lysine has been researched along with isomethyleugenol in 2555 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 214 (8.38) | 18.7374 |
| 1990's | 51 (2.00) | 18.2507 |
| 2000's | 681 (26.65) | 29.6817 |
| 2010's | 1324 (51.82) | 24.3611 |
| 2020's | 285 (11.15) | 2.80 |
| Authors | Studies |
|---|---|
| Bradbury, JH; Brown, LR | 3 |
| Ebert, C; Ebert, G | 1 |
| Gassen, HG; Khanh, NQ; Lipecky, R | 1 |
| Kakimoto, Y; Konishi, H; Matsuoka, Y; Miyake, M | 1 |
| Miyake, M | 1 |
| Léonis, J; Looze, Y; Polastro, E | 1 |
| Crichton, RR; De Wolf, B; Parfait, R | 1 |
| Mozes, E | 1 |
| Hayashi, H; Koiwai, O; Ohba, M; Tanada, S | 1 |
| Broquist, HP; Rebouche, CJ | 1 |
| Dimaria, P; Kim, S; Paik, WK; Pearson, E | 1 |
| Warme, PK | 1 |
| Lapis, K; Szende, B; Tyihák, E | 1 |
| Durban, E; Kim, S; Nochumson, S; Paik, WK | 1 |
| Deconinck, MM; Devogel, MR; Leonis, J; Looze, YR; Mailier, EL; Polastro, ET; Schnek, AG | 1 |
| Kakiuchi, S; Miyake, M | 1 |
| Bosshard, HR; Rieder, R | 1 |
| Bosshard, HR | 1 |
| Barnes, WT; Kalasz, H; Kovacs, GH; Nagy, J; Tyihak, E | 1 |
| Baxter, CS; Byvoet, P; Sayre, DF | 2 |
| Colson, C | 1 |
| Chang, FN | 1 |
| Kim, S; Nochumson, S; Paik, WK | 2 |
| Hartley, BS; Kraal, B | 1 |
| L'Italien, JJ; Laursen, RA | 1 |
| ElAmin, B; Means, GE | 1 |
| Hempel, K; Lange, HW; Roos, G; Stöcker, W; Thomas, G | 1 |
| Allfrey, VG; Boffa, LC; Sterner, R; Vidali, G | 1 |
| Dearborn, DG; Gerken, TA; Jentoft, JE; Jentoft, N | 2 |
| Deyl, Z; Helm, R; Vancikova, O | 1 |
| Cagan, RH; Deibler, G; Martenson, RE; Morris, RW | 1 |
| Cherkasov, IA; Chstiakova, LA; Kravchenko, NA | 1 |
| Bursics, L; Jeney, A; Kopper, L; Lapis, K; Szarvas, T; Szende, B; Tyihák, E; Ujhelyi, E | 1 |
| Morgan, HE; Watkins, CA | 1 |
| Kakimoto, Y; Miyake, M | 2 |
| Chang, CN; Chang, N | 1 |
| Furano, AV; Klagsbrun, M | 1 |
| Bailey, FJ; Beckerton, A; Bolton, N; Buttery, PJ | 1 |
| Hempel, K; Lange, HW | 2 |
| Hempel, K; Lange, HW; Thomas, G | 2 |
| Huszar, G | 4 |
| Candido, EP; Dixon, GH; Honda, BM | 1 |
| Candido, PM; Dixon, GH; Honda, BM | 1 |
| Chakrabarty, S; Duerre, JA | 1 |
| Ferenz, HJ; Roehrkasten, A | 1 |
| Lazarides, E; Lin, JM; Wang, C | 1 |
| Kim, S; Paik, WK; Rajpurohit, R; Syed, S | 1 |
| Lund-Katz, S; Phillips, MC; Sparks, DL | 1 |
| Bello, J | 1 |
| Gerhardt, KO; Katz, ML | 1 |
| Bergman, LW; Cessay, KJ; Tuck, MT | 1 |
| Ito, S; Matsumoto, H; Miyazaki, T; Suzuki, K | 1 |
| Andrisani, OM; Dixon, JE | 1 |
| Katz, ML; Rodrigues, M | 1 |
| Cleary, S; DeVos, AM; Kelley, RF | 1 |
| Goldberg, M; Jennissen, HP; Rakutt, WD; Ziegenhagen, R | 1 |
| Barber, CV; Mannik, M; Nardella, FA; Teller, DC | 1 |
| Janas, T; Kilian, M; Przestalski, S | 1 |
| Kung, C; Lukas, TJ; Wallen-Friedman, M; Watterson, DM | 1 |
| Jentoft, JE; Rayford, R | 1 |
| Sherman, M; Sypherd, PS | 1 |
| Dick, LR; Geraldes, CF; Gray, CW; Gray, DM; Sherry, AD | 1 |
| Carvounis, CP; Carvounis, G; Wilk, BJ | 1 |
| Chêne, N; de la Llosa, P; Martal, J | 2 |
| Lukas, TJ; Roberts, DM; Rowe, PM; Siegel, FL; Watterson, DM | 1 |
| Lyon, M | 1 |
| Amidei, K; Barber, M; Byvoet, P; Lowell, N; Trudeau, W | 1 |
| Blank, GS; George, E; Rosenberry, TL; Sternlicht, H; Szasz, J; Yaffe, MB | 1 |
| Jancso, A; Lu, RC; Szilagyi, L | 1 |
| Lambert, SF; Thomas, JO | 1 |
| Bordás, B; Cserháti, T; Tyihák, E | 1 |
| Bosch, L; Johanns, ES; Kraal, B; Persoon, NL; Sinjorgo, KM; Van Noort, JM | 1 |
| Kakimoto, Y; Kawamoto, T; Miyake, M; Morino, H | 1 |
| Klaude, M; von der Decken, A | 1 |
| Barber, DL; George, R; Schneider, WJ | 1 |
| Harper, JW; Lobb, RR | 1 |
| Desrosiers, R; Tanguay, RM | 1 |
| Hubert, E; Iriarte, A; Martinez-Carrion, M; Roberts, WJ | 1 |
| Mann, DM; Vanaman, TC | 1 |
| Hong, SY; Kim, S; Lee, HW; Paik, WK; Park, KS; Shin, S | 1 |
| Ibdah, JA; Letizia, JY; Lund-Katz, S; Phillips, MC; Thomas, MT | 1 |
| Dick, LR; Gray, DM; Newkirk, MM; Sherry, AD | 1 |
| DasGupta, BR; Sathyamoorthy, V | 1 |
| Ivanov, VO; Kosykh, VA; Preobrazhensky, SN; Repin, VS; Smirnov, VN; Tsibulsky, VP | 1 |
| Inoue, R; Kakimoto, Y; Miyaka, M; Mizobuchi, M | 1 |
| Longstaff, C; Rando, RR | 1 |
| Reporter, M | 1 |
| Barker, GR; Hodges, P | 1 |
| Elzinga, M; Huszar, G | 1 |
| Broquist, HP; Horne, DW | 1 |
| Garcet, S; Huyen, VN; Servin, A | 1 |
| Bauer, S; Masler, L; Sikl, D | 1 |
| Egan, ML; Maurer, PH; Smyth, RD | 1 |
| Byvoet, P | 3 |
| Bećarević, A; Sein, KT | 1 |
| Chuang, RY; Doi, RH | 1 |
| Kothari, RM; Shankar, V; Taylor, MW | 1 |
| Evans, J; Kimball, A; Nixon, J; Spoor, T | 1 |
| Cheng, ST; Lauzon, G; Tsai, CS; Tsai, YH | 1 |
| Baxter, CS; Byvoet, P | 1 |
| Bhattacharyya, A; Jeanloz, RW; Roberts, GP | 1 |
| Ascoli, M; Puett, D | 1 |
| Edgar, DH; Hope, DB | 1 |
| Duerre, JA; Lee, CT | 1 |
| Lapis, K; Stotz, GY; Szende, B; Tyihák, E | 1 |
| Melnikova, AF; Mirzabekov, AD | 1 |
| Evans, HJ; Hill, RL; Steinman, HM | 1 |
| Möller, W; Terhorst, C; Wittmann-Liebold, B | 1 |
| Crichton, RR; Moore, G | 1 |
| Dudock, B; Michael, M; Roe, B | 1 |
| Amons, R; Möller, W | 1 |
| Haber, JE; Wejksnora, PJ | 1 |
| Bonner, J; Douvas, AS; Johnson, JD | 1 |
| Chang, CN; Chang, FN; Paik, WK | 1 |
| Banks, TE; Shafer, JA | 2 |
| Hempel, K; Lange, HW; Löwer, R | 3 |
| McKay, IC; Wilkinson, PC | 1 |
| Borun, TW; Lee, HW; Paik, WK | 1 |
| Franchi-Gazzola, R; Gazzola, GC; Guidotti, GG; Ronchi, P | 1 |
| Fitzgerald, PJ; Marsh, WH | 1 |
| De la Llosa, P; Durosay, M; Jutisz, M; Tertrin-Clary, C | 1 |
| Shinoda, T; Tsuzukida, Y | 1 |
| Kass, L | 1 |
| Klyszejko-Stefanowicz, L; Lipińska, A | 1 |
| Yamamoto, H; Yang, JT | 1 |
| Eichhorn, C; Hempel, K; Lange, H; Löwer, R | 1 |
| Dekker, EE; Hansen, BA; Lane, RS | 1 |
| Cuprak, LJ; Liss, M; Maxam, AM | 1 |
| Fukui, T; Itoh, T; Osawa, S; Otaka, E | 1 |
| Kagamiyama, H; Morino, Y; Snell, EE | 1 |
| DeLange, RJ; Smith, EL | 1 |
| Chandra, P; Kersten, H; Kersten, W; Tanck, W; Wiedemhöver, W | 1 |
| Goldman, M; Griffin, AC | 1 |
| Kakimoto, Y | 1 |
| Diederich, J; Lauschke, U; Lodemann, E; Mohrbutter, K; Wacker, A | 1 |
| Korn, ED; Weihing, RR | 2 |
| Borun, TW; Paik, WK; Pearson, D | 1 |
| Lee, HW; Paik, WK | 1 |
| Kim, S; Lee, HW; Paik, WK | 1 |
| Byvoet, P; Hardin, JM; Noland, BJ; Shepherd, GR | 1 |
| Kim, S; Paik, WK | 4 |
| Jacq, C; Lederer, F | 1 |
| Ferri, G; Forcina, BG; Ronchi, S; Zapponi, MC | 1 |
| Kopper, L; Lapis K Tyihák, E; Szende, B | 1 |
| Hardin, JM; Noland, BJ; Shepherd, GR | 1 |
| Héléne, C; Leng, M; Ramstein, J | 1 |
| Gallwitz, D | 1 |
| Boulter, D; Ramshaw, JA; Richardson, M | 1 |
| Benoiton, NL; Coggins, JR; Demayo, RE; Moore, GJ | 1 |
| Krzysik, B; McManus, I; Vergnes, JP | 1 |
| Kaye, AM; Sheratzky, D | 1 |
| Benoiton, NL; Seely, JH | 2 |
| Mitchell, HK; Scott, WA | 1 |
| Hardy, M; Harris, I; Perry, SV; Stone, D | 1 |
| Kanarek, L; Strosberg, AD | 1 |
| Akazawa, S; Kakimoto, Y | 1 |
| Bonner, J; DeLange, RJ; Smith, EL | 1 |
| Burdon, RH | 1 |
| Corbin, JL; Reporterer, M | 1 |
| Baratti, J; Desnuelle, P; Maroux, S | 1 |
| Allfrey, VG; Mirsky, AE; Tidwell, T | 1 |
| Diamond, S; Hansen, S; Perry, TL | 1 |
| Bonner, J; DeLange, RJ; Fambrough, DM; Smith, EL | 1 |
| Taber, RL; Vincent, WS | 1 |
| Davies, DD; Patterson, BD | 1 |
| Birkofer, L; Hempel, K; Lange, HW | 2 |
| Harris, CM | 1 |
| Allfrey, VG; Gershey, EL; Haslett, GW; Vidali, G | 1 |
| Dimaria, P; Farooqui, J; Kim, CS; Kim, S; Kueppers, F; Paik, WK | 1 |
| Delahunty, MD; Flowers, BK; Karpel, RL; Merkler, DJ | 1 |
| Allfrey, VG; Boffa, LC; Gruss, RJ | 1 |
| Biemann, K; Gupta, CM; Huang, KS; Khorana, HG; Liao, MJ; Royal, N | 1 |
| Farooqui, J; Gupta, A; Millett, F; Paik, WK; Smith, HT | 1 |
| Riordan, JF; Shapiro, R | 1 |
| Rosenberry, TL; Sherman, G; Sternlicht, H | 1 |
| Batstone-Cunningham, RL; Dill, K; Hardy, RE | 1 |
| Alonzo, N; Elzinga, M | 1 |
| Marsh, JW; Nahum, A; Steiner, DF | 1 |
| Rusznák, I; Szarvas, T; Szende, B; Trézl, L; Tyihák, E | 1 |
| Lazarides, E; Wang, C | 1 |
| Feeney, RE; Osuga, DT; Wong, WS | 1 |
| Goux, WJ; Sherry, AD; Teherani, J | 1 |
| James, TL; Keepers, J; Sherry, AD; Teherani, J | 1 |
| Dunn, WA; Englard, S; Rettura, G; Seifter, E | 1 |
| Paik, WK | 1 |
| Curtiss, LK; Fisher, M; Steinbrecher, UP; Witztum, JL | 1 |
| Gray, DM; Kansy, JW; Sherry, AD; Teherani, J | 1 |
| Holcombe, KS; Innerarity, TL; Mahley, RW; Melchior, GW; Weisgraber, KH | 1 |
| Rusznák, I; Trézl, L; Tyihák, E | 1 |
| Bursics, L; Gyapay, G; Jeney, A; Lapis, K; Szende, B; Tyihák, E | 1 |
| Cox, R; Tuck, MT | 1 |
| Calvo-Fernandez, P; Martinez-Carrion, M | 1 |
| Lou, MF; Siena, M | 1 |
| Goodman, DS; Kawakami, M | 1 |
| Blankenship, DT; Harmony, JA; Hui, DY; Noel, JG | 1 |
| Benya, PD; Cheung, DT; Gorn, A; Nimni, ME | 1 |
| Jennings, ML | 1 |
| Clarke, S; Lazarides, E; O'Connor, CM; Wang, C | 1 |
| Garcia, R; Hiatt, WR; Merrick, WC; Sypherd, PS | 1 |
| Rushbrook, JI; Stracher, A; Yuan, AI | 1 |
| Turco, J; Winkler, HH | 1 |
| Franke, P; Hatanaka, Y; Hucho, F; Machold, J; Tsetlin, VI; Utkin, YN | 1 |
| Dedova, IV; Levitskiĭ, DI; Nikolaeva, OP; Pavlov, DA; Poglazov, BF; Potekhin, SA | 1 |
| Buss, JE; Cochrane, CG; Der, CJ; Jackson, JH; Li, JW | 1 |
| Thulin, E; Vogel, HJ; Zhang, M | 1 |
| Fruchart, JC; Leroy, A; Lippens, G; Parra, HJ; Wieruszeski, JM | 1 |
| Bergman, LW; Ceesay, KJ; Rider, LR; Tuck, MT | 1 |
| Bivin, DB; Khoroshev, M; Morales, M; Ue, K | 1 |
| Sternlicht, H; Szasz, J; Yaffe, MB | 1 |
| Tokai, H; Yokota, A | 1 |
| Huque, ME; Vogel, HJ | 1 |
| Christianson, JS; Gao, CL; Katz, ML; Koppang, N; Norbury, NE; Siakotos, AN | 1 |
| Asin, KE; Bednarz, L; Bennett, MJ; Bianchi, BR; Gore, PA; Miller, TR; Nikkel, AL; Stashko, M; Wang, SS; Witte, DG | 1 |
| Mavri, J; Vogel, HJ | 1 |
| Lund-Katz, S; Mahley, RW; Phillips, MC; Weisgraber, KH | 1 |
| Aswad, DW; Henzel, WJ; Potter, SM | 1 |
| Holden, HM; Rayment, I; Rypniewski, WR | 1 |
| Rayment, I; White, HD | 1 |
| Steinbrecher, UP; Yang, Y; Zhang, H | 1 |
| Waterborg, JH | 2 |
| Dunten, RL; Kaback, HR; Sahin-Tóth, M | 1 |
| Cavallius, J; Chakraburtty, K; Merrick, WC; Zoll, W | 1 |
| Hofmann, KP; Jäger, S; Palczewski, K | 1 |
| Kneale, GG; Taylor, IA; Webb, M | 1 |
| Bobkov, AA; Dedova, IV; Golitsina, NL; Levitsky, DI; Nikolaeva, OP; Orlov, VN; Pavlov, DA | 1 |
| Falick, AM; Nadeau, OW; Woodworth, RC | 1 |
| Sherman, F; Takakura, H; Yamamoto, T | 1 |
| Cavallius, J; Merrick, WC; Popkie, AP | 1 |
| Morrice, NA; Raliegh, J; Wettenhall, RE; Williamson, NA | 1 |
| Annila, A; Kovanen, PT; Oörni, K; Pentikäinen, MO | 1 |
| Hansson, H; Härd, T; Knapp, S; Ladenstein, R; Lundbäck, T | 1 |
| Dumont, ME; Mauk, AG; Pollock, WB; Rosell, FI; Twitchett, MB | 1 |
| Hayamizu, T; Kudoh, S; Nakamura, H | 1 |
| Kobayashi, M; Kubota, M; Matsuura, Y | 1 |
| Bairoch, A; Binz, PA; Gasteiger, E; Gooley, AA; Herbert, BR; Hochstrasser, DF; Molloy, MP; Ou, K; Sanchez, JC; Wilkins, MR; Williams, KL | 1 |
| Monnier, VM; Obrenovich, M; Saxena, AK; Saxena, P; Weiss, MF; Wu, X | 1 |
| Inoue, F; Kinugasa, A; Kizaki, Z; Nakajima, H; Okochi, M; Sawada, T; Terada, N | 1 |
| Allis, CD; Cook, RG; Ohba, R; Strahl, BD | 1 |
| Cobb, JA; Roberts, DM | 1 |
| Das, B; Martzen, MR; Phizicky, EM; Polevoda, B; Sherman, F | 1 |
| Bredesen, D; Ellerby, HM; Ellerby, LM; Kluck, RM; Margoliash, E; Mauk, AG; Naiem, S; Newmeyer, DD; Sherman, F; Yaffe, MP | 1 |
| Lamkin, MS; Oppenheim, FG; Yao, Y | 1 |
| Allis, CD; Eisenhaber, F; Jenuwein, T; Mechtler, K; O'Carroll, D; Opravil, S; Ponting, CP; Rea, S; Schmid, M; Strahl, BD; Sun, ZW | 1 |
| Irvin, JD; Kurinov, IV; Mao, C; Uckun, FM | 1 |
| Jenuwein, T; Lachner, M; Mechtler, K; O'Carroll, D; Rea, S | 1 |
| Allshire, RC; Bannister, AJ; Kouzarides, T; Miska, EA; Partridge, JF; Thomas, JO; Zegerman, P | 1 |
| Trouche, D; Vandel, L | 1 |
| Allis, CD; Grewal, SI; Nakayama , J; Rice, JC; Strahl, BD | 1 |
| Berger, SL | 1 |
| Fukushima, T; Shinkai, Y; Sugimoto, K; Tachibana, M | 1 |
| Allis, CD; Rice, JC | 1 |
| Taylor, IA; Webb, M | 1 |
| Allis, CD; Briggs, SD; Erdjument-Bromage, H; Feng, Q; Huang, ZQ; Strahl, BD; Tempst, P; Wang, H; Wong, J; Xia, L; Zhang, Y | 1 |
| Bannister, AJ; Bauer, UM; Cleary, M; Firestein, R; Herrera, RE; Jenuwein, T; Kouzarides, T; Morrison, A; Nielsen, SJ; O'Carroll, D; Schneider, R | 1 |
| Allis, CD; Felsenfeld, G; Gaszner, M; Litt, MD; Simpson, M | 1 |
| Allis, CD; Grewal, SI | 1 |
| Becker, PB; Brehm, A; Czermin, B; Hülsmann, BB; Imhof, A; Reuter, G; Schotta, G | 1 |
| Bird, A | 1 |
| Allis, CD; Boggs, BA; Cheung, P; Chinault, AC; Heard, E; Spector, DL | 1 |
| Brockdorff, N; Jenuwein, T; Mermoud, JE; O'Carroll, D; Pagani, M; Peters, AH; Schweizer, D | 1 |
| Aasland, R; Pijnappel, WW; Roguev, A; Schaft, D; Shevchenko, A; Stewart, AF; Wilm, M | 1 |
| Allis, CD; Aswad, DW; Baumann, CT; Hager, GL; Jelinek, MA; Li, H; Ma, H; Rice, R; Stallcup, MR; Strahl, BD | 1 |
| Allis, CD; Briggs, SD; Bryk, M; Cheung, WL; Davie, JK; Dent, SY; Strahl, BD; Winston, F | 1 |
| Cleary, ML; Griesenbeck, J; Kornberg, RD; Nagy, PL | 1 |
| Borchers, C; Cao, R; Erdjument-Bromage, H; Tempst, P; Wang, H; Xia, L; Zhang, Y | 1 |
| Dover, J; Greenblatt, JF; Johnston, M; Khorrami, S; Krogan, NJ; Schneider, J; Shilatifard, A | 1 |
| Brockdorff, N; Jenuwein, T; Mermoud, JE; Peters, AH; Popova, B | 1 |
| Canas, B; Kouzarides, T; Pappin, D; Zegerman, P | 1 |
| Jacobs, SA; Khorasanizadeh, S | 1 |
| Ayyanathan, K; Maul, GG; Negorev, D; Rauscher, FJ; Schultz, DC | 1 |
| Bannister, AJ; Schneider, R | 1 |
| Jenuwein, T; Lachner, M | 1 |
| Aucott, R; Bongiorni, S; Burgoyne, PS; Cowell, IG; Fanti, L; Fundele, R; Gilbert, DM; Huskisson, N; Jeppesen, P; Mahadevaiah, SK; Morrison, H; Pimpinelli, S; Prantera, G; Shi, W; Singh, PB; Wu, R | 1 |
| Dean, K; Dover, J; Johnston, M; Schneider, J; Shilatifard, A; Tawiah-Boateng, MA; Wood, A | 1 |
| Colot, V; Gendrel, AV; Lippman, Z; Martienssen, RA; Yordan, C | 1 |
| Erdjument-Bromage, H; Feng, Q; Ng, HH; Struhl, K; Tempst, P; Wang, H; Zhang, Y | 2 |
| Dalgaard, JZ; Varga-Weisz, PD | 1 |
| Allis, CD; Chuikov, S; Erdjument-Bromage, H; Lis, JT; Nishioka, K; Reinberg, D; Rice, JC; Sarma, K; Steward, R; Tempst, P; Valenzuela, P; Wang, Y; Werner, J | 1 |
| Bannister, AJ; Kouzarides, T; Schneider, R | 1 |
| Blankenship, JW; Burlingame, AL; Huang, L; Jones, PR; Tang, H; Xiang, F; Yau, PM; Zhang, K | 1 |
| Fukuda, M; Kato, H; Niida, H; Nozaki, M; Ohki, M; Ohta, T; Shinkai, Y; Sugimoto, K; Tachibana, M; Takeda, N; Ueda, J | 1 |
| Bifani, P; Debrie, AS; Drobecq, H; Locht, C; Menozzi, FD; Pethe, K; Sergheraert, C | 1 |
| Helliger, W; Koutzamani, E; Lindner, HH; Rundquist, I; Sarg, B | 1 |
| Ng, HH; Struhl, K; Xu, RM; Zhang, Y | 1 |
| Grewal, SI; Hall, IM; Kidner, C; Martienssen, RA; Teng, G; Volpe, TA | 1 |
| Allshire, R | 1 |
| Grewal, SI; Noma, K | 1 |
| Natoli, G; Saccani, S | 1 |
| Allis, CD; Nishioka, K; Reinberg, D; Rice, JC; Sarma, K; Steward, R | 1 |
| Allis, CD; Coyne, RS; Taverna, SD | 1 |
| Cao, R; Erdjument-Bromage, H; Jones, RS; Tempst, P; Wang, H; Wang, L; Xia, L; Zhang, Y | 1 |
| Bannister, AJ; Bernstein, BE; Emre, NC; Kouzarides, T; Mellor, J; Santos-Rosa, H; Schneider, R; Schreiber, SL; Sherriff, J | 1 |
| Allshire, RC; Bannister, AJ; Kouzarides, T; Partridge, JF; Scott, KS | 1 |
| Hirohashi, S; Koizume, S; Sekiya, T; Shiraishi, M; Tachibana, K | 1 |
| Gonzales, FA; Jones, PA; Liang, G; Lin, JC; Nguyen, CT; Velicescu, M; Weisenberger, DJ | 1 |
| Azorsa, DO; Barlev, NA; Berger, SL; Chow, VT; Goo, YH; Jung, DJ; Kang, MJ; Kim, DH; Kim, SW; Kwak, E; Lee, JW; Lee, KJ; Lee, YC; Meltzer, PS; Roeder, RG; Sohn, YC; Song, EJ; Suh, PG | 1 |
| Issa, JP; Kondo, Y; Shen, L | 1 |
| Aasland, R; Roguev, A; Schaft, D; Shevchenko, A; Stewart, AF | 1 |
| Bauer, UM; Berger, S; Daujat, S; Kouzarides, T; Shah, V; Turner, B | 1 |
| Case, CC; Gregory, PD; Pabo, CO; Snowden, AW | 1 |
| Chang, JH; Cho, Y; Joachimiak, A; Kim, YC; Kwak, E; Kwon, T; Lee, CW; Lee, J | 1 |
| Boateng, MA; Dean, K; Dover, J; Golshani, A; Greenblatt, JF; Heidt, J; Johnston, M; Krogan, NJ; Schneider, J; Shilatifard, A; Wood, A; Zhang, Y | 1 |
| Farooq, A; Koch, AW; Manzur, KL; Plotnikova, O; Zeng, L; Zhou, MM | 1 |
| Ciccone, DN; Morshead, KB; Ng, HH; Oettinger, MA; Struhl, K | 1 |
| Marmorstein, R | 1 |
| Nicolas, E; Roumillac, C; Trouche, D | 1 |
| Kalkhoven, E; Martens, JH; Verlaan, M; Zantema, A | 1 |
| Hirota, J; Satomi, Y; Takao, T; Yoshikawa, K | 1 |
| Bresnick, EH; Choi, K; Feng, Q; Im, H; Johnson, KD; Kiekhaefer, CM; Park, C; Zhang, Y | 1 |
| Cao, R; de la Cruz, CC; Fang, J; Mlynarczyk-Evans, SK; Otte, AP; Panning, B; Plath, K; Wang, H; Worringer, KA; Zhang, Y | 1 |
| Boateng, MA; Dean, K; Dover, J; Golshani, A; Greenblatt, JF; Heidt, J; Johnston, M; Krogan, NJ; Ryan, OW; Schneider, J; Shilatifard, A; Wood, A | 1 |
| Allis, CD; Cheng, X; Grewal, SI; McMillen, D; Nakayama, J; Selker, EU; Singh, PB; Tamaru, H; Zhang, X | 1 |
| Bystrova, OV; Knirel, YA; Kocharova, NA; Macieja, Z; Rozalski, A; Shashkov, AS; Torzewska, A; Zatonsky, GV | 1 |
| DiMario, PJ; Pellar, GJ | 1 |
| Murthy, M; Neamati, N; Wang, YX | 1 |
| Issa, JP; Kondo, Y | 1 |
| Turner, BM | 2 |
| Jenuwein, T; Lachner, M; O'Sullivan, RJ | 1 |
| Bustin, M; Cedar, H; Hashimshony, T; Keshet, I; Zhang, J | 1 |
| Bakala, H; Bismuth, J; Borot-Laloi, C; Corman, B; Delaval, E; Friguet, B; Hamelin, M | 1 |
| Gerber, M; Shilatifard, A | 1 |
| Beattie, BK; Boone, C; Buratowski, S; Cagney, G; Canadien, V; Emili, A; Golshani, A; Greenblatt, J; Kim, M; Krogan, NJ; Richards, DP; Shilatifard, A; Tong, A | 1 |
| Kao, CF; Meehan, RR; Pennings, S | 1 |
| Flynn, EM; Houtz, RL; Hurley, JH; Trievel, RC | 1 |
| Boa, S; Coert, C; Patterton, HG | 1 |
| Grewal, SI; Moazed, D; Motamedi, MR; Shankaranarayana, GD | 1 |
| Bast, RC; Dent, SR; Fujii, S; Issa, JP; Kadota, M; Kondo, Y; Luo, RZ; Oshimura, M; Yu, Y; Yuan, J | 1 |
| Dole, S; Ng, HH; Struhl, K | 1 |
| Dover, J; Johnston, M; Schneider, J; Shilatifard, A; Wood, A | 1 |
| Dutnall, RN | 1 |
| Min, J; Xu, RM; Zhang, Y | 1 |
| Allis, CD; Fischle, W; Jacobs, SA; Khorasanizadeh, S; Kim, Y; Wang, Y | 1 |
| Brockdorff, N; Feil, R; Gomez, M; Goto, Y | 1 |
| Farnham, PJ; Inman, DR; Oberley, MJ | 1 |
| Hesman, T; Johnston, M; Landry, J; Min, J; Sternglanz, R; Sutton, A; Xu, RM | 1 |
| Grigoryev, SA; Istomina, NE; Karpov, VL; Krasheninnikov, IA; Shushanov, SS; Singh, PB; Springhetti, EM; Stevens, K; Zaret, KS | 1 |
| Cocklin, RR; Wang, M | 1 |
| Byrd, KN; Shearn, A | 1 |
| ALLFREY, VG; FAULKNER, R; MIRSKY, AE | 1 |
| KAVERZNEVA, ED; KLEOPINA, GV; KRAVCHENKO, NA | 1 |
| Allis, CD; Ciccone, DN; Morshead, KB; Oettinger, MA; Taverna, SD | 1 |
| Bonifer, C; Follows, GA; Lefevre, P; Morgan, GJ; Tagoh, H | 1 |
| An, W; Cao, R; Chatton, B; Erdjument-Bromage, H; Roeder, RG; Tempst, P; Wang, H; Xia, L; Zhang, Y | 1 |
| Avner, P; Navarro, P; Rougeulle, C | 1 |
| Nishioka, K; Reinberg, D; Sims, RJ | 1 |
| Canaani, E; Cherbas, L; Cherbas, P; Cho, E; Jaynes, JB; Jones, RS; Mazo, A; Petruk, S; Sedkov, Y; Smith, ST | 1 |
| Coetzee, GA; Jia, L; Kim, J; Tilley, WD | 1 |
| Bernstein, BE; Karabetsou, N; Kouzarides, T; Mellor, J; Morillon, A; Santos-Rosa, H; Schneider, R; Schreiber, SL; Weise, C | 1 |
| Liang, X; Lu, Y; Neubert, TA; Resh, MD; Wilkes, M | 1 |
| Andolfo, A; Bertoli, E; Briante, R; Febbraio, F; Formisano, S; Gentile, F; Nucci, R; Pucci, P; Scirè, A; Tanfani, F; Vaccaro, C | 1 |
| Bannister, AJ; Crane-Robinson, C; Kouzarides, T; Myers, FA; Schneider, R; Thorne, AW | 1 |
| Felsenfeld, G; Mutskov, V | 1 |
| Derijck, AA; Jenuwein, T; Kohlmaier, A; Kubicek, S; Martens, JH; Mechtler, K; O'Sullivan, RJ; Opravil, S; Perez-Burgos, L; Peters, AH; Shinkai, Y; Tachibana, M | 1 |
| Allis, CD; Barber, CM; Briggs, SD; Hunt, DF; Rice, JC; Shabanowitz, J; Shinkai, Y; Ueberheide, B | 1 |
| Aoyagi, Y; Kominami, R; Mishima, Y; Obata, M; Togashi, T | 1 |
| Cativiela, C; Díaz-De-Villegas, MD; Gálvez, JA; Ronco, E | 1 |
| Bradbury, ME; Chandrasekhar, B; Imai, BS; Kondrat, R; New, R; Yau, PM; Zhang, K | 1 |
| Gorovsky, MA; Liu, Y; Mochizuki, K | 1 |
| Ghosh, A; Song, MR | 1 |
| Lu, W; Lubkowski, J; Szyk, A; Xu, C | 1 |
| Jenuwein, T; Kauer, M; Mechtler, K; Opravil, S; Perez-Burgos, L; Peters, AH | 1 |
| Nishioka, K; Reinberg, D; Sarma, K | 1 |
| Bannister, AJ; Kouzarides, T | 2 |
| Allison, WS; Bandyopadhyay, S | 1 |
| Cheng, H; He, X; Moore, C | 1 |
| Boeke, J; Bonaldi, T; Czermin, B; Eskeland, R; Imhof, A; Regula, JT | 1 |
| Kee, BL; Perkins, EJ; Ramsden, DA | 1 |
| Bedford, MT; Cheng, D; King, RW; Swanson, MS; Weinstein, EJ; Yadav, N | 1 |
| Kouskouti, A; Scheer, E; Staub, A; Talianidis, I; Tora, L | 1 |
| Aoki, F; Kim, JM; Liu, H | 1 |
| England, P; Halgand, F; Mateescu, B; Muchardt, C; Yaniv, M | 1 |
| Bongiorni, S; Burgoyne, P; Fanti, L; Fundele, R; Gilbert, DM; Jeppesen, P; Kourmouli, N; Mahadevhaiah, S; Pimpinelli, S; Prantera, G; Shi, W; Singh, PB; Wu, R | 1 |
| Jao, CY; Lin, CW; Ting, AY | 1 |
| Albiez, H; Cremer, C; Cremer, M; Cremer, T; Stein, S; Wagler, B; Zinner, R | 1 |
| Ebert, A; Jenuwein, T; Lachner, M; Reinberg, D; Reuter, G; Sarma, K; Schotta, G; Sengupta, R | 1 |
| Aasland, R; Dichtl, B; Keller, W | 1 |
| Camporeale, G; Cerny, R; Sarath, G; Shubert, EE; Zempleni, J | 1 |
| Higashi, T; Imai, K; Iwamoto, H; Masuda, M; Motomiya, Y; Yoshinaka, M | 1 |
| Allis, CD; Avner, P; Chaumeil, J; Heard, E; Reinberg, D; Rougeulle, C; Sarma, K | 1 |
| Jenuwein, T; Lachner, M; Peters, AH; Schotta, G | 1 |
| Carvin, CD; Kladde, MP | 1 |
| Cao, R; Zhang, Y | 2 |
| Herr, W; Julien, E | 1 |
| Ballestar, E; Espada, J; Esteller, M; Fraga, MF; Fuks, F; Juarranz, A; Robertson, KD; Stockert, JC; Villar-Garea, A | 1 |
| Bartley, SM; Farnham, PJ; Green, R; Kirmizis, A; Kuzmichev, A; Margueron, R; Reinberg, D | 1 |
| Trievel, RC | 1 |
| Jenuwein, T; Kohlmaier, A; Lachner, M; Martens, J; Savarese, F; Wutz, A | 1 |
| Bothwell, AL; Calame, K; Hesslein, DG; Johnson, K; Lin, KI; Pflugh, DL; Schatz, DG; Thomas-Tikhonenko, A; Yu, D | 1 |
| Chicas, A; Cogoni, C; Macino, G | 1 |
| Allis, CD; Coonrod, SA; Digilio, LC; Herr, JC; Perlin, J; Sarmento, OF; Wang, Y | 1 |
| Sarraf, SA; Stancheva, I | 1 |
| Atanasiu, D; Berger, SL; Fraser, NW; Gardner, J; Kent, JR; Zeng, PY | 1 |
| Blanton, JL; Gyurkovics, H; Honti, V; Muller, M; Schedl, P; Shanower, GA | 1 |
| Bradbury, EM; Jones, PR; Siino, JS; Yau, PM; Zhang, K | 1 |
| Lepikhov, K; Walter, J | 1 |
| Helliger, W; Koutzamani, E; Lindner, HH; Sarg, B; Talasz, H | 1 |
| Fuchs, J; Goodrich, J; Jacobsen, SE; Jasencakova, Z; Jenuwein, T; Johnson, L; Khorasanizadeh, S; Lindroth, AM; Patnaik, D; Pradhan, S; Schubert, D; Schubert, I; Shultis, D | 1 |
| Ananthanarayanan, M; Balasubramaniyan, N; Li, S; Suchy, FJ; Walsh, MJ | 1 |
| Lee, DY; Stallcup, MR; Strahl, BD; Teyssier, C | 1 |
| Benner, J; Chin, HG; Estève, PO; Jacobsen, SE; Patnaik, D; Pradhan, S | 1 |
| Erdjument-Bromage, H; Pal, S; Sif, S; Tempst, P; Vishwanath, SN | 1 |
| Chao, CC; Ching, WM; Wu, SL | 1 |
| Arney, K; Baxter, J; Caparros, ML; Fisher, AG; Jenuwein, T; John, R; Merkenschlager, M; Otte, A; Peters, A; Sauer, S; Williams, R | 1 |
| Caretti, G; Di Padova, M; Lyons, GE; Micales, B; Sartorelli, V | 1 |
| Barlev, NA; Chuikov, S; Gamblin, SJ; Ivanov, GS; Justin, N; Kurash, JK; McKinney, K; Prives, C; Reinberg, D; Tempst, P; Wilson, JR; Xiao, B | 1 |
| Ditullio, RA; Gorgoulis, VG; Halazonetis, TD; Huyen, Y; Mellert, HS; Petty, TJ; Sheston, EA; Stavridi, ES; Zacharatos, P; Zgheib, O | 1 |
| Beal, MF; Browne, S; D'Mello, S; Ferrante, RJ; Hewett, S; Kristal, BS; Kubilus, JK; Langley, B; Lee, J; Lu, P; Ratan, RR; Rubinsztein, DC; Ryu, H; Smith, K; Stavrovskaya, IG; Sugars, KL | 1 |
| Allshire, RC; Bähler, J; Kouzarides, T; Mata, J; Portoso, M; Sanders, SL | 1 |
| Biron, VL; Hendzel, MJ; Hu, N; McManus, KJ; Underhill, DA | 1 |
| Hamer, KM; Jaenisch, R; Otte, AP; Panning, B; Plath, K; Talbot, D; Yang, TP | 1 |
| Jenuwein, T; Kubicek, S | 1 |
| Casero, RA; Cole, PA; Lan, F; Matson, C; Mulligan, P; Shi, Y; Whetstine, JR | 1 |
| Giannattasio, M; Lazzaro, F; Muzi-Falconi, M; Plevani, P | 1 |
| Li, X; Zhang, FX | 1 |
| Cacciapuoti, G; Concilio, L; Forte, S; Graziano, G; Merlino, A; Moretti, MA; Porcelli, M | 1 |
| Daniel, JA; Grant, PA; Pray-Grant, MG; Schieltz, D; Yates, JR | 1 |
| Arai, D; Higashinakagawa, T; Matsuoka, O; Sakai, A; Shindo, N; Yamasaki, Y | 1 |
| Cheung, P; Lau, P | 1 |
| Bailey, DK; Bekiranov, S; Bernstein, BE; Gingeras, TR; Huebert, DJ; Kamal, M; Karlsson, EK; Kulbokas, EJ; Lander, ES; Lindblad-Toh, K; McMahon, S; Schreiber, SL | 1 |
| Karachentsev, D; Reinberg, D; Sarma, K; Steward, R | 1 |
| Berger, SL; Emre, NC; Greenblatt, JF; Henry, KW; Ingvarsdottir, K; Krogan, NJ; Li, K; Marmorstein, R; Shilatifard, A; Wood, A; Wyce, A | 1 |
| Cervantes-Laurean, D; Jacobson, EL; Jacobson, MK; Roberts, MJ | 1 |
| Li, J; Stewart, MD; Wong, J | 1 |
| Fukuda, M; Hamakubo, T; Iwanari, H; Kodama, T; Ohta, T; Sakihama, T; Shinkai, Y; Tachibana, M; Takeda, N; Ueda, J | 1 |
| Gilbert, DM; Singh, PB; Terry, AV; Wu, R | 1 |
| Greenleaf, AL; Hall, H; Kizer, KO; Phatnani, HP; Shibata, Y; Strahl, BD | 1 |
| Battaglioli, E; Binda, C; Forneris, F; Mattevi, A; Vanoni, MA | 2 |
| Bean, CJ; Kelly, WG; Schmidt, D; Walstrom, KM | 1 |
| Bauer, UM; Behrmann, I; Haan, S; Heinrich, PC; Komyod, W | 1 |
| Chicas, A; Cogoni, C; Forrest, EC; Macino, G; Sepich, S | 1 |
| Bühler, M; Mohn, F; Mühlemann, O; Stalder, L | 1 |
| Cheng, X; Collins, RE; Zhang, X | 1 |
| D'Abreo, C; Fish, JE; Lin, S; Marsden, PA; Matouk, CC; Rachlis, A; Tai, SC | 1 |
| Belmont, AS; Carpenter, AE; de Leeuw, W; van der Kraan, I; van der Vlag, J; van Driel, R; Verschure, PJ | 1 |
| Miao, F; Natarajan, R | 1 |
| Chamberlain, SJ; Chen, A; Kalantry, S; Magnuson, T; Montgomery, ND; Otte, AP; Yee, D | 1 |
| Berden, JH; Braat, DD; de Boer, P; Derijck, AA; Dieker, JW; Muller, S; van der Heijden, GW; van der Vlag, J | 1 |
| Benner, J; Chin, HG; Estève, PO; Patnaik, D; Pradhan, S; Teitell, MA | 1 |
| Karabetsou, N; Mellor, J; Morillon, A; Nair, A | 1 |
| Hassa, PO; Hottiger, MO | 1 |
| Allis, CD; Brivanlou, AH; Burlingame, AL; Dou, Y; Milne, TA; Roeder, RG; Swigut, T; Wysocka, J; Zhang, X | 1 |
| Briggs, SD; Fingerman, IM; Wilson, BD; Wu, CL | 1 |
| Liu, C; Ngai, SM; Tsai, SN; Yin, Y; Zhou, B; Zhu, G | 1 |
| Gopalan, S; Kasza, A; Kiss, DL; Kordula, T; Rydel, RE; Wilczynska, KM; Xu, W | 1 |
| Daniel, JA; Grant, PA; Pray-Grant, MG | 1 |
| Manzur, KL; Zhou, MM | 1 |
| Gardner, RG; Gottschling, DE; Nelson, ZW | 1 |
| Akbarian, S; Baker, SP; Jones, EG; Kolb, G; Rubusch, L; Stadler, F | 1 |
| Cook, JT; McBride, AE; McGrath, KA; Rubens, JA; Rutledge, KL; Stemmler, EA | 1 |
| Choi, YB; Hong, KM; Kim, KS; Ko, MH; Paik, MK; Park, DE; Shin, CH | 1 |
| Greenblatt, JF; Hughes, TR; Krogan, NJ; Laribee, RN; Shibata, Y; Strahl, BD; Xiao, T | 1 |
| Lydall, D; Whitehall, S | 1 |
| Ishii, S; Kanei-Ishii, C; Kurahashi, T; Nomura, T; Shinkai, Y | 1 |
| Andersen, EF; Ketel, CS; Simon, JA; Strome, S; Suh, J; Vargas, ML | 1 |
| Blobel, GA; Mandat, SA; Olenchock, BA; Vakoc, CR | 1 |
| Cooch, N; Lee, MG; Shiekhattar, R; Wynder, C | 1 |
| Grewal, SI; Morris, SA; Noma, K; Shibata, Y; Strahl, BD; Temple, B; Tsukamoto, Y; Warren, E | 1 |
| Adhvaryu, KK; Morris, SA; Selker, EU; Strahl, BD | 1 |
| Schneider, J; Shilatifard, A; Wood, A | 1 |
| Clarke, S; Miranda, TB; Porras-Yakushi, TR; Whitelegge, JP | 1 |
| Cerny, RL; Cerutti, H; Hesson, J; Jeong, BR; Marley, KE; van Dijk, K; Waterborg, JH; Xu, J | 1 |
| Camporeale, G; Chew, YC; Kothapalli, N; Sarath, G; Zempleni, J | 1 |
| Burlingame, AL; Chalkley, RJ; Zhang, X | 1 |
| Abate-Shen, C; Chuikov, S; Farnham, P; Karachentsev, D; Kirmizis, A; Kuzmichev, A; Margueron, R; Nishioka, K; Preissner, TS; Reinberg, D; Sarma, K; Steward, R; Vaquero, A | 1 |
| Jenuwein, T; Lachner, M; Schotta, G; Sengupta, R | 1 |
| Billadeau, DD; Gomez, TS; Nolz, JC | 1 |
| Daujat, S; Happel, N; Schneider, R; Waldmann, T; Zeissler, U | 1 |
| Atkinson, SP; Glasspool, RM; Hoare, SF; Keith, WN | 1 |
| Chakrabarti, SK; Francis, J; Garmey, JC; Mirmira, RG | 1 |
| Chan, GC; Fish, JE; Leung, DD; Marsden, PA; Mawji, IA; Rachlis, AC | 1 |
| Alvarez-Venegas, R; Avramova, Z | 1 |
| Helliger, W; Lindner, HH; Sarg, B; Talasz, H | 1 |
| Allard, S; Côté, J; Javaheri, A; Kron, SJ; Sha, F; Wysocki, R | 1 |
| Dehé, PM; Géli, V; Lebrun, R; Luciano, P; Moinier, D; Pamblanco, M; Sendra, R; Tordera, V; Verreault, A | 1 |
| Cooper, HJ; Hay, RT; Heath, JK; Jaffray, E; Lam, TT; Marshall, AG; Tatham, MH | 1 |
| Martínez-Balbás, MA; Sánchez-Molina, S; Valls, E | 1 |
| Burlingame, AL; Chalkley, RJ; Chu, F; Nusinow, DA; Panning, B; Plath, K | 1 |
| Ababneh, AM; Georghiou, S | 1 |
| Albiez, H; Cremer, M; Cremer, T; Peters, AH; Walter, J; Zinner, R | 1 |
| Moazed, D; Verdel, A | 1 |
| Cha, TL; Chen, CT; Hung, MC; Otte, AP; Ping, B; Wu, Y; Xia, W; Yang, CC; Zhou, BP | 1 |
| Lieb, JD; Rao, B; Shibata, Y; Strahl, BD | 1 |
| Iwabata, H; Komatsu, Y; Yoshida, M | 1 |
| Martin, C; Zhang, Y | 1 |
| Hazzalin, CA; Mahadevan, LC | 1 |
| Chen, CF; Kouzarides, T; Patel, SS; Reinberg, D; Santos-Rosa, H; Sims, RJ | 1 |
| Belmont, AS; Brink, MC; de Leeuw, W; Mateos-Langerak, J; van der Velden, Y; van Driel, R; Verschure, PJ | 1 |
| Ahn, SH; Boone, C; Buratowski, S; Chin, K; Collins, SR; Emili, A; Greenblatt, JF; Grunstein, M; Hughes, TR; Keogh, MC; Krogan, NJ; Kurdistani, SK; Morris, SA; Podolny, V; Punna, T; Schuldiner, M; Strahl, BD; Thompson, NJ; Weissman, JS | 1 |
| Cramer, P; Sattler, M; Simon, B; Strahl, BD; Vojnic, E | 1 |
| Bartee, L; Bender, J; Ebbs, ML | 1 |
| Kane, AM; Macnaughtan, MA; Prestegard, JH | 1 |
| Adelman, K; Ardehali, MB; Lis, JT; Reinberg, D; Wei, W; Werner, J; Zhu, B | 1 |
| Brock, HW; Hess, JL; Martin, ME; Milne, TA; Slany, RK | 1 |
| Chruszcz, M; Clines, KL; Cymborowski, M; Flanagan, JF; Khorasanizadeh, S; Kim, Y; Mi, LZ; Minor, W; Rastinejad, F | 1 |
| Biron, VL; Heit, R; Hendzel, MJ; McManus, KJ; Underhill, DA | 1 |
| Han, YM; Kang, YK; Lee, KK; Yeo, S | 1 |
| Brown, EJ; Chen, YX; Hess, JL; Hua, X; Keeshan, K; Pear, WS; Silva, A; Tubbs, AT; Wang, H; Yan, J | 1 |
| Bedford, MT; Daniel, J; Espejo, A; Kim, J; Krishna, M; Lake, A; Xia, L; Zhang, Y | 1 |
| Cao, R; Martin, C; Zhang, Y | 1 |
| Bindila, L; Cepo, T; Cindrić, M; Skrlin, A; Vuletić, M | 1 |
| Duffy, JE; Tavassoli, A; Young, DW | 1 |
| Su, IH; Tarakhovsky, A | 1 |
| Bickmore, WA; Bloomfield, G; Chubb, JR; Ivens, A; Kaller, M; Kay, RR; Nellen, W; Shaulsky, G; Singer, RH; Skelton, J; Turner, BM; Xu, Q | 1 |
| Madden, BJ; Muddiman, DC; Zhang, Z; Zhou, H | 1 |
| Houston, SI; Magazinnik, T; Rice, JC; Sims, JK | 1 |
| Chin, HG; Estève, PO; Jacobsen, SE; Patnaik, D; Pradhan, S | 1 |
| Chen, ZJ; Lee, HS; Tian, L; Wang, J | 1 |
| Braun, RE; Payne, C | 1 |
| Baetz, K; Grimes, DE; Howe, L; Martin, DG | 1 |
| Chu, Y; Prelich, G; Sternglanz, R; Sutton, A | 1 |
| Angrand, PO; Vandamme, J | 1 |
| Chai, J; Deng, XW; Guo, L; Han, Z; Shen, Y; Wang, H | 1 |
| Bedford, MT; Fang, J; Huang, Y; Xu, RM; Zhang, Y | 1 |
| Farooq, A; Manzur, K; Qian, C; Wang, R; Wang, X; Zeng, L; Zhou, MM | 1 |
| Capo-chichi, CD; Caslini, C; Nicolas, E; Roland, IH; Xu, XX; Yeung, AT | 1 |
| Bhaumik, SR; Duan, Z; Sen, P; Shukla, A; Stanojevic, N | 1 |
| Bérubé, NG; Binné, UK; Dick, FA; Dyson, NJ; Erdmann, N; Francis, SM; Harrington, L; Isaac, CE; Julian, LM; Martens, AL; Seifried, LA; Sicinski, P | 1 |
| Casamitjana, R; Corominola, H; Gomis, R; Musri, MM; Párrizas, M | 1 |
| Fischle, W; Fritsch, C; Klymenko, T; Köcher, T; Müller, J; Papp, B; Schelder, M; Wild, B; Wilm, M | 1 |
| Dawe, RK; Shi, J | 1 |
| Reinberg, D; Trojer, P | 3 |
| Dobbie, IM; Grenon, M; Jimeno, S; Lowndes, NF; Maffini, S; O'Rorke, A; O'Shaughnessy, AM; Toh, GW | 1 |
| Bhaumik, SR; Duan, Z; Shadle, T; Shukla, A; Stanojevic, N | 1 |
| Terada, Y | 1 |
| Bartolini, B; Orsini, E; Ottani, V; Rossi, A; Ruggeri, A; Sonaggere, M; Tenni, R; Tira, ME; Viola, M | 1 |
| Bowden, EF; Xu, J | 1 |
| Ayer, DE; Cairns, BR; Carney, D; Cayrou, C; Chua, KF; Côté, J; Davrazou, F; Ewalt, M; Gozani, O; Hong, T; Hung, T; Kaadige, MR; Kutateladze, TG; Lacoste, N; Lan, F; Michishita, E; Peña, P; Saha, A; Shi, X; Shi, Y; Walter, KL | 1 |
| Allis, CD; Badenhorst, P; Chait, BT; Kauer, M; Kwon, SY; Landry, J; Milne, TA; Swigut, T; Tackett, AJ; Wu, C; Wysocka, J; Xiao, H | 1 |
| Davrazou, F; Gozani, O; Kutateladze, TG; Peña, PV; Shi, X; Verkhusha, VV; Walter, KL; Zhao, R | 1 |
| Allis, CD; Duncan, EM; Ilin, S; Li, H; Patel, DJ; Wang, W; Wysocka, J | 1 |
| Berger, SL; Fraser, NW; Hollow, CM; Huang, J; Kent, JR; Placek, B; Whelan, KA; Zeng, PY | 1 |
| Bae, Y; Erdjument-Bromage, H; Klose, RJ; Tempst, P; Wong, J; Yamane, K; Zhang, D; Zhang, Y | 1 |
| Agger, K; Antal, T; Christensen, J; Cloos, PA; Hansen, KH; Helin, K; Maiolica, A; Rappsilber, J | 1 |
| Fodor, BD; Jenuwein, T; Kubicek, S; Mechtler, K; O'Sullivan, RJ; Opravil, S; Perez-Burgos, L; Schotta, G; Sengupta, R; Yonezawa, M | 1 |
| Shilatifard, A | 2 |
| Barlev, NA; Morgunkova, A | 1 |
| Hirai, A; Nakazono, M; Saika, H; Tsuji, H; Tsutsumi, N | 1 |
| Chàvez, S; Couprie, J; Dehé, PM; Géli, V; Guérois, R; Leulliot, N; Luciano, P; Pamblanco, M; Quevillon-Cheruel, S; Rodriguez-Gil, A; Salah, P; Sollier, J; Tordera, V; Trésaugues, L; van Tilbeurgh, H; Varlet, I; Zinn-Justin, S | 1 |
| Lee, MG; McCafferty, DG; Schmidt, DM; Shiekhattar, R; Wynder, C | 1 |
| Bryk, M; Li, C; Mueller, JE | 1 |
| Hopkinson, AC; Ke, Y; Shek, PY; Siu, KW; Zhao, J | 1 |
| Becker, PB | 1 |
| Gilbert, DM; Singh, PB; Wu, R | 1 |
| Cosgrove, MS | 1 |
| Chen, H; Huang, N; Sun, Z; Xue, Y; Yao, X | 1 |
| Jenuwein, T | 1 |
| Allis, CD; Dou, Y; Lee, JW; Lee, S; Milne, TA; Roeder, RG; Ruthenburg, AJ; Verdine, GL | 1 |
| Müller, J; Papp, B | 1 |
| Bernstein, BE; Lee, JS; O'Donovan, A; Shilatifard, A; Steward, MM; Wyatt, M | 1 |
| Cross, GA; Hake, SB; Janzen, CJ; Lowell, JE | 1 |
| Angrand, PO; Völkel, P | 1 |
| Chávez, S; Dehé, PM; Dichtl, B; Géli, V; Landsberg, K; Lebrun, R; Mkandawire, M; Pamblanco, M; Rodríguez-Gil, A; Roguev, A; Rosaleny, LE; Schaft, D; Shevchenko, A; Stewart, AF; Tordera, V | 1 |
| Baetz, K; Gozani, O; Hieter, P; Howe, L; MacDonald, VE; Martin, DG; Shi, X; Walter, KL; Wlodarski, MJ | 1 |
| Cabot, R; Lee, K; Machaty, Z; Sega, MF | 1 |
| Sommerville, J; Stewart, MD; Wong, J | 1 |
| Allali-Hassani, A; Arrowsmith, CH; Bochkarev, A; Loppnau, P; Martín, F; Min, J; Plotnikov, AN; Schuetz, A; Vedadi, M | 1 |
| Bainbridge, M; DeCoteau, JF; Dong, WF; Geyer, CR; Huang, S; Hull, A; Lowsky, R; Pastural, E; Pearson, D; Takahashi, N | 1 |
| Bishopp, A; Doonan, J; Goodrich, J; Jenuwein, T; Primavesi, L; Roberts, G; Schubert, D | 1 |
| Kouzarides, T; Nelson, CJ; Santos-Rosa, H | 1 |
| Brandt, A; Houghton-Larsen, J | 1 |
| Chen, H; Costa, M; Davidson, TL; Shinkai, Y; Yan, Y | 1 |
| Hughes, RM; Waters, ML | 1 |
| Clarke, S; Porras-Yakushi, TR; Whitelegge, JP | 1 |
| Aalen, RB; Fischer, A; Grini, PE; Johnsen, SS; Reuter, G; Sandvik, SV; Thorstensen, T | 1 |
| Ji, C; Li, L; Lo, A; Marcus, S | 1 |
| Blobel, GA; Sachdeva, MM; Vakoc, CR; Wang, H | 1 |
| Krüger, S; Mann, M; Wisniewski, JR; Zougman, A | 1 |
| Reinberg, D; Sims, RJ | 2 |
| Goday, C; Greciano, PG | 1 |
| Ballaré, C; Beato, M; Clausell, J; Jordan, A; Nacht, AS; Quiles, I; Subtil-Rodríguez, A; Vicent, GP | 1 |
| Bhaumik, SR; Dzuiba, T; Florens, L; Lee, JS; Schneider, J; Shilatifard, A; Shukla, A; Stanton, JD; Swanson, SK; Washburn, MP; Wood, A; Wyrick, J | 1 |
| Assenberg, R; Au, KF; Grimes, JM; Meier, C; Nettleship, JE; Owens, RJ; Ren, J; Stuart, DI; Verma, A; Walter, TS | 1 |
| Lee, MG; Norman, J; Shiekhattar, R; Wynder, C | 1 |
| Li, G; Reinberg, D; Sims, RJ; Trojer, P | 1 |
| Eberharter, A; Eskeland, R; Imhof, A | 1 |
| Ishimaru, T; Kayashima, T; Kinoshita, A; Kishino, T; Mapendano, CK; Masuzaki, H; Matsumoto, N; Mukai, T; Niikawa, N; Ohta, T; Soejima, H; Urano, T; Yamasaki-Ishizaki, Y; Yoshiura, K | 1 |
| Berger, SL; Dorsey, JA; Huang, J; Jenuwein, T; Kubicek, S; Opravil, S; Perez-Burgos, L; Placek, BJ; Richter, M; Sengupta, R | 1 |
| Ding, J; Dong, X; Du, J; Hao, Q; Huang, Q; Liu, Q; Sun, B; Xu, G; Zhang, P; Zhou, J | 1 |
| Burlingame, AL; Osés-Prieto, JA; Zhang, X | 1 |
| Bedford, MT; Briggs, SD; Chan, SM; Davrazou, F; Fingerman, IM; Gozani, O; Howe, L; Kachirskaia, I; Kuo, JH; Kutateladze, TG; Lake, A; Lugovskoy, AA; Martin, DG; Shi, X; Utz, PJ; Walter, KL | 1 |
| Fang, S; Kemper, JK; Miao, J; Ponugoti, B; Treuter, E; Xiang, L | 1 |
| Dean, A; Kiefer, CM; Kim, A | 1 |
| Hasegawa, A; Hosokawa, H; Kaneko, T; Kimura, F; Kimura, MY; Kitajiama, M; Miyazaki, M; Nakayama, T; Wang, CR; Yamashita, M | 1 |
| Madhani, HD; Tompa, R | 1 |
| Allis, CD; Diaz, RL; Garcia, BA; Hake, SB; Hunt, DF; Lieb, JD; Morris, SA; Rao, B; Shabanowitz, J; Strahl, BD | 1 |
| Botuyan, MV; Chen, J; Kim, JE; Lee, J; Mer, G; Thompson, JR; Ward, IM | 1 |
| Ben-Shushan, E; Bergman, Y; Cedar, H; Eden, E; Farkash, S; Hecht, M; Keshet, I; Reubinoff, BE; Schlesinger, Y; Simon, I; Straussman, R; Yakhini, Z; Zimmerman, J | 1 |
| Huq, MD; Khan, SA; Tsai, NP; Wei, LN | 1 |
| Janknecht, R; Shin, S | 1 |
| Harte, PJ; Kurzhals, RL; Stratton, CA; Tie, F | 1 |
| Jedrusik, MA; Schulze, E | 1 |
| Shi, Y; Whetstine, JR | 1 |
| Allis, CD; Ruthenburg, AJ; Wysocka, J | 1 |
| Sakaguchi, A; Steward, R | 1 |
| Druzhinina, M; Karachentsev, D; Steward, R | 1 |
| Albrecht, AM; Arat, A; Bostelman, LJ; Keller, AM; Thompson, JS | 1 |
| Corsini, L; Sattler, M | 1 |
| August, EM; Hickey, ER; Homon, CA; Jenuwein, T; Kelly, TA; Kowalski, JA; Kubicek, S; Mechtler, K; O'Sullivan, RJ; Rea, S; Teodoro, ML; Zhang, Q | 1 |
| Bedford, MT; Lake, AN | 1 |
| Bentley, DL; Cubberley, G; Kim, S; Schonewald, M; Seward, DJ; Tripet, B; Zhang, L | 1 |
| Collas, P; Dahl, JA; Freberg, CT; Timoskainen, S | 1 |
| Bayliss, P; Bonni, A; de la Torre-Ubieta, L; Huarte, M; Iwase, S; Lan, F; Qi, HH; Roberts, TM; Shi, Y; Whetstine, JR | 1 |
| Agger, K; Christensen, J; Cloos, PA; Hansen, KH; Helin, K; Pasini, D; Rappsilber, J; Rose, S; Salcini, AE; Sennels, L | 1 |
| Bongiorni, S; Pasqualini, B; Prantera, G; Singh, PB; Taranta, M | 1 |
| Kone, BC; Kuhl, D; Lang, F; Reisenauer, MR; Rieg, T; Vallon, V; Xia, X; Zhang, W | 1 |
| Choi, KM; Chung, YG; Han, JW; Heo, KN; Hong, SP; Jin, DI; Kang, JK; Kim, YK; Lee, HW; Lee, JH; Lee, SH; Park, CS; Park, KW; Seo, JS; Seol, JG; You, JS | 1 |
| Couture, JF; Dietzel, K; Dirk, LM; Flynn, EM; Houtz, RL; Trievel, RC | 1 |
| Miao, F; Natarajan, R; Riggs, AD; Wu, X; Yuan, YC; Zhang, L | 1 |
| Bracken, AP; Capillo, M; Hansen, JB; Helin, K; Pasini, D | 1 |
| Klose, RJ; Zhang, Y | 1 |
| Burlingame, AL; Chu, F; de la Cruz, CC; Narlikar, GJ; Panning, B; Racki, LR; Shokat, KM; Simon, MD | 1 |
| Eissenberg, JC; Ilvarsonn, A; Lee, MG; Schneider, J; Shiekhattar, R; Shilatifard, A | 1 |
| Erdjument-Bromage, H; Jones, RS; Klose, RJ; Lee, N; Tempst, P; Zhang, J; Zhang, Y | 1 |
| McCafferty, DG; Schmidt, DM | 1 |
| Bulloch, EM; Chen, CH; Freitas, MA; Hsu, PH; Huang, WC; Liao, CL; Lo, WS; Ren, C; Tsai, MD; Tu, S; Yang, L; Yu, HM | 1 |
| Erdjument-Bromage, H; Gardner, KE; Klose, RJ; Liang, G; Tempst, P; Zhang, Y | 1 |
| Cheng, X; Zhang, X | 1 |
| Capan, Y; DeLuca, PP; Faraj, J; Leung, KP; Na, DH | 1 |
| Hu, P; Wang, S; Zhang, Y | 1 |
| Brenkman, AB; Inagaki, A; Mulder, KW; Timmers, HT; van den Broek, NJ | 1 |
| Benshoff, ML; Hughes, RM; Waters, ML | 1 |
| Bernatavichute, YV; Clarenz, O; Cokus, S; Goodrich, J; Jacobsen, SE; Pellegrini, M; Zhang, X | 1 |
| Brandl, CJ; Genereaux, J; Hoke, SM; Liang, G; Mutiu, AI | 1 |
| Shogren-Knaak, MA | 1 |
| Wang, Y; Zou, Y | 1 |
| Fang, J; Hogan, GJ; Liang, G; Lieb, JD; Zhang, Y | 1 |
| Shinkai, Y; Ueda, J | 1 |
| Cho, YW; Copeland, TD; Dressler, GR; Ge, K; Guo, H; Guszczynski, T; Hong, S; Hong, T; Kalkum, M; Kim, D; Yu, H | 1 |
| Guo, H; Guo, HB | 1 |
| Huang, TH; Liu, JC; Plass, C; Potter, D; Smith, LT; Wang, SH; Wu, J; Wu, YZ | 1 |
| Buratowski, S; Kim, T | 2 |
| Buisine, N; Colot, V; Coupland, G; Farrona, S; Gagnot, S; Guillaume, E; Martienssen, RA; Martin-Magniette, ML; Roudier, F; Turck, F | 1 |
| Brenner, C; Fuks, F | 1 |
| Bhaumik, SR; Shukla, A | 1 |
| Katagiri, Z; Kawahashi, K; Kioussis, D; Kitajima, S; Tanaka, Y | 1 |
| Aki, N; Kage, H; Kitagawa, H; Nagase, T; Ohishi, N; Sano, A; Sugimoto, K; Takai, D; Yatomi, Y | 1 |
| Du, TT; Huang, QH | 1 |
| Buratowski, S; Huarte, M; Kim, T; Lan, F; Martienssen, RA; Shi, Y; Vaughn, MW; Zaratiegui, M | 1 |
| Baroux, C; Fuchs, J; Grossniklaus, U; Pecinka, A; Schubert, I | 1 |
| Aalen, RB; Lambertsson, A; Larsson, J; Stabell, M | 1 |
| Aldebert, D; Bastien, O; Belrhali, H; Cannella, D; Garin, J; Hakimi, MA; Kieffer, S; Sautel, CF; Tardieux, I | 1 |
| Elkabes, S; Grant, JE; Hu, J; Jain, MR; Li, H; Liu, T | 1 |
| Eisenman, RN; Secombe, J | 1 |
| Andrews, LG; Berletch, JB; Katiyar, SK; Liu, C; Love, WK; Tollefsbol, TO | 1 |
| Hayakawa, N; Hayakawa, T; Ishikawa, F; Nakayama, J; Ohtani, Y; Saito, M; Shinmyozu, K | 1 |
| Hughes, RM; Khorasanizadeh, S; Waters, ML; Wiggins, KR | 1 |
| Caperta, A; Carchilan, M; Costa-Nunes, P; Delgado, M; Houben, A; Jones, RN; Morais-Cecílio, L; Ribeiro, T; Viegas, W | 1 |
| Nozaki, M; Shinkai, Y; Tachibana, M; Takeda, N | 1 |
| Barton, M; Chen, L; Firozi, P; Templeton, NS | 1 |
| Komori, N; Matsumoto, H; Takemori, N; Thompson, JN; Yamamoto, MT | 1 |
| Chang, J; Cheng, C; Liu, ZJ; Ng, J; Perrett, S; Rao, Z; Rose, J; Shaw, N; Tempel, W; Wang, BC; Wang, XY | 1 |
| Auger, V; Behr, R; Di Sauro, A; Ferraroni-Aguiar, V; Godmann, M; Kimmins, S; Sette, C | 1 |
| Dirk, LM; Houtz, RL; Magnani, R; Mazarei, M; Nayak, NR | 1 |
| Bonenfant, D; Coulot, M; Mueller, DR; Schindler, P; Towbin, H; van Oostrum, J | 1 |
| Barlev, NA; Chuikov, S; Gizatullin, F; Herrera-Medina, EM; Ivanov, A; Ivanov, GS; Ivanova, T; Kurash, J; Rauscher, F; Reinberg, D | 1 |
| Anderson, SL; Jiang, L; Kelleher, NL; Ma, P; Mizzen, CA; Smith, JN | 1 |
| Kang, MJ; Kim, KW; Kwon, H; Kwon, SJ; Kwon, YK; Lee, K; Lim, JH | 1 |
| Gillespie, RF; Gudas, LJ | 1 |
| Jin, Y; Kitazono, AA; Rodriguez, AM; Stanton, JD; Wyrick, JJ | 1 |
| Tan, H; Wang, J; Wu, S; Zhao, ZK | 1 |
| Wilson, JR | 1 |
| Blus, BJ; Gaudin, V; Germann, S; Jacobsen, SE; Khorasanizadeh, S; Zhang, X | 1 |
| Alpatov, R; Cheng, X; Collins, RE; De Cegli, R; Gozani, O; Horton, JR; Lan, F; Shi, X; Shi, Y | 1 |
| Henkels, CH; Khorasanizadeh, S | 1 |
| Appella, E; Dutta, S; Gozani, O; Kachirskaia, I; Shi, X; Wang, EW; Wen, H; West, LE; Yamaguchi, H | 1 |
| Benevolenskaya, EV | 1 |
| Maxson, J; Mooney, A; Parker, K; Wiley, EA | 1 |
| Di Croce, L; Lee, MG; Norman, J; Reinberg, D; Shiekhattar, R; Trojer, P; Villa, R; Yan, KP | 1 |
| Cohen, A; Fraterman, S; Klymenko, T; Köcher, T; Müller, J; Nekrasov, M; Oktaba, K; Papp, B; Stunnenberg, HG; Wilm, M | 1 |
| Gao, S; Kou, Z; Wang, F; Zhang, Y | 1 |
| Bhadra, U; Jackson, DE; Mamatha, L; Pal-Bhadra, M; Park, PH; Shukla, SD | 1 |
| Chou, SD; Tomasi, TB | 1 |
| Alpatov, R; Bayliss, PE; Canaani, E; Chang, HY; Chen, S; Issaeva, I; Iwase, S; Lan, F; Rinn, JL; Roberts, TM; Shi, Y; Wang, JK; Whetstine, JR | 1 |
| Berger, SL; Edwards, C; Ingvarsdottir, K; Lee, JS; Lee, MG; Schultz, DC; Shiekhattar, R; Shilatifard, A | 1 |
| Al-Abdallat, A; Alvarez-Venegas, R; Avramova, Z; Ndamukong, I; Saleh, A | 1 |
| Baltissen, MP; Denissov, S; Mann, M; Mulder, KW; Pijnappel, WW; Stunnenberg, HG; Timmers, HT; van Schaik, FM; Varier, RA; Vermeulen, M | 1 |
| Amati, B; Bassi, C; Casadio, F; Cesaroni, M; Guccione, E; Lüscher, B; Martinato, F; Schuchlautz, H | 1 |
| Bähler, J; Green, RD; Kirmizis, A; Kouzarides, T; Mann, M; Penkett, CJ; Santos-Rosa, H; Singer, MA; Vermeulen, M | 1 |
| Shi, Y | 1 |
| Blobel, GA; Canaani, E; Gregory, GD; Nakamura, T; Patel, S; Rozovskaia, T; Vakoc, CR; Zheng, X | 1 |
| Chen, CD; Han, G; Lin, H; Xiang, Y; Xu, L; Zhu, Z | 1 |
| Dressler, GR; Kim, D; Levitan, I; Patel, SR | 1 |
| Li, K; Teng, LJ | 1 |
| Glass, CK; Hermanson, O; Jepsen, K; Kim, HJ; McEvilly, RJ; Rosenfeld, MG; Solum, D; Zhou, T | 1 |
| de Ayala Alonso, AG; Fischle, W; Grimm, C; Ly-Hartig, N; Müller, CW; Müller, J; Rybin, V; Steuerwald, U | 1 |
| Florens, L; Hernandez, N; Swanson, SK; Washburn, MP; Yuan, CC; Zhao, X | 1 |
| Benner, J; Carey, MF; Chin, HG; Estève, PO; Patnaik, D; Pradhan, M; Pradhan, S | 1 |
| Kelleher, NL; Mizzen, CA; Pesavento, JJ; Yang, H | 1 |
| Amazit, L; Karagianni, P; Qin, J; Wong, J | 1 |
| Morrison, Z; Wiencke, JK; Yeh, RF; Zheng, S | 1 |
| Dennis, ES; Finnegan, EJ | 1 |
| Kustatscher, G; Ladurner, AG | 1 |
| Cho, YW; Ge, K; Hong, S; Veenstra, TD; Yu, H; Yu, LR | 1 |
| Akiyama, T; Aoki, F; Inoue, A; Kageyama, S; Nagata, M; Ooga, M | 1 |
| Jones, RS | 1 |
| Furukawa, Y; Hamamoto, R; Kunizaki, M; Nagayasu, T; Nakamura, Y; Shibuya, M; Silva, FP; Yamaguchi, K | 1 |
| Bell, O; Bell, SP; Garza, D; Hild, M; Imhof, A; MacAlpine, DM; Peters, AH; Scharf, AN; Schübeler, D; Schwaiger, M; van Leeuwen, F; Wirbelauer, C; Zilbermann, F | 1 |
| Clarke, SH; Feng, J; Li, Z; Morse, HC; Qi, CF; Wang, H | 1 |
| Allali-Hassani, A; Arrowsmith, CH; Liu, Y; MacKenzie, F; Min, J; Nady, N; Ouyang, H; Qi, C; Vedadi, M | 1 |
| Gontijo, AM; Hernandez Rivas, R; Issar, N; Lopez-Rubio, JJ; Nunes, MC; Scherf, A | 1 |
| Carney, D; Champagne, KS; Cheung, P; Ciccone, DN; Gallardo, M; Gozani, O; Han, S; Ivanov, D; Kuo, AJ; Kutateladze, TG; Matthews, AG; Oettinger, MA; Ramón-Maiques, S; Shi, Y; Utz, PJ; Walter, KL; Yang, W | 1 |
| Birve, A; Chen, S; Rasmuson-Lestander, A | 1 |
| Chen, CF; Erdjument-Bromage, H; Lewis, BA; Manley, JL; Millhouse, S; Reinberg, D; Sims, RJ; Tempst, P | 1 |
| Allis, CD; Duncan, EM; Fischle, W; Li, H; Liang, L; Murakami-Ishibe, S; Patel, DJ; Wang, W | 1 |
| Chen, AP; Chen, CD; Han, G; Lin, H; Ma, Y; Peng, Z; Xiang, Y; Xu, B; Ye, X; Yu, Y; Zhu, Z | 1 |
| Dong, A; Renou, JP; Shen, WH; Soubigou-Taconnat, L; Steinmetz, A; Xu, L; Zhao, Z | 1 |
| Clayton, AL; Edmunds, JW; Mahadevan, LC | 1 |
| Herceg, Z; Julien, E; Murr, R; Sardet, C; Tardat, M | 1 |
| Altaf, M; Briggs, SD; Côté, J; Lacoste, N; Tan, S; Utley, RT | 1 |
| Brinkley, WR; Larionov, V; Masumoto, H; Nakano, M; Ohzeki, J; Okada, T; Yoda, K | 1 |
| Hishikawa, Y; Ikura, T; Ito, T; Kajitani, T; Koji, T; Masuko, N; Matsuyama, T; Muramatsu, M; Nakagawa, T; Ohdan, H; Togo, S | 1 |
| Danker, T; Dreesen, B; Horst, I; Offermann, S; Peterhänsel, C | 1 |
| Dejaegere, A; Eberlin, A; Grauffel, C; Kimmins, S; Lambrot, R; Oulad-Abdelghani, M; Ponce-Perez, L; Robert, F; Schultz, P; Spehner, D; Stote, RH; Tora, L; Torres-Padilla, ME; Würtz, JM | 1 |
| Abbondanza, C; Avvedimento, EV; Bertoni, A; Chiariotti, L; Cuozzo, C; Malorni, A; Ombra, MN; Perillo, B; Sacchetti, S; Sasso, A | 1 |
| Nakayama, J; Sadaie, M; Shinmyozu, K | 1 |
| Fernando, M; O'Neill, LP; Spotswood, HT; Turner, BM | 1 |
| Goto, Y; Hayashi-Takanaka, Y; Kimura, H; Nozaki, N; Takizawa, N | 1 |
| Miao, F; Natarajan, R; Riggs, AD; Wu, X; Zhang, L | 1 |
| Azumi, Y; Cartagena, JA; Fujimoto, S; Fukui, K; Kurihara, D; Matsunaga, S; Seki, M; Shinozaki, K; Uchiyama, S; Yokoyama, M | 1 |
| Cross, GA; Janzen, CJ; Mandava, V | 1 |
| Cheng, X; Collins, RE; Horton, JR; Lee, DY; Northrop, JP; Stallcup, MR; Zhang, X | 1 |
| Fan, H; Gaudet, F; Granda, BW; Kurash, JK; Lei, H; Li, E; Marston, WL; Shen, Q; Wall, D | 1 |
| Ivanov, A; Margueron, R; Pirrotta, V; Reinberg, D; Sarma, K | 1 |
| Blobel, GA; Chen, J; Kim, JE; Lazar, MA; Lefterova, MI; Schupp, M; Steger, DJ; Stonestrom, AJ; Vakoc, AL; Vakoc, CR; Ying, L; Zhuo, D | 1 |
| Alkhalil, A; Chao, CC; Ching, WM; Wang, H; Zhang, Z | 1 |
| Armstrong, L; Atkinson, SP; Clelland, GK; Dunham, I; Fowler, JC; Koch, CM; Lako, M; Stewart, R; Willcox, S | 1 |
| Cryderman, DE; Kelleher, NL; Mizzen, CA; Pesavento, JJ; Starnes, TW; Wallrath, LL; Yang, H | 1 |
| Cui, L; Fan, Q; Miao, J | 1 |
| Honda, K; Iba, H; Kayama, H; Kuwata, H; Matsumoto, M; Mizutani, T; Ramirez-Carrozzi, VR; Smale, ST; Takeda, K; Yamamoto, M | 1 |
| Brent, MM; Marmorstein, R | 1 |
| Berger, SL; Huang, J | 1 |
| Lee, JT; Mekhoubad, S; Rowntree, RK; Silva, SS | 1 |
| Akhtar, A; Bell, O; Conrad, T; Kind, J; Schübeler, D; Wirbelauer, C | 1 |
| Ko, MS; Sharov, AA | 1 |
| Bourque, G; Chew, JL; Chiu, KP; Choo, A; Han, X; Kuznetsov, VA; Liu, J; Ng, HH; Oh, S; Orlov, YL; Ruan, Y; Shahab, A; Sung, WK; Wei, CL; Zhao, XD | 1 |
| Jonsdottir, GA; Nie, J; Pan, G; Ruotti, V; Stewart, R; Thomson, JA; Tian, S; Wei, H; Yang, C | 1 |
| Lee, J; Lee, JW; Lee, S; Lee, SK | 1 |
| Avramova, Z; Crevillen, P; Dean, C; Fleury, D; Grossniklaus, U; Inzé, D; Mylne, JS; Pien, S | 1 |
| Bruice, TC; Zhang, X | 2 |
| Chamberlain, SJ; Magnuson, T; Yee, D | 1 |
| Boccuni, P; Fischle, W; Gurvich, N; Hoya-Arias, R; Kalakonda, N; Macgrogan, D; Miyata, Y; Nimer, SD; Rice, JC; Sims, JK; Zhang, J; Zhao, X | 1 |
| Gaucher, SP; Keasling, JD; Mukhopadhyay, A; Redding, AM; Singh, AK | 1 |
| Goda, T; Mochizuki, K; Takabe, S | 1 |
| Chatterjee, C; Kim, J; McGinty, RK; Muir, TW; Roeder, RG | 1 |
| Cheng, X; Collins, RE; Jia, D; Kapoor-Vazirani, P; Peng, J; Powell, DR; Sharma, D; Subramanian, K; Vertino, PM | 1 |
| Dao, MC; Ferro, A; Janzen, V; Kharchenko, P; Lai, W; Orford, K; Park, PJ; Scadden, DT; Worhunsky, DJ | 1 |
| Gerstein, M; Hartman, S; Karpikov, A; Lian, J; Lian, Z; Mahajan, MC; Snyder, M; Weissman, SM | 1 |
| Lee, N; Zhang, Y | 1 |
| Berro, R; Easley, R; Flynn, EK; Kashanchi, F; Kehn-Hall, K; Klase, Z; Pedati, C; Symer, DE; Van Duyne, R; Wu, W | 1 |
| Bienz, M; Evans, P; Fiedler, M; Mieszczanek, J; Müller, J; Nekrasov, M; Rybin, V; Sánchez-Barrena, MJ | 1 |
| Fugmann, SD; Norton, DD; Wilson, DR | 1 |
| Bordignon, V; Godmann, M; Kimmins, S; Murphy, BD; Seneda, MM | 1 |
| Baniahmad, A; Goeman, F; Kyrylenko, S; Otto, K; Schmidt, O | 1 |
| Champagne, KS; Gozani, O; Hom, RA; Hung, T; Kuo, AJ; Kutateladze, TG; Li, G; Lin, H; Peña, PV; Subach, OM; Verkhusha, VV; Wong, RP; Zhao, R | 1 |
| Chuang, K; Edenberg, HJ; Fountain, M; Henderson, JT; Kandachar, V; Muir, WM; Ogas, J; Rider, SD; Romero-Severson, J; Simons, A; Zhang, H | 1 |
| Duro, E; Fuchs, SM; Kisseleva-Romanova, E; Kizer, KO; Mellor, J; Strahl, BD; Youdell, ML | 1 |
| Lanting, LL; Meng, L; Natarajan, R; Reddy, MA; Villeneuve, LM; Wang, M | 1 |
| Hartzog, GA; Quan, TK | 2 |
| Fleming, AB; Hillyer, C; Kao, CF; Osley, MA; Pikaart, M | 1 |
| Guo, J; Lee, JS; Schultz, PG; Wang, J | 1 |
| Iida, T; Moazed, D; Nakayama, J | 1 |
| Dokshin, GA; Donohoe, ME; Helin, K; Herman, H; Lee, JT; Lindroth, AM; McLean, CM; Miró, X; Park, YJ; Pasini, D; Persson, JM; Soloway, PD | 1 |
| Lanting, L; Natarajan, R; Reddy, MA; Villeneuve, LM; Wang, M | 1 |
| Kagey, JD; Kapoor-Vazirani, P; Powell, DR; Vertino, PM | 1 |
| Caron, C; De Robertis, C; Khochbin, S; Rousseaux, S; Wu, F | 1 |
| Allen, MD; Bycroft, M; Freund, SM; Jaulent, AM; Lechtenberg, BC; Santiveri, CM; Sathyamurthy, A | 1 |
| Benevolenskaya, EV; DeWaal, DC; Gupta, S; Holmes, KB; Kisiel, TA; Lopez-Bigas, N; Love, J; Murray, HL; Volkert, TL; Young, RA | 1 |
| Bar-Sela, G; Bisht, KS; Cui, H; Feinberg, AP; Gius, D; Kohn, E; Nguyen, P; Sun, L | 1 |
| Collas, P; Lindeman, LC; Noer, A | 1 |
| Bernatavichute, YV; Cokus, S; Jacobsen, SE; Pellegrini, M; Zhang, X | 2 |
| Ishida, J; Kawashima, M; Kim, JM; Kimura, H; Matsui, A; Morosawa, T; Seki, M; Shinozaki, K; To, TK; Toyoda, T | 1 |
| Ha, SG; Huq, MD; Wei, LN | 1 |
| Cibelli, JB; Iager, AE; Lopez-Corrales, N; Ragina, NP; Rodriguez, RM; Ross, PJ; Siripattarapravat, K | 1 |
| Bilenky, M; Birol, I; Cezard, T; Cullum, R; Euskirchen, G; Fejes, AP; Hirst, M; Hoodless, PA; Jones, SJ; Krzywinski, M; Marra, MA; Robertson, AG; Snyder, M; Tam, A; Thiessen, N; Wederell, ED; Zeng, T; Zhao, Y | 1 |
| Chodaparambil, JV; Hansen, JC; Lu, X; Luger, K; Shokat, KM; Simon, MD | 1 |
| Briggs, SD; Du, HN; Fingerman, IM | 2 |
| Goto, S; Ishigami, A; Kawakami, K; Nakamura, A; Takahashi, R | 1 |
| Akbarian, S; Huang, HS | 1 |
| Abraham, SJ; Gaponenko, V; Hoheisel, S | 1 |
| Arida, AR; Greeson, NT; Jenuwein, T; Sanders, SL; Sengupta, R | 1 |
| Florens, L; Lee, JS; Martin-Brown, S; Shilatifard, A; Wang, PF; Washburn, M; Wu, M | 1 |
| Appella, E; Gozani, O; Kachirskaia, I; Shi, X; Tanoue, K; Wang, EW; Wen, H; Yamaguchi, H | 1 |
| Kan, J; Liang, C; Wang, Z; Wu, R; Zhang, J; Zou, L | 1 |
| Dorighi, KM; Srinivasan, S; Tamkun, JW | 1 |
| Dagenais, TR; Keller, NP; Palmer, JM; Perrin, RM | 1 |
| Klose, RJ; Ng, SS; Oppermann, U; Yue, WW | 1 |
| Bracken, AP; Dietrich, N; Gehani, SS; Hansen, KH; Helin, K; Lerdrup, M; Monrad, A; Pasini, D; Rappsilber, J | 1 |
| Guo, J; Huang, B; Huang, H; Huang, W; Li, L; Lu, J; Tan, J | 1 |
| Chen, BH; Hsu, HS; Jin, JS; Lee, SC; Sun, GH; Tung, HJ; Tzao, C; Yu, CP | 1 |
| Frugier, M; Paulus, CA; Ryckelynck, M | 1 |
| Clarke, SG; Laganowsky, A; Webb, KJ; Whitelegge, JP | 1 |
| Armstrong, SA; Bracken, AP; Faber, J; Feng, Z; Jesneck, J; Krivtsov, AV; Kung, AL; Kutok, JL; Lemieux, ME; Silverman, LB; Sinha, AU; Vempati, S; Xia, X | 1 |
| Bailey, TL; Perkins, AC; Whitington, T | 1 |
| Bui, HT; Kim, JH; Kishigami, S; Van Thuan, N; Wakayama, S; Wakayama, T | 1 |
| Brehm, A; Imhof, A; Kremmer, E; Meier, K; Scharf, AN; Seitz, V | 1 |
| Ateeq, B; Brenner, JC; Cao, Q; Cao, X; Chinnaiyan, AM; Han, B; Jing, X; Kim, JH; Kumar-Sinha, C; Laxman, B; Lonigro, RJ; Maher, CA; Mani, RS; Palanisamy, N; Ramnarayanan, K; Shankar, S; Tan, P; Varambally, S; Wang, X; Yu, J | 1 |
| Cho, Y; Kim, A; Kim, K; Lee, CH; Rentoft, M | 1 |
| Kang, TJ; Suga, H; Yuzawa, S | 1 |
| Fujiwara, Y; Hsu, YJ; Kim, J; Liu, Y; Mao, X; Orkin, SH; Shen, X; Yuan, GC | 1 |
| Aszodi, A; Barlow, DP; Huang, R; Jenuwein, T; Koerner, MV; Pauler, FM; Regha, K; Sloane, MA; Sommer, A; Tamir, I | 1 |
| Elgin, SC; Wallrath, LL | 1 |
| Grunstein, M; Houseley, J; Rubbi, L; Tollervey, D; Vogelauer, M | 1 |
| Abmayr, SM; Florens, L; Li, B; Lin, CH; Swanson, S; Washburn, MP; Workman, JL; Zhang, Y | 1 |
| Barretina, J; Chang, B; Elledge, SJ; Howley, PM; Liu, J; Macia, E; Mulligan, P; Ottinger, M; Pavlova, N; Shi, Y; Shi, YJ; Westbrook, TF | 1 |
| Fujiyama, S; Ito, S; Kato, S; Kimura, S; Kouzmenko, AP; Li, F; Matsukawa, H; Murata, T; Sawatsubashi, S; Shirode, Y; Suzuki, E; Tabata, T; Takeyama, K; Tanabe, M; Ueda, T; Yamagata, K; Zhao, Y | 1 |
| Choi, YL; Isomura, T; Kaneda, R; Mano, H; Misawa, Y; Nonaka-Sarukawa, M; Shimada, K; Soda, M; Takada, S; Yamashita, Y | 1 |
| Bonfils, S; Borde, V; Géli, V; Lin, W; Nicolas, A; Robine, N | 1 |
| Li, Z; Yang, N | 1 |
| Jin, Y; Rodriguez, AM; Wyrick, JJ | 1 |
| Bush, MF; Oomens, J; Williams, ER | 1 |
| Fleharty, B; Gogol, M; Jackson, J; Li, B; Seidel, C; Shilatifard, A; Simon, MD; Workman, JL | 1 |
| Chaudhuri, S; Smerdon, MJ; Wyrick, JJ | 1 |
| Ahringer, J; Down, T; Kolasinska-Zwierz, P; Latorre, I; Liu, T; Liu, XS | 1 |
| Davidson, NE; Shaw, PG; Zhou, Q | 1 |
| Barcelona, H; Ha, SG; Huq, MD; Wei, LN | 1 |
| Chu, J; Heard, E; Murphy, N; Oda, H; Okamoto, I; Price, SM; Reinberg, D; Shen, MM; Torres-Padilla, ME | 1 |
| Adams-Cioaba, MA; Allali-Hassani, A; Amaya, MF; Arrowsmith, CH; Dong, A; Guo, Y; Min, J; Nady, N; Pan, P; Qi, C; Read, RJ; Schapira, M; Vedadi, M; Zhu, H | 1 |
| Mizzen, CA; Yang, H | 1 |
| Jia, S; Noma, K; Reddy, B; Thompson, J; Wang, H; Wang, Y; Yates, JR | 1 |
| Chen, LF; Huang, B; Kelleher, NL; Lamb, A; Li, M; Yang, XD | 1 |
| Akslen, LA; Goldfinger, N; Halvorsen, OJ; Haukaas, SA; Jonassen, I; Kalland, KH; Ke, XS; Li, WC; Lin, B; Oyan, AM; Petersen, K; Qu, Y; Rostad, K; Rotter, V | 1 |
| Chang, WC; Horng, JT; Hsu, JB; Hsu, PC; Huang, HD; Lee, TY; Shien, DM; Wang, TY | 1 |
