa, T; Matsuoka, O; Sakai, A; Shindo, N; Yamasaki, Y | 1 |
| Aoki, F; Endo, T; Kume, S; Naito, K; Tojo, H | 1 |
| Higashimoto, K; Joh, K; Kudo, S; Matsukura, S; Matsuo, S; Mukai, T; Nakagawachi, T; Soejima, H; Urano, T; Zhao, W | 1 |
| D'Abreo, C; Fish, JE; Lin, S; Marsden, PA; Matouk, CC; Rachlis, A; Tai, SC | 1 |
| Choi, EJ; Kim, JS; Kim, YH; Seo, JH; Whang, YM; Yoo, YD | 1 |
| Dufau, ML; Fatima, N; Zhang, Y | 1 |
| Horio, Y; Osada, H; Sugito, N; Takahashi, T; Tatematsu, Y | 1 |
| Hazzalin, CA; Mahadevan, LC | 1 |
| Han, YM; Kang, MJ; Kang, YK; Kim, JS; Koo, DB; Lee, KK; Moon, SJ; Song, BS; Wee, G | 1 |
| Chong, YT; Homenko, DR; Kim, MY; Kraus, WL; Woo, EM | 1 |
| Ai, JS; Chen, DY; Hou, Y; Liang, CG; Schatten, H; Sun, QY; Wang, Q; Yin, S | 1 |
| Hirai, A; Nakazono, M; Saika, H; Tsuji, H; Tsutsumi, N | 1 |
| Sommerville, J; Stewart, MD; Wong, J | 1 |
| Fang, S; Kemper, JK; Miao, J; Ponugoti, B; Treuter, E; Xiang, L | 1 |
| Huang, TH; Liu, JC; Plass, C; Potter, D; Smith, LT; Wang, SH; Wu, J; Wu, YZ | 1 |
| Fisher, AG; Frye, M; Watt, FM | 1 |
| Becker, PB; Bonaldi, T; Chioda, M; Eberharter, A; Ferreira, R; Imhof, A | 1 |
| Gao, S; Kou, Z; Wang, F; Zhang, Y | 1 |
| Chou, SD; Tomasi, TB | 1 |
| Horinouchi, S; Shimazu, T; Yoshida, M | 1 |
| Cooper, DA; Kelleher, AD; Lim, HG; Suzuki, K | 1 |
| Ai, JS; Chen, DY; Han, ZM; Huang, JC; Lei, ZL; Ouyang, YC; Shi, LH; Sun, QY; Wang, Q; Yin, S | 1 |
| Bonanno, E; Calvani, M; Mazzarelli, P; Pucci, S; Sesti, F; Spagnoli, LG | 1 |
| Bajbouj, K; Habold, C; Hartig, R; Korkmaz, KS; Poehlmann, A; Roessner, A; Schneider-Stock, R | 1 |
| An, XR; Chen, YF; Cui, XH; Guan, H; Hou, J; Liu, L; Yan, FX; Zhang, J | 1 |
| Bunch, TD; Fu, XW; Meng, QG; Pei, Y; Suo, L; Yan, CL; Zhu, SE | 1 |
| Chen, Y; Domann, FE; Hitchler, MJ; Weigel, RJ; Woodfield, GW | 1 |
| Hu, XZ; Jiang, H; Lipsky, RH; Marini, AM; Pan, H; Tian, F; Wu, X | 1 |
| Arthur, K; Diamond, J; Hamilton, PW; Maxwell, P; McKelvey-Martin, VJ; McKenna, DJ; Watson, JA | 1 |
| Kawahara, M; Sato, E; Sugimura, S; Wakai, T; Yamanaka, K | 1 |
| Cervera, RP; Escorihuela, E; Martí-Gutiérrez, N; Moreno, R; Stojkovic, M | 1 |
| Dai, DQ; Meng, CF; Peng, G; Zhu, XJ | 1 |
| Ito, T; Khochbin, S; Nishino, N; Sasaki, K; Yoshida, M | 1 |
| D'Orazi, G; Givol, D; Nardinocchi, L; Puca, R; Rechavi, G; Sacchi, A | 1 |
| Abdullaev, Z; Khafizova, M; Kondratyev, A; Loukinov, D; Yakovlev, A | 1 |
| Füllgrabe, J; Hajji, N; Hermanson, O; Joseph, B; Vlachos, P; Wallenborg, K | 1 |
| Chen, L; Dai, Y; Li, N; Li, Y; Liu, S; Ma, Y; Song, J; Wei, H; Xue, K; Zhao, Y | 1 |
| Godsey, S; Oyer, JA; Turker, MS; Yates, PA | 1 |
| Damante, G; Frasca, F; Passon, N; Puppin, C; Tomaciello, S; Tomay, F; Vigneri, R | 1 |
| Ichihara, E; Kaneda, K; Morishita, K; Nakahata, S; Nishikata, I; Saito, Y; Yamakawa, N | 1 |
| Alani, RM; Bowers, EM; Cole, PA; Crump, NT; Hazzalin, CA; Mahadevan, LC | 1 |
| Hayashi-Takanaka, Y; Kainuma, T; Kimura, H; Kurumizaka, H; Nozaki, N; Shinkai, Y; Stasevich, TJ; Tachibana, M; Tsurimoto, T; Wakayama, T; Yamagata, K | 1 |
| Chen, Y; Huang, C; Pan, K; Wang, W; Zhang, X | 1 |
| Shepard, BD; Tuma, DJ; Tuma, PL | 1 |
| Cavalli, LR; da Costa Prando, E; Rainho, CA | 1 |
| Ma, P; Montgomery, RL; Olson, EN; Pan, H; Schultz, RM | 1 |
| Kishimoto, T; Yamamura, N | 1 |
| Chubb, JR; Hsu, DW; Mahadevan, LC; Muramoto, T; Pears, CJ | 1 |
| Annunziato, AT; Hoffman, CS; Keller, T; Tong, K | 1 |
| Capogrossi, MC; Castellano, S; Colussi, C; Farsetti, A; Gaetano, C; Illi, B; Mai, A; Mattiussi, S; Rosati, J; Sbardella, G; Scopece, A; Spallotta, F; Vitale, S | 1 |
| Chen, PW; Li, H; Mellon, J; Niederkorn, JY; Sadegh, L | 1 |
| Camolotto, SA; Genti-Raimondi, S; Panzetta-Dutari, GM; Racca, AC; Ridano, ME | 1 |
| Hirasawa, N; Hiratsuka, M; Kotake, D; Sato, T | 1 |
| Chi, H; Hosoi, Y; Ito, A; Kishigami, S; Lee, AR; Matsubara, K; Matsumoto, K; Nishino, N; Yoshida, M | 1 |
| Cho, EJ; Choi, S; Irani, K; Jeon, BH; Joo, HK; Kim, CS; Kim, HS; Lee, YR; Park, JB; Park, MS | 1 |
| Fang, WL; Li, GM; Ma, JL; Shi, M; Wang, N; Wang, T; Wang, YG; Wei, J | 1 |
| An, L; Jaime-Frias, R; Kadiyala, V; Mathieu, W; Patrick, NM; Pookhao, N; Smith, CL | 1 |
| Dölle, C; Skoge, RH; Ziegler, M | 1 |
| Benz, CC; Gabriel, BS; Gibson, BW; Hanson, IM; Held, JM; Kehasse, A; Rothschild, DE; Schilling, B; Scott, GK; Wilson-Edell, KA; Yau, C; Yevtushenko, MA | 1 |
| Cui, Y; Guo, X; Guo, Y; Jiang, M; Sha, J; Sun, G; Zhou, T | 1 |
| Alsarraf, O; Chou, CJ; Crosson, CE; Dahrouj, M; Fan, J; Menick, DR | 1 |
| Jing, N; Qiao, Y; Tang, K; Wang, R; Yang, X | 1 |
| Ng, YK; Ong, WY; Tan, CS | 1 |
| Gan, YH; Jia, LF; Meng, Z | 1 |
| Cui, W; Galeva, N; Shen, X; Staudinger, JL; Sun, M; Williams, TD; Zhang, S | 1 |
| Chatdarong, K; Do, LT; Otoi, T; Sato, Y; Taniguchi, M; Techakumphu, M; Tharasanit, T; Wittayarat, M | 1 |
| Chen, J; Chen, Z; Ding, G; Gao, S; Li, J; Liu, X; Lu, L; Shi, T; Wang, Z; Wei, W; Wong, J; Yu, J; Zhang, H | 1 |
| Chen, YL; Ding, D; Hou, CJ; Liu, XP; Peng, JY; Tao, LL; Yin, WH | 1 |
| Gozda, K; Khorshid Ahmad, T; Kong, J; Lakowski, TM; Lillico, R; Namaka, M; Stesco, N; Truong, J; Zhou, T | 1 |
| Jiang, C; Liu, J; Liu, Y; Lv, J; Ma, Y; Nie, Z; Sheng, Q; Sun, Z; Wang, D; Wu, C; You, Z | 1 |
| Gu, C; Huang, K; Liu, D; Liu, Y; Zhao, B | 1 |
| Bomhard, A; Brückner, F; Lisowska, H; Lundholm, L; Płódowska, M; Sterr, C; Svetličič, M | 1 |
| Angrisano, T; Cozzolino, F; Iacobucci, I; Monaco, V; Monti, M | 1 |
| Ding, J; Hu, Z; Li, Y; Liao, X; Lin, Y; Zheng, B | 1 |
| Ahmad, R; Akhter, N; Al Madhoun, A; Al-Mulla, F; Al-Ozairi, E; Al-Roub, A; Jacob, T; Miranda, L; Sindhu, S; Thomas, R | 1 |
1 review(s) available for lysine and trichostatin a
| Article | Year |
|---|---|
[Biological diversity of protein lysine acetylation which has been revealed by small molecule inhibitors].
