lysine has been researched along with methotrexate in 16 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (37.50) | 18.7374 |
| 1990's | 4 (25.00) | 18.2507 |
| 2000's | 3 (18.75) | 29.6817 |
| 2010's | 2 (12.50) | 24.3611 |
| 2020's | 1 (6.25) | 2.80 |
| Authors | Studies |
|---|---|
| Amiel, JL; Droz, JP; Tursz, T | 1 |
| Chan, PK | 1 |
| Freisheim, JH; Hynes, JB; Jansen, G; Kerwar, SS; McAlinden, TP; Patil, SA; Schornagel, JH; Westerhof, GR | 1 |
| Freisheim, JH; Thompson, PD | 1 |
| Freisheim, JH; Kumar, AA | 1 |
| Delcamp, TJ; Freisheim, JH; Kumar, AA; Price, EM; Smith, PL; Susten, SS | 1 |
| Baccanari, DP; Delcamp, TJ; Forsch, RA; Freisheim, JH; Rosowsky, A; Solan, VC | 1 |
| Anstead, GM; Freisheim, JH; Kempton, RJ; Kumar, AA; Price, EM | 1 |
| Assaraf, YG; Goldman, ID; Zhao, R | 1 |
| Babani, S; Goldman, ID; Sharina, IG; Wang, Y; Zhao, R | 1 |
| SCHULMAN, MP; SNYDER, R; VOGEL, WH | 1 |
| Kageyama, Y; Nagafusa, T; Nagano, A; Takahashi, M; Torikai, E | 1 |
| Cherian, C; Deng, Y; Gangjee, A; Hou, Z; Matherly, LH; Wang, L; Wu, J | 1 |
| Infante, MR; Mitjans, M; Nogueira, DR; Pérez, L; Tavano, L; Vinardell, MP | 1 |
| Hyun, S; Kim, S; Lee, Y; Yu, J | 1 |
| Abedi, F; Akbarzadeh, A; Alizadeh, E; Annabi, N; Baradaran, B; Davaran, S; Moghaddam, SV | 1 |
16 other study(ies) available for lysine and methotrexate
| Article | Year |
|---|---|
[Chemotherapies and fecondity (author's transl)].
Topics: Alkaloids; Antineoplastic Agents; Dactinomycin; Female; Humans; Infertility, Female; Infertility, Male; Lysine; Male; Methotrexate; Procarbazine | 1979 |
Characterization and cellular localization of nucleophosmin/B23 in HeLa cells treated with selected cytotoxic agents (studies of B23-translocation mechanism).
Topics: Autoradiography; Camptothecin; Cell Nucleolus; Dactinomycin; Electrophoresis, Gel, Two-Dimensional; Electrophoresis, Polyacrylamide Gel; Fluorescent Antibody Technique; HeLa Cells; Humans; Kinetics; Lysine; Methotrexate; Nuclear Proteins; Nucleophosmin; Phosphates; Phosphoproteins; Phosphorus Radioisotopes; Phosphorylation; Protein Processing, Post-Translational; Tritium; Uridine | 1992 |
Synthesis and biological evaluation of a fluorescent analogue of folic acid.
Topics: Binding, Competitive; Biological Transport; Carrier Proteins; Cell Line; Flow Cytometry; Fluoresceins; Fluorescence; Fluorescent Dyes; Folate Receptors, GPI-Anchored; Folic Acid; Humans; Lysine; Methotrexate; Placenta; Receptors, Cell Surface; Substrate Specificity; Tetrahydrofolate Dehydrogenase; Tumor Cells, Cultured | 1991 |
Conversion of arginine to lysine at position 70 of human dihydrofolate reductase: generation of a methotrexate-insensitive mutant enzyme.
Topics: Arginine; Base Sequence; Binding Sites; Folic Acid Antagonists; Gene Conversion; Humans; Kinetics; Lysine; Methotrexate; Molecular Sequence Data; Mutagenesis, Site-Directed; Structure-Activity Relationship; Tetrahydrofolate Dehydrogenase | 1991 |
Separation of methotrexate analogs containing terminal lysine or ornithine and their dansyl derivatives by high-performance liquid chromatography.
Topics: Chromatography, High Pressure Liquid; Dansyl Compounds; Lysine; Methotrexate; Ornithine; Structure-Activity Relationship | 1986 |
Analogues of folate antagonists as affinity and fluorescent probes of dihydrofolate reductase structure and function.
Topics: Affinity Labels; Animals; Folic Acid; Leukemia L1210; Lysine; Methotrexate; Mice; Ornithine; Tetrahydrofolate Dehydrogenase; X-Ray Diffraction | 1986 |
Methotrexate analogues. 30. Dihydrofolate reductase inhibition and in vitro tumor cell growth inhibition by N epsilon-(haloacetyl)-L-lysine and N delta-(haloacetyl)-L-ornithine analogues and an acivicin analogue of methotrexate.
