lysine has been researched along with spermidine in 84 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 32 (38.10) | 18.7374 |
| 1990's | 18 (21.43) | 18.2507 |
| 2000's | 21 (25.00) | 29.6817 |
| 2010's | 7 (8.33) | 24.3611 |
| 2020's | 6 (7.14) | 2.80 |
| Authors | Studies |
|---|---|
| Nezu, J; Oku, A; Sai, Y; Sakamoto, K; Shimane, M; Tamai, I; Tsuji, A; Yabuuchi, H | 1 |
| Baxter, CS; Byvoet, P; Sayre, DF | 1 |
| Pearson, CM; Yu, DT | 1 |
| Cook, GH; Wolff, J | 1 |
| Allen, BL; Clegg, S; Horn, MA; Hornick, DB | 1 |
| Dalla Via, L; Garlid, KD; Siliprandi, D; Toninello, A | 1 |
| Kinzy, TG; Merrick, WC; Park, MH; Wolff, EC | 1 |
| Folk, JE; Hershey, JW; Park, MH; Smit-McBride, Z; Wolff, EC | 1 |
| Khan, NA; Moulinoux, P; Quemener, V | 1 |
| Folk, JE; Park, MH; Wolff, EC | 2 |
| Autuori, F; Farrace, MG; Imparato, M; Piacentini, M; Piredda, L | 1 |
| Park, MH | 3 |
| Igarashi, K; Ito, K | 1 |
| Bernhardt, A; Gerner, EW; Mamont, PS; Siat, M | 1 |
| Gallop, PM; Paz, MA; Torrelio, BM | 2 |
| Hall, DE; Park, LE; Tye, TM; Voigt, MN; Wright, JM | 1 |
| Gordon, ED; Lee, C; Lindquist, SL; Meredith, SC; Mora, R | 1 |
| Bedford, MR; Smith, TK; Summers, JD | 1 |
| Chen, KY; Dou, QP | 1 |
| Abbruzzese, A; Folk, JE; Park, MH | 1 |
| Park, MH; Wolff, EC | 1 |
| Armstrong, B; Berg, S; Cipollo, D; Krogmann, DW | 1 |
| Cohen, SS; Dion, AS | 2 |
| Astrachan, L; Miller, JF | 1 |
| Bode, VC; Harrison, DP | 1 |
| Fillingame, RH; Morris, DR | 1 |
| Inouye, M; Silberstein, S | 1 |
| Filer, D; Kindler, SH; Rosenberg, E | 1 |
| Filer, D; Kindler, SH; Rosenberg, E; Zafriti, D | 1 |
| Cater, DB; Crocker, J | 1 |
| Tabor, CW; Tabor, H | 1 |
| Agam, G; Gartner, TK; Livne, A | 1 |
| Folk, JE; Liberato, DJ; Park, MH; Yergey, AL | 1 |
| Cooper, HL; Folk, JE; Park, MH | 3 |
| Folk, JE; Lee, YB; Park, MH | 1 |
| Folk, JE; Lee, YB; Park, MH; Wolff, EC | 1 |
| Byers, TL; Coward, JK; Lakanen, JR; Pegg, AE | 1 |
| Laube, G; Veh, RW | 1 |
| Chen, KY; Chen, ZP | 1 |
| Joe, YA; Lee, YB; Park, MH; Wolff, EC | 1 |
| Dolence, EK; Dolence, JA; Ghosh, A; Ghosh, M; Miller, MJ; Möllmann, U; Reissbrodt, R | 1 |
| Davies, DR; Liao, DI; Park, MH; Wolff, EC | 1 |
| Bergeron, RJ; McCosar, BH; Müller, R; Smith, RE; Weimar, WR; Yao, H; Zimmerman, CO | 1 |
| Burns, MR; Cai, F; Carlson, CL; Devens, BH; O'Day, CL; Vanderwerf, SM; Webb, HK; Weeks, RS | 1 |
| Lee, CH; Park, MH | 1 |
| Huang, CJ; Moczydlowski, E | 1 |
| Coleman, CS; Pegg, AE | 1 |
| Burns, MR; Cai, F; Carlson, CL; Graminski, GF; Vanderwerf, SM; Webb, HK; Weeks, RS; Ziemer, JR | 1 |
| Aktories, K; Giese, A; Goehring, UM; Lohmann, M; Schirmer, J; Schmalzing, G; Schmidt, G; Uttenweiler-Joseph, S; Wilm, M | 1 |
| Beppu, T; Fukuchi-Shimogori, T; Igarashi, K; Kashiwagi, K; Nishimura, K; Ohki, Y; Saiga, K; Sakata, K; Shirahata, A | 1 |
| Folk, JE; Park, JH; Park, MH; Wolff, EC | 1 |
| Asagoshi, K; Ide, H; Makino, K; Nakano, T; Ohyama, Y; Suzuki, T; Terato, H; Yamada, M | 1 |
| Jing, B; Regen, SL; Zhang, J | 1 |
| Chattopadhyay, MK; Tabor, CW; Tabor, H | 1 |
| Cox, GM; Ganous, TM; Kingsbury, JM; McCusker, JH; Yang, Z | 1 |
| Ceylan, I; El Alaouia, S; Fournet, G; Quash, G; Roch, AM; Simonet, F; Thomas, V | 1 |
| Seidel, ER; Sharpe, JG | 1 |
| Janout, V; Jing, B; Regen, SL | 1 |
| Gonzalez-Esquerra, R; Leeson, S | 1 |
| Kang, KR; Kim, YS; Park, MH; Wolff, EC | 1 |
| Alhonen, L; Cerrada-Gimenez, M; Grigorenko, N; Hyvönen, MT; Jänne, J; Keinänen, TA; Khomutov, AR; Sinervirta, R; Vepsäläinen, J | 1 |
| Blass, JP; Cooper, AJ; Folk, JE; Jeitner, TM; Matson, WR | 1 |
| Chattopadhyay, MK; Park, MH; Tabor, H | 1 |
| Cervantes-Chávez, JA; Ruiz-Herrera, J; Valdés-Santiago, L | 1 |
| Beninati, S; Lentini, A; Melino, S; Provenzano, B; Tabolacci, C | 1 |
| Lu, D; Peterson, LA; Phillips, MB; Sullivan, MM | 1 |
| Alhonen, L; Hyvönen, MT; Keinänen, TA; Khomutov, AR; Khomutov, M; Park, JH; Park, MH; Simonian, A; Vepsäläinen, J | 1 |
| Fairlamb, AH; Jones, DC; Nguyen, S; Phillips, MA; Wyllie, S | 1 |