| Cheedipudi, S; Dhawan, J; Kandalla, P; Pavlath, GK; Sambasivan, R; Sebastian, S; Sreenivas, P | 1 |
| Delgadillo, DM; Hernández-Cuevas, NA; Hernandez-Rivas, R; Mancio-Silva, L; Martínez-Calvillo, S; Pérez-Toledo, K; Rojas-Meza, AP; Scherf, A; Vargas, M | 1 |
| Baskind, HA; Geenen, DL; Ma, Q; Na, L; Patel, MP; Wang, QT | 1 |
| Absher, DM; Anton, E; Baker, JC; Brunner, AL; Chiao, E; Johnson, DS; Kim, SW; Medina, C; Myers, RM; Neff, NF; Nguyen, L; Oyolu, CB; Reddy, TE; Schroth, GP; Valouev, A | 1 |
| Andersson, R; Enroth, S; Komorowski, J; Påhlman, L; Rada-Iglesias, A; Wadelius, C; Wanders, A | 1 |
| Abraham, SJ; Gaponenko, V; Kobayashi, T; Solaro, RJ | 1 |
| Benner, J; Chin, HG; Estève, PO; Feehery, GR; Horwitz, GA; Jacobsen, SE; Pradhan, S; Samaranayake, M | 1 |
| Ngai, SM; Shao, J; Tsai, SN; Wang, Y; Xu, D | 1 |
| Schones, DE; Wang, Z; Zhao, K | 1 |
| Hashimoto, K; Horiguchi, K; Ishii, S; Mori, M; Okada, S; Satoh, T; Umezawa, R; Yamada, M | 1 |
| Ping, L; Wang, Y; Xiong, L; Yuan, B | 1 |
| Gupta, J; Kabra, DG; Tikoo, K | 1 |
| Hu, L; Qi, C; Zhu, YJ; Zhu, YT | 1 |
| Chen, S; Ding, X; Erdjument-Bromage, H; Long, C; Reinberg, D; Tempst, P; Xie, J; Yuan, W; Zheng, Y; Zhu, B | 1 |
| Botuyan, MV; Cui, G; Mer, G | 1 |
| Müller, J; Verrijzer, P | 1 |
| Masatsugu, T; Yamamoto, K | 1 |
| Bolck, HA; Guo, D; Kuo, MH; Xu, XJ | 1 |
| Job, G; Joshua-Tor, L; Kuscu, C; Noffsinger, VJ; Partridge, JF; Schalch, T; Shanker, S | 1 |
| Baldwin, KM; Bodell, PW; Haddad, F; Pandorf, CE; Wright, C | 1 |
| Arita, A; Costa, M; Li, Q; Sun, H; Zhou, X | 1 |
| Hansen, KH; Helin, K | 1 |
| Li, H; Moazed, D; Motamedi, MR; Patel, DJ; Walz, T; Wang, Z; Yip, CK | 1 |
| Chen, Y; Liu, P; Qiao, J; Sun, QY; Yan, J; Yan, LY | 1 |
| Chen, T; Nicholson, TB | 1 |
| Dhayalan, A; Jeltsch, A; Ma, H; Rathert, P | 1 |
| Florens, L; Lee, JS; Saraf, A; Shilatifard, A; Swanson, SK; Takahashi, YH; Trievel, RC; Washburn, MP | 1 |
| Booth, FW; Laye, MJ; Zwetsloot, KA | 1 |
| Battaglioli, E; Binda, C; Ciossani, G; Forneris, F; Karytinos, A; Mattevi, A; Profumo, A | 1 |
| Gourvennec, S; Morillon, A; Pinskaya, M | 1 |
| Albert, M; Hublitz, P; Peters, AH | 1 |
| Egorova, KS; Gvozdev, VA; Kalmykova, AI; Kibanov, MV; Olenina, LV; Olenkina, OM | 1 |
| Allis, CD; Casadio, F; Dormann, HL; Li, H; Luo, JL; Patel, DJ; Song, J; Wang, GG; Wang, Z | 1 |
| Goda, T; Mochizuki, K; Sakurai, N | 1 |
| Hixon, M; Moyer, B | 1 |
| Bizzaro, D; Bongiorni, S; Prantera, G; Pugnali, M; Singh, PB; Volpi, S | 1 |
| Hu, XZ; Jiang, H; Lipsky, RH; Marini, AM; Pan, H; Tian, F; Wu, X | 1 |
| Chen, T; Ciccone, DN | 1 |
| Ikawa, M; Kaneda, Y; Nimura, K; Okabe, M; Schwartz, RJ; Shiratori, H; Ura, K | 1 |
| Agrawal, A; Bilanchone, V; Dai, X; Gu, B; Lee, EY; Lewis, MT; Li, A; Li, B; Millar, S; Moraes, RC; Rhéaume, C; Sun, P; Takemaru, K; Teng, A; Veltmaat, JM; Yuan, Y | 1 |
| Cruz, P; Kone, BC; Li, S; Zhang, D | 1 |
| Grimm, C; Lindner, D; Ly-Hartig, N; Matos, R; Müller, CW; Müller, J; Rybin, V; Steuerwald, U | 1 |
| Almouzni, G; Bonaldi, T; Dent, SY; Imhof, A; Loyola, A; Nakatani, Y; Quivy, JP; Roche, D; Tagami, H | 1 |
| Beezhold, K; Castranova, V; Chang, Q; Chen, F; Lu, Y; Rojanasakul, Y; Shi, X; Zhang, Y; Zhao, H | 1 |
| Hartzog, GA; Martens, JA | 1 |
| Brennan, DM; Cho, L; Hazen, SL; Tang, WH; Wang, Z | 1 |
| Beaudet, AL; Dindot, SV; Garcia, R; Person, R; Strivens, M | 1 |
| Agirre, E; Alló, M; Buggiano, V; Chabot, B; de la Mata, M; Elela, SA; Eyras, E; Fededa, JP; Klinck, R; Kornblihtt, AR; Petrillo, E; Plass, M; Schor, I | 1 |
| Bhinge, A; Christodoulakis, M; Chronis, C; Lea, NC; Mufti, GJ; Orr, SJ; Smith, AE; Thomas, NS; Twine, NA | 1 |
| Bebenek, M; Lu, A; Mann, M; Pudełko, M; Wiśniewski, JR; Ziółkowski, P; Zougman, A | 1 |
| Cosgrove, MS; Dharmarajan, V; Patel, A; Vought, VE | 1 |
| Albar, JP; Alonso Guerrero, A; Barbero, JL; Buckle, M; Cano Gamero, M; Fütterer, A; Garcia-Gallo, M; Kouznetsova, A; Kremer, L; Leh, H; Leonardo, E; Martínez-A, C; Pacios-Bras, C; Prieto, I; Roncal, F; Serrano, A; Trachana, V; van Wely, KH | 1 |
| Jia, S; Wang, Y | 1 |
| Shilatifard, A; Trievel, RC | 1 |
| Brockdorff, N; Chow, JC; Denissov, S; Françoijs, KJ; Heard, E; Marks, H; Stunnenberg, HG | 1 |
| Dreijerink, KM; Höppener, JW; Jeninga, EH; Kalkhoven, E; Kummer, JA; Lips, CJ; Timmers, HT; van Beekum, O; Varier, RA | 1 |
| Ammerer, G; Klopf, E; Mas, G; Paskova, L; Petryshyn, A; Posas, F; Schüller, C; Solé, C; Wintersberger, U | 1 |
| Morillon, A; Pinskaya, M | 1 |
| Lam, HM; Ngai, SM; Sun, SM; Tsai, SN; Wang, C; Wu, T; Yuan, T | 1 |
| Niwa, T; Shimazu, T; Takeshima, H; Ushijima, T; Yamashita, S | 1 |
| Gardner, JM; Haug, J; Hentrich, T; Jackson, J; Jaspersen, SL; Johnston, M; Kobor, MS; Nakanishi, S; Schulze, JM; Shilatifard, A | 1 |
| Chin, HG; Estève, PO; Jacobsen, SE; Pradhan, S | 1 |
| Chen, ES; Ernst, C; Turecki, G | 1 |
| Eissenberg, JC; Shilatifard, A | 1 |
| Alexander, T; Ge, K; Gogol, M; Guo, H; Krumlauf, R; Lin, C; Sanderson, BW; Seidel, C; Shilatifard, A; Smith, ER; Wang, P; Wiedemann, LM; Wu, M | 1 |
| Broekhuizen, R; Dreijerink, KM; Kummer, JA; Lips, CJ; Timmers, HT; Valk, GD; van der Wal, JE; van Nuland, R; Varier, RA | 1 |
| Jacob, Y; Michaels, SD | 1 |
| De Santa, F; Natoli, G; Testa, G | 1 |
| Hauser, AT; Heinke, R; Jung, M; Sippl, W; Spannhoff, A | 1 |
| Bubunenko, NA; Bustin, M; Correll, S; Grigoryev, S; Karpova, TS; Malicet, C; McNally, JG; Postnikov, Y; Rochman, M; Wincovitch, S; Wu, X | 1 |
| De Marco, V; Drury, WJ; Gamblin, SJ; Justin, N; Margueron, R; Martin, SR; Ohno, K; Pirrotta, V; Reinberg, D; Sharpe, ML; Son, J; Taylor, WR; Voigt, P | 1 |
| Cai, G; Chen, S; Jia, G; Li, H; Mao, Z; Sun, J; Wang, W; Wu, H; Xu, M; Yang, P; Yuan, W; Zhu, B | 1 |
| Chin, JW; Garcia Alai, MM; Kapadnis, PB; Neumann, H; Nguyen, DP | 1 |
| Falbo, KB; Shen, X | 1 |
| Mellor, J | 1 |
| DeSalle, R; Rosenfeld, JA; Xuan, Z | 1 |
| Gudkov, AV; Jackson, MW; Kandel, ES; Lu, T; Singhi, AD; Stark, GR; Yang, M; Zhang, Y | 1 |
| Fischle, W; Franz, H; Mosch, K; Soeroes, S; Urlaub, H | 1 |
| Florentin, A; Gaspan, O; Grafi, G; Granot, G; Granot, Y; Morgenstern, Y; Paul, LK; Sikron-Persi, N; Talwara, S | 1 |
| Cazzonelli, CI; Finnegan, EJ; Millar, T; Pogson, BJ | 1 |
| Dutt, S; Graves, K; Juszczynski, P; Manis, JP; Shipp, MA; Xu, R; Yan, Q | 1 |
| Cui, B; Gorovsky, MA; Wang, Z | 1 |
| Psathas, JN; Reese, JC; Tan, S; Zheng, S | 1 |
| Chen, LF; Lamb, A; Yang, XD | 1 |
| Adams-Cioaba, MA; Allali-Hassani, A; Amaya, MF; Dong, A; Eryilmaz, J; Mackenzie, F; Min, J; Pan, P; Vedadi, M | 1 |
| Dickman, MJ; Hung, ML; Snijders, AP; Wilson, SA | 1 |
| Daniel, R; Geary, K; Liang, Z; Litwin, S; Schowalter, M; Silvers, RM; Smith, JA | 1 |
| Braunschweig, T; Büttner, R; Ellinger, J; Gütgemann, I; Höller, T; Koch, LK; Kremmer, E; Lüscher, B; Magerl, C | 1 |
| Briggs, SD; Du, HN; Fingerman, IM; Mersman, DP; South, PF | 1 |
| Austin, CP; Bedford, MT; Espejo, A; Oppermann, U; Quinn, AM; Simeonov, A; Spannhoff, A | 1 |
| Izpisua Belmonte, JC; Stewart, S; Tsun, ZY | 1 |
| Hunter, RG; McCarthy, KJ; McEwen, BS; Milne, TA; Pfaff, DW | 1 |
| Beshara, CS; Daze, KD; Hof, F; Jones, CE; Lilgert, BJ | 1 |
| Garcia, BA; LeRoy, G; Levin, RS; Wingreen, NS; Xu, B; Zee, BM | 1 |
| Che, FY; Farmar, JG; Hogue Angeletti, R; Nika, H; Weiss, L | 1 |
| Bazhenov, VV; Born, R; Ehrlich, H; Fischer, C; Frolov, A; Hanke, T; Henle, T; Hoffmann, R; Langrock, T; Schwarzenbolz, U; Simon, P; Worch, H | 1 |
| Shilatifard, A; Takahashi, YH | 1 |
| Arrowsmith, CH; Frye, SV; Herold, JM; Janzen, WP; Kireev, DB; Senisterra, GA; Vedadi, M; Wigle, TJ | 1 |
| Alkemade, FE; DeRuiter, MC; Gittenberger-de Groot, AC; Goeman, JJ; Havekes, LM; Henneman, P; Hierck, BP; Scheerman, JA; van den Elsen, PJ; van Dijk, KW; van Munsteren, JC; van Vliet, P | 1 |
| Filion, GJ; van Steensel, B | 1 |
| Goda, T; Inamochi, Y; Ishii, T; Mochizuki, K; Nakayama, T; Osaki, A | 1 |
| Bokoch, MP; Choi, HJ; Fung, JJ; Kobilka, BK; Kobilka, TS; Liu, CW; Mueller, L; Nygaard, R; Pardo, L; Prosser, RS; Puglisi, JD; Rasmussen, SG; Rosenbaum, DM; Thian, FS; Weis, WI; Zou, Y | 1 |
| Covington, HE; Dietz, DM; Greengard, P; Haggarty, SJ; Hurd, YL; LaPlant, Q; Maze, I; Mechanic, M; Mouzon, E; Nestler, EJ; Neve, RL; Ren, Y; Renthal, W; Russo, SJ; Sampath, SC; Schaefer, A; Tarakhovsky, A | 1 |
| Cho, S; Jeong, YS; Kang, YK; Ko, Y; Park, JS | 1 |
| Aktas, T; Constam, DB; Jakobsson, J; Layard-Liesching, H; Maillard, PV; Marquis, J; Mesnard, D; Reynard, S; Rougemont, J; Rowe, HM; Spitz, F; Trono, D; Verp, S | 1 |
| Chance, MR; Gudkov, AV; Jackson, MW; Lu, T; Miyagi, M; Stark, GR; Wang, B; Yang, M | 1 |
| Bochar, DA; Menon, T; Thompson, BA; Yates, JA | 1 |
| Licht, JD; Martinez-Garcia, E | 1 |
| Berger, SL; Chuikov, S; Dorsey, J; Huang, J; Jenuwein, T; Reinberg, D; Zhang, X | 1 |
| Fan, Y; Joachimiak, A | 1 |
| Gasteiger, E; Pang, CN; Wilkins, MR | 1 |
| Briggs, SD; Du, HN | 1 |
| Carr, S; Inche, A; Khaire, N; La Thangue, NB; Munro, S | 1 |
| Friedman, N; Liu, CL; Radman-Livaja, M; Rando, OJ; Schreiber, SL | 1 |
| Andrews, RM; Bonhoure, N; Bruce, AW; Chiang, K; Cooper, JL; Dhami, P; Dillon, SC; Ellis, PD; Hall, A; Jim, JH; Langford, C; Vetrie, D | 1 |
| Chen, LF; Tajkhorshid, E; Yang, XD | 1 |
| Collas, P; Dahl, JA; Klungland, A; Reiner, AH; Wakayama, T | 1 |
| Bastian, PJ; Büttner, R; Ellinger, J; Hartmann, W; Hauser, S; Kahl, P; Mertens, C; Müller, SC; Rogenhofer, S; von Ruecker, A | 1 |
| Cuellar, ME; Ingerman, LA; Waters, ML | 1 |
| Blumenthal, RM; Cheng, X | 1 |
| Beisenherz-Huss, C; Buettner, R; Friedrichs, N; Greschik, H; Günther, T; Hoffmeyer, K; Imhof, A; Ji, S; Kahl, P; Kirfel, J; Kunowska, N; Metzger, E; Müller, JM; Patel, D; Schüle, R | 1 |
| Cosgrove, MS; Patel, A | 1 |
| Bhaumik, SR; Malik, S | 1 |
| Cho, H; Choi, HK; Kang, JS; Kim, BJ; Kim, ST; Seo, JH | 1 |
| Imam, F; Liu, XS; Regev, A; Rinn, J; Schier, AF; Vastenhouw, NL; Woods, IG; Zhang, Y | 1 |
| Aanes, H; Alestrom, P; Collas, P; Lindeman, LC; Mathavan, S; Winata, CL | 1 |
| Drogaris, P; Fitzgerald, JE; Le Blanc, JC; Lowndes, NF; Thibault, P; Verreault, A | 1 |
| Cross, GA; Siegel, TN; Wright, JR | 1 |
| Simon, MD | 1 |
| Bu, ZY; Ding, B; Dong, AW; Shen, WH; Yu, Y; Zhu, Y | 1 |
| Helin, K; Jensen, ON; Jung, HR; Malatesta, M; Olsson, L; Pasini, D; Porse, B; Skotte, J; Walfridsson, J; Willer, A; Wutz, A | 1 |
| Hsieh, CL; Hsieh, JC; Okitsu, CY | 1 |
| Balakrishnan, L; Gefroh, A; Milavetz, B | 1 |
| Amente, S; Avvedimento, EV; Bertoni, A; Lania, L; Majello, B; Morano, A | 1 |
| Bozdech, Z; Chaal, BK; Luah, YH; Ong, EZ | 1 |
| de Graaf, P; Fortschegger, K; Outchkourov, NS; Shiekhattar, R; Timmers, HT; van Schaik, FM | 1 |
| Akbarian, S; Cheung, I; Jiang, Y; Matevossian, A; Shulha, HP; Wang, J; Weng, Z | 1 |
| Dennis, ES; Greenup, AG; Hemming, MN; Oliver, SN; Sasani, S; Talbot, MJ; Trevaskis, B | 1 |
| Audouard, C; Breton, A; LE Bourhis, D; Lelièvre, JM; Vignon, X | 1 |
| Adhvaryu, KK; Selker, EU; Wang, Y; Xiong, L | 1 |
| Chandrasekharan, MB; Chen, YC; Huang, F; Sun, ZW | 1 |
| Dambacher, S; Hahn, M; Schotta, G | 1 |
| Nakayama, J; Sadaie, M; Shinmyozu, K; Shirai, A | 1 |
| Chang, PY; Cleary, ML; Gozani, O; Hom, RA; Kuo, A; Kutateladze, TG; Musselman, CA; Zhu, L | 1 |
| Cai, W; Delattre, M; Deng, H; Girton, J; Johansen, J; Johansen, KM; Lerach, S; Wang, C | 1 |
| Barkai, N; Sigal, N; Tirosh, I | 1 |
| Michaels, SD; Yu, X | 1 |
| Adrian, J; Albani, MC; Coupland, G; Farrona, S; Reimer, JJ; Turck, F | 1 |
| Albertini, V; Cangemi, R; Carbone, GM; Catapano, CV; Chiorino, G; Kunderfranco, P; Malek, A; Mello-Grand, M; Mensah, A; Pellini, S | 1 |
| Borchers, CH; Han, J | 1 |
| Hatano, A; Higashinakagawa, T; Matsumoto, M; Nakayama, KI | 1 |
| Kimmins, S; Lambrot, R | 1 |
| Agrawal-Singh, S; Becker, A; Berdel, WE; Disselhoff, C; Dugas, M; Ehninger, G; Hascher, A; Isken, F; Klein, HU; Koschmieder, S; McClelland, M; Müller, FU; Müller-Tidow, C; Schlenke, P; Schmitz, W; Seidl, M; Serve, H; Thiede, C; Thoennissen, N; Tickenbrock, L; Tschanter, P; Wang, Y; zur Stadt, U | 1 |
| Chordia, MD; Chruszcz, M; Joachimiak, A; Minor, W; Murzyn, K; Sledz, P; Zheng, H; Zimmerman, MD | 1 |
| Clarke, SG; Lipson, RS; Webb, KJ | 1 |
| Akerstrom, G; Andersson, R; Dumanski, JP; Enroth, S; Komorowski, J; Rada-Iglesias, A; Sandgren, J; Wadelius, C; Westin, G | 1 |
| Riemen, AJ; Waters, ML | 1 |
| Bartkuhn, M; Cavalcanti, MC; Paradowska, A; Pons-Kühnemann, J; Schuppe, HC; Steger, K; Steilmann, C; Weidner, W | 1 |
| Gil, J; Li, S; Mujtaba, S; Muñoz-Cabello, AM; Raguz, S; Walsh, MJ; Yap, KL; Zeng, L; Zhou, MM | 1 |
| Bommi, PV; Dimri, GP; Dimri, M; Khandekar, J; Sahasrabuddhe, AA | 1 |
| Dhayalan, A; Jeltsch, A; Jurkowska, RZ; Ragozin, S; Rajavelu, A; Rathert, P; Tamas, R | 1 |
| Banko, MR; Brunet, A; Gozani, O; Green, EM; Greer, EL; Han, S; Hauswirth, AG; Leeman, DS; Maro, GS; Maures, TJ | 1 |
| Brooks, K; Chia, K; Gabrielli, B; Warren, WD; Warrener, R | 1 |
| Cho, S; Kang, YK; Lee, D; Park, JS; Shin, ST | 1 |
| Chang, KH; Coleman, ML; Hopkinson, RJ; Kessler, BM; Kramer, HB; Mackeen, MM; Schofield, CJ | 1 |
| Bhagat, M; Chattopadhyay, P; Das, B; Das, P; Mehndiratta, M; Palanichamy, JK; Ramalingam, P; Sinha, S | 1 |
| Chen, J; Chen, L; Cross, B; Jenuwein, T; Koomen, J; Li, Z; Marine, JC; Smith, MA; Wright, KL; Yuan, ZM; Zwolinska, AK | 1 |
| Akbarian, S; Hock, H; Huang, HS; Mostoslavsky, R; Qin, J; Van Buren, D; Zhong, L | 1 |
| Baek, SH; Binda, O; Choi, HJ; Gozani, O; Hwang, D; Kim, B; Kim, IS; Kim, JH; Kim, JY; Kim, KI; Kim, M; Kim, Y; Lee, H; Lee, JM; Lee, JS; Semenza, GL; Seo, SB; Shin, HJ | 1 |
| Kontaki, H; Talianidis, I | 1 |
| Dangaria, SJ; Diekwisch, TG; Ito, Y; Luan, X | 1 |
| Ott, M; Pagans, S; Sakane, N; Schnölzer, M | 1 |
| Benoist, C; Kingston, RE; Koh, AS; Mathis, D | 1 |
| Andreu, D; Cabrales-Rico, A; de la Torre, BG; Díaz, D; Fernández-Reyes, M; Jiménez-Barbero, J; Rivas, L; Vallès-Miret, M | 1 |
| Bhattacharjee, A; Brizuela, L; Garcia, BA; Gonzales, M; Gordon, DB; Hu, GQ; Huarte, M; Lan, F; Lim, H; Ongusaha, PP; Qi, HH; Roberts, TM; Sarkissian, M; Shi, Y; Wang, Z; Yaghi, NK; Zhao, K | 1 |
| Aggarwal, AK; Benner, C; Desai, A; Dorrestein, PC; Garcia-Bassets, I; Gassmann, R; Glass, CK; Liu, W; Liu, WT; Ohgi, KA; Rosenfeld, MG; Tanasa, B; Tyurina, OV; Zhou, TY | 1 |
| Deal, RB; Henikoff, S | 2 |
| Chikanishi, T; Fujiki, R; Hashiba, W; Kato, S; Okuno, Y; Sekine, H; Yokoyama, A | 1 |
| Caro, E; Feng, S; Gutierrez, C; Hassel, C; Jacob, Y; Jacobsen, SE; Leblanc, C; Michaels, SD; Stroud, H; Zhuo, L | 1 |
| Egorova, KS; Olenina, LV; Olenkina, OM | 1 |
| Ma, D; Sheng, W | 1 |
| Bekiranov, S; Hoang, S; Mayo, MW; Xu, X | 1 |
| Blus, BJ; Chandra, V; Huang, P; Khorasanizadeh, S; Kim, D; Rastinejad, F | 1 |
| Chen, DF; Coleman, N; Fang, Y; Malik, MT; Marquez, VE; Rao, RC; Tchedre, KT | 1 |
| Brunzelle, JS; Couture, JF; Del Rizzo, PA; Dirk, LM; Houtz, RL; Roiko, MS; Strunk, BS; Trievel, RC | 1 |
| Bannister, AJ; Koch, M; Santenard, A; Tora, L; Torres-Padilla, ME; Ziegler-Birling, C | 1 |
| Jeong, K; Kim, H; Kwon, CS; Lee, D; Oh, S | 1 |
| Arida, AR; Phan, FP; Sanders, SL | 1 |
| Cai, J; Hu, S; Li, Z; Shen, Y; Wang, J; Wang, Z; Xiao, L; Yu, L | 1 |
| Chia, DJ; Rotwein, P | 1 |
| Balakrishnan, L; Milavetz, B | 1 |
| Agno, JE; Anastassiadis, K; Andreu-Vieyra, CV; Chen, R; Glaser, S; Matzuk, MM; Stewart, AF | 1 |
| Botting, CH; Paytubi, S; Talbot, P; White, MF | 1 |
| Chen, G; Du, Z; Wang, D; Xu, Y; Yu, X; Zhang, X; Zhang, Z; Zhao, M | 1 |
| Brown, EJ; Cheng, EH; Hsieh, JJ; Kumar, R; Liu, H; Pandita, TK; Takeda, S; Westergard, TD | 1 |
| Egelhofer, TA; Ercan, S; Kimura, H; Lieb, JD; Phippen, TM; Rechtsteiner, A; Strome, S; Takasaki, T; Wang, W | 1 |
| Bedford, MT; Galka, M; Huang, Z; Iberg, A; Jiang, X; Lajoie, G; Li, L; Li, SS; Liu, H; Voss, C; Wang, Z | 1 |
| Kim, DH; Sung, S | 2 |
| Carpenter, PB; Gardner, JE; Lucio-Eterovic, AK; Rice, JC; Singh, MM; Veerappan, CS | 1 |
| Chen, CY; Hu, GF; Matsuo, K; Nishioka, T; Sasaki, A; Shima, K; Tsuji, T; Yamamoto, D | 1 |
| Butter, F; Denissov, S; Eberl, HC; Hyman, AA; Lee, KK; Mann, M; Marks, H; Matarese, F; Olsen, JV; Stunnenberg, HG; Vermeulen, M | 1 |
| Chemlal, K; Debrie, AS; Desmet, R; Diesis, E; Drobecq, H; Hougardy, JM; Locht, C; Mascart, F; Melnyk, O; Rouanet, C | 1 |
| Agrawal-Singh, S; Christophersen, NS; Dietrich, N; Gehani, SS; Hansen, K; Helin, K | 1 |
| Appella, E; Gozani, O; Hayashi, R; Kutateladze, TG; Lachmi-Weiner, K; Roy, S; Shi, X; West, LE | 1 |
| Choukrallah, MA; Davidson, I; Jost, B; Krebs, A; Legras, S; Martianov, I; Rijkers, E; Sassone-Corsi, P; Van Ijcken, W; Ye, T | 1 |
| Andersen, IS; Barrand, S; Collas, P | 1 |
| Andreu, D; Bastos, M; Coutinho, A; De la Torre, BG; Feio, MJ; Rivas, L; Teixeira, V | 1 |
| Hehenberger, E; Hennig, L; Köhler, C; Roszak, P; Weinhofer, I | 1 |
| Cho, YJ; Koellhoffer, EC; Lemieux, ME; McKenna, ES; Orkin, SH; Pomeroy, SL; Roberts, CW; Shen, X; Wang, X; Wilson, BG | 1 |
| Aasland, R; De Marco, V; Gamblin, SJ; Justin, N | 1 |
| Armstrong, K; Gaughan, L; McCracken, SR; McEwan, IJ; Pestell, RG; Robson, CN; Shaheen, F; Stockley, J; Treumann, A; Wang, C; Wang, N; Watt, K | 1 |
| Hou, H; Yu, H | 1 |
| Dirk, LM; Houtz, RL; Magnani, R; Trievel, RC | 1 |
| Breiling, A; Croce, CM; de Souza Rocha Simonini, P; Diederichs, S; Gupta, N; Hoheisel, JD; Lyko, F; Malekpour, F; Malekpour, M; Mayer, D; Najmabadi, H; Omranipour, R; Riazalhosseini, Y; Sahin, O; Volinia, S; Youns, M | 1 |
| Godsey, S; Oyer, JA; Turker, MS; Yates, PA | 1 |
| Azorín, F; Batlle, M; Huertas, D; Marsellach, FX | 1 |
| Chin, JW; Garcia Alai, MM; Nguyen, DP; Virdee, S | 1 |
| Boehnke, M; Boyle, AP; Chines, PS; Collins, FS; Crawford, GE; Erdos, MR; Furey, TS; Margulies, EH; Parker, SC; Pearson, DS; Scott, LJ; Sethupathy, P; Song, L; Stitzel, ML; Welch, R | 1 |
| Hengshuo, L; Jazin, E; Kullander, K; Lu, L; Radomska, KJ; Reinius, B; Rosen, GD; Sandhu, KS; Shi, C; Williams, RW | 1 |
| Avramova, Z; Chen, H; Ding, Y; Fromm, M; Laczko, P; Ladunga, I; Liu, R; Malkaram, S; Riethoven, JJ; van Dijk, K; Xia, Y; Yang, J | 1 |
| Dressler, GR; Kim, D; Lefevre, GM; Patel, SR; Tessarollo, L | 1 |
| Creamer, KM; George, OL; Job, G; Partridge, JF; Shaban, A; Shanker, S | 1 |
| Bergeron, M; Drouin, S; Forest, A; Jacques, PÉ; Laramée, L; Robert, F | 1 |
| Broger, L; Bucher, E; Mathieu, O; Paszkowski, J; Tittel-Elmer, M; Vaillant, I | 1 |
| Kisliouk, T; Meiri, N; Yosefi, S | 1 |
| Adams-Cioaba, MA; Amaya, MF; Bian, C; Guo, Y; Lam, R; Min, J; Vedadi, M; Wasney, GA; Xu, C | 1 |
| Huang, K; Huang, TH; Huang, YW; Li, L; Liu, Y; Nephew, KP; Shen, C; Wang, G; Wang, Y | 1 |
| Copeland, RA; Knutson, SK; Kuntz, KW; Pollock, RM; Richon, VM; Scott, MP; Sneeringer, CJ | 1 |
| Creech, CC; Neumann, DM | 1 |
| An, L; Chance, MR; Chen, X; Dasgupta, M; Du, Y; Huang, J; Lu, T; Miyagi, M; Sears, N; Stark, GR; Wang, B; Wang, Q; Wang, Y; Wang, Z; Yang, J; Zhang, X | 1 |
| Nesterova, TB; Shevchenko, AI; Shilov, AG; Vandeberg, JL; Zakharova, IS; Zakian, SM | 1 |
| Carr, SM; Kessler, B; La Thangue, NB; Munro, S; Oppermann, U | 1 |
| Eisenman, RN; Greer, C; Li, L; Secombe, J | 1 |
| Brown, L; Larson, G; Lee, DH; Oates, N; Pfeifer, GP; Rauch, TA; Rivas, G; Singh, P; Spalla, A; Spalla, C; Szabó, PE; Tsai, SY | 1 |
| Beswick, P; Heightman, TD; Jadhav, A; Kawamura, A; King, ON; Klose, RJ; Li, XS; Maloney, DJ; Mott, BT; Ng, SS; Oppermann, U; Quinn, AM; Rai, G; Rose, NR; Sakurai, M; Schofield, CJ; Simeonov, A | 1 |
| Basrur, V; Cao, F; Chen, Y; Cierpicki, T; Dou, Y; Lei, M; Liu, Y | 1 |
| Andino, BE; Erhard, KF; Gomos-Klein, J; Harrow, F; Knirr, S; Kovalovsky, D; Ortiz, BD; Sant'Angelo, DB | 1 |
| Ji, ES; Kim, HS; Kim, JY; Kim, SY; Kim, YH; Lee, SK; Park, KH; Park, YM; Yoo, JS | 1 |
| Chen, YH; Hung, MC; Lai, CC; Lang, J; Li, LY; Lin, CY; Shi, B; Wei, Y; Yang, CC; Yang, JY; Yeh, SP | 1 |
| Armache, JP; Arnold, GJ; Beckmann, R; Berninghausen, O; Dönhöfer, A; Fröhlich, T; Márquez, V; Mikolajka, A; Sohmen, D; Thomm, M; Wilson, DN | 1 |
| Aida, M; Begum, NA; Honjo, T; Muramatsu, M; Stanlie, A | 1 |
| Allis, CD; Duncan, EM | 1 |
| Greengard, P; Schaefer, A; Tarakhovsky, A | 1 |
| Gellert, M; Grundy, GJ; Yang, W | 1 |
| Farina, A; Gurvich, N; Hurwitz, J; Menendez, S; Nimer, SD; Perna, F; Voza, F | 1 |
| Chang, Y; Cheng, X; Estève, PO; Feehery, GR; Horton, JR; Pradhan, S; Samaranayake, M; Upadhyay, AK | 1 |
| Lu, T; Stark, GR; Wang, Y | 1 |
| Dai, Y; Lu, J; Ou, Y; Peng, W; Wang, L; Zhang, L; Zhang, Y | 1 |
| Achille, NJ; Chang, MJ; Chou, CW; Hemenway, CS; Reisenauer, MR; Wu, H; Zeleznik-Le, NJ; Zhang, W | 1 |
| Bajpai, R; Brugmann, SA; Flynn, RA; Rada-Iglesias, A; Swigut, T; Wysocka, J | 1 |
| Aleström, P; Collas, P; Lindeman, LC; Mathavan, S; Reiner, AH | 1 |
| Dheur, S; Genier, S; Javerzat, JP; Saupe, SJ; Vazquez, S | 1 |
| Camoin, L; Kulyyassov, A; Lipinski, M; Moio, P; Ogryzko, V; Ramankulov, E; Vertut, D | 1 |
| Choi, YL; Hasegawa, H; Hayashi, T; Imaizumi, Y; Kamihira, S; Mano, H; Marquez, VE; Miyazaki, Y; Moriwaki, Y; Osaka, A; Sasaki, D; Tsukasaki, K; Yamada, Y; Yanagihara, K | 1 |
| Chen, X; Gardner, KE; Parra, MA; Strahl, BD; Zhou, L | 1 |
| Becker, KG; De, S; Pazin, MJ; Precht, P; Wood, WH; Wurster, AL | 1 |
| Hiraoka, Y; Osborne, EA; Rine, J | 1 |
| Izzo, A; Schneider, R | 1 |
| Benevolenskaya, EV; Islam, AB; Lopez-Bigas, N; Richter, WF | 1 |
| Ahn, J; Chatterjee, B; Kim, S; Knapczyk-Stwora, K; Ko, S; Song, CS | 1 |
| Buzas, DM; Finnegan, EJ; Helliwell, CA; Robertson, M | 1 |
| Dressler, GR; Patel, SR; Schwab, KR | 1 |
| Li, L; Li, Z; Nie, F; Wang, S | 1 |
| Beekman, R; Beverloo, HB; Palande, KK; Touw, IP; Valk, PJ; van der Meeren, LE | 1 |
| Yap, KL; Zhou, MM | 1 |
| Bergsagel, PL; Chesi, M; Fei, F; Lou, Z; Luo, K; Pei, H; Qin, Y; Wang, L; You, Z; Zhang, L | 1 |
| Feng, J; Maze, I; Nestler, EJ; Shen, L; Sun, H; Wilkinson, MB | 1 |
| Dong, YH; Gao, ZQ; Ji, CN; Li, LF; Liu, CP; Liu, Y; Su, XD; Xu, JH | 1 |
| Blanco, E; Carbonell, A; Corominas, M; Pérez-Lluch, S; Raha, D; Serras, F; Snyder, M | 1 |
| Bai, Y; Mei, P; Sun, Y; Wang, Y; Wu, J; Xie, Q; Yuan, Z; Zhang, Y | 1 |
| Brooks, CF; Croken, MM; Francia, ME; Gissot, M; Kim, K; Striepen, B | 1 |
| Chen, X; Zheng, B | 1 |
| Chen, S; Chen, X; Xiong, J; Xu, M; Zhu, B | 1 |
| Huang, S; Jiao, F; Ma, Q; Yan, H; Yan, Z; Zeng, F; Zeng, Y | 1 |
| Blahnik, KR; Costello, JF; Dou, L; Echipare, L; Farnham, PJ; Hirst, M; Iyengar, S; Korf, I; Marra, MA; O'Geen, H; Sanchez, E; Zhao, Y | 1 |
| Batsché, E; Muchardt, C; Rachez, C; Saint-André, V | 1 |
| Jung, YJ; Kang, Y; Kim, AJ; Kim, HK; Kim, KC; Park, JA | 1 |
| Choi, JK; Kim, SC | 1 |
| Arrowsmith, CH; Brown, PJ; Frye, SV; Gao, C; Herold, JM; Ingerman, LA; Janzen, WP; Jin, J; Kireev, DB; Korboukh, VK; Lam, R; Norris, JL; Senisterra, G; Tripathy, A; Vedadi, M; Wigle, TJ | 1 |
| Bock, I; Dhayalan, A; Dimitrova, E; Jeltsch, A; Kudithipudi, S; Ragozin, S; Tamas, R; Tattermusch, A | 1 |
| Chang, HY; Chen, Y; Corces-Zimmerman, R; Dekker, J; Flynn, RA; Gupta, RA; Helms, JA; Lajoie, BR; Lei, M; Liu, B; Protacio, A; Sanyal, A; Wang, KC; Wysocka, J; Yang, YW | 1 |
| Frye, S; Gao, C; Herold, JM; Kireev, D; Norris, JL; Wigle, T | 1 |
| Aday, AW; Lakshmanan, A; Lawson, ND; Wang, J; Zhu, LJ | 1 |
| Arndt, KM; Davis, CP; Tomson, BN; Warner, MH | 1 |
| Bi, X; Boeke, JD; Olsen, L; Yu, Q; Zhang, X | 1 |
| Anderson, HC; Crist, JD; Gardner, BM; Li, Y; Lu, Q; Rodova, M; Wang, J; Woodbury, BG; Yost, JG; Zhong, XB | 1 |
| Brick, K; Camerini-Otero, RD; Gregoretti, IV; Khil, P; Petukhova, GV; Smagulova, F | 1 |
| Beichmanis, S; Cremer, C; Cremer, T; Eick, D; Gunkel, M; Heidemann, M; Leonhardt, H; Markaki, Y; Neumann, J; Schermelleh, L | 1 |
| Imai, K; Ochiai, K | 1 |
| Armstrong, H; Bonneil, E; Drogaris, P; Festenstein, RJ; Guillemette, B; Hiragami-Hamada, K; Imhof, A; Lin, HH; Thibault, P; Verreault, A | 1 |
| Chang, Y; Cheng, X; Gozani, O; Horton, JR; Levy, D; Peng, J; Zhang, X | 1 |
| Bedet, C; Dunkelbarger, S; Korswagen, HC; Palladino, F; Rakotomalala, C; Robert, VJ; Simonet, T; Soete, G; Strome, S; Xiao, Y | 1 |
| Chaumeil, J; Gilbert, C; Graves, JA; Koina, E; Robinson, TJ; Waters, PD | 1 |
| Cai, YD; Hu, LL; Li, HP; Li, Z; Niu, S; Shi, XH; Wang, K | 1 |
| Chinnasamy, N; Hong, JA; Liu, F; Marquez, VE; Morgan, RA; Rao, M; Schrump, DS; Xi, S; Zhang, M; Zhang, Y | 1 |
| Aiwazian, J; Bauer, A; Bouwmeester, T; Bunker, RD; Chan, H; Faty, M; Fischle, W; Gu, J; Gut, H; Hess, D; Li, L; Lingaraju, GM; Ly-Hartig, N; Müller, J; Prusty, AB; Sack, R; Schmitges, FW; Stützer, A; Thomä, NH; Wirth, U; Zhao, K; Zhou, S | 1 |
| Asp, P; Blum, R; Bowman, C; Cheng, J; Dynlacht, BD; Kluger, Y; Micsinai, M; Parisi, F; Vethantham, V | 1 |
| Flockhart, DA; Huang, TH; Huang, Y; Li, L; Liu, Y; Nephew, KP; Shen, C; Skaar, TC; Teng, M; Wang, G; Wang, Y; Wang, Z; Yan, P; Zhao, Y | 1 |
| Hayashi-Takanaka, Y; Kainuma, T; Kimura, H; Kurumizaka, H; Nozaki, N; Shinkai, Y; Stasevich, TJ; Tachibana, M; Tsurimoto, T; Wakayama, T; Yamagata, K | 1 |
| Bártová, E; Kozubek, S; Legartová, S; Pacherník, J; Stixová, L; Sustáčková, G | 1 |
| Bai, Q; Du, Y; Hai, J; Hu, T; Jin, N; Shen, Y; Wang, F; Wang, Q; Yang, J; Yao, X | 1 |
| de Boer, L; Nguyen, LT; Vogel, HJ; Zaat, SA | 1 |
| Day, SM; Dressler, GR; Furspan, PB; Herron, TJ; Jalife, J; Jones, TA; Klos, M; Milstein, ML; Noujaim, SF; Patel, SR; Stein, AB | 1 |
| Blewitt, ME; Hilton, DJ; Majewski, IJ; Oshlack, A; Trounson, E; Wakefield, MJ; Willson, TA; Young, MD | 1 |
| Farrington, L; Hathcock, KS; Hodes, RJ; Ivanova, I; Livak, F; Selimyan, R; Sen, R; Tai, X; Williams, J | 1 |
| Bag, I; Bhadra, U; Boeke, J; Imhof, A; Kremmer, E; Pal-Bhadra, M; Ramaiah, MJ; Vetter, I | 1 |
| Brickner, JH; Cajigas, I; Ezhkova, E; Geng, F; Jia, P; Leung, A; Tansey, WP; Zhao, Z | 1 |
| Ahn, SH; Kwon, DW | 1 |
| Ardehali, MB; Caron, M; Kusch, T; Lis, JT; Mei, A; Zobeck, KL | 1 |
| Buratowski, S; Churchman, LS; Terzi, N; Vasiljeva, L; Weissman, J | 1 |
| Amaya, MF; Dombrovski, L; Lam, R; Min, J; Qiu, W; Tempel, W; Wang, Y; Wu, H; Xu, C; Zeng, H | 1 |
| Cande, WZ; Li, F; Martienssen, R | 1 |
| Liao, L; Lindner, DJ; Niu, X; Rini, B; Yan, Q; Yang, H; Zhang, T; Zhou, L; Zhou, M | 1 |
| Cai, MY; Guan, XY; Kong, LL; Kung, HF; Rao, HL; Tong, ZT; Wen, ZZ; Xie, D; Zeng, YX; Zhu, W | 1 |
| Dolfini, D; Gatta, R; Imbriano, C; Mantovani, R; Pavesi, G; Zambelli, F | 1 |
| Baker, J; Chuong, E; Gupta, R; Kim, SW; Oyolu, C; Wills, AE; Yoon, SJ | 1 |
| Armstrong, SA; Bernt, KM; Chesworth, R; Copeland, RA; Daigle, SR; Jin, L; Johnston, LD; Kung, AL; Kuntz, KW; Majer, CR; Moyer, MP; Olhava, EJ; Pollock, RM; Richon, VM; Scott, MP; Smith, JJ; Sneeringer, CJ; Song, J; Therkelsen, CA; Tseng, JC; Xiao, Y | 1 |
| Armstrong, SA; Bernt, KM; Bullinger, L; Daigle, A; Faber, J; Feng, Z; Krivtsov, AV; Kung, AL; Pollock, RM; Punt, N; Richon, VM; Sinha, AU; Vempati, S; Zhu, N | 1 |
| Beese-Sims, SE; Colaiácovo, MP; Nottke, AC; Pantalena, LF; Reinke, V; Shi, Y | 1 |
| Ciccia, A; Elledge, SJ; Hajdu, I; Lewis, SM | 1 |
| Andrade, J; Andrau, JC; Carmo-Fonseca, M; Carvalho, S; de Almeida, SF; Eick, D; Fenouil, R; Ferrier, P; Grosso, AR; Gut, I; Gut, M; Koch, F; Levezinho, H | 1 |
| Barral, S; Chantalat, S; Depaux, A; Dimitrov, S; Gérard, M; Héry, P; Thuret, JY | 1 |
| Andreu, D; de la Torre, BG; Díaz, MD; Fernández-Reyes, M; Jiménez-Barbero, J; Rivas, L | 1 |
| Hair, A; Heath, C; Ma, MK; West, AG | 1 |
| Arteaga-Salas, JM; David, R; Imhof, A; Mentele, E; Nicetto, D; Rupp, RA; Schneider, TD | 1 |
| Hitchler, MJ; Rice, JC | 1 |
| Denbow, CJ; Denbow, DM; Meiri, N; Xu, P | 1 |
| Gozani, O; West, LE | 1 |
| Borisova, BE; Fuchs, J; Jovtchev, G; Kuhlmann, M; Mette, MF; Schubert, I; Watanabe, K | 1 |
| Del Rizzo, PA; Trievel, RC | 2 |
| Zhou, BO; Zhou, JQ | 1 |
| Copeland, RA; Jin, L; Knutson, SK; Kuntz, KW; Pollock, RM; Richon, VM; Scott, MP; Wigle, TJ | 1 |
| Chen, H; Emkey, R; Fisch, T; Hierl, M; Lee, JH; Long, AM; Schwandner, R; Tang, J; Yakowec, P; Yu, V | 1 |
| Alhonen, L; Hyvönen, MT; Keinänen, TA; Khomutov, AR; Khomutov, M; Park, JH; Park, MH; Simonian, A; Vepsäläinen, J | 1 |
| Cheng, X; Horton, JR; Upadhyay, AK; Zhang, X | 1 |
| Bhatia, N; Lomberk, GA; Longley, BJ; Simpson, A; Urrutia, R; Xiao, TZ | 1 |
| Atadja, P; Dai, J; Gu, J; Li, E; Li, L; Lu, C; Luo, X; Wang, L; Zhang, H; Zhao, K; Zhou, S; Zhu, J | 1 |
| Dai, Z; Li, ZC; Zhou, X; Zou, XY | 1 |
| Badenes, ML; Conesa, A; Leida, C; Llácer, G; Ríos, G | 1 |
| Feitoza, L; Guerra, M | 1 |
| Erman, B; Gursoy, A; Keskin, O; Sanli, D | 1 |
| Li, J; Wei, H; Zhou, MM | 1 |
| Chakraborty, D; Islam, K; Luo, M | 1 |
| Chen, S; Chen, Z; Ding, X; Mao, Z; Wang, W; Xu, R; Zhang, H; Zhang, X; Zhu, B | 1 |
| Das, PM; Huynh, FC; Jones, FE; Mitra, D | 1 |
| Fischle, W; Grubmüller, H; Klingberg, R; Schwarzer, D; Seeliger, D; Soeroes, S | 1 |
| Csankovszki, G; Laughlin, E; Petty, E | 1 |
| Gui, B; Liang, J; Shang, Y; Xie, G; Yang, X; Zhang, D; Zhang, Y | 1 |
| Elf, S; Hsieh, JJ; Huang, G; Lee, J; Liu, Y; Menendez, S; Nimer, SD; Osato, M; Sashida, G; Tenen, DG; Wang, L; Xu, H; Yan, X; Yang, Y; Zhang, P; Zhang, Y; Zhao, X | 1 |
| Crombet, L; Li, J; Li, Z; Min, J; Pan, PW; Ruan, J; Tempel, W; Tong, Y; Xu, C; Zang, J | 1 |
| Abu-Farha, M; Butson, J; Couture, JF; Elisma, F; Figeys, D; Lanouette, S; Tremblay, V | 1 |
| Bansal, N; Dwarakanath, BS; Kadamb, R; Mittal, S; Saluja, D; Sharma, R; Vig, L | 1 |
| Davies, P; Funk, KE; Kuret, J; Liao, Z; Thomas, SN; Wan, Y; Yang, AJ | 1 |
| Beland, FA; Koturbash, I; Pogribny, IP; Simpson, NE | 1 |
| Eisert, RJ; Waters, ML | 1 |
| Khorasanizadeh, S | 1 |
| Chen, S; Wang, W; Xu, M; Zhu, B | 1 |
| Campbell, RE; Ding, Y; Ibraheem, A; Yap, H | 1 |
| Akaike, M; Imada, T; Kameda, Y; Masuda, M; Miyagi, Y; Morinaga, S; Nakamura, Y; Oshima, T; Sakuma, Y; Shiozawa, M; Tamagawa, H; Yoshihara, M | 1 |
| An, W; Jeong, KW; Kim, K; Situ, AJ; Stallcup, MR; Ulmer, TS | 1 |
| Berger, F; Holec, S | 1 |
| Ames, RS; Li, H; Xie, W | 1 |
| Chen, K; Cheung, P; Garcia, BA; Gozani, O; Kioi, M; Kuo, AJ; Lauring, J; Li, W; Park, BH; Shi, X; Xi, Y; Zee, BM | 1 |
| Burkhart, KB; Burton, NO; Kennedy, S | 1 |
| Drabløs, F; Håndstad, T; Rye, M; Sætrom, P | 1 |
| Fu, X; Huang, Z; Jia, Z; Liu, S; Ni, B; Song, J; Tang, J; Tang, Y; Tian, Y; Tian, Z; van Velkinburgh, JC; Wang, J; Wang, Q; Wu, Y; Yang, D; Zhang, Y; Zheng, Y | 1 |
| Dong, A; Feng, H; Gao, J; Jin, J; Mu, C; Shen, WH; Sui, P; Ye, S; Yu, Y | 1 |
| Lee, JT; Pinter, SF; Sadreyev, RI; Yildirim, E | 1 |
| Katagiri, Z; Kawahashi, K; Kioussis, D; Mahajan, M; Nakayama, Y; Tanaka, Y | 1 |
| Cyr, TD; Rosu-Myles, M; She, YM; Walrond, L | 1 |
| Nguyen, K; Santiago, C; Schapira, M | 1 |
| Li, G; Qiu, Y; Shi, Y; Tu, X; Wang, W; Wang, Y; Wu, J; Zhang, J; Zhang, W; Zhang, Z; Zhao, C | 1 |
| Batra, V; Devasagayam, TP | 1 |
| Akhoond, MR; Favaedi, R; Shahhoseini, M | 1 |
| Cheng, Z; Lu, Z; Volchenboum, SL; Zhao, Y | 1 |
| Kwan, YW; Lam, HM; Ngai, SM; Pi, EX; Sun, SM; Tsai, SN; Wu, T | 1 |
| Berven, FS; Mjaavatten, O; Nygaard, G; Selheim, F | 1 |
| Kim, JE; Kim, R; Kim, W; Park, G; Park, JW | 1 |
| Shi, X; Wen, H; Zhang, X | 1 |
| Li, H; Li, Y | 1 |
| Bharathy, N; Chung, TK; Gopinadhan, S; Kok, WK; Li, S; Ling, BM; Rao, VK; Sartorelli, V; Tan, YH; Taneja, R; Walsh, MJ | 1 |
| Ma, P; Montgomery, RL; Olson, EN; Pan, H; Schultz, RM | 1 |
| Goda, T; Ishihara, A; Mochizuki, K; Yamauchi, K | 1 |
| Fire, A; Gu, SG; Guang, S; Kennedy, S; Maniar, JM; Pak, J | 1 |
| Andresen, C; Chait, BT; Dobenecker, MW; Donlin, LT; Gregorio, CC; Jacobs, EY; Just, S; Kruger, M; Linke, WA; Pappas, CT; Rottbauer, W; Rudensky, E; Tarakhovsky, A; Unger, A; Voelkel, T; Zieseniss, A | 1 |
| Ebrahim-Habibi, A; Es-Haghi, A; Nemat-Gorgani, M; Shariatizi, S | 1 |
| Carpenter, PB; Wagner, EJ | 1 |
| Abraham, CG; Kulesza, CA | 1 |
| Kim, S; Kim, YS; Lou, MF; Paik, MK; Paik, WK | 1 |
| Eissenberg, JC | 1 |
| Canovas, S; Cibelli, JB; Ross, PJ | 1 |
| Chen, J; Dai, Y; Qi, S; Sui, W; Yang, M | 1 |
| Allen, KE; Brandt, M; Chen, SB; Creasy, CL; Della Pietra, A; Diaz, E; Dul, E; Ganji, G; Gilbert, SA; Graves, AP; Halsey, WS; Hughes, AM; Jiang, Y; Kruger, RG; McCabe, MT; Ott, HM; Pappalardi, MB; Schwartz, B; Smitheman, KN; Thrall, SH; Tummino, PJ | 1 |
| Garcia, BA; Gozani, O; Green, EM; Mas, G; Young, NL | 1 |
| Beck, DB; Oda, H; Reinberg, D; Shen, SS | 1 |
| Cole, PA; Cotter, RJ; Dancy, BC; Dancy, BM; Drury, WJ; Jelinek, CA; Majumdar, A; Ming, SA; Papazyan, R; Sun, Y; Taverna, SD | 1 |
| Cui, G; Hendzel, MJ; Mallette, FA; Mattiroli, F; Mer, G; Richard, S; Sixma, TK; Young, LC | 1 |
| Carey, MF; DiMaggio, PA; Garcia, BA; Grunstein, M; Song, C; York, A; Yu, Y; Zhang, Q | 1 |
| Ma, XD; Zhao, T | 1 |
| Chen, JK; Cheung, P; Gozani, O; Ishibe-Murakami, S; Kuo, AJ; Patel, DJ; Song, J; Yamazoe, S | 1 |
| Andrieu-Soler, C; Duménil, D; Dusanter-Fourt, I; Fontenay, M; Frisan, E; Laurent, B; Randrianarison-Huetz, V; Soler, E | 1 |
| Chen, H; Dong, MQ; Hao, Y; Peng, S; Rao, C; Tao, L; Xie, Q; You, H; Yuan, Z | 1 |
| Huang, SY; Liang, RP; Qiu, JD; Shi, SP; Sun, XY; Suo, SB | 2 |
| Annan, R; Barbash, O; Garcia, BA; Gozani, O; Huddleston, M; Kruger, RG; Le, B; Liu, S; Mas, G; McDevitt, P; Reynoird, N; Sage, J; Sinnamon, R; Tummino, PJ; Van Aller, GS; Zmoos, AF | 1 |
| Bailey, KR; Beitelshees, AL; Boerwinkle, E; Burkley, B; Chapman, AB; Cooper-Dehoff, RM; Duarte, JD; Fillingim, RB; Gong, Y; Gums, JG; Johnson, JA; Kone, BC; Langaee, TY; Turner, ST; Zineh, I | 1 |
| Cong, R; Jia, Y; Li, R; Ni, Y; Parvizi, N; Sun, Q; Yang, X; Zhao, R | 1 |
| Druzd, D; Leipe, J; Ramming, A; Schulze-Koops, H; Skapenko, A | 1 |
| Hu, Y; Liu, D; Zhang, C; Zhang, Q; Zhong, X; Zhou, DX | 1 |
| Bishop, B; Muir, WM; Ogas, J; Ringenberg, W; Zhang, H | 1 |
| Goda, T; Mochizuki, K; Yamauchi, K | 1 |
| Bardag-Gorce, F; Buslon, V; French, BA; French, SW; Li, J; Oliva, J; Zhong, J | 1 |
| Blättler, SM; Chim, H; Cunningham, JT; Gygi, SP; Haas, W; Liu, H; Puigserver, P; Romanino, K; Rüegg, MA; Shi, Y; Verdeguer, F | 1 |
| Dave, N; Di Croce, L; Díaz, VM; García de Herreros, A; Gutierrez-Gallego, R; Herranz, N; Jerónimo, C; Lórenz-Fonfría, V; Millanes-Romero, A; Morey, L; Peiró, S | 1 |
| Berchtold, MW; Bumbuleviciute, R; Jacobsen, K; Kallerup, LK; Knudsen, KV; la Cour, JM; Olesen, UH; Panina, S; Sánchez-González, P; Stephan, A; Villalobo, A | 1 |
| Ishida, J; Kim, JM; Kimura, H; Matsui, A; Seki, M; To, TK | 1 |
| Bekei, B; Binolfi, A; Jost, JO; Liokatis, S; Rose, HM; Schwarzer, D; Selenko, P; Theillet, FX | 1 |
| Barré, P; Eliezer, D; Huster, D; Künze, G; Scheidt, HA; Thomas, L | 1 |
| Couttas, TA; Herbert, BR; Padula, MP; Raftery, MJ; Wilkins, MR | 1 |
| Zhu, WG | 1 |
| Akasu, T; Atomi, Y; Cho, HS; Dohmae, N; Field, HI; Hamamoto, R; Hayami, S; Iwai, Y; Kobayashi, T; Kogure, M; Maejima, K; Masuda, A; Nakamura, Y; Ohnuma, S; Ponder, BA; Sugiyama, M; Takawa, M; Toyokawa, G; Tsunoda, T; Ueda, K; Yamane, Y | 1 |
| Kawaguchi, A; Ochi, H; Ogino, H; Sudou, N | 1 |
| Chao, S; Gao, G; Jin, X; Li, J; Tang, H; Wang, G | 1 |
| Dhayalan, A; Jeltsch, A; Kebede, AF; Kudithipudi, S | 1 |
| Chubb, JR; Hsu, DW; Mahadevan, LC; Muramoto, T; Pears, CJ | 1 |
| Allis, CD; Fierz, B; Holt, M; Ito, T; McGinty, RK; Muir, TW; Whitcomb, SJ | 1 |
| Nishiuchi, Y; Shindo, H; Suzuki, R; Taichi, M; Tsuchiya, W; Yamazaki, T | 1 |
| Ernst, P; Vakoc, CR | 1 |
| De Luca, B; Donizetti, A; Fucci, L; Piscopo, M; Rana, G; Viggiano, E; Virelli, G | 1 |
| Gozani, O; Green, EM; Morrison, AJ | 1 |
| Liu, WR; Pai, PJ; Russell, DH; Russell, WK; Wang, YS; Wang, ZU | 1 |
| Bucci, D; Galeati, G; Porcu, E; Spinaci, M; Tamanini, C; Vallorani, C | 1 |
| Geng, YJ; Lei, HP; Li, Y; Liang, JL; Lin, QX; Lin, SG; Shan, ZX; Yu, XY; Zhang, S; Zhong, SL | 1 |
| Carr, SM; La Thangue, NB; Munro, S | 1 |
| Chatterjee, S; Kundu, TK; Senapati, P | 1 |
| Garcia, BA; Zee, BM | 1 |
| Bethel, C; De Marzo, AM; Gurel, B; Hicks, J; Iwata, T; Pellakuru, LG; Schultz, D; Yegnasubramanian, S | 1 |
| Chen, S; Gygi, SP; Li, X; Liu, XS; Lv, R; Ma, H; Ma, J; Shi, Y; Villen, J; Wu, F; Xiong, LJ; Xu, W | 1 |
| Borowsky, ML; Chapman, BA; Chen, CF; Glass, KC; Jin, Y; Kutateladze, TG; Matthews, AG; Oettinger, MA; Ohsumi, TK; Struhl, K; Yuan, CC | 1 |
| Inoue, K; Liu, YJ; Matoba, S; Nakamura, T; Nakano, T; Nakashima, H; Ogura, A; Shinkai, Y; Tachibana, M; Umehara, H | 1 |
| Bonanomi, D; Driscoll, S; Firth, A; Gifford, WD; Lettieri, K; Macfarlan, TS; Pfaff, SL; Rowe, HM; Singer, O; Trono, D | 1 |
| Daze, KD; Hof, F | 1 |
| Hentrich, T; Howe, L; Johnson, I; Kobor, MS; Maltby, VE; Martin, BJ; Schulze, JM; Sharma, A | 1 |
| Mücke, K; Nevels, M; Nitzsche, A; Paulus, C; Steinhäusser, C | 1 |
| He, Y; Mitra, A; Song, J; Sun, D; Wang, Y; Yu, Y; Zhang, S; Zhang, Y | 1 |
| Cui, P; Ding, F; Geng, J; Hu, S; Lin, Q; Liu, W; Song, S; Sun, F; Xin, C; Yu, J; Zhao, Y | 1 |
| Adenot, P; Aguirre-Lavin, T; Beaujean, N; Boulesteix, C; Brochard, V; Fleurot, R; Maalouf, WE; Ribeiro-Mason, K; Salvaing, J | 1 |
| Cabot, RA; Johnson, CM; Park, KE | 1 |
| Deng, NY; Ding, J; Huang, Q; Xu, Y | 1 |
| Coustham, V; Dean, C; Li, P; Lister, C; Song, J; Strange, A | 1 |
| Bonni, S; Chan, A; Deng, L; Eapen, SA; Netherton, SJ; Riabowol, K; Sarker, KP | 1 |
| Becker, S; Fischle, W; Gelato, KA; Klingberg, R; Kost, N; Munari, F; Rezaei-Ghaleh, N; Schomburg, A; Schröder, S; Schwarzer, D; Soeroes, S; Stützer, A; Walla, PJ; Zenn, HM; Zimmermann, B; Zweckstetter, M | 1 |
| Goda, T; Mochizuki, K; Shimada, M | 1 |
| Carr, SM; La Thangue, NB; Liu, G; Loftus, SJ; Munro, S | 1 |
| Bantscheff, M; Bountra, C; Bridges, A; Che, K; Cheng, Z; Chung, CW; Diallo, H; Drewes, G; Eberhard, D; Hutchinson, S; Joberty, G; Jones, E; Katso, R; Kruidenier, L; Lee, K; Leveridge, M; Liddle, J; Mander, PK; Mosley, J; Oppermann, U; Patel, DJ; Ramirez-Molina, C; Rowland, P; Schofield, CJ; Sheppard, RJ; Smith, JE; Swales, C; Tanner, R; Thomas, P; Tumber, A; Wilson, DM | 1 |
| Chang, S; Cui, K; Luo, J; Mitra, A; Song, J; Tian, F; Yu, Y; Zhang, H; Zhao, K | 1 |
| Bedford, MT; Kawabe, Y; McKinnell, IW; Rudnicki, MA; Wang, YX | 1 |
| Badeaux, AI; Bedford, MT; Botuyan, MV; Cheng, JQ; Cui, G; Kaneko, S; Kim, D; Lee, J; Mer, G; Park, S; Thompson, JR; Yan, F; Yuan, Z | 1 |
| Kelleher, NL; Licht, JD; Martinez-Garcia, E; Popovic, R; Sweet, SM; Thomas, PM; Tipton, JD; Zheng, Y | 1 |
| Noh, YS; Song, HR | 1 |
| Bogliotti, YS; Ross, PJ | 1 |
| Shokat, KM; Simon, MD | 1 |
| Gogol, MM; Kumar, S; Li, H; Natarajan, K; Saint, M; Smolle, M; Venkatesh, S; Workman, JL | 1 |
| Chai, J; Dai, C; Fu, H; Gao, S; Han, Z; Li, X; Liu, N; Niu, T; Wu, H; Wu, T; Xu, M; Yuan, W; Zhang, Z; Zhou, XJ; Zhu, B | 1 |
| Davydova, E; Egge-Jacobsen, W; Falnes, PØ; Jakobsson, M; Kernstock, S; Moen, A; Mælandsmo, GM; Pettersen, S | 1 |
| Chen, J; Liu, H; Ma, X; Wang, X; Wu, W; Xiong, K | 1 |
| Gupta, J; Krishna Murthy Karuturi, R; Kumar, S; Li, J; Tikoo, K | 1 |
| Díez, JL; Gorab, E; Madalena, CR | 1 |
| He, D; Li, Y; Liang, Q; Tan, T; Tao, W; Zong, L | 1 |
| Akaike, M; Kameda, Y; Miyagi, Y; Morinaga, S; Nakamura, Y; Numata, M; Ohkawa, S; Shiozawa, M; Tamagawa, H; Watanabe, T; Yamamoto, N | 1 |
| Bokoch, MP; Evanics, F; Larda, ST; Prosser, RS | 1 |
| Ait-Si-Ali, S; Ameyar-Zazoua, M; Andrau, JC; Batsché, E; Descostes, N; Fenouil, R; Fritsch, L; Hamiche, A; Harel-Bellan, A; Mathieu, J; Morozova, N; Muchardt, C; Rachez, C; Robin, P; Souidi, M; Young, R | 1 |
| Baumann, G; Dreger, H; Ludwig, A; Meiners, S; Stangl, K; Stangl, V; Weller, A | 1 |
| Chen, P; Huang, R; Huang, Y; Jiang, X; Jiang, Y; Li, M; Shi, R; Yang, X; Yao, J; Zheng, M; Zhu, B | 1 |
| Hu, J; Qian, Q; Wang, J; Xue, HW | 1 |
| Decarlo, D; Hadden, MK | 1 |
| Ikegami, D; Kim, YJ; Niwa, T; Takeshima, H; Ushijima, T; Wakabayashi, M | 1 |
| Brabletz, T; Bulut-Karslioglu, A; de la Rosa-Velazquez, IA; Gerle, B; Jenuwein, T; Lachner, M; Manke, T; Meidhof, S; Opravil, S; Pagani, M; Perrera, V; Popow, J; Scaranaro, M; Shukeir, N; van de Nobelen, S | 1 |
| Cho, HS; Daigo, Y; Field, HI; Hamamoto, R; Hayami, S; Ikawa, N; Ito, A; Maehara, Y; Masuda, K; Nakamura, Y; Ohnuma, S; Ponder, BA; Shimazu, T; Toyokawa, G; Tsuchiya, E; Yoshida, M | 1 |
| Kosten, J; Kriwacki, RW; Landrieu, I; Liokatis, S; Lippens, G; Selenko, P; Smet-Nocca, C; Theillet, FX; Thongwichian, R; Yoon, MK | 1 |
| Fuchter, MJ; Malmquist, NA; Mecheri, S; Moss, TA; Scherf, A | 1 |
| Barboni, B; Berardinelli, P; Bernabò, N; Curini, V; Di Giacinto, O; Martelli, A; Mattioli, M; Mauro, A; Nardinocchi, D; Russo, V | 1 |
| Allain, CJ; Chesworth, R; Copeland, RA; Jin, L; Keilhack, H; Klaus, CR; Knutson, SK; Kuntz, KW; Majer, CR; Moyer, MP; Olhava, EJ; Pollock, RM; Raimondi, A; Richon, VM; Sacks, JD; Scott, MP; Smith, JJ; Sneeringer, CJ; Song, J; Warholic, NM; Wigle, TJ | 1 |
| Baker, ME; Datson, NA; Dewell, S; Hunter, RG; McEwen, BS; Murakami, G; Pfaff, DW; Seligsohn, M | 1 |
| Chen, LH; Cheng, LY; Cherng, CG; Kao, GS; Su, CC; Tzeng, WY; Wang, CY; Yu, L | 1 |
| Barnstable, CJ; Berg, A; DeWan, AT; Hoh, J; Popova, EY; Salzberg, AC; Xu, X; Zhang, SS | 1 |
| Bloyer, S; Bouceba, T; Coléno-Costes, A; de Vanssay, A; Gibert, JM; Jang, SM; Le Crom, S; Mouchel-Vielh, E; Peronnet, F; Randsholt, NB; Rougeot, J | 1 |
| Casero, RA; Hanigan, CL; Jin, L; Park, BH; Wang, W; Woster, PM; Wu, Y | 1 |
| Rao, Z; Wang, M; Wang, W; Wang, Y; Xu, RM; Yang, N; Zhao, Q; Zhu, B | 1 |
| Bharathy, N; Gopal, P; Gopinadhan, S; Kok, WK; Ling, BM; Shankar, SR; Taneja, R; Wang, Y | 1 |
| Brind'Amour, J; Chruscicki, AT; Hentrich, T; Hills, M; Howe, LJ; Johnson, IJ; Kobor, MS; Lorincz, MC; Maltby, VE; Martin, BJ; McBurney, KL; Schulze, JM | 1 |
| Benevolenskaya, EV; Beshiri, ML; Gévry, N; Hess, S; Holmes, KB; Islam, AB; Kaelin, WG; Litovchick, L; Lopez-Bigas, N; Plante, L; Richter, WF; Yan, Q | 1 |
| Haraguchi, T; Hirano, Y; Hiraoka, Y; Hizume, K; Kimura, H; Takeyasu, K | 1 |
| Aimoto, S; Jayasinghe, CD; Kawakami, T; Kikugawa, Y; Kimura, H; Mishima, Y; Nishimura, O; Otani, J; Shirakawa, M; Suetake, I; Tajima, S; Watanabe, M | 1 |
| Cao, X; Cheng, Z; Cui, X; Gu, L; Guo, X; Jiang, L; Qin, R; Qiu, Y; Wan, J; Wang, D; Wang, H; Wang, JL; Wu, CY; Zhang, L; Zhang, X | 1 |
| Acquaviva, L; de La Roche Saint André, C; Dichtl, B; Dichtl, BS; Géli, V; Nicolas, A; Székvölgyi, L | 1 |
| Chen, F; Cheng, J; Fang, J; Li, Z; Wang, P; Xiao, J; Xu, Y; Yang, H; Yang, Y; Zhu, T | 1 |
| Huang, C; Xu, M; Zhu, B | 1 |
| Black, JC; Whetstine, JR | 1 |
| Baldridge, A; Ge, K; Grullon, S; Lee, JE; Peng, W; Wang, L; Xu, S | 1 |
| Croul, S; Dubuc, AM; Eberhart, CG; Hawkins, C; Hielscher, T; Jones, DT; Jones, SJ; Kool, M; Korshunov, A; Marra, MA; Mendez-Lago, M; Morrissy, AS; Northcott, PA; Peacock, J; Pfister, SM; Ramaswamy, V; Remke, M; Rolider, A; Rutka, JT; Shih, D; Taylor, MD; Unterberger, A; Vibhakar, R; Wang, X; Weiss, WA; Witt, H; Zhan, SH | 1 |
| Chen, PW; Li, H; Mellon, J; Niederkorn, JY; Sadegh, L | 1 |
| Asselin, C; Blais, M; Delabre, JF; Turgeon, N | 1 |
| Crona, F; Dahlberg, O; Larsson, J; Lundberg, LE; Mannervik, M | 1 |
| Black, JC; Van Rechem, C; Whetstine, JR | 1 |
| Gamal-Eldin, MA; Macartney, DH | 1 |
| Guan, Y; Hartlerode, AJ; Rajendran, A; Schotta, G; Scully, R; Shah, JV; Ura, K; Xie, A | 1 |
| Fujiwara, T; Fukada, H; Furuita, K; Hattori, Y; Ikegami, T; Kojima, C; Ohki, I; Shirakawa, M | 1 |
| Khaitova, LC; Malapeira, J; Mas, P | 1 |
| Dong, A; Gao, X; Shen, WH; Shi, J; Sui, P | 1 |
| Chen, S; Huang, X; Li, B; Li, X; Sun, F; Tang, N; Wang, X | 1 |
| Fischle, W | 1 |
| Dong, X; Engelhorn, J; Göbel, U; He, F; Reimer, J; Schoof, H; Turck, F | 1 |
| Barbera, AJ; Chen, F; Clark, EA; Dong, Z; Fang, J; Fang, R; Hu, D; Kaiser, UB; Kingston, RE; Li, J; Li, X; Li, Z; Lu, H; Marynick, MP; Mei, P; Rutenberg, M; Shi, YG; Simon, MD; Wang, P; Xu, Y; Yang, H; Yang, Y; Zhang, Y; Zhou, Q | 1 |
| Avgousti, DC; Cecere, G; Grishok, A | 1 |
| Allis, CD; Cai, L; Chen, WY; Lu, R; Patel, DJ; Rockowitz, S; Rothbart, SB; Song, J; Strahl, BD; Tripathy, A; Wang, GG; Xu, B; Zheng, D | 1 |
| Luo, N; Wang, J; Xu, X; Yin, M; Zhang, J; Zhang, W | 1 |
| Chait, BT; Foley, EA; Kapoor, TM; Kawashima, SA; Li, X; Li, Y; Molloy, KR | 1 |
| Björkholm, M; Claesson, HE; Fan, Y; Han, H; Liu, C; Schain, F; Sjöberg, J; Xu, D; Xu, Z | 1 |
| Fan, K; Li, Y; Li, Z; Liu, Y; Mackenzie, F; Min, J; Ouyang, H; Sun, X; Tu, X; Wang, T; Xu, C; Zhang, J; Zhang, X | 1 |
| Chen, M; Ideker, T; Licon, K; Otsuka, R; Pillus, L | 1 |
| Grinkevich, LN | 1 |
| Arita, K; Dohmae, N; Fukui, Y; Hamamoto, R; Iwai, Y; Masuda, A; Nakamura, Y; Sasaki, H; Shirakawa, M; Ueda, K; Unoki, M; Yoshimatsu, M | 1 |
| Cha, S; Jang, JH; Jong, JE; Seo, T | 1 |
| Gomez, D; Nguyen, AT; Owens, GK; Shankman, LS | 1 |
| Gozani, O; Hammell, M; Joshua-Tor, L; Kuo, A; McCombie, WR; Mills, AA; Paul, S; Schalch, T; Vogel, H | 1 |
| Bonaldi, T; Soldi, M | 1 |
| Berger, S; Blackburn, MR; Borok, Z; Chen, L; Jin, J; Li, JM; Liu, M; Wang, Y; Wu, H; Xia, Y; Xiao, Z; Yin, H; Zhang, W; Zhang, X; Zhou, B; Zhou, Q | 1 |
| Goda, T; Igarashi, M; Mochizuki, H; Mochizuki, K; Suruga, K; Takase, S | 1 |
| Jørgensen, S; Schotta, G; Sørensen, CS | 1 |
| Bao, Y; Chang, S; Li, H; Niu, B; Wu, L; Xue, P; Yang, F; Zhang, Q; Zhang, T | 1 |
| Acosta, I; Freire, R; Ontoso, D; San-Segundo, PA; van Leeuwen, F | 1 |
| Cao, W; Chen, HY; Cui, Y; Du, W; Fang, JY; Han, ZG; Hong, J; Lin, YW; Ren, LL; Shen, N; Sun, DF; Sun, TT; Wang, JL; Wang, YC; Wang, ZH; Weng, YR; Xiong, H; Xu, J; Yu, YN; Zou, W | 1 |
| Bussemer, S; Csankovszki, G; Hahn, M; Hake, SB; Jack, AP; Pünzeler, S; Schotta, G; Snyder, M; Solovei, I; Wells, M | 1 |
| Ferris, AL; Hughes, SH; Lauberth, SM; Nakayama, T; Roeder, RG; Tang, Z; Wu, X | 1 |
| Lukens, L; Zhan, S | 1 |
| Henikoff, S; Zentner, GE | 1 |
| Dedon, PC; Edrissi, B; Taghizadeh, K | 1 |
| Couture, JF; Skiniotis, G | 1 |
| El-Osta, A; Keating, ST | 1 |
| Dong, A; Feng, H; Shen, WH; Yao, X; Yu, Y | 1 |
| Acquaviva, L; de La Roche Saint-André, C; Dehé, PM; Drogat, J; Géli, V | 1 |
| Akaike, M; Kameda, Y; Masuda, M; Miyagi, Y; Morinaga, S; Nakamura, Y; Numata, M; Oshima, T; Rino, Y; Sakuma, Y; Shiozawa, M; Tamagawa, H; Yamamoto, N; Yoshihara, M; Yukawa, N | 1 |
| Jamieson, K; Lewis, ZA; Rountree, MR; Selker, EU; Stajich, JE | 1 |
| Allis, CD; Banaszynski, LA; Becher, OJ; Cordero, F; Garcia, BA; Koletsky, MS; Lewis, PW; Lin, S; Muir, TW; Müller, MM | 1 |
| Hieda, M; Higashi, S; Kimura, H; Matsumoto, A; Matsuura, N; Matsuura, S; Mori, M; Nishioka, Y; Yamamoto, H; Yokoyama, Y | 1 |
| Cho, EJ; Choi, A; Han, JW; Jang, H; Jo, CH; Kim, ST; Kim, YN; Lee, HY; Lee, J; Lim, J; Park, J; Song, TY; Song, Y; Yang, JH; Yang, YJ; Youn, HD | 1 |
| Camp, ND; Carlson, SM; Cheung, P; Chua, KF; Gozani, O; James, RG; Moore, KE; Wolf-Yadlin, A | 1 |
| Delgado, RN; Diaz, A; Gonzales-Roybal, G; Lim, DA; Nellore, A; Oldham, MC; Park, KY; Ramos, AD; Song, JS | 1 |
| Benitez, JJ; Cipriany, BR; Craighead, HG; Hagarman, JA; Ju, CY; Murphy, PJ; Soloway, PD; Szeto, K; Wallin, CB | 1 |
| Abe, K; Ikeda, M; Kawaguchi, H; Maeda, I; Matsui, Y; Mise, N; Noce, T; Okamura, D; Okuda, A; Tokitake, Y | 1 |
| Chen, J; Chen, S; Ding, L; Huang, H; Koller, A; Ma, Y; Sarver, A; Wang, L; Yu, J; Zeng, X; Zhao, JC; Zhi, J; Zhong, J | 1 |
| Corredor, E; Cuñado, N; Oliver, C; Pradillo, M | 1 |
| Binda, O | 1 |
| Chen, LF; Fletcher, JC; Kim, SY; Liu, MS; Pu, L; Sung, ZR | 1 |
| Arnaudo, AM; Cao, XJ; Garcia, BA | 1 |
| Balog, J; El Bouazzaoui, F; Eline Slagboom, P; Heijmans, BT; Henneman, P; Kremer, D; Putter, H; Schouten, SG; Thijssen, PE; Tobi, EW; van der Maarel, SM | 1 |
| Albertí, S; Barbier, M; Blázquez, J; Damron, FH; Goldberg, JB; Gomila, R; Martínez-Ramos, I; Owings, JP | 1 |
| Bjornson, RD; Breitbart, RE; Brown, KK; Brueckner, M; Carriero, NJ; Cheung, YH; Choi, M; Chung, WK; Deanfield, J; DePalma, S; Fakhro, KA; Gelb, BD; Glessner, J; Goldmuntz, E; Hakonarson, H; Italia, MJ; Jiang, J; Kaltman, JR; Kaski, J; Kim, R; Kline, JK; Lee, T; Leipzig, J; Lifton, RP; Lopez, A; Ma, L; Mane, SM; Mitchell, LE; Newburger, JW; Overton, JD; Parfenov, M; Pe'er, I; Porter, G; Roberts, AE; Romano-Adesman, A; Sachidanandam, R; Sanders, SJ; Seiden, HS; Seidman, CE; Seidman, JG; State, MW; Subramanian, S; Tikhonova, IR; Wakimoto, H; Wang, W; Warburton, D; White, PS; Williams, IA; Zaidi, S; Zhao, H | 1 |
| Ding, YH; Dong, MQ; Fu, Y; Fusser, M; He, C; Huang, CM; Jin, KX; Klungland, A; Li, MM; Liu, B; Lv, Y; Nilsen, A; Niu, Y; Olofsson, M; Rendtlew Danielsen, JM; Shi, Y; Wu, YS; Xu, XZ; Yang, YG | 1 |
| Copeland, RA; Hallenbeck, KK; Jin, L; Majer, CR; Moyer, MP; Scott, MP; Swalm, BM; Wigle, TJ | 1 |
| Kim, SY; Lee, I; Lee, RA; Lee, S; Noh, YS; Park, SK; Shin, K; Soh, MS; Song, HR | 1 |
| Chen, S; Cheng, YT; Huang, S; Jinn, TL; Jones, JD; Kamoun, S; Li, X; Soards, A; Win, J; Xia, S; Zhang, Y | 1 |
| Ghosh, S; Liu, B; Wang, Z; Zhang, L; Zheng, H; Zhou, Z | 1 |
| Cregan, SP; Dhami, GK; Galka, M; Kaneko, T; Li, L; Li, SS; Liu, H; Muranko, K; Voss, C; Wei, R | 1 |
| Benes, V; Carrieri, C; Comazzetto, S; De Fazio, S; Di Giacomo, M; Enright, AJ; Morgan, M; O'Carroll, D; Saini, H; Vasiliauskaite, L | 1 |
| Chen, B; Dhami, G; Galka, M; Lajoie, G; Li, SS; Li, X; Lin, YF; Liu, H; Liu, X; Miyaji, M; Mori, E; Pittock, P; Voss, C; Wei, R | 1 |
| Jackson, SP; Kaidi, A | 1 |
| Bleie, O; Borgeraas, H; Løland, KH; Nordrehaug, JE; Nygård, O; Strand, E; Svardal, A; Ueland, PM | 1 |
| Hendzel, MJ; McDonald, DW; Young, LC | 1 |
| Agresta, AM; Bonaldi, T; Bremang, M; Cuomo, A; Spadotto, V; Stugiewicz, M | 1 |
| El Maalouf, J; Lomonte, P; Sabra, M; Texier, P | 1 |
| Abraham, S; Chavan, TS; Gaponenko, V | 1 |
| Babinski, DJ; Best, AM; Brekken, RA; Bruick, R; Chang, J; Dellinger, M; Easmon, J; Frantz, DE; Kumar, S; Martinez, ED; Peña-Llopis, S; Quinn, AM; Ruiz, J; Simeonov, A; Varghese, D; Wang, L; Xu, J | 1 |
| Byun, HS; Choi, SW; Hong, JH; Huang, SM; Hur, GM; Jeon, J; Kim, JM; Kim, SH; Lee, JH; Lee, Y; Li, Y; Liu, ZG; Lu, T; Park, J; Park, KA; Ro, H; Shen, HM; Sohn, KC; Stark, GR; Zhang, T | 1 |
| Chase, KA; Gavin, DP; Guidotti, A; Sharma, RP | 1 |
| Luo, GZ; Teng, F; Tong, M; Wang, L; Wang, M; Wang, XJ; Zhang, Y; Zhao, X; Zhou, Q | 1 |
| Aravind, L; Bansal, A; Jiang, L; Jing, Q; Lavstsen, T; Luo, Y; Miller, LH; Mu, J; Ni, T; Peng, W; Rayavara, K; Ribeiro, JM; Scherf, A; Srinivasan, P; Theander, TG; Turner, L; Wakabayashi, Y; Wei, G; Yang, W; Zhang, Q; Zhao, K; Zhu, J | 1 |
| Akhtar, MM; Cocozza, S; Miele, G; Monticelli, A; Scala, G | 1 |
| He, W; Komives, E; Li, N; Stein, RS; Wang, W | 1 |
| Clausen, RP; Cloos, PA; Helgstrand, C; Kristensen, JB; Kristensen, JL; Leurs, U; Lohse, B | 1 |
| Iida, T; Kato, H; Murakami, Y; Nakayama, J; Okazaki, K; Urano, T | 1 |
| Krzycki, JA | 1 |
| Belles, X; Herraiz, A; Piulachs, MD | 1 |
| Bates, GP; Bodai, L; Finkbeiner, S; Fraenkel, E; Gipson, TA; Housman, DE; Krainc, D; Kratter, IH; Labadorf, A; Lau, A; Marsh, JL; Ng, CW; Ross, CA; Sadri-Vakili, G; Song, W; Thompson, LM; Troncosco, J; Vashishtha, M; Vogel-Ciernia, A; Yildirim, F | 1 |
| Gao, F; Gao, R; Guo, S; Liu, Y; Ma, Y; Shao, Y; Wu, F; Zhang, W; Zhao, Q; Zhu, L | 1 |
| Chang, C; Mercurio, AM; Pursell, B; Yang, X | 1 |
| Chen, X; Huang, H; Xu, L | 1 |
| Cai, T; He, XJ; Huang, HW; Jiang, L; Ma, ZY; Zhang, C; Zhang, FF; Zhou, HR; Zhu, JK | 1 |
| Gao, J; Qin, L; Wang, F; Wong, P | 1 |
| Dai, X; Dai, Z; Li, Q; Lian, S; Xiang, Q | 1 |
| Baas, R; Jansen, PW; Riss, A; Schram, AW; Timmers, HT; Tora, L; Vermeulen, M | 1 |
| Lodato, PM; Londoño Gentile, T; Lu, C; Olejniczak, SH; Thompson, CB; Tse, S; Wellen, KE; Witze, ES | 1 |
| Ghosh, G; Huang, DB; Lu, T; Ozer, GH; Stark, GR; Wei, H; Yang, M | 1 |
| Almeida, FC; Bezsonova, I; Cimprich, KA; Kile, AC; Korzhnev, DM; Machado, LE; Pozhidaeva, A; Pustovalova, Y | 1 |
| Coller, HA; Dyson, NJ; Evertts, AG; Garcia, BA; Manning, AL; Wang, X | 1 |
| Braszewska-Zalewska, AJ; Hasterok, R; Smialek, L; Wolny, EA | 1 |
| Allshire, RC; Castillo, AG; Catania, S; Choi, ES; Durand-Dubief, M; Ekwall, K; Hamilton, G; Pidoux, AL | 1 |
| Adamopoulos, C; Dalagiorgou, G; Gargalionis, A; Lea, RW; Papavassiliou, AG; Papavassiliou, KA; Piperi, C; Spyropoulou, A | 1 |
| Dillon, MB; Mowen, KA; Rust, HL; Thompson, PR | 1 |
| Dhayalan, A; Jeltsch, A; Kudithipudi, S; Kungulovski, G; Kycia, I; Tamas, R | 1 |
| Berthier, A; Jiménez-Sáinz, J; Pulido, R | 1 |
| Bueno, MT; Richard, S | 1 |
| Beck-Sickinger, AG; Huster, D; Kalkhof, S; Möbius, K; Nordsieck, K; Pichert, A; Samsonov, SA; Schiller, J; Teresa Pisabarro, M; Thomas, L | 1 |
| Achille, NJ; Birch, NW; Bushweller, JH; Kuntimaddi, A; Lokken, AA; Risner, LE; Schoenfelt, K; Zeleznik-Le, NJ | 1 |
| Patel, DJ; Wang, Z | 1 |
| Nakayashiki, H; Pham, KT; Vu, BV | 1 |
| Barco, A; Lopez-Atalaya, JP; Parkel, S | 1 |
| He, X; Wang, G; Zhang, K; Zhang, Y | 1 |
| Hadjiantoniou, A; Kirmizis, A; Kyriakou, D; Molina-Serrano, D; Schiza, V | 1 |
| Cho, EJ; Choi, J; Jang, H; Kim, H; Kim, ST; Lee, JH; Youn, HD | 1 |
| Dabrowski, M; Ellert-Miklaszewska, A; Hu, F; Kaminska, B; Kaza, B; Kettenmann, H; Kloss, M; Komorowski, J; Mieczkowski, J; Piotrowski, A; Przanowski, P; Ronowicz, A | 1 |
| Barton, MC; Jiang, Y; Li, J; Peng, D; Shi, X; Tanaka, K; Wen, H; Yan, J; Yang, Z; Zhang, X | 1 |
| Kauppi, L; Keeney, S; Ontoso, D; San-Segundo, PA | 1 |
| Cakouros, D; Cooper, L; Gronthos, S; Hemming, S; Isenmann, S; Menicanin, D; Zannettino, A | 1 |
| Aguiar, M; Beausoleil, SA; Bedford, MT; Comb, MJ; Gu, H; Guo, A; Jia, X; Kornhauser, J; Lee, KA; Mulhern, D; Ren, J; Silva, JC; Vemulapalli, V; Wang, Y; Yang, V; Zhou, J | 1 |
| Cao, X; Chen, Z; Fan, H; Gao, Y; Han, Q; Li, B; Lin, F; Nie, J; Qian, Z; Shan, Z; Sun, B; Tsun, A; Xu, K; Yin, S; Zhong, J; Zhou, X | 1 |
| Ahmed, S; Alvares, SM; Joyner, EY; Lakowski, B; Mayberry, GA | 1 |
| Kiguchi, N; Kishioka, S; Kobayashi, Y; Saika, F | 1 |
| Li, GM | 1 |
| Kumar, S; Maiti, S | 1 |
| Bowman, SK; Fang, R; Kesner, BA; Kingston, RE; Lee, JT; Maier, VK; Pinter, SF; Rutenberg-Schoenberg, M; Sarma, K; Simon, MD | 1 |
| El-Dahr, SS; McLaughlin, N; Saifudeen, Z; Wang, F | 1 |
| Chen, F; Lan, R; Liu, Y; Lu, F; Sun, H; Xu, Z; Ye, T; Yin, F; Zhang, H; Zhang, X; Zhu, L | 1 |
| Itoi, F; Li, C; Sato, E; Tanemura, K; Terashita, Y; Tokoro, M; Wakayama, S; Wakayama, T; Yamagata, K | 1 |
| Cosgrove, MS; Cotter, RJ; Dharmarajan, V; Howard, B; Kupakuwana, G; Monteith, KE; Namitz, KE; Patel, A; Shinsky, SA; Swatkoski, S; Viggiano, S; Vought, VE | 1 |
| Endo, TA; Handa, H; Higashimoto, K; Hirose, S; Komori, T; Koseki, H; Koseki, Y; Matsuda, M; Miyazaki, H; Nakayama, M; Nishioka, K; Sharif, J; Soejima, H; Yada, Y | 1 |
| Al-Hadid, Q; Bedford, MT; Clark, AT; Clarke, SG; Feng, Y; Hadjikyriacou, A; Li, Z; Maity, R; Masson, JY; Whitelegge, JP; Zurita-Lopez, C | 1 |
| Hennighausen, L; Kang, K; Robinson, GW; Yamaji, D; Yoo, KH | 1 |
| Chen, X; Cheng, S; Li, T; Liu, X; Zhao, Y; Zhong, X; Zhou, DX; Zhou, S | 1 |
| Chitalia, V; Costello, CE; Hartsough, EJ; Jiang, Y; Marquez, VE; Meyer, RD; Rahimi, N; Weinberg, J; Zhdanova, IV | 1 |
| Carlson, SM; Gozani, O; Green, EM; Martín, GM; Moore, KE | 1 |
| Baas, R; Castelijns, B; de Graaf, P; Egan, DA; Lelieveld, D; Lijnzaad, P; Timmers, HT; van Schaik, FM; van Teeffelen, H; Vermeulen, M | 1 |
| Casta, A; Christiano, AM; Kim, H; Kobayashi, Y; Liu, L; Shapiro, LS | 1 |
| Chen, JJ; Dai, Y; He, HY; Sui, WG; Yan, Q; Zhang, RH | 1 |
| Gouranton, E; Guex, N; Rotman, N; Wahli, W | 1 |
| Balwierz, P; Berninger, P; Ivanek, R; Karjalainen, K; Rolink, A; van Nimwegen, E; Vigano, MA | 1 |
| Andrews, PC; Gao, S; Liu, Y; Molascon, AJ; Zhang, C | 1 |