Topics: Acetates; Animals; Candida albicans; Chemical Phenomena; Chemistry; Folic Acid Antagonists; Isoxazoles; Leukemia L1210; Lysine; Methotrexate; Mice; NADP; Ornithine; Protein Conformation; Spectrophotometry | 1987 |
High-performance liquid chromatography of methotrexate analogs containing terminal lysine or ornithine and their dansyl derivatives.
Topics: Chromatography, High Pressure Liquid; Dansyl Compounds; Fluorescence; Glutamates; Lysine; Methotrexate; Ornithine | 1983 |
A mutated murine reduced folate carrier (RFC1) with increased affinity for folic acid, decreased affinity for methotrexate, and an obligatory anion requirement for transport function.
Topics: Amino Acid Substitution; Animals; Anions; Binding Sites; Biological Transport, Active; Carrier Proteins; Drug Resistance, Neoplasm; Folic Acid; Glutamic Acid; Kinetics; Leukemia L1210; Lysine; Membrane Proteins; Membrane Transport Proteins; Methotrexate; Mice; Mutagenesis, Site-Directed; Protein Structure, Secondary; Structure-Activity Relationship; Tumor Cells, Cultured | 1998 |
Mutational analysis of the functional role of conserved arginine and lysine residues in transmembrane domains of the murine reduced folate carrier.
Topics: Animals; Anions; Arginine; Biological Transport; Carrier Proteins; Cells, Cultured; Conserved Sequence; DNA Mutational Analysis; Folic Acid; Folic Acid Antagonists; Lysine; Membrane Proteins; Membrane Transport Proteins; Methotrexate; Mice; Mutagenesis; Reduced Folate Carrier Protein; Transfection | 2001 |
INHIBITION OF SEVERAL ENZYMES BY FOLIC ACID, AMINOPTERIN AND AMETHOPTERIN.
Topics: Amino Acid Oxidoreductases; Aminopterin; Carbonic Anhydrases; Carboxy-Lyases; Carboxypeptidases; Catalase; D-Amino-Acid Oxidase; Enzyme Inhibitors; Folic Acid; Hexokinase; Lysine; Methotrexate; Oxidoreductases; Peroxidases; Research; Uric Acid | 1964 |
Methotrexate reduces the levels of pentosidine and 8-hydroxy-deoxy guanosine in patients with rheumatoid arthritis.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Antirheumatic Agents; Arginine; Arthritis, Rheumatoid; Creatinine; Deoxyguanosine; DNA Damage; Humans; Joints; Lysine; Methotrexate; Oxidative Stress; Oxygen; Reactive Oxygen Species; Time Factors; Treatment Outcome | 2007 |
Role of lysine 411 in substrate carboxyl group binding to the human reduced folate carrier, as determined by site-directed mutagenesis and affinity inhibition.
Topics: Affinity Labels; Biological Transport; Esters; Folic Acid Antagonists; HeLa Cells; Humans; Kinetics; Lysine; Membrane Transport Proteins; Methotrexate; Mutagenesis, Site-Directed; Mutant Proteins; Protein Structure, Tertiary; Reduced Folate Carrier Protein; Structure-Activity Relationship; Succinimides; Transfection | 2008 |
In vitro antitumor activity of methotrexate via pH-sensitive chitosan nanoparticles.
Topics: Antimetabolites, Antineoplastic; Apoptosis; Cell Cycle; Cell Survival; Chemical Phenomena; Chitosan; Drug Delivery Systems; Feasibility Studies; Fluoresceins; HeLa Cells; Humans; Hydrogen-Ion Concentration; Lysine; MCF-7 Cells; Methotrexate; Microscopy, Fluorescence; Nanoparticles; Surface-Active Agents | 2013 |
Nonhemolytic Cell-Penetrating Peptides: Site Specific Introduction of Glutamine and Lysine Residues into the α-Helical Peptide Causes Deletion of Its Direct Membrane Disrupting Ability but Retention of Its Cell Penetrating Ability.
Topics: Antimetabolites, Antineoplastic; Breast Neoplasms; Cations; Cell Membrane; Cell Survival; Cell-Penetrating Peptides; Drug Delivery Systems; Female; Glutamine; Hemolysis; Humans; Hydrophobic and Hydrophilic Interactions; Lysine; Methotrexate; Mutation; Structure-Activity Relationship; Tumor Cells, Cultured | 2016 |
Lysine-embedded cellulose-based nanosystem for efficient dual-delivery of chemotherapeutics in combination cancer therapy.
Topics: Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Breast Neoplasms; Cell Cycle; Cell Proliferation; Cellulose; Curcumin; Drug Carriers; Drug Delivery Systems; Drug Liberation; Female; Humans; Lysine; Methotrexate; Nanoparticles; Tumor Cells, Cultured | 2020 |