Page last updated: 2024-08-17

lysine and isoxazoles

lysine has been researched along with isoxazoles in 13 studies

Research

Studies (13)

Timeframe	Studies, this research(%)	All Research%
pre-1990	2 (15.38)	18.7374
1990's	0 (0.00)	18.2507
2000's	5 (38.46)	29.6817
2010's	4 (30.77)	24.3611
2020's	2 (15.38)	2.80

Authors

Authors	Studies
Roby, KA; Segal, S	1
Baccanari, DP; Delcamp, TJ; Forsch, RA; Freisheim, JH; Rosowsky, A; Solan, VC	1
Bulut, D; Hanefeld, C; Koll, R; Liaghat, S; Miebach, T; Mügge, A	1
Behr, B; Hoffmann, C; Klotz, KN; Ottolina, G	1
Knauf, PA; Lebedev, D; Pal, P; Salim, S	1
Salzberg, DJ; Weir, MR	1
Huntsman, MM; Krook-Magnuson, EI; Li, P; Paluszkiewicz, SM	1
Conway, SJ; Fedorov, O; Filippakopoulos, P; Heightman, TD; Hewings, DS; Knapp, S; Marsden, B; Philpott, M; Picaud, S; Uttarkar, S; Vuppusetty, C; Wang, M	1
Brennan, PE; Conway, SJ; Fedorov, O; Filippakopoulos, P; Freeman, K; Gill, A; Hammond, EM; Hewings, DS; Knapp, S; Martin, S; Olcina, MM; Picaud, S; Ritchie, AJ; Russell, AJ; Sheppard, DW; Tumber, A; Wells, C	1
Abburi, C; Gallagher, K; McDaid, J; McGehee, DS; Wolfman, SL	1
Chen, P; Fung, H; Gu, Y; He, S; Hexner, E; Hu, S; Huang, J; Huang, Q; Jin, J; Jin, M; Li, C; Liu, Y; Ma, A; Reshef, R; Tian, Y; Tong, Q; Yu, H; Zhang, Y	1
Channe Gowda, D; Kumara, HK; Pavan Kumar, H; Suhas, R	1
Bruyère, D; Coles, SJ; Edmonds, AK; Felix, R; Hassell-Hart, S; Maple, HJ; Marsh, GP; Oakes, CS; Spencer, J; Tizzard, GJ	1

Reviews

1 review(s) available for lysine and isoxazoles

Article	Year
COX-2 inhibitors and cardiovascular risk. Sub-cellular biochemistry, 2007, Volume: 42 Topics: Blood Pressure; Cardiovascular Diseases; Cyclooxygenase 2 Inhibitors; Humans; Isoxazoles; Lactones; Lysine; Risk Factors; Sulfonamides; Sulfones; Water-Electrolyte Balance	2007

Trials

1 trial(s) available for lysine and isoxazoles

Article	Year
Selective cyclo-oxygenase-2 inhibition with parecoxib acutely impairs endothelium-dependent vasodilatation in patients with essential hypertension. Journal of hypertension, 2003, Volume: 21, Issue:9 Topics: Acetylcholine; Adult; Aged; Aspirin; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Endothelium, Vascular; Female; Forearm; Humans; Hypertension; Isoenzymes; Isoxazoles; Lysine; Male; Membrane Proteins; Middle Aged; Prostaglandin-Endoperoxide Synthases; Regional Blood Flow; Vasodilation; Vasodilator Agents	2003

Article

Year

Selective cyclo-oxygenase-2 inhibition with parecoxib acutely impairs endothelium-dependent vasodilatation in patients with essential hypertension.

Journal of hypertension, 2003, Volume: 21, Issue:9

Topics: Acetylcholine; Adult; Aged; Aspirin; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Endothelium, Vascular; Female; Forearm; Humans; Hypertension; Isoenzymes; Isoxazoles; Lysine; Male; Membrane Proteins; Middle Aged; Prostaglandin-Endoperoxide Synthases; Regional Blood Flow; Vasodilation; Vasodilator Agents