| Cook, M; Couture, JF; Gao, X; Jackson, J; Lee, JS; Morgan, MA; Shilatifard, A; Skiniotis, G; Smith, ER; Takahashi, YH; Thornton, JL; Westfield, GH; Woodfin, AR | 1 |
| Happel, N; Jeltsch, A; Kudithipudi, S; Lungu, C; Rathert, P | 1 |
| Chung, HH; Dong, XM; Lin, VC; Sim, KH; Sun, Y; Sze, SK; Woo, AR | 1 |
| Anastassiadis, K; Ciotta, G; Denissov, S; Hofemeister, H; Kranz, A; Marks, H; Singh, S; Stewart, AF; Stunnenberg, HG | 1 |
| Jung, M; Robaa, D; Sippl, W; Wagner, T | 1 |
| Coller, HA; Corney, DC | 1 |
| Arrigoni, G; Battistutta, R; Costa, R; Cozza, G; Izpisua Belmonte, JC; Lolli, G; Pinna, LA; Sarno, S | 1 |
| Berry, A; Donn, R; Farrow, SN; Hanley, N; Jangani, M; Matthews, L; Poolman, TM; Ray, DW; Whetton, AD; Williamson, AJ; Yang, N | 1 |
| Baron, J; Chen, W; Cheung, CS; Lui, JC | 1 |
| Abeykoon, A; Chao, CC; Ching, WM; Chock, PB; Gucek, M; Wang, G; Yang, DC | 1 |
| Fahrenkrog, B; Matter, A; Walter, D | 1 |
| Cui, X; Nenoi, M; Ninomiya, Y; Sekine-Suzuki, E; Wang, B; Yasuda, T; Yu, D | 1 |
| Fei, Z; Gapper, NE; Giovannoni, JJ; Nguyen, CV; Vrebalov, JT; Zheng, Y; Zhong, S | 1 |
| Chia, SZ; Hart-Smith, G; Low, JK; McKay, MJ; Molloy, MP; Wilkins, MR | 1 |
| Choi, M; Kim, JE; Kim, W | 1 |
| Kim, S; Lim, IK; Paik, WK | 1 |
| Chang, CW; Chang, TH; Cheng, TH; Lee, TY; Lu, CT | 1 |
| Klose, RJ; Rose, NR | 1 |
| Gozani, O; Moore, KE | 1 |
| Chujo, T; Scott, B | 1 |
| Allen, HF; Daze, KD; Hof, F; Kutateladze, TG; Lai, A; Musselman, CA; Shimbo, T; Sims, JK; Wade, PA | 1 |
| Kim, KS; Mukhopadhyay, A; Tian, XJ; Xing, J; Zhang, H | 1 |
| Bedford, MT; Gayatri, S | 1 |
| Peterson, CL; Swygert, SG | 1 |
| Barton, MC; Jiang, S; Li, B; Li, H; Li, W; Li, Y; Peng, D; Ren, Y; Shi, X; Stratton, S; Tanaka, K; Wen, H; Wu, J; Xi, Y; Xia, Z | 1 |
| Brunzelle, J; Holcomb, J; Jiang, Y; Shi, X; Sirinupong, N; Trescott, L; Yang, Z; Zhang, X | 1 |
| Shilatifard, A; Smith, E | 1 |
| Aburatani, H; Fukayama, M; Hayashi, A; Ishikawa, S; Kimura, H; Kokudo, N; Morikawa, T; Nagae, G; Nishi, A; Sakamoto, Y; Shibahara, J; Yamauchi, N | 1 |
| Abrescia, NG; Azkargorta, M; Elortza, F; Wojtas, MN | 1 |
| Strahl, BD; Wozniak, GG | 1 |
| Kusch, T; Mei, A; Nguyen, C | 1 |
| Donohoe, ME; Kamikawa, YF | 1 |
| Goodrich, J; Lee, E; Lucas, JR; Sack, FD | 1 |
| Bannister, AJ; Daujat, S; Di Cerbo, V; Feil, R; Feldmann, A; Hoerner, L; Holzner, M; Kacem, S; Kallis, E; Khochbin, S; Michaelis, J; Mittler, G; Mohn, F; Montellier, E; Owen-Hughes, T; Richter, FM; Ryan, DP; Schneider, R; Schuebeler, D; Tropberger, P | 1 |
| Almouzni, G; Gurard-Levin, ZA; Loyola, A; Rivera, C | 1 |
| Couture, JF; Figeys, D; Lanouette, S; Mongeon, V | 1 |
| Anandhakumar, J; Gao, L; Gross, DS; Zhang, H | 1 |
| Dohmae, N; Hamamoto, R; Kang, D; Masuda, A; Nakamura, Y; Piao, L; Suzuki, T | 1 |
| Khorasanizadeh, S; Kutateladze, TG; Musselman, CA | 1 |
| Leiter, AB; Li, HJ; Metzger, E; Ray, SK; Schüle, R | 1 |
| Antonarakis, SE; Bonilla, X; Borel, C; Chevalier, C; Deutsch, S; Falconnet, E; Farinelli, L; Feki, A; Gagnebin, M; Garieri, M; Gehrig, C; Gonzalez, D; Guigo, R; Guipponi, M; Herault, Y; Hibaoui, Y; Kind, J; Letourneau, A; Migliavacca, E; Popadin, K; Robyr, D; Sailani, MR; Sandstrom, RS; Santoni, FA; Stamatoyannopoulos, JA; Thurman, R; van Steensel, B; Vannier, A | 1 |
| Liu, D; Zempleni, J | 1 |
| Antolin-Fontes, B; Barnabé-Heider, F; Biswas, M; Cascante, A; Hermanson, O; Klum, S | 1 |
| Du, J; Patel, DJ | 1 |
| Alexe, G; Bradner, JE; Bustin, M; Chapuy, B; Crispino, JD; Day, TA; Hahn, WC; Harris, MH; Izraeli, S; Jaffe, JD; Lane, AA; Li, H; Lin, CY; Liu, H; Malinge, S; Neuberg, D; Pellman, D; Sallan, SE; Schinzel, AC; Silverman, LB; Stegmaier, K; Stevenson, KE; Sullivan, TJ; Taylor, JE; te Kronnie, G; Tivey, T; Townsend, EC; van Bodegom, D; Weinstock, DM; Wu, SC; Yoda, A | 1 |
| Alban, C; Brugière, S; Ferro, M; Gigarel, O; Gilgen, A; Ma, S; Martin-Laffon, J; Mazzoleni, M; Mininno, M; Ravanel, S; Tardif, M | 1 |
| An, J; Dong, W; Du, E; Hu, Y; Li, J; Liu, T; Pan, C; Qin, J; Wan, Y; Zeng, W; Zhang, X | 1 |
| Bierhoff, H; Brocks, D; Dambacher, S; Dammert, MA; Grummt, I; Schotta, G | 1 |
| Ji, B; Meng, C; Ren, H; Wang, H | 1 |
| Baker, MR; Banerjee, T; Barish, GD; Chakravarti, D; Kim, JY; Luo, Q; Parker, JB; Radhakrishnan, I; Vinckevicius, A; Wei, JJ | 1 |
| Gileadi, C; Hopkinson, RJ; Johansson, C; Madden, SK; Oppermann, U; Schofield, CJ; Vollmar, M; Walport, LJ | 1 |
| Aparicio, SA; Berg, T; Bilenky, M; Chang, H; Cheng, SW; Gascoyne, RD; Hirst, M; Humphries, RK; Lai, CK; Lai, D; Lee, S; Lim, E; Marra, MA; Morin, GB; Morin, RD; Mungall, AJ; Oellerich, T; Rosten, P; Salmi, A; Schoeler, N; Serve, H; Thoene, S; Umlandt, P; Wee, T; Yap, D; Yue, L | 1 |
| Du, M; Finnegan, EJ; Koltunow, AM; Luo, M; Zhang, R | 1 |
| Chadwick, BP; Darrow, EM; Das, S; Figueroa, DM; Moseley, SC; Seberg, AP; Sun, Z | 1 |
| Brasier, AR; Fang, H; Sowers, LC; Tang, H; Yin, E; Zhang, K | 1 |
| Kelleher, NL; Sweet, SM; Thomas, PM; Tipton, JD; Zheng, Y | 1 |
| Feng, D; Hu, Q; Li, H; Ma, H; Su, Y; Tao, H; Wang, X; Zhang, C | 1 |
| Chen, J; Guo, H; Li, Z; Liu, S; Nolan, T; Schnable, PS; Wang, X; Xie, Z; Ye, H; Yin, Y; Zhang, M | 1 |
| Li, Z; Shi, Z; Zhang, G | 1 |
| Barbash, O; Butte, AJ; Dhanak, D; Garcia, BA; Gozani, O; Huddleston, M; Jansen, PW; Khatri, P; Kruger, RG; Liu, S; Mazur, PK; Reynoird, N; Sage, J; Tummino, PJ; Van Aller, GS; Vermeulen, M; Wilkinson, AW | 1 |
| Börsch-Haubold, AG; Haubold, B; Konrad, K; Montero, I | 1 |
| Cao, HX; Messing, J; Schubert, I; Vu, GT; Wang, W | 1 |
| Van Rechem, C; Whetstine, JR | 1 |
| Clark, DJ; Cooper, GL; Funk, KE; Kuret, J; Liao, Z; Schafer, KN; Thomas, SN; Yang, AJ | 1 |
| Bach, I; Bossenz, M; Byron, M; Gallant, J; Jiao, B; Jones, SN; Lawrence, JB; Mager, J; Marcho, C; Shin, J; Wallingford, MC | 1 |
| Afif, H; Benderdour, M; El Mansouri, FE; Fahmi, H; Kapoor, M; Martel-Pelletier, J; Nebbaki, SS; Pelletier, JP | 1 |
| Gao, SB; Jin, GH; Li, KL; Lin, X; Pan, CB; Xu, B; Xue, LX; Zhao, Y; Zheng, QF; Zheng, QL | 1 |
| Diao, YF; Jin, DI; Kang, JW; Li, XX; Lin, T; Oqani, RK | 1 |
| Ayrapetov, MK; Gursoy-Yuzugullu, O; Price, BD; Xu, C; Xu, Y | 1 |
| Chen, Z; Li, Z; Lu, S; Niu, X; Shen, S; Tang, N; Xu, L; Xu, Y; Ye, X | 1 |
| He, Q; Li, H; Li, J; Li, Y; Liu, L | 1 |
| Cao, C; Guo, X; Lan, W; Liu, M; Rong, N; Song, Y; Xu, Y; Yang, H; Zhang, X; Zhang, Y | 1 |
| Jia, X; Li, Y; Liu, B; Ye, M; Zhang, X | 1 |
| Brown, PJ; Burgess-Brown, N; Eram, MS; Hajian, T; Szykowska, A; Vedadi, M; Yu, W | 1 |
| Carroll, J; Ding, S; Fearnley, IM; He, J; Rhein, VF; Walker, JE | 1 |
| Bedford, MT; Carr, SM; Fedorov, O; Johansson, C; Krojer, T; La Thangue, NB; Munro, S; Oppermann, U; Sagum, CA; Zalmas, LP | 1 |
| Köhler, C; Moreno-Romero, J; Risueño, MC; Rodríguez-Sanz, H; Solís, MT; Testillano, PS | 1 |
| Chen, J; Fu, Y; Li, C; Pang, B; Shen, K; Zhao, J | 1 |
| Baker, JC; Benayoun, BA; Brunet, A; Cherry, JM; Daugherty, AC; Devarajan, K; Gupta, R; Hitz, BC; Karra, K; Kundaje, AB; Mahmoudi, S; Mancini, E; Pollina, EA; Rando, TA; Snyder, MP; Ucar, D; Wong, ED | 1 |
| Cheng, X | 1 |
| Erce, MA; Hamey, JJ; Hart-Smith, G; Wilkins, MR; Zhang, L | 1 |
| Hiradate, Y; Inoue, H; Sato, E; Shirakata, Y; Tanemura, K | 1 |
| Chen, J; Chowdhury, F; Doğanay, S; Ha, T; Hong, Y; Huang, B; Jia, H; Jia, Q; Li, Y; Lin, LJ; Poh, YC; Seong, J; Singh, R; Tajik, A; Tan, Y; Wang, L; Wang, N; Wang, Y; Wei, F; Wu, DC; Yi, H; Zhang, S; Zhang, Y | 1 |
| Bandukwala, HS; Barboza, BA; Berg, LJ; Cruz-Guilloty, F; Engel, I; Kronenberg, M; Lee, Y; Lio, CW; Martinez, GJ; Pereira, RM; Rao, A; Tsagaratou, A | 1 |
| Hwang, JY; Kaneko, N; Noh, KM; Pontarelli, F; Zukin, RS | 1 |
| Ahier, A; Jarriault, S; Margueron, R; Morin, MC; Portoso, M; White, ER; Zuryn, S | 1 |
| Cai, C; Chai, R; He, Y; Li, H; Sun, S; Yu, H | 1 |
| Aifantis, I; Akira, S; Bakogianni, S; Becksfort, J; Ferrando, AA; Holmfeldt, L; Jaenisch, R; King, B; Kruidenier, L; Loizou, E; Mullenders, J; Mullighan, CG; Nedjic, J; Ntziachristos, P; Paietta, E; Prinjha, R; Rowe, JM; Satoh, T; Strikoudis, A; Tallman, MS; Tonon, G; Trimarchi, T; Tsirigos, A; Van Vlierberghe, P; Welstead, GG; Xu, L | 1 |
| Becker, M; Cauchy, P; Hornich, V; Lin, Q; Müller, AM; Obier, N; Zenke, M | 1 |
| Chen, Z; Grzybowski, AT; Ruthenburg, AJ | 1 |
| Eissenberg, JC; Florens, L; Gao, X; Herz, HM; Jackson, J; Morgan, M; Rickels, R; Shilatifard, A; Swanson, SK; Washburn, MP | 1 |
| Kornacki, JR; Mrksich, M; Stuparu, AD | 1 |
| Cheng, S; Du, JX; Fang, L; Li, J; Shi, G; Wong, J; Wu, M; Yu, F | 1 |
| Baker, J; Gupta, R; Ucar, D; Wills, A | 1 |
| Cui, WP; Guo, QY; Miao, LN; Sun, GD | 1 |
| Beck, AH; Collins, LC; Hazra, A; Healey, MA; Hu, R; Schnitt, SJ; Tamimi, RM | 1 |
| Akcali, KC; Ayaloglu-Butun, F; Demirel-Yilmaz, E; Han, S; Uludag, MO; Usanmaz, SE | 1 |
| Dejaegere, A; Grauffel, C; Stote, RH | 1 |
| Gao, N; Wu, J; Xi, Q; Ye, W; Zhang, B; Zhang, X | 1 |
| Cuddapah, S; Hattori, T; Jagannathan, L; Jose, CC; Koide, S; Lai, D; Mallela, RK; Schones, DE; Trac, C; Xu, B | 1 |
| Chen, Z; Cole, PA; Karukurichi, KR; Kavran, JM; Leahy, DJ; Wang, Y | 1 |
| Ahn, S; Ryu, HY | 1 |
| Feng, X; Garg, S; Liao, L; Liu, J; Mandel, G; McGann, JC; Oyer, JA; Yao, H; Yates, JR | 1 |
| Annan, R; Bai, Y; Creasy, CL; Dhanak, D; Dul, E; Graves, AP; Groy, A; Halsey, WS; Huddleston, M; Hughes, AM; Jiang, Y; Knight, SD; Kruger, RG; McCabe, MT; Ott, HM; Pappalardi, MB; Schwartz, B; Tummino, PJ; Verma, SK | 1 |
| Huang, P; Jin, J; Pan, Y; Sang, J; Shao, G; Wang, J; Zhang, L | 1 |
| Cui, W; Kong, L; Li, X; Luo, M; Miao, L; Tan, Y; Wu, H; Xu, F; Zhou, S | 1 |
| Bustos, R; Jarillo, JA; López-González, L; Martínez-Zapater, JM; Mouriz, A; Narro-Diego, L; Piñeiro, M | 1 |
| Henry, C; Jeltsch, A; Jurkowska, RZ; Kudithipudi, S; Kungulovski, G; Kycia, I; Labhart, P; Reinhardt, R; Tamas, R | 1 |
| Anlembom, TE; Ginsburg, DS; Hinnebusch, AG; Li, B; Patel, SR; Wang, J | 1 |
| Deng, J; Fang, LC; Huang, H; Li, Y; Yang, ZL; Yao, J; Zheng, J | 1 |
| Ferguson, DJ; Girosky, KE; Kountz, DJ; Krzycki, JA; Ticak, T | 1 |
| Garcia, BA; Karch, KR; Zee, BM | 1 |
| Bessaire, T; Delatour, T; Stadler, RH; Tarres, A | 1 |
| Hu, Z; Liu, Y; Qiu, J; Xiong, Z; Zheng, J; Zhu, Z | 1 |
| Fearon, ER; Gibbons, GS; Nikolovska-Coleska, Z; Owens, SR | 1 |
| Bertke, MM; Huber, PW; Malik, MQ | 1 |
| Colón-Bolea, P; Crespo, P | 1 |
| Xu, RS; Xu, X; Ye, L; Zhang, BP; Zheng, LW; Zhou, XD | 1 |
| Busturia, A; Fereres, S; Mohd-Sarip, A; Simón, R; Verrijzer, CP | 1 |
| Dahl, HA; Falnes, PØ; Ho, AY; Małecki, J; Moen, A | 1 |
| Aharoni, S; Altarescu, G; Avitzour, M; Eiges, R; Eldar-Geva, T; Epsztejn-Litman, S; Levy-Lahad, E; Mor-Shaked, H; Renbaum, P; Schonberger, O; Yanovsky-Dagan, S | 1 |
| Bradner, JE; Brown, VE; Chen, MW; Choi, YJ; Fritz, CC; Guenther, MG; Olson, ER; Orlando, DA; Solanki, S | 1 |
| Bain, JV; Beaver, JE; James, LI; Peacor, BC; Waters, ML | 1 |
| Jeltsch, A; Kudithipudi, S; Kusevic, D; Schuhmacher, MK; Weirich, S | 1 |
| Heras, S; Leemans, B; Smits, K; Van Soom, A | 1 |
| Ciccaglione, K; Law, MJ | 1 |
| Chen, X; Göndör, A; Ohlsson, R; Shi, C; Tark-Dame, M; Yammine, S | 1 |
| Hamamoto, R; Jenuwein, T; Nakakido, M; Nakamura, Y; Piao, L; Sone, K; Ueda, K | 1 |
| Devulapally, R; Foygel, K; Paulmurugan, R; Sekar, TV | 1 |
| Jeltsch, A; Kudithipudi, S; Kusevic, D; Weirich, S | 1 |
| di Luccio, E; Mevius, D; Morishita, M | 1 |
| Cheng, Z; He, T; Liu, P; Sun, M; Tan, M; Wan, X; Wu, Z; Zhao, Y | 1 |
| Foygel, K; Gelovani, JG; Paulmurugan, R; Sekar, TV | 1 |
| Liu, Q; Liu, Y; Lu, X; Luo, F; Qin, Y; Shi, L; Wang, B; Xiang, Q; Xu, W; Xu, Y | 1 |
| Guppy, BJ; McManus, KJ | 1 |
| Chen, E; Gu, SG; Ni, JZ | 1 |
| Beland, FA; Burnett, SD; de Conti, A; Doerge, DR; Fuscoe, JC; Han, T; Kobets, T; Pogribny, IP; Tryndyak, V | 1 |
| Bakiri, L; Ezhkova, E; García, F; Guinea-Viniegra, J; Muñoz, J; Wagner, EF; Wurm, S; Zhang, J | 1 |
| Cohen, E; Harr, JC; Luperchio, TR; Reddy, KL; Wheelan, SJ; Wong, X | 1 |
| Lai, EC; Lim, V; Schlissel, MS; Timblin, GA; Vettermann, C | 1 |
| Cosgrove, MS; Monteith, KE; Shinsky, SA; Viggiano, S | 1 |
| Aryee, MJ; Benes, CH; Black, JC; Boukhali, M; Gräslund, S; Haas, W; Van Rechem, C; Whetstine, JR | 1 |
| Chisholm, NC; Dindot, S; Henderson, ML; Miranda, RC; Park, MJ; Selvamani, A; Sohrabji, F | 1 |
| Adams, IR; Li, P; Ma, X; Yuan, P | 1 |
| Asashima, M; Matsukawa, S; Michiue, T; Miwata, K | 1 |
| McGrath, J; Trojer, P | 1 |
| Becker, PB; Feller, C; Forné, I; Imhof, A | 1 |
| Chen, X; Liu, G; Liu, H; Xiong, S; Xu, G; Zheng, B | 1 |
| Ding, S; Fearnley, IM; Jiang, H; Palmer, DN; Walker, JE; Walpole, TB | 1 |
| Anjanappa, M; Appaiah, HN; Badve, S; Bhat-Nakshatri, P; Crooks, PA; Gilley, D; Mathews, W; Nakshatri, H; Sweeney, C; Tanaka, H | 1 |
| Hamamoto, R; Nakamura, Y; Saloura, V | 1 |
| Ancelin, K; Burlina, F; Caron, M; da Rocha, ST; Gamblin, SJ; Heard, E; Justin, N; Loew, D; Lombard, B; Margueron, R; Michaud, A; Offer, J; Portoso, M; Sanulli, S; Servant, N; Teissandier, A; Wassef, M | 1 |
| Anan, K; Hino, S; Nagaoka, K; Nakao, M; Sakamoto, A; Sasaki, Y; Takase, R; Umehara, T; Yokoyama, S | 1 |
| Abraham, SJ; Cheng, RC; Chew, TA; Gong, S; Khantwal, CM; Liu, CW; Maduke, M; Nakamoto, RK | 1 |
| Jiao, Y; Liu, Z; Zhang, Y; Zhu, YX | 1 |
| Jakoncic, J; Li, J; Morohashi, K; Plotnikov, AN; Ren, C; Rodriguez, Y; Smith, SG; Stojanoff, V; Walsh, M; Zeng, L; Zhou, MM | 1 |
| Jeon, NL; Kim, BS; Kim, H; Kim, J; Noh, M; Yoo, J | 1 |
| Costa, M; Liu, Y; Tu, W; Xia, Y; Xiao, C; Xie, C; Zhou, X | 1 |
| Clouaire, T; Legube, G | 1 |
| Guo, X; Jiang, L; Liu, K; Liu, X; Lv, J; Peng, C; Ren, Y; Terzaghi, W; Wan, J; Wang, C; Wang, Y; Wu, T; Zhao, S; Zheng, M | 1 |
| Arnott, D; Cheung, T; Classon, M; Guler, GD; Izrael-Tomasevic, A; Liang, J; Maile, TM; Masselot, A; Tindell, C; Trojer, P; Zhao, F | 1 |
| Ferrao, R; Garcia, BA; Hempel, K; Laurent, B; Liu, S; Murn, J; Ruitu, L; Shi, Y; Steen, H; Wu, F; Wu, H; Xiang, Y | 1 |
| Bosselut, R; Dobenecker, MW; Fang, TC; Kim, JK; Marcello, J; Prinjha, R; Tarakhovsky, A | 1 |
| Cao, X; Ding, Y; Guo, Z; Li, X; Liu, Y; Zhang, Q; Zhao, D; Zhao, K | 1 |
| de Smith, A; Fomin, ME; Heath, S; Houseman, EA; Lee, ST; Martín-Subero, JI; Metayer, C; Muench, MO; Roy, R; Wiemels, JL; Wiencke, J; Wrensch, M; Xiao, J; Zhou, M | 1 |
| Gao, J; Guo, S; Guo, Y; Li, C; Zhang, M | 1 |
| Ichikawa, K; Morishita, S | 1 |
| Antonini, E; Cittaro, D; Frenquelli, M; Gaviraghi, M; Lemaitre, JM; Lupi, A; Rondinelli, B; Schwerer, H; Segalla, S; Tonon, G | 1 |
| Andrianopoulos, A; Berger, H; Gacek-Matthews, A; Gruber, C; Marcos, AT; Noble, LM; Strauss, J; Sulyok, M | 1 |
| Hunter, CS; Maganti, AV; Maier, B; Mirmira, RG; Mosley, AL; Özcan, S; Pachaiyappan, B; Sampley, ML; Stein, R; Tersey, SA; Woster, PM | 1 |
| Ghanbarian, AT; Hurst, LD | 1 |
| Abeygunawardena, D; Erce, MA; Hart-Smith, G; Wilkins, MR; Winter, DL | 1 |
| Eulgem, T; Tsuchiya, T | 1 |
| Bian, C; Chen, Q; Yu, X | 1 |
| Li, Y; Lu, Q; Luo, Y; Shi, Y; Wang, Q; Xiao, R; Xiao, Y; Zhao, M | 1 |
| Azpiazu, N; Cantero, W; Zaballos, MA | 1 |
| Colón-Caraballo, M; Flores, I; Monteiro, JB | 1 |
| Fujinaka, H; Garessus, S; Hasegawa, M; Horlacher, O; Kinoshita, N; Lisacek, F; Magdeldin, S; Muller, M; Nikitin, F; Xu, B; Yamamoto, T; Yaoita, E; Yoshida, Y; Zhang, Y | 1 |
| Duboule, D; Fabre, PJ; Leleu, M; Noordermeer, D; Vieux-Rochas, M | 1 |
| Dunne, K; Flashman, E; Hancock, RL; Kawamura, A; Walport, LJ | 1 |
| Allshire, RC; Audergon, PN; Catania, S; Kagansky, A; Pidoux, AL; Shukla, M; Tong, P | 1 |
| Helfand, SL; Lee, SS; Ni, Z; Pu, M; Wang, M; Wang, X; Wood, JG; Yu, H | 1 |
| Barde, I; Cassano, M; Jang, SM; Kapopoulou, A; Rauwel, B; Trono, D | 1 |
| Dong, A; Huang, Y; Jin, J; Liu, B; Liu, Y; Shi, J; Yu, Y | 1 |
| Anderson, KE; Baalbaki, M; Divecha, N; Fischle, W; Gelato, KA; Giardoglou, P; Haramis, AP; Hart, D; Hawkins, P; Jones, DR; Lauberth, SM; Rahnamoun, H; Shah, Z; Sommer, L; Stijf-Bultsma, Y; Tauber, M; Toma, C; van Pelt, J | 1 |
| Cao, H; Chen, Z; Leng, X; Liu, X; Ouyang, G; Xiao, W; Xu, C | 1 |
| Deng, Z; Dohmae, N; Hamamoto, R; Nakakido, M; Nakamura, Y; Suzuki, T | 1 |
| Aoshima, K; Inoue, E; Okada, Y; Sawa, H | 1 |
| Halsall, JA; Terrenoire, E; Turner, BM | 1 |
| Goda, T; Mochizuki, K; Morioka, K; Muramatsu, T; Suzuki, T | 1 |
| Berger, DK; Groover, A; Hussey, SG; Mizrachi, E; Myburg, AA | 1 |
| Gribnau, J; Grootegoed, JA; Loda, A; Loos, F; van Wijk, L | 1 |
| Culmes, M; Eckstein, HH; Gebhard, H; Greißel, A; Napieralski, R; Pelisek, J; Schmitt, M; Wagner, E; Zernecke, A; Zimmermann, A | 1 |
| Evans-Molina, C; Fujimaki, K; Fujitani, Y; Iida, H; Mirmira, RG; Morris, DL; Oda, H; Ogihara, T; Watada, H | 1 |
| Fujiyoshi, Y; Hojo, H; Kawakami, T; Mishima, Y; Suetake, I; Tajima, S; Yoshikawa, R | 1 |
| Cetinkaya, M; Dalay, N; Gezer, U; Özgür, E | 1 |
| Brand, LH; Gaudin, V; Harter, K; Hecker, A; Kilian, J; Peter, S; Simoncello, N; Wanke, D | 1 |
| Castle, EP; Champion, MD; Dykema, K; Ho, TH; Hoang, A; Hung, MC; Jonasch, E; Joseph, RW; Monzon, FA; Nunez-Nateras, R; Park, IY; Parker, AS; Qiao, W; Tamboli, P; Tannir, NM; Teh, BT; Tong, P; Walker, CL; Wang, J; Yan, H; Zhao, H | 1 |
| Novaira, HJ; Radovick, S; Sonko, ML | 1 |
| Carrillo, JA; Song, J; Tian, F; Updike, SM; Zan, L; Zhan, F; Zhao, C; Zhao, K | 1 |
| Casas-Mollano, JA; Cerutti, H; Riethoven, JJ; Wang, Z; Xu, J; Zhang, C | 1 |
| Collins, PL; Egawa, T; Kyle, KE; Oltz, EM; Shinkai, Y | 1 |
| Aggarwal, V; Anantharaman, A; Chakraborty, A; Ghosh, AK; Giri, S; Ha, T; Khan, A; Prasanth, KV; Prasanth, SG; Sathyan, KM; Wang, Y | 1 |
| Koh, W; Lee, S; Park, B | 1 |
| Davydova, E; Falnes, PØ; Jakobsson, ME; Małecki, J; Moen, A | 1 |
| Chua, NH; Deng, S; Kim, SH; Liu, J; Shi, S; Xu, J | 1 |
| Ghosal, A; Kapadia, R; Nabokina, SM; Said, HM; Subramanian, VS | 1 |
| Cao, H; Chen, F; Ding, M; Dong, F; Doughty, J; Li, X; Li, Y; Liu, L; Liu, YX; Sun, Y; Wang, Z | 1 |
| Bhar, K; Chakrabarti, R; Das, C; Ghosh, A; Sanyal, S; Siddhanta, A | 1 |
| Larrick, JW; Mendelsohn, AR | 1 |
| Cleary, ML; Duque-Afonso, J; Goode, DL; Iwasaki, M; Kuo, HP; Schneidawind, D; Wei, MC; Weng, Z; Wong, SH; Zhu, L | 1 |
| Hou, FF; Lei, W; Li, S; Liu, Z; Long, Y; Nie, J; Zhu, F | 1 |
| Lee, JT; Sunwoo, H; Wu, JY | 1 |
| Kramer, JM | 1 |
| Huang, Y; Shi, X; Zhang, X | 1 |
| David, Y; Holt, MT; Jeon, J; Kim, J; Muir, TW; Pollock, S; Roeder, RG; Tang, Z | 1 |
| Chen, J; Cheong, A; Ho, SM; Hu, WY; Lam, HM; Leung, YK; Medvedovic, M; Prins, GS; Shi, GB; Zhang, X; Zhu, X | 1 |
| Bando, T; Hamada, Y; Ishimaru, Y; Mito, T; Nakamura, T; Noji, S; Ohuchi, H; Tomioka, K | 1 |
| Cao, JZ; Gu, H; Ju, Z | 1 |
| Canterbury, J; Compton, PD; Fellers, RT; Fornelli, L; Kelleher, NL; Licht, JD; Mullen, C; Senko, MW; Sharma, S; Thomas, PM; Zabrouskov, V; Zheng, Y | 1 |
| Boyd, NH; Greer, SF; Morgan, JE | 1 |
| Chen, X; Liu, X; Zhao, Y; Zhou, DX | 1 |
| Fu, H; Shen, J; Su, J; Wu, D; Xu, M; Zhang, F; Zhou, H | 1 |
| Boenisch, U; Bovio, PP; Grüning, BA; Heidrich, S; Hellbach, N; Nestel, S; Roidl, D; Villarreal, A; Vogel, T | 1 |
| Chan, FL; Collas, P; M Chang, FT; Mann, JR; Mayne, L; Pickett, HA; R McGhie, JD; Tang, MC; Udugama, M; Wong, LH | 1 |
| Alam, H; Gu, B; Lee, MG | 1 |
| Artinian, L; Li, F; Liang, H; Rehder, V; Shi, H; Wu, R; Xue, B; Yu, L; Zha, L | 1 |
| Gan, ES; Ito, T; Xu, Y | 1 |
| Barsotti, AM; Rollins, RA; Ryskin, M | 1 |
| Carlton, P; Hojo, H; Jayasinghe, CD; Kawakami, T; Kimura, H; Lu, K; Mishima, Y; Otani, J; Shirakawa, M; Suetake, I; Tajima, S | 1 |
| Lu, T; Stark, GR | 1 |
| Liu, XJ; Wang, DY; Zhu, HG; Zhu, R; Zou, LP | 1 |
| Davie, JR; Delcuve, GP; Xu, W | 1 |
| Capanni, C; Cavallo, C; Columbaro, M; D'Apice, MR; Lattanzi, G; Murdocca, M; Pellegrini, C; Squarzoni, S | 1 |
| Honda, T; Kawamura, M; Sugimura, H; Susumu, H; Tanno, Y; Watanabe, Y | 1 |
| Feng, X; Guang, S; Huang, H; Liu, D; Mao, H; Weng, C; Yang, X; Zhu, C; Zong, D | 1 |
| Kitagawa, K; Kitagawa, M; Leeb, M; Matsumoto, M; Niida, H; Ohhata, T; Sakai, S; Shibata, S; Wutz, A | 1 |
| N Power, A; Pinkin, NK; Waters, ML | 1 |
| Jin, SG; Pfeifer, GP; Wu, X; Xiong, W; Yang, L | 1 |
| González, AJ; Leslie, CS; Setty, M | 1 |
| Cieniewicz, AM; Ringel, AE; Taverna, SD; Wolberger, C | 1 |
| Carr, SM; Chan, C; La Thangue, NB; Poppy Roworth, A | 1 |
| Chen, L; Xiao, Z; Zhang, W; Zhou, Q | 1 |
| Almouzni, G; Alvarez, F; Díaz-Celis, C; Forné, I; Gurard-Levin, ZA; Imhof, A; Li, J; Loyola, A; Rivera, C; Saavedra, F; Ugalde, V | 1 |
| Arnold, DR; Faccio, BM; Lopes, FL; Maldonado, MB; Penteado, JC | 1 |
| An, J; Hu, Y; Qin, J; Wan, Y; Zeng, W; Zhang, C; Zhang, Y | 1 |
| Anttila, V; Bulik-Sullivan, B; Daly, MJ; Day, FR; Farh, K; Finucane, HK; Gusev, A; Lindstrom, S; Loh, PR; Neale, BM; Okada, Y; Patterson, N; Perry, JR; Price, AL; Purcell, S; Raychaudhuri, S; Reshef, Y; Ripke, S; Stahl, E; Trynka, G; Xu, H; Zang, C | 1 |
| Belle, R; Mecinović, J; Meulenbroeks, E; Pieters, BJ | 1 |
| Murakami, A; Watanabe, S | 1 |
| Hromas, R; Kim, HS; Kim, SK; Lee, SH | 1 |
| Armstrong, SA; Chen, S; Deshpande, AJ; Garcia, BA; Gozani, O; Krajewski, K; Patel, DJ; Sidoli, S; Strahl, BD; Wilkinson, AW; Yang, Z | 1 |
| Arihiro, K; Doi, S; Doi, T; Irifuku, T; Kohno, N; Masaki, T; Nakashima, A; Sasaki, K; Ueno, T; Yamada, K | 1 |
| Ariyan, CE; Berger, MF; Borsu, L; Busam, KJ; Button, J; Cao, Z; Chen, Y; Chi, P; Fagin, JA; Gao, D; Hollmann, TJ; Hu, W; Ladanyi, M; Lailler, N; Landa, I; Lee, W; Merghoub, T; Murali, R; Murphy, DA; Obenauf, AC; Postow, MA; Ran, L; Sboner, A; Schwartz, GK; Scott, SN; Shah, RH; Shukla, S; Wang, L; Wiesner, T; Wong, EW; Zhang, QF; Zheng, D | 1 |
| Davidson, B; Falnes, PØ; Jakobsson, ME; Moen, A | 1 |
| Abbas, A; Al-Mulla, F; Georgel, PT; Hall, JA; Ho, E; Hsu, A; Patterson, WL | 1 |
| Christensen, J; Friis, C; Helin, K; Jensen, ON; Mariani, L; Salcini, AE; Sidoli, S; Vandamme, J | 1 |
| Angelini, C; Anvar, Z; Baglivo, I; Cammisa, M; Cerrato, F; De Feis, I; Feil, R; Girardot, M; Grimaldi, G; Kukreja, H; Lad, S; Pedone, PV; Riccio, A; Riso, V; Sparago, A | 1 |
| Chen, H; Jiang, C; Li, X; Li, Y; Pan, T; Wang, Z; Xu, J; Zhang, J; Zhao, Z | 1 |
| Chen, L; Deng, XW; Fan, L; He, G; Huang, H; Ren, D; Su, Y; Wang, X; Yang, M; Zhu, D; Zhu, P | 1 |
| Li, Z; Sun, HG; Sun, Y; Wang, FQ; Wang, XM; Xie, CR; Yin, ZY; Zhang, S; Zhao, WX | 1 |
| Aileni, VK; Egge-Jacobsen, W; Falnes, PØ; Fusser, M; Kernstock, S; Klungland, A | 1 |
| Hamey, JJ; Hart-Smith, G; Overall, CM; Wilkins, MR; Winter, DL; Yagoub, D | 1 |
| Hatanaka, Y; Inoue, K; Kamimura, S; Kodama, EN; Ogonuki, N; Ogura, A; Ohkawa, Y; Oikawa, M; Tsukada, Y | 1 |
| Choi, SI; Kim, EK; Kim, KS; Lee, GH; Maeng, YS | 1 |
| Coleman, PD; Delvaux, E; Grover, A; Mastroeni, D; Nolz, J; Oddo, S; Tan, Y | 1 |
| Harikumar, A; Meshorer, E | 1 |
| Brinkø, A; Hopkinson, RJ; Langley, GW; Münzel, M; Schofield, CJ; Walport, LJ | 1 |
| Best, G; Birk, UJ; Borsos, M; Cremer, C; Fournier, D; Ketting, RF; Parekh, SH; Prakash, K; Redl, S; Tachibana-Konwalski, K; Tiwari, VK | 1 |
| Andrau, JC; Descostes, N; Eick, D; Flatley, A; Forné, I; Gut, I; Gut, M; Heidemann, M; Hintermair, C; Imhof, A; Kremmer, E; Maqbool, MA; Schüller, R; Voss, K | 1 |
| Battle, SL; Bielas, JH; Blau, CA; Detraux, D; Devi, A; Ericson, NG; Ferreccio, A; Fiehn, O; Fischer, KA; Gu, H; Hawkins, RD; Hesson, J; Hockenbery, D; Margaretha, L; Margineantu, D; Margolin, AA; Mathieu, J; Moon, RT; Raftery, D; Robitaille, AM; Ruohola-Baker, H; Showalter, M; Sperber, H; Valensisi, C; Wang, Y; Ware, CB; Xu, Z | 1 |
| Alessandri, I; Bergese, P; Biavardi, E; Dalcanale, E; Gianoncelli, A | 1 |
| Beuming, T; Dong, A; Huang, J; Kamps, JJ; Li, H; Matthias Bickelhaupt, F; Mecinović, J; Min, J; Pieters, BJ; Poater, J; Sherman, W; Xu, C | 1 |
| An, W; Kim, JM; Kim, K; Liang, G; Lu, W; Punj, V; Ulmer, TS | 1 |
| Gozani, O; van Nuland, R | 1 |
| Choi, JK; Jung, I; Kim, D; Lee, HS; Seo, J; Stanton, LW | 1 |
| D'Angiolella, V; Dianov, GL; Drobnitzky, N; Humphrey, TC; Jiang, Y; La Thangue, NB; Macaulay, VM; Markkanen, E; Mavrommati, I; Orlando, G; Pai, CC; Pfister, SX; Ryan, AJ; Sarkar, S; Verrill, C; Woodcock, M; Ying, S; Zalmas, LP | 1 |
| Blee, TK; Brook, M; Gray, NK | 1 |
| Avaritt, NL; Byrum, SD; Davis, L; Mackintosh, SG; Mahmoud, F; Orr, LM; Reynolds, M; Sengupta, D; Shalin, SC; Shields, B; Tackett, AJ | 1 |
| Chen, J; Huang, K; Jiang, C; Li, H; Li, J; Lin, J; Liu, H; Pan, G; Pei, D; Shi, G; Shi, J; Wang, Z; Yao, H; Yao, M; Zhang, B; Zhang, X | 1 |
| Chao, SB; Huang, XJ; Lin, F; Liu, HL; Ma, XS; Meng, TG; Qin, L; Schatten, H; Sun, QY; Wang, XG; Zhu, CC | 1 |
| Hur, W; Hwang, JT; Jeong, JC; Kang, MR; Kim, EJ; Kwon, YS; Park, JH; Park, UH; Song, BJ; Um, SJ; Yoon, SK | 1 |
| Hou, Y; Huang, S; Li, L; Liu, L; Rao, Q; Sun, L; Wang, L; Zhang, J | 1 |
| Fan, L; Shen, X; Yu, F; Yu, Z | 1 |
| De Domenico, E; Di Giacomo, D; Geremia, R; Grimaldi, P; Sette, C | 1 |
| Albertí, S; Conn, GL; Dammer, EB; Duong, DM; Goldberg, JB; Kuiper, EG; Meisner, J; Owings, JP; Prezioso, SM; Seyfried, NT; Varga, JJ; Zelinskaya, N | 1 |
| Bai, DL; Bailey, AO; Black, BE; Foltz, DR; Hunt, DF; Lehman, SM; Panchenko, T; Shabanowitz, J | 1 |
| Brookes, E; Chotalia, M; Dias, JD; Ferrai, C; Kimura, H; Kukalev, A; Pombo, A; Rito, T; Torlai Triglia, E | 1 |
| Fan, Z; Fang, M; Hao, C; Li, J; Li, M; Tian, W; Wu, X; Xu, H; Xu, Y; Zhang, L; Zhou, B | 1 |
| Bluhm, A; Butter, F; Casas-Vila, N; Scheibe, M | 1 |
| Hu, T; Poethig, RS; Smith, MR; Xu, M | 1 |
| Hou, L; Li, M; Li, Q; Yu, Y; Zhang, D | 1 |
| Fan, X; Guo, F; Guo, H; Hu, B; Li, R; Qiao, J; Tang, F; Wang, W; Wang, X; Wang, Y; Wei, Y; Wen, L; Yan, L; Yong, J; Zhao, Y; Zhi, X | 1 |
| Lakowski, TM; Lillico, R; Sobral, MG; Stesco, N | 1 |
| Andrews, FH; Gatchalian, J; Krajewski, K; Kutateladze, TG; Strahl, BD | 1 |
| Cui, X; Li, F; Shi, H; Wu, R; Xue, B; Yu, L; Zha, L | 1 |
| Campbell, RM; Cao, XJ; Chen, LH; Garcia, BA; Han, B; Horvath, A; Nguyen, H; Olsen, JB; Richardson, TI | 1 |
| Agarwal, P; Alzrigat, M; Brown, PJ; Enroth, S; Jernberg-Wiklund, H; Jin, J; Kalushkova, A; Ma, A; Nilsson, K; Öberg, F; Österborg, A; Párraga, AA; Singh, U; Ungerstedt, J | 1 |
| Cang, S; Chiao, JW; Liu, D; Ma, Y; Xu, X | 1 |
| Beaver, JE; Waters, ML | 1 |
| Hou, W; Huddleston, MJ; Johnson, NW; Matico, RE; McDevitt, PJ; Meek, TD; Poulin, MB; Schneck, JL; Schramm, VL; Thrall, SH | 1 |
| Chan, AW; Chan, MT; Cheng, AS; Kang, W; Lai, PB; Lau, SS; Lee, SD; Lee, TL; Lee, YY; Li, MS; Li, X; Lo, KW; To, KF; Tong, JH; Tsang, DP; Wang, H; Wong, N; Wu, F; Wu, WK; Xiong, L; Xu, G; Yang, W; Yang, Y; Yip, KY; Yu, DY; Yu, J; Yu, Z | 1 |
| Agarwal, S; Badeaux, AI; Brookes, E; Chen, C; Egan, B; Gu, L; Ito, H; Iwase, S; Kasza, T; Kwan, KY; Lin, G; Sartor, MA; Shi, Y; Thompson, A; Tomassy, GS; Vallianatos, CN; Xu, J | 1 |
| Lussi, YC; Mariani, L; Riveiro, A; Salcini, AE; Vandamme, J | 1 |
| Chen, A; Feldman, M; Levy, D; Vershinin, Z | 1 |
| Davie, JR; Gonzalez, C; Hamedani, MK; Khan, DH; Leygue, E; Tailor, N | 1 |
| Ghosh, S; Leow, MK; Lesmana, R; Liao, XH; Ohba, K; Refetoff, S; Singh, BK; Sinha, RA; Sng, JC; Yen, PM | 1 |
| Bendrin, K; Fischer, T; Ohle, C; Schermann, G; Tucker, JF; Zhang, K; Zhang, W | 1 |
| Baranauskienė, L; Burgahn, T; Fedorov, O; Greschik, H; Jin, J; Jung, M; Matulis, D; McMillan, J; Oppermann, U; Schmidtkunz, K; Schott, AK; Schüle, R; Wagner, T; Xiong, Y | 1 |
| Ding, JC; Gao, WW; Huang, MF; Liu, W; Peng, BL; Shen, HF; Shi, TT; Shu, XY; Wang, FF; Wu, XN; Xiao, RQ; Xu, HT; Yi, J; Zhang, WJ | 1 |
| Ewert, S; Haider, S; Jovanovic, S; Mujtaba, S; Nwasike, C | 1 |
| Ang, SY; Bruneau, BG; Ge, K; Huang, Y; Lee, JE; Spencer, CI; Uebersohn, A | 1 |
| Hashiguchi, N; Hiragami-Hamada, K; Kawaguchi, A; Kidera, A; Moritsugu, K; Nakayama, J; Nishimura, Y; Oda, T; Omori, S; Sato, M; Shimojo, H | 1 |
| Chua, NH; Deng, S; Liu, J; Sun, HX; Wang, H; Wu, HW; Ye, J | 1 |
| Aitken, KJ; Bägli, DJ; Delgado-Olguin, P; Ibrahim, F; Jiang, JX; Penna, F; Rosenblum, N; Samiei, AN; Sidler, M; Ting, K; Tolg, C | 1 |
| Chen, F; Dong, S; Feng, Z; Liu, W; Mo, Q; Redell, M; Song, Y; Wei, L; Wu, F; Yao, Y; Zhou, C | 1 |
| Bhatti, B; Idris, MM; Kumar, A; Mandal, KK; Meena Lakshmi, MG; Meghah, V; Narasimha Murthy, ChL; Poruri, A; Purushothaman, S; Sarath Babu, N; Saxena, S | 1 |
| Garnett, GA; Hof, F; Li, J; Shaurya, A; Starke, MJ | 1 |
| Baek, SH; Kim, KI | 1 |
| Chen, H; Fu, L; Han, H; Han, Z; Li, L; Lv, X; Pan, C; Wei, G; Wu, M; Xia, Y; Yang, B; Yang, X; Zhang, L; Zhang, S; Zhao, Y; Zhou, Z | 1 |
| Benvegnù, S; Carretero, J; Dotti, CG; Martin, MG; Palomer, E | 1 |
| Busslinger, M; Ebert, A; Ellwart, J; Hinterberger, M; Kazerani, M; Klein, L; Nuber, A; Pasquarella, A; Pereira de Almeida, G; Schotta, G | 1 |
| Hirano, K; Namihira, M | 1 |
| Couture, JF; Figeys, D; Lanouette, S; Mayne, J; Mierzwa, A; Ning, Z; Star, AT | 1 |
| Gu, T; Han, Y; Huang, R; Li, Y; McAvoy, RJ | 1 |
| Cao, X; Ding, Y; Li, N; Li, X; Li, Z; Liu, Y; Shen, Q; Wang, C; Zhang, Q; Zhao, D; Zhao, K | 1 |
| Ait-Si-Ali, S; Battisti, V; Boyarchuk, E; Fritsch, L; Joliot, V; Pontis, J; Robin, P | 1 |
| Betanzos, A; Borbolla-Vázquez, J; Chávez, B; Javier-Reyna, R; Martínez-Higuera, A; Medina-Gómez, C; Orozco, E; Rodríguez, MA | 1 |
| Fukuda, M; Harada, A; Hayashi-Takanaka, Y; Ichimaru, N; Ikura, T; Isaka, Y; Kaimori, JY; Kimura, H; Maehara, K; Matsuda, R; Nagao, K; Nozaki, N; Obuse, C; Ohkawa, Y; Takahara, S; Takao, T; Umehara, T; Yamamoto, S; Yokoyama, S | 1 |
| Feng, X; Juan, AH; Ko, KD; Sartorelli, V; Wang, HA; Zare, H | 1 |
| Chen, H; Xiao, D; Zheng, X; Zheng, Y | 1 |
| Ebbers, L; Nothwang, HG; Runge, K | 1 |
| Baubec, T; Chen, C; Chernev, A; De La Rosa-Velázquez, IA; Fischle, W; Hiragami-Hamada, K; Jenuwein, T; Kost, N; Kreuz, S; Lorincz, M; Neumann, H; Nikolov, M; Pohl, W; Schwarzer, D; Soeroes, S; Urlaub, H; Walla, PJ; Wilkins, B; Zenn, HM; Zimmermann, B | 1 |
| Jeltsch, A; Kudithipudi, S; Weirich, S | 1 |
| Aharoni, A; Cohen, DO; Duchin, S; Feldman, M; Levy, D; Zarivach, R | 1 |
| Allis, CD; Elemento, O; Falciatori, I; Giannopoulou, EG; Liu, Y; Rafii, S; Seandel, M; Wen, D | 1 |
| Chen, S; De Marco, V; Gamblin, SJ; Haire, LF; Justin, N; Martin, SR; Reinberg, D; Tarricone, C; Underwood, E; Walker, PA; Wilson, JR; Zhang, Y | 1 |
| Choy, E; Cote, GM; Duan, Z; Gao, Y; Hornicek, FJ; Mankin, HJ; Shen, JK | 1 |
| Cai, Y; Lei, PJ; Li, CY; Li, L; Su, SK; Wang, X; Wang, Z; Wu, M; Zhao, QY | 1 |
| He, Z; Li, H; Xiong, X; Zhang, X; Zhao, D | 1 |
| Armstrong, RL; Duronio, RJ; Li, Y; MacAlpine, DM | 1 |
| Coupland, G; Hyun, Y; Martinez-Gallegos, R; Porri, A; Richter, R; Vincent, C | 1 |
| Bungert, J; Deng, C; Gallagher, PG; Huang, S; Li, G; Li, Y; Ma, G; Qiu, Y; Schulz, VP; Shen, Y; Stees, J; Steiner, LA; Tusi, BK; Zhao, K; Zhou, L | 1 |
| Buechele, C; Cleary, ML; Duque-Afonso, J; Gozani, O; Hansen, L; Huang, M; Ikenouye, L; Klein, BJ; Kutateladze, TG; Li, Q; Majeti, R; Martin, GM; Onishi, M; Schneidawind, D; Shen, J; Wong, SH; Zhu, F; Zhu, L | 1 |
| Luo, D; Luo, K; Wen, H | 1 |
| Cakouros, D; Davis, MJ; Gronthos, S; Hemming, S; Vandyke, K; Zannettino, AC | 1 |
| Bai, X; Chen, P; Fan, E; Guo, Z; He, X; Jin, J; Lu, C; Tian, S; Zhai, G; Zhang, K; Zhang, Y; Zheng, S | 1 |
| Allis, CD; Andrulis, IL; Bechet, D; Chi, P; De Jay, N; Dickson, BC; Fahiminiyah, S; Garcia, BA; Grynspan, D; Hameed, M; Hoelper, D; Jabado, N; Jain, SU; Jani, KS; Lewis, PW; Lu, C; Lundgren, SM; Majewski, J; Molden, RC; Muir, TW; Murphy, D; Nadaf, J; Papillon-Cavanagh, S; Pawel, BR; Ran, L; Sawyer, SL; Thompson, CB; Turcotte, RE; Venneti, S; Wunder, JS | 1 |
| Decker, EL; Hasebe, M; Ishikawa, T; Katz, A; Lang, D; Mosquna, A; Nishiyama, T; Ohad, N; Pereman, I; Reski, R; Tamada, Y; Wiedemann, G | 1 |
| Bharathy, N; Manikandan, J; Ow, JR; Rao, VK; Shankar, SR; Taneja, R; Wang, Y | 1 |
| Bradley, EW; Bridge, JA; Chen, J; Chen, Y; Fang, D; Gan, H; Han, J; Ho, TH; Jin, L; Lee, JH; Oliveira, AM; Ordog, T; Riester, SM; Rubin, BP; Thibodeau, SN; van Wijnen, AJ; Wang, J; Wang, Z; Westendorf, JJ; Xu, RM; Yang, N; Zhang, H; Zhang, Z; Zhou, H | 1 |
| Ali, I; Aull, K; Boehm, D; Dirk, LM; Hanada, K; Houtz, R; Kaehlcke, K; Kamada, M; Ott, M; Pagans, S; Ramage, H; Sakane, N; Schnoelzer, M; Trievel, R; Weinberger, L | 1 |
| Deng, W; Ma, L; Ullah, S; Wang, Y; Xue, Y; Zhang, Y | 1 |
| Acurzio, B; Angelini, C; Anvar, Z; Cammisa, M; Feil, R; Fico, A; Grimaldi, G; Helin, K; Kukreja, H; Lad, S; Lonardo, E; Riccio, A; Riso, V; Sankar, A; Sparago, A; Verde, G | 1 |
| Cortopassi, WA; Duarte, F; Kumar, K; Paton, RS; Pimentel, AS | 1 |
| Deng, H; Feng, Q; Gao, T; He, B; Lei, Q; Song, X; Ye, T; Yu, L; Zhang, L; Zhu, Y | 1 |
| Earnshaw, WC; Kimura, H; Kugou, K; Larionov, V; Martins, NM; Masumoto, H; Nagase, T; Ohzeki, J; Otake, K; Shono, N | 1 |
| Guo, G; Ramadoss, S; Wang, CY | 1 |
| Dong, A; Guo, Z; Huang, H; Huang, Y; Li, B; Li, Y; Li, Z; Liu, J; Liu, Y; Shen, WH; Zhang, Y | 1 |
| Bisaro, DM; Coursey, T; Jackel, JN; Storer, JM | 1 |
| Bradner, J; Brown, M; Cheng, H; Dreijerink, KM; Groner, AC; Lin, CY; Ohlson, CE; Reyes, J; Roberts, TM; Spangle, JM; Zhao, JJ | 1 |
| Cai, Q; Casero, RA; Chen, H; Dou, Y; Jin, L; Jin, Y; Li, X; Liu, Y; Lu, J; Luo, H; Qiu, Y; Reisman, D; Seto, E; Shenoy, AK; Tang, M; Wu, L | 1 |
| Bunina, D; Gupta, I; Huber, F; Khmelinskii, A; Knop, M; Meurer, M; Steinmetz, LM; Theer, P | 1 |
| Antonoglou, A; Brown, PJ; Elkouris, M; Kontaki, H; Nikolaou, KC; Panayotou, G; Samiotaki, M; Saviolaki, D; Sideras, P; Stavropoulos, A; Szantai, E; Talianidis, I | 1 |
| Bi, C; Chng, WJ; Chung, TH; Lee, PT; Lee, XT; Li, B; Lin, B; Ng, SB; Selvarajan, V; Tan, J; Yan, J; Yang, H; Yu, Q | 1 |
| Chovatiya, GL; Gupta, S; Khade, B; Ravi, V; Sarate, RM; Waghmare, SK | 1 |
| Helin, K; Jensen, ON; Lee, CF; Ruminowicz, C; Schwämmle, V; Sidoli, S; Wu, X | 1 |
| Falnes, PØ; Jakobsson, ME; Moen, A | 1 |
| Alexander, SR; Fairbanks, AJ | 1 |
| Chen, Y; Chu, Y; Deng, H; Huang, L; Li, W; Liu, D; Liu, ZJ; Ma, J; Ouyang, S; Wang, T; Zhang, Z; Zhu, Y | 1 |
| Andreeff, M; Campbell, CT; Chevassut, T; Daigle, SR; Deng, L; Goodell, MA; Jeong, M; Kornblau, SM; Li, W; Luo, M; Rau, RE; Rodriguez, BA; Rogers, JH; Rosen, A; Song, Y; Sweet, S | 1 |
| Alabert, C; Bartke, T; Bekker-Jensen, S; Cejka, P; Forne, I; Foster, BM; Groth, A; Hammond, CM; Huang, H; Imhof, A; Mailand, N; Mlejnkova, L; Patel, DJ; Reverón-Gómez, N; Saredi, G | 1 |
| Knockleby, J; Kylie, K; Lee, H; Lindamulage, IK; Romero, J | 1 |
| Frye, SV; James, LI | 1 |
| Goda, N; Hachiya, R; Iwasaki, Y; Manabe, I; Matsumura, Y; Miyamoto, Y; Nakayama, Y; Ochi, K; Ogawa, Y; Oishi, Y; Sakai, J; Shiihashi, T; Shirakawa, I; Suganami, T; Tanaka, M | 1 |
| Akhtar, W; Beijersbergen, RL; de Vries, NA; Gisler, S; Gogola, E; Hulsman, D; Koppens, M; Lieftink, C; Miles, DC; Pawlitzky, I; Tanger, E; van Lohuizen, M | 1 |
| Gallo, JM; Pickard, AJ; Wang, T | 1 |
| Qiu, JD; Shi, SP; Wang, LN; Wen, PP; Xu, HD | 1 |
| Horvath, T; Lazar, T; Meszaros, A; Schad, E; Szabo, B; Tantos, A; Tompa, P | 1 |
| Chern, J; Chou, CC; Kuo, CH; Lai, MC; Lai, SJ; Liang, SY; Wu, SH; Wu, WL; Yang, JT | 1 |
| Balbach, ST; Orkin, SH | 1 |
| Brennan, P; Che, KH; Johansson, C; Nowak, RP; Oppermann, U; Owen, D; Tumber, A | 1 |
| Kutateladze, TG; Musselman, CA | 1 |
| Hof, F | 1 |
| Duncan, AL; Robinson, AJ; Walker, JE | 1 |
| Gober, IN; Waters, ML | 1 |
| Davydova, E; Falnes, PØ; Ho, A; Jakobsson, ME; Małecki, J | 1 |
| Liu, HM; Liu, Y; Ma, JL; Zheng, YC | 1 |
| Bieberstein, NI; Carrillo Oesterreich, F; Huranová, M; Kozáková, E; Krausová, M; Krchňáková, Z; Staněk, D; Thakur, PK | 1 |
| Arndt, KM; Martens, JA; Raupach, EA | 1 |
| Jones, JP; Kang, C; Ralph, J; Regner, M; Sattler, SA; Sattler, SE; Vermerris, W; Walker, AM | 1 |
| Huang, R; Huang, Y; Jiang, X; Li, M; Yang, X; Yao, J; Yu, M; Zheng, F | 1 |
| Boon, R; Collas, P; Eggermont, K; Helsen, N; Najimi, M; Pistoni, M; Sokal, E; Vanhove, J; Vanslembrouck, V; Verfaillie, CM; Voncken, JW; Welters, M | 1 |
| Chatdarong, K; Do, LT; Otoi, T; Sato, Y; Taniguchi, M; Techakumphu, M; Tharasanit, T; Wittayarat, M | 1 |
| Dohi, T; Endo, TA; Hattori, M; Kawamura, YI; Kitajima, M; Muro, R; Oda, H; Oshima, K; Otsubo, T; Shinkai, Y; Suzuki, H; Takai, T; Takikita, S; Toyoda, T; Weis, J | 1 |
| Hu, G; Li, J; Li, Q; Shan, S; Wang, C; Wang, J; Zhang, X | 1 |
| Bedford, MT; Blasius, TL; Chiang, YC; Davis, IJ; Dere, R; Fahey, CC; Hacker, KE; Ho, TH; Jonasch, E; Park, IY; Powell, RT; Rathmell, WK; Tripathi, DN; Verhey, KJ; Walker, CL | 1 |
| Burlingame, AL; Clark, AT; Daxinger, L; Du, J; Ho, J; Jacobsen, SE; Johnston, JB; Li, S; Liu, W; Pastor, WA; Patel, DJ; Shew, CJ; Stender, B; Yen, L | 1 |
| Giaccia, AJ | 1 |
| Brasier, AR; Sowers, LC; Tang, H; Tian, B; Zhang, K | 1 |
| Chen, W; Chung, HR; Dunkel, I; Fröhler, S; Gasparoni, G; Hamann, A; Helmuth, J; Kinkley, S; Polansky, JK; Walter, J | 1 |
| Li, G; Liu, X; Zhao, Y; Zhou, C; Zhou, DX; Zhou, Q; Zhou, S | 1 |
| Berger, SL; Dou, Z; Levine, AJ; Sammons, MA; Zhu, J | 1 |
| Chen, R; Cheng, H; Duan, X; Gao, S; Han, JD; Li, B; Li, G; Li, J; Wang, L; Wei, W; Wong, J; Wu, Q; Yu, W; Zhang, J; Zhao, Q; Zhu, H | 1 |
| Chamot-Rooke, J; Krupovic, M; Prangishvili, D; Rensen, E; Vorontsov, EA | 1 |
| Dorafshan, E; Kahn, TG; Pirrotta, V; Reim, I; Schultheis, D; Schwartz, YB; Stenberg, P; Zare, A | 1 |
| Daniel, B; Ding, J; Esquejo, RM; Foufelle, F; Khorasanizadeh, S; Li, X; Osborne, TF; Phelan, PE; Roqueta-Rivera, M; Sandor, K | 1 |
| Jeltsch, A; Kudithipudi, S | 1 |
| Kaikkonen, MU; Kurppa, K; Lindfors, K; Mäki, M; Oittinen, M; Popp, A; Viiri, K | 1 |
| Gao, F; Hou, H; Li, L; Ma, N; Wang, P; Wang, Q; Wen, H; Zhang, H; Zhou, H | 1 |
| Hof, F; Milosevich, N; Warmerdam, Z | 1 |
| Carlson, SM; Gozani, O | 1 |
| Dankert, D; Demond, H; Eichenlaub-Ritter, U; Grümmer, R; Heiligentag, M; Horsthemke, B; Trapphoff, T | 1 |
| Lee, US; Wagner, D; Xiao, J | 1 |
| Aanes, H; Bjørås, M; Dahl, JA; Dalen, KT; Fedorcsak, P; Greggains, GD; Hansen, K; Haugen, MH; Jermstad, I; Jung, I; Klungland, A; Kuan, S; Lee, AY; Lerdrup, M; Li, B; Li, G; Manaf, A; Preissl, S; Ren, B; Suganthan, R | 1 |
| Chen, J; Gao, H; Gao, S; Gao, Y; Kou, X; Li, C; Li, J; Liu, W; Liu, X; Wang, C; Wang, H; Zhang, Y; Zhao, Y | 1 |
| Chen, B; Gao, S; He, W; Huang, B; Kee, K; Kou, X; Li, C; Li, W; Li, Y; Liu, W; Ma, J; Meng, A; Ming, J; Na, J; Peng, X; Wang, Q; Wu, X; Xiang, Y; Xie, W; Xu, F; Xu, Q; Yin, Q; Zhang, B; Zhang, Y; Zhao, Y; Zheng, H | 1 |
| Ahmed, T; Baliyan, S; Balschun, D; Dotti, CG; Martin, MG; Martín-Segura, A; Palomer, E; Venero, C | 1 |
| Dohmae, N; Hamamoto, R; Matsuo, Y; Nakakido, M; Nakamura, Y; Simone, C; Suzuki, T; Tsurita, G; Watanabe, T; Yoshioka, Y | 1 |
| Baylin, SB; Block, KF; Easwaran, H; Pasini, A; Sen, S | 1 |
| Chen, ZJ; Han, F; Song, Q; Ye, W; Zhang, T; Zheng, D | 1 |
| Su, Z; Wang, C; Xu, W; Yi, X; Zhang, K; Zhang, W | 1 |
| Jiang, H; Khodadadi-Jamayran, A; Shah, K; Yang, Z | 1 |
| Cui, P; Guo, Q; Han, H; Li, C; Li, Q; Li, X; Liu, S; Sun, G | 1 |
| Bhat, UA; Chakravarty, S; Jhelum, P; Kumar, A; Maitra, S; Patel, AB; Pathak, SS; Rajan, WD | 1 |
| Gasser, SM; Kalck, V; Padeken, J; Tijsterman, M; van Schendel, R; Zeller, P | 1 |
| Chen, CY; Cheng, RP; Chiang, CH; Liu, MC; Wang, WM | 1 |
| Dai, KQ; Du, GY; Gou, XM; Li, H; Liu, Y; Yu, XY; Zhang, HS; Zhang, ZG; Zhou, Z | 1 |
| Pan, T; Schwartz, MH; Waldbauer, JR; Zhang, L | 1 |
| Bendixen, C; Farajzadeh, L; Kristensen, KK; Larsen, K; Momeni, J | 1 |
| Dey, M; Fardin-Kia, AR; Juenemann, RM; Liu, Y; Upadhyaya, B | 1 |
| Murakami, Y; Suzuki, S; Takahata, S | 1 |
| Antrobus, R; Dougan, G; Lehner, PJ; Tchasovnikarova, IA; Timms, RT | 1 |
| Dave, N; Di Croce, L; Díaz, VM; García de Herreros, A; Gutierrez-Gallego, R; Herranz, N; Iturbide, A; Jerónimo, C; Lórenz-Fonfría, V; Millanes-Romero, A; Morey, L; Pascual-Reguant, L; Peiró, S | 1 |
| Alavattam, KG; Andreassen, PR; Kato, Y; Kowalski, IJ; Maezawa, S; Namekawa, SH; Pang, Q; Sin, HS; Zhang, F | 1 |
| Botuyan, MV; Bruns, CJ; Cui, G; Klein, BJ; Kutateladze, TG; Lin, K; Lu, Y; Mer, G; Shi, X; Wang, X; Yuan, C; Zhao, Y | 1 |
| Gao, S; Liu, Y; Wang, Y; Zhao, X | 1 |
| Gupta, D; Kaur, I; Kaushik, A; Malhotra, P; Mohmmed, A; Saini, E; Zeeshan, M | 1 |
| Ascoli, AM; Casellas, R; Feng, X; Garcia, BA; Gutierrez-Cruz, G; Juan, AH; Knight, AL; Ko, KD; Krebs, J; Pedersen, RA; Sartorelli, V; Sidoli, S; Tsai, PF; Vivanco, KO; Wang, S; Zare, H; Zou, J | 1 |
| Cao, XJ; Garcia, BA | 1 |
| Dong, M; Jin, Y; Mao, J; Wang, K; Wang, Y; Ye, M; Zou, H | 1 |
| Cui, Y; Ding, H; Guo, C; Li, C; Peragine, A; Poethig, S; Wang, H; Wu, G; Xu, Y; Zheng, B; Zhou, B; Zhu, Z | 1 |
| Jäckel, S; Kahle, PJ; Schulze-Hentrich, J; Sugeno, N; Voigt, A; Wassouf, Z | 1 |
| He, H; Jiang, H; Lin, N; Liu, Y; Shen, Z; Wang, H; Yu, L; Yu, Q; Zeng, S; Zheng, X; Zhu, Q | 1 |
| Boersma, MD; Denu, JM; Krautkramer, KA; Kuznetsov, VI; Lee, JH; Miller, MD; Papazyan, R; Phillips, GN; Raman, A; Stephens, KE; Su, Z; Taverna, SD; Thorpe, JJ; Voronina, E; Wang, F | 1 |
| Bekker, A; Gu, X; Liang, L; Lutz, BM; Miao, X; Mo, K; Tao, YX; Wu, S; Xiao, J; Zhang, J; Zhao, JY | 1 |
| Dutta, D; Joseph, S; Majumder, A; Mukherjee, A; Pillai, MR; Syed, KM; Teixeira, JM | 1 |
| Jiang, L; Mao, H; Wang, Y; Xue, Z; Zhu, D | 1 |
| Gogol, MM; Li, H; Venkatesh, S; Workman, JL | 1 |
| Buratowski, S; Kim, JH; Kim, T; Kim, WK; Lee, BB; Lee, SB; Lee, Y; Oh, YM; Steinmetz, LM; Zhu, C | 1 |
| Agger, K; Ancelin, K; Anil-Kirmizitas, B; Bassett, A; Brockdorff, N; Cooper, S; Grijzenhout, A; Heard, E; Helin, K; Kooistra, SM; Nesterova, TB; Underwood, E; Zhang, T | 1 |
| Dai, S; Fang, X; Hsu, WW; Kurra, Y; Liu, WR; Tharp, JM; Vatansever, EC; Wang, X; Wang, ZA; Zeng, Y | 1 |
| Chin, KK; Collombet, S; Graf, T; Iberg-Badeaux, A; Laurent, B; Shi, Y; Thieffry, D; van Oevelen, C | 1 |
| Bishop, BC; Carter, BC; Gelvin, SB; Iwakawa, H; Ogas, J | 1 |
| Blum, G; Bothwell, IR; Kapilashrami, K; Linscott, JA; Luo, M; Senevirathne, C; Wang, Z | 1 |
| Fabbrizi, MR; Hallahan, DE; Meyer, B; Raj, S; Sharma, GG; Zobel, CL | 1 |
| Nalawansha, DA; Pflum, MK | 1 |
| Cervelli, JA; Fang, M; Gow, AJ; Kipen, H; Laskin, DL; Laskin, JD; Laumbach, RJ; Lioy, PJ; Massa, C; Sunil, VR; Vayas, KN; Zarbl, H | 1 |
| Aster, JC; Bernstein, BE; Cahill, DP; Carey, CD; Donohue, LK; Flavahan, WA; Gillespie, SM; Hebert, CH; Liau, BB; Miller, TE; Najm, FJ; Patel, AP; Rich, JN; Rodig, SJ; Shareef, SJ; Sievers, C; Suvà, ML; van Galen, P; Venteicher, AS; Wakimoto, H | 1 |
| Bonora, G; Chronis, C; Clark, AT; Jaenisch, R; Kim, R; Kuoy, E; Langerman, J; Plath, K; Sabri, S; Sahakyan, A; Theunissen, TW | 1 |
| Arkadir, D; Barnicoat, A; Barral, S; Ben-Pazi, H; Bergman, H; Bhate, S; Bhatia, KP; Boys, A; Carr, LJ; Carss, KJ; Chong, WK; Chubb, JR; Dale, RC; Darin, N; Foulds, N; Gahl, WA; Gissen, P; Grozeva, D; Gutowski, N; Heales, SJ; Hills, A; Houlden, H; Hurst, JA; Israel, Z; Joseph, AP; Kaminska, M; Kamsteeg, EJ; Kurian, MA; Limousin, P; Lin, JP; Lumsden, D; McKee, S; Mencacci, NE; Meyer, E; Misra, S; Mohammed, SS; Morrogh, D; Nakou, V; Ng, J; Ngoh, A; Nichols, JM; Nicolai, J; Nilsson, M; Pall, H; Papandreou, A; Peall, KJ; Perez-Dueñas, B; Peters, GB; Pittman, A; Pope, S; Prabhakar, P; Rankin, J; Raymond, FL; Reis, A; Reuter, MS; Rump, P; Segel, R; Sinnema, M; Smith, M; Topf, M; Toro, C; Turnpenny, P; White, SM; Wieczorek, D; Wiethoff, S; Willemsen, MA; Wilson, BT; Winter, G; Wood, NW; Wragg, C | 1 |
| Chen, J; Jia, Q; Luo, J; Seong, J; Singh, R; Sun, J; Tajik, A; Tan, Y; Wang, N; Wood, AR; Yang, F; Zhou, W | 1 |
| Beland, FA; Chen, T; de Conti, A; Dreval, K; Kindrat, I; Melnyk, S; Pogribny, IP; Shpyleva, S; Yan, J | 1 |
| Chen, DF; Dai, L; Jia, SN; Li, HW; Lin, C; Nagasawa, H; Wang, HL; Yang, F; Yang, JS; Yang, WJ; Ye, S | 1 |
| Beilharz, TH; Curtis, MJ; Dichtl, B; Geli, V; Harrison, PF; Hasan, Q; Holstege, F; Kalanon, M; Le, UM; Margaritis, T; Miles, DM; Saksouk, J; See, MM | 1 |
| Yin, J; Zhang, S; Zhong, J | 1 |
| Atadja, P; Dillon, MP; Fang, D; Feng, L; Fu, X; Gabriel, T; Gao, Z; Gu, J; Guo, H; Huang, Y; Jiang, X; Li, L; Lingel, A; Liu, X; Liu, Y; Mi, Y; Oyang, C; Qi, W; Shultz, MD; Sun, Y; Wang, L; Wang, Y; Yu, Z; Zeng, J; Zhang, C; Zhang, H; Zhang, J; Zhang, L; Zhang, M; Zhang, Q; Zhao, K; Zhao, M | 1 |
| Deng, X; Dohmae, N; Hamamoto, R; Kiyotani, K; Lingen, M; Matsuo, Y; Nakamura, Y; Park, JH; Saloura, V; Suzuki, T; Vougiouklakis, T; Zewde, M | 1 |
| Fang, D; Gan, H; Wang, H; Zhang, Z; Zhou, H | 1 |
| Kobayashi, A; Yamagata, K | 1 |
| Cui, J; Deng, W; Gao, J; Guan, KL; He, R; Ji, M; Jiang, B; Liu, P; Ma, S; Qiu, Z; Sun, R; Wu, X; Xiong, Y; Yang, P; Ye, D; Yi, W | 1 |
| Iglesias, N; Jeltsch, A; Kudithipudi, S; Kusevic, D; Moazed, D | 1 |
| Chakravarti, D; Chen, JR; Chen, P; Deng, P; DePinho, RA; Dey, P; Lan, Z; Li, J; Liang, X; Liao, W; Lu, X; Navone, NM; Shah, S; Shang, X; Spring, DJ; Tang, M; Troncoso, P; Wang, G; Wang, YA; Zhang, J; Zhao, D | 1 |
| Abe, K; Aiba, H; Hayashi, K; Higuchi, T; Miwa, S; Murakami, H; Rosario, M; Takeuchi, A; Taniguchi, Y; Tanzawa, Y; Tsuchiya, H; Yamamoto, N | 1 |
| Bronson, RT; Chick, JM; Geng, Y; Gygi, SP; Harper, JW; Inuzuka, H; Kołodziejczyk, A; Li, N; Ligon, KL; Liu, L; Meng, AY; Michowski, W; Nihira, NT; Ordureau, A; Polyak, K; Shimizu, K; Sicinski, P; Wei, W | 1 |
| Bouvet, P; Chen, J; Cong, R; Du, JX; Li, J; Shi, T; Wei, W; Wong, J; Wu, M | 1 |
| Denu, JM; Dowell, JA; Fieweger, R; Lu, L; Qian, S; Sanders, D; Zhong, X | 1 |
| Bertolino, P; Chanal, M; Cordier-Bussat, M; Gherardi, S; Goehrig, D; Hennino, A; Mikaelian, I; Ripoche, D; Teinturier, R; Zhang, CX | 1 |
| Dai, X; Fang, F; Fang, M; Song, M; Xu, Y; Yu, L | 1 |
| Basu, M; Chakrabarti, P; Das, C; Khan, MW | 1 |
| Botuyan, MV; Brault, ME; Chaubey, S; Chaudhuri, J; Chowdhury, D; Cui, G; Detappe, A; Drané, P; Harper, JW; He, Y; Kalousi, A; Meghani, K; Mer, G; Münch, C; Parnandi, N; Soutoglou, E; Yewdell, WT; Zheng, XF | 1 |
| Chen, P; Fung, H; Gu, Y; He, S; Hexner, E; Hu, S; Huang, J; Huang, Q; Jin, J; Jin, M; Li, C; Liu, Y; Ma, A; Reshef, R; Tian, Y; Tong, Q; Yu, H; Zhang, Y | 1 |
| Hino, S; Igata, T; Nakao, M; Nakatsu, Y; Saitoh, N; Sakamoto, A; Takebayashi, SI; Tanaka, H | 1 |
| Magnuson, T; Mu, W; Shibata, Y; Starmer, J; Yee, D | 1 |
| Brown, M; Chi, D; Cook, J; de Laat, W; Dreijerink, KMA; Font-Tello, A; Groner, AC; Gu, L; Lim, E; Lin, CY; Long, HW; Rao, PK; Reyes, J; Vos, ESM | 1 |
| Berger, MS; Lin, C; Lin, CA; Phillips, JJ; Rhodes, CT | 1 |
| Bouvet, P; Buschbeck, M; Cantariño, N; Corujo, D; Douet, J; Imhof, A; Malinverni, R; Mongelard, F; Posavec Marjanović, M; Renauld, J; Sansoni, V; Thiry, M; Valero, V | 1 |
| Bae, N; Bedford, MT; Bridgers, JB; Krajewski, K; Rothbart, SB; Sagum, C; Shanle, EK; Shinsky, SA; Strahl, BD | 1 |
| Biggar, KK; Connolly, J; Wu, Z | 1 |
| Cui, F; Fan, X; Gao, Y; Han, J; Ji, J; Li, J; Liu, L; Su, Q; Sun, L; Tong, Y; Zhang, N; Zhang, W | 1 |
| Ebina, M; Funayama, R; Igarashi, K; Itoh-Nakadai, A; Katoh, Y; Matsumoto, M; Nakayama, K; Sato, M; Sato, Y; Unno, M | 1 |
| Finkl, K; Laprell, F; Müller, J | 1 |
| Coleman, RT; Struhl, G | 1 |
| Jin, GH; Liu, JY; Lu, YH; Wang, HM; Wang, ZF; You, H; Zhang, L; Zhang, Q; Zheng, QF | 1 |
| Blitz, IL; Charney, RM; Cheung, J; Cho, JS; Cho, KW; Forouzmand, E; Paraiso, KD; Taira, M; Takahashi, S; Xie, X; Yasuoka, Y | 1 |
| Hoffmeyer, K; Junghans, D; Kanzler, B; Kemler, R | 1 |
| Barenton, B; Beaudoin, C; Billas, IM; Boudra, R; Carnesecchi, J; Carroll, JS; Cerutti, C; Forcet, C; Sérandour, AA; Tribollet, V; Vanacker, JM; Zhang, L | 1 |
| Cao, X; Chen, CC; Levasseur, D; Liang, H; Lu, J; McDee, D; Rivas-Astroza, M; Sloofman, L; Sridhar, B; Stormo, G; Tanaka, TS; Telugu, BPVL; Wang, Y; Xiao, S; Yu, P; Zhang, K; Zhao, JC; Zhao, T; Zhong, S | 1 |
| Kuang, Z; Sutter, BM; Tu, BP; Wang, Y; Ye, C | 1 |
| Brunet, A; Han, S; Hebestreit, K; Mair, WB; Schroeder, EA; Silva-García, CG | 1 |
| Carroll, J; Ding, S; Fearnley, IM; Rhein, VF; Walker, JE | 1 |
| Li, H; Liu, XY | 1 |
| Amezquita, RA; Gray, SM; Guan, T; Kaech, SM; Kleinstein, SH | 1 |
| Lane, RP; Meredith, D; Vyas, RN | 1 |
| Casas, E; Hidalgo-Carcedo, C; Klosin, A; Lehner, B; Vavouri, T | 1 |
| Ayoub, N; Brik, A; Guttmann-Raviv, N; Jbara, M; Maity, SK | 1 |
| Dong, A; Pinon, V; Shen, WH; Yao, X | 1 |
| Aoshima, K; Kimura, T; Okada, Y | 1 |
| Hadden, MK; Teske, KA | 1 |
| Boehm, D; Camus, G; Deeks, SG; Godin, R; Gramatica, A; Greene, WC; Hull, PA; Jeng, M; Johnson, JR; Krogan, NJ; Montano, M; Ott, M; Pagans, S; Sakane, N; Schwarzer, R | 1 |
| Liu, WR; Wang, ZA | 1 |
| Capovilla, G; Krajewski, P; Langenecker, T; Neher, RA; Neumann, M; Posé, D; Sawikowska, A; Schmid, M; You, Y | 1 |
| Falnes, PØ; Jakobsson, ME; Leidel, SA; Malecki, J; Moen, A; Nilges, BS | 1 |
| Brown, KC; Chan, RC; Csankovszki, G; Feng, S; Freeberg, MA; Gu, SG; Jacobsen, SE; Kalinava, N; Khanikar, J; Kim, JK; Montgomery, TA; Snyder, MJ; Weiser, NE; Yang, DX | 1 |
| Allègre, J; Berthelet, J; Boidot, R; Boutanquoi, PM; Cartier, J; Droin, N; Dubrez, L; Dumetier, B; Garrido, C; Gemble, S; Glorian, V; Gonzalez, D; Kayaci, C; Marcion, G; Michaud, O; Solary, E | 1 |
| Li, L; Wang, Y | 1 |
| Dougan, G; Douse, CH; Kingston, RE; Lehner, PJ; Modis, Y; Roberts, RC; Tchasovnikarova, IA; Timms, RT | 1 |
| Hyun, KG; Noh, YS; Song, JJ | 1 |
| Cheng, Z; Fu, X; Hao, T; Hu, X; Huo, B; Jin, Y; Zhang, Y; Zhu, J | 1 |
| Casacuberta, JM; Costas, C; Gutierrez, C; Hénaff, E; Morata, J; Peiró, R; Sequeira-Mendes, J; Vergara, Z | 1 |
| Bratkowski, M; Liu, X; Yang, X | 1 |
| Bansal, V; Chen, W; Cui, H; Dall'Agnese, A; Dorn, C; Gatto, S; Grunert, M; Latella, L; Malecova, B; Puri, PL; Ryan, T; Schulz, K; Sperling, SR | 1 |
| Fulton, MD; He, M; Ho, MC; Zhang, J; Zheng, YG | 1 |
| Cruz, C; Houseley, J; Hull, RM; Jack, CV | 1 |
| Brooks, AN; Carlson, SM; Elias, JE; Gozani, O; Soulette, CM; Yang, Z | 1 |
| Hamey, JJ; Quinlan, KGR; Wienert, B; Wilkins, MR | 1 |
| Albano, F; Bavaro, L; Calogero, R; Cavo, M; Ciceri, F; De Benedittis, C; Delledonne, M; Elena, C; Fontana, MC; Gangemi, D; Guadagnuolo, V; Haferlach, T; Mancini, M; Manfrini, M; Martinelli, G; Meggendorfer, M; Merante, S; Morigi, F; Padella, A; Pagano, L; Papayannidis, C; Poletti, G; Riccioni, L; Rondoni, M; Savini, P; Scaffidi, L; Soverini, S; Specchia, G; Tosi, P; Valent, P; Zago, E; Zanotti, R | 1 |
| Chao, SH; Ho, SCL; Ng, S; Soo, BPC; Tay, J; Yang, Y | 1 |
| Cho, KS; Kim, JH; Lee, IS; Lee, JH; Lee, SB | 1 |
| de Lichtenberg, C; Huang, L; Nguyen, TTTN; Rand, KD; Schwarz-Linnet, T; She, Q; Stiefler-Jensen, D; Teilum, K | 1 |
| Bordignon, V; Lindquist, AG; Marinho, LSR; Rissi, VB; Seneda, MM | 1 |
| Ha, SC; Jeong, JH | 1 |
| Dinesh-Kumar, SP; Ma, S; Snyder, M | 1 |
| Chen, LT; Hsu, MC; Hung, WC; Pan, MR | 1 |
| Chen, M; Hu, H; Liu, P; Tan, M; Zhai, L; Zhang, M | 1 |
| Colmenares, SU; Costes, SV; Karpen, GH; Kennedy, C; Langley, SA; Swenson, JM | 1 |
| Paavilainen, S; Pakharukova, N; Tuittila, M; Zavialov, A | 1 |
| Liu, J; Liu, X; Ma, X; Qu, P; Su, J; Wang, M; Wang, Y; Zhang, J; Zhang, Y; Zhou, C | 1 |
| Adelmant, G; Amouroux, R; Arita, K; de Dieuleveult, M; Defossez, PA; Deng, W; Dohmae, N; Ferry, L; Filion, GJ; Fournier, A; Fritsch, L; Hajkova, P; Jeltsch, A; Kirsh, O; Kudithipudi, S; Leonhardt, H; Marto, JA; Matano, S; Shimazu, T; Shinkai, Y; Suzuki, T; Tsusaka, T | 1 |
| Jeong, BC; Koh, JT; Park, J; Yang, JW | 1 |
| Aghaloo, T; Deng, P; Hong, C; Szymanski, JM; Wang, CY; Yu, B; Yu, Y | 1 |
| Bedford, MT; Carr, SM; Fedorov, O; La Thangue, NB; Munro, S; Sagum, CA | 1 |
| Feil, R; Pathak, R | 1 |
| Cho, K; Park, HS; Yang, A | 1 |
| Jiang, DS; Jiang, X; Li, X; Yi, X | 1 |
| Aygün, O; Carr, SA; Dvela-Levitt, M; Greka, A; Ostrosky-Frid, M; Sieber, J; Udeshi, ND; Wieder, N | 1 |
| Jensen, ON; Kempf, SJ; Rogowska-Wrzesinska, A; Schwämmle, V; Tvardovskiy, A | 1 |
| Olp, MD; Smith, BC; Zhu, N | 1 |
| Slama, P | 1 |
| Abhishek, S; Nakarakanti, NK; Nivya, MA; Rajakumara, E; Satish, M; Shivani, D; Vani, MV | 1 |
| Dairi, T; Hamano, Y; Maruyama, C; Niikura, H; Ogasawara, Y; Shin-Ya, K | 1 |
| Byrum, S; Fowler, FC; Pal, S; Tackett, AJ; Tyler, JK; Wang, P | 1 |
| Das, C; Dasgupta, D; Roy, S; Sanyal, S; Sen, S; Srivastava, DK | 1 |
| Bulic, M; Dupéré-Richer, D; Ezponda, T; Huang, X; Keats, J; Kelleher, N; Licht, JD; Maji, S; Nabet, B; Occhionorelli, M; Oyer, J; Patel, T; Popovic, R; Riva, A; Shah, MY; Small, EC; Tonon, G; Varghese, N; Will, CM; Zheng, Y | 1 |
| Ahringer, J; Carelli, FN; Sharma, G | 1 |
| Casanova, AG; Lemonnier, N; Reynoird, N; Roth, GS | 1 |
| Cao, X; Li, N; Wang, C; Wang, Q; Xie, B; Xu, X; Zhao, Y | 1 |
| Kociucka, B; Stachecka, J; Szczerbal, I; Szydlowski, M | 1 |
| Gozda, K; Khorshid Ahmad, T; Kong, J; Lakowski, TM; Lillico, R; Namaka, M; Stesco, N; Truong, J; Zhou, T | 1 |
| Mino, T; Takeuchi, O | 1 |
| Altelaar, AFM; Bleijerveld, OB; de Krijger, I; Fortunato, D; Hoekman, L; Jacobs, JJL; Moatti, N; Serrat, J; Simonetta, M | 1 |
| Meehan, RR; Pennings, S | 1 |
| Lee, K; Park, OS; Seo, PJ | 1 |
| Al Temimi, AHK; Belle, R; Brown, T; Dunford, JE; Hopkinson, RJ; Johansson, C; Kawamura, A; Kumar, K; Mecinović, J; Oppermann, U; Paton, RS; Pieters, BJGE; Schofield, CJ; Tumber, A | 1 |
| Dong, A; Jiang, Y; Li, L; Li, Z; Ma, M; Peng, M; Shen, WH; Zhou, N | 1 |
| Biggar, KK; Li, SS; Wang, Z | 1 |
| Cao, X; Chen, W; Chen, X; Deng, X; Du, J; He, K; Hu, H; Jia, B; Li, S; Qiu, Q; Tao, WA; Yang, Z | 1 |
| Fujii, K; Izumi, Y; Matsuo, K; Namatame, H; Taniguchi, M; Yokoya, A | 1 |
| Mandler, MD; Nanan, KK; Oberdoerffer, S; Ocheltree, C; Prigge, M; Sturgill, D; Varma, G | 1 |
| Ahmad, R; Huang, S; Liu, B; Liu, Y; Meng, Q; Wang, J; Xu, ZY; Yin, H; Yu, X; Zhang, A | 1 |
| Chen, ZJ; Jiang, S; Jiao, W; Liu, M; Liu, Y; Wang, L; Wang, X; Ye, W; Yuan, J; Zheng, D | 1 |
| Li, Q; Ma, F; Wang, G; Wang, X; Wang, Y; Wu, X; Xu, H; Yang, B; Zhang, F; Zhang, R; Zhang, X; Zhang, Z | 1 |
| Adams, AT; Chiang, YC; Choudhury, R; Churchman, LS; Dominguez, D; Dronamraju, R; Emanuele, MJ; Eser, U; Jha, DK; Rathmell, WK; Strahl, BD | 1 |
| Dai, B; Guan, F; Hu, Z; Huang, H; Mao, B; Su, H; Xiao, Z; Zhu, G | 1 |
| Bardwell, VJ; Deng, J; Gearhart, MD; Hernandez, C; Ivanova, NB; Jin, J; Kluger, Y; Kumar, I; Lee, YW; Lu, AY; Neubert, TA; Neuenkirchen, N; Ramazanov, B; Wang, Z; Zhang, Y | 1 |
| Chen, X; Lu, L; Qian, S; Scalf, M; Smith, LM; Zhong, X | 1 |
| Balan, S; Dohmae, N; Furuse, T; Hamakubo, T; Iwanari, H; Okuno, S; Shimazu, T; Shinkai, Y; Suzuki, T; Wakana, S; Yamada, I; Yoshikawa, T | 1 |
| Ducker, GS; Gitai, Z; Li, SH; Mayer, JA; Morscher, RJ; Rabinowitz, JD; Sperl, W | 1 |
| Dhayalan, A; Jeltsch, A; Knodel, F; Rawłuszko-Wieczorek, AA; Tamas, R | 1 |
| Cai, J; Dinislam, M; Duan, C; Gao, F; Gao, W; Han, B; Jiang, C; Kang, C; Lin, L; Meng, X; Wang, R; Wu, P | 1 |
| Chen, LT; Chen, Y; Deng, M; Dong, M; Dong, ZW; Gao, L; Huang, QH; Jia, XE; Jin, Y; Liu, TX; Ren, CG; Wang, J; Wang, L; Xu, PF; Yu, SH; Yuan, H; Zhang, F; Zhou, Y; Zhu, J; Zhu, KY; Zon, LI | 1 |
| Hawkins, LJ; Storey, KB; Wijenayake, S | 1 |
| Alonso, AP; Chandler, CN; Cocuron, JC; Cooper, GL; Huseby, CJ; Kuret, J | 1 |
| Colby, AH; Grinstaff, MW; Liu, K; Lu, C; Oberlies, NH; Pearce, C; Sabbatini, ME; Yang, D | 1 |
| Ding, LH; Gao, SB; Jin, GH; Liu, JY; Ni, GY; Qiu, H; Wang, HM; Xu, B; Ye, J; Zhang, L; Zheng, QF; Zhu, LY | 1 |
| Caplan, MR; Haynes, KA; LaBaer, J; Song, L; Tekel, SJ; Vargas, DA | 1 |
| Berger, MS; Cardona, AE; Cardona, SM; Huang, SA; Lemmon, VP; Lin, CA; Rhodes, CT; Zunino, G | 1 |