Topics: Acetylation; Animals; Antigens, Polyomavirus Transforming; Antineoplastic Agents; Cortactin; Enzyme Inhibitors; Histone Acetyltransferases; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; HSP90 Heat-Shock Proteins; Humans; Hydroxamic Acids; Lysine; mRNA Cleavage and Polyadenylation Factors; Neoplasms; Tubulin; Tumor Suppressor Protein p53 | 2007 |
101 other study(ies) available for lysine and trichostatin a
| Article | Year |
|---|---|
Temporally restricted spatial localization of acetylated isoforms of histone H4 and RNA polymerase II in the 2-cell mouse embryo.
Topics: Acetylation; Animals; Anti-Bacterial Agents; Chromatin; DNA Replication; Fluorescent Antibody Technique; Gene Expression Regulation, Developmental; Histone Deacetylase Inhibitors; Histones; Hydroxamic Acids; Immunoblotting; Isoenzymes; Lysine; Mice; Mice, Inbred Strains; Microscopy, Confocal; Nucleic Acid Conformation; Peptides; RNA Polymerase II; Transcriptional Activation; Zygote | 1995 |
Histone H4 acetylation distinguishes coding regions of the human genome from heterochromatin in a differentiation-dependent but transcription-independent manner.
Topics: Acetylation; Base Sequence; Cell Differentiation; Dimethyl Sulfoxide; DNA; Genes, fos; Genes, myc; Genome, Human; Granulocytes; Heterochromatin; Histone Deacetylase Inhibitors; Histones; Humans; Hydroxamic Acids; Lysine; Molecular Sequence Data; Monocytes; Nucleosomes; Repetitive Sequences, Nucleic Acid; Tetradecanoylphorbol Acetate; Transcription, Genetic; Tumor Cells, Cultured | 1995 |
The acetylation patterns of histones H3 and H4 along Vicia faba chromosomes are different.
Topics: Acetylation; Acetyltransferases; Chromosomes; Enzyme Inhibitors; Fabaceae; Fluorescent Antibody Technique, Indirect; Heterochromatin; Histone Acetyltransferases; Histone Deacetylase Inhibitors; Histones; Hydroxamic Acids; Lysine; Nucleolus Organizer Region; Plants, Medicinal; Repetitive Sequences, Nucleic Acid; Saccharomyces cerevisiae Proteins | 1998 |
Dynamics of histone acetylation in Chlamydomonas reinhardtii.
Topics: Acetates; Acetyl Coenzyme A; Acetylation; Animals; Chlamydomonas reinhardtii; Half-Life; Histone Deacetylase Inhibitors; Histones; Hydroxamic Acids; Kinetics; Lysine; Methylation; Protein Processing, Post-Translational | 1998 |
Molecular mechanism for silencing virally transduced genes involves histone deacetylation and chromatin condensation.
Topics: Acetylation; Adenine Phosphoribosyltransferase; Chromatin; Deoxyribonucleases, Type II Site-Specific; Dependovirus; Gene Expression Regulation; Gene Expression Regulation, Viral; Gene Silencing; Genes, Viral; HeLa Cells; Histocytochemistry; Histones; Humans; Hydroxamic Acids; Lac Operon; Lysine; Precipitin Tests; Transduction, Genetic; Transgenes | 2000 |
The effects of histone acetylation on estrogen responsiveness in MCF-7 cells.
Topics: Acetylation; Cell Line; Drug Synergism; Electrophoresis, Gel, Two-Dimensional; Enzyme Inhibitors; Estradiol; Gene Expression; Histone Deacetylase Inhibitors; Histones; Hydroxamic Acids; In Vitro Techniques; Lysine; Proteins; Receptors, Estrogen; Receptors, Progesterone; RNA, Messenger; Trefoil Factor-1; Tumor Suppressor Proteins | 1999 |
p300 and p300/cAMP-response element-binding protein-associated factor acetylate the androgen receptor at sites governing hormone-dependent transactivation.
Topics: Acetylation; Acetyltransferases; Binding Sites; Cell Cycle Proteins; CREB-Binding Protein; Dihydrotestosterone; Enzyme Inhibitors; Genes, Reporter; Histone Acetyltransferases; Humans; Hydroxamic Acids; Lysine; Mutation; Nuclear Proteins; p300-CBP Transcription Factors; Peptide Fragments; Protein Binding; Receptors, Androgen; Saccharomyces cerevisiae Proteins; Trans-Activators; Transcription Factors; Transcriptional Activation; Tumor Cells, Cultured; Zinc Fingers | 2000 |
Phosphoacetylation of histone H3 on c-fos- and c-jun-associated nucleosomes upon gene activation.
Topics: Acetylation; Animals; Antibodies; Cell Line; Electrophoresis, Polyacrylamide Gel; Genes, Immediate-Early; Histone Deacetylase Inhibitors; Histones; Hydroxamic Acids; Lysine; Mice; Mice, Inbred C3H; Nucleosomes; Phosphopeptides; Phosphorylation; Phosphoserine; Precipitin Tests; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Transcriptional Activation | 2000 |
Methylation of histone H4 at arginine 3 facilitating transcriptional activation by nuclear hormone receptor.
Topics: Acetylation; Amino Acid Sequence; Animals; Arginine; Binding Sites; Cell Nucleus; HeLa Cells; Histones; Humans; Hydroxamic Acids; Intracellular Signaling Peptides and Proteins; Lysine; Methylation; Methyltransferases; Molecular Sequence Data; Mutation; Oocytes; Protein-Arginine N-Methyltransferases; Receptors, Androgen; Recombinant Proteins; S-Adenosylmethionine; Transcriptional Activation; Xenopus | 2001 |
The histone deacetylase inhibitor trichostatin A reduces nickel-induced gene silencing in yeast and mammalian cells.
Topics: Acetylation; Animals; Cell Line; Cricetinae; Enzyme Inhibitors; Fungal Proteins; Gene Silencing; Histone Deacetylase Inhibitors; Hydroxamic Acids; Lysine; Nickel; Protein Structure, Tertiary; Saccharomyces cerevisiae; Time Factors; Transgenes | 2001 |
Acetylation of steroidogenic factor 1 protein regulates its transcriptional activity and recruits the coactivator GCN5.
