Compounds > lysine
Page last updated: 2024-08-17

lysine and maytansine

lysine has been researched along with maytansine in 10 studies

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (10.00)29.6817
2010's8 (80.00)24.3611
2020's1 (10.00)2.80

Authors

AuthorsStudies
Amphlett, G; Blättler, WA; Lambert, JM; Wang, L; Zhang, W1
Chen, Y; Jacobson, F; Kim, MT; Marhoul, J1
Beck, A; Champion, T; Cianférani, S; Colas, O; Corvaïa, N; Marcoux, J; Van Dorsselaer, A; Wagner-Rousset, E1
Joseph, M; Sandra, K; Sandra, P; Steenbeke, M; Vandenheede, I; Vanhoenacker, G1
Bogalhas, M; Chari, R; Coccia, J; Erickson, HK; Fishkin, N; Keating, TA; Laleau, R; Lambert, JM; Lanieri, L; Pinkas, J; Ponte, JF; Sun, X; Wang, L; Widdison, W; Wilhelm, S; Yoder, NC1
Chen, Y; Deperalta, G; Jacobson, F; Kim, MT; Zheng, L1
Chen, Q; Liu, Y; Ni, P; Sang, H; Wang, G; Yao, L; Ye, H; Zhang, J; Zhou, F1
Arlotta, KJ; Carpenter, JF; Chen, HN; Gandhi, AV; Owen, SC1
Ab, O; Bai, C; Erickson, HK; Jin, S; Keating, TA; Lambert, JM; Maloney, EK; McShea, MA; Tavares, D; Wang, L; Whiteman, KR; Widdison, WC; Wilhelm, A; Wilhelm, SD; Yoder, NC1
Adusumalli, SR; Kalra, N; Purushottam, L; Rai, V; Rawale, DG; Reddy, NC; Shukla, S; Thakur, K1

Other Studies

10 other study(ies) available for lysine and maytansine

ArticleYear
Structural characterization of the maytansinoid-monoclonal antibody immunoconjugate, huN901-DM1, by mass spectrometry.
    Protein science : a publication of the Protein Society, 2005, Volume: 14, Issue:9

    Topics: Amino Acid Sequence; Antibodies, Monoclonal; Glycosylation; Immunoconjugates; Lysine; Maytansine; Metalloendopeptidases; Molecular Sequence Data; Peptide Mapping; Sequence Homology, Amino Acid; Spectrometry, Mass, Electrospray Ionization; Trypsin

2005
Statistical modeling of the drug load distribution on trastuzumab emtansine (Kadcyla), a lysine-linked antibody drug conjugate.
    Bioconjugate chemistry, 2014, Jul-16, Volume: 25, Issue:7

    Topics: Ado-Trastuzumab Emtansine; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Breast Neoplasms; Chromatography, Liquid; Female; Humans; Immunoconjugates; Lysine; Maytansine; Models, Statistical; Molecular Structure; Receptor, ErbB-2; Structure-Activity Relationship; Tandem Mass Spectrometry; Tissue Distribution; Trastuzumab; Tumor Cells, Cultured

2014
Native mass spectrometry and ion mobility characterization of trastuzumab emtansine, a lysine-linked antibody drug conjugate.
    Protein science : a publication of the Protein Society, 2015, Volume: 24, Issue:8

    Topics: Ado-Trastuzumab Emtansine; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Humans; Immunoconjugates; Isomerism; Lysine; Mass Spectrometry; Maytansine; Models, Molecular; Trastuzumab

2015
Multiple heart-cutting and comprehensive two-dimensional liquid chromatography hyphenated to mass spectrometry for the characterization of the antibody-drug conjugate ado-trastuzumab emtansine.
    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2016, Oct-01, Volume: 1032

    Topics: Ado-Trastuzumab Emtansine; Amino Acid Sequence; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Chromatography, Liquid; Equipment Design; Humans; Immunoconjugates; Lysine; Maytansine; Tandem Mass Spectrometry; Trastuzumab

2016
Understanding How the Stability of the Thiol-Maleimide Linkage Impacts the Pharmacokinetics of Lysine-Linked Antibody-Maytansinoid Conjugates.
    Bioconjugate chemistry, 2016, 07-20, Volume: 27, Issue:7

    Topics: Animals; Drug Stability; Immunoconjugates; Lysine; Maleimides; Maytansine; Mice; Structure-Activity Relationship

2016
Structural Characterization of Cross-Linked Species in Trastuzumab Emtansine (Kadcyla).
    Bioconjugate chemistry, 2016, 09-21, Volume: 27, Issue:9

    Topics: Ado-Trastuzumab Emtansine; Amino Acid Sequence; Antibodies, Monoclonal, Humanized; Lysine; Maleimides; Maytansine; Models, Molecular; Peptides; Protein Structure, Secondary; Trastuzumab

2016
LC-MS/MS method for the simultaneous determination of Lys-MCC-DM1, MCC-DM1 and DM1 as potential intracellular catabolites of the antibody-drug conjugate trastuzumab emtansine (T-DM1).
    Journal of pharmaceutical and biomedical analysis, 2017, Apr-15, Volume: 137

    Topics: Ado-Trastuzumab Emtansine; Antibodies; Antibodies, Monoclonal, Humanized; Chromatography, Liquid; Immunoconjugates; Lysine; Maytansine; Tandem Mass Spectrometry; Trastuzumab

2017
Biophysical Properties and Heating-Induced Aggregation of Lysine-Conjugated Antibody-Drug Conjugates.
    Journal of pharmaceutical sciences, 2018, Volume: 107, Issue:7

    Topics: Ado-Trastuzumab Emtansine; Antineoplastic Agents, Immunological; Calorimetry, Differential Scanning; Chromatography, Liquid; Circular Dichroism; Colloids; Heating; Immunoconjugates; Lysine; Mass Spectrometry; Maytansine; Protein Aggregates; Protein Stability; Spectrum Analysis, Raman; Trastuzumab

2018
A Case Study Comparing Heterogeneous Lysine- and Site-Specific Cysteine-Conjugated Maytansinoid Antibody-Drug Conjugates (ADCs) Illustrates the Benefits of Lysine Conjugation.
    Molecular pharmaceutics, 2019, 09-03, Volume: 16, Issue:9

    Topics: Animals; Antibodies, Monoclonal; Cell Survival; Cysteine; Female; HeLa Cells; Humans; Immunoconjugates; Injections, Intravenous; Lysine; Maytansine; Mice; Mice, SCID; Treatment Outcome; Tumor Burden; Uterine Cervical Neoplasms; Xenograft Model Antitumor Assays

2019
Chemoselective and Site-Selective Lysine-Directed Lysine Modification Enables Single-Site Labeling of Native Proteins.
    Angewandte Chemie (International ed. in English), 2020, 06-22, Volume: 59, Issue:26

    Topics: Antineoplastic Agents; Cell Line, Tumor; Drug Screening Assays, Antitumor; Fluorescent Dyes; Humans; Indicators and Reagents; Lysine; Maytansine; Proteins; Trastuzumab

2020