| Dhawan, D; Dörken, B; Elkahloun, A; Holmen, SL; Ji, S; Kemper, K; Lee, S; Li, L; Lohneis, P; Mallette, FA; Meierjohann, S; Peeper, DS; Qutob, N; Reimann, M; Samuels, Y; Schleich, K; Schmitt, CA; Silvis, MR; Speck, C; Treitschke, S; van Rooijen, E; Werner-Klein, M; Yu, Y; Yue, B; Zon, LI | 1 |
| Falnes, PØ; Jakobsson, ME; Małecki, J | 1 |
| Casati, P; Dotto, M; Gómez, MS; Soto, MS | 1 |
| Chen, D; Cheng, L; Liu, Y; Wang, Y; Xiao, L; Yan, N; Zhang, J; Zheng, S | 1 |
| Camphausen, K; Rath, BH; Tofilon, PJ; Waung, I | 1 |
| Duo, S; Feng, C; Ji, F; Jiao, J; Li, Y; Qiao, H | 1 |
| Alkhayer, K; Clements, R; Freeman, E; McDonough, J; Shelestak, J; Singhal, NK | 1 |
| Churko, JM; Guo, H; Karakikes, I; Kim, Y; Kitani, T; Lee, J; Paik, DT; Shao, NY; Snyder, MP; Termglinchan, V; Wilson, KD; Wu, H; Wu, JC; Zhang, Y; Zhao, MT | 1 |
| Bondar, NP; Ershov, NI; Lepeshko, AA; Merkulova, TI; Reshetnikov, VV; Ryabushkina, JA | 1 |
| Bassil, AK; Dobenecker, MW; Gregory, R; Knight, SD; Marcello, J; McCabe, MT; Park, JS; Prinjha, RK; Rioja, I; Tarakhovsky, A | 1 |
| Akiyoshi, M; Ichiyanagi, K; Kimura, H; Kitano, S; Kuroki, S; Maeda, R; Miyachi, H; Nakai, Y; Nakato, R; Okashita, N; Shinkai, Y; Shirahige, K; Tachibana, M; Yamaguchi, Y | 1 |
| Benevento, M; Dubos, A; Feil, R; Habibi, E; Herault, Y; Iacono, G; Kasri, NN; Kleefstra, T; Mandoli, A; Méziane, H; Riet, F; Selloum, M; Stunnenberg, HG; van Bokhoven, H; Zhou, H | 1 |
| Chen, Z; Jiang, R; Lee, KY; Meneghini, MD | 1 |
| Ding, X; Feng, X; Jin, X; Liang, G; Lin, F; Liu, Q; Luo, Y; Song, H; Wang, L; Wu, Q; Xu, X; Yu, T; Zhang, M; Zhang, Z | 1 |
| Chen, ES; Li, AY; Lim, KK; Nguyen, TTT; Yeo, YP | 1 |
| Arnold, EP; Haile, S; Hulleman, E; Kadapakkam, M; Labanieh, L; Mackall, CL; Majzner, RG; Monje, M; Mount, CW; Rietberg, SP; Sundaresh, S; Vogel, H; Woo, PJ | 1 |
| Garza, N; Jin, VX; Kornblau, S; Li, T; Liu, Q | 1 |
| Antonik, PM; Crowley, PB; Dalcanale, E; Guagnini, F; Khan, AR; O'Byrne, P; Pinalli, R; Rennie, ML | 1 |
| Armache, KJ; Dobenecker, MW; Ganai, RA; Grau, D; Holder, M; Lee, CH; LeRoy, G; Reinberg, D; Saldaña-Meyer, R; Wang, M; Yu, JR; Zhang, J | 1 |
| Mishima, Y; Shimizu, M; Suetake, I; Takada, S; Watanabe, S | 1 |
| Li, W; Shi, J; Shi, L; Shi, X; Wen, H | 1 |
| Chiang, YC; Chowdhury, P; Davis, IJ; de Cubas, AA; Dere, R; Fahey, CC; Karki, M; Khan, A; Mason, FM; Ohi, R; Park, IY; Parker, JS; Powell, RT; Rathmell, WK; Shuster, CB; Sohn, BH; Strahl, BD; Terzo, EA; Tripathi, DN; Tsai, YS; Walker, CL | 1 |
| Arend, RC; Jones, BA; Varambally, S | 1 |
| Broun, A; Froimchuk, E; Gavrilova, O; Ge, K; Jain, S; Jang, Y; Lee, JE; Liu, C; Park, YK; Zhuang, L | 1 |
| Funatsu, T; Suzuki, R; Tsunoda, M | 1 |
| Bröhm, A; Buchrieser, C; Jeltsch, A; Kudithipudi, S; Rolando, M; Schuhmacher, MK; Weirich, S | 1 |
| Itoh, Y; Kakizawa, T; Ota, Y; Suzuki, T | 1 |
| Guo, K; Guo, Z; Li, J; Li, Z; Liu, P; Lu, J; Wang, J; Wang, P; Ye, J; Zhong, Y | 1 |
| Dai, Z; Gao, X; Locasale, JW; Mentch, SJ; Nichenametla, SN | 1 |
| Bao, S; Cai, W; Ding, Y; Li, M; Li, Z; Sun, Y; Xie, Q; Yin, R; Zhou, T | 1 |
| Allard, P; Camacho, J; Chen, YW; Gutierrez, G; Kurt, Z; Morselli, M; Pellegrini, M; Truong, L; Yang, X | 1 |
| An, W; Kim, J; Kim, K; Shin, Y; Ulmer, TS | 1 |
| Bao, L; Chen, Y; Chiang, CM; Fontenot, M; Hatanpaa, KJ; Lai, HT; Lega, B; Luo, W; Raisanen, JM; Semenza, GL; Wang, JE; Wang, Y; Wu, SY | 1 |
| Chen, ZQ; Cheng, L; Czajkowsky, DM; Dai, J; Hou, S; Huang, JG; Jiang, HW; Jiang, S; Liu, CX; Qi, H; Sun, YY; Tao, SC; Wang, JF; Zhou, YM | 1 |
| Lee, SS; Pu, M; Velayudhan, SS; Wang, M; Wang, W | 1 |
| Chen, H; Fan, J; Lu, Y; Lv, X; Pan, C; Wu, H; Wu, W; Xia, Y; Zhang, L; Zhang, S; Zhang, Z; Zhao, Y | 1 |
| Moazed, D; Wang, X; Yu, R | 1 |
| Chen, G; Li, L; Li, Z; Lu, D; Rong, Y; Singh, V; Smith, S; Wang, E; Xiao, Y; Yang, D; Yang, L; Ye, Y; Zhang, W; Zhang, Y; Zhou, J; Zhou, L | 1 |
| Alban, C; Bourguignon, J; Ravanel, S; Serre, NBC | 1 |
| Blumenberg, L; Descostes, N; Garcia, BA; Karch, K; Lee, CH; LeRoy, G; Narendra, V; Oksuz, O; Raviram, R; Reinberg, D; Rocha, PP; Skok, JA | 1 |
| Bordin, AI; Bourquin, JR; Cohen, ND; Dindot, SV; Doan, RN; Hillman, PR; Kuskie, KR; McQueen, CM; Whitfield, CM | 1 |
| An, W; Jeong, D; Kim, J; Kim, K; Kim, M; Koh, J; Lee, S; Lu, JF; Punj, V; Shin, H; Shin, Y; Ulmer, TS | 1 |
| Cui, Y; Kassab, MA; Liu, X; Ma, Y; Wang, J; Wang, M; Wu, C; Xie, R; Yang, G; Yu, X; Yuan, Z | 1 |
| Chen, J; Chen, L; Fang, H; Fang, L; Ge, X; Han, D; Jiao, C; Jin, J; Jin, X; Li, C; Li, Y; Liao, G; Liao, L; Liu, M; Liu, Z; Peng, X; Qin, HL; Teng, H; Wang, P; Wang, X; Wang, Y; Wei, Q; Weng, L; Yang, Y; Zhang, S; Zhao, B; Zhou, D; Zhou, J | 1 |
| Afenjar, A; Bienvenu, T; Billuart, P; Giurgea, I; Goldenberg, A; Hamroune, J; Lebrun, N; Mietton, L; Saintpierre, B | 1 |
| Ding, J; Wang, H; Xu, Y; Yang, Y | 1 |
| Chan, KM; Chan, SY; Chong, CH; Liu, H; Mak, PHS; Peng, L; So, J; Tsang, KH | 1 |
| Fan, H; Feng, J; Li, J; Liu, C; Meng, Z; Peng, Y; Wang, L; Yuan, L; Zhao, W; Zheng, Q | 1 |
| Arora, V; Green, A; Jaganathan, A; Mezei, M; Mujtaba, S; Ohlmeyer, M; Patel, J; Pierre-Louis, V; Rehmann, J; Vincek, AS; Zhou, MM | 1 |
| Alexander, WS; Dawson, CA; Dekkers, JF; Hu, Y; Jamieson, PR; Joyce, RM; Lindeman, GJ; Michalak, EM; Milevskiy, MJG; Orkin, SH; Pal, B; Smyth, GK; Visvader, JE | 1 |
| Antunes, L; Carvalho, S; Freitas, M; Henrique, R; Jerónimo, C; Monteiro-Reis, S; Paulino, S; Tavares, A; Videira, JF; Vieira-Coimbra, M | 1 |
| Imai, Y; Inoue, K; Kanoh, M; Kuwahara, M; Matsuda, S; Nabe, S; Suzuki, J; Takemori, A; Takemori, N; Yamada, T; Yamashita, M; Yasukawa, M | 1 |
| Gruber, T | 1 |
| Chen, W; Du, J; Harris, CJ; Jacobsen, SE; Jia, B; Li, S; Li, X; Liu, R; Wang, Z; Zhong, Z | 1 |
| Berr, A; Neyt, P; Shen, WH; Van Lijsebettens, M; Zhao, W | 1 |
| Bao, F; Chan, WY; Chen, K; Duan, L; Gao, M; He, X; Li, L; Lin, X; Liu, X; Long, Q; Lv, Y; Pei, D; Tang, H; Wang, Y; Wu, Y; Xiang, G; Xing, G; Yang, L; Ying, Z; Zhao, Q; Zheng, L; Zhou, Y | 1 |
| Aram, R; Lee, JT; Saltzman, AL; Soo, MW | 1 |
| Bitton, R; Feldman, M; Kublanovsky, M; Levy, D; Morgenstern, D; Shmidov, Y; Weil, LE | 1 |
| Andrews, CA; Chan, MP; Kahana, A; Rao, RC | 1 |
| Cockrum, C; Garcia, BA; Jensen, ON; Kreher, J; Sidoli, S; Strome, S; Takasaki, T | 1 |
| Fukamizu, A; Kako, K; Kim, JD | 1 |
| Han, D; Li, X; Lu, J; Ma, M; Ma, Y; Tan, J; Wang, Y; Xu, G; Yao, R; Zhao, Y | 1 |
| Bi, J; Cai, Q; Chen, C; Dong, W; He, W; Huang, J; Jiang, N; Li, H; Lin, T; Liu, H; Su, F; Wang, B; Zhang, B; Zhao, Y; Zhong, G | 1 |
| Gu, J; Hu, J; Jin, Y; Li, S; Liao, B; Sun, X; Tang, F; Wang, H; Xiao, F; Zeng, Y; Zhang, J; Zhao, Y | 1 |
| Salz, HK; Shapiro-Kulnane, L; Smolko, AE | 1 |
| Bovio, PP; Franz, H; Heidrich, S; Kilpert, F; Manke, T; Rauleac, T; Vogel, T | 1 |
| Branco, MR; Chrysanthou, S; Darbo, E; Hemberger, M; Mifsud, B; Schoenfelder, S; Senner, CE; Todd, CD | 1 |
| Bonini, NM; Kennerdell, JR; Liu, N | 1 |
| Bradley, EW; Camilleri, ET; Dudakovic, A; Galeano-Garces, C; Im, HJ; Karperien, M; Krych, AJ; Larson, AN; McGee-Lawrence, ME; Paradise, CR; Riester, SM; van Wijnen, AJ; Westendorf, JJ | 1 |
| Bartkuhn, M; Burgold, T; Hake, SB; Hendrich, B; Imhof, A; Keilhauer, EC; Lindström, I; Link, S; Low, JKK; Mackay, JP; Mann, M; Nist, A; Pünzeler, S; Regnard, C; Sana, M; Spitzer, RMM; Stiewe, T; Torrado, M; Völker-Albert, MC | 1 |
| Chen, P; Fan, H; Guo, D; Li, Y; Qian, Q; Sun, R | 1 |
| Atashpaz, S; Barbagiovanni, G; Boesch, S; Broccoli, V; Caiazzo, M; D'Antonio-Chronowska, A; Germain, PL; Haslinger, B; Jech, R; Lo Riso, P; Stewart, AF; Tenderini, E; Testa, G; Winkelmann, J; Zech, M | 1 |
| Guan, S; Ma, R; Pan, Y; Wang, C; Wu, M; Xiong, Y; Yao, J; Zang, J; Zhan, L; Zhang, X | 1 |
| Bai, L; Li, G; Liu, X; Song, L; Yang, L | 1 |
| Alhaj Abed, J; Benes, J; Frolov, A; Ghotbi, E; Jones, RS; Ye, P | 1 |
| Endo, M; Hayashi, Y; Kanno, S; Kiso, K; Kobayashi, H; Kono, T; Koseki, H; Maeda, I; Matsui, Y; Mochizuki, K; Nakai, Y; Okuda, A; Tachibana, M; Tatsumi, D; Yasui, A; Yoshioka, T | 1 |
| Hard, R; He, W; Komives, E; Li, N; Mo, GCH; Peng, Q; Ross, B; Stein, RSL; Wang, W; Wang, Y; Zhang, J | 1 |
| He, XH; Lei, MZ; Lei, QY; Liang, YL; Qu, J; Wang, D; Wang, YP; Yan, WW; Zhang, QX | 1 |
| Li, N; Liu, B; Liu, Y; Meng, X; Qi, X; Wang, TJ; Wang, X; Xu, ZY; Yu, X; Zhang, A | 1 |
| Ashe, A; Boag, PR; Buchmann, G; Harney, DJ; Hoe, M; Larance, M; Low, JKK; Woodhouse, RM | 1 |
| Biggar, KK; Rowe, EM; Xing, V | 1 |
| Adhvaryu, KK; Bicocca, VT; Honda, S; Ormsby, T; Selker, EU | 1 |
| Brunzelle, J; Cornett, EM; Cowles, MW; Dickson, BM; Krajewski, K; Rothbart, SB; Shaw, KM; Spellmon, N; Sun, ZW; Umstead, A; Vaughan, RM; Vega, IE; Versluis, PP; Yang, Z | 1 |
| Gamble, MJ; Ruiz, PD | 1 |
| Alves-Wagner, AB; Correa-Giannella, ML; Esteves, JV; Giannella-Neto, D; Machado, UF; Okamoto, MM; Yonamine, CY | 1 |
| Burgering, BMT; Eijkelkamp, N; Falnes, PØ; Ho, AYY; Kjønstad, IF; Małecki, JM; Moen, A; Pinto, R; Willemen, HLDM; Zwartkruis, F | 1 |
| Arimura, Y; Handa, T; Harada, A; Hayashi-Takanaka, Y; Kimura, H; Kurumizaka, H; Maehara, K; Nogami, J; Ohkawa, Y; Shirahige, K | 1 |
| Khan, HM; MacKerell, AD; Reuter, N | 1 |
| Chatterjee, M; Dworak, N; Jividen, K; Johnson, IG; Kelley, JB; Makosa, D; Paschal, BM; Simke, WC; Snow, C; Yang, CS | 1 |
| Bui, HT; Ho, NTK; Nguyen, TV; Nguyen, TVT | 1 |
| Li, L; Li, R; Wang, Y | 1 |
| Bassik, MC; Caporicci, M; Carlson, SM; Elias, JE; Francis, JW; Fuentes, ME; Gozani, O; Hausmann, S; Hulea, L; Kim, MP; Li, A; Liu, S; Lofgren, SM; Lu, J; Maitra, A; Mazur, PK; Nguyen, ND; Pillai, R; Porco, JA; Song, J; Tandoc, K; Topisirovic, I; Van Rechem, C; Wang, H; Wistuba, II | 1 |
| Bachmann, AL; Fierz, B; Guidotti, N; Lechner, CC | 1 |
| Elia, N; Feldman, M; Goliand, I; Levy, D; Vershinin, Z | 1 |
| Chen, H; Cheng, Q; Huang, R; Li, S; Qian, Y; Shao, Z; Wang, H; Xiang, M; Xie, R; Xu, N; Xu, Q; Zhou, Z | 1 |
| Cao, Q; Chen, GJ; Cheng, J; Lin, L; Liu, A; Ma, K; Matas, E; Wang, W; Wang, X; Wang, ZJ; Wei, J; Yan, Z; Zhang, F; Zheng, Y | 1 |
| Li, Z; Luan, W; Lv, W; Ma, P; Ma, X; Su, L; Yang, S; Zhang, M; Zhang, S; Zhu, Y | 1 |
| Cai, Z; Chen, TY; Gao, Y; Han, F; Hou, Z; Hsu, CC; Hu, J; Jin, G; Lan, J; Lee, MG; Li, H; Lin, HK; Long, J; Sun, L; Wang, G; Wang, YH; Xu, C; Yang, SC; Zhang, W | 1 |
| Duronio, RJ; Leatham-Jensen, M; Matera, AG; McKay, DJ; Strahl, BD; Uyehara, CM | 1 |
| Fukuda, M; Miyawaki, A; Sakaue-Sawano, A; Shimura, C; Shinkai, Y; Tachibana, M | 1 |
| Duan, X; Guo, X; Shen, Y; Tian, Z; Yao, L | 1 |
| Aleström, P; Ballangby, J; Brede, DA; Hurem, S; Kamstra, JH; Lindeman, LC; Lyche, JL; Martín, LM; Oughton, DH; Salbu, B; Teien, HC | 1 |
| Botaitis, S; Franco, R; Mantso, T; Mitsiogianni, M; Panayiotidis, MI; Pappa, A; Trafalis, DT; Vasantha Rupasinghe, HP; Zoumpourlis, V | 1 |
| Storey, KB; Watts, AJ | 1 |
| Chen, Y; Fan, H; Li, Y; Lin, S; Qian, Y; Zhao, Z; Zhou, M | 1 |
| Gupta, R; Saha, P; Sen, N; Sen, T | 1 |
| Bartke, T; Becker, JR; Beyer, TE; Cesa, LC; Chapman, JR; Faull, PA; Foster, BM; Frimurer, T; Groth, A; Lukauskas, S; Nakamura, K; Nguyen, NV; Saredi, G | 1 |
| Dorafshan, E; Glotov, A; Kahn, TG; Reuter, G; Savitsky, M; Schwartz, YB; Walther, M | 1 |
| Shankar, SR; Srinivasan, S; Taneja, R; Wang, Y | 1 |
| Auer, F; Chen, J; Chen, Z; Deng, X; Dong, L; Dong, Y; Du, J; Guan, JL; He, C; Hu, YC; Huang, G; Huang, H; Jiang, X; Klemm, L; Li, C; Liu, J; Lu, Z; Mesquita, A; Müschen, M; Qin, H; Qin, X; Qing, Y; Qu, L; Shen, C; Su, R; Sun, M; Sun, W; Tao, S; Wei, M; Weng, H; Wu, H; Wu, T; Wu, X; Xiao, G; Yang, J; Yin, H; Yuan, CL; Zhao, BS; Zhou, K; Zhou, Y; Zuo, Z | 1 |
| Alenina, N; Bader, M; Bastle, RM; Berton, O; Bhanu, NV; Erikson, G; Farrelly, LA; Gage, FH; Garcia, BA; Heard, KJ; Lepack, AE; Li, H; Loh, YE; Lukasak, BJ; Lyu, Y; Maze, I; Molina, H; Muir, TW; Nakadai, T; Ramakrishnan, A; Roeder, RG; Shen, L; Thompson, RE; Vadodaria, KC; Zebroski, H; Zhang, B; Zhao, S | 1 |
| Batie, M; Frost, J; Frost, M; Rocha, S; Schofield, P; Wilson, JW | 1 |
| Feng, L; Hong, F; Zhang, L; Zhao, M | 1 |
| Clyde, D | 1 |
| Allis, CD; Bagert, JD; Feng, L; Gao, J; Kundra, R; Lemiesz, AE; Muir, TW; Nacev, BA; Schultz, N; Soshnev, AA | 1 |
| Huang, X; Liu, L; Pan, B; Tian, J; Wang, Z; Wu, X; Zhao, W | 1 |
| Greenberg, MM; Prasse, C; Yang, K | 1 |
| Chen, Y; Chu, X; Han, D; Huang, M; Lei, Z; Li, Z; Liu, C; Wang, T | 1 |
| Guo, HS; Liu, X; Zhao, J | 1 |
| Helin, K; Højfeldt, JW; Laugesen, A | 1 |
| Aslan, JE; Babur, Ö; Cunliffe, JM; David, LL; Klimek, J; McCarty, OJT; Melrose, AR; Ngo, ATP; Pang, J; Rocheleau, AD; Tassi Yunga, S | 1 |
| Cai, GY; Gan, YM; Gu, T; Hong, LJ; Li, ZC; Liu, W; Quan, R; Wu, ZF; Zheng, EQ; Zhou, J | 1 |
| Connolly, LR; Freitag, M; Happ, K; Happel, P; Haueisen, J; Möller, M; Schotanus, K; Smith, KM; Soyer, JL; Stralucke, M; Stukenbrock, EH | 1 |
| Bollenbach, A; Brunner, G; Hanff, E; Tsikas, D | 1 |
| Chen, S; Kapilashrami, K; Linscott, JA; Luo, M; Senevirathne, C; Wang, J; Wang, Z | 1 |
| Guo, J; Wei, W | 1 |
| Allen, A; Cottard, F; Einsle, O; Greschik, H; Hermann, B; Hornung, V; Imhof, A; Jung, M; Maurer, J; Metzger, E; Obier, N; Offermann, A; Perner, S; Preca, BT; Schmidt, A; Schüle, R; Sum, M; Ulferts, S; Urban, S; Wang, S; Willmann, D | 1 |
| Abe, S; Ishiuchi, T; Kamimura, S; Ohishi, H; Sasaki, H; Sato, T; Suyama, M; Suzuki, A; Wakayama, T; Yorino, M | 1 |
| Liu, Z; Wang, K; Wang, Q; Wang, Y; Ye, M | 1 |
| Liu, H; Wang, Z | 1 |
| Alsolami, M; Alsulami, M; Cagney, G; Cotter, D; Dillon, E; Moss, C; Munawar, N; Ó Gaora, P; O'Meara, F; Oliviero, G; Wynne, K | 1 |
| Cong, Z; Cui, L; Guo, X; Li, Q; Yang, Y; You, T | 1 |
| Al Temimi, AHK; Guo, H; Mecinović, J; Proietti, G; Qian, P; van der Wekken-de Bruijne, R | 1 |
| Levy, D | 1 |
| Itakura, K; Yamakawa, T | 1 |
| Kang, J; Kim, J; Lee, S | 1 |
| Dai, X; Dai, Z; Yang, Y | 1 |
| Bochyńska, A; Braunschweig, T; Chatain, N; Costa, IG; Denecke, B; Koschmieder, S; Kuo, CC; Lüscher, B; Lüscher-Firzlaff, J; Ullius, A | 1 |
| Kutateladze, TG; Zhang, Y | 1 |
| Shechter, D | 1 |
| Chen, X; Du, Y; Gu, L; Jiang, C; Li, W; Liu, WJ; Sun, J; Ye, Y; Zhang, X | 1 |
| Eijkelkamp, N; Falnes, PØ; Ho, AYY; Małecki, JM; Moen, A; Pinto, R; Willemen, HLDM | 1 |
| Anderson, MS; Cortez, JT; Eckalbar, WL; Erle, DJ; Sin, JH; Waterfield, MR; Zuckerman, C | 1 |
| Fan, M; Shi, X | 1 |
| Di Ruscio, A; Fry, CJ; Hoffman, JR; Li, J; Tan, HK; Tan, ZH; Tenen, DG; Wu, CS; Yang, H | 1 |
| Andrade, G; Basso, CG; Cechinel, LR; de Meireles, LCF; de Souza Grefenhagen, ÁI; Galvão, F; Lovatel, GA; Nestler, EJ; Palazzo, RP; Siqueira, IR; Walker, DM | 1 |
| Brown, TM; Daze, KD; Dev, A; Douglas, SF; Hirsch, AKH; Hof, F; Milosevich, N; Monjas, L; Simhadri, C; Wulff, JE | 1 |
| Abdollahi, M; Das, S; Jia, Y; Lanting, L; Natarajan, R; Oh, HJ; Reddy, MA; Wang, M; Yuan, H; Zhang, E | 1 |
| Angrisani, A; Belloni, L; De Smaele, E; Levrero, M; Lupacchini, L; Pediconi, N; Peruzzi, G; Salerno, D | 1 |
| Barlev, NA; Loboda, AP; Piacentini, M; Soond, SM | 1 |
| Chen, D; Chen, S; Gao, X; Liu, H; Meng, M; Zhang, J; Zhao, H | 1 |
| Dong, H; Sun, B; Wang, Y; Zhang, J; Zhang, Q | 1 |
| Li, J; Li, Z; Liu, H; Liu, W; Wan, J; Yang, Q; Zhang, M | 1 |
| Chen, J; Chen, Q; Gao, M; Gu, J; Guo, L; Huang, K; Kang, B; Li, D; Li, J; Li, Y; Liang, Z; Liao, B; Long, B; Mai, Y; Nie, J; Pan, G; Pei, D; Shan, Y; Shu, X; Su, S; Wang, J; Wang, P; Wang, Q; Wang, T; Wu, C; Wu, F; Zhang, T; Zhang, X; Zhang, Y; Zhao, S; Zhong, X; Zhu, Y | 1 |
| Cheng, C; Gao, WQ; Hou, J; Ji, Z; Li, L; Li, X; Liu, K; Miao, J; Shen, L; Sheng, Y; Sun, J; Wang, J; Wang, X; Xu, L; Yao, J; Zhang, K; Zhao, H; Zhou, W; Zhu, HH | 1 |
| Cai, J; Huang, M; Huang, S; Jiang, Y; Li, Y; Liu, J; Mei, Z; Niu, S; Wang, J; Ye, P; Zhao, S; Zhong, Y; Zou, H | 1 |
| Butler, AA; Cash, AE; Henderson, BW; Herskowitz, JH; Huang, V; Irwin, AB; Lubin, FD; Pepin, ME; Webb, WM; Wende, AR | 1 |
| Cheng, X; Dai, S; Gozani, O; Horton, JR; Wilkinson, AW; Woodcock, CB; Zhang, X | 1 |
| Asara, JM; Campbell, SL; Haviv, S; Ikeda, Y; Iwase, S; Kahoud, ER; Kawaguchi, R; Kofuji, K; Kofuji, S; Majd, N; Malhotra, A; Okumura, K; Popov, KI; Randhawa, J; Sasaki, AT; Sasaki, M; Shimada, H; Temple, B; Wolfe, K; Yin, G; Yoshino, H | 1 |
| Aebersold, R; Allali-Hassani, A; Arrowsmith, CH; Duan, S; Faini, M; Fan, L; Fang, X; Houliston, S; Kaustov, L; Lemak, A; Li, F; Vedadi, M; Wang, Y; Wei, Y; Wu, H; Zeng, H | 1 |
| Chen, J; Hu, Y; Jin, H; Yang, P; Yu, Y; Zhang, L | 1 |
| Ben-Yair, R; Boyer, LA; Burns, CE; Burns, CG; Busby, M; Butty, VL; Goren, A; Levine, SS; Qiu, Y | 1 |
| Anderson, A; Aubert, Y; Capell, BC; Doepner, M; Egolf, S; Ko, EK; Lan, Y; Lee, J; Maldonado-Lopez, A; Pacella, G; Ridky, T; Simpson, CL; Zou, J | 1 |
| Ayyappan, V; Bhide, KP; Fiedler, E; Kalavacharla, VK; Saha, MC; Sripathi, VR; Thimmapuram, J | 1 |
| Chen, M; Hao, W; Zhang, X | 1 |
| Alonso, AP; Cocuron, JC; Cooper, GL; Hoffman, CN; Huseby, CJ; Kuret, J; Thomas, SN; Yang, AJ | 1 |
| Bousard, A; Chang, HY; da Rocha, ST; Gil, C; Heard, E; Picard, C; Pires, VB; Qi, Y; Raposo, AC; Syx, L; Żylicz, JJ | 1 |
| Ekwall, K; Kurumizaka, H; Machida, S; Nakagawa, R; Nakayama, JI; Nishibuchi, G; Oya, E; Shirai, A; Tagami, H; Tanaka, M; Yoshimura, Y | 1 |
| Aben, M; Andralojc, KM; Cairns, BR; Chrispijn, ND; Elurbe, DM; Jansen, PWTC; Kamminga, LM; Murphy, PJ; Rougeot, J; Vermeulen, M | 1 |
| Burdorf, RM; Cech, TR; Gooding, AR; Lee, T; Long, Y; Paucek, RD; Wang, X | 1 |
| Andrade, J; Garcia, BA; Granat, J; Jin, Y; Lee, CH; LeRoy, G; Lund, P; Reinberg, D; Saldaña-Meyer, R; Stafford, JM; Ueberheide, B; Yu, JR | 1 |
| Arora, S; Horne, WS; Islam, K | 1 |
| Cornett, EM; Defossez, PA; Ferry, L; Rothbart, SB | 1 |
| Aravin, AA; Fejes Tóth, K; Ninova, M | 1 |
| Akke, M; Ishida, H; Modig, K; Vogel, HJ; Weininger, U | 1 |
| Andrechek, ER; Daldoul, K; Harris, LN; Hirukawa, A; Lavoie, C; Muller, WJ; Park, M; Rennhack, JP; Sanguin-Gendreau, V; Singh, S; Smith, HW; Swiatnicki, M; Varadan, V; Wang, J; Westbrook, TF; Zuo, D | 1 |
| Garcia, BA; Lehman, SM; Lund, PJ | 1 |
| Bae, YS; Park, JW | 1 |
| Boccaccini, A; Costantino, P; Costi, R; Dello Ioio, R; Di Santo, R; Longo, C; Lorrai, R; Madia, VN; Ruta, V; Sabatini, S; Saccoliti, F; Tudino, V; Vittorioso, P | 1 |
| Albanese, KI; Brustad, EM; Krone, MW; Parker, MM; Petell, CJ; Strahl, BD; Waters, ML | 1 |
| Green, EM; Jethmalani, Y | 1 |
| Hanasaki, M; Masumoto, H | 1 |
| Bjørås, M; Dahl, JA; Klungland, A; Li, Y; Manaf, A; Perez, SP; Suganthan, R; Zhang, Z | 1 |
| Anselmo, A; Bernstein, BE; Brumbaugh, J; Charlton, J; Choi, J; Coffey, A; Di Stefano, B; Hochedlinger, K; Hock, H; Huebner, AJ; Ji, F; Kim, IS; Meissner, A; Sadreyev, RI; Schindler, JW; Schwarz, BA; Walsh, RM | 1 |
| Akinwole, A; Green, EM; Ikram, S; Jaiswal, D; Moresco, JJ; Ramaprasad, G; Turniansky, R; Wolf, J; Yates, JR | 1 |
| Feng, D; Gao, J; Gao, T; Hou, Y; Huang, W; Leng, S; Liu, R; Liu, W; Qiu, R; Wang, S; Wang, Y; Yang, Y; Yu, W; Zeng, Y; Zhang, K; Zhang, X; Zheng, Y | 1 |
| Cato, T; Chanfreau, GF; Clarke, SG; Deramchi, N; Gabunilas, J; Roy, KR; Wang, C; White, JT | 1 |
| Das, C; Gadad, SS; Klein, BJ; Kutateladze, TG; Mondal, P; Roy, S; Sen, S; Tiwary, N | 1 |
| Awasthi, S; Chavali, PL; Chavali, S; Dhayalan, A; Govindaraju, G; Khan, MIK; Mahesh, A; Rajavelu, A; Verma, M | 1 |
| Alban, C; Bourguignon, J; Choulet, J; Corso, M; Figuet, S; Gigarel, O; Ravanel, S; Rofidal, V; Santoni, V; Sarthou, M; Serre, NBC; Verbruggen, N | 1 |
| Bonaldi, T; Ghini, F; Giambruno, R; Maniaci, M; Massignani, E; Mihailovich, M; Nicassio, F; Patuzzo, F; Spadotto, V | 1 |
| Batista, RA; Figueiredo, DD; Köhler, C; Moreno-Romero, J; Qiu, Y; Santos-González, J; van Boven, J | 1 |
| Liu, HY; Liu, MY; Sun, HL; Zhang, HS; Zhou, Z | 1 |
| An, S; Ayoub, A; Cho, US; Cianfrocco, MA; Dou, Y; Kim, H; Lee, YT; Park, SH; Sha, L; Su, M; Xu, J; Zhang, B; Zhang, Y; Zheng, W | 1 |
| Geng, Q; Jiang, L; Li, L; Liang, M; Liang, Q; Wang, W; Zhang, C | 1 |
| Carpenter, BS; David, HS; Engstrom, AK; Katz, DJ; Lee, TW | 1 |
| Ali, HR; Ambardekar, AV; Cleveland, JC; Fritz, KS; Jeong, MY; Lin, YH; McKinsey, TA; Michel, CR; Reisdorph, N; Reisdorph, R; Woulfe, KC | 1 |
| Hao, B; Hu, H; Li, B; Liu, P; Sun, M; Tan, M; Xu, JY; Zhai, L; Zhang, M; Zhao, L; Zhao, X | 1 |
| Ali, M; Cao, J; Chen, PR; Chu, L; Chu, Y; Dou, Z; Du, S; Fang, G; Gao, X; Gui, P; Ismail, H; Liu, X; Mo, F; Wang, J; Wang, Q; Wang, W; Ward, T; Wu, H; Yang, F; Yao, X; Ye, M; Yu, R; Zang, J; Zhao, Y | 1 |
| Chang, L; Chen, P; Chen, X; Deng, H; Jin, C; Li, G; Li, T; Long, H; Lv, M; Margueron, R; Pei, J; Wang, X; Wen, Z; Wu, G; Yang, F; Zhang, L; Zhang, P; Zhang, W; Zhu, M | 1 |
| Adhikary, H; Biggar, KK; Chopra, A; Willmore, WG | 1 |
| Matsushita, K; Tamura, M; Ukita, M; Yamaguchi, T | 1 |
| Casanova, AG; Chuffart, F; Lukinović, V; Reynoird, N; Roth, GS | 1 |
| Athanàsio, CG; Brown, JB; Colbourne, JK; Kvist, J; Mirbahai, L; Pfrender, ME | 1 |
| Cho, SG; Choi, DY; Choi, HJ; Choi, Y; Choi, YJ; Chung, HM; Do, JT; Hong, K; Hong, SH; Jang, H; Kim, JH; Kong, G; La, HW; Lee, DR; Lee, OH; Lee, YJ; Moon, EH; Park, C; Park, JH; Saur, D; Son, D; Song, H; Yoo, H | 1 |
| Biggar, KK; Burke, GL; Chen, Z; Chopra, A; Greenblatt, JF; Lee, KY; Meneghini, MD | 1 |
| Cao, Z; Chen, Y; Hou, T; Li, Y; Lu, X; Tang, M; Tian, Y; Wang, H; Wang, L; Wang, Z; Wei, FZ; Yang, Y; Zhang, J; Zhao, Y; Zhu, WG | 1 |
| Chen, H; Chen, L; Chen, SR; Luo, Y; Pan, HL; Zhang, G; Zhang, J | 1 |
| Chen, Y; Gui, X; Jia, S; Jiang, X; Li, J; Li, T; Li, X; Lu, D; Lu, Y; Meng, Q; Pu, H; Song, S; Wang, C; Wang, L; Xie, S; Xin, X; Xu, J; Yang, Y | 1 |
| Al Temimi, AHK; Blaauw, RH; Mecinović, J; Mulders, MJM; Rutjes, FPJT; van der Linden, NGA; Wegert, A; White, PB | 1 |
| Chen, J; Hooley, RJ; Lee, J; Sarkar, P; Xue, M; Zhong, W | 1 |
| Biggar, KK | 1 |
| Choi, JH; Lee, H | 1 |
| Chen, J; Huang, K; Li, J; Li, R; Sun, R; Wang, Y; Xie, K; Yang, Q; Zhang, T; Zhang, Y; Zhao, Q; Zou, L | 1 |
| Cai, SQ; Chang, SY; Chen, Z; Cheng, X; Gao, G; Hao, P; Jiang, L; Jiang, Q; Kang, XL; Lin, DY; Liu, XJ; Liu, ZY; Ye, SW; Yin, JA; Yin, SG; Yuan, J | 1 |
| Chu, JW; Im, H; Kim, H; Lee, JM; Park, IG; Park, SC; Song, H | 1 |
| Corbière, V; Desmet, R; Lecher, S; Locht, C; Loyens, M; Mascart, F; Melnyk, O; Petit, E; Segers, J | 1 |
| Bao, J; Li, Z; Qi, Y; Zhang, JZH | 1 |
| Abe, Y; Aburatani, H; Furukawa, T; Glass, CK; Higashijima, Y; Inoue, T; Kanki, Y; Kimura, H; Li, G; Link, VM; Matsui, Y; Miura, M; Nagai, N; Nakaki, R; Nangaku, M; Osaka, M; Ruan, X; Ruan, Y; Shimamura, T; Taguchi, A; Tanaka, T; Tsutsumi, S; Wada, Y; Watanabe, R; Yoshida, M | 1 |
| Dong, H; Huang, L; Li, S; Liang, Y; Lin, S; Liu, Y; Zhou, D; Zhou, H | 1 |
| Blank, B; Buchner, J; Jokisch, ML; Kaila, VRI; Lang, K; Lawatscheck, J; Luo, Q; Mader, SL; Rehn, A; Richter, K; Tippel, F | 1 |
| da Silva, MS; Elias, MC; Janzen, CJ; Moretti, NS; Nunes, VS; Schenkman, S | 1 |
| Lilienthal, AJ; Long, A; Manak, JR; Nukala, KM; Parida, M; Santana, JF; Wankum, J | 1 |
| Barlev, N; Daks, A; Fedorova, O; Nader, R; Petukhov, A; Shuvalov, O; Vasileva, E | 1 |
| McNaught, KJ; Selker, EU; Wiles, ET | 1 |
| Coleman, PD; Guo, J; Labaer, J; Liao, R; Mastroeni, D; Pham, T | 1 |
| Czogalla, B; Han, N; Hester, A; Jeschke, U; Kuhn, C; Mahner, S; Mayr, D; Rottmann, M; Schmoeckel, E; Trillsch, F | 1 |
| Cheng, M; Hu, G; Wuyun, Q; Zhang, Y; Zheng, W | 1 |
| Inada, H; Kimura, R; Mochizuki, K; Osumi, N; Tatehana, M | 1 |
| Chen, M; Gao, S; Gu, L; Jiang, C; Kou, X; Li, C; Li, Y; Liu, X; Wang, H; Xu, R; Yang, L; Zhao, Y; Zhu, Q | 1 |
| Li, H; Li, Y; Zhou, L | 1 |
| Huang, H; Jiang, QA; Jin, X; Ma, L; Sun, L; Wang, JH; Yang, X; Zhang, C | 1 |
| Al Temimi, AHK; Bickelhaupt, FM; Hintzen, JCJ; Kumar, K; Mecinović, J; Paton, RS; Pieters, BJGE; Poater, J | 1 |
| Bae, HJ; Buratowski, S; Dargemont, C; Dubarry, M; Geli, V; Jeon, J; Kim, J; Soares, LM | 1 |
| Kim, CH; Kim, H; Kim, HR; Kim, SY; Lee, TG | 1 |
| Chai, P; Fan, J; Fan, X; Ge, S; Jia, R; Ni, H; Wang, S; Wang, Y; Xing, Y; Yu, J | 1 |
| Bartom, ET; Cao, K; Douillet, D; Helmin, KA; Marshall, SA; Morgan, MA; Piunti, A; Rendleman, EJ; Ryan, C; Shah, AP; Shilatifard, A; Singer, BD; Smith, ER; Sze, CC; Ugarenko, M; Zha, D; Zhao, Z | 1 |
| Do, BR; Ha, DH; Han, SY; Jeon, J; Jung, NR; Kim, CG; Kim, MY; Lee, S; Lee, SW; Lee, YJ; Lim, CS; Na, I; Son, SH; Uversky, VN | 1 |
| Bettridge, JT; Desiderio, S; May, MR | 1 |
| Abe, R; Furukawa, Y; Hino, S; Kaneko, H; Kobayashi, M; Nakao, M; Takeuchi, M; Tamaoki, J; Wada, T | 1 |
| Beldar, S; Dong, C; James, LI; Lamb, KN; Li, Y; Li, Z; Liu, Y; Lyu, TJ; Min, J; Qin, S; Tempel, W; Wang, Y | 1 |
| de Krijger, I; Eder, M; Jacobs, JJL; Peuscher, MH; van der Torre, J | 1 |
| Cheng, L; Li, L; Liang, Y; Liu, M; Wang, R; Xia, J; Yue, L; Zhang, L; Zhang, N | 1 |
| Abnousi, A; Bazeley, P; Hu, M; Liu, CF; Moravec, CS; Morley, M; Ni, Y; Tang, WHW | 1 |
| Fan, H; Li, Y; Lu, T; Mao, Y; Qian, Y; Sun, R; Yu, S; Zhang, Z; Zheng, C | 1 |
| Chen, TQ; Chen, YQ; Fang, K; Han, C; Huang, W; Luo, XQ; Pan, Q; Sun, LY; Sun, YM; Wang, D; Wang, WT; Yang, QQ; Zeng, ZC | 1 |
| Chatterjee, C; Delachat, AM; Dhall, A; Fierz, B; Leonen, CJA; Shelton, PMM | 1 |
| Bellacosa, A; Cai, KQ; Chau, LQ; Cheng, Y; Contreras, A; Corney, DC; Du, F; Guo, D; Hu, J; Liao, S; Noronha, AM; Peri, S; Wang, Y; Wechsler-Reya, RJ; Wiest, DL; Xu, G; Yang, ZJ; Zhao, Y; Zhou, G | 1 |
| Carlson, SM; Elias, JE; Gozani, O; Li, TM; Zhang, L; Zoabi, M | 1 |
| Doan, LT; Fruman, DA; Hanse, EA; Ishak Gabra, MB; Kong, M; Li, H; Lowman, XH; Schones, DE; Senapati, P; Tran, TQ; Xu, X; Yang, Y; Zhang, L | 1 |
| Li, P; Wang, J; Xu, X; Zhang, B; Zhang, J | 1 |
| Adhikary, H; Biggar, KK; Charih, F; Chopra, A; Connolly, J; Fang, Q; Frensemier, K; Galka, M; Green, JR; Hoekstra, M; Li, SS; Liu, H; Ruiz-Blanco, YB; Stalker, L; Stanford, WL; Wynder, C | 1 |
| Cai, L; Çetin, B; Coan, JP; Cui, Q; Detrick, B; Fan, H; Gao, L; Gozani, O; Grimm, SA; Guo, Y; Kim, JJ; Li, L; Miller, KM; O'Leary, SE; Patel, DJ; Petell, CJ; Ren, W; Song, J; Strahl, BD; Tan, XF; Wade, PA; Wang, GG; Wang, Y; Yin, J; Zhang, ZM | 1 |
| Dai, SK; Du, HZ; Liu, C; Liu, CM; Tang, QY; Teng, ZQ; Wang, YY; Zhang, SF | 1 |
| Alaggio, R; Alexandrescu, S; Lidov, HG; Ligon, KL; Meredith, DM; Novello, M; Vargas, SO | 1 |
| Chen, N; Huang, S; Huang, Y; Li, Z; Zhang, Y | 1 |
| Chen, Y; Gong, F; Li, Y; Peng, C; Tian, X; Zhao, L | 1 |
| Cole, PA; Wang, ZA | 1 |
| Chu, X; Cooper, DB; Gu, Y; Lewis, DF; McCathran, CE; Morgan, JA; Sheng, W; Wang, Y | 1 |
| Anlaş, AA; Nelson, CM | 1 |
| Jiao, H; Li, Z; Xie, Y | 1 |
| Diekwisch, TGH; Fallah, P; Foyle, D; Francis, M; Gonzalez, M; Gopinathan, G; Luan, X | 1 |
| Banda, A; Bayliss, J; Bian, Z; Blüml, S; Chinnaiyan, AM; Chung, C; Cieslik, M; Hawes, D; Judkins, AR; Koschmann, C; Lee, HJ; Lyssiotis, CA; Panwalkar, P; Pratt, D; Qin, T; Shan, M; Shotwell, JB; Sweha, SR; Tamrazi, B; Venneti, S; Wahl, DR; Werner, CK; Yadav, VN; Yang, F | 1 |
| Alaggio, R; Alisi, A; Castellano, A; D'Oria, V; De Stefanis, C; Francalanci, P; Giovannoni, I; Grimaldi, C; Romito, I | 1 |
| Guo, F; Li, Z; Liu, J; Liu, Y; Ma, X; Meng, D; Qin, G; Wang, J; Wu, L; Xu, L; Zhang, H; Zhang, L; Zhao, D; Zhao, S; Zhao, Y | 1 |
| Li, X; Mao, L; Zhang, J; Zhang, Y | 1 |
| Caggiano, R; Di Bonito, M; Di Mauro, A; Faraonio, R; Feola, A; Gigantino, V; Porcellini, A; Romano, A; Zuchegna, C | 1 |
| Gamu, D; Gibson, WT | 1 |
| Becker, A; Bhanu, NV; Carrol, T; Dobenecker, MW; Garcia, BA; Marcello, J; Prinjha, R; Rudensky, E; Tarakhovsky, A; Yurchenko, V | 1 |
| Lei, H; Tao, K | 1 |
| Bosgana, P; Bravou, V; Dimitrakopoulos, FI; Kalophonos, C; Kourea, E; Logotheti, S; Nikou, S; Sampsonas, F; Tzelepi, V; Zolota, V | 1 |
| Huang, T; Jiang, G; Lyu, L; Xiang, W; Yuan, J; Zhang, C; Zheng, F | 1 |
| Aicher, SA; Cho, H; Emery, B; Kim, D; Kim, S; Lee, JW; Lee, S; Lee, SK; Lim, SJ; McCane, M; Moon, JH; Park, Y; Wang, W; Yoon, SM | 1 |
| Beldar, S; Bröhm, A; Jeltsch, A; Khella, MS; Ludwig, J; Min, J; Schuhmacher, MK; Tempel, W; Weirich, S | 1 |
| Cianfrocco, MA; Dere, R; Jangid, RK; Jung, SY; Karki, M; Kearns, SE; Mason, FM; Millis, BA; Park, IY; Rathmell, WK; Seervai, RNH; Tripathi, DN; Tyska, MJ; Verhey, KJ; Walker, CL | 1 |
| Albecka, A; Douse, CH; Freund, SMV; Lehner, PJ; Modis, Y; Prigozhin, DM; Protasio, AV; Seczynska, M; Tchasovnikarova, IA; Timms, RT; Wagstaff, J; Williamson, JC | 1 |
| Hamzink, MRJ; Jiskoot, W; Kersten, GFA; Meiring, HD; Metz, B; Michiels, TJM; Schöneich, C | 1 |
| Bear, JE; Davis, IJ; Hepperla, AJ; Keele, GR; Kuhlman, B; Lerner, AM; Meriesh, HA; Restrepo, D; Strahl, BD; Yumerefendi, H; Zimmerman, S | 1 |
| Chen, Y; Cheng, T; Cheng, X; Chu, Y; Guan, J; Guo, H; Li, M; Shi, D; Shi, J; Wang, B; Wang, X; Xue, C; Yuan, W | 1 |
| Hu, H; Muntean, AG; Peterson, LF; Ropa, J; Saha, N; Talpaz, M | 1 |
| Allis, CD; Deshmukh, S; Garcia, BA; Jabado, N; Jain, SU; Juretic, N; Khazaei, S; Lewis, PW; Lu, C; Lundgren, SM; Marchione, DM; Wang, X; Weinberg, DN | 1 |
| Dumeaux, V; Kimmins, S; Lafleur, C; Lismer, A; Siklenka, K | 1 |
| Cao, K; Liang, K; Marshall, SA; Ozark, PA; Rendleman, EJ; Shilatifard, A; Smith, ER; Ugarenko, M; Wang, J; Wang, L; Yue, F; Zou, L | 1 |
| Bedford, MT; Berryhill, CA; Dickson, BM; Eden, HE; Foley, CA; Frye, SV; Krajewski, K; Kupai, A; Patel, V; Rothbart, SB; Sagum, CA; Shaw, KM; Strahl, BD; Tibben, BM; Tiedemann, RL; Vaughan, RM | 1 |
| Chen, S; Cheng, X; Fang, W; Hao, H; Hu, X; Hua, F; Huang, D; Huang, Z; Li, Q; Liu, F; Luo, Z; Xiao, F; Zhang, X | 1 |
| Klonou, A; Markouli, M; Papavassiliou, AG; Piperi, C; Strepkos, D | 1 |
| Cao, Q; Chen, K; Cooke, JP; Gao, X; Lee, MG; Lv, J; Meng, Q; Tomoiaga, AS; Wang, G; Xia, B; Yi, Y; Zhang, L; Zhang, M; Zhao, D; Zhu, S | 1 |
| Fukao, S; Haniuda, K; Kitamura, D | 1 |
| Krepl, M; Pokorná, P; Šponer, J | 1 |
| Ke, Y; Lan, M; Li, J; Li, X; Liang, X; Qin, H; Qing, G; Sheng, Q; Wang, C; Wang, X; Xiong, Y; Ye, M | 1 |
| Coller, HA; Corvalan, AZ | 1 |
| Bareke, E; Chen, H; Coradin, M; Garcia, BA; Harutyunyan, AS; Horth, C; Jabado, N; Krug, B; Lu, T; Majewski, J; Marchione, DM; Nikbakht, H; Russo, C | 1 |
| Liao, J; Szabó, PE | 1 |
| Bonora, G; Deng, X; Disteche, CM; Duan, Z; Fang, H; Filippova, GN; Henikoff, S; Lewandowski, JP; Noble, WS; Rinn, JL; Shendure, J; Thakur, J | 1 |
| Agnihotri, S; Bridge, T; Hawkins, C; Huang, A; Kim, B; Li, C; Milos, S; Pajovic, S; Patel, P; Phillips, L; Rakopoulos, P; Ryall, S; Sheth, J; Siddaway, R; Srikanthan, D; Yu, M | 1 |
| Chen, C; Du, J; Duan, CG; Jiang, J; Peng, L; Wang, Y; Xie, SS; Yuan, J; Zhang, G; Zhang, L; Zhang, YZ; Zhu, JK | 1 |
| Chlamydas, S; Markouli, M; Piperi, C; Strepkos, D | 1 |
| Al Temimi, AHK; Boltje, TJ; Buijs, R; Mecinović, J; Merx, J; Proietti, G; Rutjes, FPJT; van Noortwijk, CJ; White, PB | 1 |
| Al-Hamdani, Y; Rahman, S; Tkatchenko, A; Varma, S; Wineman-Fisher, V | 1 |
| An, N; Chen, XJ | 1 |
| Mahesh, S; Nwajiobi, O; Raj, M; Streety, X | 1 |
| Barshop, W; Bradley, LM; Finlay, D; Garcia, G; Gimple, RC; Hope, JL; Qiu, Z; Rantala, J; Rich, JN; Sangfelt, O; Shen, JZ; Spruck, C; Sun, D; Wohlschlegel, J; Wu, Q | 1 |
| Biggar, KK; Charih, F; Green, JR | 1 |
| Foroozani, M; Smith, AP; Vandal, MP | 1 |
| Bhat, KP; Gozani, O; Jin, J; Ümit Kaniskan, H | 1 |
| Chuh, KN; Dul, BE; Farrelly, LA; Li, H; Liu, X; Maze, I; Muir, TW; Roeder, RG; Thompson, RE; Xu, N; Xue, Y; Zhang, B; Zhao, S | 1 |
| Cook, DE; Huang, J; Zhang, W | 1 |
| Andrews, S; Ficz, G; Halsall, JA; Krueger, F; Reik, W; Rutledge, CE; Turner, BM | 1 |
| Anwar, T; Gonzalez, ME; Kleer, CG | 1 |
| Hayakawa, T; Hiratani, I; Kuriya, K; Ogata, M; Ogata, S; Okano, M; Okumura, K; Ryba, T; Sakaue, M; Takahashi, S; Takebayashi, SI; Wimbish, K | 1 |
| Allis, CD; Chen, H; Chen, X; Lu, C; Majewski, J; Rajagopalan, KN; Weinberg, DN | 1 |
| Chachar, S; Geng, Y; Gu, X; Guo, W; Liu, Q; Riaz, A; Wang, Y; Wu, C; Yan, S; Yang, L; Yang, Y; Yi, K; Zhang, P; Zhu, C | 1 |
| Angrisano, T; Cozzolino, F; Iacobucci, I; Monaco, V; Monti, M | 1 |
| Li, Z; Qin, H; Wang, K; Wang, Q; Wang, Y; Ye, M; Zhou, J | 1 |
| Damle, M; Kim, J; Kingston, RE; Miller, SA | 1 |
| Gabrielsen, OS; Myklebost, O; Røhr, ÅK; Stabell, M; Sæther, T | 1 |
| Jeon, M; Kim, H; Lee, JM; Park, IG | 1 |
| Irwin, B; Kueh, HY; Ng, KKH; Nguyen, PHB; Pease, NA; Vaughan, JC; Woodworth, MA | 1 |
| Davidovich, C; Zhang, Q | 1 |
| Dong, J; Jacob, Y; Joly, V; LeBlanc, C; Mendez, J; Mermaz, B; Poulet, A; Villarino, G; Voigt, P; Webb, KM | 1 |
| Coradin, M; Garcia, BA; Janssen, KA; Lu, C; Sidoli, S | 1 |
| Diaz, K; Huang, R; Meng, Y | 1 |
| Engelberg, IA; Foley, CA; Frye, SV; James, LI | 1 |
| Cao, D; Ding, H; Hou, J; Huang, B; Lin, C; Liu, J; Liu, L; Liu, X; Liu, Y; Lu, J; Wang, G; Zhang, N; Zhang, X; Zhang, Y | 1 |
| Debnath, A; Hardy, DB; Holloway, AC; Raez-Villanueva, S | 1 |
| Berthelet, J; Calegari-Silva, T; Cheeseman, K; Hamroune, J; Jannot, G; Letourneur, F; Lourenço, N; Rodrigues-Lima, F; Villares, M; Weitzman, JB | 1 |
| Davidovich, C; Uckelmann, M | 1 |
| Azarcon, P; Bia, R; Davis, K; Franklin, S; Hickenlooper, S; Horiuchi, E; Szulik, MW | 1 |
| Fisher, RP; Pagé, V; Pinto, D; Tanny, JC | 1 |
| Ban, T; Chen, L; Du, J; Duan, CG; Guo, Z; Kim, C; Lang, Z; Niu, Q; Song, Z; Tang, K; Wang, L; Zhang, H; Zhu, JK | 1 |
| Anguera, MC; Buckner, JH; Cancro, MP; Knox, JJ; Paneru, B; Posso, S; Pyfrom, S | 1 |
| Altmann, S; Bäurle, I; Brzezinka, K; Friedrich, T; Gorka, M; Graf, A; Kappel, C; Lämke, J; Oberkofler, V; Skirycz, A; Sokolowska, E; Trindade, I | 1 |
| Hintzen, JCJ; Jian, J; Luo, Y; Mecinović, J; Porzberg, MRB; Proietti, G; White, PB | 1 |
| Aoki, F; Funaya, S; Kawamura, M; Sugie, K; Suzuki, MG | 1 |
| Burke, TP; Engström, P; Iavarone, AT; Tran, CJ; Welch, MD | 1 |
| Iida, H; Iwamori, N; Iwamori, T; Kaneko, T; Wang, Y | 1 |
| Chen, X; Cheng, P; Feng, X; Guang, S; Huang, X; Weng, C; Xu, Z; Zeng, C; Zhu, C | 1 |
| Crowley, PB; Frizzell, L; Lowndes, NF; Luessing, J; Maretto, S; Ramberg, KO; Sakhteh, M; Sarai, N; Tsanov, N | 1 |
| Bichmann, M; Ehrnhoefer, DE; Ercan-Herbst, E; Gasparini, L; Gomez Ramos, B; Haberkant, P; Hu, C; Jin, L; Neu, M; Prat Oriol, N; Ried, JS; Schlüter, A; Schöndorf, DC; Schwärzler, V; Tian, Y; Wang, X | 1 |
| An, JY; Bak, MS; Chae, YC; Chun, YS; Kim, A; Kim, SJ; Kim, Y; Kim, YG; Kim, YL; Lee, YS; Seo, SB | 1 |
| Separovich, RJ; Wilkins, MR | 1 |
| Bao, L; Chen, J; Diao, L; Feng, W; Li, M; Pan, X; Wang, S; Xie, X; Zhang, X; Zou, W | 1 |
| Baughn, LB; Duan, Z; Gupta, V; MacCarthy, T; Scharff, MD; Wang, X; Yu, G; Zhang, Y | 1 |
| Anderson, KC; Durbin, AD; Gryder, BE; Hideshima, T; Hino, S; Johansson, C; Kawano, Y; Khan, J; Kim, Y; Kurata, K; Lauberth, S; Li, D; Masuda, T; Matsuoka, M; Minami, T; Munshi, NC; Nakao, M; Ogiya, D; Ohguchi, H; Ohtsuki, S; Oppermann, U; Park, PMC; Pei, C; Qi, J; Samur, MK; Tai, YT; Usuki, S; Wang, T; Wimalasena, VK; Zhang, X | 1 |
| Andrieux, A; Sadoul, K | 1 |
| Dong, A; Liu, Y; Loppnau, P; Min, J; Yan, X; Yang, Y; Zhang, M; Zhou, M | 1 |
| Engist, B; Erikson, G; Genoud, C; Jenuwein, T; Meyer, AG; Mittler, G; Montavon, T; Musa, Y; Onishi-Seebacher, M; Ryan, D; Shukeir, N | 1 |
| Lan, HC; Lin, YR; Liu, YY; Shen, CC; Yang, WM; Yao, YL | 1 |
| Ahmad, K; Henikoff, S | 1 |
| Shi, X; Wen, H; Yu, Y | 1 |
| Huang, P; Li, W; Lin, L; Peng, Y; Xu, J; Yan, Y; Ye, H; Zhang, H; Zhang, R; Zheng, Z | 1 |
| Cao, X; Chai, Y; Ding, Y; Hu, Y; Shen, Z; Song, J; Wang, B; Wang, C; Wang, X; Wu, J; Xu, J; Xu, X; Zhao, Y | 1 |
| Arita, K; Funyu, T; Kanemaru, Y; Onoda, H | 1 |
| Gao, F; Li, D; Qin, Y; Xu, L; Xu, W; Yang, Y; Yu, X; Zhao, S | 1 |
| Anderson, J; Cantilena, S; de Boer, J; Hargrave, D; Meier, S; Michod, D; Niklison Chirou, MV; Salomoni, P | 1 |
| Chen, L; Deng, X; Gao, F; Li, B; Li, L; Li, X; Liang, T; Pan, Y; Ren, Y; Wang, J; Yang, D; Yang, Y; Zhai, S; Zhang, S; Zhang, X; Zhao, J; Zheng, Y; Zhou, P | 1 |
| Barnash, KD; Budziszewski, GR; Chiarella, AM; Cholensky, SH; Clinkscales, SE; Hathaway, NA; Herring, LE; James, LI; McGinty, RK; Norris-Drouin, JL; Pearce, KH; Rectenwald, JM; Waybright, JM | 1 |
| Chen, Q; Einarsson, H; Ekwall, K; Frederiksen, KS; Lerdrup, M; Liu, CF; Nair, N; Nordenskiöld, L; Prasanna, C; Shi, X; Shoaib, M; Svensson, JP; Sørensen, CS; Walter, D; Yang, R | 1 |
| Goda, T; Honma, K; Machida, C; Mochizuki, K | 1 |
| Adroub, S; Della Valle, F; El Said, NH; Gimenez, J; Liu, P; Orlando, V; Paytuví-Gallart, A | 1 |
| Hamada, Y; Inada, E; Iseki, M; Katsuda, Y; Kondo, T; Kuzumaki, N; Matsufuji, M; Mori, T; Narita, M; Sato, D; Takeshima, H; Tanaka, K; Ushijima, T; Yamabe, Y; Yamaguchi, K | 1 |
| Gou, Y; Han, C; Lin, S; Ning, W; Tan, X; Wang, C; Xue, Y; Zhang, C; Zhang, W | 1 |
| Barral, A; Bartusel, M; Benson, L; Bleckwehl, T; Clark, SJ; Crispatzu, G; Dorighi, KM; Laugsch, M; Manzanares, M; Rada-Iglesias, Á; Reik, W; Respuela, P; Schaaf, K; van IJcken, WFJ; Wysocka, J | 1 |
| Bilmez, Y; Ozturk, S; Talibova, G | 1 |
| Dokholyan, NV; Kutateladze, TG; Vann, KR; Vishweshwaraiah, YL | 1 |
| Acheampong, A; Chen, Z; Huang, Q; Li, L | 1 |
| Ji, T; Liu, A; Mao, X; Weng, Y | 1 |
| Bu, G; Chen, L; Chen, ZX; Dou, C; He, H; Li, Z; Liu, X; Liu, Z; Miao, YL; Wang, T; Wu, D; Xu, T; Yin, S; Yu, L; Zhang, J; Zhang, X; Zhou, J; Zhu, W | 1 |
| Bayer, P; Hof, F; Isaacs, L; Kamba, BE; Le, MH; Schrader, T; Warmerdam, Z | 1 |
| Baabe, D; Bröring, M; Burghaus, O; Gutsmann, T; Hurwitz, R; Kolbe, M; Nehls, C; Wang, C | 1 |
| Baldensperger, T; Dau, T; Di Sanzo, S; Glomb, MA; Heller, R; Henning, C; Kirkpatrick, JM; Leheis, A; Marx, C; Ori, A; Parca, L; Rändler, TL; Spengler, K; Wang, ZQ | 1 |
| Fahrenkrog, B; Vaz, M | 1 |
| Chen, L; Jiang, W; Zheng, S | 1 |
| Adriaenssens, E; Angrand, PO; Cicero, J; Hasanpour, S; Le Bourhis, X; Raby, L; Toillon, RA; Van Seuningen, I; Völkel, P | 1 |
| Lee, JM; Park, SC | 1 |
| Gao, L; Li, Q; Song, P; Yu, W | 1 |
| Li, L; Ma, C; Zhao, J; Zou, G; Zou, Y | 1 |
| Gocek, N; Laskowski, T; Polit, JT; Szczeblewski, P; Winnicki, K; Żabka, A | 1 |
| Iimura, T; Ikedo, A; Imai, Y; Inoue, K; Lee, JW; Xia, Y | 1 |
| Chen, ES; Lam, UTF | 1 |
| Diao, H; Hao, N; Koropatnick, J; Liu, Q; Maleki Vareki, S; Min, J; Min, W; Raphael, J; Sang, Y; Wang, Z; Xiong, J; Xu, D; Zhang, Y; Zheng, X | 1 |
| Garcia, BA; Kori, Y; Lund, PJ; Noh, KM; Sidoli, S; Trovato, M; Yuan, ZF | 1 |
| Li, F; Liu, Y; Min, J; Qin, S; Wei, Z; Yan, X; Yang, X; Yang, Y; Zhang, M; Zhou, M | 1 |
| Geil, CN; Lee, TH; Li, D; McGinty, RK; Smith, CB; Spangler, CJ; Wang, GG; Yadav, SP | 1 |
| Luco, RF; Núñez-Álvarez, Y; Oldfield, AJ; Segelle, A; Voigt, P; Webb, KM | 1 |
| Aljazi, MB; Gao, Y; He, J; Wu, Y | 1 |
| Amatori, S; Auber, LA; Cantatore, F; Casciaro, F; Fanelli, M; Giorgio, M; Perna, A; Persico, G; Rusin, M | 1 |
| Didonna, A; Ma, Q; Matsunaga, A; Mofrad, MRK; Shams, H | 1 |
| Abbasi, Y; Anbiyaee, O; Farzaneh, M; Ghaedrahmati, F; Gholami, E; Kuchaki, Z; Meybodi, SM; Rashid Sheykhahmad, F | 1 |
| Alarcon, EI; Arvanitis-Vigneault, A; Brunzelle, JS; Couture, JF; Davarinejad, H; Dong, J; Huang, YC; Jacob, Y; Joly, V; LeBlanc, C; Mermaz, B; Muñoz, M; Poulet, A; Ross, A; Rotstein, BH; Thomson, G; Valsakumar, D; Villarino, G; Voigt, P | 1 |
| Biggar, KK; Chopra, A; Hoekstra, M; Willmore, WG | 1 |
| Baudre, L; Baulande, S; Bento, ST; Bohec, M; Dahmani, A; Durand, A; Eisele, A; Foulon, S; Grosselin, K; Landragin, C; Letouzé, E; Lyne, AM; Marangoni, E; Marsolier, J; Perié, L; Prompsy, P; Salomon, AV; Sourd, L; Trouchet, A; Vallot, C | 1 |
| Magnuson, T; Menon, DU; Mu, W; Murcia, NS; Smith, KN; Yee, D | 1 |
| Deng, H; Guo, H; Qian, P; Rahman, A; Xu, XL; Zhao, YY | 1 |
| Chen, X; Deng, H; Jia, S; Liao, Q; Liu, X; Ouyang, G; Sun, X; Tang, J; Wang, Z; Xiao, W; Zha, H; Zhu, C | 1 |
| Huang, L; Long, H; Shi, L; Song, A; Zhou, Z | 1 |
| Gabellini, D; Pedrotti, S | 1 |
| Boettiger, AN; Cech, TR; Chang, HY; Corces, MR; Granja, JM; Kraft, K; Long, Y; Magg, A; Mundlos, S; Murphy, SE; Wittler, L; Yost, KE | 1 |
| Kawano, F; Shimizu, J | 1 |
| Bonasio, R; Scacchetti, A | 1 |
| Al Ojaimi, M; Almannai, M; Banimortada, BJ; El-Hattab, AW; Othman, A; Riedhammer, KM | 1 |
| Erlendson, AA; Freitag, M | 1 |
| Jeltsch, A; Weirich, S | 2 |
| Barghout, SH; Barsyte-Lovejoy, D; Machado, RAC | 1 |
| Bloskie, T; Storey, KB | 1 |
| Ali, SD; Chong, KT; Tayara, H | 1 |
| Cao, YC; Duan, JY; Guo, B; Lei, LM; Li, CC; Li, FX; Liao, XB; Lin, X; Ou-Yang, WL; Shan, SK; Tang, KX; Ullah, MHE; Wang, Y; Wu, F; Wu, YY; Xu, F; Xu, QS; Yuan, LQ; Zheng, MH; Zhou, ZA | 1 |
| Diao, W; Li, Y; Wang, J; Xu, S; Zheng, J | 1 |
| Hua, J; Li, N; Peng, S; Shen, Q; Wu, X; Yang, F; Yu, S; Zhang, J; Zhang, R; Zhang, S; Zhao, W | 1 |
| Azorín, F; Bernués, J; Bonet-Costa, C; Castejón, L; Climent-Cantó, P; Fernández-Castañer, E; Guerrero-Pepinosa, N; Izquierdo-Boulstridge, A; Leal, N; Reina, O; Vujatovic, O | 1 |
| Caswell, SJ; Clarkson, PN; Edwardes, LV; Giurrandino, M; Gohlke, A; Hamm, GR; Jervis, KV; Kostomiris, DH; Pflug, A; Pollard, HK; Syson, K; Zhai, X | 1 |
| Balasubramaniam, M; Burge, N; Christensen, D; Cox, K; Craigie, R; Dash, C; Kvaratskhelia, M; Li, M; Linderberger, J; Pandhare, J; Poirier, MG; Prakash, P; Sapp, N; Thapa, S | 1 |
| Benamrouz-Vanneste, S; Certad, G; Chabe, M; Creusy, C; Duval, E; Even, G; Gantois, N; Guyot, K; Meloni, D; Sawant, M; Viscogliosi, E; Weitzman, JB; Wintjens, R | 1 |
| Lou, K; Xu, X; Xu, Y; Zhang, Y; Zheng, B | 1 |
| Han, B; Liang, C; Wang, JL; Xie, RJ; Yang, Q; Zhang, JY; Zhang, YW | 1 |
| Chen, D; Chen, X; Feng, X; Guang, S; Hong, M; Hou, X; Huang, M; Zhu, C | 1 |
| Blanco-Esperguez, K; Kästner, J; Mendizábal, F; Miranda-Rojas, S; Tuñón, I | 1 |
| Khandelwal, M; Kumar Rout, R; Li, A; Mallik, S; Umer, S | 1 |
| Guo, P; Hoang, N; Rajawasam, K; Sanchez, J; Sun, H; Trinidad, K; Zhang, EH; Zhang, H | 1 |
| Baubec, T; Chen, C; Gu, J; Krone, MW; Martyn, GD; Pearce, KH; Sidhu, SS; Tang, JQ; Veggiani, G; Villaseñor, R; Waters, ML | 1 |
| Chin, HG; Estève, PO; Pradhan, S; Ruse, C; Sen, S; Vishnu, US | 1 |
| Ding, X; Duan, X; Jiang, G; Jiang, Y; Liang, H; Liu, X; Song, L; Sun, J; Xiao, L | 1 |
| Deng, H; Guo, H; Ma, Y; Qian, P; Rahman, A; Shaik, F; Wang, CM; Wang, KN; Xu, XL; Zhao, YY | 1 |
| Bedford, MT; Chen, Q; Cheng, X; Horton, JR; Zhang, X; Zhou, J | 1 |
| Pearson, JT | 1 |
| Berryhill, CA; Cordeiro-Spinetti, E; Cornett, EM; Dickson, BM; Doud, EH; Hanquier, JN; Mosley, AL; Rothbart, SB | 1 |
| Li, Z; Wang, J; Wang, Y; Zhang, Y | 1 |
| Heinemann, U; Panáková, D; Petrović, S; Phan, MHQ; Rami, B; Roske, Y | 1 |
| Berr, A; Carles, CC; Chabouté, ME; Faigenboim, A; Fal, K; Ishkhneli, N; Le Masson, M; Moyal, NL; Pano, E; Tomkova, D; Villette, C; Williams, LE | 1 |
| Bao, X; Dang, S; Jing, Y; Lam, WH; Li, XD; Lin, J; Liu, Z; Tian, G; Wong, JWH; Wu, Y; Yang, E; Yu, D; Zhai, Y | 1 |
| Bonaldi, T; Cuomo, A; Ehrenhofer-Murray, AE; Kshirsagar, R; Munhoven, A; Samel-Pommerencke, A; Tran Nguyen, TM | 1 |
| Cho, JY; Kim, JH; Sutopo, NC | 1 |
| Alkafri, N; Bissardon, C; Bohic, S; Charlet, L; Conlan, RS; Francis, LW; Gazze, S; Gonzalez, D; Gourlan, AT; James, DW; Knodel, F; Proux, O; Quintela, M; Rathert, P; Toubhans, B | 1 |
| Cai, X; Dong, A; Su, W; Wang, F; Wei, H; Zhang, L | 1 |
| An, M; Hoffman, BG; Luciani, DS; Lynn, FC; Maeshima, N; McDonald, CL; Pasula, DJ; Suresh, P; Vanderkruk, B | 1 |
| Fujimori, DG; Kutateladze, TG; Ortiz, G | 1 |
| Berryhill, CA; Cornett, EM; Hanquier, JN; Hudmon, A; Sahoo, FK; Sanders, K; Vilseck, JZ | 1 |
| Bengtsen, M; Davydova, E; Falnes, PØ; Herrera, MC; Małecki, JM | 1 |
| Cai, R; Chen, Y; Ge, K; Li, T; Li, Y | 1 |
| Angulo Ibanez, M; Cho, J; Chua, K; Francis, JW; Gozani, O; Hausmann, S; Jeong, J; Liu, S; Mazur, PK; Mealey-Farr, R; Park, J | 1 |
| Cao, Y; Chang, Y; Li, M; Li, Z; Qing, G; Xiong, Y; Zhao, X | 1 |
| Bashtrykov, P; Bröhm, A; Bui, T; Jeltsch, A; Khella, MS; Pleiss, J; Schnee, P; Weirich, S | 1 |
| Larsson, J; Lindehell, H; Schwartz, YB | 1 |
| Dohmae, N; Fukuda, K; Hiratani, I; Ikeda, K; Inoue, A; Kimura, H; Miura, H; Okada, Y; Okayama, S; Ono, T; Onoue, K; Shimi, T; Shimura, C; Shinkai, Y; Suzuki, T; Yonemura, S | 1 |
| Francis, JW; Gozani, O; Lu, J; Narkhede, P; Shao, Z; Song, J; Trinh, AT | 1 |
| Batbayar, G; Horike, SI; Ishimura, A; Lyu, H; Meguro-Horike, M; Suzuki, T; Takino, T; Terashima, M; Wanna-Udom, S | 1 |
| Li, X; Li, XD; Liu, S | 1 |
| Chen, Y; Gao, L; He, Y; Kong, X; Li, G; Li, Q; Li, Y; Liu, Y; Long, Q; Pu, P; Tong, S; Yang, Y; Zhang, J | 1 |
| Deng, C; Lian, J; Liu, X; Su, Y | 1 |
| Bai, R; Deng, J; Han, B; Li, Q; Sun, Q; Xin, T; Zhang, Y; Zhuang, Z | 1 |
| Dalpatraj, N; Naik, A; Thakur, N | 1 |
| Gan, XL; Guan, JX; Ren, YX; Ren, ZF; Tang, LY; Wang, B; Weng, ZJ; Yang, YZ; Zhang, XF; Zhou, M | 1 |
| Gao, Z; Hu, R; Li, M; Li, Y; Liu, C; Mei, M; Pang, B; Ren, Y; Wang, Y; Yang, J; Zhang, B; Zhang, X; Zhou, X | 1 |
| Brown, MA; Mayfield, RD; Nie, H; Sims, RJ; Tiwari, GR; Tucker, HO; Zhu, L | 1 |
| Guan, H; Lei, J; Li, B; Li, H; Ou, Y; Peng, B; Ruan, C; Wang, P; Yan, C; Zhang, P; Zheng, X | 1 |
| Guo, DL; Liu, HN; Pei, MS; Wei, TL | 1 |
| Fraser, OA; Namitz, KEW; Showalter, SA | 1 |
| Baek, SH; Kim, D; Nam, HJ | 1 |
| Fan, GF; Li, XJ; Li, YJ; Liu, J; Liu, RP; Qu, JR; Sun, R; Wu, JZ; Xue, XY; Zheng, Q; Zhou, F | 1 |
| Feng, X; Li, G; Liang, H; Luo, R; Song, Y; Tong, B; Wang, B; Wang, K; Wu, D; Yang, C; Zhang, W; Zhou, X; Zhu, D | 1 |
| Benton, ML; Davies, JP; Han, D; Nordman, JT; Plate, L; Schaffner, SH | 1 |
| Bhanu, NV; Bleichert, F; Connor, LJ; Ekundayo, BE; Garcia, BA; King, MC; Lu-Culligan, WJ; Machyna, M; Pintado-Urbanc, AP; Rose, BT; Simon, MD; Vock, IW; Xie, Y; Zimmer, JT | 1 |
| Afenjar, A; Banka, S; Barish, S; Bellen, HJ; Blyth, M; Choufani, S; Costain, G; Cytrynbaum, C; Deshwar, AR; Haldeman-Englert, C; Hayes, I; Haynes, D; Huang, Y; Jobling, R; Kanca, O; Keren, B; Le Quesne Stabej, P; Mao, X; Mignot, C; Nil, Z; Prescott, T; Robin-Renaldo, F; Shinawi, M; Sisco, K; Tveten, K; Vøllo, A; Wangler, MF; Wegner, DJ; Weksberg, R; Wheeler, PG; Wilson, C; Yamamoto, S; Yap, P; Zhang, X; Zon, J | 1 |
| Gu, R; Janknecht, R; Kim, TD; Oh, S; Shin, S; Song, H; Sui, Y | 1 |
| Burkholder, NT; Byrum, SD; Cai, L; Diao, Y; Edmondson, RD; Fan, H; Gong, W; Guo, Y; Kanchi, KL; Kim, A; Kuhlers, PC; Lu, J; Mackintosh, SG; Pan, B; Raab, JR; Song, J; Storey, AJ; Strahl, BD; Sun, T; Tackett, AJ; Wang, GG; Xu, C; Zhao, S | 1 |
| Duan, S; Goff, SP; Hua, X; Li, Y; Li, Z; Lu, C; Menolfi, D; Xu, X; Zha, S; Zhang, Z; Zhou, H | 1 |
| Cordeiro-Spinetti, E; Rothbart, SB | 1 |
221 review(s) available for lysine and isomethyleugenol
| Article | Year |
|---|---|
Biological significance of methylated derivatives of lysine and arginine.
Topics: Animals; Arginine; Blood Pressure; Cell Division; Cytochrome c Group; Histones; Lysine; Methylation; Muscle Proteins; Neoplasms, Experimental; Proteins; Structure-Activity Relationship | 1977 |
Mapping of contact areas in protein-nucleic acid and protein-protein complexes by differential chemical modification.
Topics: Acetylation; Amino Acids; Amino Acyl-tRNA Synthetases; Binding Sites; Chemical Phenomena; Chemistry; Cytochrome c Group; Electron Transport Complex IV; Isotope Labeling; Lysine; Macromolecular Substances; Methylation; Molecular Conformation; Nucleic Acids; Oxidation-Reduction; Protein Denaturation; Proteins; Purines; RNA, Transfer; Structure-Activity Relationship | 1979 |
RNA fractionation on Kieselguhr columns.
Topics: Amphibians; Animals; Arginine; Birds; Chromatography; Histones; Insecta; Lysine; Mammals; Methylation; Ornithine; Peptides; Plants; Polynucleotides; Protamines; RNA; RNA, Bacterial; RNA, Messenger; RNA, Ribosomal; RNA, Transfer; RNA, Viral; Saccharomyces; Sea Urchins; Serum Albumin; Serum Albumin, Bovine; Silicon Dioxide | 1972 |
Chromosomal proteins.
Topics: Acetylation; Amino Acid Sequence; Animals; Arginine; Chromatin; Chromosomes; DNA; Electrophoresis, Polyacrylamide Gel; Histones; Hormones; Lysine; Magnetic Resonance Spectroscopy; Methylation; Nucleoproteins; Oxidative Phosphorylation; Protein Binding; RNA; Species Specificity; Transcription, Genetic | 1974 |
Histones: structure and function.
Topics: Acetates; Acylation; Amino Acid Sequence; Animals; Arginine; Cattle; Chemical Phenomena; Chemistry; Chromatin; Cysteine; Cystine; DNA; Female; Histidine; Histones; Lysine; Male; Methylation; Molecular Weight; Oxidation-Reduction; Phosphoproteins; Phosphoric Acids; Protein Binding; Protein Conformation; RNA; Serine; Thymus Gland | 1971 |
Histone methylation versus histone acetylation: new insights into epigenetic regulation.
Topics: Acetylation; Animals; Chromobox Protein Homolog 5; Chromosomal Proteins, Non-Histone; DNA Methylation; Gene Expression Regulation, Developmental; Gene Silencing; Heterochromatin; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Methyltransferases; Neoplasms; Protein Methyltransferases; Transcription, Genetic | 2001 |
The many faces of histone lysine methylation.
Topics: Animals; Chromatin; DNA Methylation; Gene Silencing; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Models, Genetic; RNA; X Chromosome | 2002 |
Histone methylation: dynamic or static?
Topics: Amino Acid Sequence; Animals; Arginine; Gene Expression Regulation; Histones; Lysine; Methylation; Molecular Sequence Data | 2002 |
Structure of SET domain proteins: a new twist on histone methylation.
Topics: Amino Acid Sequence; Animals; Binding Sites; Coenzymes; Conserved Sequence; Histones; Humans; Lysine; Methylation; Methyltransferases; Models, Molecular; Molecular Sequence Data; Protein Structure, Secondary; Protein Structure, Tertiary; Sequence Alignment; Substrate Specificity | 2003 |
Preparation of DNA-protein complexes suitable for spectroscopic analysis.
Topics: Aldehydes; Cross-Linking Reagents; DNA; DNA-Binding Proteins; Electrophoretic Mobility Shift Assay; Guanine; Lysine; Macromolecular Substances; Methylation; Models, Molecular; Nuclear Magnetic Resonance, Biomolecular; Nucleoproteins; Oxidation-Reduction; Photochemistry; Plant Proteins; Protein Conformation; Ribosome Inactivating Proteins, Type 2; Schiff Bases; Spectrometry, Fluorescence | 2003 |
Memorable transcription.
Topics: DNA Polymerase III; DNA-Binding Proteins; Gene Expression Regulation, Fungal; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Methyltransferases; Protein Methyltransferases; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Transcription Factors; Transcriptional Activation | 2003 |
An epigenetic road map for histone lysine methylation.
Topics: Animals; Epigenesis, Genetic; Histones; Lysine; Methylation | 2003 |
Transcriptional elongation by RNA polymerase II and histone methylation.
Topics: Animals; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Methyltransferases; Models, Biological; Protein Methyltransferases; RNA Polymerase II; RNA, Messenger; Transcription, Genetic; Transcriptional Elongation Factors | 2003 |
Cracking the histone code: one, two, three methyls, you're out!
Topics: Amino Acid Sequence; Animals; Catalytic Domain; Cell Nucleus; Eukaryotic Cells; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Macromolecular Substances; Methylation; Methyltransferases; Protein Methyltransferases | 2003 |
Histone lysine methylation: a signature for chromatin function.
Topics: Animals; Chromatin; Dosage Compensation, Genetic; Heterochromatin; Histones; Humans; Lysine; Methylation; Protein Methyltransferases; Protein Processing, Post-Translational; Protein Structure, Tertiary; X Chromosome | 2003 |
Generation and characterization of methyl-lysine histone antibodies.
Topics: Amino Acid Sequence; Animals; Antibodies; Enzyme-Linked Immunosorbent Assay; Fluorescent Antibody Technique; Heterochromatin; Histone-Lysine N-Methyltransferase; Histones; Immunoblotting; Lysine; Methylation; Mice; Quality Control; Rabbits | 2004 |
Tips in analyzing antibodies directed against specific histone tail modifications.
Topics: Amino Acid Sequence; Animals; Antibodies; Antibody Specificity; Blotting, Western; Enzyme-Linked Immunosorbent Assay; Fluorescent Antibody Technique; Histones; Humans; Immunoblotting; Lysine; Male; Methylation; Mice; Molecular Sequence Data | 2004 |
Histone methylation: recognizing the methyl mark.
Topics: Animals; Antibody Affinity; Antibody Specificity; Arginine; Blotting, Western; Chromatin; Enzyme-Linked Immunosorbent Assay; Fluorescent Antibody Technique; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Molecular Structure; Peptides; Polymerase Chain Reaction; Precipitin Tests; Protein Methyltransferases; Rabbits; Scintillation Counting | 2004 |
The indexing potential of histone lysine methylation.
Topics: Animals; Gene Silencing; Heterochromatin; Histones; Lysine; Mammals; Methylation; Methyltransferases; Polycomb-Group Proteins; Repressor Proteins | 2004 |
The functions of E(Z)/EZH2-mediated methylation of lysine 27 in histone H3.
Topics: Animals; Dosage Compensation, Genetic; Drosophila; Drosophila Proteins; Gene Expression Regulation; Gene Silencing; Histone-Lysine N-Methyltransferase; Histones; Homeodomain Proteins; Lysine; Methylation; Nuclear Proteins; Polycomb Repressive Complex 1; Polycomb Repressive Complex 2; Repressor Proteins | 2004 |
Structure and function of histone methyltransferases.
Topics: Animals; Arginine; Drosophila; Heterochromatin; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Humans; Lysine; Methylation; Models, Molecular; Phosphorylation; Protein Methyltransferases; Saccharomyces cerevisiae; Substrate Specificity | 2004 |
Role of protein methylation in regulation of transcription.
Topics: Amino Acid Sequence; Animals; Arginine; Chromatin; Histones; Humans; Lysine; Methylation; Molecular Sequence Data; Protein Methyltransferases; Transcription, Genetic | 2005 |
A crack in histone lysine methylation.
Topics: Epigenesis, Genetic; Gene Silencing; Histones; Lysine; Methylation; Oxidoreductases, N-Demethylating | 2004 |
[On the research of histone methylation].
Topics: Acetylation; Animals; DNA Methylation; Euchromatin; Gene Expression Regulation; Heterochromatin; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Phosphorylation; Protein Methyltransferases | 2004 |
Epigenetic regulation by histone methylation and histone variants.
Topics: Amino Acid Sequence; Animals; Chromatin; Chromosomes; Epigenesis, Genetic; Gene Expression Regulation; Gene Silencing; Heterochromatin; Histones; Humans; Lysine; Methylation; Molecular Sequence Data; Nucleosomes; Protein Processing, Post-Translational; Protein Structure, Tertiary | 2005 |
Structural and sequence motifs of protein (histone) methylation enzymes.
Topics: Amino Acid Motifs; Amino Acid Sequence; Animals; Arginine; Binding Sites; Chromatin; Crystallography, X-Ray; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Mass Spectrometry; Methylation; Models, Molecular; Molecular Sequence Data; Peptides; Phenylalanine; Protein Binding; Protein Structure, Tertiary; Proteins; Protons; Sequence Homology, Amino Acid; Tyrosine; Zinc | 2005 |
An epigenetic code for DNA damage repair pathways?
Topics: Adenosine Diphosphate Ribose; Animals; Chromatin; Chromatin Immunoprecipitation; DNA; DNA Damage; DNA Repair; DNA Replication; Fungal Proteins; Histones; Humans; Lysine; Macromolecular Substances; Mass Spectrometry; Methylation; Phosphorylation; Recombination, Genetic; Ribose | 2005 |
Effector proteins for methylated histones: an expanding family.
Topics: Carrier Proteins; Chromobox Protein Homolog 5; Chromosomal Proteins, Non-Histone; DNA Helicases; DNA-Binding Proteins; Histones; Humans; Lysine; Membrane Proteins; Methylation | 2005 |
Chromatin and the DNA damage response.