Topics: Acetylation; Active Transport, Cell Nucleus; Amino Acid Sequence; Animals; Cell Cycle Proteins; COS Cells; DNA-Binding Proteins; Enzyme Inhibitors; Fushi Tarazu Transcription Factors; Histone Acetyltransferases; Homeodomain Proteins; Hydroxamic Acids; Lysine; Molecular Sequence Data; Mutation; p300-CBP Transcription Factors; Receptors, Cytoplasmic and Nuclear; Steroidogenic Factor 1; Trans-Activators; Transcription Factors; Transcription, Genetic; Transcriptional Activation; Zinc Fingers | 2001 |
Inhibition of histone deacetylases alters allelic chromatin conformation at the imprinted U2af1-rs1 locus in mouse embryonic stem cells.
Topics: Acetylation; Alleles; Animals; Blotting, Northern; Blotting, Southern; Cell Differentiation; Cell Nucleus; Chromatin; Deoxyribonuclease I; Deoxyribonucleases; DNA Methylation; Embryo, Mammalian; Enzyme Inhibitors; Female; Fibroblasts; Genomic Imprinting; Histone Deacetylase Inhibitors; Histones; Hydroxamic Acids; Kidney; Lysine; Male; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Nerve Tissue Proteins; Nuclear Proteins; Polymerase Chain Reaction; Polymorphism, Single-Stranded Conformational; Precipitin Tests; Protein Conformation; Proteins; Reverse Transcriptase Polymerase Chain Reaction; Ribonucleoproteins; Splicing Factor U2AF; Stem Cells; Time Factors; Tissue Distribution | 2002 |
Probing lysine acetylation with a modification-specific marker ion using high-performance liquid chromatography/electrospray-mass spectrometry with collision-induced dissociation.
Topics: Acetylation; Amino Acid Sequence; Chromatography, High Pressure Liquid; Cytochrome c Group; HeLa Cells; Histones; Humans; Hydroxamic Acids; Lysine; Molecular Sequence Data; Spectrometry, Mass, Electrospray Ionization | 2002 |
Critical role of histone methylation in tumor suppressor gene silencing in colorectal cancer.
Topics: Adaptor Proteins, Signal Transducing; Azacitidine; Carrier Proteins; Colorectal Neoplasms; Cyclin-Dependent Kinase Inhibitor p16; Decitabine; DNA Methylation; Enzyme Inhibitors; Gene Silencing; Genes, Tumor Suppressor; Histone Deacetylase Inhibitors; Histones; Humans; Hydroxamic Acids; Lysine; Methylation; MutL Protein Homolog 1; Neoplasm Proteins; Nuclear Proteins; O(6)-Methylguanine-DNA Methyltransferase; Precipitin Tests; Promoter Regions, Genetic; Tumor Cells, Cultured | 2003 |
Acetylation of histone H3 at lysine 9 by ethanol in rat hepatocytes.
Topics: Animals; Blotting, Western; Cell Nucleus; Cells, Cultured; Cyanamide; Dose-Response Relationship, Drug; Ethanol; Hepatocytes; Histone Deacetylases; Histones; Hydroxamic Acids; Immunoblotting; Lysine; Protein Synthesis Inhibitors; Rats; Rats, Sprague-Dawley; Time Factors; Transcription, Genetic | 2003 |
Changes in histone acetylation during mouse oocyte meiosis.
Topics: Acetylation; Animals; Cell Nucleus; Chromosomes; Enzyme Inhibitors; Female; Fetus; Gene Expression Regulation, Developmental; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Hydroxamic Acids; Immunohistochemistry; Lysine; Male; Meiosis; Mice; Mice, Inbred ICR; Mitosis; Nuclear Transfer Techniques; Oocytes | 2003 |
Analysis of specific lysine histone H3 and H4 acetylation and methylation status in clones of cells with a gene silenced by nickel exposure.
Topics: Acetylation; Animals; Azacitidine; Bacterial Proteins; Carcinogens; Chromatin; Clone Cells; Cricetinae; Cricetulus; DNA Methylation; Drug Combinations; Escherichia coli Proteins; Gene Expression; Gene Silencing; Histones; Hydroxamic Acids; Lysine; Nickel; Pentosyltransferases; Precipitin Tests; Proteins; RNA, Messenger; Transgenes | 2003 |
Phosphorylation at serine 28 and acetylation at lysine 9 of histone H3 induced by trichostatin A.
Topics: Acetylation; Acetyltransferases; Animals; Enzyme Inhibitors; Histones; Hydroxamic Acids; Lysine; Mice; Mitogen-Activated Protein Kinases; Phosphorylation; Phosphotransferases; Serine | 2003 |
Negative regulation of forkhead transcription factor AFX (Foxo4) by CBP-induced acetylation.
Topics: Animals; Arginine; Blotting, Western; Cell Cycle Proteins; Cell Line; Cell Nucleus; CREB-Binding Protein; Cyclin-Dependent Kinase Inhibitor p27; Forkhead Transcription Factors; Gene Expression Regulation; Glutathione Transferase; Humans; Hydroxamic Acids; Lysine; Models, Genetic; Mutation; Nuclear Proteins; Plasmids; Precipitin Tests; Protein Binding; Recombinant Fusion Proteins; Trans-Activators; Transcription Factors; Transcription, Genetic; Transcriptional Activation; Transfection; Tumor Suppressor Proteins | 2003 |
Induction of PIG3 and NOXA through acetylation of p53 at 320 and 373 lysine residues as a mechanism for apoptotic cell death by histone deacetylase inhibitors.
Topics: Acetylation; Annexin A5; Apoptosis; Butyrates; Carcinoma, Signet Ring Cell; Caspase 3; Caspase Inhibitors; Cell Line, Tumor; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Intracellular Signaling Peptides and Proteins; Lysine; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; RNA, Messenger; Stomach Neoplasms; Transfection; Tumor Suppressor Protein p53 | 2003 |
The androgen receptor acetylation site regulates cAMP and AKT but not ERK-induced activity.
Topics: Acetylation; Animals; Cell Line, Tumor; Cyclic AMP; Enzyme Inhibitors; Gene Expression Regulation; Genes, Reporter; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Hydroxamic Acids; JNK Mitogen-Activated Protein Kinases; Ligands; Lysine; Male; MAP Kinase Signaling System; Mitogen-Activated Protein Kinases; Phosphates; Point Mutation; Prostatic Neoplasms; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Receptors, Androgen; Transcription, Genetic | 2004 |
Transforming growth factor-beta stimulates p300-dependent RUNX3 acetylation, which inhibits ubiquitination-mediated degradation.
Topics: Acetylation; Acetyltransferases; Animals; Cell Cycle Proteins; Cell Line; Core Binding Factor Alpha 3 Subunit; DNA-Binding Proteins; Genes, Reporter; Histone Acetyltransferases; Humans; Hydroxamic Acids; Lysine; p300-CBP Transcription Factors; Protein Processing, Post-Translational; Protein Synthesis Inhibitors; Recombinant Fusion Proteins; Signal Transduction; Transcription Factors; Transcriptional Activation; Transforming Growth Factor beta; Ubiquitin; Ubiquitin-Protein Ligases | 2004 |
Activation of the growth-differentiation factor 11 gene by the histone deacetylase (HDAC) inhibitor trichostatin A and repression by HDAC3.
Topics: Acetylation; Animals; BALB 3T3 Cells; Base Sequence; Bone Morphogenetic Proteins; Cell Line; DNA, Complementary; Enzyme Inhibitors; Gene Expression Regulation; Gene Silencing; Growth Differentiation Factors; HeLa Cells; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Humans; Hydroxamic Acids; Lysine; Mice; Models, Biological; Molecular Sequence Data; Promoter Regions, Genetic; RNA, Messenger; RNA, Small Interfering | 2004 |
ATRX, a member of the SNF2 family of helicase/ATPases, is required for chromosome alignment and meiotic spindle organization in metaphase II stage mouse oocytes.