| Chen, EI; Liu, B; Rieger, R; Sampath, V; Srinivasan, M; Sternglanz, R; Tafrov, S | 1 |
| Corazzari, M; Ippolito, G; Oliverio, S; Piacentini, M; Piredda, L; Sestito, C | 1 |
| Alhonen, L; Hyvönen, MT; Keinänen, TA; Khomutov, AR; Khomutov, M; Kochetkov, SN; Petit, M; Vepsäläinen, J; Weisell, J | 1 |
| Chen, M; Gai, Z; Okada, C; Yao, M; Ye, Y; Yu, J | 1 |
| Amiel, J; Banka, S; Crilly, S; Cross, LA; Cuvertino, S; Davies, SJ; Douglas, AGL; Faundes, V; Fry, AE; Gordon, CT; Granadillo, JL; Harrison, V; Jennings, MD; Kasher, PR; Legraie, S; Lehalle, D; Newkirk, P; Newman, WG; Pavitt, GD; Ranells, J; Saunders, CJ; Splitt, M; Sullivan, BR; Withers, SE | 1 |
| Beuschel, CB; Bogdanow, B; Conrad, TOF; Huang, S; Kintscher, U; Kollipara, L; Liang, Y; Liu, F; Lützkendorf, J; Madeo, F; Maglione, M; Piao, C; See, JCK; Sickmann, A; Sigrist, SJ; Toppe, D | 1 |
| Cook, SA; Diehl, AM; Ho, JP; Pang, J; Petretto, E; Shekeran, SG; Singh, BK; Suzuki, A; Tripathi, M; Widjaja, AA; Yen, PM; Zhou, J | 1 |
| Fadiloglu, EE; Moradi, M; Özogul, F; Rocha, JM; Šimat, V; Yilmaz, N | 1 |
| Bělíček, J; Briozzo, P; Ćavar Zeljković, S; De Diego, N; Frömmel, J; Jagic, F; Kopečná, M; Kopečný, D; Kopečný, DJ; Ľuptáková, E; Moréra, S; Nisler, J; Tarkowski, P; Vigouroux, A | 1 |
4 review(s) available for lysine and spermidine
| Article | Year |
|---|---|
Regulation of amino acid decarboxylation.
Topics: Amino Acids; Animals; Arginine; Biogenic Amines; Carboxy-Lyases; Diamines; Enzyme Activation; Escherichia coli; Glutamates; Histidine; Hydrogen-Ion Concentration; Kidney; Kinetics; Liver; Lysine; Organ Specificity; Ornithine; Pimelic Acids; Putrescine; S-Adenosylmethionine; Spermidine; Spermine | 1974 |
Polyamines.
Topics: Adenosylmethionine Decarboxylase; Animals; Arginase; Aspergillus nidulans; Carboxy-Lyases; Cloning, Molecular; DNA; Escherichia coli; Lysine; Mutation; Neoplasms; Neurospora crassa; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Physarum; Plants; Polyamines; Protein Biosynthesis; Protein Kinases; Protein Processing, Post-Translational; Putrescine; RNA; Saccharomyces cerevisiae; Spermidine; Spermidine Synthase; Spermine; Spermine Synthase | 1984 |
Is hypusine essential for eukaryotic cell proliferation?
Topics: Amino Acid Sequence; Animals; Cell Division; Cell Line; Eukaryotic Translation Initiation Factor 5A; Guanine; Humans; Lysine; Molecular Sequence Data; Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; Protein Precursors; RNA-Binding Proteins; Spermidine | 1993 |
Posttranslational synthesis of hypusine: evolutionary progression and specificity of the hypusine modification.
Topics: Amino Acid Sequence; Animals; Binding Sites; Biological Evolution; Eukaryotic Translation Initiation Factor 5A; Humans; Lysine; Mixed Function Oxygenases; Oxidoreductases Acting on CH-NH Group Donors; Peptide Elongation Factors; Peptide Initiation Factors; Protein Processing, Post-Translational; RNA-Binding Proteins; Sequence Alignment; Spermidine; Substrate Specificity | 2007 |
80 other study(ies) available for lysine and spermidine
| Article | Year |
|---|---|
Novel membrane transporter OCTN1 mediates multispecific, bidirectional, and pH-dependent transport of organic cations.
Topics: Animals; Biological Transport, Active; Carrier Proteins; Cell Line; Gene Expression; Humans; Hydrogen-Ion Concentration; Membrane Potentials; Membrane Proteins; Membrane Transport Proteins; Oocytes; Organic Cation Transport Proteins; Quinidine; RNA, Messenger; Symporters; Tetraethylammonium Compounds; Xenopus laevis | 1999 |
Displacement and aberrant methylation in vitro of H-1 histone in rat liver nuclei after half-saturation of chromatin with polycations.
Topics: Animals; Cations; Cell Nucleus; Chromatin; Histones; Lysine; Methylation; Methyltransferases; Polylysine; Protamines; Rats; S-Adenosylmethionine; Spermidine | 1978 |
Effect of polycations and polyanions on behavior of sheep red blood cell rosettes of human lymphocytes.