2003

Other Studies

11 other study(ies) available for lysine and isoxazoles

Article	Year
Cystine and lysine reabsorption in the isolated perfused rat kidney. The American journal of physiology, 1989, Volume: 256, Issue:5 Pt 2 Topics: Amino Acids; Animals; Cystine; gamma-Glutamyltransferase; Glutathione; In Vitro Techniques; Isoxazoles; Kidney; Lysine; Male; Perfusion; Rats; Rats, Inbred Strains	1989
Methotrexate analogues. 30. Dihydrofolate reductase inhibition and in vitro tumor cell growth inhibition by N epsilon-(haloacetyl)-L-lysine and N delta-(haloacetyl)-L-ornithine analogues and an acivicin analogue of methotrexate. Journal of medicinal chemistry, 1987, Volume: 30, Issue:8 Topics: Acetates; Animals; Candida albicans; Chemical Phenomena; Chemistry; Folic Acid Antagonists; Isoxazoles; Leukemia L1210; Lysine; Methotrexate; Mice; NADP; Ornithine; Protein Conformation; Spectrophotometry	1987
Novel mutants of the human beta1-adrenergic receptor reveal amino acids relevant for receptor activation. The Journal of biological chemistry, 2006, Jun-30, Volume: 281, Issue:26 Topics: Adrenergic beta-Agonists; Amino Acid Sequence; Animals; Aspartic Acid; CHO Cells; Cricetinae; Humans; Isoleucine; Isoxazoles; Ligands; Lysine; Molecular Sequence Data; Mutagenesis; Protein Structure, Secondary; Protein Structure, Tertiary; Radioligand Assay; Receptors, Adrenergic, beta-1; Terbutaline; Valine	2006
Substrates induce conformational changes in human anion exchanger 1 (hAE1) as observed by fluorescence resonance energy transfer. Biochemistry, 2006, May-23, Volume: 45, Issue:20 Topics: Anion Exchange Protein 1, Erythrocyte; Barbiturates; Binding Sites; Energy Transfer; Erythrocyte Membrane; Erythrocytes; Fluoresceins; Fluorescence Resonance Energy Transfer; Humans; Ion Transport; Isoxazoles; Lysine; Models, Biological; Protein Binding; Protein Conformation; Substrate Specificity; Thermodynamics; Thiobarbiturates	2006
Tonically active inhibition selectively controls feedforward circuits in mouse barrel cortex. Journal of neurophysiology, 2008, Volume: 100, Issue:2 Topics: Action Potentials; Animals; Cerebral Cortex; Dose-Response Relationship, Radiation; Electric Stimulation; Female; GABA Agonists; In Vitro Techniques; Isoxazoles; Lysine; Male; Mice; Mice, Inbred C57BL; Nerve Net; Neural Inhibition; Neurons; Patch-Clamp Techniques; Receptors, GABA-A; Thalamus	2008
3,5-dimethylisoxazoles act as acetyl-lysine-mimetic bromodomain ligands. Journal of medicinal chemistry, 2011, Oct-13, Volume: 54, Issue:19 Topics: Cell Cycle Proteins; CREB-Binding Protein; Crystallography, X-Ray; Cytotoxins; HeLa Cells; Histones; Humans; Isoxazoles; Ligands; Lysine; Models, Molecular; Molecular Mimicry; Molecular Structure; Nuclear Proteins; Phenylethyl Alcohol; Protein Binding; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Stereoisomerism; Structure-Activity Relationship; Transcription Factors	2011
Optimization of 3,5-dimethylisoxazole derivatives as potent bromodomain ligands. Journal of medicinal chemistry, 2013, Apr-25, Volume: 56, Issue:8 Topics: Acetylation; Cell Cycle Proteins; Cell Line, Tumor; CREB-Binding Protein; Crystallography, X-Ray; Histones; Humans; Inhibitory Concentration 50; Isoxazoles; Ligands; Lysine; Nuclear Proteins; Protein Binding; Structure-Activity Relationship; Transcription Factors	2013
Ethanol-Induced Motor Impairment Mediated by Inhibition of α7 Nicotinic Receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2016, 07-20, Volume: 36, Issue:29 Topics: alpha7 Nicotinic Acetylcholine Receptor; Animals; Central Nervous System Depressants; Cholinergic Agents; Cholinesterases; Cyclic AMP; Dose-Response Relationship, Drug; Enzyme Inhibitors; Ethanol; Excitatory Amino Acid Antagonists; In Vitro Techniques; Isoxazoles; Lysine; Male; Motor Disorders; Neurotransmitter Agents; Phenylurea Compounds; Phosphorylation; Quinoxalines; Rats; Rats, Sprague-Dawley; Synaptic Potentials	2016
Hsp90 inhibition destabilizes Ezh2 protein in alloreactive T cells and reduces graft-versus-host disease in mice. Blood, 2017, 05-18, Volume: 129, Issue:20 Topics: Animals; Enhancer of Zeste Homolog 2 Protein; Graft vs Host Disease; Hematopoiesis; Hematopoietic Stem Cell Transplantation; Histones; HSP90 Heat-Shock Proteins; Indoles; Isoxazoles; Lysine; Methylation; Mice, Inbred BALB C; Mice, Inbred C57BL; Minor Histocompatibility Antigens; Protein Domains; Protein Stability; Pyridones; Resorcinols; T-Lymphocytes; Transplantation, Homologous	2017
Multitarget-directed therapeutics: (Urea/thiourea) Archiv der Pharmazie, 2021, Volume: 354, Issue:7 Topics: Anti-Infective Agents; Anti-Inflammatory Agents; Antioxidants; Heterocyclic Compounds; Humans; Isoxazoles; Lysine; Molecular Docking Simulation; Piperazines; Piperidines; Structure-Activity Relationship; Thiourea; Urea	2021
Scale-up and optimization of the synthesis of dual CBP/BRD4 inhibitor ISOX-DUAL. Organic & biomolecular chemistry, 2022, 05-18, Volume: 20, Issue:19 Topics: Cell Cycle Proteins; Isoxazoles; Lysine; Nuclear Proteins; Protein Domains; Transcription Factors	2022