Topics: Animals; Antibodies, Monoclonal; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calcium-Calmodulin-Dependent Protein Kinases; Cells, Cultured; Chromatin Assembly and Disassembly; Chromosomes; DNA Helicases; Enzyme Inhibitors; Female; Heterochromatin; Histone Deacetylase Inhibitors; Histones; Hydroxamic Acids; Lysine; Meiosis; Metaphase; Mice; Mice, Inbred Strains; Nuclear Proteins; Oocytes; Phosphorylation; Spindle Apparatus; Transcription Factors; X-linked Nuclear Protein | 2004 |
Kinetics and comparative reactivity of human class I and class IIb histone deacetylases.
Topics: Binding Sites; Binding, Competitive; Coumarins; Enzyme Activation; Enzyme Inhibitors; Histone Deacetylase 1; Histone Deacetylase 2; Histone Deacetylase 6; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Hydroxamic Acids; Isoenzymes; Kinetics; Lysine; Phosphorylation; Recombinant Proteins; Repressor Proteins; Substrate Specificity | 2004 |
Histone H4 hyperacetylation precludes histone H4 lysine 20 trimethylation.
Topics: Acetamides; Acetylation; Amino Acid Sequence; Animals; Antineoplastic Agents; Blotting, Western; Butyrates; Cell Differentiation; Cell Line, Tumor; Cell Nucleus; Chromatin; Chromatography, High Pressure Liquid; Chromatography, Liquid; Dimethyl Sulfoxide; Enzyme Inhibitors; Heterochromatin; Histones; Hydroxamic Acids; Leukemia, Erythroblastic, Acute; Lysine; Mass Spectrometry; Metalloendopeptidases; Methylation; Mice; Microscopy, Fluorescence; Molecular Sequence Data; Peptides; Protein Processing, Post-Translational; Sodium Oxybate; Time Factors; Transcription, Genetic | 2004 |
Sumoylation of internally initiated Sp3 isoforms regulates transcriptional repression via a Trichostatin A-insensitive mechanism.
Topics: Amino Acid Substitution; Animals; Blotting, Western; Cell Line; Cell Line, Tumor; Cell Nucleus; Chlorocebus aethiops; COS Cells; DNA-Binding Proteins; Enzyme Inhibitors; Ethylmaleimide; Humans; Hydroxamic Acids; Immunohistochemistry; Lysine; Neoplasm Proteins; Nuclear Proteins; Promoter Regions, Genetic; Promyelocytic Leukemia Protein; Prostate-Specific Antigen; Protein Isoforms; Sp1 Transcription Factor; Sp3 Transcription Factor; SUMO-1 Protein; Tetrahydrofolate Dehydrogenase; Transcription Factors; Transcriptional Activation; Transfection; Tumor Suppressor Proteins; Two-Hybrid System Techniques; Ubiquitin-Conjugating Enzymes | 2005 |
The ESC-E(Z) complex participates in the hedgehog signaling pathway.
Topics: Amino Acid Sequence; Animals; Fish Proteins; Gene Expression Regulation, Developmental; Hedgehog Proteins; Histones; Humans; Hydroxamic Acids; Lysine; Methylation; Molecular Sequence Data; Multiprotein Complexes; Oryzias; Phenotype; Phylogeny; Protein Binding; Sequence Alignment; Signal Transduction; Trans-Activators | 2005 |
Changes in histone modifications during in vitro maturation of porcine oocytes.
Topics: Acetylation; Animals; Cell Cycle; Cells, Cultured; Enzyme Inhibitors; Female; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Hydroxamic Acids; In Vitro Techniques; Lysine; Oocytes; Swine | 2005 |
The essential role of histone H3 Lys9 di-methylation and MeCP2 binding in MGMT silencing with poor DNA methylation of the promoter CpG island.
Topics: Azacitidine; Cell Line, Tumor; Chromosomal Proteins, Non-Histone; CpG Islands; Decitabine; DNA Methylation; DNA-Binding Proteins; Gene Expression; Gene Silencing; Histones; Humans; Hydroxamic Acids; Lysine; Methyl-CpG-Binding Protein 2; O(6)-Methylguanine-DNA Methyltransferase; Polymerase Chain Reaction; Promoter Regions, Genetic; Repressor Proteins; Transcription Factors | 2005 |
The expression of endothelial nitric-oxide synthase is controlled by a cell-specific histone code.
Topics: Acetylation; Animals; Azacitidine; beta-Galactosidase; Blotting, Western; Cell Line; Cell Nucleus; Cells, Cultured; Chromatin; Chromatin Immunoprecipitation; CpG Islands; DNA Methylation; Endothelium, Vascular; HeLa Cells; Histones; Humans; Hydroxamic Acids; Lysine; Methylation; Mice; Mice, Transgenic; Models, Genetic; Muscle, Smooth; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nucleosomes; Promoter Regions, Genetic; Protein Binding; Protein Structure, Tertiary; Reverse Transcriptase Polymerase Chain Reaction; RNA Polymerase II; Serine; Time Factors; Transgenes; Umbilical Veins | 2005 |
Hyperacetylation enhances the growth-inhibitory effect of all-trans retinoic acid by the restoration of retinoic acid receptor beta expression in head and neck squamous carcinoma (HNSCC) cells.
Topics: Acetylation; Antineoplastic Agents; Azacitidine; Carcinoma, Squamous Cell; Cell Line, Tumor; Decitabine; DNA Methylation; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Head and Neck Neoplasms; Histone Deacetylase Inhibitors; Histones; Humans; Hydroxamic Acids; Lysine; Promoter Regions, Genetic; Receptors, Retinoic Acid; Tretinoin | 2005 |
Coordinated changes in DNA methylation and histone modifications regulate silencing/derepression of luteinizing hormone receptor gene transcription.
Topics: Acetylation; Azacitidine; Base Sequence; Chromatin; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Gene Expression Regulation; Gene Silencing; Histone Deacetylase Inhibitors; Histones; Humans; Hydroxamic Acids; Lysine; Molecular Sequence Data; Promoter Regions, Genetic; Receptors, LH; Repressor Proteins; Sin3 Histone Deacetylase and Corepressor Complex; Transcription Factors; Transcription, Genetic; Transcriptional Activation; Tumor Cells, Cultured; Up-Regulation | 2005 |
Histone modification in the TGFbetaRII gene promoter and its significance for responsiveness to HDAC inhibitor in lung cancer cell lines.
Topics: Acetylation; Androstadienes; Azacitidine; Chromatin; DNA Methylation; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Gene Silencing; Histone Deacetylase Inhibitors; Histones; Humans; Hydroxamic Acids; Lung Neoplasms; Lysine; Phosphoinositide-3 Kinase Inhibitors; Promoter Regions, Genetic; Protein Serine-Threonine Kinases; Receptor, Transforming Growth Factor-beta Type II; Receptors, Transforming Growth Factor beta; Signal Transduction; Transcription, Genetic; Tumor Cells, Cultured; Wortmannin | 2005 |
Dynamic acetylation of all lysine 4-methylated histone H3 in the mouse nucleus: analysis at c-fos and c-jun.
Topics: Acetylation; Animals; Cell Nucleus; Cells, Cultured; Enzyme Activation; Histones; Hydroxamic Acids; Lysine; Methylation; Mice; Mitogen-Activated Protein Kinases; Phosphorylation; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Tetradecanoylphorbol Acetate | 2005 |
Inheritable histone H4 acetylation of somatic chromatins in cloned embryos.
Topics: Acetylation; Animals; Cattle; Cells, Cultured; Chromatin; Cloning, Organism; Embryo, Mammalian; Epigenesis, Genetic; Female; Fibroblasts; Gene Expression Regulation, Developmental; Histones; Hydroxamic Acids; Lysine; Protein Synthesis Inhibitors | 2006 |
Acetylation of estrogen receptor alpha by p300 at lysines 266 and 268 enhances the deoxyribonucleic acid binding and transactivation activities of the receptor.