Topics: Animals; Antigen-Antibody Reactions; Antilymphocyte Serum; Azides; Cell Membrane; Dextrans; Dinitrophenols; Erythrocytes; Heparin; Humans; Immune Adherence Reaction; Immunologic Techniques; Immunosuppressive Agents; Lymphocytes; Lysine; Neuraminidase; Polymers; Sheep; Sodium; Spermidine; Surface Properties | 1975 |
Charge effects in the activation of adenylate cyclase.
Topics: Adenylyl Cyclases; Animals; Cattle; Cell Membrane; Enzyme Activation; Fluorides; Guanosine Triphosphate; Kinetics; Lysine; Magnesium; Muramidase; Peptides; Potassium Chloride; Prostaglandins E; Ribonucleases; Spermidine; Spermine; Thyroid Gland; Thyrotropin | 1975 |
Adherence to respiratory epithelia by recombinant Escherichia coli expressing Klebsiella pneumoniae type 3 fimbrial gene products.
Topics: Acetates; Acetic Acid; Adhesins, Bacterial; Bacterial Adhesion; Bacterial Proteins; Cheek; Chromosome Mapping; Cloning, Molecular; Epithelium; Escherichia coli; Fimbriae Proteins; Glucose; Humans; Immunoglobulin Fab Fragments; In Vitro Techniques; Klebsiella pneumoniae; Lactose; Lung; Lysine; Microbial Collagenase; Periodic Acid; Polylysine; Protamines; Recombinant Proteins; Spermidine; Spermine; Trachea | 1992 |
Evidence that spermine, spermidine, and putrescine are transported electrophoretically in mitochondria by a specific polyamine uniporter.
Topics: Animals; Biological Transport; Hydrogen-Ion Concentration; Kinetics; Lysine; Membrane Potentials; Mitochondria, Liver; Ornithine; Putrescine; Rats; Spermidine; Spermine; Temperature; Tetraethylammonium; Tetraethylammonium Compounds; Thermodynamics | 1992 |
Two isoforms of eIF-5A in chick embryo. Isolation, activity, and comparison of sequences of the hypusine-containing proteins.
Topics: Amino Acid Sequence; Animals; Cells, Cultured; Chick Embryo; Chickens; Chromatography, DEAE-Cellulose; Chromatography, Gel; Chromatography, Ion Exchange; Electrophoresis, Gel, Two-Dimensional; Eukaryotic Translation Initiation Factor 5A; Fibroblasts; Genetic Variation; Humans; Lysine; Male; Molecular Sequence Data; Peptide Initiation Factors; Peptide Mapping; Putrescine; Rabbits; RNA-Binding Proteins; Sequence Homology, Nucleic Acid; Spermidine; Tritium | 1992 |
Comparison of the activities of variant forms of eIF-4D. The requirement for hypusine or deoxyhypusine.
Topics: Animals; Cadaverine; Cells, Cultured; Chromatography, Ion Exchange; Cricetinae; Eflornithine; Escherichia coli; Eukaryotic Translation Initiation Factor 5A; Humans; Lysine; Molecular Structure; Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; Periodic Acid; Puromycin; RNA-Binding Proteins; Spermidine; Substrate Specificity | 1991 |
Inhibition of adenylate cyclase activity by polyamines in human erythrocyte plasma membranes.
Topics: Adenylyl Cyclase Inhibitors; Arginine; Colforsin; Enzyme Activation; Erythrocyte Membrane; Glutamine; Humans; Lysine; Putrescine; Spermidine; Spermine | 1990 |
Cleavage of spermidine as the first step in deoxyhypusine synthesis. The role of NAD.
Topics: Animals; Chromatography, Gel; Chromatography, Ion Exchange; Eukaryotic Translation Initiation Factor 5A; Kinetics; Lysine; Male; NAD; Oxidation-Reduction; Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; Protein Precursors; Rats; RNA-Binding Proteins; Spermidine; Testis | 1990 |
Polyamine-dependent post-translational modification of proteins in differentiating mouse epidermal cells.
Topics: Animals; Cell Differentiation; Epidermal Cells; Keratinocytes; Lysine; Mice; Mice, Inbred BALB C; Polyamines; Protein Processing, Post-Translational; Spermidine | 1990 |
The essential role of hypusine in eukaryotic translation initiation factor 4D (eIF-4D). Purification of eIF-4D and its precursors and comparison of their activities.
Topics: Animals; Cell Line; Cricetinae; Eflornithine; Eukaryotic Translation Initiation Factor 5A; Isoelectric Point; Lysine; Molecular Weight; Peptide Initiation Factors; Protein Precursors; Protein Processing, Post-Translational; Putrescine; RNA-Binding Proteins; Spermidine; Structure-Activity Relationship | 1989 |
The increase by spermidine of fidelity of protamine synthesis in a wheat-germ cell-free system.
Topics: Arginine; Cell-Free System; Centrifugation, Density Gradient; Cysteine; Histidine; Lysine; Peptide Biosynthesis; Protamines; RNA, Messenger; RNA, Transfer, Amino Acyl; Spermidine; Threonine; Triticum | 1986 |
Post-translational modification of the protein-synthesis initiation factor eIF-4D by spermidine in rat hepatoma cells.
Topics: Animals; Cells, Cultured; Chromatography, High Pressure Liquid; Eflornithine; Eukaryotic Translation Initiation Factor 5A; Liver Neoplasms, Experimental; Lysine; Neoplasm Proteins; Peptide Initiation Factors; Protein Binding; Protein Biosynthesis; Rats; RNA-Binding Proteins; Spermidine; Spermine | 1986 |
The formation and stability of the hypusine containing protein in Chinese hamster ovary cells.