Topics: Cell Cycle Proteins; Chromatin; Chromatin Assembly and Disassembly; DNA Damage; DNA Repair; Histones; Humans; Intracellular Signaling Peptides and Proteins; Lysine; Methylation; Phosphoproteins; Telomere; Yeasts | 2005 |
Cross-talking histones: implications for the regulation of gene expression and DNA repair.
Topics: DNA Repair; Gene Expression Regulation; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins | 2005 |
Steps toward understanding the inheritance of repressive methyl-lysine marks in histones.
Topics: Amino Acid Sequence; Animals; Drosophila; Drosophila Proteins; Epigenesis, Genetic; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Male; Methylation; Mice; Nuclear Proteins; Polycomb Repressive Complex 2; Prostatic Neoplasms; Protein Methyltransferases; Repressor Proteins; Sequence Homology, Amino Acid | 2004 |
Reversing histone methylation.
Topics: Animals; Arginine; Chromatin; Histones; Humans; Lysine; Methylation | 2005 |
Maintenance of open DNA base pairs through histone acetylated lysine-purine interaction leading to transcriptional activation: a proposed mechanism.
Topics: Acetylation; Base Pairing; DNA; Histones; Lysine; Methylation; Protein Processing, Post-Translational; Purines; Transcriptional Activation | 2005 |
RNAi-directed assembly of heterochromatin in fission yeast.
Topics: Animals; Chromatin; Genome; Heterochromatin; Histone Deacetylases; Histones; Lysine; Methylation; Models, Biological; Models, Genetic; RNA; RNA Interference; RNA Polymerase II; RNA-Dependent RNA Polymerase; RNA, Double-Stranded; RNA, Small Interfering; Schizosaccharomyces | 2005 |
The diverse functions of histone lysine methylation.
Topics: Animals; Gene Silencing; Heterochromatin; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Transcription, Genetic; Transcriptional Activation | 2005 |
Lysine methylation and 'signaling memory'.
Topics: Animals; Cell Nucleus; Cytosol; Humans; Immunologic Memory; Lysine; Methylation; Models, Immunological; Signal Transduction | 2006 |
Chromatin modifications by methylation and ubiquitination: implications in the regulation of gene expression.
Topics: Amino Acid Sequence; Animals; Chromatin; Gene Expression Regulation; Gene Silencing; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Methyltransferases; Models, Molecular; Molecular Sequence Data; Myeloid-Lymphoid Leukemia Protein; Polycomb-Group Proteins; Protein Processing, Post-Translational; Repressor Proteins; RNA Interference; Saccharomyces cerevisiae Proteins; Ubiquitin; X Chromosome Inactivation | 2006 |
Lysine methylation goes global.
Topics: Animals; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Substrate Specificity; Tumor Suppressor Protein p53 | 2006 |
The control of histone lysine methylation in epigenetic regulation.
Topics: Animals; Chromatin Assembly and Disassembly; Epigenesis, Genetic; Histones; Humans; Lysine; Methylation; Methyltransferases; Models, Genetic; Transcription, Genetic | 2007 |
Histone H3 Lys 4 methylation: caught in a bind?
Topics: Adenosine Triphosphate; Animals; Chromatin; Histones; Humans; Lysine; Methylation; Models, Biological; Models, Chemical; Models, Genetic; Protein Binding; Protein Structure, Tertiary; Transcription, Genetic | 2006 |
Dynamic regulation of histone lysine methylation by demethylases.
Topics: Animals; Chromatin; Histones; Humans; Lysine; Methylation; Oxidoreductases, N-Demethylating; Protein Structure, Tertiary | 2007 |
Methylation of lysine 4 on histone H3: intricacy of writing and reading a single epigenetic mark.
Topics: Amino Acid Sequence; Animals; Epigenesis, Genetic; Genes, Developmental; Histones; Homeodomain Proteins; Humans; Lysine; Methylation; Molecular Sequence Data | 2007 |
Protein methylation and DNA repair.
Topics: Animals; Arginine; Chromatin; DNA; DNA Damage; DNA Repair; Histones; Humans; Lysine; Methylation; Models, Biological; Phosphorylation; Protein Processing, Post-Translational; Protein Structure, Tertiary; Proteins | 2007 |
Regulation of histone methylation by demethylimination and demethylation.
Topics: Animals; Arginine; Histones; Humans; Hydrolases; Lysine; Methylation; Oxidoreductases, N-Demethylating; Protein Processing, Post-Translational; Protein Structure, Tertiary; Protein-Arginine Deiminase Type 4; Protein-Arginine Deiminases | 2007 |
Structural dynamics of protein lysine methylation and demethylation.
Topics: Animals; Chromatin Assembly and Disassembly; Histones; Humans; Lysine; Methylation; Models, Chemical; Models, Molecular; Molecular Conformation; Protein Conformation; Protein Structure, Secondary; Protein Structure, Tertiary; Substrate Specificity | 2007 |
[Histone lysine methylation and epigenetics].
Topics: Animals; Cell Differentiation; Cell Division; DNA Methylation; Drosophila Proteins; Embryonic Development; Epigenesis, Genetic; Gene Expression Regulation, Developmental; Histones; Lysine; Methylation; Oxidoreductases, N-Demethylating; Polycomb Repressive Complex 1; RNA Interference; Transcription, Genetic | 2006 |
A methylation rendezvous: reader meets writers.
Topics: Acetylation; Chromatin; Chromobox Protein Homolog 5; Chromosomal Proteins, Non-Histone; Gene Silencing; Histones; Humans; Lysine; Methylation; Transcription, Genetic | 2007 |
[The roles of histone lysine methylation in epigenetic regulation].
Topics: Acetylation; Animals; DNA Methylation; Epigenesis, Genetic; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Protein Processing, Post-Translational; Transcription, Genetic | 2007 |
The function and regulation of the JARID1 family of histone H3 lysine 4 demethylases: the Myc connection.
Topics: Animals; Caenorhabditis elegans Proteins; Cell Transformation, Neoplastic; DNA-Binding Proteins; Drosophila melanogaster; Drosophila Proteins; Epigenesis, Genetic; Gene Expression Regulation; Histone Demethylases; Histone-Lysine N-Methyltransferase; Histones; Humans; Intracellular Signaling Peptides and Proteins; Jumonji Domain-Containing Histone Demethylases; Lysine; Mammals; Methylation; Mice; Mice, Knockout; Neoplasms; Nuclear Proteins; Nucleosomes; Oxidoreductases, N-Demethylating; Protein Processing, Post-Translational; Protein Structure, Tertiary; Proto-Oncogene Proteins c-myc; Repressor Proteins; Retinoblastoma-Binding Protein 2; Saccharomyces cerevisiae Proteins; Substrate Specificity; Tumor Suppressor Proteins | 2007 |
Histone H3K4 demethylases are essential in development and differentiation.
Topics: Animals; Cell Differentiation; Histones; Humans; Intracellular Signaling Peptides and Proteins; Lysine; Methylation; Protein Isoforms; Retinoblastoma Protein; Retinoblastoma-Binding Protein 2; Tumor Suppressor Proteins | 2007 |
Histone lysine demethylases: emerging roles in development, physiology and disease.
Topics: Amino Acid Sequence; Animals; Gene Expression Regulation, Developmental; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Molecular Sequence Data; Neoplasms; Nervous System Diseases | 2007 |
[Research progress on the relationship between nutrition and cancer epigenetics---histone modification mechanisms].
Topics: Acetylation; Biotinylation; DNA, Neoplasm; Epigenesis, Genetic; Histones; Humans; Lysine; Methylation; Neoplasms; Nutritional Physiological Phenomena; Phosphorylation; Poly Adenosine Diphosphate Ribose | 2007 |
Modular paths to 'decoding' and 'wiping' histone lysine methylation.
Topics: Amino Acid Sequence; Chromatin; Epigenesis, Genetic; Histones; Lysine; Methylation; Models, Molecular; Molecular Sequence Data; Protein Conformation | 2007 |
The emerging field of dynamic lysine methylation of non-histone proteins.
Topics: Animals; Histones; Humans; Lysine; Methylation; Proteins | 2008 |
Molecular implementation and physiological roles for histone H3 lysine 4 (H3K4) methylation.
Topics: Amino Acid Sequence; Animals; Chromatin; DNA-Binding Proteins; Epigenesis, Genetic; Gene Expression Regulation, Fungal; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Macromolecular Substances; Methylation; Protein Processing, Post-Translational; Saccharomyces cerevisiae Proteins; Transcription Factors | 2008 |
Controlling histone methylation via trans-histone pathways.
Topics: Chromatin; Histones; Lysine; Methylation; Protein Processing, Post-Translational; Saccharomyces cerevisiae; Ubiquitination | 2008 |
Epigenetic regulation in human brain-focus on histone lysine methylation.
Topics: Brain Chemistry; Gene Expression Regulation; Histones; Humans; Lysine; Mental Disorders; Methylation; RNA | 2009 |
Dynamic protein methylation in chromatin biology.
Topics: Animals; Arginine; Chromatin; DNA Damage; Embryonic Stem Cells; Epigenesis, Genetic; Gene Expression Regulation; Germ Cells; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Models, Molecular; Molecular Structure; Neoplasms; Oxidoreductases, N-Demethylating; Protein Conformation; Protein Methyltransferases; Protein Processing, Post-Translational; Tumor Suppressor Protein p53 | 2009 |
Epigenetics meets estrogen receptor: regulation of estrogen receptor by direct lysine methylation.
Topics: Epigenesis, Genetic; Estrogen Receptor alpha; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Humans; Lysine; Methylation | 2009 |
The multiple facets of histone H4-lysine 20 methylation.
Topics: Amino Acid Sequence; Animals; Gene Expression Regulation; Histones; Humans; Lysine; Methylation; Molecular Sequence Data | 2009 |
Characterization of human epigenomes.
Topics: Acetylation; Epigenesis, Genetic; Genomics; Histones; Humans; Lysine; Methylation; Models, Biological | 2009 |
Biochemical mechanisms of gene regulation by polycomb group protein complexes.
Topics: Animals; Chromatin; Gene Expression Regulation; Histones; Lysine; Methylation; Models, Biological; Polycomb-Group Proteins; Protein Binding; Repressor Proteins; Transcription, Genetic | 2009 |
Specificity of protein lysine methyltransferases and methods for detection of lysine methylation of non-histone proteins.
Topics: Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Protein Processing, Post-Translational; Proteins; Sensitivity and Specificity | 2008 |
Mechanisms of transcriptional repression by histone lysine methylation.
Topics: Animals; CpG Islands; Gene Expression Regulation; Histones; Humans; Lysine; Methylation; Models, Biological; Promoter Regions, Genetic; Transcription, Genetic | 2009 |
Histone lysine methylation in genomic imprinting.
Topics: Animals; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Methyltransferase 3A; Epigenesis, Genetic; Female; Genomic Imprinting; Germ Cells; Histones; Lysine; Male; Methylation; Mice; Models, Genetic; Repressor Proteins | 2009 |
Histone H3 lysine 4 di-methylation: a novel mark for transcriptional fidelity?
Topics: Acetylation; Animals; Histones; Humans; Lysine; Methylation; Promoter Regions, Genetic; Transcription, Genetic | 2009 |
SET7/9 mediated methylation of non-histone proteins in mammalian cells.
Topics: Animals; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; Epigenesis, Genetic; Gene Expression Regulation; Histone-Lysine N-Methyltransferase; Humans; Lysine; Mammals; Methylation; Mice; Models, Genetic; Proteasome Endopeptidase Complex | 2009 |
Histone H3 lysine 4 (H3K4) methylation in development and differentiation.
Topics: Animals; Cell Differentiation; Chromatin; Drosophila; Gene Expression Regulation, Developmental; Genes, Homeobox; Histones; Humans; Lysine; Methylation; Models, Biological; Nuclear Proteins | 2010 |
H3K27me1 is E(z) in animals, but not in plants.
Topics: Animals; Arabidopsis; Arabidopsis Proteins; Epigenesis, Genetic; Gene Silencing; Histones; Lysine; Methylation; Methyltransferases; Models, Genetic; Protein Structure, Tertiary | 2009 |
The future therapeutic potential of histone demethylases: A critical analysis.
Topics: Animals; Dealkylation; Drug Design; Drug Discovery; Enzyme Inhibitors; Epigenesis, Genetic; Histone Demethylases; Histone-Lysine N-Methyltransferase; Histones; Humans; Jumonji Domain-Containing Histone Demethylases; Lysine; Methylation; Protein Processing, Post-Translational; Protein Stability; Substrate Specificity; Transcription, Genetic | 2009 |
The emerging therapeutic potential of histone methyltransferase and demethylase inhibitors.
Topics: Arginine; Enzyme Inhibitors; Histone Demethylases; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Neoplasms; Protein Processing, Post-Translational | 2009 |
Histone modifications during DNA replication.
Topics: Acetylation; Animals; Chromatin; DNA Repair; DNA Replication; Epigenesis, Genetic; Histones; Humans; Lysine; Methylation; Phosphorylation; Protein Processing, Post-Translational; Transcription, Genetic | 2009 |
Promoting gene expression in plants by permissive histone lysine methylation.
Topics: Arabidopsis; Arabidopsis Proteins; Carotenoids; Chromatin; Epigenesis, Genetic; Flowers; Gene Expression Regulation, Plant; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Pollen | 2009 |
Structural basis for H3K4 trimethylation by yeast Set1/COMPASS.
Topics: Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Models, Molecular; Protein Conformation; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins | 2010 |
Coordinated chromatin control: structural and functional linkage of DNA and histone methylation.
Topics: Acetylation; Animals; Chromatin; DNA; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Epigenesis, Genetic; Histone Demethylases; Histones; Lysine; Methylation | 2010 |
Mixed lineage leukemia: a structure-function perspective of the MLL1 protein.
Topics: Amino Acid Motifs; Amino Acid Sequence; Binding Sites; Crystallography, X-Ray; Forecasting; Histone-Lysine N-Methyltransferase; Histones; Humans; Leukemia; Ligands; Lysine; Methylation; Models, Biological; Models, Molecular; Molecular Sequence Data; Myeloid-Lymphoid Leukemia Protein; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Structure-Activity Relationship | 2010 |
Mixed lineage leukemia: histone H3 lysine 4 methyltransferases from yeast to human.
Topics: Eukaryota; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Protein Processing, Post-Translational; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Schizosaccharomyces; Schizosaccharomyces pombe Proteins; Species Specificity | 2010 |
Epigenetic regulation of development by histone lysine methylation.
Topics: Animals; Epigenesis, Genetic; Gene Expression Regulation, Developmental; Histones; Humans; Lysine; Methylation; Methyltransferases; Mice; Models, Biological; Trans-Activators | 2010 |
Lysine methylation of nonhistone proteins is a way to regulate their stability and function.
Topics: Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Lysine; Methylation; Nuclear Proteins; Protein Stability; Ribosomal Proteins; Transcription Factors; Transcriptional Elongation Factors | 2010 |
[Research progress in modification of histone lysine methylation and congenital heart defect].
Topics: Epigenesis, Genetic; Heart Defects, Congenital; Histones; Humans; Lysine; Methylation | 2010 |
Decoding the histone H4 lysine 20 methylation mark.
Topics: Animals; DNA Replication; Histone Code; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Models, Biological; Protein Processing, Post-Translational; Transcription, Genetic | 2010 |
Reading, writing and editing methylated lysines on histone tails: new insights from recent structural studies.
Topics: Animals; Epistasis, Genetic; Histones; Humans; Jumonji Domain-Containing Histone Demethylases; Lysine; Methylation | 2010 |
Structural insights into histone lysine demethylation.
Topics: Animals; Epistasis, Genetic; Histone Demethylases; Histones; Humans; Jumonji Domain-Containing Histone Demethylases; Lysine; Methylation | 2010 |
Errors in erasure: links between histone lysine methylation removal and disease.
Topics: Animals; Cathepsin L; Cell Cycle Proteins; Histone Chaperones; Histone Demethylases; Histones; Humans; Lysine; Methylation; Neoplasms; Transcription Factors | 2011 |
Epigenetic mechanisms of mental retardation.
Topics: Acetylation; DNA Methylation; Epigenesis, Genetic; Histones; Humans; Intellectual Disability; Lysine; Methylation; Phosphorylation | 2011 |
Histone variants and modifications in plant gene regulation.
Topics: Cell Cycle Proteins; Chromatin; DNA-Directed RNA Polymerases; Epigenesis, Genetic; Gene Expression Regulation, Plant; Histone Code; Histones; Lysine; Methylation; Plant Proteins; Plants | 2011 |
Chatting histone modifications in mammals.
Topics: Acetylation; Animals; Arginine; Chromatin; Chromatin Assembly and Disassembly; Heterochromatin; Histone Code; Histones; Lysine; Mammals; Methylation; Protein Processing, Post-Translational; Ubiquitination | 2010 |
Structure and mechanisms of lysine methylation recognition by the chromodomain in gene transcription.
Topics: Amino Acid Sequence; Animals; Chromatin; Chromatin Assembly and Disassembly; Humans; Lysine; Methylation; Molecular Sequence Data; Protein Structure, Tertiary; Transcription, Genetic | 2011 |
Dynamics of histone H3 lysine 27 trimethylation in plant development.
Topics: Animals; Drosophila; Drosophila Proteins; Epigenesis, Genetic; Gene Expression Regulation, Developmental; Gene Expression Regulation, Plant; Gene Silencing; Genome, Plant; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Plant Development; Plants; Polycomb Repressive Complex 1; Polycomb-Group Proteins; Repressor Proteins | 2011 |
Role of histone modification on transcriptional regulation and HIV-1 gene expression: possible mechanisms of periodontal diseases in AIDS progression.
Topics: Acetylation; Acquired Immunodeficiency Syndrome; Butyric Acid; Chronic Periodontitis; Epigenesis, Genetic; Gene Expression Regulation, Viral; Histone Acetyltransferases; Histone Deacetylases; Histones; HIV-1; Humans; Lysine; Methylation; Peptide Chain Elongation, Translational; Porphyromonas gingivalis; Virus Activation; Virus Latency | 2011 |
Substrate and product specificities of SET domain methyltransferases.
Topics: Catalytic Domain; Enzyme Activation; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Myeloid-Lymphoid Leukemia Protein; NF-kappa B; Protein Interaction Mapping; Protein Structure, Tertiary; Structure-Activity Relationship; Substrate Specificity | 2011 |
Alterations in histone H4 lysine 20 methylation: implications for cancer detection and prevention.
Topics: Animals; Epigenesis, Genetic; Epigenomics; Histones; Humans; Lysine; Methylation; Neoplasms | 2012 |
Recognition of methylated histones: new twists and variations.
Topics: Animals; Chromatin; DNA; Histones; Humans; Lysine; Methylation; Models, Molecular; Nucleosomes; Protein Conformation | 2011 |
Polycomb group complexes mediate developmental transitions in plants.
Topics: Animals; Arabidopsis Proteins; Chromatin; Drosophila Proteins; Epigenesis, Genetic; Flowers; Germ Cells, Plant; Lysine; MADS Domain Proteins; Methylation; Multiprotein Complexes; Plant Development; Plant Proteins; Plants; Reproduction; Seeds | 2012 |
Lysine methylation: beyond histones.
Topics: Acetylation; Animals; Histone Demethylases; Histone-Lysine N-Methyltransferase; Humans; Lysine; Methylation; Methyltransferases; Mice; Protein Methyltransferases; Protein Processing, Post-Translational; Tumor Suppressor Protein p53 | 2012 |
Many keys to push: diversifying the 'readership' of plant homeodomain fingers.
Topics: Amino Acid Motifs; Amino Acid Sequence; DNA-Binding Proteins; Epigenesis, Genetic; Histone Code; Histones; Homeodomain Proteins; Humans; Lysine; Methylation; Models, Molecular; Plant Proteins; Plants; Protein Processing, Post-Translational; Sequence Alignment; SUMO-1 Protein; Ubiquitin-Protein Ligases | 2012 |
Understanding the language of Lys36 methylation at histone H3.
Topics: Animals; Comprehension; Gene Expression; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Models, Biological; Protein Processing, Post-Translational | 2012 |
Structural biology of the chromodomain: form and function.
Topics: Amino Acid Motifs; Animals; Chromatin; Drosophila melanogaster; Histones; Humans; Lysine; Methylation; Peptides; Phosphorylation; Protein Binding; Protein Conformation; Protein Processing, Post-Translational; Protein Structure, Secondary; Protein Structure, Tertiary; Transcription, Genetic | 2012 |
PR-Set7 and H4K20me1: at the crossroads of genome integrity, cell cycle, chromosome condensation, and transcription.
Topics: Animals; Cell Cycle; Chromosomes; DNA Damage; Gene Expression Regulation; Genome; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation | 2012 |
[Epigenetic regulation of histone H3 lysine 9 methylation in leukemia].
Topics: Animals; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Histones; Humans; Leukemia; Lysine; Methylation | 2012 |
WRAD: enabler of the SET1-family of H3K4 methyltransferases.
Topics: Animals; Chromatin; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Multiprotein Complexes | 2012 |
Lysine methylation and the regulation of p53.
Topics: Animals; Humans; Lysine; Methylation; Models, Biological; Tumor Suppressor Protein p53 | 2012 |
Post-translational modifications of lysine in DNA-damage repair.
Topics: Acetylation; Animals; DNA Repair; Humans; Lysine; Methylation; Models, Biological; Protein Processing, Post-Translational | 2012 |
Discovery of lysine post-translational modifications through mass spectrometric detection.
Topics: Animals; Humans; Lysine; Mass Spectrometry; Methylation; Protein Processing, Post-Translational; Ubiquitination | 2012 |
Oncoepigenomics: making histone lysine methylation count.
Topics: Animals; Epigenomics; Histone Demethylases; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Neoplasms | 2012 |
Epigenetic inheritance mediated by histone lysine methylation: maintaining transcriptional states without the precise restoration of marks?
Topics: Animals; Chromatin Assembly and Disassembly; Epigenetic Repression; Histones; Inheritance Patterns; Lysine; Methylation; Mitosis; Models, Genetic; Nucleosomes; S Phase; Saccharomyces cerevisiae; Silent Information Regulator Proteins, Saccharomyces cerevisiae; Transcription, Genetic | 2013 |
Tipping the lysine methylation balance in disease.
Topics: Histone-Lysine N-Methyltransferase; Humans; Lysine; Methylation; Mutation; Neoplasms; Nervous System Diseases | 2013 |
Histone lysine methylation dynamics: establishment, regulation, and biological impact.
Topics: Animals; Histone Demethylases; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation | 2012 |
One, two, three: how histone methylation is read.
Topics: Animals; Arginine; Chromatin; Epigenesis, Genetic; Histones; Humans; Lysine; Methylation; Protein Processing, Post-Translational | 2012 |
Histone H4 lysine 20 methylation: key player in epigenetic regulation of genomic integrity.
Topics: Animals; Cell Cycle; Chromatin; DNA Damage; DNA Replication; Epigenesis, Genetic; Genomic Instability; Histone-Lysine N-Methyltransferase; Histones; Humans; Intracellular Signaling Peptides and Proteins; Lysine; Methylation; Tumor Suppressor p53-Binding Protein 1 | 2013 |
Regulation of nucleosome dynamics by histone modifications.
Topics: Acetylation; Acylation; Adenosine Diphosphate; Chromatin; DNA; DNA Replication; Gene Expression Regulation; Glycosylation; Histones; Lysine; Methylation; Nucleosomes | 2013 |
Transcriptional regulation by the Set7 lysine methyltransferase.
Topics: Animals; Chromatin; Chromosomal Proteins, Non-Histone; Gene Expression Regulation; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Transcription Factors; Transcription, Genetic | 2013 |
Spp1 at the crossroads of H3K4me3 regulation and meiotic recombination.
Topics: Animals; DNA Breaks, Double-Stranded; DNA-Binding Proteins; Endodeoxyribonucleases; Histone-Lysine N-Methyltransferase; Histones; Lysine; Meiosis; Methylation; Protein Subunits; Recombination, Genetic; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins | 2013 |
On your histone mark, SET, methylate!
Topics: Amino Acid Sequence; Chromosomal Proteins, Non-Histone; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Models, Biological; Molecular Sequence Data | 2013 |
The path of lysine to pyrrolysine.
Topics: Intramolecular Transferases; Ligases; Lysine; Methylation; Oxidation-Reduction | 2013 |
Small molecule epigenetic inhibitors targeted to histone lysine methyltransferases and demethylases.
Topics: Allosteric Site; Animals; Chromatin; Drug Design; Drug Evaluation, Preclinical; Enzyme Inhibitors; Epigenesis, Genetic; Genome; Histone Demethylases; Histone-Lysine N-Methyltransferase; Histones; Humans; Inhibitory Concentration 50; Lysine; Methylation; Nucleosomes | 2013 |
Histone H3 lysine methylation in cognition and intellectual disability disorders.
Topics: Animals; Cognition Disorders; Epigenesis, Genetic; Histones; Humans; Intellectual Disability; Lysine; Methylation; Protein Processing, Post-Translational | 2013 |
Decoding the histone code: Role of H3K36me3 in mismatch repair and implications for cancer susceptibility and therapy.
Topics: Base Pair Mismatch; Histone Code; Humans; Lysine; Methylation; Neoplasms; Polycomb Repressive Complex 2 | 2013 |
Mind the methyl: methyllysine binding proteins in epigenetic regulation.
Topics: Carrier Proteins; Drug Discovery; Epigenesis, Genetic; Histones; Humans; Lysine; Methylation | 2014 |
The histone methyltransferase Dot1/DOT1L as a critical regulator of the cell cycle.
Topics: Animals; Cell Cycle; Cellular Reprogramming; Chromatin; DNA Damage; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Methyltransferases; Neoplasms | 2014 |
Understanding the relationship between DNA methylation and histone lysine methylation.
Topics: Animals; CpG Islands; DNA Methylation; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Protein Processing, Post-Translational | 2014 |
An unexpected journey: lysine methylation across the proteome.
Topics: Animals; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Protein Processing, Post-Translational; Proteome | 2014 |
Readers of histone methylarginine marks.
Topics: Arginine; Chromatin; Epigenesis, Genetic; Histones; Humans; Lysine; Methylation; Protein Binding; Protein Interaction Domains and Motifs; Protein Processing, Post-Translational; Protein-Arginine N-Methyltransferases; Repressor Proteins; Ribonucleoproteins; RNA-Binding Proteins; Signal Transduction | 2014 |
Chromatin dynamics: interplay between remodeling enzymes and histone modifications.
Topics: Acetylation; Animals; Chromatin; Chromatin Assembly and Disassembly; Chromosomal Proteins, Non-Histone; DNA Repair; Epigenesis, Genetic; Eukaryotic Cells; Histones; Humans; Lysine; Methylation; Protein Binding; Protein Processing, Post-Translational; Transcription Factors; Transcription, Genetic | 2014 |
Enhancer biology and enhanceropathies.
Topics: Animals; Chromatin; Chromosome Mapping; Computational Biology; Drosophila melanogaster; Enhancer Elements, Genetic; Gene Expression Regulation; Genome-Wide Association Study; Histones; Humans; Lysine; Methylation; Mutation; Regulatory Sequences, Nucleic Acid; RNA Polymerase II; RNA, Untranslated | 2014 |
Hitting the 'mark': interpreting lysine methylation in the context of active transcription.
Topics: Animals; DNA Methylation; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Protein Processing, Post-Translational; Transcription, Genetic | 2014 |
Histone lysine methylation and chromatin replication.
Topics: Animals; Chromatin; DNA Replication; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Protein Processing, Post-Translational | 2014 |
The functional diversity of protein lysine methylation.
Topics: Acetylation; Amino Acid Sequence; Histones; Lysine; Methylation; Protein Processing, Post-Translational; Proteins; Systems Biology; Ubiquitination | 2014 |
Towards understanding methyllysine readout.
Topics: Chromosomal Proteins, Non-Histone; Epigenesis, Genetic; Histones; Humans; Lysine; Methylation; Models, Molecular; Nucleosomes; Protein Binding; Protein Interaction Domains and Motifs; Protein Processing, Post-Translational; Protein Structure, Tertiary; Small Molecule Libraries; Transcription Factors | 2014 |
Structural biology-based insights into combinatorial readout and crosstalk among epigenetic marks.
Topics: DNA Methylation; Epigenesis, Genetic; Eukaryotic Cells; Histones; Humans; Lysine; Methylation; Models, Molecular; Nucleosomes; Protein Binding; Protein Interaction Domains and Motifs; Protein Processing, Post-Translational; Signal Transduction; Transcription Factors; Transcription, Genetic | 2014 |
[The mechanism of histone lysine methylation of plant involved in gene expression and regulation].
Topics: Gene Expression Regulation, Plant; Histones; Lysine; Methylation; Plant Development; Plants | 2014 |
Examining the impact of gene variants on histone lysine methylation.
Topics: Animals; Histone Demethylases; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Mutation; Neoplasms; Polymorphism, Single Nucleotide | 2014 |
Molecular basis for substrate recognition by lysine methyltransferases and demethylases.
Topics: Animals; Histone Demethylases; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Models, Molecular; Protein Binding; Substrate Specificity | 2014 |
H3K4me3 breadth is linked to cell identity and transcriptional consistency.
Topics: Animals; Artificial Intelligence; Cells; Genomics; Histone Code; Histones; Humans; Lysine; Methylation; Mice, Inbred C57BL; Neural Stem Cells; RNA Polymerase II; Transcription, Genetic | 2014 |
Structural and functional coordination of DNA and histone methylation.
Topics: Arginine; Chromatin; DNA; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation; Histones; Lysine; Methylation; Models, Genetic; Models, Molecular; Oxidation-Reduction; Protein Structure, Tertiary | 2014 |
Histone lysine methylation in diabetic nephropathy.
Topics: Animals; Blood Glucose; Chromatin Assembly and Disassembly; Diabetic Nephropathies; Gene Expression Regulation; Histone Demethylases; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Signal Transduction | 2014 |
The role of microRNAs in diabetic nephropathy.
Topics: Acetylation; Animals; Chromatin; Diabetic Nephropathies; Disease Models, Animal; Disease Progression; Dogs; Epigenesis, Genetic; Epigenomics; Histones; Humans; Inflammation; Kidney; Lysine; Methylation; Mice; Mice, Transgenic; MicroRNAs; Rats | 2014 |
Lysine methylation in cancer: SMYD3-MAP3K2 teaches us new lessons in the Ras-ERK pathway.
Topics: Adenocarcinoma; Antineoplastic Agents; Gene Expression Regulation, Neoplastic; Histone-Lysine N-Methyltransferase; Humans; Lung Neoplasms; Lysine; MAP Kinase Kinase Kinase 2; MAP Kinase Kinase Kinases; Methylation; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Pancreatic Neoplasms; Protein Binding; Protein Kinase Inhibitors; Protein Phosphatase 2; Proto-Oncogene Proteins p21(ras); Signal Transduction | 2014 |
Targeting histone lysine methylation in cancer.
Topics: Animals; Antineoplastic Agents; Histone Demethylases; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Molecular Targeted Therapy; Neoplasms; Signal Transduction | 2015 |
Critical roles of non-histone protein lysine methylation in human tumorigenesis.
Topics: Cell Transformation, Neoplastic; Chromosomal Proteins, Non-Histone; Histone-Lysine N-Methyltransferase; Humans; Lysine; Methylation; Retinoblastoma Protein; STAT3 Transcription Factor; Tumor Suppressor Protein p53 | 2015 |
Epigenetic regulation by histone demethylases in hypoxia.
Topics: Cardiovascular Diseases; Epigenesis, Genetic; Histones; Humans; Hypoxia; Jumonji Domain-Containing Histone Demethylases; Lysine; Methylation; Models, Genetic; Neoplasms | 2015 |
Stem Cell Depletion by Global Disorganization of the H3K9me3 Epigenetic Marker in Aging.
Topics: Aging; Animals; Biomarkers; Chromobox Protein Homolog 5; Epigenesis, Genetic; Histones; Humans; Lysine; Methylation; Stem Cells | 2015 |
Regulation of cell differentiation and function by the euchromatin histone methyltranserfases G9a and GLP.
Topics: Adipogenesis; Animals; Cell Differentiation; Drosophila melanogaster; Euchromatin; Histone-Lysine N-Methyltransferase; Histones; Humans; Immunity, Cellular; Lysine; Memory; Methylation; Mice; Mice, Knockout; Mouse Embryonic Stem Cells; Neuronal Plasticity; Rats; Substance-Related Disorders | 2016 |
Emerging roles of lysine methylation on non-histone proteins.
Topics: Animals; Estrogen Receptor alpha; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Models, Biological; Protein Processing, Post-Translational; Tumor Suppressor Protein p53 | 2015 |
Histone methylation modifiers in cellular signaling pathways.
Topics: Amino Acid Sequence; Arginine; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; MAP Kinase Signaling System; Methylation; Molecular Sequence Data; NF-kappa B; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-raf; Signal Transduction; Wnt Signaling Pathway | 2015 |
Dynamics of H3K27me3 methylation and demethylation in plant development.
Topics: Gene Expression Regulation, Plant; Histones; Lysine; Methylation; Models, Biological; Plant Development | 2015 |
NF-κB: Regulation by Methylation.
Topics: Animals; Arginine; Gene Expression Regulation; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Histone-Lysine N-Methyltransferase; Humans; Lysine; Methylation; Neoplasm Proteins; NF-kappa B; Protein Processing, Post-Translational; Protein-Arginine N-Methyltransferases; Transcription, Genetic | 2015 |
Histone H3K4 trimethylation: dynamic interplay with pre-mRNA splicing.
Topics: Acetylation; Animals; CpG Islands; Epigenesis, Genetic; Exons; Histone Acetyltransferases; Histone Code; Histone Demethylases; Histone-Lysine N-Methyltransferase; Histones; Humans; Introns; Lysine; Methylation; Nucleosomes; Promoter Regions, Genetic; RNA Precursors; RNA Splicing; Transcription, Genetic | 2016 |
Post-translational control of transcription factors: methylation ranks highly.
Topics: Arginine; Humans; Lysine; Methylation; Protein Processing, Post-Translational; Transcription Factors | 2015 |
Chromatin remodeling and bivalent histone modifications in embryonic stem cells.
Topics: Animals; Chromatin Assembly and Disassembly; Embryonic Stem Cells; Epigenesis, Genetic; Gene Expression Regulation, Developmental; Histone Code; Histones; Humans; Lysine; Methylation; Mice; Promoter Regions, Genetic | 2015 |
Histone H4 Lysine 20 (H4K20) Methylation, Expanding the Signaling Potential of the Proteome One Methyl Moiety at a Time.
Topics: Animals; Chromatin; Epigenesis, Genetic; Histones; Humans; Lysine; Methylation; Protein Processing, Post-Translational; Proteome; Signal Transduction | 2016 |
Modulation of the cytoplasmic functions of mammalian post-transcriptional regulatory proteins by methylation and acetylation: a key layer of regulation waiting to be uncovered?
Topics: Acetylation; Animals; Cytoplasm; Humans; Lysine; Methylation; Models, Genetic; Protein Processing, Post-Translational; Proteome; RNA, Messenger | 2015 |
Molecular Recognition of Lys and Arg Methylation.
Topics: Arginine; Epigenesis, Genetic; Humans; Lysine; Methylation; Protein Binding; Protein Processing, Post-Translational | 2016 |
SET domain-mediated lysine methylation in lower organisms regulates growth and transcription in hosts.
Topics: Amino Acid Sequence; Animals; Host-Pathogen Interactions; Humans; Lysine; Methylation; Prokaryotic Cells; Protein Domains; Transcription, Genetic | 2016 |
Chemical probes for methyl lysine reader domains.
Topics: Humans; Lysine; Methylation; Models, Molecular; Molecular Mimicry; Molecular Probes; Peptides | 2016 |
Advances and challenges in understanding histone demethylase biology.
Topics: Catalysis; Clinical Trials as Topic; Enzyme Inhibitors; Epigenesis, Genetic; Genomics; Histone Demethylases; Histones; Humans; Lysine; Methylation | 2016 |
Host-guest chemistry that directly targets lysine methylation: synthetic host molecules as alternatives to bio-reagents.
Topics: Animals; Binding Sites; Biological Products; Humans; Indicators and Reagents; Lysine; Methylation; Protein Structure, Secondary; Protein Structure, Tertiary | 2016 |
Protein lysine methylation by seven-β-strand methyltransferases.
Topics: Animals; Histone-Lysine N-Methyltransferase; Humans; Lysine; Methylation; Methyltransferases; Protein Processing, Post-Translational; Substrate Specificity | 2016 |
Writers and Erasers of Histone Lysine methylation with Clinically Applied Modulators: Promising Target for Cancer Therapy.
Topics: Antineoplastic Agents; Histones; Humans; Lysine; Methylation; Neoplasms | 2016 |
Approaches and Guidelines for the Identification of Novel Substrates of Protein Lysine Methyltransferases.
Topics: Histone-Lysine N-Methyltransferase; Humans; Lysine; Methylation; Models, Molecular; Reproducibility of Results; Substrate Specificity | 2016 |
Structural aspects of small-molecule inhibition of methyllysine reader proteins.
Topics: Animals; Humans; Lysine; Methylation; Molecular Structure; Protein Binding; Protein Domains; Small Molecule Libraries; Structure-Activity Relationship | 2016 |
Nonhistone Lysine Methylation in the Regulation of Cancer Pathways.
Topics: Cell Transformation, Neoplastic; Chromosomal Proteins, Non-Histone; DNA Damage; Epigenesis, Genetic; Histone-Lysine N-Methyltransferase; Humans; Lysine; Methylation; Neoplasms; Protein Processing, Post-Translational; Signal Transduction | 2016 |
Tug of war: adding and removing histone lysine methylation in Arabidopsis.
Topics: Animals; Arabidopsis; Histones; Lysine; Methylation | 2016 |
Beyond histones - the expanding roles of protein lysine methylation.
Topics: Acetylation; Animals; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Phosphorylation; Protein Interaction Maps; Protein Processing, Post-Translational | 2017 |
Methyllysine binding domains: Structural insight and small molecule probe development.
Topics: Binding Sites; Humans; Lysine; Methylation; Molecular Probes; Molecular Structure; Small Molecule Libraries | 2017 |
Histone Lysine Methylation and Neurodevelopmental Disorders.
Topics: Animals; Epigenesis, Genetic; Histones; Humans; Lysine; Methylation; Neurodevelopmental Disorders; Protein Processing, Post-Translational | 2017 |
Orchestration of H3K27 methylation: mechanisms and therapeutic implication.
Topics: Animals; Gene Silencing; Heterochromatin; Histone Demethylases; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Protein Processing, Post-Translational | 2018 |
Chemical biology approaches for studying posttranslational modifications.
Topics: Acetylation; Chemistry Techniques, Synthetic; Codon, Terminator; Genetic Code; Glycosylation; Humans; Lysine; Methylation; Nitrates; Phosphorylation; Protein Processing, Post-Translational; Proteome; Selenocysteine; Sulfates; Ubiquitination | 2018 |
Histone lysine methylation and congenital heart disease: From bench to bedside (Review).
Topics: Animals; Heart; Heart Defects, Congenital; Histones; Humans; Lysine; Methylation; Translational Research, Biomedical | 2017 |
Broad Chromatin Domains: An Important Facet of Genome Regulation.
Topics: Animals; Caenorhabditis elegans; Chromatin; Chromatin Assembly and Disassembly; Chromatin Immunoprecipitation; Drosophila melanogaster; Epigenesis, Genetic; Genome; Histones; Lysine; Methylation; Mice; Promoter Regions, Genetic; Protein Processing, Post-Translational | 2017 |
Histone Methyltransferase EZH2: A Therapeutic Target for Ovarian Cancer.
Topics: Enhancer of Zeste Homolog 2 Protein; Female; Gene Expression Regulation, Neoplastic; Histones; Humans; Lysine; Methylation; Molecular Targeted Therapy; Ovarian Neoplasms; Small Molecule Libraries | 2018 |
Synthetic Receptors for the Recognition and Discrimination of Post-Translationally Methylated Lysines.
Topics: Antibodies; Calixarenes; Lysine; Macrocyclic Compounds; Methylation; Phenylalanine; Protein Binding; Protein Processing, Post-Translational; Proteins; Receptors, Artificial; Reproducibility of Results | 2018 |
Emerging impacts of biological methylation on genetic information.
Topics: Animals; Arginine; Demethylation; DNA; DNA Methylation; Humans; Lysine; Methylation; Methyltransferases; Protein Biosynthesis; Proteins; RNA | 2019 |
Lysine methylation: Implications in neurodegenerative disease.
Topics: Animals; Epigenesis, Genetic; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Neurodegenerative Diseases; Protein Processing, Post-Translational; Signal Transduction | 2019 |
Lysine methylation of transcription factors in cancer.
Topics: Antineoplastic Agents; DNA-Binding Proteins; Gene Expression Regulation, Neoplastic; Histone Demethylases; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Neoplasms; Protein Processing, Post-Translational; Protein Stability; Transcription Factors | 2019 |
Molecular Mechanisms Directing PRC2 Recruitment and H3K27 Methylation.
Topics: Animals; Chromatin Assembly and Disassembly; DNA Methylation; Histones; Humans; Lysine; Methylation; Polycomb Repressive Complex 2; Protein Binding | 2019 |
[Histone H3K27me3 in the regulation of skeletal muscle development].
Topics: Animals; Cell Proliferation; Histones; Lysine; Mammals; Methylation; Muscle Cells; Muscle Development; Muscle, Skeletal; Nucleosomes | 2019 |
Lysine methylation regulates nervous system diseases.
Topics: Animals; Epigenesis, Genetic; Histone Demethylases; Humans; Lysine; Methylation; Methyltransferases; Nervous System Diseases | 2019 |
Lysine methylation signaling of non-histone proteins in the nucleus.
Topics: Cell Nucleus; Histone-Lysine N-Methyltransferase; Humans; Lysine; Methylation; Protein Array Analysis; Signal Transduction; Transcription Factors | 2019 |
Introduction to the multi-author review on methylation in cellular physiology.
Topics: Arginine; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Protein Processing, Post-Translational; Protein-Arginine N-Methyltransferases | 2019 |
Lysine-specific post-translational modifications of proteins in the life cycle of viruses.
Topics: Acetylation; Humans; Life Cycle Stages; Lysine; Methylation; Phosphorylation; Protein Processing, Post-Translational; Ubiquitination; Viral Proteins; Virus Replication; Viruses | 2019 |
Lysine Methylation Regulators Moonlighting outside the Epigenome.
Topics: Animals; Epigenome; Humans; Lysine; Methylation; Neoplasm Proteins; Neoplasms; Protein Processing, Post-Translational; Signal Transduction | 2019 |
The control of gene expression and cell identity by H3K9 trimethylation.
Topics: Animals; Feedback, Physiological; Gene Expression Regulation, Developmental; Heterochromatin; Histones; Humans; Lysine; Methylation | 2019 |
Using Yeast to Define the Regulatory Role of Protein Lysine Methylation.
Topics: Chromatin; Gene Expression Regulation, Fungal; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Protein Processing, Post-Translational; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Signal Transduction | 2020 |
Insights into The Function and Regulation of Jumonji C Lysine Demethylases as Hypoxic Responsive Enzymes.
Topics: Biocatalysis; Chromosomal Proteins, Non-Histone; Histone Demethylases; Histones; Humans; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Jumonji Domain-Containing Histone Demethylases; Kinetics; Lysine; Methylation; Oxygen; Prolyl Hydroxylases; Protein Processing, Post-Translational; Signal Transduction | 2020 |
Lysine Methyltransferases Signaling: Histones are Just the Tip of the Iceberg.
Topics: Chromosomal Proteins, Non-Histone; Gene Expression Regulation, Neoplastic; Histone Demethylases; Histones; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Jumonji Domain-Containing Histone Demethylases; Lysine; Methylation; Neoplasms; Protein Processing, Post-Translational; Signal Transduction | 2020 |
Protein lysine methylation in the regulation of anoxia tolerance in the red eared slider turtle, Trachemys scripta elegans.
Topics: Adaptation, Physiological; Animals; Gene Expression Regulation; Hypoxia; Lysine; Methylation; Protein Processing, Post-Translational; Turtles | 2020 |
The function of histone lysine methylation related SET domain group proteins in plants.
Topics: Arabidopsis; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Plant Proteins; PR-SET Domains | 2020 |
The Chemical Biology of Reversible Lysine Post-translational Modifications.
Topics: Acetylation; Lysine; Lysine Acetyltransferases; Methylation; Protein Methyltransferases; Small Molecule Libraries; Ubiquitin-Specific Proteases; Ubiquitination | 2020 |
Current understanding of plant Polycomb group proteins and the repressive histone H3 Lysine 27 trimethylation.
Topics: Animals; Arabidopsis; Arabidopsis Proteins; Epigenesis, Genetic; Gene Silencing; Histones; Lysine; Methylation; Polycomb-Group Proteins; RNA, Untranslated; Transcription Factors | 2020 |
Reciprocal skeletal phenotypes of PRC2-related overgrowth and Rubinstein-Taybi syndromes: potential role of H3K27 modifications.
Topics: Acylation; Animals; Disease Models, Animal; Histones; Humans; Lysine; Methylation; Mice; Polycomb-Group Proteins; Rubinstein-Taybi Syndrome | 2020 |
Histone Methyltransferase SETDB1: A Common Denominator of Tumorigenesis with Therapeutic Potential.
Topics: Carcinogenesis; Down-Regulation; Gene Expression Regulation, Neoplastic; Genes, Tumor Suppressor; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Neoplasm Proteins; Neoplasms; Protein Processing, Post-Translational; Repressor Proteins; Transcription, Genetic | 2021 |
Methylation of histone 4's lysine 20: a critical analysis of the state of the field.
Topics: Animals; Cell Cycle; Embryonic Development; Histones; Humans; Lysine; Methylation; Neoplasms | 2021 |
Histone lysine methyltransferase SETDB1 as a novel target for central nervous system diseases.
Topics: Central Nervous System Diseases; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation | 2021 |
H3K4 trimethylation dynamics impact diverse developmental and environmental responses in plants.
Topics: Chromatin; Gene Expression Regulation, Plant; Histones; Lysine; Methylation; Plant Development; Plant Proteins; Plants | 2021 |
Epigenetics and beyond: targeting writers of protein lysine methylation to treat disease.
Topics: Animals; Antineoplastic Agents; Drug Development; Epigenesis, Genetic; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Protein Processing, Post-Translational | 2021 |
Noncanonical Functions of the Polycomb Group Protein EZH2 in Breast Cancer.
Topics: Breast Neoplasms; Enhancer of Zeste Homolog 2 Protein; Female; Histones; Humans; Lysine; Methylation | 2021 |
Coordinated methyl readers: Functional communications in cancer.
Topics: Histones; Humans; Lysine; Methylation; Methyltransferases; Neoplasms | 2022 |
Allosteric regulation of histone lysine methyltransferases: from context-specific regulation to selective drugs.
Topics: Allosteric Regulation; Drug Development; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Pharmaceutical Preparations; Protein Binding; Protein Conformation; Protein Subunits | 2021 |
Past, present, and perspectives of protein N-terminal methylation.
Topics: Amines; Arginine; Chromatin; DNA; DNA Repair; Humans; Lysine; Methylation; Methyltransferases; Peptidomimetics; Protein Binding; Protein Processing, Post-Translational; Proteins; Signal Transduction; Substrate Specificity | 2021 |
Improved methods for targeting epigenetic reader domains of acetylated and methylated lysine.
Topics: Acetylation; Allosteric Regulation; Allosteric Site; Epigenesis, Genetic; Histones; Humans; Ligands; Lysine; Methylation; Peptidomimetics; Protein Binding; Protein Conformation; Protein Processing, Post-Translational; Structure-Activity Relationship | 2021 |
Not just a writer: PRC2 as a chromatin reader.
Topics: Animals; Chromatin; Epigenesis, Genetic; Genome; Histones; Humans; Lysine; Methylation; Polycomb Repressive Complex 2; Protein Binding | 2021 |
The role of demethylases in cardiac development and disease.
Topics: Adult; Animals; Chromatin; Chromatin Assembly and Disassembly; Enzyme Inhibitors; Epigenesis, Genetic; Heart; Heart Failure; Histones; Humans; Jumonji Domain-Containing Histone Demethylases; Lysine; Methylation; Myocardium; Protein Processing, Post-Translational | 2021 |
New connections between ubiquitylation and methylation in the co-transcriptional histone modification network.
Topics: Histone Code; Histones; Humans; Lysine; Methylation; Ubiquitination | 2021 |
Ready, SET, Go: Post-translational regulation of the histone lysine methylation network in budding yeast.
Topics: Epigenesis, Genetic; Histones; Lysine; Methylation; Phosphorylation; Protein Processing, Post-Translational; Saccharomycetales; Ubiquitination | 2021 |
Dynamic changes of histone methylation in mammalian oocytes and early embryos.
Topics: Animals; Histones; Lysine; Methylation; Oocytes; Protein Processing, Post-Translational | 2022 |
Non-histone Methylation of SET7/9 and its Biological Functions.
Topics: Animals; Biological Phenomena; Cell Proliferation; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Male; Methylation | 2022 |
Molecular mechanisms in governing genomic stability and tumor suppression by the SETD2 H3K36 methyltransferase.
Topics: Animals; Carcinogenesis; Chromatin; Genomic Instability; Histones; Humans; Lysine; Mammals; Methylation; Neoplasms | 2022 |
Emerging roles of JMJD3 in cancer.
Topics: Apoptosis; Female; Histones; Humans; Jumonji Domain-Containing Histone Demethylases; Lysine; Male; Methylation; Neoplasms | 2022 |
The SUV4-20H Histone Methyltransferases in Health and Disease.
Topics: Chromatin; Histone Methyltransferases; Histones; Lysine; Methylation | 2022 |
Disorders of histone methylation: Molecular basis and clinical syndromes.
Topics: Histone Demethylases; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Syndrome | 2022 |
Chemical biology and pharmacology of histone lysine methylation inhibitors.
Topics: Biology; Epigenesis, Genetic; Histones; Humans; Intracellular Signaling Peptides and Proteins; Lysine; Methylation; Neoplasms; Protein Processing, Post-Translational | 2022 |
Histone Lysine Methylation Modification and Its Role in Vascular Calcification.
Topics: Aged; Histones; Humans; Lysine; Methylation; Prospective Studies; Vascular Calcification | 2022 |
Targeting histone demethylases as a potential cancer therapy (Review).
Topics: Histone Demethylases; Histones; Humans; Lysine; Methylation; Neoplasms | 2022 |
Role of histone methylation in skin cancers: Histone methylation-modifying enzymes as a new class of targets for skin cancer treatment.
Topics: Histone Demethylases; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Skin Neoplasms | 2023 |
Chemical tools targeting readers of lysine methylation.
Topics: Chromatin; Histones; Lysine; Methylation; Protein Binding | 2023 |
Human seven-β-strand (METTL) methyltransferases - conquering the universe of protein lysine methylation.
Topics: Histones; Humans; Lysine; Methylation; Methyltransferases; Protein Conformation, beta-Strand; Protein Methyltransferases; Protein Processing, Post-Translational | 2023 |
The engagement of histone lysine methyltransferases with nucleosomes: structural basis, regulatory mechanisms, and therapeutic implications.
Topics: Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Methyltransferases; Nucleosomes | 2023 |
Recent advances in the development of peptide-based inhibitors targeting epigenetic readers of histone lysine acetylation and methylation marks.
Topics: Acetylation; Epigenesis, Genetic; Histones; Lysine; Methylation; Peptides | 2023 |
Post-translational modifications of lysine-specific demethylase 1.
Topics: Histone Demethylases; Histones; Humans; Lysine; Methylation; Protein Processing, Post-Translational | 2023 |
Lysine methylation signaling in skeletal muscle biology: from myogenesis to clinical insights.
Topics: Biology; Histones; Lysine; Methylation; Muscle Development; Muscle, Skeletal | 2023 |
2 trial(s) available for lysine and isomethyleugenol
| Article | Year |
|---|---|
Effects of genetic variation in H3K79 methylation regulatory genes on clinical blood pressure and blood pressure response to hydrochlorothiazide.
Topics: Antihypertensive Agents; Black or African American; Blood Pressure; Cohort Studies; Demography; Female; Genetic Association Studies; Genotype; Histones; Humans; Hydrochlorothiazide; Lysine; Male; Methylation; Middle Aged; Polymorphism, Single Nucleotide; Treatment Outcome | 2012 |
The association between progression of atherosclerosis and the methylated amino acids asymmetric dimethylarginine and trimethyllysine.
Topics: Adenosine; Aged; Arginine; Coronary Angiography; Coronary Artery Disease; Disease Progression; Ethionine; Female; Folic Acid; Follow-Up Studies; Humans; Lysine; Male; Methylation; Middle Aged; Treatment Outcome; Vitamin B 12; Vitamin B 6; Vitamin B Complex | 2013 |
2332 other study(ies) available for lysine and isomethyleugenol
| Article | Year |
|---|---|
Nuclear-magnetic-resonance-spectroscopic studies of the amino groups of insulin.
Topics: Amines; Animals; Cattle; Chemical Phenomena; Chemistry; Hydrogen-Ion Concentration; Insulin; Lysine; Magnetic Resonance Spectroscopy; Methylation; Protein Conformation | 1977 |
The formation and cleavage of lysinoalanine crosslinks.
Topics: Alanine; Chemical Phenomena; Chemistry; Hydrogen-Ion Concentration; Iodides; Keratins; Kinetics; Lysine; Methylation; Spectrophotometry, Ultraviolet; Temperature | 1977 |
Inactivation of the ribosomal protein S1 in polyuridylate binding by reductive methylation of the lysyl-ammonium groups.
Topics: Hydrogen-Ion Concentration; Kinetics; Lysine; Methylation; Oxidation-Reduction; Poly U; Protein Binding; Ribosomal Proteins; RNA, Transfer | 1978 |
Methylated amino acid residues of proteins of brain and other organs.
Topics: Amino Acids; Animals; Arginine; Brain Chemistry; Cell Nucleus; Cerebrosides; Growth; Histidine; Liver; Lysine; Methylation; Microsomes; Mitochondria; Mitochondria, Liver; Myelin Basic Protein; Protein Biosynthesis; Rabbits; Rats | 1975 |
Methylases of myelin basic protein and histone in rat brain.
Topics: Animals; Arginine; Brain; Carbon Radioisotopes; Cattle; Chromatography, Ion Exchange; Histones; Humans; Liver; Lysine; Methylation; Methyltransferases; Myelin Basic Protein; Rabbits; Rats; Subcellular Fractions | 1975 |
Evidence that trimethylation of iso-1-cytochrome c from Saccharomyces cerevisiae does not alter its functional properties [proceedings].
Topics: Cytochrome c Group; Kinetics; Lysine; Methylation; Saccharomyces cerevisiae; Structure-Activity Relationship | 1976 |
Protein-RNA interactions in the Escherichia coli ribosome: L24 protein-23 S RNA complex.
Topics: Bacterial Proteins; Binding Sites; Escherichia coli; Lysine; Methylation; Nucleic Acid Conformation; Protein Binding; Ribonucleases; Ribosomal Proteins; Ribosomes; RNA, Bacterial; RNA, Ribosomal; Structure-Activity Relationship | 1976 |
The nature and functions of specific immune response genes and their products.
Topics: Alanine; Animals; Antibody Formation; Antibody Specificity; Cross Reactions; Genes, MHC Class II; Glutamates; Immunoglobulin Idiotypes; Lymphocytes; Lysine; Methylation; Mice; Peptides; Serum Albumin, Bovine; Tyrosine | 1978 |
In vivo methylation of elongation factor Tu of Escherichia coli.
Topics: Amino Acids; Escherichia coli; Immunodiffusion; Kinetics; Lysine; Methionine; Methylation; Molecular Weight; Peptide Elongation Factors | 1979 |
Carnitine biosynthesis in Neurospora crassa: enzymatic conversion of lysine to epsilon-N-trimethyllysine.
Topics: Carnitine; Cell-Free System; Choline; Enzyme Repression; Lysine; Methionine; Methylation; Methyltransferases; Neurospora; Neurospora crassa | 1976 |
Preparation of radioactive epsilon-N-methylated lysines not involving elaborate organic synthesis.
Topics: Carbon Radioisotopes; Chemical Phenomena; Chemistry; Formaldehyde; Isotope Labeling; Lysine; Methylation; Neurospora crassa | 1978 |
The influence of amino acid substitutions on the conformational energy of cytochrome c.
Topics: Amino Acid Sequence; Amino Acids; Animals; Binding Sites; Calorimetry; Cytochrome c Group; Horses; Lysine; Methylation; Myocardium; Protein Binding; Protein Conformation; Thermodynamics; X-Ray Diffraction | 1975 |
Cytochrome c-specific protein methylase III from Neurospora crassa.
Topics: Chymotrypsin; Cytochrome c Group; Histone-Lysine N-Methyltransferase; Kinetics; Lysine; Methylation; Neurospora; Neurospora crassa; Protein Methyltransferases; Subcellular Fractions | 1977 |
Evidence that trimethylation of iso-I-cytochrome c from Saccharomyces cerevisiae affects interaction with the mitochondrion.
Topics: Animals; Binding Sites; Chemical Phenomena; Chemistry; Cytochrome c Group; Isoenzymes; Kinetics; Lysine; Methylation; Mitochondria; Mitochondria, Heart; Mitochondria, Liver; Protein Binding; Saccharomyces cerevisiae | 1978 |
Calcium dependent activator protein of cyclic nucleotide phosphodiesterase from rat and bovine brain; presence of N-epsilon-trimethyllysine residue.
Topics: 2',3'-Cyclic-Nucleotide Phosphodiesterases; Animals; Brain Chemistry; Calcium; Cattle; Enzyme Activation; Lysine; Methylation; Nerve Tissue Proteins; Phosphoric Diester Hydrolases; Rats | 1978 |
The cytochrome c oxidase binding site on cytochrome c. Differential chemical modification of lysine residues in free and oxidase-bound cytochrome c.
Topics: Acetylation; Amino Acids; Anhydrides; Binding Sites; Cytochrome c Group; Electron Transport Complex IV; Formaldehyde; Lysine; Methylation; Oxidation-Reduction; Peptide Fragments; Protein Binding | 1978 |
Proton-magnetic-resonance studies of the lysine residues of ribonuclease A.
Topics: Binding Sites; Borohydrides; Formaldehyde; Histidine; Hydrogen-Ion Concentration; Lysine; Magnetic Resonance Spectroscopy; Methylation; Phosphates; Protein Binding; Protein Conformation; Protein Denaturation; Protons; Ribonucleases; Temperature | 1975 |
Identification of N-methylated basic amino acids from human adult teeth.
Topics: Adult; Arginine; Chromatography, Gas; Chromatography, Thin Layer; Humans; Lysine; Methylation; Tooth | 1978 |
Displacement and aberrant methylation in vitro of H-1 histone in rat liver nuclei after half-saturation of chromatin with polycations.
Topics: Animals; Cations; Cell Nucleus; Chromatin; Histones; Lysine; Methylation; Methyltransferases; Polylysine; Protamines; Rats; S-Adenosylmethionine; Spermidine | 1978 |
Genetics of ribosomal protein methylation in Escherichia coli. I. A mutant deficient in methylation of protein L11.
Topics: Amino Acids; Bacterial Proteins; Escherichia coli; In Vitro Techniques; Lysine; Methylation; Mutation; Ribosomal Proteins; Ribosomes | 1977 |
Temperature-dependent variation in the extent of methylation of ribosomal proteins L7 and L12 in Escherichia coli.
Topics: Bacterial Proteins; Escherichia coli; Lysine; Methylation; Ribosomal Proteins; Temperature | 1978 |
The methylation and demethylation of protein lysine residues.
Topics: Histone-Lysine N-Methyltransferase; Histones; Lysine; Methods; Methylation; Oxidoreductases, N-Demethylating; Protein Methyltransferases; Proteins | 1978 |
Methods for the assessment of histone methylation.
Topics: Cell Nucleus; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methods; Methylation; Protein Methyltransferases | 1978 |
Reactivity of amino groups in various complexes of the peptide chain elongation factor EF-Tu from Escherichia coli. A new method of competitive labelling using reductive methylation.
Topics: Amino Acids; Bacterial Proteins; Binding, Competitive; Escherichia coli; Lysine; Methods; Methylation; Peptide Elongation Factors; Protein Conformation | 1978 |
Location of the site of methylation in elongation factor Tu.
Topics: Amino Acid Sequence; Escherichia coli; Lysine; Methylation; Peptide Elongation Factors; Peptide Fragments; Tritium; Trypsin | 1979 |
Introduction of methyl groups from epsilon-N-methyllysine into the one-carbon pool.
Topics: Animals; Betaine; Carnitine; Chickens; Choline; Liver; Lysine; Methylation; Tissue Distribution | 1979 |
N epsilon-Methyl groups on the lysine residues in histones turn over independently of the polypeptide backbone.
Topics: Animals; Cats; Histones; Kidney; Kinetics; Lysine; Methionine; Methylation | 1979 |
Post-synthetic modifications of nuclear proteins. High mobility group proteins are methylated.
Topics: Amino Acids; Animals; Arginine; Cattle; Lysine; Methylation; Molecular Weight; Nucleoproteins; Thymus Gland | 1979 |
Effect of modification on inhibitory amino acids on arginase activity.
Topics: Amino Acids; Animals; Arginase; Cattle; Humans; Keto Acids; Liver; Lysine; Maple Syrup Urine Disease; Methylation; Ornithine; Structure-Activity Relationship | 1978 |
13C NMR studies of ribonuclease A methylated with [13C]Formaldehyde.
Topics: Animals; Carbon Isotopes; Cattle; Formaldehyde; Kinetics; Lysine; Magnetic Resonance Spectroscopy; Methylation; Pancreas; Ribonucleases | 1979 |
Ontogenetic changes in the content of methylated amino acids in rodent skeletal muscle.
Topics: Aging; Animals; Arginine; Cricetinae; Histidine; Lysine; Male; Methylation; Methylhistidines; Mice; Muscle Development; Muscles; Myosins; Rats | 1977 |
Methylation of the lysine residues of monellin.
Topics: Amino Acids; Chemical Phenomena; Chemistry; Chromatography, Gel; Electrophoresis, Polyacrylamide Gel; Lysine; Methylation; Peptide Fragments; Plant Proteins; Sweetening Agents; Taste | 1978 |
[Preparation and characteristics of carboxymethylated lysozyme derivatives].
Topics: Chromatography, Ion Exchange; Histidine; Iodoacetates; Lysine; Methylation; Muramidase; Osmolar Concentration | 1978 |
Studies on the uptake of N-E-3H-trimethyl-L-lysine in the organs of mice with NK/Ly ascites tumors.
Topics: Animals; Ascites; Biological Transport; Chromatography, Thin Layer; Extracellular Space; Female; Lysine; Methylation; Mice; Neoplasms, Experimental; Tissue Distribution | 1978 |
Relationship between rates of methylation and synthesis of heart protein.
Topics: Animals; Biological Transport; Cycloheximide; Histidine; Hypophysectomy; Kinetics; Lysine; Male; Methionine; Methylation; Muscle Proteins; Myocardium; Protein Biosynthesis; Rats | 1979 |
Synthesis and degradation of methylated proteins of mouse organs: correlation with protein synthesis and degradation.
Topics: Animals; Arginine; Brain; Kidney; Liver; Lysine; Male; Methionine; Methylation; Methyltransferases; Mice; Protein Biosynthesis; Proteins; Puromycin; Spleen; Subcellular Fractions | 1976 |
Methylation of the ribosomal proteins in Escherichia coli. Nature and stoichiometry of the methylated amino acids in 50S ribosomal proteins.
Topics: Amino Acids; Bacterial Proteins; Electrophoresis, Paper; Escherichia coli; Lysine; Methionine; Methylation; Molecular Weight; Protein Binding; Ribosomes | 1975 |
Methylated amino acids in the proteins of bacterial and mammalian cells.
Topics: Amino Acids; Arginine; Bacterial Proteins; Cells, Cultured; Chromatography, Thin Layer; Escherichia coli; Fibroblasts; Histones; Lysine; Methionine; Methylation; Proteins; Ribosomal Proteins; Subcellular Fractions | 1975 |
Improved method for the separation of lysine from N-epsilon-monomethyllysine in plasma using cation-exchange chromatography.
Topics: Animals; Chromatography, Ion Exchange; Lysine; Methods; Methylation; Sheep; Solvents | 1975 |
[Column chromatographic separation of N-B,N-G-dimethyl arginine, N-G,N'G-dimethyl arginine, N-G-monomethyl arginine, N-epsilon-monomethyl lysine, N-epsilon-dimethyl lysine and N-epsilon-trimethyl lysine].
Topics: Arginine; Chromatography; Histidine; Lysine; Methylation; Ornithine | 1975 |
Kinetics of histone methylation in vivo and its relation to the cell cycle in Ehrlich ascites tumor cells.
Topics: Amino Acids; Animals; Carcinoma, Ehrlich Tumor; Cell Division; Electrophoresis, Polyacrylamide Gel; Histones; Kinetics; Lysine; Male; Methylation; Mice; Time Factors | 1975 |
Tissue-specific biosynthesis of epsilon-N-monomethyllysine and epsilon-N-trimethyllysine in skeletal and cardiac muscle myosin: a model for the cell-free study of post-translational amino acid modifications in proteins.
Topics: Animals; Chick Embryo; Chickens; Cytosol; Lysine; Methylation; Methyltransferases; Muscles; Myocardium; Myosins; Organ Specificity; Polyribosomes; Protein Biosynthesis; S-Adenosylmethionine | 1975 |
Sites of in vivo histone methylation in developing trout testis.
Topics: Alanine; Amino Acid Sequence; Animals; Histones; Lysine; Male; Methylation; Peptide Fragments; Spermatogenesis; Testis; Trout; Trypsin | 1975 |
Histone methylation. Its occurrence in different cell types and relation to histone H4 metabolism in developing trout testis.
Topics: Animals; Electrophoresis, Starch Gel; Histones; Lysine; Male; Methionine; Methylation; Testis; Trout | 1975 |
Methylated basic amino acid composition of histones from the various organs from the rat.
Topics: Amino Acids; Animals; Arginine; Brain; Brain Chemistry; Cerebellum; Histidine; Histones; Kidney; Liver; Lysine; Methylation; Rats; Thymus Gland | 1975 |
Role of the lysine and arginine residues of vitellogenin in high affinity binding to vitellogenin receptors in locust oocyte membranes.
Topics: Acetylation; Animals; Arginine; Cell Membrane; Disulfides; Egg Proteins; Grasshoppers; Lysine; Maleic Anhydrides; Methylation; Oocytes; Oxidation-Reduction; Propionates; Receptors, Cell Surface; Sulfhydryl Compounds; Vitellogenins | 1992 |
Methylations of 70,000-Da heat shock proteins in 3T3 cells: alterations by arsenite treatment, by different stages of growth and by virus transformation.
Topics: 3T3 Cells; Animals; Arginine; Arsenic; Arsenites; Avian Sarcoma Viruses; Cell Division; Cell Transformation, Viral; Chromatography, Ion Exchange; Electrophoresis, Gel, Two-Dimensional; Heat-Shock Proteins; Lysine; Methionine; Methylation; Mice; Molecular Weight; omega-N-Methylarginine | 1992 |
In vivo and in vitro methylation of lysine residues of Euglena gracilis histone H1.
Topics: Animals; Chromatography, Gel; Chromatography, High Pressure Liquid; Electrophoresis, Gel, Two-Dimensional; Electrophoresis, Polyacrylamide Gel; Euglena gracilis; Histones; Lysine; Methylation; Protein Processing, Post-Translational; Substrate Specificity | 1992 |
The conformation of apolipoprotein A-I in discoidal and spherical recombinant high density lipoprotein particles. 13C NMR studies of lysine ionization behavior.
Topics: Amino Acid Sequence; Apolipoprotein A-I; Carbon Isotopes; Densitometry; Humans; Hydrogen-Ion Concentration; Kinetics; Lipoproteins, HDL; Lysine; Magnetic Resonance Spectroscopy; Methylation; Protein Conformation; Protein Structure, Secondary; Recombinant Proteins | 1992 |
Helix formation in methylated copolymers of lysine and alanine.
Topics: Alanine; Lysine; Methylation; Molecular Weight; Osmolar Concentration; Peptides; Protein Conformation | 1992 |
Methylated lysine in storage body protein of sheep with hereditary ceroid-lipofuscinosis.
Topics: Amino Acids; Animals; Brain; Chromatography, Ion Exchange; Chromatography, Thin Layer; Disease Models, Animal; Liver; Lysine; Methylation; Microscopy, Electron; Neuronal Ceroid-Lipofuscinoses; Pancreatin; Proteins; Sheep; Spectrometry, Mass, Fast Atom Bombardment | 1992 |
Further investigations regarding the role of trimethyllysine for cytochrome c uptake into mitochondria.
Topics: Animals; Arginine; Base Sequence; Cloning, Molecular; Codon; Cytochrome c Group; Cytochromes c; Lysine; Methylation; Mitochondria; Mitochondria, Liver; Molecular Sequence Data; Mutagenesis, Site-Directed; Polymerase Chain Reaction; Protein Biosynthesis; Rats; Restriction Mapping; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Structure-Activity Relationship; Transcription, Genetic | 1991 |
A key amino acid determining G3m(b) allotypic markers.
Topics: Amino Acid Sequence; Amino Acids; Chromatography, High Pressure Liquid; Epitopes; Humans; Immunoglobulin Fc Fragments; Immunoglobulin G; Immunoglobulin Gm Allotypes; Lysine; Methylation; Molecular Sequence Data; Protein Conformation; Serine | 1991 |
Involvement of lysine residues 289 and 291 of the cAMP-responsive element-binding protein in the recognition of the cAMP-responsive element.
Topics: Amino Acid Sequence; Animals; Base Sequence; Binding Sites; Cell Line; Cyclic AMP Response Element-Binding Protein; DNA-Binding Proteins; DNA, Neoplasm; Gene Library; Humans; Infant, Newborn; Leucine Zippers; Lysine; Macromolecular Substances; Methylation; Models, Structural; Molecular Sequence Data; Mutagenesis, Site-Directed; PC12 Cells; Polymerase Chain Reaction; Protein Conformation; Restriction Mapping; Sequence Homology, Nucleic Acid | 1991 |
Juvenile ceroid lipofuscinosis. Evidence for methylated lysine in neural storage body protein.
Topics: Adult; Female; Fluorescence; Humans; Lysine; Male; Methylation; Microscopy, Fluorescence; Nerve Tissue Proteins; Neuronal Ceroid-Lipofuscinoses; Reference Values; Retina | 1991 |
Thermodynamics of ligand binding and denaturation for His64 mutants of tissue plasminogen activator kringle-2 domain.
Topics: Binding Sites; Calorimetry; Circular Dichroism; Dialysis; Hydrogen-Ion Concentration; Lysine; Methylation; Models, Molecular; Mutagenesis, Site-Directed; Protein Denaturation; Thermodynamics; Tissue Plasminogen Activator | 1991 |
Multiple ubiquitination of calmodulin results in one polyubiquitin chain linked to calmodulin.
Topics: Amino Acids; Animals; Blotting, Western; Calmodulin; Cattle; Cross-Linking Reagents; Lysine; Male; Methylation; Peptide Synthases; Reticulocytes; Substrate Specificity; Testis; Ubiquitin-Activating Enzymes; Ubiquitin-Protein Ligases; Ubiquitins | 1990 |
IgG rheumatoid factors and staphylococcal protein A bind to a common molecular site on IgG.
Topics: Arthritis, Rheumatoid; Binding Sites, Antibody; Binding, Competitive; Epitopes; Histidine; Humans; Hydrogen-Ion Concentration; Immunoglobulin G; Lysine; Methylation; Protein Conformation; Rheumatoid Factor; Staphylococcal Protein A | 1985 |
Activation energy of sulfate ion transport across methylated human erythrocyte membranes.
Topics: Biological Transport, Active; Borohydrides; Erythrocyte Membrane; Formaldehyde; Humans; Ion Channels; Lysine; Methylation; Sulfates; Temperature | 1988 |
In vivo mutations of calmodulin: a mutant Paramecium with altered ion current regulation has an isoleucine-to-threonine change at residue 136 and an altered methylation state at lysine residue 115.
Topics: Amino Acid Sequence; Animals; Calmodulin; Enzyme Activation; Ion Channels; Isoleucine; Kinetics; Lysine; Methylation; Molecular Sequence Data; Mutation; Myosin-Light-Chain Kinase; Paramecium; Threonine | 1989 |
Comparison of the Fc fragment from a human IgG1 and its CH2, pFc', and tFc' subfragments. A study using reductive methylation and 13C NMR.
Topics: Humans; Immunoglobulin Constant Regions; Immunoglobulin Fc Fragments; Immunoglobulin Fragments; Immunoglobulin G; Lysine; Magnetic Resonance Spectroscopy; Methylation; Oxidation-Reduction | 1989 |
Role of lysine methylation in the activities of elongation factor 1 alpha.
Topics: Amino Acyl-tRNA Synthetases; Kinetics; Lysine; Methylation; Mucor; Peptide Elongation Factor 1; Peptide Elongation Factors; Ribonucleoproteins; RNA, Transfer, Phe; Saccharomyces cerevisiae; Spores, Fungal | 1989 |
13C NMR of methylated lysines of fd gene 5 protein: evidence for a conformational change involving lysine 24 upon binding of a negatively charged lanthanide chelate.
Topics: Bacteriophages; Binding, Competitive; Chelating Agents; Computer Simulation; DNA-Binding Proteins; DNA, Viral; Lanthanum; Lysine; Magnetic Resonance Spectroscopy; Methylation; Models, Molecular; Oligonucleotide Probes; Protein Conformation; Viral Proteins | 1989 |
Importance of amino acids on vasopressin-stimulated water flow.
Topics: Amino Acids; Animals; Bufonidae; Cyclic AMP; Diuresis; Drug Synergism; Female; Glutamates; Glutamic Acid; Histidine; Lysine; Methylation; Structure-Activity Relationship; Theophylline; Urinary Bladder; Vasopressins; Zinc | 1985 |
Involvement of lysine residues in the binding of hGH and bGH to somatotropic receptors.
Topics: Amino Acid Sequence; Animals; Cattle; Female; Growth Hormone; Humans; Liver; Lysine; Methylation; Pregnancy; Rabbits; Radioligand Assay; Receptors, Cell Surface; Receptors, Somatotropin; Species Specificity; Structure-Activity Relationship | 1985 |
Involvement of lysine residues in the binding of ovine prolactin and human growth hormone to lactogenic receptors.
Topics: Acetaldehyde; Animals; Borohydrides; Chemical Phenomena; Chemistry; Female; Formaldehyde; Growth Hormone; Guanidines; Imidoesters; Lysine; Methylation; Prolactin; Rabbits; Radioligand Assay; Receptors, Cell Surface; Receptors, Prolactin; Structure-Activity Relationship | 1985 |
Trimethyllysine and protein function. Effect of methylation and mutagenesis of lysine 115 of calmodulin on NAD kinase activation.
Topics: Amino Acid Sequence; Calmodulin; Chlamydomonas; Dictyostelium; Enzyme Activation; Genes, Synthetic; Lysine; Methylation; Methyltransferases; Phosphotransferases; Phosphotransferases (Alcohol Group Acceptor); Protein Processing, Post-Translational; Recombinant Proteins | 1986 |
Specific chemical modifications of link protein and their effect on binding to hyaluronate and cartilage proteoglycan.
Topics: Acetylation; Animals; Arginine; Cartilage, Articular; Cattle; Chromatography, Gel; Diethyl Pyrocarbonate; Extracellular Matrix Proteins; Female; Histidine; Hyaluronic Acid; Imidazoles; Lysine; Male; Methylation; Proteins; Proteoglycans; Tryptophan; Tyrosine | 1986 |
Effect of exogenous histone H5 on integration of histone H1 in rat liver chromatin. Correlations with aberrant epsilon-N-methylation of histone H1.
Topics: Animals; Binding Sites; Chickens; Chromatin; Histones; Liver; Lysine; Methylation; Methyltransferases; Nucleosomes; Polylysine; Rats; S-Adenosylmethionine; Salmine | 1986 |
The role of Lys 394 in microtubule assembly.
Topics: Amino Acids; Animals; Brain; Cattle; Cyanogen Bromide; Ethyldimethylaminopropyl Carbodiimide; Kinetics; Lysine; Methylation; Microtubule-Associated Proteins; Microtubules; Models, Molecular; Peptide Fragments; Protein Conformation | 1986 |
Changes of lysine reactivities of actin in complex with DNAase I.
Topics: Actins; Deoxyribonuclease I; Electrophoresis, Polyacrylamide Gel; Lysine; Methylation; Oxidation-Reduction; Protein Binding | 1986 |
Lysine-containing DNA-binding regions on the surface of the histone octamer in the nucleosome core particle.
Topics: Amino Acids; Animals; Binding Sites; Chickens; Chromatography, High Pressure Liquid; DNA-Binding Proteins; Histones; Lysine; Methylation; Nucleosomes; Oxidation-Reduction; Peptide Mapping; Trypsin | 1986 |
Thin-layer chromatography of some methylated amino acids with aqueous salt solutions used as eluents.
Topics: Acetates; Acetic Acid; Amino Acids; Chemical Phenomena; Chemistry, Physical; Chromatography, Thin Layer; Lysine; Methylation; Sodium Chloride; Solutions | 1986 |
Methylation in vivo of elongation factor EF-Tu at lysine-56 decreases the rate of tRNA-dependent GTP hydrolysis.
Topics: Escherichia coli; Ethylmaleimide; Guanosine Diphosphate; Guanosine Triphosphate; Hydrolysis; Kinetics; Lysine; Methylation; Peptide Elongation Factor Tu; RNA, Transfer | 1986 |
Purification and properties of calmodulin-lysine N-methyltransferase from rat brain cytosol.
Topics: Animals; Brain; Calmodulin; Chemical Precipitation; Chromatography; Chromatography, High Pressure Liquid; Cytosol; Electrophoresis, Polyacrylamide Gel; Lysine; Methylation; Methyltransferases; Molecular Weight; Octopodiformes; Rats; Rats, Inbred Strains; Substrate Specificity | 1987 |
O6-methylguanine-DNA methyltransferase and alkylation of liver DNA in mice exposed to dimethylnitrosamine during dietary deficiency of essential amino acids.
Topics: Amino Acids; Animals; Cysteine; Diet; Dimethylnitrosamine; DNA; DNA Damage; DNA Repair; Liver; Lysine; Methionine; Methylation; Methyltransferases; Mice; O(6)-Methylguanine-DNA Methyltransferase | 1987 |
Characterization of the chicken oocyte receptor for low and very low density lipoproteins.
Topics: Animals; Apolipoproteins B; Binding, Competitive; Cattle; Chickens; Edetic Acid; Glucosides; Humans; Lipoproteins, HDL; Lysine; Methylation; Molecular Weight; Oocytes; Pronase; Receptors, LDL; Solubility; Suramin | 1987 |
Reductive methylation of lysine residues in acidic fibroblast growth factor: effect on mitogenic activity and heparin affinity.
Topics: Amino Acid Sequence; Animals; Borohydrides; Brain; Cattle; Cell Division; Cells, Cultured; Fibroblast Growth Factors; Formaldehyde; Heparin; Hydroxylamine; Hydroxylamines; Indicators and Reagents; Lysine; Methylation; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Peptide Mapping | 1988 |
Methylation of Drosophila histones at proline, lysine, and arginine residues during heat shock.
Topics: Amino Acids; Animals; Arginine; Arsenic; Arsenites; Cell Line; Drosophila; Histones; Hot Temperature; Lysine; Methylation; Proline; Sodium Compounds | 1988 |
Site-specific methylation of a strategic lysyl residue in aspartate aminotransferase.
Topics: Amino Acid Sequence; Animals; Aspartate Aminotransferases; Circular Dichroism; Isoenzymes; Lysine; Methylation; Myocardium; Oxidation-Reduction; Peptide Fragments; Peptide Mapping; Protein Conformation; Swine; Trypsin | 1988 |
Modification of calmodulin on Lys-75 by carbamoylating nitrosoureas.
Topics: Amino Acid Sequence; Animals; Binding Sites; Calcium; Calmodulin; Carbamates; Cattle; Hydrogen-Ion Concentration; Imidazoles; Lomustine; Lysine; Methylation; Nitrosourea Compounds; Trypsin | 1988 |
Determination of methylated amino acids in human serum by high-performance liquid chromatography.
Topics: Amino Acids; Chromatography, High Pressure Liquid; Humans; Hyperthyroidism; Lysine; Methylation; o-Phthalaldehyde | 1988 |
A 13C NMR characterization of lysine residues in apolipoprotein B and their role in binding to the low density lipoprotein receptor.
Topics: Apolipoprotein B-100; Apolipoproteins B; Chemical Phenomena; Chemistry; Circular Dichroism; Electrophoresis, Polyacrylamide Gel; Ferricyanides; Formaldehyde; Humans; Hydrogen-Ion Concentration; Lipoproteins, LDL; Lysine; Magnetic Resonance Spectroscopy; Methylation; Peptide Fragments; Receptors, LDL; Structure-Activity Relationship; Thrombin | 1988 |
Reductive methylation and 13C NMR studies of the lysyl residues of fd gene 5 protein. Lysines 24, 46, and 69 may be involved in nucleic acid binding.
Topics: Amino Acid Sequence; DNA; DNA-Binding Proteins; Hydrogen-Ion Concentration; Lysine; Magnetic Resonance Spectroscopy; Methylation; Molecular Sequence Data; Peptide Mapping; Viral Proteins | 1988 |
Reductive methylation of lysine residues of botulinum neurotoxin types A and B.
Topics: Animals; Botulinum Toxins; Immunodiffusion; Lethal Dose 50; Lysine; Methylation; Mice; Molecular Weight; Neurotoxins; Oxidation-Reduction; Serotyping; Structure-Activity Relationship | 1988 |
High-affinity association and degradation of 125I-labelled low density lipoproteins by human hepatocytes in primary culture.
Topics: Adult; Cells, Cultured; Fibroblasts; Humans; Lipoproteins, LDL; Liver; Lysine; Methylation; Middle Aged; Receptors, LDL | 1985 |
Accelerated protein turnover in the skeletal muscle of dystrophic mice.
Topics: Actins; Animals; Arginine; Chickens; Lysine; Male; Methylation; Methylhistidines; Mice; Mice, Inbred C57BL; Muscle Proteins; Muscles; Muscular Dystrophy, Animal; Myofibrils; Myosins | 1985 |
Methylation of the active-site lysine of rhodopsin.
Topics: Animals; Binding Sites; Cattle; Formaldehyde; Lysine; Methylation; Photoreceptor Cells; Retinal Pigments; Retinaldehyde; Rhodopsin; Rod Cell Outer Segment; Spectrophotometry | 1985 |
Methylation of basic residues in structural proteins.
Topics: Amino Acids; Arginase; Arginine; Bacterial Proteins; Carboxy-Lyases; Escherichia coli; Euglena gracilis; Histidine; Histidine Ammonia-Lyase; Lysine; Methionine; Methylation; Methylhistidines; Plant Proteins; Protein Conformation; Ribosomes | 1973 |
Chromatography of transforming deoxyribonucleic acid on methylated albumin and by gel filtration.
Topics: Adenine; Albumins; Bacillus subtilis; Centrifugation, Density Gradient; Chromatography; Chromatography, Gel; DNA, Bacterial; Histidine; Lysine; Methylation; Molecular Weight; Temperature; Transformation, Genetic; Ultrafiltration | 1974 |
Epsilon-N-methyl lysine in myosin.
Topics: Adenosine Triphosphatases; Animals; Chromatography; Lysine; Methylation; Muscle Proteins; Rabbits | 1969 |
Role of lysine and -N-trimethyllysine in carnitine biosynthesis. I. Studies in Neurospora crassa.
Topics: Betaine; Butyrates; Carbon Isotopes; Carnitine; Chromatography, Ion Exchange; Culture Media; Hydroxylation; Lysine; Methane; Methionine; Methylation; Models, Chemical; Mutation; Neurospora; Neurospora crassa; Nitrogen Isotopes; Structure-Activity Relationship; Tritium | 1973 |
[Effect of a prolonged treatment by S-carboxy-methyl-cysteine on the disturbances of the pulmonary protein synthesis induced by sulfur dioxide in the rat].
Topics: Administration, Oral; Animals; Carbon Radioisotopes; Carboxylic Acids; Cysteine; Lung; Lysine; Methylation; Mucus; Protein Biosynthesis; Rats; Respiratory System; Sulfur Dioxide; Trachea | 1974 |
Comparison of the morphology, fermentation, assimilation, lipid content and mannans of rough and smooth strains of Saccharomyces cerevisiae.
Topics: Fermentation; Genetics, Microbial; Glycosides; Lipids; Lysine; Methylation; Periodic Acid; Polysaccharides; Saccharomyces | 1971 |
Association of polypeptides with ribonucleic acid. I. Effect of charge of the polypeptide and immune status of animals.
Topics: Alanine; Animals; Antigens; Ascitic Fluid; Bone Marrow; Bone Marrow Cells; Carbon Isotopes; Cattle; Centrifugation, Density Gradient; Chromatography; Female; Glutamates; Iodine Isotopes; Lymph Nodes; Lysine; Macrophages; Male; Methylation; Molecular Weight; Peptides; Rabbits; RNA; Serum Albumin, Bovine; Silicon Dioxide; Spleen; Testis; Tyrosine | 1971 |
Uptake of label into methylated amino acids from rat tissue histones after in vivo administration of (Me- 14 C)methionine.
Topics: Amino Acids; Animals; Arginine; Carbon Isotopes; Carcinoma, Hepatocellular; Chromatography; Histidine; Histones; Liver; Liver Neoplasms; Lysine; Male; Methionine; Methylation; Neoplasms, Experimental; Rats; Thymus Gland; Time Factors | 1971 |
The effects of NaCl on the amino acid acceptor activity of rat liver tRNA.
Topics: Acylation; Amino Acyl-tRNA Synthetases; Animals; Carbon Isotopes; Chromatography; Chromatography, DEAE-Cellulose; Kinetics; Leucine; Liver; Lysine; Male; Methylation; Phenylalanine; Phosphates; Rats; Rats, Inbred Strains; RNA, Transfer; Serum Albumin; Silicon Dioxide; Sodium; Sodium Chloride; Tritium; Valine | 1971 |
Isolation of a lysine transfer ribonucleic acid species from Bacillus subtilis by use of chemical modification.
Topics: Acylation; Bacillus subtilis; Benzoates; Chromatography; Chromatography, DEAE-Cellulose; Iodine; Lysine; Methods; Methylation; Oxidation-Reduction; RNA, Bacterial; RNA, Transfer; Serum Albumin; Silicon Dioxide; Sulfites; Tritium | 1972 |
In vivo turnover and distribution of radio-N-methyl in arginine-rich histones from rat tissues.
Topics: Animals; Arginine; Carbon Isotopes; Carcinoma, Hepatocellular; Chromatography, Ion Exchange; Histones; Kinetics; Liver; Liver Neoplasms; Lysine; Male; Methionine; Methylation; Neoplasms, Experimental; Rats; Spleen | 1972 |
Affinity labeling of Escherichia coli B deoxyribonucleic acid dependent ribonucleic acid polymerase.
Topics: Aldehydes; Binding Sites; Chromatography, Paper; Chromatography, Thin Layer; DNA-Directed RNA Polymerases; Electrophoresis, Disc; Escherichia coli; Inosine; Lysine; Macromolecular Substances; Methylation; Oxidation-Reduction; Periodic Acid; Pronase; Protein Binding; Protein Denaturation; Sulfides; Sulfur; Sulfur Isotopes; Tritium; Urea | 1972 |
Structure and activity of methylated horse liver alcohol dehydrogenase.
Topics: Alcohol Oxidoreductases; Amino Acids; Animals; Borohydrides; Chemical Phenomena; Chemistry; Chromatography, Gel; Drug Stability; Electrophoresis, Polyacrylamide Gel; Formaldehyde; Horses; Hot Temperature; Liver; Lysine; Methylation; NAD; Optical Rotatory Dispersion; Protein Conformation; Sodium; Sodium Dodecyl Sulfate; Spectrophotometry, Ultraviolet; Structure-Activity Relationship; Sulfhydryl Reagents; Ultracentrifugation | 1974 |
Effects of carcinogens and other agents on histone methylation in rat liver nuclei by endogenous histone lysine methyltransferase.
Topics: Adenosine; Animals; Azo Compounds; Benz(a)Anthracenes; Carbon Radioisotopes; Carcinogens; Cell Nucleus; Dimethylformamide; Ethionine; Fluorenes; Histones; Homocysteine; Liver; Lysine; Mesylates; Methylation; Methyltransferases; Nitrosamines; Nitrosoguanidines; Nitrosourea Compounds; Pyrimidines; Pyrroles; Rats; Ribonucleosides; S-Adenosylmethionine | 1974 |
The carbohydrate moiety of sea cucumber (Thyone briareus) gelatin.
Topics: Animals; Binding Sites; Carbohydrates; Chromatography; Chromatography, Gas; Chromatography, Gel; Collagen; Dinitrophenols; Echinodermata; Electrophoresis, Paper; Galactose; Gelatin; Glucose; Glycopeptides; Hydrogen-Ion Concentration; Hydrolysis; Lysine; Methylation; Oxidation-Reduction; Periodic Acid; Pronase; Protein Binding; Spectrophotometry; Temperature; Time Factors; Trypsin | 1972 |
Tritium labeling of luteinizing hormone by reductive methylation.