Topics: Acetylation; Amino Acid Sequence; Animals; Binding Sites; Cats; Cell Compartmentation; Cells, Cultured; Conserved Sequence; Cricetinae; DNA; Estrogen Receptor alpha; Estrogen Receptor beta; Estrogens; Humans; Hydroxamic Acids; Lysine; Mass Spectrometry; Mice; Molecular Sequence Data; Niacinamide; Nuclear Receptor Coactivator 2; p300-CBP Transcription Factors; Point Mutation; Protein Structure, Tertiary; Rats; Sequence Alignment; Sirtuins; Transcriptional Activation | 2006 |
Histone deacetylation is required for orderly meiosis.
Topics: Acetylation; Anaphase; Animals; Cell Nucleus; Cells, Cultured; Chromosome Segregation; Gene Expression; Histone Deacetylases; Histones; Hydroxamic Acids; Lysine; Meiosis; Oocytes; Protein Transport; Swine; Telophase | 2006 |
Dynamic and reversible changes in histone H3-Lys4 methylation and H3 acetylation occurring at submergence-inducible genes in rice.
Topics: Acetylation; Chromatin; DNA, Plant; Gene Expression Regulation, Plant; Genes, Plant; Histones; Hydroxamic Acids; Lysine; Methylation; Oryza; Plant Proteins; Protein Synthesis Inhibitors; RNA Polymerase II | 2006 |
Dynamic regulation of histone modifications in Xenopus oocytes through histone exchange.
Topics: Acetylation; Animals; Chromatin; Chromatin Assembly and Disassembly; DNA Replication; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Hydroxamic Acids; Lysine; Methylation; Oocytes; Protein Methyltransferases; Time Factors; Transcription, Genetic; Xenopus laevis | 2006 |
Coordinated recruitment of histone methyltransferase G9a and other chromatin-modifying enzymes in SHP-mediated regulation of hepatic bile acid metabolism.
Topics: Acetylation; Amino Acid Sequence; Animals; Chlorocebus aethiops; Cholesterol 7-alpha-Hydroxylase; Cholic Acid; Chromatin; COS Cells; Gene Expression Regulation; Histone Deacetylase Inhibitors; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; Hydroxamic Acids; Liver; Lysine; Male; Methylation; Mice; Molecular Sequence Data; Promoter Regions, Genetic; Protein Binding; Protein Methyltransferases; Protein Transport; Receptors, Cytoplasmic and Nuclear; Steroid 12-alpha-Hydroxylase; Transcription, Genetic | 2007 |
Diverse histone modifications on histone 3 lysine 9 and their relation to DNA methylation in specifying gene silencing.
Topics: Acetylation; Animals; Azacitidine; Cell Line, Tumor; Chromatin Immunoprecipitation; CpG Islands; Decitabine; DNA Methylation; DNA Modification Methylases; Gene Expression Regulation; Gene Silencing; Histones; Hydroxamic Acids; Leukemia L1210; Lysine; Methylation; Mice; Mice, Inbred DBA; Oligonucleotide Array Sequence Analysis; Protein Processing, Post-Translational | 2007 |
Epidermal stem cells are defined by global histone modifications that are altered by Myc-induced differentiation.
Topics: Animals; Cell Differentiation; Cell Proliferation; Cells, Cultured; Epidermal Cells; Hair Follicle; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Humans; Hydroxamic Acids; Keratinocytes; Lysine; Mice; Mice, Transgenic; Proto-Oncogene Proteins c-myc; Stem Cells | 2007 |
Site-specific acetylation of ISWI by GCN5.
Topics: Acetylation; Adenosine Triphosphatases; Amino Acid Sequence; Animals; Bisbenzimidazole; Cell Line; Drosophila; Drosophila Proteins; Enzyme Inhibitors; Fluorescent Dyes; Gene Deletion; Histone Acetyltransferases; Hydroxamic Acids; Lysine; Molecular Sequence Data; Precipitin Tests; Protein Processing, Post-Translational; Protein Structure, Tertiary; Recombinant Proteins; RNA Interference; Sequence Homology, Amino Acid; Substrate Specificity; Time Factors; Transcription Factors | 2007 |
Dynamic reprogramming of histone acetylation and methylation in the first cell cycle of cloned mouse embryos.
Topics: Acetylation; Animals; Cell Cycle; Cloning, Organism; Embryo, Mammalian; Female; Histone Acetyltransferases; Histone Deacetylase Inhibitors; Histones; Hydroxamic Acids; Lysine; Male; Methylation; Methyltransferases; Mice; Sperm Injections, Intracytoplasmic | 2007 |
Spatial distribution of histone methylation during MHC class II expression.
Topics: Acetylation; Animals; B-Lymphocytes; Cell Line; Gene Expression Regulation; Histocompatibility Antigens Class II; Histone Deacetylases; Histones; Humans; Hydroxamic Acids; Interferon-gamma; Lysine; Methylation; Mice; Nuclear Proteins; Promoter Regions, Genetic; Trans-Activators | 2008 |
Promoter-targeted siRNAs induce gene silencing of simian immunodeficiency virus (SIV) infection in vitro.
Topics: Acetylation; Azacitidine; CD4 Antigens; Cell Line; Chromatin Immunoprecipitation; DNA Methylation; DNA-Cytosine Methylases; Gene Silencing; HeLa Cells; Histones; Humans; Hydroxamic Acids; Lysine; Promoter Regions, Genetic; Receptors, CCR5; Receptors, CXCR4; RNA, Small Interfering; Simian Immunodeficiency Virus | 2008 |
Trichostatin A and nuclear reprogramming of cloned rabbit embryos.
Topics: Acetylation; Animals; Cell Cycle; Cloning, Organism; Embryo, Mammalian; Enzyme Inhibitors; Female; Fertilization in Vitro; Histone Deacetylase Inhibitors; Histones; Hydroxamic Acids; Lysine; Male; Nuclear Transfer Techniques; Rabbits | 2008 |
Carnitine palmitoyltransferase I in human carcinomas: a novel role in histone deacetylation?
Topics: Acetylation; Adenocarcinoma; Aged; Breast Neoplasms; Carnitine O-Palmitoyltransferase; Cell Nucleus; Chromatin Immunoprecipitation; Colorectal Neoplasms; Fatty Acid Synthases; Female; Histone Deacetylase 1; Histone Deacetylase Inhibitors; Histones; Humans; Hydroxamic Acids; Immunohistochemistry; Lysine; Male; Transcription, Genetic | 2007 |
Trichostatin A causes p53 to switch oxidative-damaged colorectal cancer cells from cell cycle arrest into apoptosis.
Topics: Acetylation; Annexin A5; Apoptosis; Cell Cycle; Cell Line, Tumor; Chromatin Immunoprecipitation; Colonic Neoplasms; Cyclin-Dependent Kinase Inhibitor p21; Enzyme Inhibitors; G2 Phase; HCT116 Cells; Histones; Humans; Hydrogen Peroxide; Hydroxamic Acids; Lysine; Mitosis; Models, Biological; Promoter Regions, Genetic; Time Factors; Transcriptional Activation; Tumor Suppressor Protein p53 | 2008 |
Epigenetic modification of histone 3 at lysine 9 in sheep zygotes and its relationship with DNA methylation.
Topics: Animals; Azacitidine; DNA Methylation; Embryo, Mammalian; Epigenesis, Genetic; Female; Fluorescent Antibody Technique; Histones; Hydroxamic Acids; Lysine; Mice; Oocytes; Sheep; Zygote | 2008 |
Changes in acetylation on lysine 12 of histone H4 (acH4K12) of murine oocytes during maternal aging may affect fertilization and subsequent embryo development.
Topics: Acetylation; Aging; Animals; Cell Nucleus; Embryonic Development; Female; Fertilization; Histone Deacetylase Inhibitors; Histones; Hydroxamic Acids; Lysine; Male; Meiosis; Mice; Mice, Inbred Strains; Oocytes; Spindle Apparatus; Superovulation; Zygote | 2010 |
Interaction of TFAP2C with the estrogen receptor-alpha promoter is controlled by chromatin structure.