Topics: Animals; Cell Line; Cricetinae; Cricetulus; Eukaryotic Translation Initiation Factor 5A; Female; Lysine; Molecular Weight; Ovary; Peptide Initiation Factors; Putrescine; RNA-Binding Proteins; Spermidine; Spermine | 1987 |
Regulation of biosynthesis of hypusine in Chinese hamster ovary cells. Evidence for eIF-4D precursor polypeptides.
Topics: Animals; Cell Line; Cricetinae; Cricetulus; Cycloheximide; Eflornithine; Female; Fibroblasts; Gene Expression Regulation; Lysine; Ovary; Protein Biosynthesis; Protein Processing, Post-Translational; Spermidine | 1987 |
Influence of avian aflatoxicosis on the synthesis of polyamines.
Topics: Aflatoxins; Animals; Arginase; Arginine; Brain; Chickens; Kidney; Liver; Lysine; Male; Ornithine Decarboxylase; Polyamines; Poultry Diseases; Putrescine; Spermidine; Spermine; Threonine | 1987 |
Eukaryotic initiation factor 4D, the hypusine-containing protein, is conserved among eukaryotes.
Topics: Amino Acids; Animals; Cells; Drosophila melanogaster; Escherichia coli; Eukaryotic Cells; Eukaryotic Translation Initiation Factor 5A; Isoelectric Point; Lysine; Molecular Weight; Peptide Initiation Factors; Peptide Mapping; RNA-Binding Proteins; Saccharomyces cerevisiae; Spermidine | 1987 |
Effect of dietary lysine on polyamine synthesis in the chick.
Topics: Adenosylmethionine Decarboxylase; Amino Acids; Animals; Arginase; Arginine; Chickens; Diet; Kidney; Liver; Lysine; Nutritional Requirements; Ornithine Decarboxylase; Polyamines; Putrescine; Spermidine; Spermine | 1987 |
NAD+ stimulated the spermidine-dependent hypusine formation on the 18 kDa protein in cytosolic lysates derived from NB-15 mouse neuroblastoma cells.
Topics: Animals; Cell Line; Cytosol; Lysine; Mice; Molecular Weight; NAD; Nerve Tissue Proteins; Neuroblastoma; Putrescine; Spermidine; Tritium | 1988 |
The identification of an eukaryotic initiation factor 4D precursor in spermidine-depleted Chinese hamster ovary cells.
Topics: Animals; Cell Line; Cricetinae; Cricetulus; Eukaryotic Translation Initiation Factor 5A; Female; Isoelectric Point; Lysine; Ovary; Peptide Initiation Factors; Peptide Mapping; Protein Precursors; Protein Processing, Post-Translational; RNA-Binding Proteins; Spermidine | 1988 |
Post-translational formation of hypusine: biogenesis of translation initiation factor eIF-4D.
Topics: Animals; Eukaryotic Initiation Factor-4F; Gene Expression Regulation; Lysine; Peptide Initiation Factors; Protein Processing, Post-Translational; Putrescine; Spermidine | 1988 |
Cell-free synthesis of deoxyhypusine. Separation of protein substrate and enzyme and identification of 1,3-diaminopropane as a product of spermidine cleavage.
Topics: Animals; Cell Line; Cell-Free System; Chromatography, Ion Exchange; Cricetinae; Diamines; Eflornithine; Eukaryotic Translation Initiation Factor 5A; Lysine; NAD; Peptide Initiation Factors; RNA-Binding Proteins; Spermidine | 1988 |
Polycation inhibition of chloroplast photosystem I.
Topics: Amines; Biological Transport; Cell Membrane; Chloroplasts; Cytochrome c Group; Detergents; Histones; Lysine; Molecular Weight; Muramidase; Palmitic Acids; Peptides; Phosphatidylcholines; Photophosphorylation; Photosynthesis; Polymers; Ribonucleases; Species Specificity; Spermidine; Spermine; Triglycerides; Trypsin | 1973 |
Polyamine stimulation of nucleic acid synthesis in an uninfected and phage-infected polyamine auxotroph of Escherichia coli K12 (arginine-agmatine ureohydrolase-putrescine-spermidine-lysine-cadaverine).
Topics: Amines; Arginine; Chromatography, Thin Layer; Coliphages; Culture Media; DNA, Bacterial; DNA, Viral; Escherichia coli; Guanidines; Lysine; Mutation; Nucleic Acids; Polyamines; Propylamines; Putrescine; Spermidine; Stimulation, Chemical; Ureohydrolases | 1972 |
Polyamines in the synthesis of bacteriophage deoxyribonucleic acid. II. Requirement for polyamines in T4 infection of a polyamine auxotroph.
Topics: Arginine; Canavanine; Carbon Isotopes; Coliphages; Culture Media; Dansyl Compounds; DNA, Bacterial; DNA, Viral; Escherichia coli; Genetics, Microbial; Hydrogen-Ion Concentration; Lysine; Micropore Filters; Mutation; Polyamines; Putrescine; RNA, Bacterial; Spermidine; Urease | 1972 |
Cadaverine in bacteriophage T4.
Topics: Aerobiosis; Anaerobiosis; Cadaverine; Carbon Isotopes; Carboxy-Lyases; Chromatography; Coliphages; Culture Media; DNA Viruses; Enzyme Induction; Escherichia coli; Lysine; Polyamines; Putrescine; Spermidine; Virus Replication | 1973 |
Distinct effects of diamines, polyamines, and magnesium ions on the stability of lambda phage heads.
Topics: Cadaverine; Calcium; Coliphages; DNA, Viral; Drug Stability; Escherichia coli; Lysine; Magnesium; Mutation; Nucleic Acid Conformation; Ornithine; Polyamines; Propylamines; Putrescine; Spermidine; Spermine; Thymidine; Tritium; Viral Proteins | 1973 |
The effects of lysozyme on DNA--membrane association in Escherichia coli.