Topics: Amino Acids; Animals; Biological Assay; Borohydrides; Cattle; Cyclic AMP; Female; Injections, Intravenous; Isotope Labeling; Kinetics; Luteinizing Hormone; Lysine; Male; Methylation; Oxidation-Reduction; Rats; Sheep; Testis; Testosterone; Time Factors; Tritium | 1974 |
Neurophysin methylation in extracts of bovine posterior pituitary gland: hormone binding ability.
Topics: Animals; Binding Sites; Carbon Radioisotopes; Cattle; Chromatography, Affinity; Chromatography, Gel; Electrophoresis, Polyacrylamide Gel; Hydrogen-Ion Concentration; Kinetics; Lysine; Methylation; Molecular Weight; Neurophysins; Pituitary Gland, Posterior; Protein Binding; Receptors, Cell Surface; S-Adenosylmethionine; Vasopressins | 1974 |
In vivo methylation and turnover of rat brain histones.
Topics: Aging; Amino Acids; Animals; Animals, Newborn; Brain; Brain Chemistry; Carbon Radioisotopes; Cell Nucleus; Chromatography, Gel; Chromatography, Ion Exchange; Cytosol; Electrophoresis, Polyacrylamide Gel; Half-Life; Histones; Lysine; Male; Methionine; Methylation; Microsomes; Mitochondria; Nerve Tissue Proteins; Rats; Regression Analysis; Time Factors; Tritium | 1974 |
The effect of epsilon-N-DL-trimethyl-lysine on human lymphocyte cultures.
Topics: Antibody Formation; Autoradiography; Cells, Cultured; DNA; Humans; In Vitro Techniques; Lectins; Lymphocyte Activation; Lymphocytes; Lysine; Methylation; Microscopy, Electron; Stimulation, Chemical | 1974 |
Localization of chromatin proteins within DNA grooves by methylation of chromatin with dimethyl sulphate.
Topics: Animals; Binding Sites; Cattle; Chromatin; Chromatography, Ion Exchange; Coliphages; Dactinomycin; DNA; DNA Viruses; DNA, Single-Stranded; DNA, Viral; Histones; Kinetics; Lysine; Male; Methylation; Molecular Weight; Nucleic Acid Conformation; Nucleic Acid Denaturation; Nucleoproteins; Peptides; Protamines; Protein Binding; Protein Conformation; Salmon; Spectrophotometry, Ultraviolet; Spermatozoa; Sulfuric Acids; Thymus Gland; Tritium; Urea | 1974 |
Bovine erythrocyte superoxide dismutase. Isolation and characterization of tryptic, cyanogen bromide, and maleylated tryptic peptides.
Topics: Amino Acid Sequence; Amino Acids; Animals; Binding Sites; Cattle; Chromatography, DEAE-Cellulose; Chromatography, Gel; Chromatography, Ion Exchange; Chromatography, Paper; Chymotrypsin; Cyanogen Bromide; Electrophoresis, Paper; Erythrocytes; Hydrogen-Ion Concentration; Hydrolysis; Lysine; Macromolecular Substances; Maleates; Methylation; Peptide Fragments; Protein Binding; Solubility; Spectrophotometry, Ultraviolet; Superoxide Dismutase; Trypsin | 1974 |
Developmental changes of the primary structure and histidine methylation in rabbit skeletal muscle myosin.
Topics: Age Factors; Amino Acid Sequence; Amino Acids; Animals; Animals, Newborn; Autoanalysis; Chromatography, Ion Exchange; Electrophoresis, Paper; Histidine; Lysine; Methylation; Methylhistidines; Muscles; Myocardium; Myosins; Peptides; Rabbits | 1972 |
50-S ribosomal proteins. Peptide studies on two acidic proteins, A 1 and A 2 , isolated from 50-S ribosomes of Escherichia coli.
Topics: Amino Acid Sequence; Autoanalysis; Bacterial Proteins; Chromatography, Paper; Electrophoresis, Paper; Escherichia coli; Lysine; Methylation; Molecular Weight; Peptides; Protein Denaturation; Ribosomes; Trypsin | 1972 |
Amino acid sequences around the two -N-trimethyllysine residues in rabbit skeletal muscle myosin.
Topics: Amino Acid Sequence; Amino Acids; Animals; Chemical Phenomena; Chemistry; Chromatography, Gel; Chromatography, Ion Exchange; Electrophoresis, Paper; Hydrogen-Ion Concentration; Lysine; Methylation; Muscle Proteins; Myosin Subfragments; Myosins; Peptides; Rabbits; Spectrophotometry; Thermolysin; Trypsin | 1972 |
Reductive methylation: a method for preparing functionally active radioactive ribosomes.
Topics: Autoradiography; Bacterial Proteins; Borohydrides; Escherichia coli; Formaldehyde; Isotope Labeling; Lysine; Methylation; Ribosomes; Tritium | 1973 |
Function of N2 methylguanine in phenylalanine transfer RNA.
Topics: Alanine; Amino Acyl-tRNA Synthetases; Animals; Base Sequence; Binding Sites; Escherichia coli; Guanine; In Vitro Techniques; Isoleucine; Kinetics; Liver; Lysine; Methionine; Methylation; Nucleic Acid Conformation; Phenylalanine; Rabbits; RNA, Transfer; S-Adenosylmethionine; Saccharomyces cerevisiae; Triticum; tRNA Methyltransferases; Valine | 1973 |
Reductive-methylation studies on L7 and L12 ribosomal proteins.
Topics: Acetylation; Acylation; Amino Acid Sequence; Autoanalysis; Bacterial Proteins; Binding Sites; Borohydrides; Carbon Radioisotopes; Centrifugation, Zonal; Chromatography; Electrophoresis; Escherichia coli; Formaldehyde; Guanosine Triphosphate; Isoelectric Focusing; Lysine; Macromolecular Substances; Methylation; Muramidase; Nucleotidases; Peptide Elongation Factors; Peptide Fragments; Ribosomes; Serine; Trypsin | 1974 |
Methionine-dependent synthesis of ribosomal ribonucleic acid during sporulation and vegetative growth of Saccharomyces cerevisiae.
Topics: Adenine; Carbon Radioisotopes; Cycloheximide; Diploidy; Electrophoresis, Polyacrylamide Gel; Fungal Proteins; Kinetics; Leucine; Lysine; Methionine; Methylation; Phosphorus Radioisotopes; RNA; RNA, Ribosomal; Saccharomyces cerevisiae; Spores, Fungal; Tritium | 1974 |
Methylation of ribosomal proteins in Escherichia coli.
Topics: Amino Acids; Autoanalysis; Bacterial Proteins; Carbon Radioisotopes; Culture Media; Electrophoresis, Paper; Escherichia coli; Lysine; Methionine; Methylation; Ribosomes; Tritium | 1974 |
Inactivation of papain by S-methylation of its cysteinyl residue with O-methylisourea.
Topics: Binding Sites; Chemical Phenomena; Chemistry; Cysteine; Edetic Acid; Enzyme Activation; Hydrogen-Ion Concentration; Kinetics; Lysine; Mathematics; Mercaptoethanol; Mercury; Methylation; Methylurea Compounds; Organometallic Compounds; Papain; Sulfhydryl Reagents; Urea | 1972 |
[N epsilon-methylated lysine: degradation and excretion].
Topics: Animals; Creatinine; Dogs; Europe; Humans; Inulin; Japan; Lysine; Methylation; Mice; Tritium | 1972 |
The molecular requirements for chemotactic attraction of leucocytes by proteins. Studies of proteins with synthetic side groups.
Topics: Acylation; Aldehydes; Alkylation; Amides; Anhydrides; Chemotaxis; Ethers, Cyclic; Fluoresceins; Gelatin; Glutamates; Guanidines; Humans; Immunoglobulin G; Iodoacetates; Leukocytes; Lysine; Methylation; Muramidase; Ovalbumin; Picryl Chloride; Serum Albumin; Tosyl Compounds | 1972 |
[Relative stability of lysine-bound methyl groups in arginie-rich histones and their subfrations in Ehrlich ascites tumor cells in vitro].
Topics: Animals; Arginine; Binding Sites; Carcinoma, Ehrlich Tumor; Cells, Cultured; Electrophoresis; Female; Histones; In Vitro Techniques; Lysine; Methionine; Methylation; Mice; Tritium | 1972 |
[Improved column chromatographic determination of N methylated lysine in physiological solutions].
Topics: Chromatography; Lysine; Methods; Methylation | 1973 |
Protein methylation by cerebral tissue.
Topics: Acetone; Amino Acids; Ammonium Sulfate; Animals; Arginine; Brain; Carbon Isotopes; Cattle; Chromatography, DEAE-Cellulose; Cytoplasm; Dialysis; Histones; Lysine; Methylation; Nerve Tissue Proteins; Powders; Proteins; Rats; S-Adenosylmethionine; Time Factors | 1973 |
The periodic synthesis of S-adenosylmethionine: protein methyltransferases during the HeLa S-3 cell cycle.
Topics: Amino Acids; Arginine; Carbon Isotopes; Cycloheximide; Cytarabine; Dactinomycin; DNA Replication; DNA, Neoplasm; HeLa Cells; Histones; Humans; Kinetics; Lysine; Methionine; Methylation; Methyltransferases; Mitosis; Neoplasm Proteins; S-Adenosylmethionine; Thymidine | 1973 |
Regulation of amino acid transport in chick embryo heart cells. 3. Formal identification of the A mediation as an adaptive transport system.
Topics: Alanine; Amino Acids; Aminoisobutyric Acids; Animals; Biological Transport, Active; Carbon Isotopes; Carboxylic Acids; Cell Membrane; Chick Embryo; Glycine; Heart; In Vitro Techniques; Kinetics; Leucine; Lysine; Methylation; Myocardium; Phenylalanine; Serine; Sodium; Time Factors | 1973 |
Pancreas acinar cell regeneration. 13. Histone synthesis and modification.
Topics: Acetates; Acetylation; Animals; Autoradiography; Carbon Radioisotopes; DNA; Electrophoresis, Polyacrylamide Gel; Ethionine; Histones; Isotope Labeling; Lysine; Male; Methionine; Methylation; Pancreas; Phosphates; Phosphorus Radioisotopes; Rats; Regeneration; Spectrophotometry; Tritium | 1973 |
Determination of the dissociation constants of the lysine residues of lysozyme by proton-magnetic-resonance spectroscopy.
Topics: Enzyme Activation; Gadolinium; Hydrogen-Ion Concentration; Lysine; Magnetic Resonance Spectroscopy; Methylation; Muramidase; Protein Conformation; Protein Denaturation | 1973 |
Quantitative determination of N epsilon-methylated lysines in human plasma and urine.
Topics: Animals; Autoanalysis; Chickens; Chromatography, Ion Exchange; Humans; Hydroxylysine; Kidney; Lysine; Methylation; Ornithine; Species Specificity; Tritium | 1973 |
Chemical modification of lysine residues in ovine luteinizing hormone. Effect on biological activity.
Topics: Alkylation; Animals; Arginine; Ascorbic Acid; Binding Sites; Biological Assay; Borohydrides; Carbamates; Chromatography, Gel; Citrulline; Cyanogen Bromide; Female; Formaldehyde; Guanidines; Luteinizing Hormone; Lysine; Methylation; Ovary; Oxidation-Reduction; Protein Binding; Protein Conformation; Sheep; Structure-Activity Relationship | 1974 |
Identification of rapidly trinitrophenylating amino groups of human Bence-Jones proteins.
Topics: Amino Acids; Bence Jones Protein; Chemical Phenomena; Chemistry; Chromatography, Gel; Chromatography, Ion Exchange; Chymotrypsin; Electrophoresis; Humans; Lysine; Methylation; Nitrobenzenes; Oxidation-Reduction | 1974 |
Acetylation and methylation of histones in pernicious anemia.
Topics: Acetylation; Amino Acids; Anemia, Pernicious; Bone Marrow Examination; Electrophoresis, Paper; Erythropoiesis; Histones; Humans; Lysine; Methionine; Methylation; Tritium; Vitamin B 12 | 1974 |
[Primary structure of histones (author's transl)].
Topics: Acetylation; Acetyltransferases; Amino Acid Sequence; Animals; Arginine; Chickens; Fishes; Histones; Liver; Lysine; Methylation; Phosphates; Swine; Thymus Gland; Vegetables | 1974 |
Syntheses and conformational studies of poly(N-epsilon-methyl-L-lysine), poly(N-delta-methyl-L-ornithine), poly(N-delta-ethyl-L-ornithine), and their carbobenzoxy derivatives.
Topics: Circular Dichroism; Hydrogen-Ion Concentration; Lysine; Mathematics; Methylation; Optical Rotatory Dispersion; Ornithine; Peptides; Potentiometry; Protein Conformation; Temperature; Thermodynamics | 1974 |
Influence of additional methyl groups in the N-epsilon-amino position of lysine on the renal handling.
Topics: Absorption; Animals; Dogs; Female; Kidney Tubules; Lysine; Male; Methods; Methylation; Tritium | 1974 |
Formaldehyde binding by 2-keto-4-hydroxyglutarate aldolase. Formation and characterization of an inactive aldolase-formaldehyde-cyanide adduct.
Topics: Aldehyde-Lyases; Animals; Binding Sites; Borohydrides; Carbon Radioisotopes; Cattle; Chromatography, DEAE-Cellulose; Chromatography, Paper; Cyanides; Formaldehyde; Glyoxylates; Ketoglutaric Acids; Kinetics; Liver; Lysine; Methylation; Oxidation-Reduction; Protein Binding; Pyruvates | 1974 |
Methylation of protein by calf spleen methylase. A new protein methylation reaction.
Topics: Adenine Nucleotides; Animals; Arginine; Carbon Isotopes; Cattle; Chromatography, Paper; Hot Temperature; Hydrogen-Ion Concentration; Lysine; Methanol; Methionine; Methylation; Ovalbumin; Pepsin A; Proteins; Serum Albumin; Spleen; Transferases | 1969 |
Biosynthesis of 50 s ribosomal subunit in Escherichia coli.
Topics: Amino Acids; Bacterial Proteins; Carbon Isotopes; Centrifugation, Density Gradient; Chloramphenicol; Chlorides; Chromatography, Gel; Escherichia coli; Lithium; Lysine; Methylation; Ribosomes; RNA, Bacterial; Tritium; Uridine | 1969 |
The chemical structure of tryptophanase from Escherichia coli. I. Isolation and structure of a pyridoxyl decapeptide from borohydride-reduced holotryptophanase.
Topics: Amino Acids; Boron Compounds; Chromatography, Ion Exchange; Chromatography, Paper; Chymotrypsin; Electrophoresis; Escherichia coli; Fluorescence; Hydro-Lyases; Indoles; Lysine; Methylation; Oxidation-Reduction; Paper; Peptides; Pyruvates; Spectrophotometry; Tryptophan | 1970 |
Effect of pactamycin on methylation of RNA and protein synthesis.
Topics: Alanine; Anti-Bacterial Agents; Antimetabolites; Bacillus subtilis; Bacterial Proteins; Cell-Free System; Depression, Chemical; Lysine; Methylation; Phenylalanine; Polynucleotides; Ribosomes; RNA, Bacterial; RNA, Transfer; Valine | 1968 |
Transfer RNA patterns in livers of rats fed diets containing 3'-methyl-4-dimethylaminoazobenzene.
Topics: Amino Acids; Animals; Arginine; Carbon Isotopes; Cell Transformation, Neoplastic; Chemical and Drug Induced Liver Injury; Chromatography; Female; Histidine; Leucine; Liver Diseases; Lysine; Methionine; Methylation; p-Dimethylaminoazobenzene; Phenylalanine; Precancerous Conditions; Rats; RNA, Transfer; Serine; Threonine; Tritium; Tyrosine; Valine | 1970 |
Methylation of arginine and lysine residues of cerebral proteins.
Topics: Amino Acids; Animals; Arginine; Bacteria; Brain; Carbon Isotopes; Carboxy-Lyases; Chemical Phenomena; Chemistry; Chromatography, Ion Exchange; Chromatography, Paper; Electrophoresis, Paper; Enterococcus faecalis; Hydrolysis; Isomerism; Liver; Lysine; Methylation; Nerve Tissue Proteins; Proteins; Rats; S-Adenosylmethionine; Ureohydrolases | 1971 |
Induction of interferon in L cells by polyinosinic-polycytidylic acid in the presence of cationic compounds. I. Polycations.
Topics: Adsorption; Carbon Isotopes; Culture Media; Dextrans; Glass; Histones; Interferons; L Cells; Lysine; Methylation; Ornithine; Peptide Hydrolases; Phenylalanine; Poly I-C; Polymers; Polynucleotides; Protamines; Protein Biosynthesis; Ribonucleases; Serum Albumin, Bovine; Sulfates; Tritium | 1972 |
Acanthamoeba actin. Composition of the peptide that contains 3-methylhistidine and a peptide that contains N e -methyllysine.
Topics: Acetamides; Actins; Alkylation; Amino Acids; Amoeba; Animals; Chromatography, DEAE-Cellulose; Chromatography, Gel; Chromatography, Ion Exchange; Cyanogen Bromide; Electrophoresis; Histidine; Iodoacetates; Isotope Labeling; Lysine; Methylation; Methylhistidines; Molecular Weight; Muscle Proteins; Muscles; Oxidation-Reduction; Peptides; Rabbits; Sodium Dodecyl Sulfate; Tritium | 1972 |
Studies of histone methylation during the HeLa S-3 cell cycle.
Topics: Amino Acids; Carbon Isotopes; Cell Fractionation; Cell Nucleus; Chromatography, Ion Exchange; DNA Replication; Electrophoresis; HeLa Cells; Histones; Humans; Hydrogen-Ion Concentration; Lysine; Methionine; Methylation; Methylhistidines; Mitosis; Peptides; Solubility; Thymidine; Time Factors; Tritium | 1972 |
Histone methylation during hepatic regeneration in rat.
Topics: Animals; Arginine; Carbon Isotopes; Cytoplasm; DNA; Hepatectomy; Histones; Kinetics; Liver; Liver Regeneration; Lysine; Male; Methylation; Methyltransferases; Orotic Acid; Proteins; Rats; RNA; S-Adenosylmethionine; Thymidine; Tritium | 1972 |
Protein methylation during the development of rat brain.
Topics: Animals; Animals, Newborn; Arginine; Brain; Carbon Isotopes; Carboxylic Acids; Cytoplasm; Ethanol; Fetus; Histones; Lysine; Methionine; Methylation; Methyltransferases; Nerve Tissue Proteins; Proteins; Rats; S-Adenosylmethionine; Solubility; Sulfuric Acids; Transferases; Tritium | 1972 |
The distribution and turnover of labeled methyl groups in histone fractions of cultured mammalian cells.
Topics: Amino Acids; Animals; Arginine; Carbon Isotopes; Cell Fractionation; Cell Line; Cells, Cultured; Chromatography, Gas; Cricetinae; Half-Life; Histones; Hydrolysis; Lysine; Methionine; Methylation | 1972 |
Effect of methylation on susceptibility of protein to proteolytic enzymes.
Topics: Amines; Animals; Borohydrides; Cattle; Chemical Phenomena; Chemistry; Chymotrypsin; Formaldehyde; Formates; Histones; Hydrolysis; Indenes; Indicators and Reagents; Ketones; Kinetics; Lysine; Methylation; Nitrobenzenes; Oxidation-Reduction; Pancreas; Peptides; Ribonucleases; Sulfonic Acids; Trypsin | 1972 |
Subunits of bakers' yeast cytochrome b2 (L-lactate cytochrome c oxidoreductase). 2. End groups and origin of microheterogeneity.
Topics: Alanine; Carboxypeptidases; Chemical Phenomena; Chemistry; Cytochromes; Fluorides; L-Lactate Dehydrogenase; Lysine; Methylation; Protease Inhibitors; Saccharomyces | 1971 |
Identification of lysines reactive with pyridoxal 5'-phosphate in glyceraldehyde-3-phosphate dehydrogenase.
Topics: Amino Acid Sequence; Animals; Boron Compounds; Electrophoresis; Fluorescence; Glyceraldehyde-3-Phosphate Dehydrogenases; Lysine; Methylation; Muscles; Peptides; Pyridoxal Phosphate; Rabbits | 1971 |
Examination of the tumour growth promoting effect of -N-trimethyllysine. An autoradiographic study.
Topics: Animals; Ascites; Autoradiography; Female; Lymphoma; Lysine; Methylation; Mice; Mitosis; Neoplasms, Experimental; Thymidine; Time Factors; Tritium | 1971 |
Methylation of lysine residues of histone fractions in synchronized mammalian cells.
Topics: Amino Acids; Animals; Cell Division; Cell Line; Chromatography, Paper; Cricetinae; Culture Techniques; DNA; Electrophoresis; Female; Histones; Hydrolysis; Isoleucine; Lysine; Methionine; Methylation; Mitosis; Ovary; Paper; Thymidine; Tritium | 1971 |
A study of chemically methylated deoxyribonucleic acid.
Topics: Adenine; Animals; Binding Sites; Cattle; Circular Dichroism; Dialysis; DNA, Bacterial; Filtration; Guanine; Hot Temperature; Luminescent Measurements; Lysine; Methylation; Protein Denaturation; RNA Nucleotidyltransferases; Spermine; Viscosity | 1971 |
Protein methylation.
Topics: Actins; Amino Acids; Animals; Arginine; Aspartic Acid; Autoanalysis; Carboxylic Acids; Cats; Cattle; Cell Wall; Chromatography, Paper; Cytochromes; Flagella; Glutamates; Histidine; Histones; Humans; Lysine; Methylation; Methyltransferases; Myosins; Ornithine; Ovalbumin; Proteins; Rabbits; Rats; Ribosomes; S-Adenosylmethionine | 1971 |
Histone methylation. Partial purification of two histone-specific methyltransferases from rat thymus nuclei preferentially methylating histones F2a 1 and F3.
Topics: Acetone; Albumins; Amino Acids; Ammonium Sulfate; Animals; Arginine; Cell Nucleus; Chemical Precipitation; Chromatography, DEAE-Cellulose; Chromatography, Gel; Cytochromes; Electrophoresis; Hemoglobins; Histidine; Histones; Hydrogen-Ion Concentration; Kinetics; Lysine; Male; Methylation; Methyltransferases; Molecular Weight; Muramidase; Peptides; Protamines; Rats; Rats, Inbred Strains; Ribonucleases; S-Adenosylmethionine; Thymus Gland; Tritium | 1971 |
The amino-acid sequence of the cytochrome c of Ginkgo biloba L.
Topics: Amino Acid Sequence; Chymotrypsin; Cytochromes; Dansyl Compounds; Lysine; Methods; Methylation; Trees; Trypsin | 1971 |
A modified synthesis of -N-carbobenzoxy-L-lysine and the preparation and analysis of mixtures of -N-methyllysines.
Topics: Aluminum; Benzyl Compounds; Carbonates; Chemical Phenomena; Chemistry; Chromatography; Chromatography, Ion Exchange; Copper; Diazomethane; Formates; Lysine; Methylation; Spectrophotometry | 1971 |
Enzymatic methylation of skeletal muscle contractile proteins.
Topics: Actins; Actomyosin; Animals; Animals, Newborn; Carbon Isotopes; Chick Embryo; Chickens; Chromatography, Gel; Chromatography, Ion Exchange; Histidine; Kinetics; Lysine; Methionine; Methylation; Muscle Proteins; Muscles; Myofibrils; Myosins; S-Adenosylmethionine; Sarcoplasmic Reticulum; Ultracentrifugation | 1971 |
Epsilon-N-dimethyllysine in amoeba actin.
Topics: Amino Acids; Amoeba; Chromatography, Ion Exchange; Lysine; Methylation; Muscle Proteins; Tritium | 1970 |
Methylation of protein (histone) in vitro: enzymic activity from the soluble fraction of rat organs.
Topics: Acyltransferases; Amino Acids; Animals; Arginine; Carbon Isotopes; Cattle; Coenzyme A; Dialysis; Estradiol; Female; Histones; Hot Temperature; Hydrogen-Ion Concentration; Insulin; Kinetics; Lysine; Methionine; Methylation; Nucleosides; Puromycin; Rats; Ribonucleases; Spleen; Thymus Gland; Transferases; Ultracentrifugation; Uterus | 1969 |
The carboxypeptidase B-catalyzed hydrolysis of poly-episilon-N-methyl-L-lysine and poly-episilon-N, episilon-N-dimethyl-L-lysine.
Topics: Amino Acids; Animals; Carboxypeptidases; Kinetics; Lysine; Methylation; Peptides; Swine; Time Factors | 1969 |
Secondary modification of cytochrome c by Neurospora crassa.
Topics: Amino Acids; Carbon Isotopes; Chemical Phenomena; Chemistry; Chromatography, Ion Exchange; Chymotrypsin; Culture Media; Cytochromes; Kinetics; Lysine; Methylation; Mitochondria; Mutation; Neurospora; Peptide Biosynthesis; Peptides; Tritium; Ultracentrifugation | 1969 |
Epsilon-N-monomethyl-lysine and trimethyl-lysine in myosin.
Topics: Animals; Carbon Isotopes; Lysine; Methionine; Methylation; Muscle Proteins; Myofibrils; Protein Biosynthesis; Rabbits | 1970 |
Immunochemical studies on hen's egg-white lysozyme. The role of the lysine, the histidine and the methionine residues.
Topics: Antibodies; Antibody Specificity; Carbamates; Chemical Precipitation; Chromatography, Thin Layer; Cyanides; Female; Histidine; Immune Sera; Immunochemistry; Lysine; Methionine; Methylation; Muramidase; Ovalbumin; Ovum | 1970 |
Isolation and identification of N-G,N-G- and N-G,N'-G-dimethyl-arginine, N-epsilon-mono-, di-, and trimethyllysine, and glucosylgalactosyl- and galactosyl-delta-hydroxylysine from human urine.
Topics: Amino Acids; Arginine; Chromatography, Ion Exchange; Chromatography, Paper; Diet; Galactose; Glycosuria; Humans; Infrared Rays; Lysine; Magnetic Resonance Spectroscopy; Methylation | 1970 |
Effect of N-methylation and chain length on kinetic constants of trypsin substrates. Epsilon-N-methyllysine and homolysine derivatives as substrates.
Topics: Amides; Amino Acids; Arginine; Benzoates; Caprylates; Chemical Phenomena; Chemistry; Chromatography, Thin Layer; Esters; Kinetics; Lysine; Methylation; Ornithine; Peptides; Trypsin; Trypsin Inhibitors | 1970 |
Solubilization and partial purification of protein methylase 3 from calf thymus nuclei.
Topics: Animals; Carbon Isotopes; Cattle; Cell Nucleus; Chromatography, DEAE-Cellulose; Enzymes; Histones; Lysine; Magnesium; Methionine; Methods; Methylation; Nucleosides; Rats; Solubility; Thymus Gland; Transferases; Zinc | 1970 |
S methylation of thiols by O-methylisourea.
Topics: Acetates; Amino Acids; Chemical Phenomena; Chemistry; Cysteine; Deuterium; Dipeptides; Ethanol; Glycine; Guanidines; Hydrogen-Ion Concentration; Imidazoles; Kinetics; Lysine; Magnetic Resonance Spectroscopy; Mathematics; Mercaptoethanol; Methylation; Models, Biological; Sulfhydryl Compounds; Sulfhydryl Reagents; Time Factors; Urea | 1970 |
Calf thymus histone 3: sequences of the amino-and carboxyl-terminal regions and of the regions containing lysyl residues modified by acetylation and methylation.
Topics: Amino Acid Sequence; Amino Acids; Animals; Cattle; Histones; Lysine; Malates; Methylation; Peptides; Thymus Gland; Trypsin | 1970 |
Enzymic modification of chromosomal macromolecules. I. DNA and protein methylation in mouse tumour cell chromatin.
Topics: Amino Acids; Animals; Arginine; Ascitic Fluid; Catalysis; Cell Nucleus; Centrifugation, Density Gradient; Chemical Precipitation; Chromatography; Chromatography, Paper; Chromosomes; Colorimetry; Cytosine; Deoxyribonucleases; DNA, Neoplasm; Drug Stability; Electrophoresis; Histidine; Histones; Hydrogen-Ion Concentration; Hydrolysis; Lysine; Methylation; Methyltransferases; Mice; Neoplasm Proteins; Neoplasms, Experimental; S-Adenosylmethionine; Temperature; Time Factors; Transferases; Tritium | 1971 |
N G ,N G ,-dimethylarginine in myosin during muscle development.
Topics: Actins; Age Factors; Amino Acids; Animals; Animals, Newborn; Arginine; Carbon Isotopes; Cell Line; Chick Embryo; Chromatography, Ion Exchange; Electrophoresis; Hindlimb; Histidine; Hydrolysis; Isomerism; Lysine; Methionine; Methylation; Muscle Development; Muscle Proteins; Muscles; Myocardium; Myosins; Paper; Rats | 1971 |
Purification and specificity of porcine enterokinase.
Topics: Aminopeptidases; Animals; Aspartic Acid; Binding Sites; Calcium; Catalysis; Cattle; Chromatography, DEAE-Cellulose; Chromatography, Gel; Chromatography, Ion Exchange; Chromatography, Paper; Chymotrypsin; Duodenum; Electrophoresis; Endopeptidases; Enzyme Activation; Enzyme Precursors; Hydrogen-Ion Concentration; Hydrolysis; Isoflurophate; Isoleucine; Kinetics; Lysine; Methylation; Paper; Peptides; Phosphorus Isotopes; Protease Inhibitors; Sulfonic Acids; Swine; Toluene; Trypsin; Trypsin Inhibitors; Trypsinogen | 1971 |
The methylation of histones during regeneration of the liver.
Topics: Acetone; Amino Acids; Animals; Arginine; Carbon Isotopes; Cell Division; Cell Nucleus; DNA; Electrophoresis; Histones; Liver; Liver Regeneration; Lysine; Male; Methionine; Methylation; Rats; RNA; Thymidine | 1968 |
[Nepsilon-methylated lysine in histones from chicken erythrocytes].
Topics: Amino Acids; Animals; Cell Nucleus; Chickens; Chromatography; Erythrocytes; Histones; Lysine; Methylation | 1968 |
Epsilon-N-methyl lysine: an additional amino-acid in human plasma.
Topics: Blood Protein Electrophoresis; Chromatography, Paper; Humans; Lysine; Methylation | 1969 |
Calf and pea histone IV. II. The complete amino acid sequence of calf thymus histone IV; presence of epsilon-N-acetyllysine.
Topics: Amino Acid Sequence; Amino Acids; Animals; Binding Sites; Cattle; Chemical Phenomena; Chemistry; Chromatography, Gel; DNA; Histones; Lysine; Maleates; Methylation; Peptides; Plants; Protein Hydrolysates; Thymus Gland | 1969 |
Effects of cycloheximide on ribosomal RNA synthesis in yeast.
Topics: Ascomycota; Carbon Isotopes; Centrifugation, Density Gradient; Cycloheximide; Lysine; Methionine; Methylation; Molecular Weight; Ribosomes; RNA; Stimulation, Chemical; Tritium; Uracil | 1969 |
Specificity of the enzymatic methylation of pea histone.
Topics: Adenine Nucleotides; Electrophoresis; Histones; Lysine; Methionine; Methylation; Plants; Spectrophotometry; Tritium | 1969 |
[Synthesis of tritium-labelled, N-methylated lysine].
Topics: Amino Acids; Bromides; Lysine; Malonates; Methylation; Quaternary Ammonium Compounds; Tritium | 1969 |
[Fractionation and properties of N-methylated lysines].
Topics: Autoanalysis; Carboxy-Lyases; Chemical Phenomena; Chemistry; Chromatography; Chromatography, Paper; Electrophoresis; Hot Temperature; Lysine; Methylation; Pipecolic Acids | 1969 |
The carboxymethylation of human metmyoglobin.
Topics: Amino Acids; Animals; Bromine; Carbon Isotopes; Cetacea; Chemical Phenomena; Chemistry; Electrophoresis; Globins; Guanidines; Histidine; Humans; Hydrogen-Ion Concentration; Imidazoles; Iodoacetates; Lysine; Methionine; Methylation; Myoglobin; Optical Rotatory Dispersion; Peptides; Protein Denaturation; Protein Hydrolysates; Solubility; Time Factors; Trypsin; Urea | 1969 |
Protein methylation in rat brain in vitro.
Topics: Amino Acids; Animals; Arginine; Carbon Isotopes; Centrifugation; Chromatography; Dialysis; Histidine; Histones; In Vitro Techniques; Kidney; Liver; Lysine; Male; Methionine; Methylation; Myocardium; Nerve Tissue Proteins; Pancreas; Rats; Spleen; Testis; Thymus Gland | 1969 |
Chemical studies of histone methylation. Evidence for the occurrence of 3-methylhistidine in avian erythrocyte histone fractions.
Topics: Amino Acids; Anemia; Animals; Autoanalysis; Blood Proteins; Chromatography, Ion Exchange; Ducks; Electrophoresis; Erythrocyte Aging; Erythrocyte Count; Erythrocytes; Histidine; Histones; Hydrogen-Ion Concentration; In Vitro Techniques; Lysine; Methionine; Methylation; Reticulocytes; Time Factors; Tritium | 1969 |
Enzymatic trimethylation of residue-72 lysine in cytochrome c. Effect on the total structure.
Topics: Animals; Asparagine; Chemical Phenomena; Chemistry; Cytochrome c Group; Histone-Lysine N-Methyltransferase; Horses; Hydrogen Bonding; Isoelectric Focusing; Isoelectric Point; Lysine; Methylation; Models, Molecular; Neurospora crassa; Protein Methyltransferases; Saccharomyces cerevisiae; Species Specificity | 1980 |
[13C]Methylated ribonuclease A. 13C NMR studies of the interaction of lysine 41 with active site ligands.
Topics: Animals; Binding Sites; Carbon Isotopes; Cattle; Endonucleases; Hydrogen-Ion Concentration; Kinetics; Lysine; Magnetic Resonance Spectroscopy; Methylation; Pancreas; Ribonuclease, Pancreatic; Ribonucleases | 1981 |
Involvement of basic amino acids in the activity of a nucleic acid helix-destabilizing protein.
Topics: Acylation; Arginine; Circular Dichroism; DNA Helicases; DNA-Binding Proteins; Endonucleases; Kinetics; Lysine; Methylation; Nucleic Acid Conformation; Osmolar Concentration; Phenylglyoxal; Poly dA-dT; Protein Conformation; Ribonuclease, Pancreatic; Ribonucleases; Viral Proteins | 1981 |
Manifold effects of sodium butyrate on nuclear function. Selective and reversible inhibition of phosphorylation of histones H1 and H2A and impaired methylation of lysine and arginine residues in nuclear protein fractions.
Topics: Arginine; Butyrates; Cell Nucleus; HeLa Cells; Histones; Humans; Lysine; Methylation; Nucleoproteins; Phosphoprotein Phosphatases; Phosphorus Radioisotopes; Phosphorylation; Protein Kinases; S-Adenosylmethionine | 1981 |
The site of attachment of retinal in bacteriorhodopsin. The epsilon-amino group in Lys-41 is not required for proton translocation.
Topics: Bacteriorhodopsins; Carotenoids; Chymotrypsin; Kinetics; Lysine; Methylation; Peptide Fragments; Protons; Retinaldehyde; Spectrophotometry; Vitamin A | 1982 |
Enzymatic trimethylation of lysine-72 in cytochrome c.
Topics: Animals; Chemical Phenomena; Chemistry; Cytochrome c Group; Horses; Isoelectric Focusing; Lysine; Methylation; Myocardium; Urea | 1983 |
Critical lysine residue at the chloride binding site of angiotensin converting enzyme.
Topics: Animals; Chlorides; Hydrogen-Ion Concentration; Kinetics; Lung; Lysine; Mathematics; Methylation; Peptidyl-Dipeptidase A; Rabbits | 1983 |
Identification of lysine residues essential for microtubule assembly. Demonstration of enhanced reactivity during reductive methylation.
Topics: Animals; Brain Chemistry; Cattle; Cyanogen Bromide; Kinetics; Lysine; Macromolecular Substances; Mathematics; Methylation; Microtubules; Tubulin | 1983 |
Specific 13C reductive methylation of glycophorin A. Possible relation of the N-terminal amino acid and the lysine residues to MN blood group specificities.
Topics: Amino Acid Sequence; Animals; Carbon Isotopes; Chemical Phenomena; Chemistry; Glycophorins; Humans; Lysine; Magnetic Resonance Spectroscopy; Methylation; MNSs Blood-Group System; Oxidation-Reduction; Rabbits; Sialoglycoproteins | 1983 |
Analysis for methylated amino acids in proteins.
Topics: Amino Acids; Animals; Histidine; Lysine; Methods; Methylation; Molecular Weight; Proteins | 1983 |
Reductive methylation of insulin. Production of a biologically active tritiated insulin.
Topics: Glycine; Insulin; Isoelectric Point; Lysine; Methylation; Oxidation-Reduction; Structure-Activity Relationship; Time Factors; Tritium | 1983 |
Spontaneous N epsilon-methylation and N epsilon-formylation reactions between L-lysine and formaldehyde inhibited by L-ascorbic acid.
Topics: Ascorbic Acid; Chemical Phenomena; Chemistry; Formaldehyde; Lysine; Magnetic Resonance Spectroscopy; Methylation | 1983 |
Arsenite-induced changes in methylation of the 70,000 dalton heat shock proteins in chicken embryo fibroblasts.
Topics: Amino Acids; Animals; Arginine; Arsenic; Arsenites; Chick Embryo; Fibroblasts; Heat-Shock Proteins; Kinetics; Lysine; Methylation | 1984 |
Pyridine borane as a reducing agent for proteins.
Topics: Alkylation; Amino Acids; Boranes; Boron Compounds; Carbohydrates; Chemical Phenomena; Chemistry; Indicators and Reagents; Lysine; Methylation; Oxidation-Reduction; Proteins; Pyridines; Serum Albumin, Bovine; Trifluoroacetic Acid; Tryptophan | 1984 |
Amine inversion in proteins. A 13C-NMR study of proton exchange and nitrogen inversion rates in N epsilon,N epsilon,N alpha,N alpha-[13C]tetramethyllysine,N epsilon,N epsilon,N alpha,N alpha-[13C]tetramethyllysine methyl ester, and reductively methylated
Topics: Concanavalin A; Hydrogen-Ion Concentration; Kinetics; Lysine; Magnetic Resonance Spectroscopy; Mathematics; Methylation | 1984 |
Methyl motions in 13C-methylated concanavalin as studied by 13C magnetic resonance relaxation techniques.
Topics: Alanine; Concanavalin A; Lysine; Magnetic Resonance Spectroscopy; Methylation | 1984 |
Carnitine biosynthesis from gamma-butyrobetaine and from exogenous protein-bound 6-N-trimethyl-L-lysine by the perfused guinea pig liver. Effect of ascorbate deficiency on the in situ activity of gamma-butyrobetaine hydroxylase.
Topics: Animals; Ascorbic Acid Deficiency; Betaine; Carbon Radioisotopes; Carnitine; gamma-Butyrobetaine Dioxygenase; Guinea Pigs; Liver; Lysine; Male; Methylation; Mixed Function Oxygenases; Orosomucoid; Perfusion; Tissue Distribution; Tritium | 1984 |
A simple analysis of methylated proteins.
Topics: Animals; Carbon Radioisotopes; Escherichia coli; HeLa Cells; Humans; Lysine; Methionine; Methylation; Neoplasm Proteins; Protein Processing, Post-Translational; Proteins; Radioisotope Dilution Technique; Ribosomal Proteins; Tritium | 1984 |
Methylated lysines and 3-methylhistidine in myosin: tissue and developmental differences.
Topics: Amino Acid Sequence; Amino Acids; Animals; Chick Embryo; Histidine; Lysine; Methylation; Methylhistidines; Muscles; Myocardium; Myosins; Plants; Polyribosomes; Rabbits; Radioisotope Dilution Technique; S-Adenosylmethionine; Triticum; Tritium | 1984 |
Immunogenicity of homologous low density lipoprotein after methylation, ethylation, acetylation, or carbamylation: generation of antibodies specific for derivatized lysine.
Topics: Acetylation; Albumins; Alkylation; Animals; Antibodies; Antibody Formation; Antibody Specificity; Binding, Competitive; Chemical Phenomena; Chemistry; Guinea Pigs; Immune Sera; Immunization; Lipoproteins, LDL; Lysine; Methylation | 1984 |
Reductive methylation of the lysyl residues in the fd gene 5 DNA-binding protein: CD and 13C NMR results on the modified protein.
Topics: Binding Sites; Circular Dichroism; DNA-Binding Proteins; Lysine; Magnetic Resonance Spectroscopy; Methylation; Oligodeoxyribonucleotides; Oxidation-Reduction; Viral Proteins | 1984 |
Inhibition of receptor-mediated clearance of lysine and arginine-modified lipoproteins from the plasma of rats and monkeys.
Topics: Animals; Arginine; Cyclohexanones; Haplorhini; Kupffer Cells; Lipoproteins, LDL; Lysine; Macaca mulatta; Metabolic Clearance Rate; Methylation; Rats; Receptors, Drug | 1980 |
Spontaneous N epsilon-methylation of L-lysine by formaldehyde.
Topics: Chemical Phenomena; Chemistry; Chromatography, Thin Layer; Formaldehyde; Lysine; Magnetic Resonance Spectroscopy; Methylation; Models, Biological | 1980 |
Methylation-like reaction of [3H-methyl]-N-5-trimethyllysine (TML) to chromatin components.
Topics: Animals; Chromatin; DNA; Lysine; Methylation; Mice; Molecular Weight; Neoplasms, Experimental | 1980 |
Alteration of methylation patterns in rat liver histones following administration of ethionine, a liver carcinogen.
Topics: Animals; Arginine; Cell Nucleus; Ethionine; Histone-Lysine N-Methyltransferase; Histones; Liver; Lysine; Male; Methionine; Methylation; Protein-Arginine N-Methyltransferases; Rats | 1981 |
Analysis of radiomethylated N epsilon-methyllysines and other methylated amino acids by ion-exchange chromatography with fluorescent detection.
Topics: Amino Acids; Chromatography, Ion Exchange; Liver; Lysine; Methylation; Spectrometry, Fluorescence | 1981 |
A modification of alpha-bungarotoxin amino group residues with retention of binding properties to isolated and membrane-bound acetylcholine receptor.
Topics: Animals; Bungarotoxins; Cell Membrane; Chemical Phenomena; Chemistry; Fishes; In Vitro Techniques; Lysine; Methylation; Receptors, Cholinergic; Structure-Activity Relationship | 1981 |
Quantitation of methylated basic amino acids in biological fluid.
Topics: Adult; Amino Acids; Arginine; Autoanalysis; Chromatography, Ion Exchange; Humans; Lysine; Methylation | 1981 |
Effects of protein modification procedures on the interaction between 25-hydroxyvitamin D and the human plasma binding protein for vitamin D and its metabolites.
Topics: 25-Hydroxyvitamin D 2; Arginine; Carrier Proteins; Ergocalciferols; Guanidine; Guanidines; Humans; Lysine; Methylation; Spectrophotometry, Ultraviolet; Structure-Activity Relationship; Vitamin D; Vitamin D-Binding Protein | 1981 |
Reduced immunoregulatory potency of low density lipoproteins with selectively modified arginine and lysine residues of apolipoprotein B.
Topics: Amino Acids; Apolipoproteins; Apolipoproteins B; Arginine; Borohydrides; Cyclohexanones; Humans; Immunosuppression Therapy; Iodides; Lipoproteins, LDL; Lymphocyte Activation; Lymphocytes; Lysine; Methylation; Spectrometry, Fluorescence | 1981 |
An efficient method for in vitro labeling proteins to high specific radioactivity using 3H-NaBH4 in dimethylformamide.
Topics: Borohydrides; Dimethylformamide; Lysine; Methylation; Proteins; Radioisotope Dilution Technique; Serum Albumin, Bovine; Tritium | 1981 |
Reductive methylation of the two 4,4'-diisothiocyanodihydrostilbene-2,2'-disulfonate-binding lysine residues of band 3, the human erythrocyte anion transport protein.
Topics: 4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; 4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; Anion Exchange Protein 1, Erythrocyte; Binding Sites; Blood Proteins; Electrophoresis, Polyacrylamide Gel; Humans; Lysine; Methylation; Peptide Fragments; Protein Binding; Stilbenes | 1982 |
Methylation of chicken fibroblast heat shock proteins at lysyl and arginyl residues.
Topics: Animals; Arginine; Cells, Cultured; Chick Embryo; Drug Stability; Fibroblasts; Heat-Shock Proteins; Hot Temperature; Lysine; Methionine; Methylation; Molecular Weight; Proteins | 1982 |
Methylation of elongation factor 1 alpha from the fungus Mucor.
Topics: Amino Acids; Fungal Proteins; Lysine; Macromolecular Substances; Methylation; Morphogenesis; Mucor; Peptide Elongation Factor 1; Peptide Elongation Factors; Peptide Fragments | 1982 |
Abnormal myosin heavy chain variant associated with avian muscular dystrophy.
Topics: Amino Acid Sequence; Animals; Gene Expression Regulation; Histidine; Lysine; Methylation; Muscular Dystrophy, Animal; Mutation; Myosins; Pedigree; Peptide Fragments; Protein Processing, Post-Translational | 1981 |
Cytokine sensitivity and methylation of lysine in Rickettsia prowazekii EVir and interferon-resistant R. prowazekii strains.
Topics: Cells, Cultured; Cytokines; Drug Resistance; Humans; Interferons; Lysine; Methylation; Rickettsia prowazekii | 1994 |
Synthesis of nitrodiazirinyl derivatives of neurotoxin II from Naja naja oxiana and their interaction with the Torpedo californica nicotinic acetylcholine receptor.
Topics: Affinity Labels; Animals; Chromatography, High Pressure Liquid; Cobra Neurotoxin Proteins; Cross-Linking Reagents; Lysine; Magnetic Resonance Spectroscopy; Mass Spectrometry; Methylation; Oxidation-Reduction; Photochemistry; Receptors, Nicotinic; Torpedo; Trypsin; Ultraviolet Rays | 1995 |
[The effect of methylating lysine residues on properties of complexes of myosin subfragment-1 with ADP and phosphate analogs].
Topics: Adenosine Diphosphate; Animals; Lysine; Methylation; Muscle, Skeletal; Myosin Subfragments; Rabbits; Thermodynamics | 1995 |
Polylysine domain of K-ras 4B protein is crucial for malignant transformation.
Topics: 3T3 Cells; Amino Acid Sequence; Animals; Cell Compartmentation; Cell Membrane; Cell Transformation, Neoplastic; In Vitro Techniques; Lysine; Methylation; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein Prenylation; Protein Processing, Post-Translational; Proto-Oncogene Proteins p21(ras); Rats; Structure-Activity Relationship | 1994 |
Reductive methylation and pKa determination of the lysine side chains in calbindin D9k.
Topics: Calbindins; Hydrogen-Ion Concentration; Lysine; Magnetic Resonance Spectroscopy; Methylation; S100 Calcium Binding Protein G | 1994 |
Native like structure and stability of apo AI in a n-propanol/water solution as determined by 13C NMR.
Topics: 1-Propanol; Apolipoprotein A-I; Circular Dichroism; Humans; Hydrogen-Ion Concentration; Lysine; Magnetic Resonance Spectroscopy; Methylation; Protein Denaturation; Protein Structure, Secondary; Protein Structure, Tertiary | 1995 |
The relationship between the trimethylation of lysine 77 and cytochrome c metabolism in Saccharomyces cerevisiae.
Topics: Amino Acid Sequence; Base Sequence; Binding Sites; Cloning, Molecular; Cytochrome c Group; DNA Restriction Enzymes; Drug Stability; Gene Transfer Techniques; Heme; Lysine; Methylation; Molecular Sequence Data; Mutagenesis, Site-Directed; Plasmids; Saccharomyces cerevisiae | 1994 |
Effect of lysine methylation and other ATPase modulators on the active site of myosin subfragment 1.
Topics: Adenosine Diphosphate; Binding Sites; Cations; Hydrogen-Ion Concentration; In Vitro Techniques; Lysine; Methylation; Myosin Subfragments; Myosins; Osmolar Concentration; Structure-Activity Relationship | 1994 |
Site-directed mutagenesis of alpha-tubulin. Reductive methylation studies of the Lys 394 region.
Topics: Animals; Biophysical Phenomena; Biophysics; Cattle; Glutamates; Glutamic Acid; In Vitro Techniques; Lysine; Methylation; Microtubule Proteins; Mutagenesis, Site-Directed; Oxidation-Reduction; Tubulin | 1993 |
Lysine residues involved in the hysteresis and in the regulatory sites of spinach ribulose 1,5-bisphosphate carboxylase/oxygenase.
Topics: Amino Acid Sequence; Binding Sites; Chromatography, High Pressure Liquid; Enzyme Activation; Lysine; Methylation; Molecular Sequence Data; Pentosephosphates; Ribulose-Bisphosphate Carboxylase; Sequence Alignment; Sequence Homology, Amino Acid; Sugar Alcohols; Trypsin; Vegetables | 1993 |
Carbon-13 NMR studies of the lysine side chains of calmodulin and its proteolytic fragments.
Topics: Amino Acid Sequence; Animals; Calmodulin; Carbon Isotopes; Cattle; Lysine; Magnetic Resonance Spectroscopy; Male; Methylation; Peptide Fragments; Protein Conformation; Testis; Trypsin | 1993 |
Lysine methylation of mitochondrial ATP synthase subunit c stored in tissues of dogs with hereditary ceroid lipofuscinosis.
Topics: Amino Acid Sequence; Animals; Brain; Dog Diseases; Dogs; Humans; Kidney; Lysine; Lysosomes; Macromolecular Substances; Methylation; Mitochondria; Molecular Sequence Data; Neuronal Ceroid-Lipofuscinoses; Proton-Translocating ATPases; Sheep | 1994 |
CCK-A-selective tetrapeptides containing lys(N epsilon)-amide residues: favorable in vivo and in vitro effects of N-methylation at the aspartyl residue.
Topics: Amino Acid Sequence; Animals; Appetite Depressants; Aspartic Acid; Cerebral Cortex; Cholecystokinin; Eating; Guinea Pigs; Hydrolysis; Lysine; Methylation; Molecular Sequence Data; Oligopeptides; Pancreas; Phosphatidylinositols; Rats; Receptors, Cholecystokinin; Structure-Activity Relationship; Tetragastrin | 1994 |
Ion pair formation involving methylated lysine side chains: a theoretical study.
Topics: Acetates; Ethylamines; Formates; Ions; Lysine; Mathematical Computing; Methylamines; Methylation; Models, Chemical; Models, Molecular; Models, Theoretical; Organophosphorus Compounds; Protein Conformation; Protein Processing, Post-Translational | 1994 |
Conformation of apolipoprotein E in lipoproteins.
Topics: Animals; Apolipoproteins E; Circular Dichroism; Dimyristoylphosphatidylcholine; Dogs; Humans; In Vitro Techniques; Lipoproteins; Lysine; Magnetic Resonance Spectroscopy; Methylation; Protein Conformation | 1993 |
In vitro aging of calmodulin generates isoaspartate at multiple Asn-Gly and Asp-Gly sites in calcium-binding domains II, III, and IV.
Topics: Amino Acid Sequence; Animals; Asparagine; Aspartic Acid; Binding Sites; Brain Chemistry; Calcium; Calmodulin; Cattle; Chromatography, High Pressure Liquid; Hydrogen-Ion Concentration; Lysine; Methylation; Molecular Sequence Data; Peptide Fragments; Protein Conformation; Protein D-Aspartate-L-Isoaspartate Methyltransferase; Protein Methyltransferases; Time Factors; Trypsin | 1993 |
Structural consequences of reductive methylation of lysine residues in hen egg white lysozyme: an X-ray analysis at 1.8-A resolution.
Topics: Animals; Chickens; Crystallography; Lysine; Methylation; Muramidase; Oxidation-Reduction; Protein Structure, Secondary; Protein Structure, Tertiary; X-Ray Diffraction | 1993 |
Kinetic characterization of reductively methylated myosin subfragment 1.
Topics: Actomyosin; Animals; Chickens; Kinetics; Lysine; Methylation; Myosin Subfragments; Myosins; Oxidation-Reduction; Spectrometry, Fluorescence; Structure-Activity Relationship | 1993 |
Structural requirements for the binding of modified proteins to the scavenger receptor of macrophages.
Topics: Apolipoproteins B; Humans; Immunoglobulin Fab Fragments; Immunoglobulin G; Lipoproteins, LDL; Lysine; Methylation; Oxidation-Reduction; Protein Binding; Protein Conformation; Receptors, Cell Surface; Receptors, Immunologic; Receptors, Scavenger; Serum Albumin; Serum Albumin, Bovine | 1993 |
Dynamic methylation of alfalfa histone H3.
Topics: Cells, Cultured; Chromatography, High Pressure Liquid; Histones; Lysine; Medicago sativa; Methylation | 1993 |
Role of the charge pair aspartic acid-237-lysine-358 in the lactose permease of Escherichia coli.
Topics: Amino Acid Sequence; Aspartic Acid; Base Sequence; Biological Transport, Active; Cysteine; Electrochemistry; Enzyme Stability; Escherichia coli; Escherichia coli Proteins; Kinetics; Lactose; Lysine; Membrane Transport Modulators; Membrane Transport Proteins; Methylation; Molecular Sequence Data; Monosaccharide Transport Proteins; Mutagenesis, Site-Directed; Structure-Activity Relationship; Sulfhydryl Reagents; Symporters | 1993 |
Characterization of yeast EF-1 alpha: non-conservation of post-translational modifications.
Topics: Amino Acid Sequence; Cyanogen Bromide; Endopeptidases; Lysine; Methylation; Molecular Sequence Data; Peptide Elongation Factor 1; Peptide Elongation Factors; Protein Processing, Post-Translational; Saccharomyces cerevisiae; Sequence Alignment; Trypsin | 1993 |
Opsin/all-trans-retinal complex activates transducin by different mechanisms than photolyzed rhodopsin.
Topics: Animals; Binding Sites; Cattle; Darkness; GTP-Binding Proteins; Hydrogen-Ion Concentration; Kinetics; Light; Lysine; Methylation; Photolysis; Retinaldehyde; Rhodopsin; Rod Cell Outer Segment; Rod Opsins; Schiff Bases; Spectrophotometry; Stereoisomerism; Transducin | 1996 |
Surface labelling of the type I methyltransferase M.EcoR124I reveals lysine residues critical for DNA binding.
Topics: alpha-MSH; Amino Acid Sequence; Amino Acids; Conserved Sequence; DNA; Lysine; Methylation; Molecular Sequence Data; Peptide Fragments; Protein Binding; Sequence Analysis; Site-Specific DNA-Methyltransferase (Adenine-Specific) | 1996 |
Differential scanning calorimetric study of the complexes of modified myosin subfragment 1 with ADP and vanadate or beryllium fluoride.
Topics: Adenosine Diphosphate; Animals; Beryllium; Calorimetry, Differential Scanning; Fluorides; Indicators and Reagents; Lysine; Methylation; Myosin Subfragments; Picrates; Rabbits; Structure-Activity Relationship; Sulfhydryl Compounds; Vanadates | 1996 |
Structural evidence for an anion-directing track in the hen ovotransferrin N-lobe: implications for transferrin synergistic anion binding.
Topics: Amino Acid Sequence; Animals; Anions; Chickens; Conalbumin; Histidine; Lysine; Magnetic Resonance Spectroscopy; Mass Spectrometry; Methylation; Molecular Sequence Data; Peptide Fragments; Protein Binding; Protein Conformation; Protein Structure, Secondary; Pyruvates; Tyrosine | 1996 |
Sequence requirement for trimethylation of yeast cytochrome c.
Topics: Amino Acid Sequence; Cytochrome c Group; Cytochromes c; Lysine; Methylation; Molecular Sequence Data; Mutagenesis, Site-Directed; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins | 1997 |
Site-directed mutants of post-translationally modified sites of yeast eEF1A using a shuttle vector containing a chromogenic switch.
Topics: beta-Galactosidase; Fungal Proteins; Genes, Reporter; Genetic Vectors; Kinetics; Lysine; Methylation; Mutagenesis, Site-Directed; Peptide Biosynthesis; Peptide Elongation Factor 1; Peptide Elongation Factors; Peptides; Phenotype; Protein Biosynthesis; Protein Processing, Post-Translational; RNA, Transfer, Amino Acyl; Saccharomyces cerevisiae | 1997 |
Post-translational processing of rat ribosomal proteins. Ubiquitous methylation of Lys22 within the zinc-finger motif of RL40 (carboxy-terminal extension protein 52) and tissue-specific methylation of Lys4 in RL29.
Topics: Amino Acid Sequence; Animals; Brain; Chromatography, High Pressure Liquid; Fungal Proteins; Liver; Lysine; Methylation; Molecular Sequence Data; Protein Precursors; Protein Processing, Post-Translational; Rats; Ribosomal Proteins; Subcellular Fractions; Thymus Gland; Ubiquitins; Zinc Fingers | 1997 |
Oxidation of low density lipoprotein particles decreases their ability to bind to human aortic proteoglycans. Dependence on oxidative modification of the lysine residues.
Topics: Animals; Aorta; Apolipoprotein B-100; Apolipoproteins B; Cell-Free System; Chondroitin Sulfates; Chromatography, Affinity; Copper Sulfate; Heparin; Humans; Lipoproteins, LDL; Lysine; Macrophages, Peritoneal; Malondialdehyde; Methylation; Mice; Oxidation-Reduction; Proteoglycans | 1997 |
Thermodynamic characterization of non-sequence-specific DNA-binding by the Sso7d protein from Sulfolobus solfataricus.
Topics: Archaeal Proteins; Base Sequence; Binding Sites; Calorimetry; Deuterium Oxide; DNA-Binding Proteins; DNA, Archaeal; Hydrogen-Ion Concentration; Lysine; Macromolecular Substances; Methylation; Osmotic Pressure; Poly dA-dT; Polydeoxyribonucleotides; Protein Binding; Spectrometry, Fluorescence; Sulfolobus; Temperature; Thermodynamics; Water | 1998 |
Bacterial expression of a mitochondrial cytochrome c. Trimethylation of lys72 in yeast iso-1-cytochrome c and the alkaline conformational transition.
Topics: Alkalies; Bacterial Proteins; Cytochrome c Group; Cytochromes c; Electrochemistry; Electron Spin Resonance Spectroscopy; Escherichia coli; Lyases; Lysine; Magnetic Resonance Spectroscopy; Mass Spectrometry; Methylation; Mitochondria; Protein Conformation; Recombinant Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Spectrophotometry, Ultraviolet | 1998 |
Methylated Nepsilon-dansyl-L-lysine as a fluorogenic reagent for the chiral separation of carboxylic acids.
Topics: Amino Acids; Carboxylic Acids; Chromatography, High Pressure Liquid; Fluorescent Dyes; Indicators and Reagents; Lysine; Methylation | 1998 |
Dynamics of histone acetylation in Chlamydomonas reinhardtii.
Topics: Acetates; Acetyl Coenzyme A; Acetylation; Animals; Chlamydomonas reinhardtii; Half-Life; Histone Deacetylase Inhibitors; Histones; Hydroxamic Acids; Kinetics; Lysine; Methylation; Protein Processing, Post-Translational | 1998 |
Crystallization and improvement of crystal quality for x-ray diffraction of maltooligosyl trehalose synthase by reductive methylation of lysine residues.
Topics: Archaeal Proteins; Crystallization; Glucosyltransferases; Lysine; Methylation; Sulfolobus acidocaldarius; X-Ray Diffraction | 1999 |
High-throughput mass spectrometric discovery of protein post-translational modifications.
Topics: Acetylation; Amides; Amino Acid Sequence; Amino Acid Substitution; Cysteine; Escherichia coli; Image Processing, Computer-Assisted; Keratins; Lysine; Methionine; Methylation; Molecular Sequence Data; Oxidoreductases; Peptide Elongation Factor Tu; Peptide Mapping; Peroxidases; Peroxiredoxins; Phenylalanine; Protein Processing, Post-Translational; Software; Species Specificity; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Tyrosine | 1999 |
Protein aging by carboxymethylation of lysines generates sites for divalent metal and redox active copper binding: relevance to diseases of glycoxidative stress.
Topics: Animals; Ascorbic Acid; Binding Sites; Biopolymers; Catalysis; Cations, Divalent; Collagen; Copper; Diabetes Mellitus, Experimental; Free Radicals; Glycation End Products, Advanced; Humans; Hydrogen Peroxide; Kidney Failure, Chronic; Lysine; Methylation; Oxidation-Reduction; Oxidative Stress; Peroxidase; Rats; Rats, Sprague-Dawley; Serine | 1999 |
Measurement of carnitine precursors, epsilon-trimethyllysine and gamma-butyrobetaine in human serum by tandem mass spectrometry.
Topics: Betaine; Carnitine; Humans; Lysine; Mass Spectrometry; Methylation; Reference Standards; Sensitivity and Specificity | 1999 |
Methylation of histone H3 at lysine 4 is highly conserved and correlates with transcriptionally active nuclei in Tetrahymena.
Topics: Acetyltransferases; Amino Acid Sequence; Animals; Cell Nucleus; HeLa Cells; Histone Acetyltransferases; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Methyltransferases; Molecular Sequence Data; Protein Methyltransferases; Protein Processing, Post-Translational; Saccharomyces cerevisiae Proteins; Species Specificity; Tetrahymena thermophila; Transcription, Genetic; Yeasts | 1999 |
Structural requirements for N-trimethylation of lysine 115 of calmodulin.
Topics: Amino Acid Sequence; Base Sequence; Calmodulin; Lysine; Methylation; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein Conformation | 2000 |
Cytochrome c methyltransferase, Ctm1p, of yeast.
Topics: Amino Acid Sequence; Amino Acids; Apoproteins; Base Sequence; Cell Fractionation; Cytochrome c Group; Cytochromes c; Cytosol; Fungal Proteins; Histone-Lysine N-Methyltransferase; Lysine; Methylation; Molecular Sequence Data; Mutation; RNA, Messenger; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sequence Alignment; Spectrophotometry | 2000 |
Determinants of cytochrome c pro-apoptotic activity. The role of lysine 72 trimethylation.
Topics: Amino Acid Sequence; Animals; Apoptosis; Cytochrome c Group; Cytochromes c; Horses; Lysine; Methylation; Mitochondria; Models, Molecular; Molecular Sequence Data; Oocytes; Peptide Hydrolases; Protein Isoforms; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sequence Homology, Amino Acid; Xenopus | 2000 |
Pellicle precursor protein crosslinking characterization of an adduct between acidic proline-rich protein (PRP-1) and statherin generated by transglutaminase.
Topics: Amino Acids; Chromatography, High Pressure Liquid; Cross-Linking Reagents; Dental Deposits; Dental Pellicle; Electrophoresis, Polyacrylamide Gel; Glutamine; Humans; Hydrolysis; Lysine; Mass Spectrometry; Methylation; Molecular Weight; Peptides; Proline; Proline-Rich Protein Domains; Protein Precursors; Protein Processing, Post-Translational; Proteins; Salivary Proteins and Peptides; Transglutaminases | 2000 |
Regulation of chromatin structure by site-specific histone H3 methyltransferases.
Topics: Amino Acid Sequence; Animals; Catalytic Domain; Chromatin; Drosophila; HeLa Cells; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Humans; Lysine; Methylation; Methyltransferases; Mice; Molecular Sequence Data; Phosphorylation; Protein Conformation; Protein Methyltransferases; Protein Structure, Tertiary; Recombinant Proteins; Repressor Proteins; Sequence Homology, Amino Acid; Serine; Substrate Specificity | 2000 |
X-ray crystallographic analysis of pokeweed antiviral protein-II after reductive methylation of lysine residues.
Topics: Crystallography, X-Ray; Lysine; Methylation; N-Glycosyl Hydrolases; Plant Proteins; Protein Conformation; Ribosome Inactivating Proteins, Type 1 | 2000 |
Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins.
Topics: Amino Acid Sequence; Animals; Binding Sites; Chromatin; DNA-Binding Proteins; Fibroblasts; Gene Expression Regulation; Hepatocyte Nuclear Factor 1; Hepatocyte Nuclear Factor 1-alpha; Hepatocyte Nuclear Factor 1-beta; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Methyltransferases; Mice; Molecular Sequence Data; Mutation; Nuclear Proteins; Protein Binding; Protein Methyltransferases; Repressor Proteins; Transcription Factors | 2001 |
Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain.
Topics: Amino Acid Sequence; Cell Cycle Proteins; Cell Line; Chromatin; Chromobox Protein Homolog 5; Chromosomal Proteins, Non-Histone; Fungal Proteins; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Methyltransferases; Molecular Sequence Data; Protein Structure, Tertiary; Recombinant Fusion Proteins; Saccharomyces cerevisiae Proteins; Schizosaccharomyces; Schizosaccharomyces pombe Proteins; Transcription Factors | 2001 |
Physical association between the histone acetyl transferase CBP and a histone methyl transferase.
Topics: Acetylation; Acetyltransferases; Amino Acids; Cell Cycle Proteins; Cell Nucleus; CREB-Binding Protein; HeLa Cells; Histone Acetyltransferases; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Methyltransferases; Nuclear Proteins; Nucleosomes; p300-CBP Transcription Factors; Precipitin Tests; Protein Binding; Protein Methyltransferases; Saccharomyces cerevisiae Proteins; Trans-Activators; Transcription Factors; Transcriptional Activation | 2001 |
Role of histone H3 lysine 9 methylation in epigenetic control of heterochromatin assembly.
Topics: Acetylation; Cell Cycle Proteins; Centromere; Chromosomes, Fungal; Fungal Proteins; Gene Silencing; Genes, Fungal; Heterochromatin; Histone Deacetylases; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Methyltransferases; Mutation; Protein Methyltransferases; Protein Structure, Tertiary; Recombinant Proteins; Saccharomyces cerevisiae Proteins; Schizosaccharomyces; Schizosaccharomyces pombe Proteins; Transcription Factors | 2001 |
Molecular biology. The histone modification circus.
Topics: Acetylation; Cell Cycle Proteins; Centromere; Chromatin; Fungal Proteins; Gene Expression Regulation, Fungal; Gene Silencing; Heterochromatin; Histone Deacetylases; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Methyltransferases; Phosphorylation; Protein Binding; Protein Methyltransferases; Protein Structure, Tertiary; Saccharomyces cerevisiae Proteins; Schizosaccharomyces; Schizosaccharomyces pombe Proteins; Serine; Transcription Factors | 2001 |
Set domain-containing protein, G9a, is a novel lysine-preferring mammalian histone methyltransferase with hyperactivity and specific selectivity to lysines 9 and 27 of histone H3.
Topics: Amino Acid Sequence; Catalysis; Chromatin; Electrophoresis, Polyacrylamide Gel; Histones; Humans; Lysine; Methylation; Methyltransferases; Molecular Sequence Data; Protein Conformation; Repressor Proteins; Substrate Specificity | 2001 |
Chemical modification of lysine by reductive methylation. A probe for residues involved in DNA binding.
Topics: Chromatography, High Pressure Liquid; DNA; DNA-Binding Proteins; Formaldehyde; Indicators and Reagents; Kinetics; Lysine; Methylation; Methylene Chloride; Oxidation-Reduction; Site-Specific DNA-Methyltransferase (Adenine-Specific); Tritium | 2001 |
Methylation of histone H4 at arginine 3 facilitating transcriptional activation by nuclear hormone receptor.
Topics: Acetylation; Amino Acid Sequence; Animals; Arginine; Binding Sites; Cell Nucleus; HeLa Cells; Histones; Humans; Hydroxamic Acids; Intracellular Signaling Peptides and Proteins; Lysine; Methylation; Methyltransferases; Molecular Sequence Data; Mutation; Oocytes; Protein-Arginine N-Methyltransferases; Receptors, Androgen; Recombinant Proteins; S-Adenosylmethionine; Transcriptional Activation; Xenopus | 2001 |
Rb targets histone H3 methylation and HP1 to promoters.
Topics: Amino Acid Sequence; Animals; Cell Line; Chromobox Protein Homolog 5; Chromosomal Proteins, Non-Histone; Cyclin E; Escherichia coli; Female; HeLa Cells; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Methyltransferases; Mice; Molecular Sequence Data; Promoter Regions, Genetic; Protein Binding; Protein Methyltransferases; Recombinant Fusion Proteins; Repressor Proteins; Retinoblastoma Protein | 2001 |
Correlation between histone lysine methylation and developmental changes at the chicken beta-globin locus.
Topics: Acetylation; Animals; Avian Proteins; Brain; Carrier Proteins; Chick Embryo; Chromatin; Erythrocytes; Erythroid Precursor Cells; Erythropoiesis; Folate Receptors, GPI-Anchored; Gene Expression Regulation, Developmental; Gene Silencing; Globins; Histones; Locus Control Region; Lysine; Membrane Proteins; Methylation; Receptors, Cell Surface; Receptors, Odorant; Transcriptional Activation | 2001 |
Transitions in distinct histone H3 methylation patterns at the heterochromatin domain boundaries.
Topics: DNA, Fungal; Euchromatin; Fungal Proteins; Gene Silencing; Genes, Fungal; Genes, Mating Type, Fungal; Heterochromatin; Histones; Lysine; Methylation; Models, Genetic; Precipitin Tests; Repetitive Sequences, Nucleic Acid; Saccharomyces cerevisiae Proteins; Schizosaccharomyces; Transcription Factors; Transcription, Genetic | 2001 |
Physical and functional association of SU(VAR)3-9 and HDAC1 in Drosophila.
Topics: Animals; Blotting, Western; Chromatin; Drosophila; Fungal Proteins; Gene Silencing; Genes, Dominant; Genome; Histone Deacetylase 1; Histone Deacetylases; Histones; Lysine; Methylation; Methyltransferases; Mutation; Precipitin Tests; Protein Binding; Protein Structure, Tertiary; Recombinant Proteins; Salts; Transcription, Genetic | 2001 |
Molecular biology. Methylation talk between histones and DNA.
Topics: 5-Methylcytosine; Acetylation; Amino Acid Substitution; Animals; Cytosine; DNA Methylation; DNA, Fungal; Gene Silencing; Histones; Lysine; Methylation; Methyltransferases; Mutation; Neurospora crassa | 2001 |
Differentially methylated forms of histone H3 show unique association patterns with inactive human X chromosomes.
Topics: Animals; Cells, Cultured; CHO Cells; Cricetinae; Cricetulus; Dosage Compensation, Genetic; Female; Heterochromatin; Histones; Humans; Hybrid Cells; In Situ Hybridization, Fluorescence; Lysine; Metaphase; Methylation; Microscopy, Fluorescence; Precipitin Tests; Protein Isoforms; X Chromosome | 2002 |
Histone H3 lysine 9 methylation is an epigenetic imprint of facultative heterochromatin.
Topics: Amniocentesis; Aneuploidy; Animals; Binding Sites; Cells, Cultured; Chromosome Painting; Chromosomes, Human, Pair 4; Dosage Compensation, Genetic; Female; Fibroblasts; Gene Expression Regulation; Heterochromatin; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Male; Metaphase; Methylation; Methyltransferases; Mice; Microscopy, Fluorescence; Mouth Mucosa; Precipitin Tests; Pregnancy; Protein Binding; Protein Isoforms; Protein Methyltransferases; Repressor Proteins; Translocation, Genetic; X Chromosome | 2002 |
The Saccharomyces cerevisiae Set1 complex includes an Ash2 homologue and methylates histone 3 lysine 4.
Topics: Amino Acid Sequence; Base Sequence; Blotting, Southern; DNA Primers; DNA-Binding Proteins; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Molecular Sequence Data; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sequence Homology, Amino Acid; Transcription Factors | 2001 |
Hormone-dependent, CARM1-directed, arginine-specific methylation of histone H3 on a steroid-regulated promoter.
Topics: Acetylation; Arginine; Fluorescent Antibody Technique; Histones; Hormones; Lysine; Mammary Tumor Virus, Mouse; Methylation; Phosphorylation; Precipitin Tests; Promoter Regions, Genetic; Protein-Arginine N-Methyltransferases; Serine; Steroids | 2001 |
Histone H3 lysine 4 methylation is mediated by Set1 and required for cell growth and rDNA silencing in Saccharomyces cerevisiae.
Topics: Animals; Antibody Formation; Blotting, Western; Cell Division; DNA Primers; DNA-Binding Proteins; DNA, Bacterial; DNA, Ribosomal; Fungal Proteins; Gene Silencing; Genetic Vectors; Heterochromatin; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Methyltransferases; Mutation; Nucleosomes; Polymerase Chain Reaction; Precipitin Tests; Protein Methyltransferases; Rabbits; RNA Polymerase III; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Transcription Factors | 2001 |
A trithorax-group complex purified from Saccharomyces cerevisiae is required for methylation of histone H3.
Topics: Animals; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Chromatin; DNA-Binding Proteins; Dosage Compensation, Genetic; Drosophila melanogaster; Drosophila Proteins; Electrophoresis, Polyacrylamide Gel; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Models, Genetic; Mutation; Nuclear Proteins; Phenotype; Protein Binding; Protein Structure, Tertiary; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sex Factors; Transcription Factors; X Chromosome | 2002 |
Purification and functional characterization of a histone H3-lysine 4-specific methyltransferase.
Topics: Acetylation; Acetyltransferases; Amino Acid Sequence; Animals; Binding, Competitive; Cell Cycle Proteins; DNA, Complementary; Gene Silencing; HeLa Cells; Heterochromatin; Histone Acetyltransferases; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Methyltransferases; Mice; Molecular Sequence Data; Molecular Weight; Nucleosomes; p300-CBP Transcription Factors; Protein Methyltransferases; Protein Structure, Tertiary; Substrate Specificity; Transcription Factors | 2001 |
COMPASS, a histone H3 (Lysine 4) methyltransferase required for telomeric silencing of gene expression.
Topics: Chromosomes, Fungal; Gene Silencing; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Lysine; Methylation; Methyltransferases; Protein Methyltransferases; Saccharomyces cerevisiae; Telomere | 2002 |
Histone H3 lysine 9 methylation occurs rapidly at the onset of random X chromosome inactivation.
Topics: Cell Differentiation; Dosage Compensation, Genetic; Female; Gene Silencing; Histones; Humans; In Situ Hybridization, Fluorescence; Lysine; Metaphase; Methylation; Microscopy, Fluorescence; Stem Cells; Time Factors; X Chromosome; Y Chromosome | 2002 |
Histone H3 lysine 4 methylation disrupts binding of nucleosome remodeling and deacetylase (NuRD) repressor complex.
Topics: Acetylation; Blotting, Western; Cell Nucleus; Electrophoresis, Polyacrylamide Gel; HeLa Cells; Histone Deacetylases; Histones; Humans; Lysine; Mass Spectrometry; Methylation; Mi-2 Nucleosome Remodeling and Deacetylase Complex; Peptides; Precipitin Tests; Protein Binding; Protein Structure, Tertiary; Transcription, Genetic | 2002 |
Structure of HP1 chromodomain bound to a lysine 9-methylated histone H3 tail.
Topics: Amino Acid Motifs; Amino Acid Sequence; Chromobox Protein Homolog 5; Chromosomal Proteins, Non-Histone; Crystallography, X-Ray; Drosophila Proteins; Histones; Hydrogen Bonding; Lysine; Methylation; Models, Molecular; Molecular Sequence Data; Mutagenesis; Peptides; Point Mutation; Protein Binding; Protein Conformation; Protein Structure, Secondary; Protein Structure, Tertiary; Sequence Alignment | 2002 |
SETDB1: a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins.
Topics: Animals; Cell Line; Chromobox Protein Homolog 5; Chromosomal Proteins, Non-Histone; DNA-Binding Proteins; Euchromatin; Fluorescent Antibody Technique, Indirect; Gene Silencing; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Macromolecular Substances; Methylation; Mice; Molecular Sequence Data; Nuclear Proteins; Protein Binding; Protein Methyltransferases; Protein Structure, Tertiary; Repressor Proteins; Sequence Homology, Amino Acid; Substrate Specificity; Transcription Factors; Tripartite Motif-Containing Protein 28; Two-Hybrid System Techniques; Zinc Fingers | 2002 |
Protein N-methyltransferase assays in the study of gene transcription.
Topics: Amino Acid Sequence; Animals; Arginine; Drosophila; HeLa Cells; Histones; Humans; Lysine; Methylation; Methyltransferases; Molecular Biology; Molecular Sequence Data; Peptides; Recombinant Fusion Proteins; Transcription, Genetic | 2002 |
Heterochromatin, HP1 and methylation at lysine 9 of histone H3 in animals.
Topics: Animals; Bisbenzimidazole; Chromobox Protein Homolog 5; Chromosomal Proteins, Non-Histone; DNA; Drosophila; Female; Fluorescent Antibody Technique; Gene Silencing; Genomic Imprinting; Heterochromatin; Histones; Lysine; Male; Methylation; Mice; Microscopy, Fluorescence; Oocytes; Spermatozoa | 2002 |
Methylation of histone H3 by COMPASS requires ubiquitination of histone H2B by Rad6.
Topics: DNA, Ribosomal; Electrophoresis, Polyacrylamide Gel; Gene Silencing; Histones; Ligases; Lysine; Methylation; Models, Biological; Mutation; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Ubiquitin; Ubiquitin-Conjugating Enzymes | 2002 |
Dependence of heterochromatic histone H3 methylation patterns on the Arabidopsis gene DDM1.
Topics: Amino Acid Sequence; Animals; Arabidopsis; Arabidopsis Proteins; DNA Methylation; DNA Transposable Elements; DNA-Binding Proteins; DNA, Plant; Gene Expression; Gene Expression Profiling; Gene Silencing; Genes, Plant; Heterochromatin; Histones; Humans; Lysine; Methylation; Molecular Sequence Data; Reverse Transcriptase Polymerase Chain Reaction; Sequence Alignment; Transcription Factors | 2002 |
Lysine methylation within the globular domain of histone H3 by Dot1 is important for telomeric silencing and Sir protein association.
Topics: Amino Acid Sequence; Animals; Blotting, Western; Cattle; Crystallography, X-Ray; Fungal Proteins; Gene Silencing; Histone Deacetylases; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Molecular Sequence Data; Mutation; Nuclear Proteins; Precipitin Tests; Protein Binding; Protein Structure, Tertiary; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sequence Homology, Amino Acid; Silent Information Regulator Proteins, Saccharomyces cerevisiae; Sirtuin 2; Sirtuins; Telomere; Thymus Gland; Trans-Activators | 2002 |
A mark in the core: silence no more!
Topics: Chromatin; DNA Replication; Gene Silencing; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Models, Genetic; Nuclear Proteins; Nucleosomes; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins | 2002 |
PR-Set7 is a nucleosome-specific methyltransferase that modifies lysine 20 of histone H4 and is associated with silent chromatin.
Topics: Acetylation; Amino Acid Sequence; Animals; Chromatin; Drosophila melanogaster; Female; HeLa Cells; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Male; Methylation; Methyltransferases; Microscopy, Fluorescence; Molecular Sequence Data; Nucleosomes; Protein Methyltransferases; Recombinant Fusion Proteins; Sequence Alignment | 2002 |
Methylation of H3-lysine 79 is mediated by a new family of HMTases without a SET domain.
Topics: Amino Acid Sequence; Cell Cycle; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Methyltransferases; Molecular Sequence Data; Protein Methyltransferases; Protein Structure, Tertiary; Sequence Alignment; Substrate Specificity; Yeasts | 2002 |
Identification of acetylation and methylation sites of histone H3 from chicken erythrocytes by high-accuracy matrix-assisted laser desorption ionization-time-of-flight, matrix-assisted laser desorption ionization-postsource decay, and nanoelectrospray ion
Topics: Acetylation; Acetyltransferases; Animals; Chickens; Chromatography, High Pressure Liquid; Erythrocytes; Histones; Lysine; Methylation; Methyltransferases; Spectrometry, Mass, Electrospray Ionization; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Trypsin | 2002 |
G9a histone methyltransferase plays a dominant role in euchromatic histone H3 lysine 9 methylation and is essential for early embryogenesis.
Topics: Acetylation; Animals; Embryonic and Fetal Development; Euchromatin; Gene Targeting; Germ Cells; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Methyltransferases; Mice; Mice, Inbred C57BL; Mice, Knockout; Protein Methyltransferases; Repressor Proteins; Transcription, Genetic | 2002 |
Mycobacterial heparin-binding hemagglutinin and laminin-binding protein share antigenic methyllysines that confer resistance to proteolysis.
Topics: Adhesins, Bacterial; Animals; Antigens, Bacterial; Binding Sites; Bronchoalveolar Lavage Fluid; Epitopes, B-Lymphocyte; Hemagglutinins; Lectins; Lysine; Methylation; Mice; Mycobacterium bovis; Mycobacterium smegmatis; Mycobacterium tuberculosis; Protein O-Methyltransferase; Protein Processing, Post-Translational; Receptors, Laminin; Serine Endopeptidases; Trypsin | 2002 |
Postsynthetic trimethylation of histone H4 at lysine 20 in mammalian tissues is associated with aging.
Topics: Aging; Amino Acid Sequence; Animals; Cell Line; Chromatography, High Pressure Liquid; Histones; Humans; Lysine; Mass Spectrometry; Metalloendopeptidases; Methylation; Molecular Sequence Data; Protein Structure, Tertiary; Rats; Serine Endopeptidases; Time Factors | 2002 |
Ubiquitination of histone H2B by Rad6 is required for efficient Dot1-mediated methylation of histone H3 lysine 79.
Topics: Histone-Lysine N-Methyltransferase; Histones; Ligases; Lysine; Methylation; Nuclear Proteins; Nucleosomes; Saccharomyces cerevisiae Proteins; Ubiquitin; Ubiquitin-Conjugating Enzymes | 2002 |
Regulation of heterochromatic silencing and histone H3 lysine-9 methylation by RNAi.
Topics: Centromere; Chromosomal Proteins, Non-Histone; DNA Methylation; DNA Transposable Elements; Endoribonucleases; Gene Deletion; Gene Silencing; Genes, Fungal; Heterochromatin; Histones; Lysine; Methylation; Models, Genetic; Repetitive Sequences, Nucleic Acid; Ribonuclease III; RNA-Dependent RNA Polymerase; RNA, Double-Stranded; RNA, Fungal; RNA, Small Interfering; RNA, Untranslated; Schizosaccharomyces; Schizosaccharomyces pombe Proteins; Transcription, Genetic; Transgenes | 2002 |
Molecular biology. RNAi and heterochromatin--a hushed-up affair.
Topics: Animals; Centromere; Chromosomal Proteins, Non-Histone; DNA Transposable Elements; Dosage Compensation, Genetic; Gene Silencing; Genes, Fungal; Heterochromatin; Histones; Lysine; Methylation; Repetitive Sequences, Nucleic Acid; RNA, Double-Stranded; RNA, Fungal; RNA, Small Interfering; RNA, Untranslated; Schizosaccharomyces; Schizosaccharomyces pombe Proteins; Transcription, Genetic | 2002 |
Histone H3 lysine 4 methylation is mediated by Set1 and promotes maintenance of active chromatin states in fission yeast.
Topics: Cell Cycle; Chromatin; Fluorescent Antibody Technique; Histones; Lysine; Methylation; Schizosaccharomyces | 2002 |
Dynamic changes in histone H3 Lys 9 methylation occurring at tightly regulated inducible inflammatory genes.
Topics: Cells, Cultured; Chemokine CCL19; Chemokine CCL21; Chemokines, CC; Dendritic Cells; Gene Expression Regulation; Histones; Humans; Inflammation; Lipopolysaccharides; Lysine; Methylation; Promoter Regions, Genetic; RNA Polymerase II; Transcriptional Activation | 2002 |
Mitotic-specific methylation of histone H4 Lys 20 follows increased PR-Set7 expression and its localization to mitotic chromosomes.
Topics: Acetylation; Cell Cycle; Chromosomes; HeLa Cells; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Methyltransferases; Mitosis; Protein Methyltransferases; S Phase | 2002 |
Methylation of histone h3 at lysine 9 targets programmed DNA elimination in tetrahymena.
Topics: Amino Acid Sequence; Animals; Chromatin; Chromobox Protein Homolog 5; Chromosomal Proteins, Non-Histone; DNA-Binding Proteins; DNA, Protozoan; Escherichia coli; Gene Silencing; Histones; In Vitro Techniques; Lysine; Methylation; Molecular Sequence Data; Nuclear Proteins; Phosphoproteins; Protozoan Proteins; Recombinant Proteins; Sequence Alignment; Sequence Deletion; Tetrahymena thermophila | 2002 |
Role of histone H3 lysine 27 methylation in Polycomb-group silencing.
Topics: Animals; Carrier Proteins; Cell Cycle Proteins; Chromatin; DNA-Binding Proteins; Drosophila; Drosophila Proteins; Enhancer of Zeste Homolog 2 Protein; Gene Silencing; Genes, Homeobox; HeLa Cells; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Homeodomain Proteins; Humans; Lysine; Methylation; Methyltransferases; Nuclear Proteins; Nucleosomes; Peptide Mapping; Polycomb Repressive Complex 1; Polycomb Repressive Complex 2; Precipitin Tests; Protein Methyltransferases; Proteins; Repressor Proteins; Response Elements; RNA Interference; Temperature; Transcription Factors | 2002 |
Active genes are tri-methylated at K4 of histone H3.
Topics: Antibodies; DNA-Binding Proteins; Gene Expression Profiling; Gene Expression Regulation, Fungal; Genes, Fungal; Histone-Lysine N-Methyltransferase; Histones; Inositol; Lysine; Methionine; Methylation; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Transcription Factors; Transcription, Genetic | 2002 |
cis-acting DNA from fission yeast centromeres mediates histone H3 methylation and recruitment of silencing factors and cohesin to an ectopic site.
Topics: Binding Sites; Cell Cycle Proteins; Centromere; Chromatin; Chromosomal Proteins, Non-Histone; Cohesins; DNA; Fungal Proteins; Genes, Reporter; Histones; Lysine; Methylation; Nuclear Proteins; Plasmids; Recombination, Genetic; Repressor Proteins; Schizosaccharomyces; Schizosaccharomyces pombe Proteins; Silencer Elements, Transcriptional | 2002 |
Heterogeneity in the modification and involvement of chromatin components of the CpG island of the silenced human CDH1 gene in cancer cells.
Topics: Acetylation; Cadherins; Chromatin; Chromosomal Proteins, Non-Histone; CpG Islands; DNA Methylation; DNA-Binding Proteins; Gene Silencing; Histones; Humans; Lysine; Methyl-CpG-Binding Protein 2; Methylation; Neoplasms; Promoter Regions, Genetic; Protein Binding; Repressor Proteins; Tumor Cells, Cultured | 2002 |
Histone H3-lysine 9 methylation is associated with aberrant gene silencing in cancer cells and is rapidly reversed by 5-aza-2'-deoxycytidine.
Topics: Acetylation; Antimetabolites, Antineoplastic; Azacitidine; Culture Techniques; Cyclin-Dependent Kinase Inhibitor p16; Decitabine; DNA Methylation; Gene Silencing; Histones; Humans; Lysine; Methylation; Precipitin Tests; Tumor Cells, Cultured; Tumor Suppressor Protein p14ARF; Urinary Bladder Neoplasms | 2002 |
Activating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteins.
Topics: Amino Acid Motifs; Amino Acid Sequence; Animals; Carrier Proteins; Cation Transport Proteins; Cell Nucleus; DNA-Binding Proteins; Drosophila Proteins; HeLa Cells; Histones; Humans; Intracellular Signaling Peptides and Proteins; Lysine; Macromolecular Substances; Methylation; Molecular Sequence Data; Nuclear Proteins; Nuclear Receptor Coactivators; Receptors, Retinoic Acid; Saccharomyces cerevisiae Proteins; Sequence Homology, Amino Acid; Transcription Factors; Tubulin | 2003 |
Critical role of histone methylation in tumor suppressor gene silencing in colorectal cancer.
Topics: Adaptor Proteins, Signal Transducing; Azacitidine; Carrier Proteins; Colorectal Neoplasms; Cyclin-Dependent Kinase Inhibitor p16; Decitabine; DNA Methylation; Enzyme Inhibitors; Gene Silencing; Genes, Tumor Suppressor; Histone Deacetylase Inhibitors; Histones; Humans; Hydroxamic Acids; Lysine; Methylation; MutL Protein Homolog 1; Neoplasm Proteins; Nuclear Proteins; O(6)-Methylguanine-DNA Methyltransferase; Precipitin Tests; Promoter Regions, Genetic; Tumor Cells, Cultured | 2003 |
High conservation of the Set1/Rad6 axis of histone 3 lysine 4 methylation in budding and fission yeasts.
Topics: DNA-Binding Proteins; Histone-Lysine N-Methyltransferase; Histones; Ligases; Lysine; Mass Spectrometry; Methylation; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Schizosaccharomyces; Transcription Factors; Ubiquitin-Conjugating Enzymes | 2003 |
Crosstalk between CARM1 methylation and CBP acetylation on histone H3.
Topics: Acetylation; Acetyltransferases; Amino Acid Sequence; Arginine; Cells, Cultured; Chromatin; CREB-Binding Protein; Estrogens; Histones; Humans; Lysine; Methylation; Molecular Sequence Data; Nuclear Proteins; Promoter Regions, Genetic; Protein-Arginine N-Methyltransferases; Recombinant Proteins; Trans-Activators; Transcription, Genetic | 2002 |
Gene-specific targeting of H3K9 methylation is sufficient for initiating repression in vivo.