Topics: Acetylation; Azacitidine; Breast Neoplasms; Cell Line, Tumor; Chromatin; Chromatin Immunoprecipitation; CpG Islands; Decitabine; DNA Methylation; Enzyme Inhibitors; Estrogen Receptor alpha; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Histones; Humans; Hydroxamic Acids; Lysine; Promoter Regions, Genetic; Protein Binding; Reverse Transcriptase Polymerase Chain Reaction; Transcription Factor AP-2 | 2009 |
Dynamic chromatin remodeling events in hippocampal neurons are associated with NMDA receptor-mediated activation of Bdnf gene promoter 1.
Topics: Acetylation; Analysis of Variance; Animals; Azacitidine; Brain-Derived Neurotrophic Factor; Chromatin Assembly and Disassembly; Chromatin Immunoprecipitation; DNA-Binding Proteins; Embryo, Mammalian; Enzyme Inhibitors; Exons; Hippocampus; Histone Deacetylase 1; Histone Deacetylases; Histones; Hydroxamic Acids; In Vitro Techniques; Lysine; Methyl-CpG-Binding Protein 2; Methylation; N-Methylaspartate; Neurons; Promoter Regions, Genetic; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Repressor Proteins; RNA, Messenger; Time Factors; Transcription Factors | 2009 |
Hyperacetylation in prostate cancer induces cell cycle aberrations, chromatin reorganization and altered gene expression profiles.
Topics: Acetylation; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Chromatin; Dose-Response Relationship, Drug; Flow Cytometry; G1 Phase; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Histones; Humans; Hydroxamic Acids; Lysine; Male; Prostatic Neoplasms | 2010 |
Acetylation level of histone H3 in early embryonic stages affects subsequent development of miniature pig somatic cell nuclear transfer embryos.
Topics: Acetylation; Animals; Blastocyst; Dose-Response Relationship, Drug; Embryo, Mammalian; Embryonic Development; Histone Deacetylase Inhibitors; Histones; Hydroxamic Acids; Lysine; Nuclear Transfer Techniques; Protein Processing, Post-Translational; Swine; Swine, Miniature; Time Factors | 2009 |
Trichostatin A affects histone acetylation and gene expression in porcine somatic cell nucleus transfer embryos.
Topics: Acetylation; Animals; Cell Nucleus; Cloning, Organism; Embryo Culture Techniques; Embryo Transfer; Embryo, Mammalian; Embryonic Development; Epigenesis, Genetic; Gene Expression; Histones; Hydroxamic Acids; Lysine; Nuclear Transfer Techniques; Sus scrofa; Transcription Factors | 2009 |
Promoter histone H3 lysine 9 di-methylation is associated with DNA methylation and aberrant expression of p16 in gastric cancer cells.
Topics: Acetylation; Azacitidine; Blotting, Western; Chromatin Immunoprecipitation; Cyclin-Dependent Kinase Inhibitor p16; Decitabine; DNA Methylation; DNA Modification Methylases; DNA, Neoplasm; Enzyme Inhibitors; Gene Silencing; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Humans; Hydroxamic Acids; Immunoprecipitation; Lysine; Polymerase Chain Reaction; Promoter Regions, Genetic; Stomach Neoplasms; Tumor Cells, Cultured | 2009 |
Real-time imaging of histone H4 hyperacetylation in living cells.
Topics: Acetylation; Animals; Chlorocebus aethiops; COS Cells; Enzyme Inhibitors; Fluorescence Resonance Energy Transfer; Green Fluorescent Proteins; HeLa Cells; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Humans; Hydroxamic Acids; Immunoblotting; Lysine; Microscopy, Confocal; Microscopy, Fluorescence; Mitosis; Mutation; Recombinant Fusion Proteins; Time Factors; Transfection | 2009 |
HIPK2 modulates p53 activity towards pro-apoptotic transcription.
Topics: Acetylation; Apoptosis; bcl-2-Associated X Protein; Carrier Proteins; Cell Line, Tumor; Doxorubicin; E1A-Associated p300 Protein; Gene Deletion; Gene Knockdown Techniques; Humans; Hydroxamic Acids; Lysine; Niacinamide; Phosphorylation; Promoter Regions, Genetic; Protein Binding; Protein Serine-Threonine Kinases; Sirtuin 1; Transcription, Genetic; Tumor Suppressor Protein p53; Zinc | 2009 |
Epigenetic regulation of caspase-3 gene expression in rat brain development.
Topics: Age Factors; Animals; Brain; Caspase 3; Cells, Cultured; Chromatin; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation, Developmental; Gene Expression Regulation, Enzymologic; Histone Deacetylase Inhibitors; Histones; Hydroxamic Acids; Lysine; Promoter Regions, Genetic; Rats | 2010 |
Opposing effects of hMOF and SIRT1 on H4K16 acetylation and the sensitivity to the topoisomerase II inhibitor etoposide.
Topics: Acetylation; Animals; Cell Death; Cell Line, Tumor; DNA Damage; Down-Regulation; Drug Resistance, Neoplasm; Enzyme Inhibitors; Etoposide; Histone Acetyltransferases; Histone Deacetylase Inhibitors; Histones; Humans; Hydroxamic Acids; Lysine; Male; Neoplasms; Sirtuin 1; Topoisomerase II Inhibitors; Valproic Acid | 2010 |
Synchronous behaviors of CBP and acetylations of lysine 18 and lysine 23 on histone H3 during porcine oocyte first meiotic division.
Topics: Acetylation; Animals; CREB-Binding Protein; Histones; Hydroxamic Acids; Lysine; Meiosis; Microscopy, Fluorescence; Naphthols; Oocytes; Organophosphates; Subcellular Fractions; Swine | 2010 |
Aberrantly silenced promoters retain a persistent memory of the silenced state after long-term reactivation.
Topics: Adenine Phosphoribosyltransferase; Animals; Azacitidine; Cell Line, Tumor; Chromatin Immunoprecipitation; CpG Islands; Decitabine; DNA Methylation; DNA Modification Methylases; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Histones; Hydroxamic Acids; Lysine; Methylation; Mice; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; Time Factors | 2011 |
In thyroid cancer cell lines expression of periostin gene is controlled by p73 and is not related to epigenetic marks of active transcription.
Topics: Acetylation; Blotting, Western; Cell Adhesion Molecules; Cell Line, Tumor; DNA-Binding Proteins; Epigenomics; Forkhead Transcription Factors; Gene Expression Regulation, Neoplastic; HeLa Cells; Histone Deacetylase Inhibitors; Histones; Humans; Hydroxamic Acids; Lysine; Mutation; Nuclear Proteins; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Thyroid Neoplasms; Transcription Factors; Tumor Protein p73; Tumor Suppressor Proteins | 2011 |
Sumoylation of MEL1S at lysine 568 and its interaction with CtBP facilitates its repressor activity and the blockade of G-CSF-induced myeloid differentiation.
Topics: Bone Marrow; Cell Differentiation; Cell Line; DNA-Binding Proteins; Granulocyte Colony-Stimulating Factor; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Lysine; Sumoylation; Transcription Factors | 2011 |
Dynamic acetylation of all lysine-4 trimethylated histone H3 is evolutionarily conserved and mediated by p300/CBP.
Topics: Acetylation; Animals; Binding Sites; Cell Line; Drosophila; Drosophila Proteins; Evolution, Molecular; Gene Knockdown Techniques; Genes, fos; Genes, Immediate-Early; Genes, jun; Histone Acetyltransferases; Histone Deacetylase Inhibitors; Histones; Humans; Hydroxamic Acids; Lysine; Mice; p300-CBP Transcription Factors; Promoter Regions, Genetic; Species Specificity | 2011 |
Tracking epigenetic histone modifications in single cells using Fab-based live endogenous modification labeling.