Topics: Binding Sites; Carbon Radioisotopes; Cell Membrane; Centrifugation, Density Gradient; Chromosomes, Bacterial; Coliphages; Deoxycholic Acid; DNA Viruses; DNA, Bacterial; Egg White; Escherichia coli; Isotope Labeling; Lysine; Magnesium; Muramidase; Peptides; Polyethylene Glycols; Protein Binding; Spermidine; Sulfur Radioisotopes; Thymidine; Time Factors | 1974 |
Aspartokinase of Myxococcus xanthus: "feedback stimulation" by required amino acids.
Topics: Aspartic Acid; Autoradiography; Bacteria; Bacterial Proteins; Carbon Isotopes; Cell-Free System; Chromatography, Paper; Enzyme Activation; Enzyme Repression; Feedback; Isoleucine; Lysine; Methionine; Phosphotransferases; Spectrophotometry; Spermidine; Stereoisomerism; Threonine | 1973 |
Aspartokinase activity and the developmental cycle of Myxococcus xanthus.
Topics: Agar; Bacteria; Chromatography, Paper; Feedback; Glycerol; Isoleucine; Lysine; Methionine; Mutation; Phosphotransferases; Pimelic Acids; Spermidine; Spores, Bacterial; Stereoisomerism; Threonine | 1973 |
In-vitro and in-vivo adherence of allergised lymph-node cells to BP8 ascites tumour cells, in the presence of polyamines and quarternary ammonium compounds.
Topics: Animals; Arginine; Bis-Trimethylammonium Compounds; Cell Adhesion; Freund's Adjuvant; Histamine; Immunization; Lymph Nodes; Lymphocytes; Lysine; Mice; Mice, Inbred C3H; Neoplasms, Experimental; p-Methoxy-N-methylphenethylamine; Pentolinium Tartrate; Polyamines; Quaternary Ammonium Compounds; Spermidine; Spermine | 1973 |
Inhibition of platelet aggregation and endogenous lectin activity by oligoamines.
Topics: Amino Acids; Animals; Cattle; Dose-Response Relationship, Drug; Hemagglutination Tests; Histidine; Humans; Lectins; Lysine; Ornithine; Platelet Aggregation; Putrescine; Serotonin; Spermidine; Spermine; Thrombin | 1984 |
Cellular proliferation and hypusine synthesis.
Topics: Animals; Cell Division; Cell Line; Cricetinae; Cricetulus; Culture Media; DNA; Female; Fibroblasts; Humans; Kinetics; Lysine; Ovary; Polyamines; Protein Biosynthesis; Putrescine; Spermidine; Spermine | 1984 |
The biosynthesis of hypusine (N epsilon-(4-amino-2-hydroxybutyl)lysine). Alignment of the butylamine segment and source of the secondary amino nitrogen.
Topics: Animals; Butylamines; Cell Line; Chromatography, High Pressure Liquid; Cricetinae; Cricetulus; Female; Isotope Labeling; Lysine; Mass Spectrometry; Putrescine; Spermidine | 1984 |
Hypusine formation: a unique posttranslational modification in translation initiation factor eIF-4D.
Topics: Animals; Chromatography, Ion Exchange; Eukaryotic Translation Initiation Factor 5A; Humans; Lymphocytes; Lysine; Peptide Initiation Factors; Protein Processing, Post-Translational; Rabbits; Radioisotope Dilution Technique; Reticulocytes; RNA-Binding Proteins; Spermidine; Tritium | 1984 |
Identification of hypusine, an unusual amino acid, in a protein from human lymphocytes and of spermidine as its biosynthetic precursor.
Topics: Blood Proteins; Chromatography, Ion Exchange; Chromatography, Thin Layer; Electrophoresis, Polyacrylamide Gel; Humans; Lymphocytes; Lysine; Spermidine | 1981 |
The biosynthesis of protein-bound hypusine (N epsilon -(4-amino-2-hydroxybutyl)lysine). Lysine as the amino acid precursor and the intermediate role of deoxyhypusine (N epsilon -(4-aminobutyl)lysine).
Topics: Animals; Cell Line; Cricetinae; Cricetulus; Female; Kinetics; Lysine; Ovary; Putrescine; Radioisotope Dilution Technique; Spermidine; Tritium | 1982 |
Diamine and triamine analogs and derivatives as inhibitors of deoxyhypusine synthase: synthesis and biological activity.
Topics: Animals; Binding, Competitive; Cell Division; CHO Cells; Cricetinae; Cricetulus; Diamines; Eukaryotic Translation Initiation Factor 5A; Humans; Lysine; Male; Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; Polyamines; Rats; RNA-Binding Proteins; Spermidine; Structure-Activity Relationship; Testis | 1995 |
Antiproliferative effects of inhibitors of deoxyhypusine synthase. Inhibition of growth of Chinese hamster ovary cells by guanyl diamines.
Topics: Animals; Cell Division; Cell Survival; CHO Cells; Cricetinae; Diamines; Dose-Response Relationship, Drug; Guanine; Indicators and Reagents; Kinetics; Lysine; Oxidoreductases Acting on CH-NH Group Donors; Polyamines; Protein Biosynthesis; Putrescine; Spermidine; Spermine; Structure-Activity Relationship | 1994 |
The role of hypusine depletion in cytostasis induced by S-adenosyl-L-methionine decarboxylase inhibition: new evidence provided by 1-methylspermidine and 1,12-dimethylspermine.
Topics: Adenosylmethionine Decarboxylase; Animals; Cell Division; CHO Cells; Chromatography, High Pressure Liquid; Cricetinae; Deoxyadenosines; Eflornithine; Eukaryotic Translation Initiation Factor 5A; Leukemia L1210; Lysine; Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; RNA-Binding Proteins; Spermidine; Spermine; Substrate Specificity; Tumor Cells, Cultured | 1994 |
Astrocytes, not neurons, show most prominent staining for spermidine/spermine-like immunoreactivity in adult rat brain.