Topics: Cells, Cultured; Endothelial Growth Factors; Gene Expression Regulation; Histone Deacetylases; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Methyltransferases; Promoter Regions, Genetic; Protein Structure, Tertiary; Recombinant Proteins; Repressor Proteins; Transcription Factors; Vascular Endothelial Growth Factor A; Zinc Fingers | 2002 |
Mechanism of histone lysine methyl transfer revealed by the structure of SET7/9-AdoMet.
Topics: Amino Acid Sequence; Animals; Binding Sites; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Methyltransferases; Models, Molecular; Molecular Sequence Data; Molecular Structure; Mutagenesis, Site-Directed; Protein Conformation; Protein Methyltransferases; Repressor Proteins; S-Adenosylmethionine; Sequence Alignment | 2003 |
Bre1, an E3 ubiquitin ligase required for recruitment and substrate selection of Rad6 at a promoter.
Topics: Amino Acid Sequence; Gene Silencing; Histones; Ligases; Lysine; Methylation; Molecular Sequence Data; Open Reading Frames; Promoter Regions, Genetic; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sequence Alignment; Telomere; Ubiquitin; Ubiquitin-Conjugating Enzymes; Ubiquitin-Protein Ligases | 2003 |
A dimeric viral SET domain methyltransferase specific to Lys27 of histone H3.
Topics: Amino Acid Sequence; Animals; Binding Sites; Dimerization; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Methyltransferases; Models, Molecular; Molecular Sequence Data; Mutagenesis; Paramecium; Phycodnaviridae; Protein Conformation; Protein Methyltransferases; Protein Structure, Tertiary; S-Adenosylmethionine; Sequence Homology, Amino Acid; Structural Homology, Protein; Substrate Specificity; Viral Proteins | 2003 |
Lysine-79 of histone H3 is hypomethylated at silenced loci in yeast and mammalian cells: a potential mechanism for position-effect variegation.
Topics: Acetylation; Animals; Chromatin; DNA, Ribosomal; Gene Silencing; Histones; Lysine; Methylation; Mice; Saccharomyces cerevisiae; Transcription, Genetic | 2003 |
Balance between acetylation and methylation of histone H3 lysine 9 on the E2F-responsive dihydrofolate reductase promoter.
Topics: 3T3 Cells; Animals; Blood Proteins; Blotting, Western; Cell Cycle; Cell Cycle Proteins; Cell Line; Chromatin; DNA-Binding Proteins; E2F Transcription Factors; G1 Phase; Glutathione Transferase; Histones; Humans; Lysine; Methylation; Mice; Nuclear Proteins; Plasmids; Precipitin Tests; Promoter Regions, Genetic; Protein Binding; Protein Isoforms; Protein Structure, Tertiary; Proteins; Recombinant Fusion Proteins; Resting Phase, Cell Cycle; Retinoblastoma-Like Protein p107; Retinoblastoma-Like Protein p130; Reverse Transcriptase Polymerase Chain Reaction; Tetrahydrofolate Dehydrogenase; Time Factors; Transcription Factors; Transcription, Genetic; Transfection | 2003 |
Cascade of distinct histone modifications during collagenase gene activation.
Topics: Acetyltransferases; Blotting, Western; Chromatin; Collagenases; DNA; DNA Helicases; Enzyme Activation; Histone Acetyltransferases; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Methyltransferases; Models, Biological; Models, Genetic; Nuclear Proteins; Phosphorylation; Precipitin Tests; Promoter Regions, Genetic; Protein Binding; Protein Methyltransferases; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Reverse Transcriptase Polymerase Chain Reaction; Ribosomal Protein S6 Kinases, 90-kDa; RNA Polymerase II; RNA, Messenger; Saccharomyces cerevisiae Proteins; Time Factors; Trans-Activators; Transcription Factors; Transcription, Genetic; Transcriptional Activation; Transfection; Tumor Cells, Cultured | 2003 |
Epsilon -N,N,N-trimethyllysine-specific ions in matrix-assisted laser desorption/ionization-tandem mass spectrometry.
Topics: Acetylation; Amino Acid Sequence; Animals; Erythrocytes; Histones; Lysine; Methylation; Molecular Sequence Data; Protein Processing, Post-Translational; Spectrometry, Mass, Electrospray Ionization; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2003 |
Dynamic regulation of histone H3 methylated at lysine 79 within a tissue-specific chromatin domain.
Topics: Animals; Blotting, Western; Cell Differentiation; Cells, Cultured; Chromatin; Gene Silencing; Genetic Complementation Test; Globins; Histones; Lysine; Methylation; Mice; Models, Genetic; Precipitin Tests; Protein Structure, Tertiary; Reverse Transcriptase Polymerase Chain Reaction; Saccharomyces cerevisiae; Transcription, Genetic | 2003 |
Role of histone H3 lysine 27 methylation in X inactivation.
Topics: Animals; Blastocyst; Cell Differentiation; Cell Nucleus; Cells, Cultured; Dosage Compensation, Genetic; Female; Fluorescent Antibody Technique; Genomic Imprinting; HeLa Cells; Histones; Humans; In Situ Hybridization, Fluorescence; Lysine; Male; Methylation; Mice; Mutation; Polycomb Repressive Complex 2; Repressor Proteins; RNA, Long Noncoding; RNA, Untranslated; Stem Cells; Transgenes; Trophoblasts; X Chromosome | 2003 |
The Paf1 complex is required for histone H3 methylation by COMPASS and Dot1p: linking transcriptional elongation to histone methylation.
Topics: Blotting, Western; Chromatin; DNA Methylation; DNA-Binding Proteins; Electrophoresis, Polyacrylamide Gel; Gene Silencing; Genome, Fungal; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Methyltransferases; Models, Genetic; Mutation; Nuclear Proteins; Precipitin Tests; Protein Binding; Protein Methyltransferases; Proteome; RNA Polymerase II; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Telomere; Transcription Factors; Transcription, Genetic | 2003 |
Trimethylated lysine 9 of histone H3 is a mark for DNA methylation in Neurospora crassa.
Topics: DNA Methylation; DNA, Fungal; Fungal Proteins; Genes, Fungal; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Methyltransferases; Mutation; Neurospora crassa; Protein Methyltransferases; Protein Processing, Post-Translational | 2003 |
Structure of the O-specific polysaccharide of Providencia rustigianii O14 containing N(epsilon)-[(S)-1-carboxyethyl]-N(alpha)-(D-galacturonoyl)-L-lysine.
Topics: Carbohydrate Conformation; Carbohydrate Sequence; Lysine; Magnetic Resonance Spectroscopy; Methylation; Molecular Sequence Data; Monosaccharides; O Antigens; Providencia | 2003 |
Deletion and site-specific mutagenesis of nucleolin's carboxy GAR domain.
Topics: Amino Acid Motifs; Amino Acid Sequence; Animals; Arginine; ATP-Binding Cassette Transporters; Cell Nucleolus; CHO Cells; Cricetinae; DNA, Complementary; Escherichia coli; Gene Deletion; Green Fluorescent Proteins; HeLa Cells; Humans; Intracellular Signaling Peptides and Proteins; Luminescent Proteins; Lysine; Methylation; Methyltransferases; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Nucleolin; Peptides; Phosphoproteins; Protein Structure, Tertiary; Protein-Arginine N-Methyltransferases; RNA-Binding Proteins; Transfection | 2003 |
Enrichment for histone H3 lysine 9 methylation at Alu repeats in human cells.
Topics: Alu Elements; Base Sequence; Chromatin; Cloning, Molecular; DNA; DNA, Satellite; Histones; Humans; Lysine; Methylation; Molecular Sequence Data; Precipitin Tests; Recombination, Genetic; Terminal Repeat Sequences | 2003 |
The role of DNA methylation in setting up chromatin structure during development.
Topics: Acetylation; Animals; Chromatin; CpG Islands; DNA Methylation; Gene Expression Regulation, Developmental; Globins; Histones; Humans; Lysine; Methylation; Mice; Mice, Transgenic; Models, Genetic; Transfection | 2003 |
Changes in rat liver mitochondria with aging. Lon protease-like reactivity and N(epsilon)-carboxymethyllysine accumulation in the matrix.
Topics: Adenosine Triphosphate; Aging; Animals; Blotting, Western; Cell Survival; Electrophoresis, Polyacrylamide Gel; Endopeptidases; Enzyme-Linked Immunosorbent Assay; Immunochemistry; Lysine; Male; Methylation; Microscopy, Electron; Mitochondria; Mitochondria, Liver; Oxygen; Oxygen Consumption; Peptides; Rats; Rats, Wistar; Stress, Physiological; Time Factors | 2003 |
Methylation of histone H3 by Set2 in Saccharomyces cerevisiae is linked to transcriptional elongation by RNA polymerase II.
Topics: beta-Galactosidase; Chromatin; Gene Deletion; Histones; Immunoglobulin G; Lysine; Methylation; Methyltransferases; Models, Biological; Models, Genetic; Precipitin Tests; Protein Binding; Protein Structure, Tertiary; RNA Polymerase II; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Transcription, Genetic; Uracil | 2003 |
HP1 binding to native chromatin in vitro is determined by the hinge region and not by the chromodomain.
Topics: Amino Acid Sequence; Animals; Chickens; Chromatin; Chromobox Protein Homolog 5; Chromosomal Proteins, Non-Histone; Histones; Humans; Lysine; Methylation; Molecular Sequence Data; Nucleosomes; Protein Binding; Protein Isoforms; Protein Structure, Tertiary; Recombinant Fusion Proteins; Sequence Alignment; Xenopus laevis; Xenopus Proteins | 2003 |
Mechanism of multiple lysine methylation by the SET domain enzyme Rubisco LSMT.
Topics: Amino Acid Sequence; Catalysis; Crystallization; Lysine; Methylation; Models, Molecular; Molecular Sequence Data; Protein Conformation; Ribulose-Bisphosphate Carboxylase; Sequence Homology, Amino Acid; Substrate Specificity | 2003 |
Saccharomyces cerevisiae Set1p is a methyltransferase specific for lysine 4 of histone H3 and is required for efficient gene expression.
Topics: Amino Acid Sequence; Cluster Analysis; DNA-Binding Proteins; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Fungal; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Methyltransferases; Molecular Sequence Data; Oligonucleotide Array Sequence Analysis; RNA, Fungal; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sequence Homology, Amino Acid; Substrate Specificity; Transcription Factors; Transcription, Genetic | 2003 |
Sir2 regulates histone H3 lysine 9 methylation and heterochromatin assembly in fission yeast.
Topics: Acetylation; Chromosomal Proteins, Non-Histone; Chromosome Mapping; Gene Silencing; Heterochromatin; Histones; Lysine; Methylation; Methyltransferases; Polymerase Chain Reaction; Precipitin Tests; Schizosaccharomyces; Schizosaccharomyces pombe Proteins; Sirtuins; Staining and Labeling | 2003 |
Reactivation of the silenced and imprinted alleles of ARHI is associated with increased histone H3 acetylation and decreased histone H3 lysine 9 methylation.
Topics: Acetylation; Alleles; Cell Line, Tumor; Chromatin; DNA-Cytosine Methylases; Gene Components; Gene Expression Regulation; Histones; Humans; Lysine; Methylation; Precipitin Tests; Reverse Transcriptase Polymerase Chain Reaction; rho GTP-Binding Proteins; RNA | 2003 |
The Rtf1 component of the Paf1 transcriptional elongation complex is required for ubiquitination of histone H2B.
Topics: Blotting, Western; Chromatin; Dimerization; Dithiothreitol; Gene Deletion; Gene Silencing; Histones; Lysine; Methylation; Nuclear Proteins; Plasmids; Precipitin Tests; RNA, Messenger; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; TATA-Box Binding Protein; Telomere; Transcription Factors; Transcription, Genetic; Ubiquitin | 2003 |
The Paf1 complex is essential for histone monoubiquitination by the Rad6-Bre1 complex, which signals for histone methylation by COMPASS and Dot1p.
Topics: DNA Polymerase II; Histone-Lysine N-Methyltransferase; Histones; Ligases; Lysine; Methylation; Nuclear Proteins; RNA Polymerase II; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Ubiquitin; Ubiquitin-Conjugating Enzymes | 2003 |
Structural basis for specific binding of Polycomb chromodomain to histone H3 methylated at Lys 27.
Topics: Amino Acid Sequence; Animals; Chromatin; Crystallography, X-Ray; Drosophila; Drosophila Proteins; Glutathione Transferase; Heterochromatin; Histones; Lysine; Methylation; Models, Molecular; Molecular Sequence Data; Polycomb Repressive Complex 1; Protein Binding; Protein Structure, Tertiary; Recombinant Fusion Proteins; Sequence Homology, Amino Acid | 2003 |
Molecular basis for the discrimination of repressive methyl-lysine marks in histone H3 by Polycomb and HP1 chromodomains.
Topics: Amino Acid Motifs; Amino Acid Sequence; Animals; Binding Sites; Cell Nucleus; Chromatin; Chromobox Protein Homolog 5; Chromosomal Proteins, Non-Histone; Crystallography, X-Ray; Dose-Response Relationship, Drug; Drosophila melanogaster; Escherichia coli; Histones; Lysine; Methylation; Microscopy, Fluorescence; Models, Molecular; Molecular Sequence Data; Peptides; Protein Binding; Protein Structure, Tertiary; Sequence Homology, Amino Acid; Transfection | 2003 |
Differential patterns of histone methylation and acetylation distinguish active and repressed alleles at X-linked genes.
Topics: Acetylation; Alleles; Animals; Cell Line; DNA Methylation; Dosage Compensation, Genetic; Female; Gene Expression Regulation; Genetic Linkage; Histones; Hypoxanthine Phosphoribosyltransferase; Lysine; Male; Methylation; Mice; Phosphoglycerate Kinase; RNA, Long Noncoding; RNA, Untranslated; Transcription Factors; X Chromosome | 2002 |
E2F6 negatively regulates BRCA1 in human cancer cells without methylation of histone H3 on lysine 9.
Topics: Binding Sites; BRCA1 Protein; Cell Cycle Proteins; Cell Line, Tumor; Chromatin; Chromobox Protein Homolog 5; CpG Islands; E2F6 Transcription Factor; Gene Expression Regulation, Neoplastic; Histones; Humans; Lysine; Methylation; Oligonucleotide Array Sequence Analysis; Promoter Regions, Genetic; Repressor Proteins; Transcription Factors | 2003 |
Set2-catalyzed methylation of histone H3 represses basal expression of GAL4 in Saccharomyces cerevisiae.
Topics: Amino Acid Sequence; Base Sequence; Catalytic Domain; DNA-Binding Proteins; Gene Expression Regulation, Fungal; Histones; Lysine; Methylation; Methyltransferases; Molecular Sequence Data; Mutation; Protein Structure, Tertiary; Repressor Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sequence Homology, Amino Acid; Transcription Factors; Transcription, Genetic | 2003 |
Insulation of the chicken beta-globin chromosomal domain from a chromatin-condensing protein, MENT.
Topics: 3T3 Cells; Acetylation; Animals; Avian Proteins; Cell Division; Cells, Cultured; Chickens; Chromatin; Chromosomal Proteins, Non-Histone; Enzyme Inhibitors; Erythrocytes; Globins; Histone Deacetylase Inhibitors; Histones; Lymphocytes; Lysine; Methylation; Mice; Protein Structure, Tertiary | 2003 |
Identification of methylation and acetylation sites on mouse histone H3 using matrix-assisted laser desorption/ionization time-of-flight and nanoelectrospray ionization tandem mass spectrometry.
Topics: Acetylation; Amino Acid Sequence; Animals; Binding Sites; Cell Line; Histones; Lysine; Methylation; Mice; Molecular Sequence Data; Nanotechnology; Protein Processing, Post-Translational; Spectrometry, Mass, Electrospray Ionization; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2003 |
ASH1, a Drosophila trithorax group protein, is required for methylation of lysine 4 residues on histone H3.
Topics: Animals; DNA-Binding Proteins; Drosophila; Drosophila Proteins; Fluorescent Antibody Technique; Histones; Lysine; Methylation; Mutation; Transcription Factors | 2003 |
ACETYLATION AND METHYLATION OF HISTONES AND THEIR POSSIBLE ROLE IN THE REGULATION OF RNA SYNTHESIS.
Topics: Acetates; Acetylation; Amino Acids; Anti-Bacterial Agents; Arginine; Azotobacter; Carbon Isotopes; Cell Nucleus; Chromatography; Chromosomes; DNA; DNA, Bacterial; Escherichia coli; Histones; Ligases; Lysine; Metabolism; Methionine; Methylation; Methylcellulose; Proteins; Puromycin; Research; Ribosomes; RNA; RNA, Bacterial; RNA, Messenger | 1964 |
INVESTIGATION OF THE ACTIVE SITES OF LYSOZYME. CARBOXYMETHYLATION OF THE IMIDAZOLE GROUP OF HISTIDINE AND OF THE EPSILON-AMINOGROUP OF LYSINE.
Topics: Alkylation; Catalytic Domain; Chromatography; Histidine; Imidazoles; Lysine; Methylation; Muramidase; Research; Spectrophotometry | 1964 |
Antigen receptor loci poised for V(D)J rearrangement are broadly associated with BRG1 and flanked by peaks of histone H3 dimethylated at lysine 4.
Topics: Animals; DNA Helicases; Histones; Lysine; Methylation; Mice; Nuclear Proteins; Phosphorylation; Polymerase Chain Reaction; Receptors, Antigen, T-Cell; Transcription Factors; Tumor Cells, Cultured; VDJ Recombinases | 2003 |
Differential transcription factor occupancy but evolutionarily conserved chromatin features at the human and mouse M-CSF (CSF-1) receptor loci.
Topics: 3T3 Cells; Acetylation; Animals; Base Sequence; Binding Sites; Cell Line; Cell Line, Tumor; Chromatin; Conserved Sequence; Enhancer Elements, Genetic; Evolution, Molecular; HeLa Cells; Histones; HL-60 Cells; Humans; Introns; Lysine; Macrophages; Methylation; Mice; Molecular Sequence Data; Protein Binding; Receptor, Macrophage Colony-Stimulating Factor; Regulatory Sequences, Nucleic Acid; TATA-Box Binding Protein; Transcription Factors | 2003 |
mAM facilitates conversion by ESET of dimethyl to trimethyl lysine 9 of histone H3 to cause transcriptional repression.
Topics: Amino Acid Sequence; Animals; Binding Sites; Blotting, Western; Cell Line; Chromatin; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Enzymes; HeLa Cells; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; Kinetics; Lysine; Methylation; Methyltransferases; Mice; Molecular Sequence Data; Precipitin Tests; Promoter Regions, Genetic; Protein Binding; Protein Methyltransferases; Recombinant Proteins; Repressor Proteins; RNA Interference; Silver Staining; Substrate Specificity; Time Factors; Transcription Factors; Transcription, Genetic | 2003 |
Promoter-restricted H3 Lys 4 di-methylation is an epigenetic mark for monoallelic expression.
Topics: Alleles; Animals; Cells, Cultured; Chromatin; Epigenesis, Genetic; Exons; Female; Gene Expression; Histones; Lysine; Methylation; Mice; Models, Biological; Promoter Regions, Genetic | 2003 |
Methylation at lysine 4 of histone H3 in ecdysone-dependent development of Drosophila.
Topics: Animals; Chromatin Assembly and Disassembly; Drosophila; Drosophila Proteins; Ecdysone; Eye; Female; Gene Expression Regulation, Developmental; Hedgehog Proteins; Histone-Lysine N-Methyltransferase; Histones; Lysine; Male; Methylation; Promoter Regions, Genetic; Protein Binding; Receptors, Steroid | 2003 |
Dynamic methylation of histone H3 at lysine 4 in transcriptional regulation by the androgen receptor.
Topics: Androgen Receptor Antagonists; Anilides; Cell Line, Tumor; Enhancer Elements, Genetic; Exons; Histones; Humans; Kinetics; Lysine; Male; Methylation; Nitriles; Promoter Regions, Genetic; Prostate-Specific Antigen; Receptors, Androgen; RNA, Messenger; Tosyl Compounds; Transcription, Genetic; Transcriptional Activation | 2003 |
Methylation of histone H3 K4 mediates association of the Isw1p ATPase with chromatin.
Topics: Adenosine Triphosphatases; Chromatin; Chromosomal Proteins, Non-Histone; DNA-Binding Proteins; Gene Expression Regulation, Fungal; Histones; Humans; Lysine; Methionine; Methylation; mRNA Cleavage and Polyadenylation Factors; Protein Binding; RNA Polymerase II; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins | 2003 |
The N-terminal SH4 region of the Src family kinase Fyn is modified by methylation and heterogeneous fatty acylation: role in membrane targeting, cell adhesion, and spreading.
Topics: Acylation; Acyltransferases; Amino Acid Sequence; Animals; Cell Adhesion; Cell Fractionation; Cell Membrane; Chlorocebus aethiops; Consensus Sequence; COS Cells; Fatty Acids; Green Fluorescent Proteins; Luminescent Proteins; Lysine; Methylation; Myristic Acid; Palmitic Acid; Peptide Fragments; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-fyn; Recombinant Fusion Proteins; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Structure-Activity Relationship | 2004 |
Thermal stability and aggregation of sulfolobus solfataricus beta-glycosidase are dependent upon the N-epsilon-methylation of specific lysyl residues: critical role of in vivo post-translational modifications.
Topics: Amino Acids; Coloring Agents; Detergents; Dimerization; Electrophoresis, Polyacrylamide Gel; Escherichia coli; Glucosidases; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrolysis; Lysine; Mass Spectrometry; Methylation; Models, Chemical; Models, Molecular; Oxazines; Protein Binding; Protein Conformation; Protein Denaturation; Protein Processing, Post-Translational; Protein Structure, Secondary; Recombinant Proteins; Software; Spectrometry, Fluorescence; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Spectrophotometry, Infrared; Spectroscopy, Fourier Transform Infrared; Sulfolobus; Temperature | 2004 |
Histone H3 lysine 4 methylation patterns in higher eukaryotic genes.
Topics: Animals; Chickens; Chromosome Mapping; Eukaryotic Cells; Gene Expression Regulation; Genes; Genome; Globins; Histones; Lysine; Methylation; Saccharomyces cerevisiae; Transcriptional Activation | 2004 |
Silencing of transgene transcription precedes methylation of promoter DNA and histone H3 lysine 9.
Topics: Acetylation; Alpharetrovirus; Animals; Azacitidine; Cell Line; Cell Transformation, Viral; Chickens; Chromatin; CpG Islands; DNA Methylation; Erythroid Cells; Flow Cytometry; Gene Dosage; Gene Silencing; Genes, Reporter; Histones; Kinetics; Lysine; Methylation; Models, Genetic; Polymerase Chain Reaction; Precipitin Tests; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sequence Analysis, DNA; Transcription, Genetic; Transgenes | 2004 |
Partitioning and plasticity of repressive histone methylation states in mammalian chromatin.
Topics: Amino Acid Sequence; Animals; Cell Line; Chromatin; Genome; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Lysine; Mass Spectrometry; Methylation; Methyltransferases; Mice; Molecular Sequence Data; Protein Methyltransferases; Repressor Proteins | 2003 |
Histone methyltransferases direct different degrees of methylation to define distinct chromatin domains.
Topics: Animals; Cells, Cultured; Chromatin; Fibroblasts; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Methyltransferases; Mice; Protein Methyltransferases; Repressor Proteins; Transcription, Genetic | 2003 |
Two distinct methods analyzing chromatin structure using centrifugation and antibodies to modified histone H3: both provide similar chromatin states of the Rit1/Bcl11b gene.
Topics: Animals; Antibodies; Blotting, Northern; Blotting, Western; Cell Division; Cell Line, Tumor; Centrifugation; Chromatin; DNA; Histones; Liver; Lysine; Methylation; Mice; Models, Genetic; Polymerase Chain Reaction; Precipitin Tests; ras Proteins; Thymus Gland; Tissue Distribution | 2004 |
Allylation and propargylation of chiral cyanopropanoates: an efficient route to long chain alpha-substituted alpha-methyl alpha-amino acids.
Topics: Cyanates; Fatty Acids; Lysine; Methylation; Molecular Structure; Stereoisomerism | 2004 |
Differentiation between peptides containing acetylated or tri-methylated lysines by mass spectrometry: an application for determining lysine 9 acetylation and methylation of histone H3.
Topics: Acetylation; Histones; Lysine; Methylation; Peptides; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2004 |
Histone H3 lysine 9 methylation is required for DNA elimination in developing macronuclei in Tetrahymena.
Topics: Animals; Fluorescent Antibody Technique, Indirect; Histones; Lysine; Methylation; Nuclear Proteins; Phosphoproteins; Protozoan Proteins; RNA, Protozoan; Tetrahymena thermophila | 2004 |
FGF2-induced chromatin remodeling regulates CNTF-mediated gene expression and astrocyte differentiation.
Topics: Animals; Astrocytes; Cell Differentiation; Cells, Cultured; Cerebral Cortex; Chromatin Assembly and Disassembly; Ciliary Neurotrophic Factor; DNA-Binding Proteins; Fetus; Fibroblast Growth Factor 2; Gene Expression Regulation, Developmental; Glial Fibrillary Acidic Protein; Histones; Lysine; Methylation; Promoter Regions, Genetic; Rats; Signal Transduction; STAT1 Transcription Factor; Stem Cells; Trans-Activators; Transcription Factors | 2004 |
Structure of the scorpion toxin BmBKTtx1 solved from single wavelength anomalous scattering of sulfur.
Topics: Amino Acid Sequence; Amino Acids; Animals; Crystallography, X-Ray; Cysteine; Disulfides; Electrons; Insect Proteins; Lysine; Methylation; Models, Molecular; Molecular Sequence Data; Neurotoxins; Potassium Channels; Protein Conformation; Protein Folding; Scattering, Radiation; Scorpion Venoms; Scorpions; Static Electricity; Sulfur; X-Rays | 2004 |
The ionic track in the F1-ATPase from the thermophilic Bacillus PS3.
Topics: Adenosine Diphosphate; Amino Acid Substitution; Arginine; Bacillus; Bacterial Proton-Translocating ATPases; Catalytic Domain; Copper; Cysteine; Enzyme Activation; Enzyme Inhibitors; Glutamic Acid; Lysine; Methylation; Mutagenesis, Site-Directed; Protein Subunits; Sodium-Potassium-Exchanging ATPase; Temperature | 2004 |
The essential WD repeat protein Swd2 has dual functions in RNA polymerase II transcription termination and lysine 4 methylation of histone H3.
Topics: Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Phenotype; RNA Polymerase II; RNA-Binding Proteins; RNA, Messenger; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Temperature; Transcription, Genetic | 2004 |
The N-terminus of Drosophila SU(VAR)3-9 mediates dimerization and regulates its methyltransferase activity.
Topics: Amino Acid Sequence; Animals; Catalysis; Dimerization; Drosophila melanogaster; Drosophila Proteins; Enzyme Activation; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Isoenzymes; Kinetics; Lysine; Methylation; Methyltransferases; Molecular Sequence Data; Peptide Fragments; Protein Binding; Protein Methyltransferases; Protein Processing, Post-Translational; Recombinant Proteins; Sequence Deletion | 2004 |
Histone 3 lysine 4 methylation during the pre-B to immature B-cell transition.
Topics: Animals; B-Lymphocytes; Cell Line, Transformed; Cell Lineage; Cells, Cultured; Gene Rearrangement, B-Lymphocyte; Histones; Immunoglobulin kappa-Chains; Lysine; Methylation; Stem Cells | 2004 |
Small molecule regulators of protein arginine methyltransferases.
Topics: Arginine; Binding Sites; Cell Line, Tumor; Cell Nucleus; DNA Methylation; Enzyme-Linked Immunosorbent Assay; Epitopes; Genes, Reporter; Glutathione Transferase; Green Fluorescent Proteins; Humans; Inhibitory Concentration 50; Light; Luciferases; Luminescent Proteins; Lysine; Methylation; Models, Chemical; Nitrogen; Plasmids; Protein Processing, Post-Translational; Protein Structure, Tertiary; Protein Transport; Protein-Arginine N-Methyltransferases; S-Adenosylmethionine; Signal Transduction; Transcription, Genetic; Transcriptional Activation; Transfection; Ultraviolet Rays | 2004 |
Gene-specific modulation of TAF10 function by SET9-mediated methylation.
Topics: Amino Acid Sequence; Antibodies, Monoclonal; Baculoviridae; Binding Sites; Cell Line; Cell Nucleus; Escherichia coli; Gene Expression Regulation; Genes, Reporter; Genetic Vectors; HeLa Cells; Histones; Humans; Lysine; Methylation; Methyltransferases; Mutation; Nucleosomes; Precipitin Tests; Protein Structure, Tertiary; Proteins; Recombinant Fusion Proteins; RNA Polymerase II; Substrate Specificity; TATA-Binding Protein Associated Factors; Time Factors; Transcription Factor TFIID; Transcription, Genetic; Transcriptional Activation | 2004 |
Regulation of histone H3 lysine 9 methylation in oocytes and early pre-implantation embryos.
Topics: Animals; Blastula; Body Patterning; Female; Fertilization; Fertilization in Vitro; Genome; Histones; Homeostasis; Lysine; Male; Methylation; Mice; Mice, Inbred Strains; Oocytes; Parthenogenesis; Sex Characteristics; Zygote Intrafallopian Transfer | 2004 |
Tethering of HP1 proteins to chromatin is relieved by phosphoacetylation of histone H3.
Topics: Acetylation; Animals; Chromatin; Chromobox Protein Homolog 5; Chromosomal Proteins, Non-Histone; G2 Phase; Gene Expression Regulation; Histones; Lysine; Macromolecular Substances; Methylation; Mice; Mitosis; NIH 3T3 Cells; Peptides; Phosphorylation; Protein Binding; Recombinant Fusion Proteins; Serine; Surface Plasmon Resonance | 2004 |
Heterochromatin and tri-methylated lysine 20 of histone H4 in animals.
Topics: Animals; Cell Line; Cell Nucleus; Cells, Cultured; Centromere; Chromosomes; Culture Media, Serum-Free; DNA; Drosophila; Embryo, Mammalian; Embryo, Nonmammalian; Female; Fibroblasts; Fluorescent Antibody Technique, Indirect; Genetic Markers; Hemiptera; Heterochromatin; Histones; Lysine; Male; Methylation; Mice; Microscopy, Fluorescence; Oocytes; S Phase; Spermatozoa; Telomere | 2004 |
Genetically encoded fluorescent reporters of histone methylation in living cells.
Topics: Animals; Cells; Escherichia coli; Fluorescent Dyes; Genes, Reporter; Histones; Lysine; Methylation; Molecular Sequence Data; Mutagenesis, Site-Directed; Paramecium; Protein Processing, Post-Translational | 2004 |
Three dimensional analysis of histone methylation patterns in normal and tumor cell nuclei.
Topics: Cell Line, Tumor; Cell Nucleus; Centromere; DNA; Female; Fibroblasts; Heterochromatin; Histones; Humans; Lysine; Methylation; Monocytes; Neoplasms; T-Lymphocytes | 2004 |
A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin.
Topics: Amino Acid Sequence; Animals; Cells, Cultured; Chromobox Protein Homolog 5; Chromosomal Proteins, Non-Histone; Conserved Sequence; Drosophila; Drosophila Proteins; Female; Fibroblasts; Gene Silencing; Genes, Suppressor; Heterochromatin; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Lysine; Mammals; Methylation; Methyltransferases; Mice; Molecular Sequence Data; Protein Methyltransferases; Protein Structure, Tertiary; Repressor Proteins; Substrate Specificity | 2004 |
Functions for S. cerevisiae Swd2p in 3' end formation of specific mRNAs and snoRNAs and global histone 3 lysine 4 methylation.
Topics: Amino Acid Sequence; Base Sequence; DNA-Binding Proteins; DNA, Fungal; Histone-Lysine N-Methyltransferase; Histones; Lysine; Macromolecular Substances; Methylation; Molecular Sequence Data; mRNA Cleavage and Polyadenylation Factors; Multiprotein Complexes; Repetitive Sequences, Amino Acid; RNA, Fungal; RNA, Messenger; RNA, Small Nucleolar; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sequence Homology, Amino Acid; Transcription Factors | 2004 |
K8 and K12 are biotinylated in human histone H4.
Topics: Acetylation; Amino Acid Substitution; Antibodies; Biotinylation; Chromatography, High Pressure Liquid; Histones; Humans; Jurkat Cells; Lysine; Mass Spectrometry; Methylation; Peptides | 2004 |
A possible involvement of the carboxymethylation process in carpal tunnel syndrome in hemodialysis patients.
Topics: Adult; Age of Onset; Aged; Carpal Tunnel Syndrome; Electrophysiology; Female; Hemoglobins; Humans; Lysine; Male; Methylation; Middle Aged; Multivariate Analysis; Neural Conduction; Regression Analysis; Renal Dialysis; Time Factors | 2004 |
Differential histone H3 Lys-9 and Lys-27 methylation profiles on the X chromosome.
Topics: Animals; Cells, Cultured; Dosage Compensation, Genetic; Female; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Kinetics; Lysine; Male; Methylation; Mice; Mutation; Protein Methyltransferases; RNA, Long Noncoding; RNA, Untranslated; X Chromosome | 2004 |
Effectors of lysine 4 methylation of histone H3 in Saccharomyces cerevisiae are negative regulators of PHO5 and GAL1-10.
Topics: Acid Phosphatase; Carrier Proteins; DNA-Binding Proteins; Feedback, Physiological; Gene Deletion; Gene Expression Regulation; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Mutagenesis; Nuclear Proteins; Polymerase Chain Reaction; Proton-Phosphate Symporters; RNA, Messenger; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; TATA-Box Binding Protein; Transcription Factors; Transcription, Genetic; Ubiquitin; Ubiquitin-Conjugating Enzymes | 2004 |
A switch in mitotic histone H4 lysine 20 methylation status is linked to M phase defects upon loss of HCF-1.
Topics: Cell Division; Cell Line, Tumor; Chromatin; Cytokinesis; HeLa Cells; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Host Cell Factor C1; Humans; Lysine; Methylation; Mitosis; Protein Methyltransferases; RNA, Messenger; RNA, Small Interfering; Transcription Factors; Up-Regulation | 2004 |
Human DNA methyltransferase 1 is required for maintenance of the histone H3 modification pattern.
Topics: Animals; Base Sequence; Cell Line, Tumor; Cell Nucleus; Chromatin; Chromobox Protein Homolog 5; Chromosomal Proteins, Non-Histone; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Electrophoresis, Capillary; Heterochromatin; Histone Deacetylases; Histones; Humans; Lysine; Methylation; Mice; Micrococcal Nuclease; Microscopy, Electron; Microscopy, Fluorescence; Molecular Sequence Data; Phenotype; Precipitin Tests; Protein Binding | 2004 |
SUZ12 is required for both the histone methyltransferase activity and the silencing function of the EED-EZH2 complex.
Topics: Binding Sites; Cell Division; DNA-Binding Proteins; Enhancer of Zeste Homolog 2 Protein; Gene Expression Regulation, Developmental; Gene Silencing; Gene Targeting; Genes, Homeobox; HeLa Cells; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Homeodomain Proteins; Humans; Lysine; Methylation; Mutation; Neoplasm Proteins; Polycomb Repressive Complex 2; Protein Methyltransferases; Proteins; Repressor Proteins; Silencer Elements, Transcriptional; Transcription Factors; Up-Regulation | 2004 |
Silencing of human polycomb target genes is associated with methylation of histone H3 Lys 27.
Topics: Carrier Proteins; Colonic Neoplasms; CpG Islands; DNA-Binding Proteins; Enhancer of Zeste Homolog 2 Protein; Gene Expression Regulation; Gene Silencing; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Macromolecular Substances; Methylation; Neoplasm Proteins; Nuclear Proteins; Oligonucleotide Array Sequence Analysis; Polycomb Repressive Complex 2; Polycomb-Group Proteins; Promoter Regions, Genetic; Proteins; Repressor Proteins; Transcription Factors | 2004 |
A chromosomal memory triggered by Xist regulates histone methylation in X inactivation.
Topics: Animals; Blotting, Western; Cell Differentiation; Chromatin; Chromatin Immunoprecipitation; DNA; DNA Methylation; Dosage Compensation, Genetic; Embryo, Mammalian; Gene Silencing; Histones; In Situ Hybridization, Fluorescence; Kinetics; Lysine; Methylation; Mice; Microscopy, Fluorescence; Models, Biological; Models, Genetic; Mutation; RNA; RNA, Long Noncoding; RNA, Untranslated; Stem Cells; X Chromosome; X Chromosome Inactivation | 2004 |
B cell-specific loss of histone 3 lysine 9 methylation in the V(H) locus depends on Pax5.
Topics: Animals; B-Lymphocytes; Base Sequence; Cell Lineage; Cells, Cultured; DNA-Binding Proteins; Flow Cytometry; Gene Rearrangement, B-Lymphocyte; Hematopoietic Stem Cells; Histones; Immunoglobulin Heavy Chains; Immunoglobulin Variable Region; Lysine; Methylation; Mice; Models, Immunological; Molecular Sequence Data; PAX5 Transcription Factor; Precipitin Tests; Reverse Transcriptase Polymerase Chain Reaction; Transcription Factors | 2004 |
RNAi-dependent and RNAi-independent mechanisms contribute to the silencing of RIPed sequences in Neurospora crassa.
Topics: DNA Transposable Elements; DNA, Fungal; Gene Expression Regulation, Fungal; Gene Silencing; Genome, Fungal; Histones; Lysine; Methylation; Neurospora crassa; Point Mutation; Repetitive Sequences, Nucleic Acid; RNA Interference; RNA, Fungal; RNA, Small Interfering | 2004 |
Dynamic alterations of specific histone modifications during early murine development.
Topics: Acetylation; Animals; Arginine; Embryo, Mammalian; Female; Fluorescent Antibody Technique, Indirect; Histones; Hydrolases; Lysine; Metaphase; Methylation; Mice; Microscopy, Confocal; Oocytes; Phosphorylation; Protein-Arginine Deiminases; Serine | 2004 |
Methyl-CpG binding protein MBD1 couples histone H3 methylation at lysine 9 by SETDB1 to DNA replication and chromatin assembly.
Topics: Apoptosis Regulatory Proteins; Carrier Proteins; Chromatin Assembly and Disassembly; CpG Islands; DNA Replication; DNA-Binding Proteins; Gene Silencing; HeLa Cells; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Macromolecular Substances; Methylation; Models, Biological; Promoter Regions, Genetic; Protein Methyltransferases; Proteins; RNA, Small Interfering; S Phase; Transcription Factors; Two-Hybrid System Techniques | 2004 |
During lytic infection herpes simplex virus type 1 is associated with histones bearing modifications that correlate with active transcription.
Topics: Base Sequence; Cell Line; DNA, Viral; Genome, Viral; Herpesvirus 1, Human; Histones; Humans; Lysine; Methylation; Micrococcal Nuclease; Models, Biological; Nucleosomes; Promoter Regions, Genetic; Transcription, Genetic | 2004 |
Characterization of the grappa gene, the Drosophila histone H3 lysine 79 methyltransferase.
Topics: Animals; Drosophila melanogaster; Drosophila Proteins; Embryonic Development; Female; Gene Expression Regulation, Developmental; Gene Silencing; Genes, Dominant; Heterochromatin; Histone-Lysine N-Methyltransferase; Histones; Homeodomain Proteins; Lysine; Male; Methylation; Mutation; Nuclear Proteins; Phenotype; Polycomb Repressive Complex 1; Repressor Proteins; Saccharomyces cerevisiae Proteins; Telomere | 2005 |
A mass spectrometric "Western blot" to evaluate the correlations between histone methylation and histone acetylation.
Topics: Acetic Acid; Acetylation; Blotting, Western; Chromatin; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Chromatography, Liquid; Electrophoresis, Polyacrylamide Gel; HeLa Cells; Histones; Humans; Lysine; Mass Spectrometry; Methylation; Peptides; Phosphorylation; Protein Processing, Post-Translational; Protein Structure, Tertiary; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Transcription, Genetic; Urea | 2004 |
Differential dynamics of histone H3 methylation at positions K4 and K9 in the mouse zygote.
Topics: Animals; Chromosomal Instability; Chromosomes, Mammalian; Crosses, Genetic; Female; Fertilization in Vitro; Fluorescent Antibody Technique, Indirect; Genome; Histones; Lysine; Male; Methylation; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Microscopy, Fluorescence; Oocytes; Pregnancy; Spermatozoa; Time Factors; Zygote | 2004 |
Histone H4 hyperacetylation precludes histone H4 lysine 20 trimethylation.
Topics: Acetamides; Acetylation; Amino Acid Sequence; Animals; Antineoplastic Agents; Blotting, Western; Butyrates; Cell Differentiation; Cell Line, Tumor; Cell Nucleus; Chromatin; Chromatography, High Pressure Liquid; Chromatography, Liquid; Dimethyl Sulfoxide; Enzyme Inhibitors; Heterochromatin; Histones; Hydroxamic Acids; Leukemia, Erythroblastic, Acute; Lysine; Mass Spectrometry; Metalloendopeptidases; Methylation; Mice; Microscopy, Fluorescence; Molecular Sequence Data; Peptides; Protein Processing, Post-Translational; Sodium Oxybate; Time Factors; Transcription, Genetic | 2004 |
Dual histone H3 methylation marks at lysines 9 and 27 required for interaction with CHROMOMETHYLASE3.
Topics: Amino Acid Sequence; Animals; Arabidopsis; Arabidopsis Proteins; Chromosomal Proteins, Non-Histone; DNA-Cytosine Methylases; Epigenesis, Genetic; Gene Expression Regulation, Plant; Gene Silencing; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Methyltransferases; Models, Genetic; Molecular Sequence Data; Protein Binding; Sequence Alignment | 2004 |
Ligand-dependent activation of the farnesoid X-receptor directs arginine methylation of histone H3 by CARM1.
Topics: Acetylation; Arginine; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Binding Sites; Blotting, Western; Cell Line; Chromatin; DNA; DNA-Binding Proteins; Drug Synergism; Electrophoresis, Polyacrylamide Gel; Histones; Humans; Immunosorbent Techniques; Lysine; Methylation; Promoter Regions, Genetic; Protein-Arginine N-Methyltransferases; Receptors, Cytoplasmic and Nuclear; RNA, Messenger; Signal Transduction; Transcription Factors; Transfection | 2004 |
Substrate specificity and kinetic mechanism of mammalian G9a histone H3 methyltransferase.
Topics: Alanine; Animals; Baculoviridae; Binding, Competitive; Catalysis; Cell Line; Dimerization; Dose-Response Relationship, Drug; Genetic Vectors; Genome; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Homocysteine; Hydrogen-Ion Concentration; Insecta; Kinetics; Lysine; Mass Spectrometry; Methylation; Mice; Models, Chemical; Models, Genetic; Peptides; Phosphorylation; Protein Isoforms; Protein Methyltransferases; Recombinant Proteins; Substrate Specificity; Temperature; Time Factors | 2004 |
Human SWI/SNF-associated PRMT5 methylates histone H3 arginine 8 and negatively regulates expression of ST7 and NM23 tumor suppressor genes.
Topics: Acetylation; Animals; Arginine; Cell Division; Cell Line; Chromosomal Proteins, Non-Histone; DNA Helicases; Gene Expression Regulation; Genes, Tumor Suppressor; Histones; Humans; Lysine; Methylation; Mice; NM23 Nucleoside Diphosphate Kinases; Nuclear Proteins; Nucleoside-Diphosphate Kinase; Promoter Regions, Genetic; Protein Methyltransferases; Protein-Arginine N-Methyltransferases; Transcription Factors; Tumor Suppressor Proteins | 2004 |
Using LC-MS with de novo software to fully characterize the multiple methylations of lysine residues in a recombinant fragment of an outer membrane protein from a virulent strain of Rickettsia prowazekii.
Topics: Amino Acid Sequence; Animals; Bacterial Outer Membrane Proteins; Humans; Lysine; Mass Spectrometry; Methylation; Molecular Sequence Data; Peptide Fragments; Protein Processing, Post-Translational; Recombinant Proteins; Rickettsia prowazekii; Sequence Analysis, Protein; Software | 2004 |
Histone hypomethylation is an indicator of epigenetic plasticity in quiescent lymphocytes.
Topics: Animals; B-Lymphocytes; Blotting, Western; Cells, Cultured; Chromatin; Chromatin Immunoprecipitation; Epigenesis, Genetic; Gene Expression Regulation; Gene Silencing; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Kinetics; Lysine; Methylation; Mice; Mice, Transgenic; Microscopy, Confocal; Protein Methyltransferases; Resting Phase, Cell Cycle; Reverse Transcriptase Polymerase Chain Reaction; T-Lymphocytes; Up-Regulation | 2004 |
The Polycomb Ezh2 methyltransferase regulates muscle gene expression and skeletal muscle differentiation.
Topics: Animals; Cell Differentiation; Chromatin; DNA-Binding Proteins; Enhancer of Zeste Homolog 2 Protein; Erythroid-Specific DNA-Binding Factors; Extremities; Gene Expression Regulation, Developmental; Histone Deacetylase 1; Histone Deacetylases; Histone-Lysine N-Methyltransferase; Lysine; Methylation; Methyltransferases; Mice; Mice, Inbred Strains; Muscle, Skeletal; MyoD Protein; Polycomb Repressive Complex 2; Protein Structure, Tertiary; Proteins; Regulatory Sequences, Nucleic Acid; RNA, Small Interfering; Serum Response Factor; Transcription Factors; Transcriptional Activation; YY1 Transcription Factor | 2004 |
Regulation of p53 activity through lysine methylation.
Topics: Amino Acid Sequence; Apoptosis; Cell Line; Cell Nucleus; Gene Expression Regulation; Genes, p53; Genes, ras; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Humans; Lysine; Methylation; Models, Molecular; Molecular Sequence Data; Promoter Regions, Genetic; Protein Binding; Protein Conformation; Protein Methyltransferases; RNA, Messenger; S-Adenosylhomocysteine; Substrate Specificity; Thermodynamics; Tumor Suppressor Protein p53 | 2004 |
Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks.
Topics: Amino Acid Sequence; Binding Sites; Cell Line, Tumor; Chromatin; Conserved Sequence; Cross-Linking Reagents; DNA; DNA Damage; Histone-Lysine N-Methyltransferase; Histones; Humans; Intracellular Signaling Peptides and Proteins; Lysine; Methylation; Methyltransferases; Models, Molecular; Molecular Sequence Data; Phosphoproteins; Protein Binding; Protein Structure, Tertiary; Tumor Suppressor p53-Binding Protein 1 | 2004 |
Chemotherapy for the brain: the antitumor antibiotic mithramycin prolongs survival in a mouse model of Huntington's disease.
Topics: Animals; Antibiotics, Antineoplastic; Brain; Cells, Cultured; Gene Silencing; Humans; Huntingtin Protein; Huntington Disease; In Vitro Techniques; Lysine; Male; Methylation; Mice; Mice, Transgenic; Mitochondria, Liver; Motor Activity; N-Methylaspartate; Nerve Tissue Proteins; Neurons; Nuclear Proteins; Plicamycin; Rats; Rats, Inbred BN; Rats, Inbred F344; Receptors, Glutamate; Transcription, Genetic | 2004 |
Methylation of histone H4 lysine 20 controls recruitment of Crb2 to sites of DNA damage.
Topics: Cell Cycle Proteins; Cell Survival; DNA Damage; Gene Expression Regulation, Fungal; Genes, cdc; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Intracellular Signaling Peptides and Proteins; Lysine; Methylation; Mutation; Nuclear Proteins; Phosphoproteins; Protein Methyltransferases; Protein Transport; Schizosaccharomyces; Schizosaccharomyces pombe Proteins | 2004 |
Distinct dynamics and distribution of histone methyl-lysine derivatives in mouse development.
Topics: Animals; Cell Differentiation; Cells, Cultured; Embryo, Mammalian; Embryonic Structures; Gene Expression Regulation, Developmental; Gestational Age; Histones; Lysine; Methylation; Mice; Muscle, Skeletal; Myoblasts; Neurons | 2004 |
Developmentally regulated alterations in Polycomb repressive complex 1 proteins on the inactive X chromosome.
Topics: Animals; Carrier Proteins; Cell Line; Dosage Compensation, Genetic; Drosophila; Drosophila Proteins; Female; Histones; Humans; Kinetics; Lysine; Macromolecular Substances; Methylation; Mice; Polycomb Repressive Complex 1; Polycomb-Group Proteins; Repressor Proteins; Species Specificity; X Chromosome | 2004 |
Histone demethylation mediated by the nuclear amine oxidase homolog LSD1.
Topics: Conserved Sequence; Formaldehyde; Gene Expression Regulation; HeLa Cells; Histone Demethylases; Histones; Humans; Lysine; Mass Spectrometry; Methylation; Nuclear Proteins; Oxidoreductases, N-Demethylating; Recombinant Proteins; Repressor Proteins; RNA Interference; Schizosaccharomyces pombe Proteins; Substrate Specificity; Transcription, Genetic | 2004 |
The DNA damage checkpoint response requires histone H2B ubiquitination by Rad6-Bre1 and H3 methylation by Dot1.
Topics: Binding Sites; Blotting, Western; Cell Cycle; Cell Cycle Proteins; Cell Separation; Checkpoint Kinase 2; Chromatin; DNA Damage; Electrophoresis, Polyacrylamide Gel; Enzyme Activation; Flow Cytometry; Histone-Lysine N-Methyltransferase; Histones; Intracellular Signaling Peptides and Proteins; Lysine; Methylation; Nuclear Proteins; Phosphorylation; Plasmids; Protein Serine-Threonine Kinases; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Serine; Time Factors; Ubiquitin; Ubiquitin-Conjugating Enzymes; Ultraviolet Rays | 2005 |
S-adenosylhomocysteine hydrolase from the archaeon Pyrococcus furiosus: biochemical characterization and analysis of protein structure by comparative molecular modeling.
Topics: Adenosine; Adenosylhomocysteinase; Amino Acid Sequence; Catalysis; Cloning, Molecular; Cysteine; Disulfides; Electrophoresis, Polyacrylamide Gel; Homocysteine; Hot Temperature; Kinetics; Lysine; Methylation; Models, Molecular; Molecular Sequence Data; Plasmids; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Pyrococcus; Pyrococcus furiosus; Recombinant Proteins; Sequence Homology, Amino Acid; Sulfolobus solfataricus; Temperature; Threonine | 2005 |
Chd1 chromodomain links histone H3 methylation with SAGA- and SLIK-dependent acetylation.
Topics: Acetylation; Acetyltransferases; Amino Acid Sequence; Chromatin Immunoprecipitation; DNA-Binding Proteins; Gene Deletion; Histone Acetyltransferases; Histones; Lysine; Methylation; Molecular Sequence Data; Multiprotein Complexes; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Substrate Specificity | 2005 |
The ESC-E(Z) complex participates in the hedgehog signaling pathway.
Topics: Amino Acid Sequence; Animals; Fish Proteins; Gene Expression Regulation, Developmental; Hedgehog Proteins; Histones; Humans; Hydroxamic Acids; Lysine; Methylation; Molecular Sequence Data; Multiprotein Complexes; Oryzias; Phenotype; Phylogeny; Protein Binding; Sequence Alignment; Signal Transduction; Trans-Activators | 2005 |
Genomic maps and comparative analysis of histone modifications in human and mouse.
Topics: Acetylation; Animals; Chromatin; Chromosome Mapping; Chromosomes, Human, Pair 21; Chromosomes, Human, Pair 22; Genome; Histones; Homeodomain Proteins; Humans; Lysine; Methylation; Mice; Receptors, Interleukin-4 | 2005 |
PR-Set7-dependent methylation of histone H4 Lys 20 functions in repression of gene expression and is essential for mitosis.
Topics: Animals; Blotting, Western; Drosophila; Drosophila Proteins; Gene Silencing; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Mitosis | 2005 |
Maintenance of low histone ubiquitylation by Ubp10 correlates with telomere-proximal Sir2 association and gene silencing.
Topics: Acetylation; Chromatin Immunoprecipitation; DNA, Ribosomal; Down-Regulation; Gene Expression Regulation, Fungal; Gene Silencing; Histone Deacetylases; Histones; Lysine; Methylation; Nuclear Proteins; Proteasome Endopeptidase Complex; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Silent Information Regulator Proteins, Saccharomyces cerevisiae; Sirtuin 2; Sirtuins; Telomere; Transcription, Genetic; Transcriptional Activation; Ubiquitin; Ubiquitin Thiolesterase | 2005 |
Nuclear proteasome activation and degradation of carboxymethylated histones in human keratinocytes following glyoxal treatment.
Topics: Blotting, Western; Cell Line; Cell Nucleus; Cell Proliferation; Chromatography, High Pressure Liquid; Cycloheximide; Cysteine Endopeptidases; Dose-Response Relationship, Drug; Glycols; Glyoxal; Histones; Humans; Keratinocytes; Lysine; Methylation; Models, Biological; Oxidative Stress; Oxygen; Poly(ADP-ribose) Polymerases; Proteasome Endopeptidase Complex; Protein Synthesis Inhibitors; Time Factors | 2005 |
Relationship between histone H3 lysine 9 methylation, transcription repression, and heterochromatin protein 1 recruitment.
Topics: Acetylation; Chromatin; Chromobox Protein Homolog 5; Chromosomal Proteins, Non-Histone; Gene Silencing; Histones; Humans; Lysine; Methylation; Transcription, Genetic | 2005 |
Histone methyltransferases G9a and GLP form heteromeric complexes and are both crucial for methylation of euchromatin at H3-K9.
Topics: Animals; Euchromatin; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Mice; Protein Methyltransferases; Protein Structure, Quaternary; Stem Cells | 2005 |
Differential subnuclear localization and replication timing of histone H3 lysine 9 methylation states.
Topics: Animals; Antibodies, Monoclonal; Cell Line, Tumor; Cell Nucleus; CHO Cells; Cricetinae; Cricetulus; DNA; Epigenesis, Genetic; Epitopes; Fluorescent Dyes; Heterochromatin; Histone-Lysine N-Methyltransferase; Histones; Humans; Indoles; Lysine; Methylation; Mice; Microscopy, Confocal; S Phase | 2005 |
A novel domain in Set2 mediates RNA polymerase II interaction and couples histone H3 K36 methylation with transcript elongation.
Topics: Alleles; Amino Acid Substitution; Chromatin; Chromatin Immunoprecipitation; Conserved Sequence; Histones; Lysine; Methylation; Methyltransferases; Protein Interaction Mapping; Protein Structure, Tertiary; RNA Polymerase II; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sequence Deletion; Transcription, Genetic; Uracil | 2005 |
Histone demethylation catalysed by LSD1 is a flavin-dependent oxidative process.
Topics: Catalysis; Flavins; Histone Demethylases; Histones; Lysine; Methylation; Oxidation-Reduction; Oxidoreductases, N-Demethylating; Substrate Specificity | 2005 |
RNA helicase A is important for germline transcriptional control, proliferation, and meiosis in C. elegans.
Topics: Animals; Autoantigens; Caenorhabditis elegans; Cell Death; Cell Proliferation; Chromatin; DEAD-box RNA Helicases; Gene Deletion; Gene Expression Regulation, Developmental; Gene Silencing; Histones; Immunohistochemistry; In Situ Hybridization; Lysine; Meiosis; Methylation; Mitosis; Models, Genetic; Neoplasm Proteins; Phenotype; Reverse Transcriptase Polymerase Chain Reaction; RNA; RNA Helicases; Temperature; Transcription, Genetic | 2005 |
Are STATS arginine-methylated?
Topics: Animals; Arginine; Blotting, Western; Cell Line, Tumor; DNA-Binding Proteins; Extracellular Signal-Regulated MAP Kinases; Fibrosarcoma; Gene Expression Regulation, Neoplastic; Genes, Reporter; Glutathione Transferase; Humans; Immunoprecipitation; Interferon-alpha; Interferons; Interleukin-6; Lysine; Melanoma; Methylation; Methyltransferases; Mice; Models, Molecular; Mutagenesis, Site-Directed; Mutation; Oncostatin M; p38 Mitogen-Activated Protein Kinases; Peptides; Phosphatidylinositol 3-Kinases; Plasmids; Protein Structure, Tertiary; Receptors, Interleukin-6; Recombinant Fusion Proteins; Recombinant Proteins; Signal Transduction; STAT1 Transcription Factor; STAT3 Transcription Factor; Trans-Activators; Transfection; Tyrosine | 2005 |
Small interfering RNAs that trigger posttranscriptional gene silencing are not required for the histone H3 Lys9 methylation necessary for transgenic tandem repeat stabilization in Neurospora crassa.
Topics: Chromatin Immunoprecipitation; Gene Expression Regulation, Fungal; Genes, Fungal; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Mutation; Neurospora crassa; Protein Methyltransferases; RNA Interference; RNA, Small Interfering; Tandem Repeat Sequences; Transcription, Genetic; Transgenes | 2005 |
Transcriptional silencing of nonsense codon-containing immunoglobulin minigenes.
Topics: Base Sequence; Codon, Nonsense; Exonucleases; Gene Silencing; Genes, Immunoglobulin; Genes, Reporter; HeLa Cells; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Humans; Immunoglobulins; Lysine; Methylation; RNA Interference; Sequence Alignment; Transcription, Genetic | 2005 |
The expression of endothelial nitric-oxide synthase is controlled by a cell-specific histone code.
Topics: Acetylation; Animals; Azacitidine; beta-Galactosidase; Blotting, Western; Cell Line; Cell Nucleus; Cells, Cultured; Chromatin; Chromatin Immunoprecipitation; CpG Islands; DNA Methylation; Endothelium, Vascular; HeLa Cells; Histones; Humans; Hydroxamic Acids; Lysine; Methylation; Mice; Mice, Transgenic; Models, Genetic; Muscle, Smooth; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nucleosomes; Promoter Regions, Genetic; Protein Binding; Protein Structure, Tertiary; Reverse Transcriptase Polymerase Chain Reaction; RNA Polymerase II; Serine; Time Factors; Transgenes; Umbilical Veins | 2005 |
In vivo HP1 targeting causes large-scale chromatin condensation and enhanced histone lysine methylation.
Topics: Cells, Cultured; Chromobox Protein Homolog 5; Chromosomal Proteins, Non-Histone; Chromosomes, Human; Gene Silencing; Green Fluorescent Proteins; Heterochromatin; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Operator Regions, Genetic; Protein Methyltransferases; Recombinant Fusion Proteins; Repressor Proteins | 2005 |
Mapping global histone methylation patterns in the coding regions of human genes.
Topics: Euchromatin; Gene Silencing; Genome, Human; Heterochromatin; Histones; Humans; Lysine; Methylation; Oligonucleotide Array Sequence Analysis; Open Reading Frames | 2005 |
The murine polycomb group protein Eed is required for global histone H3 lysine-27 methylation.
Topics: Animals; Blotting, Northern; Blotting, Western; Cloning, Molecular; Embryo, Mammalian; Epigenesis, Genetic; Fluorescent Antibody Technique; Gene Silencing; Genetic Vectors; Histones; Lysine; Methylation; Mice; Polycomb Repressive Complex 2; Repressor Proteins; Reverse Transcriptase Polymerase Chain Reaction; Stem Cells | 2005 |
Asymmetry in histone H3 variants and lysine methylation between paternal and maternal chromatin of the early mouse zygote.
Topics: Animals; Cell Cycle Proteins; Chromatin; Epigenesis, Genetic; Epitope Mapping; Female; Fertilization; Fluorescent Antibody Technique; Genetic Variation; Histone Chaperones; Histones; Lysine; Male; Methylation; Mice; Mice, Inbred CBA; Nucleosomes; Pregnancy; Protamines; Spermatozoa; Transcription Factors; Zygote | 2005 |
Functional analysis of the N- and C-terminus of mammalian G9a histone H3 methyltransferase.
Topics: Amino Acid Sequence; Animals; Cell Nucleus; DNA Mutational Analysis; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Mice; Molecular Sequence Data; Nuclear Localization Signals; Protein Methyltransferases; Protein Structure, Tertiary | 2005 |
Dynamic lysine methylation on histone H3 defines the regulatory phase of gene transcription.
Topics: DNA, Fungal; Gene Expression Regulation; Histones; Kinetics; Lysine; Methylation; Oligonucleotide Array Sequence Analysis; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Transcription, Genetic | 2005 |
WDR5 associates with histone H3 methylated at K4 and is essential for H3 K4 methylation and vertebrate development.
Topics: Animals; Cell Line; Genes, Homeobox; Heterotrimeric GTP-Binding Proteins; Histone-Lysine N-Methyltransferase; Histones; Humans; Intracellular Signaling Peptides and Proteins; Lysine; Macromolecular Substances; Methylation; Microfilament Proteins; Nucleosomes; Vertebrates; Xenopus laevis | 2005 |
Global loss of Set1-mediated H3 Lys4 trimethylation is associated with silencing defects in Saccharomyces cerevisiae.
Topics: Base Sequence; Cell Division; DNA Primers; DNA-Binding Proteins; DNA, Fungal; DNA, Recombinant; Gene Silencing; Histone-Lysine N-Methyltransferase; Lysine; Methylation; Peptide Fragments; Plasmids; Protein Processing, Post-Translational; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Transcription Factors | 2005 |
SET8 recognizes the sequence RHRK20VLRDN within the N terminus of histone H4 and mono-methylates lysine 20.
Topics: Alanine; Arginine; DNA Methylation; Glutamine; Glutathione Transferase; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Mass Spectrometry; Methionine; Methylation; Mutation; Peptides; Plasmids; Protein Structure, Tertiary; Recombinant Proteins; Substrate Specificity | 2005 |
Astrocyte- and hepatocyte-specific expression of genes from the distal serpin subcluster at 14q32.1 associates with tissue-specific chromatin structures.
Topics: Astrocytes; Blotting, Northern; Carrier Proteins; Cells, Cultured; Chromatin; Chromatin Immunoprecipitation; Chromosome Mapping; Chromosomes, Human, Pair 14; Chymotrypsin; Cytokines; Deoxyribonuclease I; Enhancer Elements, Genetic; Gene Expression Regulation; Hepatocytes; Histones; Humans; Locus Control Region; Lysine; Methylation; Promoter Regions, Genetic; Protein C Inhibitor; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Serine Proteinase Inhibitors; Serpins; Transcription, Genetic; Transfection | 2005 |
An archaeal SET domain protein exhibits distinct lysine methyltransferase activity towards DNA-associated protein MC1-alpha.
Topics: Amino Acid Sequence; Archaeal Proteins; Chromatin; Dimerization; DNA-Binding Proteins; Genes, Archaeal; Histone-Lysine N-Methyltransferase; Lysine; Methanosarcina; Methylation; Molecular Sequence Data; Substrate Specificity | 2005 |
Ubp10/Dot4p regulates the persistence of ubiquitinated histone H2B: distinct roles in telomeric silencing and general chromatin.
Topics: Chromatin; Endopeptidases; Gene Deletion; Gene Silencing; Histones; Lysine; Methylation; Nuclear Proteins; Saccharomyces cerevisiae Proteins; Telomere; Ubiquitin; Ubiquitin Thiolesterase | 2005 |
Histone methylation at gene promoters is associated with developmental regulation and region-specific expression of ionotropic and metabotropic glutamate receptors in human brain.
Topics: Aged; Analysis of Variance; Cerebral Cortex; Chromatin; Fetus; Gene Expression Regulation, Developmental; Gestational Age; Histone-Lysine N-Methyltransferase; Histones; Humans; Immunohistochemistry; Immunoprecipitation; Infant, Newborn; Lysine; Methylation; Nucleosomes; Postmortem Changes; Promoter Regions, Genetic; Receptors, Glutamate; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 2005 |
Arginine methylation of yeast mRNA-binding protein Npl3 directly affects its function, nuclear export, and intranuclear protein interactions.
Topics: Active Transport, Cell Nucleus; Amino Acid Sequence; Arginine; Humans; Lysine; Methylation; Molecular Sequence Data; Mutagenesis, Site-Directed; Nuclear Proteins; Peptides; Protein Interaction Mapping; RNA-Binding Proteins; Saccharomyces cerevisiae Proteins; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Spectroscopy, Fourier Transform Infrared; Transcription Factors | 2005 |
Increased lysine N-methylation of a 23-kDa protein during hepatic regeneration.
Topics: Animals; Cytochromes c; DNA Helicases; Hepatectomy; Histone-Lysine N-Methyltransferase; Histones; Liver; Liver Regeneration; Lysine; Methylation; Proteins; Rats; Rats, Sprague-Dawley | 2005 |
BUR kinase selectively regulates H3 K4 trimethylation and H2B ubiquitylation through recruitment of the PAF elongation complex.
Topics: Chromatin Immunoprecipitation; Cyclins; DNA-Binding Proteins; Gene Expression Regulation, Fungal; Histone-Lysine N-Methyltransferase; Histones; Immunoblotting; Lysine; Methylation; Microarray Analysis; Nuclear Proteins; Saccharomyces cerevisiae Proteins; Transcription Factors; Ubiquitin-Conjugating Enzymes; Yeasts | 2005 |
The Wnt-NLK signaling pathway inhibits A-Myb activity by inhibiting the association with coactivator CBP and methylating histone H3.
Topics: Animals; Carrier Proteins; Cell Line; Chlorocebus aethiops; CREB-Binding Protein; Histones; Humans; Lysine; Methylation; Mitogen-Activated Protein Kinases; Phosphorylation; Promoter Regions, Genetic; Protein Binding; Proto-Oncogene Mas; Proto-Oncogene Proteins; Signal Transduction; Trans-Activators; Transcriptional Activation; Wnt Proteins | 2005 |
Subunit contributions to histone methyltransferase activities of fly and worm polycomb group complexes.
Topics: Animals; Baculoviridae; Blotting, Western; Caenorhabditis elegans; Catalytic Domain; Chromatin; Chromosomal Proteins, Non-Histone; DNA Methylation; DNA Mutational Analysis; Dose-Response Relationship, Drug; Drosophila melanogaster; Drosophila Proteins; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Macromolecular Substances; Methylation; Models, Biological; Molecular Chaperones; Multiprotein Complexes; Mutagenesis, Site-Directed; Mutation; Mutation, Missense; Polycomb Repressive Complex 1; Polycomb Repressive Complex 2; Protein Binding; Protein Methyltransferases; Protein Structure, Tertiary; Recombinant Fusion Proteins; Recombinant Proteins; Repressor Proteins; Retinoblastoma-Binding Protein 4; Zinc Fingers | 2005 |
Histone H3 lysine 9 methylation and HP1gamma are associated with transcription elongation through mammalian chromatin.
Topics: Animals; Anion Exchange Protein 1, Erythrocyte; Cell Line; Cell Line, Tumor; Chromatin; Chromatin Immunoprecipitation; Chromobox Protein Homolog 5; Chromosomal Proteins, Non-Histone; Dichlororibofuranosylbenzimidazole; DNA-Binding Proteins; Erythroid Cells; Erythroid-Specific DNA-Binding Factors; GATA2 Transcription Factor; Globins; HeLa Cells; Histones; Humans; Interleukin-2; Kinetics; Liver; Lysine; Methylation; Mice; Phosphorylation; Protein Binding; Protein Isoforms; Proto-Oncogene Proteins c-kit; Proto-Oncogene Proteins c-myc; RNA Polymerase II; T-Lymphocytes; Transcription Factors; Transcription, Genetic | 2005 |
An essential role for CoREST in nucleosomal histone 3 lysine 4 demethylation.
Topics: Acetylation; Amino Acid Sequence; Cell Line; DNA-Binding Proteins; Histone Deacetylases; Histone Demethylases; Histones; Humans; Lysine; Methylation; Molecular Sequence Data; Multiprotein Complexes; Nerve Tissue Proteins; Nucleosomes; Oxidoreductases, N-Demethylating | 2005 |
Histone H3 K36 methylation is associated with transcription elongation in Schizosaccharomyces pombe.
Topics: Animals; Conserved Sequence; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Methyltransferases; Nucleosomes; Phylogeny; Protein Methyltransferases; RNA Polymerase II; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Schizosaccharomyces; Sequence Deletion; Transcription, Genetic | 2005 |
Methylation of histone H3 lysine 36 is required for normal development in Neurospora crassa.
Topics: Chromatin; Chromatin Immunoprecipitation; Genotype; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Methyltransferases; Neurospora crassa; Nucleosomes; Phenotype; Saccharomyces cerevisiae Proteins | 2005 |
A novel SET domain methyltransferase modifies ribosomal protein Rpl23ab in yeast.
Topics: Amino Acid Sequence; Catalysis; Electrophoresis, Polyacrylamide Gel; Endopeptidase K; Gene Deletion; Gene Expression Regulation, Fungal; Genotype; Histone-Lysine N-Methyltransferase; Lysine; Mass Spectrometry; Methylation; Molecular Sequence Data; Mutation; Peptides; Protein Structure, Tertiary; Ribonucleases; Ribosomal Proteins; Ribosomes; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Spectrometry, Mass, Electrospray Ionization; Subcellular Fractions; Sucrose; Temperature; Transcription, Genetic; Trypsin | 2005 |
Monomethyl histone H3 lysine 4 as an epigenetic mark for silenced euchromatin in Chlamydomonas.
Topics: Algal Proteins; Amino Acid Sequence; Animals; Chlamydomonas reinhardtii; Epigenesis, Genetic; Euchromatin; Gene Expression Regulation, Plant; Gene Silencing; Histones; Lysine; Macromolecular Substances; Methylation; Molecular Sequence Data; Phylogeny; Protein Subunits; Protozoan Proteins; RNA Interference; Sequence Alignment; Two-Hybrid System Techniques | 2005 |
Lysine residues in N-terminal and C-terminal regions of human histone H2A are targets for biotinylation by biotinidase.
Topics: Acetylation; Amino Acid Sequence; Biotinidase; Biotinylation; Carbon-Nitrogen Ligases; Histones; Humans; Lysine; Methylation; Molecular Sequence Data; Peptide Fragments | 2006 |
Mass spectrometric analysis of histone posttranslational modifications.
Topics: Acetylation; Amino Acid Sequence; Animals; Chromatography, High Pressure Liquid; Fourier Analysis; Histones; Humans; Ions; Lysine; Mass Spectrometry; Methylation; Molecular Weight; Peptide Fragments; Phosphorylation; Protein Processing, Post-Translational; Spectrometry, Mass, Electrospray Ionization; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Trypsin | 2005 |
Trilogies of histone lysine methylation as epigenetic landmarks of the eukaryotic genome.
Topics: Animals; Chromatin; Drosophila melanogaster; Epigenesis, Genetic; Eukaryotic Cells; Evolution, Molecular; Gene Silencing; Genome; Heterochromatin; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Protein Methyltransferases; Saccharomyces cerevisiae; Schizosaccharomyces | 2004 |
The Ezh2 methyltransferase complex: actin up in the cytosol.
Topics: Actins; Animals; Cytosol; Drosophila melanogaster; Drosophila Proteins; Lysine; Methylation; Multiprotein Complexes; Nuclear Proteins; Polycomb Repressive Complex 2; Proto-Oncogene Proteins c-vav; Repressor Proteins | 2005 |
HP1 binds specifically to Lys26-methylated histone H1.4, whereas simultaneous Ser27 phosphorylation blocks HP1 binding.
Topics: Animals; Cell Nucleus; Chromobox Protein Homolog 5; Chromosomal Proteins, Non-Histone; HeLa Cells; Histones; Humans; Lysine; Methylation; Mice; Phosphorylation; Phosphoserine; Protein Binding; Substrate Specificity | 2005 |
Lack of telomerase gene expression in alternative lengthening of telomere cells is associated with chromatin remodeling of the hTR and hTERT gene promoters.
Topics: Acetylation; Cell Line, Tumor; Chromatin; DNA Methylation; DNA-Binding Proteins; Enzyme Activation; Gene Expression; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Histones; Humans; Lysine; Methylation; Promoter Regions, Genetic; Telomerase; Telomere; Transcription, Genetic | 2005 |
Pdx-1 links histone H3-Lys-4 methylation to RNA polymerase II elongation during activation of insulin transcription.
Topics: Adenoviridae; Animals; Cell Line; Chromatin; Chromatin Immunoprecipitation; DNA Methylation; Genetic Vectors; Glutathione Transferase; HeLa Cells; Histones; Homeodomain Proteins; Humans; Immunoblotting; Immunohistochemistry; Immunoprecipitation; Insulin; Insulin-Secreting Cells; Islets of Langerhans; Lysine; Methylation; Mice; Models, Genetic; NIH 3T3 Cells; Phosphorylation; Promoter Regions, Genetic; Protein Isoforms; Protein Structure, Tertiary; Reverse Transcriptase Polymerase Chain Reaction; RNA Polymerase II; RNA, Small Interfering; Serine; Trans-Activators; Transcription, Genetic; Transcriptional Activation; Transfection | 2005 |
Epigenetic basis for the transcriptional hyporesponsiveness of the human inducible nitric oxide synthase gene in vascular endothelial cells.
Topics: Cell Line, Tumor; Cells, Cultured; Chromatin; CpG Islands; DNA Methylation; Endothelial Cells; Endothelium, Vascular; Epigenesis, Genetic; Gene Silencing; Histones; Humans; Lysine; Methyl-CpG-Binding Protein 2; Methylation; Muscle, Smooth, Vascular; Promoter Regions, Genetic; Species Specificity; Transcription, Genetic | 2005 |
Methylation patterns of histone H3 Lys 4, Lys 9 and Lys 27 in transcriptionally active and inactive Arabidopsis genes and in atx1 mutants.
Topics: Arabidopsis; Arabidopsis Proteins; Chromatin; Gene Expression Regulation, Plant; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Mutation; Nucleosomes; Plant Leaves; Promoter Regions, Genetic; Transcription Factors; Transcription, Genetic | 2005 |
Histone H4-lysine 20 monomethylation is increased in promoter and coding regions of active genes and correlates with hyperacetylation.
Topics: Acetylation; Animals; Blotting, Western; Butyrates; Cell Differentiation; Cell Line; Cell Line, Tumor; Chromatin; Chromatin Immunoprecipitation; Chromatography, Liquid; Cross-Linking Reagents; Down-Regulation; Exons; Formaldehyde; Globins; Heterochromatin; Histones; Immunoprecipitation; Isobutyrates; Lysine; Methylation; Mice; Microscopy, Fluorescence; Polymerase Chain Reaction; Protein Binding; Proto-Oncogene Proteins c-myc; Reverse Transcriptase Polymerase Chain Reaction; Time Factors; Transcription, Genetic | 2005 |
Role of Dot1-dependent histone H3 methylation in G1 and S phase DNA damage checkpoint functions of Rad9.
Topics: Blotting, Western; Cell Cycle; Cell Cycle Proteins; Checkpoint Kinase 2; Chromatin Immunoprecipitation; DNA; DNA Damage; Dose-Response Relationship, Radiation; Epitopes; G1 Phase; Gene Deletion; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Models, Biological; Mutagenesis, Site-Directed; Mutation; Nuclear Proteins; Phosphorylation; Protein Methyltransferases; Protein Serine-Threonine Kinases; Radiation, Ionizing; S Phase; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Signal Transduction; Time Factors | 2005 |
Histone H3 lysine 4 mono-methylation does not require ubiquitination of histone H2B.
Topics: Histones; Lysine; Methylation; Saccharomyces cerevisiae; Ubiquitin | 2005 |
Fourier transform ion cyclotron resonance mass spectrometry for the analysis of small ubiquitin-like modifier (SUMO) modification: identification of lysines in RanBP2 and SUMO targeted for modification during the E3 autoSUMOylation reaction.
Topics: Amino Acid Sequence; Cyclotrons; Fourier Analysis; Ions; Lysine; Mass Spectrometry; Methylation; Molecular Chaperones; Molecular Sequence Data; Molecular Weight; Nuclear Pore Complex Proteins; Protein Binding; Recombinant Proteins; Sequence Alignment; Small Ubiquitin-Related Modifier Proteins; Ubiquitin; Ubiquitin-Protein Ligases | 2005 |
Role of histone modifications in marking and activating genes through mitosis.
Topics: Acetylation; Cell Cycle; Cell Nucleus; Cell Nucleus Division; Chromatin; Chromatin Immunoprecipitation; Cyclin B; Cyclin B1; Fluorescent Antibody Technique, Indirect; Gene Expression Regulation; HeLa Cells; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; Immunoblotting; Interphase; Lysine; Methylation; Mitosis; Nucleosomes; Polymerase Chain Reaction; Promoter Regions, Genetic; Protein Methyltransferases; Protein Processing, Post-Translational; RNA Polymerase II; Temperature; Transcription, Genetic; Transcriptional Activation | 2005 |
Mapping post-translational modifications of the histone variant MacroH2A1 using tandem mass spectrometry.
Topics: Histones; Immunoprecipitation; Lysine; Methylation; Phosphorylation; Protein Processing, Post-Translational; Spectrometry, Mass, Electrospray Ionization; Ubiquitin | 2006 |
Histone lysine methylation patterns in human cell types are arranged in distinct three-dimensional nuclear zones.
Topics: Algorithms; Cell Cycle; Cell Nucleus; Cells, Cultured; Centromere; DNA; Female; Fibroblasts; Histones; Humans; Image Processing, Computer-Assisted; Immunohistochemistry; Lysine; Methylation; Microscopy, Confocal; RNA | 2006 |
Human histone demethylase LSD1 reads the histone code.
Topics: Amino Acid Sequence; Catalysis; Chromatin; Chromatography, Gel; Dose-Response Relationship, Drug; Enzyme Inhibitors; Epigenesis, Genetic; Escherichia coli; Flavins; Histone Demethylases; Histones; Humans; Hydrogen-Ion Concentration; Ions; Kinetics; Lysine; Methylation; Models, Biological; Models, Chemical; Models, Genetic; Molecular Sequence Data; Monoamine Oxidase; Oxidoreductases, N-Demethylating; Peptides; Protein Structure, Tertiary; Recombinant Proteins; Serine; Static Electricity; Substrate Specificity; Time Factors | 2005 |
Akt-mediated phosphorylation of EZH2 suppresses methylation of lysine 27 in histone H3.
Topics: 3T3 Cells; Animals; Cell Line; Cell Transformation, Neoplastic; Chlorocebus aethiops; Chromones; COS Cells; DNA-Binding Proteins; Enhancer of Zeste Homolog 2 Protein; Enzyme Inhibitors; Gene Expression Regulation; HeLa Cells; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Homeodomain Proteins; Humans; Lysine; Methylation; Mice; Molecular Sequence Data; Morpholines; Phosphorylation; Polycomb Repressive Complex 2; Protein Binding; Protein Methyltransferases; Protein Serine-Threonine Kinases; Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Serine; Transcription Factors | 2005 |
Dimethylation of histone H3 at lysine 36 demarcates regulatory and nonregulatory chromatin genome-wide.
Topics: Chromatin; Chromatin Immunoprecipitation; DNA Primers; Genome, Fungal; Histones; Lysine; Methylation; Methyltransferases; Nucleosomes; Open Reading Frames; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins | 2005 |
Proteomic analysis of organ-specific post-translational lysine-acetylation and -methylation in mice by use of anti-acetyllysine and -methyllysine mouse monoclonal antibodies.
Topics: Acetylation; Actins; Animals; Antibodies, Monoclonal; Brain Chemistry; Creatine Kinase, MM Form; Cross Reactions; Female; Histones; Horseradish Peroxidase; Hybridomas; Lysine; Methylation; Mice; Muscle Proteins; Muscle, Skeletal; Nerve Tissue Proteins; Organ Specificity; Protein Processing, Post-Translational; Proteomics; Tubulin | 2005 |
Dynamic acetylation of all lysine 4-methylated histone H3 in the mouse nucleus: analysis at c-fos and c-jun.
Topics: Acetylation; Animals; Cell Nucleus; Cells, Cultured; Enzyme Activation; Histones; Hydroxamic Acids; Lysine; Methylation; Mice; Mitogen-Activated Protein Kinases; Phosphorylation; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Tetradecanoylphorbol Acetate | 2005 |
Human but not yeast CHD1 binds directly and selectively to histone H3 methylated at lysine 4 via its tandem chromodomains.
Topics: Amino Acid Sequence; DNA Helicases; DNA-Binding Proteins; Histones; Humans; Lysine; Methylation; Molecular Sequence Data; Protein Binding; Saccharomyces cerevisiae Proteins; Sequence Homology, Amino Acid; Species Specificity | 2005 |
Truncated HP1 lacking a functional chromodomain induces heterochromatinization upon in vivo targeting.
Topics: Animals; CHO Cells; Chromatin; Chromobox Protein Homolog 5; Chromosomal Proteins, Non-Histone; Cricetinae; Fluorescent Antibody Technique; Heterochromatin; Histones; Humans; Image Interpretation, Computer-Assisted; Lysine; Methylation; Microscopy, Confocal; Plasmids | 2006 |
Cotranscriptional set2 methylation of histone H3 lysine 36 recruits a repressive Rpd3 complex.
Topics: Acetylation; Acetyltransferases; Amino Acid Sequence; Cluster Analysis; Cyclin-Dependent Kinases; Down-Regulation; Epistasis, Genetic; Gene Deletion; Gene Expression Regulation, Fungal; Histone Deacetylases; Histones; Lysine; Methylation; Methyltransferases; Molecular Sequence Data; Mutation; Oligonucleotide Array Sequence Analysis; Protein Binding; Repressor Proteins; RNA Polymerase II; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sequence Homology, Amino Acid; Silent Information Regulator Proteins, Saccharomyces cerevisiae; Sirtuin 2; Sirtuins; Suppression, Genetic; Transcription Factors | 2005 |
Structure and carboxyl-terminal domain (CTD) binding of the Set2 SRI domain that couples histone H3 Lys36 methylation to transcription.
Topics: Amino Acid Sequence; Chromatin; Conserved Sequence; Gene Expression Regulation, Fungal; Histones; Lysine; Methylation; Methyltransferases; Molecular Sequence Data; Protein Binding; Protein Structure, Tertiary; RNA Polymerase II; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Transcription, Genetic | 2006 |
H3 lysine 9 methylation is maintained on a transcribed inverted repeat by combined action of SUVH6 and SUVH4 methyltransferases.
Topics: Arabidopsis; Arabidopsis Proteins; DNA Methylation; DNA, Plant; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Methyltransferases; Mutation; Plants, Genetically Modified; Repetitive Sequences, Nucleic Acid; Transcription Initiation Site; Transcription, Genetic | 2005 |
Mass spectrometry assisted assignment of NMR resonances in reductively 13C-methylated proteins.
Topics: Carbon Isotopes; Dimethylamines; Egg Proteins; Isotope Labeling; Lysine; Methylation; Muramidase; Nuclear Magnetic Resonance, Biomolecular; Peptide Fragments; Proteins; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2005 |
Drosophila Paf1 modulates chromatin structure at actively transcribed genes.
Topics: Animals; Chromatin; Chromatin Immunoprecipitation; DNA Polymerase II; DNA-Binding Proteins; Drosophila melanogaster; Drosophila Proteins; High Mobility Group Proteins; Histones; HSP70 Heat-Shock Proteins; Lysine; Methylation; Peptide Elongation Factors; Phosphorylation; Promoter Regions, Genetic; RNA Interference; RNA, Messenger; Transcription, Genetic; Transcriptional Activation; Transcriptional Elongation Factors | 2006 |
Leukemogenic MLL fusion proteins bind across a broad region of the Hox a9 locus, promoting transcription and multiple histone modifications.
Topics: Dimerization; Gene Expression Regulation; Histone-Lysine N-Methyltransferase; Histones; Homeodomain Proteins; Humans; Lysine; Methylation; Myeloid Ecotropic Viral Integration Site 1 Protein; Myeloid-Lymphoid Leukemia Protein; Neoplasm Proteins; Oncogene Proteins, Fusion; Promoter Regions, Genetic; Protein Binding; Transcription, Genetic | 2005 |
Double chromodomains cooperate to recognize the methylated histone H3 tail.
Topics: Amino Acid Sequence; Animals; Chromatin; Chromobox Protein Homolog 5; Chromosomal Proteins, Non-Histone; Crystallography, X-Ray; DNA Helicases; DNA-Binding Proteins; Drosophila Proteins; Histones; Humans; Lysine; Methylation; Models, Molecular; Molecular Sequence Data; Polycomb Repressive Complex 1; Protein Structure, Tertiary; Structure-Activity Relationship | 2005 |
Dynamic changes in histone H3 lysine 9 methylations: identification of a mitosis-specific function for dynamic methylation in chromosome congression and segregation.
Topics: Adenosine; Animals; Antineoplastic Agents; Cell Line; Cell Line, Transformed; Chromosome Segregation; Chromosomes, Human; Enzyme Inhibitors; Fibroblasts; Flow Cytometry; Fluorescent Antibody Technique, Direct; Fluorescent Dyes; Green Fluorescent Proteins; HeLa Cells; Histones; Humans; Immunoblotting; Indoles; Lysine; Methylation; Mitosis; Muntjacs; Nocodazole; Protein Isoforms; Skin | 2006 |
Methylation changes of lysine 9 of histone H3 during preimplantation mouse development.
Topics: Animals; Blastocyst; Cell Nucleus; Female; Gene Expression Regulation, Developmental; Histones; Lysine; Male; Methylation; Mice; Mice, Inbred C57BL; Oocytes; Swine; Zygote | 2005 |
The tumor suppressor menin regulates hematopoiesis and myeloid transformation by influencing Hox gene expression.
Topics: Animals; Blotting, Western; Cell Line, Transformed; Cell Proliferation; Chromatin Immunoprecipitation; DNA; DNA Methylation; DNA-Binding Proteins; Exons; Flow Cytometry; Gene Expression Regulation; Genotype; Hematopoiesis; Histones; Homeodomain Proteins; Homozygote; Leukemia; Lysine; Methylation; Mice; Mice, Knockout; Mice, Transgenic; Models, Genetic; Models, Statistical; Myeloid Cells; Proto-Oncogene Proteins; Retroviridae; Reverse Transcriptase Polymerase Chain Reaction; Stem Cells; Time Factors; Transgenes | 2006 |
Tudor, MBT and chromo domains gauge the degree of lysine methylation.
Topics: Histones; Lysine; Methylation; Protein Array Analysis; Protein Binding; Protein Structure, Tertiary | 2006 |
Substrate preferences of the EZH2 histone methyltransferase complex.
Topics: Baculoviridae; Chromatin; DNA-Binding Proteins; Electrophoresis, Agar Gel; Enhancer of Zeste Homolog 2 Protein; Genes, Homeobox; Glutathione Transferase; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methionine; Methylation; Nucleosomes; Polycomb Repressive Complex 2; Protein Isoforms; Protein Methyltransferases; Recombinant Fusion Proteins; Substrate Specificity; Sulfur Radioisotopes; Transcription Factors; X Chromosome Inactivation | 2006 |
Accelerated on-column lysine derivatization and cysteine methylation by imidazole reaction in a deuterated environment for enhanced product ion analysis.
Topics: Amino Acid Sequence; Cysteine; Deuterium; Erythropoietin; Humans; Imidazoles; Interferon alpha-2; Interferon-alpha; Lysine; Metalloendopeptidases; Methylation; Molecular Sequence Data; Molecular Structure; Recombinant Proteins; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Time Factors; Trypsin | 2006 |
Synthesis of trimethyl (2S,3R)- and (2R,3R)-[2-2H1]-homocitrates and dimethyl (2S,3R)- and (2R,3R)-[2-2H1]-homocitrate lactones-an assay for the stereochemical outcome of the reaction catalysed both by homocitrate synthase and by the Nif-V protein.
Topics: Bacterial Proteins; Catalysis; Lactones; Lysine; Magnetic Resonance Spectroscopy; Methylation; Molecular Structure; Oxo-Acid-Lyases; Stereoisomerism; Tricarboxylic Acids | 2006 |
Developmental timing in Dictyostelium is regulated by the Set1 histone methyltransferase.
Topics: Amino Acid Sequence; Animals; Biomarkers; Blotting, Western; Cell Differentiation; Chromatin Immunoprecipitation; Cluster Analysis; Dictyostelium; Gene Expression Profiling; Gene Expression Regulation, Developmental; Genes, Protozoan; Genome, Protozoan; Genomics; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Luminescent Measurements; Lysine; Methylation; Molecular Sequence Data; Mutation; Oligonucleotide Array Sequence Analysis; Phylogeny; Protein Methyltransferases; Protein Structure, Tertiary; Protozoan Proteins; Sequence Homology, Amino Acid; Time Factors; Transcription, Genetic | 2006 |
Chromatin assembly factor 1 interacts with histone H3 methylated at lysine 79 in the processes of epigenetic silencing and DNA repair.
Topics: Amino Acid Sequence; Cell Extracts; Chromatin Assembly Factor-1; Chromosomal Proteins, Non-Histone; DNA Repair; DNA-Binding Proteins; Epigenesis, Genetic; Gene Silencing; Histones; Lysine; Mass Spectrometry; Methylation; Molecular Sequence Data; Nucleosomes; S Phase; Saccharomyces cerevisiae; Silent Information Regulator Proteins, Saccharomyces cerevisiae | 2006 |
A trans-tail histone code defined by monomethylated H4 Lys-20 and H3 Lys-9 demarcates distinct regions of silent chromatin.