Topics: Acetylation; Animals; Antibodies, Monoclonal; Blastocyst; Cells, Cultured; Chromosomes, Human, X; Epigenesis, Genetic; Female; Fluorescence Recovery After Photobleaching; Fluorescent Dyes; Histone Deacetylase Inhibitors; Histones; Humans; Hydroxamic Acids; Immunoglobulin Fab Fragments; Lysine; Male; Methylation; Mice; Microscopy, Confocal; Protein Processing, Post-Translational; Single-Cell Analysis | 2011 |
The acetylation of transcription factor HBP1 by p300/CBP enhances p16INK4A expression.
Topics: Acetylation; Cell Line; Cellular Senescence; CREB-Binding Protein; Cyclin-Dependent Kinase Inhibitor p16; DNA; High Mobility Group Proteins; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Hydroxamic Acids; Lysine; p300-CBP Transcription Factors; Promoter Regions, Genetic; Protein Structure, Tertiary; Repressor Proteins; Transcriptional Activation | 2012 |
Lysine acetylation induced by chronic ethanol consumption impairs dynamin-mediated clathrin-coated vesicle release.
Topics: Acetylation; Alcohol Drinking; Animals; Cell Line, Tumor; Cell Membrane; Cells, Cultured; Clathrin-Coated Vesicles; Dynamins; Ethanol; Exocytosis; Hepatocytes; Histone Deacetylase Inhibitors; Hydroxamic Acids; Lysine; Models, Animal; Rats | 2012 |
Evidence of epigenetic regulation of the tumor suppressor gene cluster flanking RASSF1 in breast cancer cell lines.
Topics: Acetylation; Azacitidine; Breast Neoplasms; Cell Line; Cell Line, Tumor; Chromosomes, Human, Pair 3; Decitabine; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Gene Silencing; Genes, Tumor Suppressor; Histones; Humans; Hydroxamic Acids; Lysine; Multigene Family; Promoter Regions, Genetic; Tumor Suppressor Proteins | 2011 |
Compensatory functions of histone deacetylase 1 (HDAC1) and HDAC2 regulate transcription and apoptosis during mouse oocyte development.
Topics: Acetylation; Animals; Apoptosis; DNA-Binding Proteins; Female; Gene Deletion; Gene Expression Regulation, Developmental; Gene Targeting; Histone Deacetylase 1; Histone Deacetylase 2; Histones; Hydroxamic Acids; Infertility, Female; Jumonji Domain-Containing Histone Demethylases; Lysine; Methylation; Mice; Oocytes; Oogenesis; Organ Size; Ovarian Follicle; RNA Interference; RNA, Messenger; Transcription, Genetic; Transcriptome; Tumor Suppressor Protein p53 | 2012 |
Epigenetic regulation of GATA4 expression by histone modification in AFP-producing gastric adenocarcinoma.
Topics: Adenocarcinoma; alpha-Fetoproteins; Cell Line, Tumor; DNA Methylation; Epigenesis, Genetic; GATA4 Transcription Factor; Gene Expression Regulation, Neoplastic; Gene Silencing; Histone Deacetylase Inhibitors; Histones; Humans; Hydroxamic Acids; Immunohistochemistry; Lysine; Promoter Regions, Genetic; Protein Processing, Post-Translational; Stomach Neoplasms; Transcription, Genetic | 2012 |
Dynamic acetylation of lysine-4-trimethylated histone H3 and H3 variant biology in a simple multicellular eukaryote.
Topics: Acetylation; Amino Acid Substitution; Dictyostelium; Gene Deletion; Gene Expression; Histone-Lysine N-Methyltransferase; Histones; Hydroxamic Acids; Lysine; Methylation | 2012 |
Schizosaccharomyces pombe Hat1 (Kat1) is associated with Mis16 and is required for telomeric silencing.
Topics: Acetylation; Amino Acid Sequence; Carrier Proteins; Gene Deletion; Gene Silencing; Histone Acetyltransferases; Histones; Hydroxamic Acids; Lysine; Molecular Sequence Data; Schizosaccharomyces; Schizosaccharomyces pombe Proteins; Telomere | 2012 |
P300/CBP associated factor regulates nitroglycerin-dependent arterial relaxation by N(ε)-lysine acetylation of contractile proteins.
Topics: Acetylation; Actins; Animals; Aorta; Benzamides; Cyclic GMP; Histone Deacetylase Inhibitors; Hydroxamic Acids; Injections, Subcutaneous; Lysine; Male; Models, Animal; Muscle Contraction; Myocytes, Smooth Muscle; Myosin Light Chains; Nitroglycerin; p300-CBP Transcription Factors; Pyridines; Rats; Valproic Acid; Vasodilation | 2012 |
Epigenetic regulation of CXCR4 expression by the ocular microenvironment.
Topics: Animals; Anterior Chamber; Antimetabolites, Antineoplastic; Azacitidine; Cecum; Cell Line, Tumor; Decitabine; Down-Regulation; Epigenesis, Genetic; Flow Cytometry; Gene Expression; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Hydroxamic Acids; Injections; Injections, Subcutaneous; Lysine; Methylation; Mice; Mice, Inbred BALB C; Neoplasm Transplantation; Promoter Regions, Genetic; Receptors, CXCR4; Reverse Transcriptase Polymerase Chain Reaction; Spleen; Up-Regulation | 2013 |
PSG gene expression is up-regulated by lysine acetylation involving histone and nonhistone proteins.
Topics: Acetylation; Cell Line; Female; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Humans; Hydroxamic Acids; Kruppel-Like Factor 6; Kruppel-Like Transcription Factors; Lysine; p300-CBP Transcription Factors; Placenta; Pregnancy; Pregnancy-Specific beta 1-Glycoproteins; Promoter Regions, Genetic; Proto-Oncogene Proteins; Sp1 Transcription Factor; Transcriptional Activation; Up-Regulation | 2013 |
Enhancement of inflammatory protein expression and nuclear factor Κb (NF-Κb) activity by trichostatin A (TSA) in OP9 preadipocytes.
Topics: Adipocytes; Animals; Cell Differentiation; Chemokine CCL2; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation; Glucose; Histone Deacetylase Inhibitors; Histone Deacetylases; Homeostasis; Hydroxamic Acids; Inflammation; Interleukin-6; Lipopolysaccharides; Lysine; Mice; Palmitic Acid; Stromal Cells; Transcription Factor RelA | 2013 |
Dynamics and regulation of lysine-acetylation during one-cell stage mouse embryos.
Topics: Acetylation; Animals; Female; Fertilization in Vitro; Histone Deacetylase Inhibitors; Hydroxamic Acids; Lysine; Male; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Oocytes; Protein Processing, Post-Translational; Tubulin; Up-Regulation; Zygote | 2013 |
Histone deacetylases inhibitor trichostatin A modulates the extracellular release of APE1/Ref-1.
Topics: Acetylation; Active Transport, Cell Nucleus; DNA-(Apurinic or Apyrimidinic Site) Lyase; Extracellular Space; Green Fluorescent Proteins; HEK293 Cells; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Lysine; Mutagenesis, Site-Directed; Protein Processing, Post-Translational; Recombinant Fusion Proteins | 2013 |
Mechanisms of trichostatin A inhibiting AGS proliferation and identification of lysine-acetylated proteins.
Topics: Acetylation; Antineoplastic Agents; Apoptosis; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Lysine; Neoplasm Proteins; Protein Processing, Post-Translational; Signal Transduction; Stomach Neoplasms; Time Factors | 2013 |
Class I lysine deacetylases facilitate glucocorticoid-induced transcription.
Topics: Acetylation; Amidohydrolases; Animals; Cell Line, Tumor; Dexamethasone; Enzyme Inhibitors; Glucocorticoids; Histones; HSP90 Heat-Shock Proteins; Hydroxamic Acids; Lysine; Mice; Peptides, Cyclic; Protein Binding; Receptors, Glucocorticoid; Transcription, Genetic; Transcriptional Activation; Valproic Acid | 2013 |
Regulation of SIRT2-dependent α-tubulin deacetylation by cellular NAD levels.