Topics: Animals; Antibody Specificity; Arginine; Astrocytes; Brain; Brain Chemistry; Enzyme-Linked Immunosorbent Assay; Ethanolamine; Ethanolamines; Female; Histamine; Immunohistochemistry; Lysine; Male; Neurons; Ornithine; Putrescine; Rats; Rats, Inbred Lew; Spermidine | 1997 |
Marked elevation of hypusine formation activity on eukaryotic initiation factor 5A in v-HA-RAS transformed mouse NIH3T3 cells.
Topics: 3T3 Cells; Animals; Cell Transformation, Neoplastic; Eflornithine; Eukaryotic Translation Initiation Factor 5A; Gene Expression; Lysine; Mice; Oncogene Protein p21(ras); Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; RNA-Binding Proteins; Spermidine | 1997 |
Enzyme-substrate intermediate at a specific lysine residue is required for deoxyhypusine synthesis. The role of Lys329 in human deoxyhypusine synthase.
Topics: Biopolymers; Humans; Lysine; Mutagenesis, Site-Directed; Oxidoreductases Acting on CH-NH Group Donors; Spermidine; Substrate Specificity | 1997 |
Selective growth promotion and growth inhibition of gram-negative and gram-positive bacteria by synthetic siderophore-beta-lactam conjugates.
Topics: Bacterial Outer Membrane Proteins; Bacterial Proteins; Biological Transport, Active; Catechols; Cephalosporins; Depression, Chemical; Escherichia coli Proteins; Gram-Negative Bacteria; Gram-Positive Bacteria; Hydroxamic Acids; Iron; Lysine; Membrane Proteins; Mycobacterium; Siderophores; Spermidine; Stimulation, Chemical; Triazines | 1998 |
Crystal structure of the NAD complex of human deoxyhypusine synthase: an enzyme with a ball-and-chain mechanism for blocking the active site.
Topics: Binding Sites; Crystallography, X-Ray; Humans; Hydrogen Bonding; Lysine; Models, Molecular; NAD; Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; Protein Conformation; Protein Processing, Post-Translational; Protein Structure, Secondary; Recombinant Proteins; Spermidine | 1998 |
Effect of polyamine analogues on hypusine content in JURKAT T-cells.
Topics: Adenosylmethionine Decarboxylase; Animals; Antineoplastic Agents; Biological Transport; Cell Division; Chromatography, High Pressure Liquid; Dansyl Compounds; Enzyme Inhibitors; Humans; Jurkat Cells; Leukemia L1210; Lysine; Ornithine Decarboxylase Inhibitors; Spermidine; Spermine; Tumor Cells, Cultured | 1998 |
Novel lysine-spermine conjugate inhibits polyamine transport and inhibits cell growth when given with DFMO.
Topics: Animals; Antineoplastic Agents; Biological Transport; Breast Neoplasms; Cell Division; Eflornithine; Female; Humans; Indicators and Reagents; Kinetics; Lysine; Male; Melanoma; Mice; Mice, Nude; Molecular Structure; Polyamines; Prostatic Neoplasms; Spermidine; Spermine; Tumor Cells, Cultured; Urinary Bladder Neoplasms; Xenograft Model Antitumor Assays | 2000 |
Human deoxyhypusine synthase: interrelationship between binding of NAD and substrates.
Topics: Binding Sites; Eukaryotic Initiation Factor-5; Humans; Hydrogen-Ion Concentration; Lysine; NAD; Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; Protein Binding; Protein Precursors; Spermidine; Substrate Specificity; Time Factors | 2000 |
Cytoplasmic polyamines as permeant blockers and modulators of the voltage-gated sodium channel.
Topics: Amino Acid Substitution; Animals; Binding Sites; Cell Line; Cytoplasm; Heparin; Humans; Ion Channel Gating; Kinetics; Lysine; Membrane Potentials; Models, Biological; Muscle, Skeletal; Mutagenesis, Site-Directed; Rats; Recombinant Proteins; Sodium Channels; Spermidine; Spermine; Transfection | 2001 |
Polyamine analogues inhibit the ubiquitination of spermidine/spermine N1-acetyltransferase and prevent its targeting to the proteasome for degradation.
Topics: Acetyltransferases; Animals; Arginine; Binding Sites; Cysteine Endopeptidases; DNA, Complementary; Dose-Response Relationship, Drug; Lysine; Multienzyme Complexes; Mutation; Plasmids; Polyamines; Proteasome Endopeptidase Complex; Protein Binding; Protein Conformation; Rabbits; Rats; Reticulocytes; Spermidine; Spermine; Time Factors; Ubiquitins | 2001 |
Amino acid/spermine conjugates: polyamine amides as potent spermidine uptake inhibitors.
Topics: Amino Acids; Antineoplastic Agents; Biological Transport; Drug Interactions; Drug Screening Assays, Antitumor; Eflornithine; Humans; Lysine; Ornithine Decarboxylase Inhibitors; Putrescine; Spermidine; Spermine; Structure-Activity Relationship; Tumor Cells, Cultured | 2001 |
Lysine and polyamines are substrates for transglutamination of Rho by the Bordetella dermonecrotic toxin.
Topics: Animals; Bacterial Toxins; Bordetella; Cross-Linking Reagents; Lysine; Microinjections; Oocytes; Polyamines; Putrescine; Recombinant Fusion Proteins; rho GTP-Binding Proteins; rhoA GTP-Binding Protein; Spermidine; Substrate Specificity; Transglutaminases; Virulence Factors, Bordetella; Xenopus | 2001 |
Inhibition of cell growth through inactivation of eukaryotic translation initiation factor 5A (eIF5A) by deoxyspergualin.