Topics: Acetylation; Acrylamides; Enzyme Inhibitors; HEK293 Cells; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Lysine; NAD; Phenanthrenes; Piperidines; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerase Inhibitors; Poly(ADP-ribose) Polymerases; Sirtuin 2; Tubulin | 2014 |
RPL24: a potential therapeutic target whose depletion or acetylation inhibits polysome assembly and cancer cell growth.
Topics: Acetylation; Amino Acid Sequence; Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Eukaryotic Initiation Factors; Gene Expression Regulation, Neoplastic; HEK293 Cells; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Lysine; Mass Spectrometry; Molecular Sequence Data; Polyribosomes; Ribosomal Proteins; RNA Interference | 2014 |
Insights into the lysine acetylproteome of human sperm.
Topics: Acetylation; Acrosome Reaction; Adult; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Hydroxamic Acids; Lysine; Male; Proteome; Sperm Motility; Spermatozoa | 2014 |
Acetylation: a lysine modification with neuroprotective effects in ischemic retinal degeneration.
Topics: Acetylation; Animals; Blotting, Western; Caspase 3; Cell Survival; Electroretinography; Female; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Hydroxamic Acids; Lysine; Male; Neuroprotective Agents; Rats, Inbred BN; Reperfusion Injury; Retinal Degeneration; Retinal Neurons; Valproic Acid | 2014 |
Dual roles of histone H3 lysine 9 acetylation in human embryonic stem cell pluripotency and neural differentiation.
Topics: Acetylation; Animals; Cell Differentiation; Chromatin; Chromatin Immunoprecipitation; Embryonic Stem Cells; Epigenesis, Genetic; Fibroblasts; Histone Deacetylase Inhibitors; Histones; Humans; Hydroxamic Acids; Lysine; Mice; Neurons; p300-CBP Transcription Factors; Pluripotent Stem Cells; Transcription, Genetic | 2015 |
Epigenetic Regulation of Cytosolic Phospholipase A2 in SH-SY5Y Human Neuroblastoma Cells.
Topics: Anacardic Acids; Anilides; Benzamides; Cell Line, Tumor; Chromatin Immunoprecipitation; Deoxyadenosines; Epigenesis, Genetic; Fluorescent Antibody Technique; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Group IV Phospholipases A2; Histone Deacetylase Inhibitors; Histones; Humans; Hydroxamic Acids; L-Lactate Dehydrogenase; Lysine; Neuroblastoma; Pyridines; Real-Time Polymerase Chain Reaction; RNA, Messenger; Thiazoles; Thionucleosides; Valproic Acid | 2016 |
PTEN activation through K163 acetylation by inhibiting HDAC6 contributes to tumour inhibition.
Topics: Acetylation; Animals; Cell Line, Tumor; Cell Membrane; Cell Movement; Cell Proliferation; Enzyme Activation; Gene Expression Regulation, Neoplastic; Histone Deacetylase 6; Histone Deacetylase Inhibitors; Histone Deacetylases; Humans; Hydroxamic Acids; Lysine; Mice; Neoplasm Invasiveness; Protein Transport; PTEN Phosphohydrolase; Vorinostat; Xenograft Model Antitumor Assays | 2016 |
A SUMO-acetyl switch in PXR biology.
Topics: Acetylation; Amino Acid Sequence; Animals; Cell Line; Genes, Reporter; Hepatocytes; Histone Deacetylases; Hydroxamic Acids; Luciferases; Lysine; Male; Mice; Mice, Inbred C57BL; Nuclear Receptor Co-Repressor 2; Pregnane X Receptor; Primary Cell Culture; Protein Processing, Post-Translational; Receptors, Steroid; Sumoylation; Transcriptional Activation; Ubiquitination | 2016 |
Epigenetic modulation on cat-cow interspecies somatic cell nuclear transfer embryos by treatment with trichostatin A.
Topics: Acetylation; Animals; Cats; Cattle; Cellular Reprogramming Techniques; Embryonic Development; Epigenesis, Genetic; Female; Fertilization in Vitro; Histones; Hydroxamic Acids; Lysine; Methylation; Nuclear Transfer Techniques; Species Specificity | 2017 |
Class I histone deacetylases are major histone decrotonylases: evidence for critical and broad function of histone crotonylation in transcription.
Topics: Acetylation; Animals; Cell Line; Gene Expression; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Humans; Hydroxamic Acids; Lysine; Mice; Mutant Proteins; Niacinamide; Sirtuins; Transcription Factors; Transcription, Genetic | 2017 |
TSA increases C/EBP‑α expression by increasing its lysine acetylation in hepatic stellate cells.
Topics: Acetylation; Animals; Apoptosis; Caspases; CCAAT-Enhancer-Binding Protein-alpha; Cell Line, Tumor; Cell Proliferation; Hepatic Stellate Cells; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Lysine; Protein Processing, Post-Translational; Rats; RNA, Messenger | 2017 |
Increased Post-Translational Lysine Acetylation of Myelin Basic Protein Is Associated with Peak Neurological Disability in a Mouse Experimental Autoimmune Encephalomyelitis Model of Multiple Sclerosis.
Topics: Acetylation; Animals; Encephalomyelitis, Autoimmune, Experimental; Histone Deacetylase Inhibitors; Hydroxamic Acids; Lysine; Methylation; Mice; Multiple Sclerosis; Myelin Basic Protein; Nervous System Diseases; Protein Processing, Post-Translational | 2018 |
The stability and antiapoptotic activity of Bm30K-3 can be improved by lysine acetylation in the silkworm, Bombyx mori.
Topics: Acetylation; Animals; Apoptosis; Bombyx; Hydroxamic Acids; Insect Proteins; Larva; Lysine; Proteolysis | 2020 |
Trichostatin A augments esophageal squamous cell carcinoma cells migration by inducing acetylation of RelA at K310 leading epithelia-mesenchymal transition.
Topics: Acetylation; Apoptosis; Biomarkers, Tumor; Cell Movement; Cell Proliferation; Epithelial-Mesenchymal Transition; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Lysine; Transcription Factor RelA; Tumor Cells, Cultured | 2020 |
Alpha Radiation as a Way to Target Heterochromatic and Gamma Radiation-Exposed Breast Cancer Cells.
Topics: Acetylation; Alpha Particles; Breast Neoplasms; Cell Line, Tumor; Cell Survival; Clone Cells; Female; Gamma Rays; Heterochromatin; Histones; Humans; Hydroxamic Acids; Lysine; Neoplastic Stem Cells; Radiation Exposure; Spheroids, Cellular | 2020 |
Lysines Acetylome and Methylome Profiling of H3 and H4 Histones in Trichostatin A-Treated Stem Cells.
Topics: Acetylation; Amino Acid Sequence; Animals; Dimethyl Sulfoxide; Embryonic Stem Cells; Gene Expression Regulation; Histones; Hydroxamic Acids; Lysine; Methylation; Mice; Octamer Transcription Factor-3; Peptides; Peroxiredoxins; Protein Processing, Post-Translational; Proteolysis | 2021 |
Poplar acetylome profiling reveals lysine acetylation dynamics in seasonal bud dormancy release.
Topics: Acetylation; Chimera; Histones; Hydroxamic Acids; Isocitrate Dehydrogenase; Lysine; Plant Proteins; Populus; Protein Processing, Post-Translational; Seasons | 2021 |
IL-1β and TNFα Cooperativity in Regulating IL-6 Expression in Adipocytes Depends on CREB Binding and H3K14 Acetylation.
Topics: 3T3-L1 Cells; Acetylation; Adipocytes; Animals; Base Sequence; Cyclic AMP Response Element-Binding Protein; Gene Expression Regulation; Histones; Humans; Hydroxamic Acids; Interleukin-1beta; Interleukin-6; Lysine; Mice; Promoter Regions, Genetic; Protein Binding; Signal Transduction; Tumor Necrosis Factor-alpha | 2021 |