Topics: Animals; Antibiotics, Antineoplastic; Eukaryotic Translation Initiation Factor 5A; Female; Guanidines; Lysine; Mice; Models, Chemical; Peptide Initiation Factors; Putrescine; RNA Caps; RNA-Binding Proteins; RNA, Messenger; Spermidine; Structure-Activity Relationship; Tumor Cells, Cultured | 2002 |
Reversal of the deoxyhypusine synthesis reaction. Generation of spermidine or homospermidine from deoxyhypusine by deoxyhypusine synthase.
Topics: Eukaryotic Translation Initiation Factor 5A; Humans; Hydrogen-Ion Concentration; Kinetics; Lysine; Models, Chemical; NAD; Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; Putrescine; RNA-Binding Proteins; Spermidine; Time Factors; Trichloroacetic Acid | 2003 |
Adduct formation between oxanine and amine derivatives.
Topics: Amines; DNA Adducts; Lysine; Purine Nucleosides; Spermidine | 2001 |
Kinetic evidence for the existence and mechanism of formation of a barrel stave structure from pore-forming dendrimers.
Topics: Cholic Acid; Glutathione; Kinetics; Lipid Bilayers; Liposomes; Lysine; Phosphatidylcholines; Polyamines; Sodium; Spermidine; Spermine; Structure-Activity Relationship | 2003 |
Spermidine but not spermine is essential for hypusine biosynthesis and growth in Saccharomyces cerevisiae: spermine is converted to spermidine in vivo by the FMS1-amine oxidase.
Topics: Base Sequence; DNA, Fungal; Eukaryotic Translation Initiation Factor 5A; Genes, Fungal; Kinetics; Lysine; Mutation; Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; Polyamine Oxidase; RNA-Binding Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Spermidine; Spermine; Substrate Specificity | 2003 |
Novel chimeric spermidine synthase-saccharopine dehydrogenase gene (SPE3-LYS9) in the human pathogen Cryptococcus neoformans.
Topics: Cell Proliferation; Cloning, Molecular; Cryptococcosis; Cryptococcus neoformans; Gene Expression Regulation, Fungal; Genes, Fungal; Humans; Lysine; Melanins; Mutation; Recombinant Fusion Proteins; Saccharomyces cerevisiae; Saccharopine Dehydrogenases; Spermidine; Spermidine Synthase | 2004 |
Definition of the fine specificity of the monoclonal antibody 81D4: its reactivity with lysine and polyamine isopeptide cross-links.
Topics: Animals; Antibodies, Monoclonal; Antibody Specificity; Fibrin Fibrinogen Degradation Products; Humans; Immunoenzyme Techniques; Lysine; Mice; Putrescine; Spermidine | 2004 |
Polyamines are absorbed through a y+ amino acid carrier in rat intestinal epithelial cells.
Topics: Absorption; Animals; Cationic Amino Acid Transporter 1; Cell Line; CHO Cells; Cricetinae; Epithelial Cells; Ethylmaleimide; Intestinal Mucosa; Lysine; Mice; Polyamines; Putrescine; Rats; Spermidine | 2005 |
Molecular umbrella-assisted transport of an oligonucleotide across cholesterol-rich phospholipid bilayers.
Topics: Biological Transport; Cholesterol; Cholic Acid; Deoxycholic Acid; Lipid Bilayers; Liposomes; Lysine; Models, Molecular; Nitrobenzoates; Oligonucleotides; Phosphatidylcholines; Phosphatidylglycerols; Phospholipids; Spermidine; Structure-Activity Relationship; Sulfhydryl Compounds | 2005 |
Concentrations of putrescine, spermidine, and spermine in duodenum and pancreas as affected by the ratio of arginine to lysine and source of methionine in broilers under heat stress.
Topics: Age Factors; Animal Feed; Animal Nutritional Physiological Phenomena; Animals; Arginine; Chickens; Dose-Response Relationship, Drug; Duodenum; Heat Stress Disorders; Hot Temperature; Lysine; Male; Methionine; Nutritional Requirements; Pancreas; Poultry Diseases; Putrescine; Random Allocation; Spermidine; Spermine; Weight Gain | 2006 |
Role of hypusinated eukaryotic translation initiation factor 5A in polyamine depletion-induced cytostasis.
Topics: alpha-Amylases; Animals; Animals, Genetically Modified; Cell Proliferation; Eflornithine; Eukaryotic Translation Initiation Factor 5A; Humans; Kinetics; Lysine; Models, Biological; Pancreatitis; Peptide Initiation Factors; Polyamines; Rats; Recombinant Proteins; RNA-Binding Proteins; Spermidine; Stereoisomerism | 2007 |
Increased levels of gamma-glutamylamines in Huntington disease CSF.
Topics: Adult; Aged; Aged, 80 and over; Amination; Biogenic Polyamines; Biomarkers; Brain; Female; Glutamine; Humans; Huntington Disease; Lysine; Male; Middle Aged; Neurochemistry; Protein Processing, Post-Translational; Putrescine; Spermidine; Transglutaminases; Up-Regulation | 2008 |
Hypusine modification for growth is the major function of spermidine in Saccharomyces cerevisiae polyamine auxotrophs grown in limiting spermidine.
Topics: Eukaryotic Translation Initiation Factor 5A; Intracellular Space; Lysine; Peptide Initiation Factors; RNA-Binding Proteins; Saccharomyces cerevisiae; Spermidine; Tritium | 2008 |
Ustilago maydis spermidine synthase is encoded by a chimeric gene, required for morphogenesis, and indispensable for survival in the host.
Topics: DNA, Fungal; Gene Deletion; Gene Expression Profiling; Gene Expression Regulation, Fungal; Genes, Fungal; Genetic Complementation Test; Lysine; Microbial Viability; Molecular Sequence Data; Plant Diseases; Putrescine; Recombination, Genetic; Saccharopine Dehydrogenases; Sequence Analysis, DNA; Spermidine; Spermidine Synthase; Ustilago; Zea mays | 2009 |
Post-translational modification of glutamine and lysine residues of HIV-1 aspartyl protease by transglutaminase increases its catalytic activity.
Topics: Animals; Aspartic Acid Proteases; Catalysis; Enzyme Activation; Factor XIIIa; Glutamine; Guinea Pigs; HIV-1; Humans; Liver; Lysine; Protein Processing, Post-Translational; Spermidine; Transglutaminases | 2010 |
Polyamines are traps for reactive intermediates in furan metabolism.
Topics: Acetylcysteine; Aldehydes; Animals; Biotransformation; Carcinogens; Chromatography, High Pressure Liquid; Cytochrome P-450 Enzyme System; Environmental Pollution; Furans; Glutamine; Glutathione; Hepatocytes; Humans; Liver; Lysine; Mass Spectrometry; Ornithine; Oxidation-Reduction; Putrescine; Pyrroles; Rats; Spermidine | 2011 |
Effects of novel C-methylated spermidine analogs on cell growth via hypusination of eukaryotic translation initiation factor 5A.
Topics: Blotting, Western; Cell Division; Cell Line, Tumor; Eukaryotic Translation Initiation Factor 5A; Humans; Lysine; Male; Methylation; Peptide Initiation Factors; RNA-Binding Proteins; Spermidine | 2012 |
Allosteric activation of trypanosomatid deoxyhypusine synthase by a catalytically dead paralog.
Topics: Animals; Cattle; Escherichia coli; Gene Knockdown Techniques; Humans; Lysine; Mice; Oxidoreductases Acting on CH-NH Group Donors; Protozoan Proteins; Recombinant Proteins; Spermidine; Trypanosoma brucei brucei; Trypanosomiasis, Bovine | 2013 |
Biochemical characterization of Hpa2 and Hpa3, two small closely related acetyltransferases from Saccharomyces cerevisiae.
Topics: Acetylation; Acetyltransferases; Amino Acid Sequence; Amino Acids; Amino-Acid N-Acetyltransferase; Codon, Initiator; Electrophoresis, Polyacrylamide Gel; High Mobility Group Proteins; Histone Acetyltransferases; Histones; Isoenzymes; Lysine; Methionine; Molecular Sequence Data; Mutation; Protein Multimerization; Putrescine; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sequence Homology, Amino Acid; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Spermidine; Spermine; Substrate Specificity | 2013 |
The spermidine analogue GC7 (N1-guanyl-1,7-diamineoheptane) induces autophagy through a mechanism not involving the hypusination of eIF5A.
Topics: Autophagy; Cell Line, Tumor; Eukaryotic Translation Initiation Factor 5A; Fibrosarcoma; Humans; Lysine; Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; Protein Processing, Post-Translational; RNA-Binding Proteins; Spermidine | 2014 |
Enantiomers of 3-methylspermidine selectively modulate deoxyhypusine synthesis and reveal important determinants for spermidine transport.
Topics: Biological Transport; Cell Line, Tumor; Eflornithine; Eukaryotic Translation Initiation Factor 5A; Gene Expression; Humans; Lysine; Male; Ornithine Decarboxylase Inhibitors; Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; Protein Processing, Post-Translational; RNA-Binding Proteins; Spermidine; Stereoisomerism; Substrate Specificity | 2015 |
Flexible NAD
Topics: Binding Sites; Crystallography, X-Ray; Eukaryota; Lysine; NAD; Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; Protein Conformation; Protein Processing, Post-Translational; Pyrococcus horikoshii; Spermidine | 2020 |
Impaired eIF5A function causes a Mendelian disorder that is partially rescued in model systems by spermidine.
Topics: Adolescent; Amino Acid Sequence; Animals; Child; Developmental Disabilities; Embryo, Nonmammalian; Eukaryotic Translation Initiation Factor 5A; Female; Gene Expression Regulation, Developmental; Humans; Lysine; Male; Microcephaly; Micrognathism; Peptide Initiation Factors; Peptides; Protein Biosynthesis; Protein Conformation; Protein Isoforms; Ribosomes; RNA-Binding Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sequence Alignment; Sequence Homology, Amino Acid; Spermidine; Zebrafish; Zebrafish Proteins | 2021 |
eIF5A hypusination, boosted by dietary spermidine, protects from premature brain aging and mitochondrial dysfunction.
Topics: Administration, Oral; Aging, Premature; Animals; Brain; Cell Respiration; Drosophila melanogaster; Drosophila Proteins; Eukaryotic Translation Initiation Factor 5A; Gene Expression Profiling; Gene Expression Regulation, Developmental; Humans; Locomotion; Lysine; Memory; Mitochondria; Mitochondrial Proteins; Models, Animal; Neurons; Peptide Initiation Factors; Protein Processing, Post-Translational; RNA-Binding Proteins; Spermidine | 2021 |
Spermidine-mediated hypusination of translation factor EIF5A improves mitochondrial fatty acid oxidation and prevents non-alcoholic steatohepatitis progression.
Topics: Animals; Fatty Acids; Lysine; Mice; Mitochondria; Non-alcoholic Fatty Liver Disease; Peptide Initiation Factors; Spermidine | 2022 |
Reduction of biogenic amines formation by foodborne pathogens using postbiotics in lysine-decarboxylase broth.
Topics: Agmatine; Ammonia; Biogenic Amines; Butyrates; Cadaverine; Carboxy-Lyases; Escherichia coli; Lactococcus lactis; Lysine; Putrescine; Spermidine; Spermine | 2022 |
Biochemical and structural basis of polyamine, lysine and ornithine acetylation catalyzed by spermine/spermidine N-acetyl transferase in moss and maize.
Topics: Acetylation; Acetyltransferases; Animals; Catalysis; Humans; Lysine; Mammals; Ornithine; Polyamines; Spermidine; Spermine; Zea mays | 2023 |