Topics: Amino Acid Sequence; Animals; Chromatin; Fibroblasts; HeLa Cells; Histones; Humans; Lysine; Methylation; Mice; Molecular Sequence Data; Protein Processing, Post-Translational | 2006 |
Catalytic properties and kinetic mechanism of human recombinant Lys-9 histone H3 methyltransferase SUV39H1: participation of the chromodomain in enzymatic catalysis.
Topics: Amino Acid Sequence; Animals; Baculoviridae; Catalytic Domain; Cell Line; Chromatin; Coenzymes; Dose-Response Relationship, Drug; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; Kinetics; Lysine; Methylation; Methyltransferases; Models, Biological; Molecular Sequence Data; Peptides; Protein Methyltransferases; Recombinant Proteins; Repressor Proteins; S-Adenosylhomocysteine; S-Adenosylmethionine; Spodoptera; Substrate Specificity; Time Factors | 2006 |
Nonadditive regulation of FRI and FLC loci mediates flowering-time variation in Arabidopsis allopolyploids.
Topics: Acetylation; Arabidopsis; Arabidopsis Proteins; Base Sequence; DNA, Plant; Epigenesis, Genetic; Evolution, Molecular; Flowers; Gene Duplication; Gene Expression Regulation, Plant; Gene Silencing; Genes, Plant; Genetic Complementation Test; Genetic Variation; Histones; Lysine; MADS Domain Proteins; Methylation; Molecular Sequence Data; Phylogeny; Polyploidy; Species Specificity; Transcriptional Activation; Up-Regulation | 2006 |
Histone lysine trimethylation exhibits a distinct perinuclear distribution in Plzf-expressing spermatogonia.
Topics: Animals; Base Sequence; Cell Nucleus; DNA; DNA-Binding Proteins; Histones; Kruppel-Like Transcription Factors; Lysine; Male; Methylation; Mice; Mice, Inbred C57BL; Mice, Mutant Strains; Microscopy, Fluorescence; Promyelocytic Leukemia Zinc Finger Protein; Proto-Oncogene Proteins c-kit; Spermatogonia; Testis; Transcription Factors | 2006 |
Methylation of histone H3 mediates the association of the NuA3 histone acetyltransferase with chromatin.
Topics: Blotting, Western; Chromatin; Histone Acetyltransferases; Histones; Lysine; Methylation; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins | 2006 |
The BUR1 cyclin-dependent protein kinase is required for the normal pattern of histone methylation by SET2.
Topics: Alleles; Blotting, Western; Chromatin Immunoprecipitation; Cyclin-Dependent Kinases; DNA-Binding Proteins; Fungal Proteins; Gene Deletion; Gene Expression Regulation, Fungal; Genes, Fungal; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Open Reading Frames; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Transcription Factors | 2006 |
[Histone demethylation isn't what it used to be].
Topics: Arginine; Citrulline; Dioxygenases; F-Box Proteins; Gene Expression Regulation; Histone Demethylases; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; Hydrolases; Jumonji Domain-Containing Histone Demethylases; Lysine; Methylation; Oxidoreductases, N-Demethylating; Protein Methyltransferases; Protein Processing, Post-Translational; Protein-Arginine Deiminase Type 4; Protein-Arginine Deiminases | 2006 |
Structural basis for the specific recognition of methylated histone H3 lysine 4 by the WD-40 protein WDR5.
Topics: Amino Acid Sequence; Crystallography, X-Ray; Heterotrimeric GTP-Binding Proteins; Histone-Lysine N-Methyltransferase; Histones; Humans; Hydrogen Bonding; Intracellular Signaling Peptides and Proteins; Lysine; Methylation; Molecular Sequence Data; Mutation; Peptide Fragments; Protein Structure, Tertiary; Sequence Homology, Amino Acid | 2006 |
Recognition of histone H3 lysine-4 methylation by the double tudor domain of JMJD2A.
Topics: Amino Acid Motifs; Amino Acid Sequence; Binding Sites; Crystallography, X-Ray; DNA-Binding Proteins; Histones; Humans; Hydrogen Bonding; Jumonji Domain-Containing Histone Demethylases; Lysine; Methylation; Models, Molecular; Molecular Sequence Data; Mutation; Oxidoreductases, N-Demethylating; Protein Binding; Protein Conformation; Protein Folding; Protein Structure, Tertiary; Static Electricity; Transcription Factors | 2006 |
Structural insights of the specificity and catalysis of a viral histone H3 lysine 27 methyltransferase.
Topics: Amino Acid Sequence; Animals; DNA Mutational Analysis; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Nuclear Magnetic Resonance, Biomolecular; Paramecium; Peptides; Phycodnaviridae; Protein Methyltransferases; Protein Structure, Quaternary; S-Adenosylhomocysteine; Sequence Alignment; Viral Proteins | 2006 |
Histone modifications silence the GATA transcription factor genes in ovarian cancer.
Topics: Acetylation; Adaptor Proteins, Signal Transducing; Apoptosis Regulatory Proteins; Carcinoma; Cell Line, Tumor; Female; GATA Transcription Factors; GATA4 Transcription Factor; GATA6 Transcription Factor; Gene Silencing; Genes, Tumor Suppressor; Heterochromatin; Histones; Humans; Lysine; Methylation; Ovarian Neoplasms; Tumor Suppressor Proteins | 2006 |
Ubp8p, a histone deubiquitinase whose association with SAGA is mediated by Sgf11p, differentially regulates lysine 4 methylation of histone H3 in vivo.
Topics: Alcohol Dehydrogenase; Carrier Proteins; Chromatin Immunoprecipitation; Endopeptidases; Histones; Lysine; Metallothionein; Methylation; Mutation; Promoter Regions, Genetic; Proton-Phosphate Symporters; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Trans-Activators; Transcription Factors; Ubiquitin | 2006 |
The retinoblastoma protein regulates pericentric heterochromatin.
Topics: Aneuploidy; Animals; Binding Sites; Cell Cycle; Cells, Cultured; Centromere; Heterochromatin; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Mice; Mice, Mutant Strains; Mitosis; Mutation; Retinoblastoma Protein | 2006 |
Histone H3 lysine 4 dimethylation signals the transcriptional competence of the adiponectin promoter in preadipocytes.
Topics: 3T3-L1 Cells; Adipocytes; Adiponectin; Animals; Chromatin; Histones; Lysine; Male; Methylation; Mice; Mice, Inbred C57BL; Promoter Regions, Genetic; Protein Processing, Post-Translational; Transcription, Genetic | 2006 |
A Polycomb group protein complex with sequence-specific DNA-binding and selective methyl-lysine-binding activities.
Topics: Amino Acid Sequence; Animals; Animals, Genetically Modified; Chromatin; DNA-Binding Proteins; Drosophila melanogaster; Drosophila Proteins; Embryo, Nonmammalian; Gene Silencing; Histones; Homeodomain Proteins; Lysine; Methylation; Molecular Sequence Data; Polycomb-Group Proteins; Protein Binding; Transcription Factors | 2006 |
Partitioning of the maize epigenome by the number of methyl groups on histone H3 lysines 9 and 27.
Topics: Animals; Cells, Cultured; Centromere; Euchromatin; Evolution, Molecular; Fluorescent Antibody Technique; Genome, Plant; Heterochromatin; Histones; Lysine; Methylation; Mice; Models, Biological; Neocortex; Zea mays | 2006 |
Histone lysine demethylases and their impact on epigenetics.
Topics: Animals; Chromatin; Epigenesis, Genetic; Histones; Lysine; Methylation; Oxidoreductases, N-Demethylating | 2006 |
Histone H2A phosphorylation and H3 methylation are required for a novel Rad9 DSB repair function following checkpoint activation.
Topics: Cell Cycle Proteins; Checkpoint Kinase 2; Chromatin; DNA; DNA Damage; DNA Methylation; DNA Repair; Green Fluorescent Proteins; Histone-Lysine N-Methyltransferase; Histones; Intracellular Signaling Peptides and Proteins; Lysine; Methylation; Nuclear Proteins; Phosphorylation; Protein Serine-Threonine Kinases; Recombination, Genetic; Saccharomyces cerevisiae Proteins | 2006 |
Functional analysis of H2B-Lys-123 ubiquitination in regulation of H3-Lys-4 methylation and recruitment of RNA polymerase II at the coding sequences of several active genes in vivo.
Topics: Chromatin Immunoprecipitation; DNA Primers; Histones; Lysine; Methylation; Models, Genetic; Open Reading Frames; Plasmids; RNA Polymerase II; Saccharomyces cerevisiae; Ubiquitin | 2006 |
Aurora-B/AIM-1 regulates the dynamic behavior of HP1alpha at the G2-M transition.
Topics: Animals; Aurora Kinase B; Aurora Kinases; Cell Division; Cells, Cultured; Chromobox Protein Homolog 5; Chromosomal Proteins, Non-Histone; Chromosomes; Cricetinae; G2 Phase; Heterochromatin; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Mitosis; Phosphorylation; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Protein Structure, Tertiary; Rats; Serine | 2006 |
Self-aggregation of fibrillar collagens I and II involves lysine side chains.
Topics: Acetylation; Collagen Type I; Collagen Type II; Kinetics; Lysine; Macromolecular Substances; Methylation; Microscopy, Electron, Transmission; Nephelometry and Turbidimetry | 2006 |
Determination of the orientation of adsorbed cytochrome C on carboxyalkanethiol self-assembled monolayers by in situ differential modification.
Topics: Amino Acid Sequence; Animals; Binding Sites; Biochemistry; Chromatography, Liquid; Cytochromes c; Electrodes; Gold; Horses; Lysine; Mass Spectrometry; Methylation; Models, Molecular; Molecular Sequence Data; Protein Conformation; Schiff Bases; Trypsin | 2006 |
ING2 PHD domain links histone H3 lysine 4 methylation to active gene repression.
Topics: Amino Acid Motifs; Chromatin; Gene Silencing; Histone Deacetylases; Histones; Homeodomain Proteins; Lysine; Methylation; Protein Binding; Protein Structure, Tertiary; Substrate Specificity; Tumor Suppressor Proteins | 2006 |
A PHD finger of NURF couples histone H3 lysine 4 trimethylation with chromatin remodelling.
Topics: Adenosine Triphosphatases; Amino Acid Motifs; Animals; Antigens, Nuclear; Chromatin Assembly and Disassembly; Chromosomal Proteins, Non-Histone; Epigenesis, Genetic; Gene Expression Regulation; Histones; Humans; Lysine; Methylation; Nerve Tissue Proteins; Transcription Factors; Xenopus | 2006 |
Molecular mechanism of histone H3K4me3 recognition by plant homeodomain of ING2.
Topics: Amino Acid Motifs; Animals; Binding Sites; Conserved Sequence; Crystallography, X-Ray; Histones; Homeodomain Proteins; Hydrogen Bonding; Lysine; Methylation; Mice; Models, Molecular; Mutation; Protein Binding; Protein Structure, Tertiary; Substrate Specificity; Tumor Suppressor Proteins | 2006 |
Molecular basis for site-specific read-out of histone H3K4me3 by the BPTF PHD finger of NURF.
Topics: Amino Acid Motifs; Antigens, Nuclear; Binding Sites; Calorimetry; Chromatin; Chromosomal Proteins, Non-Histone; Crystallography, X-Ray; Histones; Humans; Lysine; Methylation; Models, Molecular; Nerve Tissue Proteins; Nuclear Magnetic Resonance, Biomolecular; Protein Binding; Protein Conformation; Substrate Specificity; Surface Plasmon Resonance; Transcription Factors | 2006 |
Trimethylation of histone H3 lysine 4 by Set1 in the lytic infection of human herpes simplex virus 1.
Topics: Gene Expression Regulation, Viral; HeLa Cells; Herpes Simplex; Herpesvirus 1, Human; Histones; Humans; Lysine; Methylation; Methyltransferases; Transcription, Genetic; Virus Replication | 2006 |
The transcriptional repressor JHDM3A demethylates trimethyl histone H3 lysine 9 and lysine 36.
Topics: Animals; Chromobox Protein Homolog 5; Chromosomal Proteins, Non-Histone; DNA-Binding Proteins; Heterochromatin; Histones; Humans; Jumonji Domain-Containing Histone Demethylases; Lysine; Methylation; Mice; Oxidoreductases, N-Demethylating; Protein Structure, Tertiary; Repressor Proteins; Transcription Factors; Transcription, Genetic | 2006 |
The putative oncogene GASC1 demethylates tri- and dimethylated lysine 9 on histone H3.
Topics: Cell Proliferation; HeLa Cells; Histones; Humans; Hydroxylation; Jumonji Domain-Containing Histone Demethylases; Lysine; Methylation; Neoplasm Proteins; Oncogene Proteins; Oncogenes; Protein Binding; Substrate Specificity; Transcription Factors | 2006 |
Jmjd2b antagonizes H3K9 trimethylation at pericentric heterochromatin in mammalian cells.
Topics: Animals; Cells, Cultured; Chromosomes, Mammalian; Heterochromatin; Histones; Jumonji Domain-Containing Histone Demethylases; Lysine; Methylation; Methyltransferases; Mice; Mixed Function Oxygenases; Neoplasm Proteins; Repressor Proteins | 2006 |
Dynamic and reversible changes in histone H3-Lys4 methylation and H3 acetylation occurring at submergence-inducible genes in rice.
Topics: Acetylation; Chromatin; DNA, Plant; Gene Expression Regulation, Plant; Genes, Plant; Histones; Hydroxamic Acids; Lysine; Methylation; Oryza; Plant Proteins; Protein Synthesis Inhibitors; RNA Polymerase II | 2006 |
Structural characterization of Set1 RNA recognition motifs and their role in histone H3 lysine 4 methylation.
Topics: Amino Acid Sequence; Conserved Sequence; DNA-Binding Proteins; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Models, Molecular; Molecular Sequence Data; Protein Binding; Protein Structure, Quaternary; Protein Subunits; RNA, Fungal; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sequence Alignment; Structure-Activity Relationship; Surface Properties; Transcription Factors | 2006 |
Histone H3 lysine 4 demethylation is a target of nonselective antidepressive medications.
Topics: Amidohydrolases; Antidepressive Agents; Cell Line; Enzyme Inhibitors; Histones; Humans; Lysine; Methylation; Molecular Structure; Monoamine Oxidase; Monoamine Oxidase Inhibitors; Nucleosomes; Tranylcypromine | 2006 |
Sir2 represses endogenous polymerase II transcription units in the ribosomal DNA nontranscribed spacer.
Topics: Base Sequence; DNA, Ribosomal Spacer; Gene Expression Regulation, Fungal; Genes, Mating Type, Fungal; Histone Deacetylases; Histones; Lysine; Methylation; Molecular Sequence Data; Nucleosomes; Promoter Regions, Genetic; Protein Transport; Repressor Proteins; Retroelements; RNA Polymerase II; RNA, Messenger; Saccharomyces cerevisiae; Silent Information Regulator Proteins, Saccharomyces cerevisiae; Sirtuin 2; Sirtuins; Transcription, Genetic | 2006 |
Fragmentations of protonated arginine, lysine and their methylated derivatives: concomitant losses of carbon monoxide or carbon dioxide and an amine.
Topics: Amines; Arginine; Carbon Dioxide; Carbon Monoxide; Computer Simulation; Lysine; Mass Spectrometry; Methylation; Models, Chemical; Models, Molecular; Molecular Conformation; Protons | 2006 |
Gene regulation: a finger on the mark.
Topics: Amino Acid Motifs; Animals; Antigens, Nuclear; Chromatin; Gene Expression Regulation; Histones; Homeodomain Proteins; Humans; Lysine; Methylation; Nerve Tissue Proteins; Transcription Factors; Tumor Suppressor Proteins | 2006 |
Uncoupling global and fine-tuning replication timing determinants for mouse pericentric heterochromatin.
Topics: Animals; Cells, Cultured; Centrosome; Chromobox Protein Homolog 5; Chromosomal Proteins, Non-Histone; DNA Replication Timing; DNA, Satellite; Fibroblasts; G1 Phase; Heterochromatin; Histones; Lysine; Methylation; Methyltransferases; Mice; Protein Binding; Repressor Proteins; Xenopus | 2006 |
PHinDing a new histone "effector" domain.
Topics: Animals; DNA; Epigenesis, Genetic; Histones; Lysine; Methylation; Protein Structure, Tertiary | 2006 |
MeMo: a web tool for prediction of protein methylation modifications.
Topics: Arginine; Artificial Intelligence; Internet; Lysine; Methylation; Protein Processing, Post-Translational; Proteins; Software; User-Computer Interface | 2006 |
The epigenetic magic of histone lysine methylation.
Topics: Animals; Autobiographies as Topic; Epigenesis, Genetic; Forecasting; Gene Silencing; Heterochromatin; Histones; Humans; Lysine; Methylation; Methyltransferases; Models, Biological | 2006 |
Regulation of MLL1 H3K4 methyltransferase activity by its core components.
Topics: Catalytic Domain; Cell Line; DNA-Binding Proteins; Heterotrimeric GTP-Binding Proteins; Histone-Lysine N-Methyltransferase; Histones; Humans; Intracellular Signaling Peptides and Proteins; Lysine; Methylation; Multiprotein Complexes; Myeloid-Lymphoid Leukemia Protein; Nuclear Proteins; Recombinant Proteins; RNA Interference; Transcription Factors | 2006 |
Histone trimethylation and the maintenance of transcriptional ON and OFF states by trxG and PcG proteins.
Topics: Animals; Animals, Genetically Modified; Chromatin; Drosophila melanogaster; Drosophila Proteins; Gene Silencing; Histone-Lysine N-Methyltransferase; Histones; Homeodomain Proteins; Immunoglobulin G; Lysine; Membrane Proteins; Methylation; Nuclear Proteins; Polycomb Repressive Complex 1; Promoter Regions, Genetic; Rabbits; Repressor Proteins; Response Elements; Thioredoxins; Transcription Factors; Transcription, Genetic | 2006 |
Molecular regulation of H3K4 trimethylation by ASH2L, a shared subunit of MLL complexes.
Topics: DNA-Binding Proteins; HeLa Cells; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Models, Biological; Myeloid-Lymphoid Leukemia Protein; Nuclear Proteins; Protein Subunits; Transcription Factors | 2006 |
Selective di- or trimethylation of histone H3 lysine 76 by two DOT1 homologs is important for cell cycle regulation in Trypanosoma brucei.
Topics: 5' Untranslated Regions; Amino Acid Sequence; Animals; Base Sequence; Cell Differentiation; Conserved Sequence; Gene Expression; Genes, Developmental; Histones; Life Cycle Stages; Lysine; Methylation; Mitosis; Molecular Sequence Data; Nucleosomes; Protozoan Proteins; Sequence Alignment; Sequence Homology, Amino Acid; Trypanosoma brucei brucei | 2006 |
Protein interactions within the Set1 complex and their roles in the regulation of histone 3 lysine 4 methylation.
Topics: DNA-Binding Proteins; Gene Expression Regulation, Fungal; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Protein Binding; Protein Subunits; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Transcription Factors | 2006 |
The Yng1p plant homeodomain finger is a methyl-histone binding module that recognizes lysine 4-methylated histone H3.
Topics: Animals; Chromatin; Histone Acetyltransferases; Histones; Lysine; Methylation; Protein Binding; Protein Structure, Tertiary; Recombinant Fusion Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins | 2006 |
Pronuclear stage porcine embryos do not possess a strict asymmetric distribution of lysine 9 dimethylation of histone H3 based solely on parental origin.
Topics: Androgens; Animals; Cell Nucleus; Embryo, Mammalian; Epigenesis, Genetic; Female; Histones; Lysine; Methylation; Parthenogenesis; Sus scrofa; Tissue Distribution | 2007 |
Dynamic regulation of histone modifications in Xenopus oocytes through histone exchange.
Topics: Acetylation; Animals; Chromatin; Chromatin Assembly and Disassembly; DNA Replication; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Hydroxamic Acids; Lysine; Methylation; Oocytes; Protein Methyltransferases; Time Factors; Transcription, Genetic; Xenopus laevis | 2006 |
Structural basis for molecular recognition and presentation of histone H3 by WDR5.
Topics: Amino Acid Sequence; Crystallography, X-Ray; Heterotrimeric GTP-Binding Proteins; Histone-Lysine N-Methyltransferase; Histones; Humans; Hydrogen Bonding; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Lysine; Methylation; Models, Molecular; Molecular Sequence Data; Multiprotein Complexes; Protein Binding; Protein Structure, Tertiary; Recombinant Proteins; Sequence Homology, Amino Acid; Thermodynamics | 2006 |
RIZ1 repression is associated with insulin-like growth factor-1 signaling activation in chronic myeloid leukemia cell lines.
Topics: DNA-Binding Proteins; Gene Expression Regulation; Histone-Lysine N-Methyltransferase; Histones; Humans; Insulin-Like Growth Factor I; K562 Cells; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Lysine; Methylation; Nuclear Proteins; Oligonucleotide Array Sequence Analysis; Promoter Regions, Genetic; Signal Transduction; Transcription Factors | 2007 |
Silencing by plant Polycomb-group genes requires dispersed trimethylation of histone H3 at lysine 27.
Topics: AGAMOUS Protein, Arabidopsis; Alleles; Amino Acid Sequence; Arabidopsis; Arabidopsis Proteins; Carrier Proteins; Cell Nucleus; Cold Temperature; DNA-Binding Proteins; Gene Silencing; Genes, Plant; Histones; Homeodomain Proteins; Lysine; MADS Domain Proteins; Methylation; Mitosis; Models, Genetic; Molecular Sequence Data; Nuclear Proteins; Plant Leaves; Plant Roots; Point Mutation; Polycomb-Group Proteins; Protein Structure, Tertiary; Repressor Proteins; Transgenes | 2006 |
Proline isomerization of histone H3 regulates lysine methylation and gene expression.
Topics: Amino Acid Sequence; Binding Sites; Gene Expression Regulation; Histone Chaperones; Histones; Isomerism; Lysine; Methylation; Models, Molecular; Molecular Sequence Data; Mutation; Oxidoreductases; Proline; Recombinant Proteins; RNA, Messenger; Saccharomyces cerevisiae Proteins; Tacrolimus Binding Proteins; Transcription, Genetic | 2006 |
Fermentation of high concentrations of maltose by Saccharomyces cerevisiae is limited by the COMPASS methylation complex.
Topics: alpha-Glucosidases; Culture Media; Fermentation; Gene Expression Regulation, Fungal; Gene Silencing; Histones; Lysine; Maltose; Methylation; Monosaccharide Transport Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Telomere | 2006 |
Hypoxic stress induces dimethylated histone H3 lysine 9 through histone methyltransferase G9a in mammalian cells.
Topics: Acetylation; Adaptor Proteins, Signal Transducing; Animals; Carrier Proteins; Cell Hypoxia; Cell Line, Tumor; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; Lung Neoplasms; Lysine; Methylation; Mice; MutL Protein Homolog 1; Nuclear Proteins; Promoter Regions, Genetic; Protein Methyltransferases; Protein Processing, Post-Translational; Tetrahydrofolate Dehydrogenase; Transfection | 2006 |
Arginine methylation in a beta-hairpin peptide: implications for Arg-pi interactions, DeltaCp(o), and the cold denatured state.
Topics: Amino Acid Sequence; Arginine; Cold Temperature; Lysine; Methylation; Models, Molecular; Nuclear Magnetic Resonance, Biomolecular; Peptides; Protein Conformation; Protein Denaturation; Protein Folding; Static Electricity; Thermodynamics; Tryptophan | 2006 |
A novel SET domain methyltransferase in yeast: Rkm2-dependent trimethylation of ribosomal protein L12ab at lysine 10.
Topics: Chromatography, Liquid; DNA Methylation; Genotype; Histone-Lysine N-Methyltransferase; Lysine; Mass Spectrometry; Methylation; Methyltransferases; Peptides; Polyribosomes; Protein Structure, Tertiary; Ribosomal Proteins; Ribosomes; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins | 2006 |
The Arabidopsis SUVR4 protein is a nucleolar histone methyltransferase with preference for monomethylated H3K9.
Topics: Alternative Splicing; Amino Acid Sequence; Arabidopsis; Arabidopsis Proteins; Cell Nucleolus; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Molecular Sequence Data; Protein Methyltransferases; Protein Sorting Signals; Protein Structure, Tertiary; Sequence Alignment; Substrate Specificity | 2006 |
Effect of 2MEGA labeling on membrane proteome analysis using LC-ESI QTOF MS.
Topics: Amino Acid Sequence; Cell Membrane; Chromatography, Liquid; Databases, Protein; Escherichia coli; Escherichia coli Proteins; Guanidine; Lysine; Membrane Proteins; Methylation; Molecular Sequence Data; Peptides; Proteome; Sequence Analysis, Protein; Spectrometry, Mass, Electrospray Ionization | 2006 |
Profile of histone lysine methylation across transcribed mammalian chromatin.
Topics: Chromatin; HeLa Cells; Histones; Humans; Lysine; Methylation; Methyltransferases; Poly(A)-Binding Protein I; Transcription, Genetic | 2006 |
Mass spectrometric mapping of linker histone H1 variants reveals multiple acetylations, methylations, and phosphorylation as well as differences between cell culture and tissue.
Topics: Acetylation; Amino Acid Sequence; Animals; Chromatography, Liquid; HeLa Cells; Histones; Humans; Lysine; Mass Spectrometry; Methylation; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Peptide Mapping; Peptides; Phosphorylation; Protein Processing, Post-Translational; Ubiquitin | 2007 |
Methylation of histone H3 at Lys4 differs between paternal and maternal chromosomes in Sciara ocellaris germline development.
Topics: Acetylation; Animals; Cell Nucleus; Chromatin Assembly and Disassembly; Diptera; DNA Polymerase II; Embryo, Nonmammalian; Female; Genomic Imprinting; Germ Cells; Histones; Lysine; Male; Methylation; Phosphorylation; Pupa; X Chromosome | 2006 |
Induction of progesterone target genes requires activation of Erk and Msk kinases and phosphorylation of histone H3.
Topics: Animals; Cell-Free System; Chromatin Assembly and Disassembly; Chromosomal Proteins, Non-Histone; Enzyme Activation; Enzyme Inhibitors; Histones; Lysine; Mammary Tumor Virus, Mouse; Methylation; Mice; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Nucleosomes; Phosphorylation; Progestins; Promoter Regions, Genetic; Protein Binding; Receptors, Progesterone; Ribosomal Protein S6 Kinases, 90-kDa; RNA Polymerase II; Serine; Substrate Specificity; Transcription Factors; Tumor Cells, Cultured | 2006 |
Ctk complex-mediated regulation of histone methylation by COMPASS.
Topics: Chromatin Immunoprecipitation; Cyclin-Dependent Kinases; DNA Polymerase II; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Phosphorylation; Protein Kinases; Proteome; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins | 2007 |
Lysine methylation as a routine rescue strategy for protein crystallization.
Topics: Bacillus anthracis; Biochemistry; Cohort Studies; Computational Biology; Crystallization; Crystallography, X-Ray; Flavivirus; Humans; Lysine; Methylation; Models, Molecular; Murine hepatitis virus; Protein Conformation; Proteins | 2006 |
Isolation and characterization of histone H3 lysine 4 demethylase-containing complexes.
Topics: Cell Line; Chromatography, Affinity; Histones; Humans; Lysine; Methylation; Methyltransferases; Multiprotein Complexes; Oxidoreductases, N-Demethylating; Transfection | 2006 |
Methods to identify and functionally analyze factors that specifically recognize histone lysine methylation.
Topics: Affinity Labels; Animals; Chromatography, Affinity; DNA-Binding Proteins; Gene Expression Regulation; Histones; Lysine; Methylation; Recombinant Proteins; Transcription, Genetic; Xenopus | 2006 |
HP1 binding to chromatin methylated at H3K9 is enhanced by auxiliary factors.
Topics: Animals; Chromatin Assembly and Disassembly; Chromobox Protein Homolog 5; Chromosomal Proteins, Non-Histone; Drosophila; Drosophila Proteins; Heterochromatin; Histones; Lysine; Methylation; Protein Binding; Recombinant Proteins; Repressor Proteins; Transcription Factors | 2007 |
Role of DNA methylation and histone H3 lysine 27 methylation in tissue-specific imprinting of mouse Grb10.
Topics: Animals; Brain; Cell Differentiation; Cells, Cultured; Chromatin Assembly and Disassembly; Crosses, Genetic; DNA Methylation; Epigenesis, Genetic; Genomic Imprinting; GRB10 Adaptor Protein; Histones; Lysine; Methylation; Mice; Neuroglia; Neurons; Polycomb-Group Proteins; Promoter Regions, Genetic; Repressor Proteins | 2007 |
Repression of p53 activity by Smyd2-mediated methylation.
Topics: Animals; Cell Line; Gene Expression Regulation; Histone-Lysine N-Methyltransferase; Humans; Lysine; Methylation; Mice; Tumor Suppressor Protein p53 | 2006 |
Structure of human MRG15 chromo domain and its binding to Lys36-methylated histone H3.
Topics: Amino Acid Sequence; Binding Sites; Crystallography, X-Ray; Histones; Humans; Lysine; Methylation; Models, Molecular; Molecular Sequence Data; Protein Structure, Tertiary; Transcription Factors | 2006 |
Formation of epsilon-formyllysine on silver-stained proteins: implications for assignment of isobaric dimethylation sites by tandem mass spectrometry.
Topics: Amino Acid Sequence; Binding Sites; Formates; Lysine; Methylation; Molecular Sequence Data; Peptides; Proteins; Silver Staining; Tandem Mass Spectrometry | 2007 |
Proteome-wide analysis in Saccharomyces cerevisiae identifies several PHD fingers as novel direct and selective binding modules of histone H3 methylated at either lysine 4 or lysine 36.
Topics: Amino Acid Motifs; Amino Acid Sequence; DNA-Binding Proteins; Histones; Homeodomain Proteins; Lysine; Methylation; Molecular Sequence Data; Protein Binding; Protein Structure, Tertiary; Proteome; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins | 2007 |
Coordinated recruitment of histone methyltransferase G9a and other chromatin-modifying enzymes in SHP-mediated regulation of hepatic bile acid metabolism.
Topics: Acetylation; Amino Acid Sequence; Animals; Chlorocebus aethiops; Cholesterol 7-alpha-Hydroxylase; Cholic Acid; Chromatin; COS Cells; Gene Expression Regulation; Histone Deacetylase Inhibitors; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; Hydroxamic Acids; Liver; Lysine; Male; Methylation; Mice; Molecular Sequence Data; Promoter Regions, Genetic; Protein Binding; Protein Methyltransferases; Protein Transport; Receptors, Cytoplasmic and Nuclear; Steroid 12-alpha-Hydroxylase; Transcription, Genetic | 2007 |
Distinctive signatures of histone methylation in transcribed coding and noncoding human beta-globin sequences.
Topics: Acetylation; Base Sequence; Chromatin; Deoxyribonuclease I; DNA, Intergenic; Epigenesis, Genetic; Globins; Histones; Humans; K562 Cells; Lysine; Methylation; Open Reading Frames; Protein Structure, Tertiary; RNA Polymerase II; RNA, Messenger; Transcription, Genetic | 2007 |
Chromatin remodeling at the Th2 cytokine gene loci in human type 2 helper T cells.
Topics: Acetylation; Chromatin Assembly and Disassembly; Cytokines; Histones; Humans; Interleukin-5; Lysine; Methylation; RNA, Messenger; Th1 Cells; Th2 Cells; Transcription Factors | 2007 |
Histone H3 lysine 36 methylation antagonizes silencing in Saccharomyces cerevisiae independently of the Rpd3S histone deacetylase complex.
Topics: Euchromatin; Gene Silencing; Genes, Dominant; Genes, Mating Type, Fungal; Genetic Testing; Histone Deacetylases; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Methyltransferases; Nuclear Proteins; Point Mutation; Protein Binding; Regulatory Sequences, Nucleic Acid; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Silent Information Regulator Proteins, Saccharomyces cerevisiae; Telomere | 2007 |
Identification of histone H3 lysine 36 acetylation as a highly conserved histone modification.
Topics: Acetylation; Amino Acid Sequence; Animals; Chromatin Immunoprecipitation; Conserved Sequence; Histone Acetyltransferases; Histones; Humans; Lysine; Methylation; Mice; Molecular Sequence Data; Promoter Regions, Genetic; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Tetrahymena | 2007 |
Structural basis for the methylation state-specific recognition of histone H4-K20 by 53BP1 and Crb2 in DNA repair.
Topics: Amino Acid Sequence; Binding Sites; Carrier Proteins; Chromatin; Conserved Sequence; Crystallography, X-Ray; DNA Breaks, Double-Stranded; DNA Repair; Histones; Humans; Intracellular Signaling Peptides and Proteins; Lysine; Magnetic Resonance Spectroscopy; Membrane Proteins; Methylation; Molecular Sequence Data; Mutation; Phosphoproteins; Protein Structure, Tertiary; Tandem Repeat Sequences; Tumor Suppressor p53-Binding Protein 1 | 2006 |
Polycomb-mediated methylation on Lys27 of histone H3 pre-marks genes for de novo methylation in cancer.
Topics: Caco-2 Cells; Carrier Proteins; Cells, Cultured; Colonic Neoplasms; CpG Islands; DNA Methylation; Epigenesis, Genetic; Histones; Humans; Lysine; Methylation; Methyltransferases; Neoplasms; Viral Envelope Proteins | 2007 |
Lysine trimethylation of retinoic acid receptor-alpha: a novel means to regulate receptor function.
Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Base Sequence; Binding Sites; Cell Line; Chlorocebus aethiops; COS Cells; DNA Primers; In Vitro Techniques; Kinetics; Lysine; Methylation; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein Processing, Post-Translational; Proteomics; Receptors, Retinoic Acid; Retinoic Acid Receptor alpha; Spectrometry, Mass, Electrospray Ionization; Spodoptera; Tandem Mass Spectrometry; Two-Hybrid System Techniques | 2007 |
Diversity within the JMJD2 histone demethylase family.
Topics: Blotting, Western; Cell Line; Dimerization; DNA-Binding Proteins; Fluorescent Antibody Technique; Gene Expression Regulation; Histone-Lysine N-Methyltransferase; Histones; Humans; Isoenzymes; Jumonji Domain-Containing Histone Demethylases; Luciferases; Lysine; Matrix Metalloproteinase 1; Methylation; Oxidoreductases, N-Demethylating; Promoter Regions, Genetic; Recombinant Fusion Proteins; Telomerase; Transcription Factors; Transcription, Genetic | 2007 |
The N terminus of Drosophila ESC binds directly to histone H3 and is required for E(Z)-dependent trimethylation of H3 lysine 27.
Topics: Animals; Cattle; Cell Line; Drosophila melanogaster; Drosophila Proteins; Gene Deletion; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Nuclear Proteins; Polycomb Repressive Complex 1; Polycomb Repressive Complex 2; Protein Binding; Repressor Proteins; Substrate Specificity | 2007 |
Linker histone HIS-24 (H1.1) cytoplasmic retention promotes germ line development and influences histone H3 methylation in Caenorhabditis elegans.
Topics: Active Transport, Cell Nucleus; Alleles; Animals; Caenorhabditis elegans; Cell Differentiation; Cell Nucleus; Cell Proliferation; Cytoplasm; Fertilization; Genetic Variation; Germ Cells; Gonads; Histidine; Histones; Lysine; Methylation; Mutation; RNA Interference; Time Factors; Transgenes | 2007 |
Aberrant monomethylation of histone H4 lysine 20 activates the DNA damage checkpoint in Drosophila melanogaster.
Topics: Anaphase-Promoting Complex-Cyclosome; Animals; Apc3 Subunit, Anaphase-Promoting Complex-Cyclosome; Brain; Cell Cycle; Cell Cycle Proteins; Checkpoint Kinase 1; Chromosome Aberrations; Cyclin B; DNA Breaks, Double-Stranded; DNA Damage; Down-Regulation; Drosophila melanogaster; Drosophila Proteins; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Mitosis; Mutation; Neurons; Protein Kinases; Protein Serine-Threonine Kinases; Ubiquitin-Protein Ligase Complexes | 2007 |
Free and chromatin-associated mono-, di-, and trimethylation of histone H4-lysine 20 during development and cell cycle progression.
Topics: Animals; Blotting, Western; Cell Cycle; Cell Fractionation; Chromatin Assembly and Disassembly; Drosophila; Embryonic Development; HeLa Cells; Histones; Humans; Lysine; Methylation; Microscopy, Fluorescence | 2007 |
Methylation of histone H3 lysine-79 by Dot1p plays multiple roles in the response to UV damage in Saccharomyces cerevisiae.
Topics: Adenosine Triphosphatases; Cell Cycle Proteins; DNA; DNA Damage; DNA Helicases; DNA Repair; DNA Replication; Dose-Response Relationship, Radiation; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Nuclear Proteins; Radiation, Ionizing; Recombination, Genetic; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Ultraviolet Rays | 2007 |
Tudor hooks up with DNA repair.
Topics: Animals; Cell Cycle Proteins; Crystallography, X-Ray; DNA Breaks, Double-Stranded; DNA Repair; Histones; Humans; Intracellular Signaling Peptides and Proteins; Lysine; Methylation; Mice; Nuclear Proteins; Protein Binding; Protein Conformation; Protein Structure, Tertiary; Protein Transport; Schizosaccharomyces pombe Proteins; Tumor Suppressor p53-Binding Protein 1 | 2007 |
Reversal of H3K9me2 by a small-molecule inhibitor for the G9a histone methyltransferase.
Topics: Animals; Azepines; Cell Line; Enzyme Inhibitors; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Mice; Promoter Regions, Genetic; Protein Methyltransferases; Quinazolines | 2007 |
Demethylation of trimethylated histone H3 Lys4 in vivo by JARID1 JmjC proteins.
Topics: Animals; DNA-Binding Proteins; Genetic Testing; HeLa Cells; Histone-Lysine N-Methyltransferase; Histones; Humans; Jumonji Domain-Containing Histone Demethylases; Lysine; Methylation; Mice; Mutant Proteins; Neoplasm Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins | 2007 |
Epigenetic reprogramming of OCT4 and NANOG regulatory regions by embryonal carcinoma cell extract.
Topics: Acetylation; Carcinoma, Embryonal; Cell Line; Chromatin Assembly and Disassembly; DNA Methylation; DNA-Binding Proteins; Epigenesis, Genetic; Histones; Homeodomain Proteins; Humans; In Vitro Techniques; Lysine; Methylation; Nanog Homeobox Protein; Octamer Transcription Factor-3; Promoter Regions, Genetic; Protein Processing, Post-Translational; Regulatory Sequences, Nucleic Acid; Tretinoin; Tumor Cells, Cultured; Up-Regulation | 2007 |
The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylases.
Topics: Animals; Cell Line, Tumor; Cell Survival; DNA-Binding Proteins; DNA, Complementary; Gene Library; Histone Demethylases; Histone-Lysine N-Methyltransferase; Histones; Humans; Intracellular Signaling Peptides and Proteins; Jumonji Domain-Containing Histone Demethylases; Lysine; Mental Retardation, X-Linked; Methylation; Mice; Minor Histocompatibility Antigens; Neoplasm Proteins; Neurons; Oxidoreductases, N-Demethylating; Proteins; Retinoblastoma-Binding Protein 2; Tumor Suppressor Proteins | 2007 |
RBP2 belongs to a family of demethylases, specific for tri-and dimethylated lysine 4 on histone 3.
Topics: Amino Acid Sequence; Animals; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Carrier Proteins; DNA-Binding Proteins; Drosophila melanogaster; Embryonic Stem Cells; Gene Deletion; Genes, Homeobox; Histone Demethylases; Histones; Humans; Intracellular Signaling Peptides and Proteins; Jumonji Domain-Containing Histone Demethylases; Lysine; Methylation; Mice; Molecular Sequence Data; Nuclear Proteins; Oxidoreductases, N-Demethylating; Phylogeny; Protein Structure, Tertiary; Proteins; Repressor Proteins; Retinoblastoma-Binding Protein 2; Schizosaccharomyces; Sequence Alignment; Tumor Suppressor Proteins | 2007 |
Epigenetic regulation of facultative heterochromatinisation in Planococcus citri via the Me(3)K9H3-HP1-Me(3)K20H4 pathway.
Topics: Animals; Chromosome Aberrations; Embryo, Nonmammalian; Epigenesis, Genetic; Genomic Imprinting; Hemiptera; Heterochromatin; Histones; Insect Proteins; Lysine; Male; Metaphase; Methylation; Nuclear Proteins; RNA, Double-Stranded; Signal Transduction | 2007 |
Aldosterone-induced Sgk1 relieves Dot1a-Af9-mediated transcriptional repression of epithelial Na+ channel alpha.
Topics: Aldosterone; Animals; Cells, Cultured; Down-Regulation; Epithelial Sodium Channels; Female; Gene Expression Regulation; Histone-Lysine N-Methyltransferase; Histones; Immediate-Early Proteins; Kidney Tubules, Collecting; Lysine; Methylation; Methyltransferases; Mice; Mice, Knockout; Mutation; Nuclear Proteins; Phosphorylation; Promoter Regions, Genetic; Protein Serine-Threonine Kinases; Protein Transport; RNA, Messenger; Serine; Sodium Chloride; Transcription, Genetic | 2007 |
Coordinated change of a ratio of methylated H3-lysine 4 or acetylated H3 to acetylated H4 and DNA methylation is associated with tissue-specific gene expression in cloned pig.
Topics: Acetylation; Animals; Animals, Genetically Modified; Cells, Cultured; DNA Methylation; Ear; Fibroblasts; Gene Expression; Gene Silencing; Histone Deacetylases; Histones; Lysine; Methylation; Organ Specificity; Swine; Transgenes | 2007 |
Kinetic manifestation of processivity during multiple methylations catalyzed by SET domain protein methyltransferases.
Topics: Adenosine; Animals; Catalysis; Cattle; Cell Cycle Proteins; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Kinetics; Lysine; Methylation; Methyltransferases; Models, Chemical; Multienzyme Complexes; Pisum sativum; Plant Proteins; Protein Methyltransferases; Protein Structure, Tertiary; S-Adenosylhomocysteine; Schizosaccharomyces pombe Proteins | 2007 |
Genome-wide analysis of histone lysine methylation variations caused by diabetic conditions in human monocytes.
Topics: Cell Line; CpG Islands; Diabetes Mellitus; Gene Expression Profiling; Gene Expression Regulation; Genome, Human; Glucose; Histones; Humans; Lysine; Methylation; Monocytes; Oligonucleotide Array Sequence Analysis; Protein Array Analysis; Protein Processing, Post-Translational; RNA, Messenger; Sweetening Agents | 2007 |
The polycomb group protein Suz12 is required for embryonic stem cell differentiation.
Topics: Animals; Cell Differentiation; Cells, Cultured; Chromatin Immunoprecipitation; DNA-Binding Proteins; Embryonic Stem Cells; Gene Expression Regulation, Developmental; Histones; Homeodomain Proteins; Lysine; Methylation; Mice; Mice, Knockout; Multiprotein Complexes; Nanog Homeobox Protein; Neurons; Octamer Transcription Factor-3; Polycomb Repressive Complex 2; Promoter Regions, Genetic; Repressor Proteins; Transcription, Genetic | 2007 |
The site-specific installation of methyl-lysine analogs into recombinant histones.
Topics: Animals; Cysteine; Histones; Lysine; Methylation; Models, Molecular; Nucleosomes; Recombinant Proteins; Xenopus Proteins | 2007 |
The trithorax-group gene in Drosophila little imaginal discs encodes a trimethylated histone H3 Lys4 demethylase.
Topics: Animals; Chromosomes; DNA-Binding Proteins; Drosophila melanogaster; Drosophila Proteins; Histone Demethylases; Histone-Lysine N-Methyltransferase; Histones; Larva; Lysine; Methylation; Protein Binding; RNA Interference; Sequence Homology, Amino Acid; Transcription Factors | 2007 |
The trithorax-group protein Lid is a histone H3 trimethyl-Lys4 demethylase.
Topics: Animals; DNA-Binding Proteins; Drosophila melanogaster; Drosophila Proteins; Histone Demethylases; Histone-Lysine N-Methyltransferase; Histones; Larva; Lysine; Methylation; Mutant Proteins; Protein Structure, Tertiary; Protein Transport; RNA Polymerase II; Substrate Specificity; Transcription Factors | 2007 |
trans-2-Phenylcyclopropylamine is a mechanism-based inactivator of the histone demethylase LSD1.
Topics: Amino Acid Sequence; Catalytic Domain; Enzyme Inhibitors; Escherichia coli; Flavins; Histone Demethylases; Humans; Hydrogen-Ion Concentration; Kinetics; Lysine; Mass Spectrometry; Methylation; Models, Biological; Molecular Sequence Data; Molecular Structure; Monoamine Oxidase Inhibitors; Oxidoreductases, N-Demethylating; Protein Structure, Tertiary; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Temperature; Tranylcypromine | 2007 |
Identification of histone demethylases in Saccharomyces cerevisiae.
Topics: Acetylation; Amino Acid Sequence; Genetic Complementation Test; Histone Demethylases; Histone-Lysine N-Methyltransferase; Histones; Jumonji Domain-Containing Histone Demethylases; Lysine; Mass Spectrometry; Methylation; Molecular Sequence Data; Mutagenesis, Site-Directed; Oxidoreductases, N-Demethylating; Phenotype; Repressor Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sequence Homology, Amino Acid | 2007 |
Demethylation of histone H3K36 and H3K9 by Rph1: a vestige of an H3K9 methylation system in Saccharomyces cerevisiae?
Topics: Histone Demethylases; Histones; Lysine; Methylation; Phenotype; Protein Structure, Tertiary; Recombinant Proteins; Repressor Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins | 2007 |
Stability of antimicrobial decapeptide (KSL) and its analogues for delivery in the oral cavity.
Topics: Administration, Oral; Amino Acid Sequence; Antimicrobial Cationic Peptides; Bacteria; Chewing Gum; Chromatography, High Pressure Liquid; Dental Plaque; Depsipeptides; Drug Stability; Gastric Juice; Humans; Kinetics; Lysine; Mass Spectrometry; Methylation; Microbial Sensitivity Tests; Saliva | 2007 |
Ab initio quantum mechanical/molecular mechanical molecular dynamics simulation of enzyme catalysis: the case of histone lysine methyltransferase SET7/9.
Topics: Catalysis; Computer Simulation; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Hydrogen Bonding; Lysine; Methylation; Models, Chemical; Models, Molecular; Protein Methyltransferases; Quantum Theory; Solutions; Structure-Activity Relationship; Thermodynamics | 2007 |
Regulation of histone H3K4 tri-methylation and PAF complex recruitment by the Ccr4-Not complex.
Topics: Cyclin-Dependent Kinases; Cyclins; DNA-Binding Proteins; DNA-Directed RNA Polymerases; Gene Deletion; Gene Expression Regulation, Fungal; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Nuclear Proteins; Repressor Proteins; Ribonucleases; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Transcription Factors; Ubiquitin; Ubiquitin-Protein Ligases | 2007 |
Effects of chain length and N-methylation on a cation-pi interaction in a beta-hairpin peptide.
Topics: Amino Acid Motifs; Aminobutyrates; Cations; Hydrogen-Ion Concentration; Lysine; Magnetic Resonance Spectroscopy; Methylation; Models, Molecular; Molecular Structure; Ornithine; Peptides; Thermodynamics | 2007 |
Whole-genome analysis of histone H3 lysine 27 trimethylation in Arabidopsis.
Topics: Amino Acid Sequence; Arabidopsis; Gene Silencing; Genes, Plant; Genome, Plant; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation | 2007 |
The role of histone ubiquitylation and deubiquitylation in gene expression as determined by the analysis of an HTB1(K123R) Saccharomyces cerevisiae strain.
Topics: Amino Acid Substitution; Amino Acid Transport Systems; Arginine; Endopeptidases; Gene Expression Regulation, Fungal; Histone-Lysine N-Methyltransferase; Histones; Lysine; Membrane Glycoproteins; Methylation; Mutation; Nuclear Proteins; Oligonucleotide Array Sequence Analysis; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Transcription Factors; Ubiquitin | 2007 |
Mimicking methylated histones.
Topics: Amino Acid Sequence; Histones; Lysine; Methylation | 2007 |
Mass spectrometric analysis of high-mobility group proteins and their post-translational modifications in normal and cancerous human breast tissues.
Topics: Amino Acid Sequence; Breast; Breast Neoplasms; Female; HMGA1a Protein; HMGA1b Protein; Humans; Lysine; Methylation; Molecular Sequence Data; Protein Processing, Post-Translational; Serine; Tandem Mass Spectrometry | 2007 |
The Saccharomyces cerevisiae histone demethylase Jhd1 fine-tunes the distribution of H3K36me2.
Topics: Amino Acid Sequence; Gene Deletion; HeLa Cells; Histones; Humans; Iron; Jumonji Domain-Containing Histone Demethylases; Ketoglutaric Acids; Lysine; Methylation; Molecular Sequence Data; Open Reading Frames; Oxidoreductases, N-Demethylating; Phenotype; Protein Binding; Protein Structure, Tertiary; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins | 2007 |
PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex.
Topics: Animals; Carrier Proteins; Cell Line, Transformed; DNA Damage; DNA-Binding Proteins; HeLa Cells; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Mice; Mice, Knockout; Multiprotein Complexes; Nuclear Proteins; Protein Methyltransferases; Protein Processing, Post-Translational | 2007 |
Mechanism of histone methylation catalyzed by protein lysine methyltransferase SET7/9 and origin of product specificity.
Topics: Binding Sites; Catalysis; Computer Simulation; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Models, Molecular; Mutation; Protein Binding; Protein Methyltransferases; Protein Structure, Tertiary; Protons; Sensitivity and Specificity; Substrate Specificity; Tyrosine | 2007 |
Diverse histone modifications on histone 3 lysine 9 and their relation to DNA methylation in specifying gene silencing.
Topics: Acetylation; Animals; Azacitidine; Cell Line, Tumor; Chromatin Immunoprecipitation; CpG Islands; Decitabine; DNA Methylation; DNA Modification Methylases; Gene Expression Regulation; Gene Silencing; Histones; Hydroxamic Acids; Leukemia L1210; Lysine; Methylation; Mice; Mice, Inbred DBA; Oligonucleotide Array Sequence Analysis; Protein Processing, Post-Translational | 2007 |
Two Saccharomyces cerevisiae JmjC domain proteins demethylate histone H3 Lys36 in transcribed regions to promote elongation.
Topics: Catalysis; Chromatin; Chromatin Immunoprecipitation; DNA Methylation; Histone Demethylases; Histones; Jumonji Domain-Containing Histone Demethylases; Lysine; Methylation; Oxidoreductases, N-Demethylating; Protein Binding; Protein Structure, Tertiary; Repressor Proteins; RNA Polymerase II; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Transcription, Genetic | 2007 |
Arabidopsis TFL2/LHP1 specifically associates with genes marked by trimethylation of histone H3 lysine 27.
Topics: Arabidopsis; Arabidopsis Proteins; Chromosomal Proteins, Non-Histone; Euchromatin; Gene Expression Regulation, Plant; Genes, Plant; Histones; Lysine; Methylation; Molecular Sequence Data; Polycomb-Group Proteins; Repressor Proteins | 2007 |
H2B-K123 ubiquitination stimulates RNAPII elongation independent of H3-K4 methylation.
Topics: Chromatin Immunoprecipitation; Epigenesis, Genetic; Gene Expression Regulation; Histones; Kinetics; Lysine; Methylation; Models, Biological; Models, Genetic; RNA Polymerase II; Saccharomyces cerevisiae; Time Factors; Transcription, Genetic; Ubiquitin | 2007 |
Trithorax-group protein ASH1 methylates histone H3 lysine 36.
Topics: Amino Acid Sequence; Animals; Base Sequence; Binding Sites; DNA Primers; DNA-Binding Proteins; Drosophila; Drosophila Proteins; Genes, Insect; Histones; In Vitro Techniques; Lysine; Methylation; Mice; Mutagenesis, Site-Directed; Nucleosomes; Recombinant Proteins; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Transcription Factors | 2007 |
The induction of H3K9 methylation by PIWIL4 at the p16Ink4a locus.
Topics: Argonaute Proteins; Cell Line; Cyclin-Dependent Kinase Inhibitor p16; Gene Expression Regulation; Histones; Humans; Lysine; Methylation; Proteins; RNA-Binding Proteins | 2007 |
The fission yeast Jmj2 reverses histone H3 Lysine 4 trimethylation.
Topics: Gene Deletion; Genome, Fungal; Histones; Lysine; Methylation; Oligonucleotide Array Sequence Analysis; Polymerase Chain Reaction; Promoter Regions, Genetic; Recombinant Proteins; Schizosaccharomyces; Schizosaccharomyces pombe Proteins; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2007 |
The triploid endosperm genome of Arabidopsis adopts a peculiar, parental-dosage-dependent chromatin organization.
Topics: Arabidopsis; Centromere; Chromatin; Chromosomes, Plant; DNA, Ribosomal; Gene Dosage; Genome, Plant; Heterochromatin; Histones; Lysine; Meristem; Methylation; Models, Genetic; Plant Leaves; Polyploidy; Seeds | 2007 |
Drosophila dSet2 functions in H3-K36 methylation and is required for development.
Topics: Animals; Drosophila melanogaster; Drosophila Proteins; Gene Expression Regulation, Developmental; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Phosphorylation; Protein Binding; Receptors, Steroid; RNA Polymerase II | 2007 |
SET8-mediated methylations of histone H4 lysine 20 mark silent heterochromatic domains in apicomplexan genomes.
Topics: Amino Acid Sequence; Amino Acids; Animals; Catalysis; Catalytic Domain; Cell Cycle; Gene Silencing; Genome, Protozoan; Heterochromatin; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Models, Molecular; Molecular Sequence Data; Mutation; Parasites; Phylogeny; Protozoan Proteins; Toxoplasma | 2007 |
Post-translational modifications in the rat lumbar spinal cord in experimental autoimmune encephalomyelitis.
Topics: Amino Acid Sequence; Animals; Arginine; Astrocytes; Citrulline; Encephalomyelitis, Autoimmune, Experimental; Glial Fibrillary Acidic Protein; Lumbar Vertebrae; Lysine; Methylation; Molecular Sequence Data; Multiple Sclerosis; Phosphorylation; Protein Processing, Post-Translational; Proteomics; Rats; Serine; Spinal Cord | 2007 |
Epigenetic and genetic mechanisms contribute to telomerase inhibition by EGCG.
Topics: Adenocarcinoma; Apoptosis; Breast Neoplasms; Catechin; Cell Division; Cell Line, Tumor; DNA Methylation; E2F1 Transcription Factor; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Histones; HL-60 Cells; Humans; Lysine; Male; Methylation; Neoplasm Proteins; Promoter Regions, Genetic; Protein Processing, Post-Translational; RNA, Messenger; RNA, Neoplasm; Telomerase | 2008 |
RBP2 is an MRG15 complex component and down-regulates intragenic histone H3 lysine 4 methylation.
Topics: Cell Line; Down-Regulation; Gene Expression Regulation, Fungal; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Models, Biological; Models, Genetic; Phosphorylation; Retinol-Binding Proteins; Retinol-Binding Proteins, Cellular; Saccharomyces cerevisiae; Serine; Transcription Factors; Transcription, Genetic | 2007 |
Recognition of trimethyllysine by a chromodomain is not driven by the hydrophobic effect.
Topics: Amino Acid Sequence; Histones; Hydrophobic and Hydrophilic Interactions; Lysine; Methylation; Molecular Sequence Data; Protein Binding; Protein Structure, Tertiary; Thermodynamics | 2007 |
Transcriptionally active heterochromatin in rye B chromosomes.
Topics: Cell Nucleus; Chromosomes, Plant; DNA, Plant; Gene Expression Regulation, Plant; Genome, Plant; Heterochromatin; Histones; Interphase; Lysine; Methylation; Molecular Sequence Data; Organ Specificity; Polyadenylation; Repetitive Sequences, Nucleic Acid; Secale; Transcription, Genetic | 2007 |
Functional dynamics of H3K9 methylation during meiotic prophase progression.
Topics: Animals; Cell Lineage; Female; Gene Deletion; Gene Expression Regulation; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Infertility; Integrases; Jumonji Domain-Containing Histone Demethylases; Kinetics; Lysine; Male; Meiotic Prophase I; Methylation; Mice; Mice, Knockout; Ovary; Oxidoreductases, N-Demethylating; Pachytene Stage; Protein Methyltransferases; Spermatocytes; Spermatogonia | 2007 |
Widespread, exceptionally high levels of histone H3 lysine 4 trimethylation largely mediate "privileged" gene expression.
Topics: Cell Line, Tumor; Gene Expression; Gene Silencing; Histones; Humans; Keratin-8; Lysine; Methylation; Promoter Regions, Genetic; RNA, Messenger; RNA, Small Interfering | 2007 |
Novel eye-specific calmodulin methylation characterized by protein mapping in Drosophila melanogaster.
Topics: Amino Acid Sequence; Animals; Calmodulin; Databases, Protein; Drosophila melanogaster; Electrophoresis, Gel, Two-Dimensional; Eye; Lysine; Male; Mass Spectrometry; Methylation; Models, Molecular; Molecular Sequence Data; Molecular Weight; Peptide Mapping; Proteomics; RNA, Messenger; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Trypsin | 2007 |
(NZ)CH...O contacts assist crystallization of a ParB-like nuclease.
Topics: Bacterial Proteins; Crystallography, X-Ray; Deoxyribonucleases; DNA Primase; Endodeoxyribonucleases; Escherichia coli Proteins; Exodeoxyribonucleases; Lysine; Methylation; Models, Molecular; Protein Structure, Secondary; Protein Structure, Tertiary; Pyrococcus furiosus; Thermodynamics | 2007 |
Dynamic regulation of histone H3 methylation at lysine 4 in mammalian spermatogenesis.
Topics: Animals; Callithrix; Histone Deacetylase 1; Histone Deacetylases; Histone Demethylases; Histones; Lysine; Male; Methylation; Mice; Oxidoreductases, N-Demethylating; Spermatogenesis; Testis | 2007 |
Polypeptide substrate specificity of PsLSMT. A set domain protein methyltransferase.
Topics: alpha-Tocopherol; Catalysis; Histone-Lysine N-Methyltransferase; Kinetics; Lysine; Methylation; Methyltransferases; Nicotiana; Peptides; Perilla frutescens; Protein Methyltransferases; Protein Structure, Tertiary; Ribulose-Bisphosphate Carboxylase; RNA Interference; Substrate Specificity | 2007 |
Analysis of dynamic changes in post-translational modifications of human histones during cell cycle by mass spectrometry.
Topics: Acetylation; Amino Acid Sequence; Cell Cycle; Histones; Humans; Isotope Labeling; Lysine; Mass Spectrometry; Methylation; Molecular Sequence Data; Peptides; Protein Processing, Post-Translational | 2007 |
Methylation-acetylation interplay activates p53 in response to DNA damage.
Topics: Acetylation; Cell Cycle; Cell Line; Cyclin-Dependent Kinase Inhibitor p21; DNA Damage; Gene Expression Regulation; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Promoter Regions, Genetic; Protein Methyltransferases; Protein Processing, Post-Translational; RNA; Tumor Suppressor Protein p53 | 2007 |
Global assessment of combinatorial post-translational modification of core histones in yeast using contemporary mass spectrometry. LYS4 trimethylation correlates with degree of acetylation on the same H3 tail.
Topics: Acetylation; Amino Acid Sequence; Chromatin; Chromatography, High Pressure Liquid; Histones; Lysine; Mass Spectrometry; Methylation; Models, Biological; Molecular Sequence Data; Protein Processing, Post-Translational; Proteomics; Saccharomyces cerevisiae; Serine Endopeptidases | 2007 |
Expansion of chromosome territories with chromatin decompaction in BAF53-depleted interphase cells.
Topics: Acetylation; Actins; Animals; Cell Cycle Proteins; Chromatin; Chromosomal Proteins, Non-Histone; Chromosomes, Mammalian; DNA Helicases; DNA-Binding Proteins; Down-Regulation; Histones; Interphase; Lysine; Methylation; Mice; NIH 3T3 Cells; Nuclear Proteins; Nucleosomes; Repetitive Sequences, Nucleic Acid; Transcription Factors; Up-Regulation | 2007 |
Retinoid regulated association of transcriptional co-regulators and the polycomb group protein SUZ12 with the retinoic acid response elements of Hoxa1, RARbeta(2), and Cyp26A1 in F9 embryonal carcinoma cells.
Topics: Acetylation; Animals; Base Sequence; Cell Line, Tumor; Cytochrome P-450 Enzyme System; Gene Expression Regulation; Histone Acetyltransferases; Histones; Homeodomain Proteins; Kinetics; Lysine; Methylation; Molecular Sequence Data; Nuclear Receptor Coactivator 3; p300-CBP Transcription Factors; Polycomb-Group Proteins; Protein Binding; Receptors, Retinoic Acid; Repressor Proteins; Response Elements; Retinoic Acid 4-Hydroxylase; Retinoid X Receptors; RNA Polymerase II; RNA, Messenger; Trans-Activators; Transcription Factors; Transcription, Genetic; Tretinoin | 2007 |
Simultaneous mutation of methylated lysine residues in histone H3 causes enhanced gene silencing, cell cycle defects, and cell lethality in Saccharomyces cerevisiae.
Topics: Cell Cycle; Gene Expression Profiling; Gene Expression Regulation, Fungal; Gene Silencing; Heterochromatin; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Mutagenesis, Site-Directed; Mutation; Nucleosomes; Phenotype; Protein Methyltransferases; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Silent Information Regulator Proteins, Saccharomyces cerevisiae; Telomere | 2007 |
The JMJD2 members of histone demethylase revisited.
Topics: Amino Acid Sequence; Histones; Lysine; Methylation; Models, Molecular; Molecular Sequence Data; Oxidoreductases, N-Demethylating; Protein Conformation | 2008 |
Targeting the JMJD2A histone lysine demethylase.
Topics: Chromatin Assembly and Disassembly; Epigenesis, Genetic; Histones; Humans; Jumonji Domain-Containing Histone Demethylases; Lysine; Methylation; Oxidoreductases, N-Demethylating; Substrate Specificity | 2007 |
The Arabidopsis LHP1 protein colocalizes with histone H3 Lys27 trimethylation.
Topics: Arabidopsis; Chromosomal Proteins, Non-Histone; Histones; Lysine; Methylation | 2007 |
Recognition of unmethylated histone H3 lysine 4 links BHC80 to LSD1-mediated gene repression.
Topics: Amino Acid Sequence; Chromatin; Gene Silencing; HeLa Cells; Histone Deacetylases; Histone Demethylases; Histones; Humans; Lysine; Methylation; Models, Molecular; Molecular Sequence Data; Oxidoreductases, N-Demethylating; Protein Structure, Tertiary; RNA Interference; Zinc Fingers | 2007 |
Implications of a histone code mimic in epigenetic signaling.
Topics: Animals; Epigenesis, Genetic; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Mice; Molecular Mimicry; Protein Methyltransferases; Signal Transduction; Substrate Specificity | 2007 |
Modulation of p53 function by SET8-mediated methylation at lysine 382.
Topics: Amino Acid Sequence; Antibodies; Cell Line, Tumor; DNA Damage; Histone-Lysine N-Methyltransferase; Humans; Lysine; Methylation; Models, Biological; Molecular Sequence Data; RNA Interference; Substrate Specificity; Transcriptional Activation; Tumor Suppressor Protein p53 | 2007 |
Class I histone deacetylase Thd1p promotes global chromatin condensation in Tetrahymena thermophila.
Topics: Acetates; Acetylation; Animals; Chromatin; Chromatin Assembly and Disassembly; Food Deprivation; Histone Deacetylases; Histones; Lysine; Macronucleus; Methylation; Mutation; Phosphorylation; Tetrahymena thermophila | 2007 |
Demethylation of H3K27 regulates polycomb recruitment and H2A ubiquitination.
Topics: Cell Differentiation; Cell Line; Cell Line, Tumor; DNA-Binding Proteins; Embryonic Stem Cells; Genes, Homeobox; Histone Demethylases; Histones; Humans; Lysine; Methylation; Multigene Family; Neoplasm Proteins; Nuclear Proteins; Polycomb-Group Proteins; Promoter Regions, Genetic; Protein Processing, Post-Translational; Recombinant Proteins; Repressor Proteins; Signal Transduction; Transcription, Genetic; Transcriptional Activation; Tretinoin; Ubiquitin | 2007 |
Pcl-PRC2 is needed to generate high levels of H3-K27 trimethylation at Polycomb target genes.
Topics: Animals; Cell Extracts; Drosophila melanogaster; Drosophila Proteins; Embryo, Nonmammalian; Genes, Insect; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Polycomb-Group Proteins; Protein Methyltransferases; Repressor Proteins; Substrate Specificity | 2007 |
Dynamic reprogramming of histone acetylation and methylation in the first cell cycle of cloned mouse embryos.
Topics: Acetylation; Animals; Cell Cycle; Cloning, Organism; Embryo, Mammalian; Female; Histone Acetyltransferases; Histone Deacetylase Inhibitors; Histones; Hydroxamic Acids; Lysine; Male; Methylation; Methyltransferases; Mice; Sperm Injections, Intracytoplasmic | 2007 |
Distinct methylation patterns in histone H3 at Lys-4 and Lys-9 correlate with up- & down-regulation of genes by ethanol in hepatocytes.
Topics: Animals; Gene Expression Regulation; Hepatocytes; Histones; Immunohistochemistry; Lysine; Male; Methylation; Promoter Regions, Genetic; Rats; Rats, Sprague-Dawley | 2007 |
Spatial distribution of histone methylation during MHC class II expression.
Topics: Acetylation; Animals; B-Lymphocytes; Cell Line; Gene Expression Regulation; Histocompatibility Antigens Class II; Histone Deacetylases; Histones; Humans; Hydroxamic Acids; Interferon-gamma; Lysine; Methylation; Mice; Nuclear Proteins; Promoter Regions, Genetic; Trans-Activators | 2008 |
A histone H3 lysine 27 demethylase regulates animal posterior development.
Topics: Animals; Body Patterning; Cell Line; Embryo, Nonmammalian; Gene Expression Regulation, Developmental; Genes, Homeobox; Genome; Histone Demethylases; Histones; Humans; Jumonji Domain-Containing Histone Demethylases; Lysine; Methylation; Mice; Nuclear Proteins; Oxidoreductases, N-Demethylating; Transcription, Genetic; Zebrafish; Zebrafish Proteins | 2007 |
Histone H3 K4 demethylation during activation and attenuation of GAL1 transcription in Saccharomyces cerevisiae.
Topics: Animals; beta-Fructofuranosidase; DNA-Binding Proteins; Enzyme Activation; Galactokinase; Gene Expression Regulation, Fungal; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Oxidoreductases, N-Demethylating; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Substrate Specificity; Transcription Factors; Transcription, Genetic; Transcriptional Activation | 2007 |
The Arabidopsis homologs of trithorax (ATX1) and enhancer of zeste (CLF) establish 'bivalent chromatin marks' at the silent AGAMOUS locus.
Topics: AGAMOUS Protein, Arabidopsis; Arabidopsis; Arabidopsis Proteins; Gene Expression Regulation, Plant; Gene Silencing; Histone-Lysine N-Methyltransferase; Histones; Homeodomain Proteins; Lysine; Methylation; Mutation; Nucleosomes; Phenotype; Transcription Factors | 2007 |
Selective anchoring of TFIID to nucleosomes by trimethylation of histone H3 lysine 4.
Topics: Acetylation; Amino Acid Sequence; Animals; Gene Expression Regulation; HeLa Cells; Histones; Homeodomain Proteins; Humans; Lysine; Macromolecular Substances; Methylation; Mice; Molecular Sequence Data; Nucleosomes; Recombinant Fusion Proteins; RNA, Messenger; Transcription Factor TFIID; Tumor Suppressor Proteins; Zinc Fingers | 2007 |
Methylation of histone H3R2 by PRMT6 and H3K4 by an MLL complex are mutually exclusive.
Topics: Animals; Arginine; Cell Line; Cell Line, Tumor; Chromatin Immunoprecipitation; DNA-Binding Proteins; Embryo, Mammalian; Epigenesis, Genetic; Gene Expression Regulation; Histone-Lysine N-Methyltransferase; Histones; Humans; Intracellular Signaling Peptides and Proteins; Lysine; Methylation; Mice; Multiprotein Complexes; Nuclear Proteins; Promoter Regions, Genetic; Protein-Arginine N-Methyltransferases; Transcription Factors | 2007 |
Arginine methylation at histone H3R2 controls deposition of H3K4 trimethylation.
Topics: Arginine; Chromatin Immunoprecipitation; DNA-Binding Proteins; Euchromatin; Gene Expression Regulation, Fungal; Genes, Fungal; Genome, Fungal; Heterochromatin; Histone Deacetylases; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Protein Subunits; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Shelterin Complex; Silent Information Regulator Proteins, Saccharomyces cerevisiae; Sirtuin 2; Sirtuins; Telomere-Binding Proteins; Transcription Factors | 2007 |
Mammalian ASH1L is a histone methyltransferase that occupies the transcribed region of active genes.
Topics: Animals; Base Sequence; Chromatin; DNA-Binding Proteins; Gene Expression Regulation; Genes, Essential; HeLa Cells; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Homeodomain Proteins; Humans; K562 Cells; Lysine; Mammals; Methylation; Mice; Myeloid-Lymphoid Leukemia Protein; Protein Binding; Protein Methyltransferases; Protein Structure, Tertiary; Transcription Factors; Transcription, Genetic | 2007 |
JMJD3 is a histone H3K27 demethylase.
Topics: Binding Sites; Blotting, Western; Databases, Factual; DNA-Binding Proteins; Glutathione Transferase; HeLa Cells; Histones; Humans; Immunohistochemistry; Jumonji Domain-Containing Histone Demethylases; Lysine; Male; Methylation; Mutation; Neoplasm Metastasis; Oxidoreductases, N-Demethylating; Prostatic Neoplasms; Recombinant Fusion Proteins; Transfection | 2007 |
The BRCT-domain containing protein PTIP links PAX2 to a histone H3, lysine 4 methyltransferase complex.
Topics: Animals; Carrier Proteins; Cell Line; DNA-Binding Proteins; Epigenesis, Genetic; Gastrulation; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Mice; Nuclear Proteins; PAX2 Transcription Factor; Protein Binding; Protein Methyltransferases; Protein Structure, Tertiary | 2007 |
SMRT-mediated repression of an H3K27 demethylase in progression from neural stem cell to neuron.
Topics: Animals; Cell Differentiation; Cell Line, Tumor; Cells, Cultured; DNA-Binding Proteins; Embryo, Mammalian; Embryonal Carcinoma Stem Cells; Histones; Humans; Jumonji Domain-Containing Histone Demethylases; Lysine; Methylation; Mice; Neurons; Nuclear Receptor Co-Repressor 2; Oxidoreductases, N-Demethylating; Rats; Repressor Proteins; Stem Cells | 2007 |
Structural and functional analyses of methyl-lysine binding by the malignant brain tumour repeat protein Sex comb on midleg.
Topics: Amino Acid Sequence; Animals; Crystallography, X-Ray; DNA-Binding Proteins; Drosophila melanogaster; Drosophila Proteins; Gene Expression Regulation, Developmental; Genes, Homeobox; Histones; Lysine; Methylation; Models, Molecular; Molecular Sequence Data; Peptides; Polycomb Repressive Complex 1; Polycomb-Group Proteins; Protein Conformation; Protein Structure, Tertiary; Repressor Proteins; Sequence Alignment; Transgenes | 2007 |
CHD8 associates with human Staf and contributes to efficient U6 RNA polymerase III transcription.
Topics: Amino Acid Sequence; Chromatin; DNA-Binding Proteins; HeLa Cells; Histones; Humans; Immunoprecipitation; Interferon Regulatory Factor-3; Lysine; Methylation; Molecular Sequence Data; Protein Binding; Protein Transport; RNA Polymerase III; RNA, Small Nuclear; Trans-Activators; Transcription Factors; Transcription, Genetic; Transcriptional Activation | 2007 |
Automethylation of G9a and its implication in wider substrate specificity and HP1 binding.
Topics: Amino Acid Motifs; Amino Acid Sequence; Animals; Cell Line; Chlorocebus aethiops; Chromobox Protein Homolog 5; Chromosomal Proteins, Non-Histone; COS Cells; Histone-Lysine N-Methyltransferase; Lysine; Mass Spectrometry; Methylation; Mice; Molecular Sequence Data; Mutation; Protein Processing, Post-Translational; Substrate Specificity | 2007 |
Certain and progressive methylation of histone H4 at lysine 20 during the cell cycle.
Topics: Acetylation; Cell Cycle; Gene Deletion; Gene Expression Regulation; HeLa Cells; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Mass Spectrometry; Methylation | 2008 |
ICBP90, a novel methyl K9 H3 binding protein linking protein ubiquitination with heterochromatin formation.
Topics: Amino Acid Motifs; CCAAT-Enhancer-Binding Proteins; Cell Nucleus; Chromobox Protein Homolog 5; Chromosomal Proteins, Non-Histone; Gene Expression Regulation; HeLa Cells; Heterochromatin; Histones; Humans; Interphase; Lysine; Methylation; Protein Binding; RNA, Small Interfering; Signal Transduction; Ubiquitin-Protein Ligases; Ubiquitination | 2008 |
Differentially expressed genes are marked by histone 3 lysine 9 trimethylation in human cancer cells.
Topics: Cell Line, Tumor; DNA Methylation; Gene Expression Regulation, Neoplastic; Histones; Homeodomain Proteins; Humans; Lysine; Methylation; Myeloid Ecotropic Viral Integration Site 1 Protein; Neoplasm Proteins; Neoplasms; Otx Transcription Factors; Transcription, Genetic | 2008 |
Vernalization-induced trimethylation of histone H3 lysine 27 at FLC is not maintained in mitotically quiescent cells.
Topics: Arabidopsis; Arabidopsis Proteins; Cold Temperature; Histones; Interphase; Lysine; MADS Domain Proteins; Methylation; Plant Leaves | 2007 |
Identification of JmjC domain-containing UTX and JMJD3 as histone H3 lysine 27 demethylases.
Topics: Animals; Catalysis; Cell Line; Chlorocebus aethiops; Gene Expression Regulation, Enzymologic; Histone Demethylases; Histones; Humans; Jumonji Domain-Containing Histone Demethylases; Lysine; Methylation; Mice; Mutation; Nuclear Proteins; Oxidoreductases, N-Demethylating; Protein Structure, Tertiary; Substrate Specificity; Transcriptional Activation | 2007 |
Changes in H3K79 methylation during preimplantation development in mice.
Topics: Animals; Biomarkers; Cleavage Stage, Ovum; Embryonic Development; Female; Fertilization; Gene Expression Regulation, Developmental; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Lysine; Male; Meiosis; Methylation; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Protein Methyltransferases; Tissue Distribution | 2008 |
Epigenetics: reversing the 'irreversible'.
Topics: Animals; Brain; Cell Differentiation; DNA-Binding Proteins; Gene Silencing; Histones; Humans; Jumonji Domain-Containing Histone Demethylases; Lysine; Methylation; Mice; Nuclear Receptor Co-Repressor 2; Oxidoreductases, N-Demethylating; Polycomb-Group Proteins; Repressor Proteins | 2007 |
The lysine 831 of vascular endothelial growth factor receptor 1 is a novel target of methylation by SMYD3.
Topics: Cell Line; Cell Line, Tumor; Cell Proliferation; DNA Methylation; Gene Expression Regulation, Neoplastic; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Humans; Lysine; Methylation; Models, Biological; Phosphorylation; Plasmids; Protein Methyltransferases; Serine; Vascular Endothelial Growth Factor Receptor-1 | 2007 |
Localized H3K36 methylation states define histone H4K16 acetylation during transcriptional elongation in Drosophila.
Topics: Acetylation; Animals; Drosophila melanogaster; Drosophila Proteins; Gene Expression Regulation; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Nuclear Proteins; Oligonucleotide Array Sequence Analysis; Promoter Regions, Genetic; Protein Processing, Post-Translational; RNA Interference; Transcription, Genetic | 2007 |
Transitional B cells lose their ability to receptor edit but retain their potential for positive and negative selection.
Topics: Acetylation; Animals; Antibodies; Antigen-Antibody Reactions; Apoptosis; B-Lymphocytes; Cell Differentiation; DNA-Binding Proteins; Histones; Homeodomain Proteins; Immunoglobulin Heavy Chains; Lysine; Methylation; Mice; Mice, Knockout; Mice, Transgenic; Receptors, Antigen, B-Cell; Sensitivity and Specificity | 2007 |
L3MBTL1 recognition of mono- and dimethylated histones.
Topics: Amino Acid Sequence; Calorimetry; Chromosomal Proteins, Non-Histone; Histones; Lysine; Methylation; Models, Molecular; Molecular Sequence Data; Neoplasm Proteins; Protein Binding; Repressor Proteins; Sequence Homology, Amino Acid; Tumor Suppressor Proteins | 2007 |
5' flanking region of var genes nucleate histone modification patterns linked to phenotypic inheritance of virulence traits in malaria parasites.
Topics: 5' Flanking Region; Animals; Base Sequence; Blotting, Western; Chromatin Immunoprecipitation; Gene Expression Regulation; Histones; Humans; Lysine; Malaria; Methylation; Molecular Sequence Data; Plasmodium falciparum; Polymerase Chain Reaction; Protozoan Proteins; Transcription, Genetic; Virulence | 2007 |
RAG2 PHD finger couples histone H3 lysine 4 trimethylation with V(D)J recombination.
Topics: Amino Acid Motifs; Animals; Binding Sites; DNA-Binding Proteins; Gene Rearrangement, B-Lymphocyte; Histones; Homeodomain Proteins; Humans; Immunologic Deficiency Syndromes; Lysine; Methylation; Mice; Models, Molecular; Protein Binding; Recombination, Genetic; Structure-Activity Relationship; Substrate Specificity; Tryptophan; VDJ Recombinases | 2007 |
In vivo analysis of Drosophila SU(Z)12 function.
Topics: Animals; Animals, Genetically Modified; Chromosomal Proteins, Non-Histone; Chromosomes; Drosophila melanogaster; Drosophila Proteins; Female; Green Fluorescent Proteins; Histone-Lysine N-Methyltransferase; Histones; Immunohistochemistry; Lysine; Male; Methylation; Mutation; Polycomb Repressive Complex 1; Polycomb Repressive Complex 2; Polycomb-Group Proteins; Protein Binding; Repressor Proteins | 2008 |
Recognition of trimethylated histone H3 lysine 4 facilitates the recruitment of transcription postinitiation factors and pre-mRNA splicing.
Topics: Chromatin; DNA Helicases; DNA-Binding Proteins; HeLa Cells; Histones; Humans; Lysine; Methylation; Models, Genetic; Peptides; Protein Binding; Ribonucleoprotein, U2 Small Nuclear; RNA Precursors; RNA Splicing; Spliceosomes; Transcription Factors; Transcription, Genetic | 2007 |
Structural basis for lower lysine methylation state-specific readout by MBT repeats of L3MBTL1 and an engineered PHD finger.
Topics: Amino Acid Sequence; Antigens, Nuclear; Chromosomal Proteins, Non-Histone; Crystallography, X-Ray; DNA Mutational Analysis; Glutamic Acid; Histones; Humans; Kinetics; Lysine; Methylation; Models, Molecular; Molecular Sequence Data; Mutant Proteins; Neoplasm Proteins; Nerve Tissue Proteins; Peptides; Protein Engineering; Protein Structure, Tertiary; Repetitive Sequences, Amino Acid; Repressor Proteins; Structure-Activity Relationship; Transcription Factors; Tumor Suppressor Proteins; Tyrosine | 2007 |
JARID1B is a histone H3 lysine 4 demethylase up-regulated in prostate cancer.
Topics: Cell Line, Tumor; Computational Biology; Dioxygenases; DNA-Binding Proteins; Gene Expression; Histones; Humans; Jumonji Domain-Containing Histone Demethylases; Lysine; Male; Methylation; Nuclear Proteins; Phylogeny; Prostatic Neoplasms; Protein Structure, Tertiary; Repressor Proteins; Up-Regulation | 2007 |
Di- and tri- but not monomethylation on histone H3 lysine 36 marks active transcription of genes involved in flowering time regulation and other processes in Arabidopsis thaliana.
Topics: Arabidopsis; Arabidopsis Proteins; Cell Nucleus; Chromatin Immunoprecipitation; Down-Regulation; Flowers; Gene Expression Profiling; Gene Expression Regulation, Plant; Genes, Plant; Histone-Lysine N-Methyltransferase; Histones; Lysine; MADS Domain Proteins; Methylation; Mutation; Phenotype; Phylogeny; Protein Transport; Time Factors; Transcription, Genetic; Up-Regulation | 2008 |
Dynamic histone H3 methylation during gene induction: HYPB/Setd2 mediates all H3K36 trimethylation.
Topics: Animals; Blotting, Northern; Cell Line; Drosophila Proteins; Epidermal Growth Factor; Gene Expression Regulation; Histones; Immunoblotting; Immunoprecipitation; Lysine; Methylation; Mice; Mice, Inbred C3H; Proto-Oncogene Proteins c-fos; Proto-Oncogene Proteins c-jun; Reverse Transcriptase Polymerase Chain Reaction; RNA, Small Interfering; Transcription, Genetic; Transcriptional Activation; Transfection | 2008 |
PR-Set7-dependent lysine methylation ensures genome replication and stability through S phase.
Topics: Ataxia Telangiectasia Mutated Proteins; Cell Cycle Proteins; Cell Line, Tumor; DNA Damage; DNA Repair; DNA Replication; DNA-Binding Proteins; Down-Regulation; Genomic Instability; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; RNA, Small Interfering; S Phase; Tumor Suppressor Proteins | 2007 |
Interplay of chromatin modifiers on a short basic patch of histone H4 tail defines the boundary of telomeric heterochromatin.
Topics: Acetylation; Blotting, Western; Chromatin; Chromatin Immunoprecipitation; Fungal Proteins; Heterochromatin; Histones; Lysine; Methylation; Nuclear Proteins; Nucleosomes; Protein Binding; Telomere; Yeasts | 2007 |
CENP-B controls centromere formation depending on the chromatin context.
Topics: Animals; Autoantigens; Cell Line, Transformed; Cell Line, Tumor; Centromere; Centromere Protein A; Centromere Protein B; Chromatin; Chromatin Assembly and Disassembly; Chromatin Immunoprecipitation; Chromosomal Proteins, Non-Histone; Chromosomes, Artificial, Human; Chromosomes, Artificial, Mammalian; CpG Islands; DNA Methylation; DNA, Satellite; Embryo, Mammalian; Fibroblasts; Heterochromatin; Histones; Humans; In Situ Hybridization, Fluorescence; Lysine; Methylation; Mice; Mice, Knockout; Nucleic Acid Conformation; Protein Binding; Time Factors; Transfection | 2007 |
Deubiquitylation of histone H2A activates transcriptional initiation via trans-histone cross-talk with H3K4 di- and trimethylation.
Topics: Animals; Chromatin; Chromatin Immunoprecipitation; Histone Deacetylases; Histones; Lysine; Methylation; Mice; Models, Biological; Models, Genetic; Transcription Initiation Site; Transcriptional Activation; Ubiquitin; Ubiquitin Thiolesterase; Ubiquitination | 2008 |
Developmental information but not promoter activity controls the methylation state of histone H3 lysine 4 on two photosynthetic genes in maize.
Topics: Chromatin Immunoprecipitation; Epigenesis, Genetic; Genes, Plant; Histones; Lysine; Methylation; Photosynthesis; Plant Leaves; Polymerase Chain Reaction; Promoter Regions, Genetic; Zea mays | 2008 |
Histone H3 tails containing dimethylated lysine and adjacent phosphorylated serine modifications adopt a specific conformation during mitosis and meiosis.
Topics: Animals; Bisbenzimidazole; Female; Fluorescent Dyes; HeLa Cells; Histones; Humans; Hydrogen Bonding; Lysine; Male; Meiosis; Methylation; Mice; Mice, Inbred Strains; Mitosis; NIH 3T3 Cells; Oocytes; Phosphorylation; Protein Conformation; Serine; Testis | 2008 |
DNA oxidation as triggered by H3K9me2 demethylation drives estrogen-induced gene expression.
Topics: Cell Line, Tumor; Cells, Cultured; Chromatin; DNA; DNA Damage; DNA Glycosylases; DNA Repair; DNA Topoisomerases, Type II; DNA-Binding Proteins; Enhancer Elements, Genetic; Estradiol; Estrogen Receptor alpha; Gene Expression Regulation; Genes, bcl-2; Guanine; Histone Demethylases; Histones; Humans; Hydrogen Peroxide; Lysine; Methylation; Nucleic Acid Conformation; Oxidation-Reduction; Oxidoreductases, N-Demethylating; Promoter Regions, Genetic; RNA Polymerase II; Transcription, Genetic | 2008 |
A conserved SET domain methyltransferase, Set11, modifies ribosomal protein Rpl12 in fission yeast.
Topics: Amino Acid Sequence; HeLa Cells; Humans; Lysine; Mass Spectrometry; Methylation; Methyltransferases; Models, Biological; Molecular Sequence Data; Protein Processing, Post-Translational; Protein Structure, Tertiary; Recombinant Proteins; Ribosomal Proteins; Ribosomes; Schizosaccharomyces; Schizosaccharomyces pombe Proteins; Sequence Homology, Amino Acid | 2008 |
Differential loss of histone H3 isoforms mono-, di- and tri-methylated at lysine 4 during X-inactivation in female embryonic stem cells.
Topics: Animals; Cell Differentiation; Dosage Compensation, Genetic; Embryonic Stem Cells; Epigenesis, Genetic; Female; Fluorescent Antibody Technique; Histones; Immunoprecipitation; In Situ Hybridization, Fluorescence; Lysine; Metaphase; Methylation; Mice; X Chromosome Inactivation | 2008 |
The organization of histone H3 modifications as revealed by a panel of specific monoclonal antibodies.
Topics: Acetylation; Animals; Antibodies, Monoclonal; Antibody Specificity; Cellular Senescence; Chromatin Immunoprecipitation; Fibroblasts; Fluorescent Antibody Technique; Histones; Humans; Immunoblotting; Lysine; Methylation; Mice; Nucleosomes | 2008 |
Histone methylation patterns are cell-type specific in human monocytes and lymphocytes and well maintained at core genes.
Topics: Adult; Aged; Biomarkers; CpG Islands; Female; Gene Expression Profiling; Genetic Markers; Histones; Humans; Lymphocytes; Lysine; Male; Methylation; Middle Aged; Monocytes; Oligonucleotide Array Sequence Analysis | 2008 |
The Arabidopsis SDG4 contributes to the regulation of pollen tube growth by methylation of histone H3 lysines 4 and 36 in mature pollen.
Topics: Amino Acid Sequence; Arabidopsis; Arabidopsis Proteins; Base Sequence; Cell Line; DNA Primers; DNA, Plant; Genes, Plant; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Molecular Sequence Data; Mutation; Nicotiana; Oligonucleotide Array Sequence Analysis; Plants, Genetically Modified; Pollen; Pollen Tube; Sequence Homology, Amino Acid | 2008 |
Beyond histone methyl-lysine binding: how malignant brain tumor (MBT) protein L3MBTL1 impacts chromatin structure.
Topics: Animals; Chromatin; Chromosomal Proteins, Non-Histone; Gene Expression Regulation, Neoplastic; Histones; Humans; Lysine; Methylation; Mitosis; Neoplasm Proteins; Protein Binding; Protein Structure, Tertiary; Repressor Proteins; Tumor Suppressor Proteins | 2008 |
Trypanosome H2Bv replaces H2B in nucleosomes enriched for H3 K4 and K76 trimethylation.
Topics: Amino Acid Sequence; Animals; Histones; Lysine; Methylation; Molecular Sequence Data; Nucleosomes; Sequence Alignment; Trypanosoma brucei brucei | 2008 |
The ankyrin repeats of G9a and GLP histone methyltransferases are mono- and dimethyllysine binding modules.
Topics: Animals; Ankyrin Repeat; Chlorocebus aethiops; COS Cells; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Methyltransferases; Mice; Mutant Proteins; Mutation; Peptides; Protein Binding | 2008 |
Methylation of p53 by Set7/9 mediates p53 acetylation and activity in vivo.
Topics: Acetylation; Acetyltransferases; Animals; Cell Cycle; Cell Line; Cell Line, Transformed; Cell Transformation, Viral; DNA Damage; Embryo, Mammalian; Fibroblasts; Gene Dosage; Glutathione Transferase; HCT116 Cells; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Humans; Kidney; Lysine; Methylation; Mice; Mice, Inbred C57BL; Mice, Knockout; Mutation; Protein Methyltransferases; Tumor Suppressor Protein p53 | 2008 |
Ezh2 requires PHF1 to efficiently catalyze H3 lysine 27 trimethylation in vivo.
Topics: Catalysis; Cell Line; Cell Proliferation; Cell Shape; DNA-Binding Proteins; Enhancer of Zeste Homolog 2 Protein; Homeodomain Proteins; Humans; Lysine; Methylation; Polycomb Repressive Complex 2; Polycomb-Group Proteins; Promoter Regions, Genetic; Protein Binding; Repressor Proteins; RNA, Small Interfering; Transcription Factors; Transcription, Genetic | 2008 |
DOT1L/KMT4 recruitment and H3K79 methylation are ubiquitously coupled with gene transcription in mammalian cells.
Topics: Adipocytes; Animals; CD36 Antigens; Cell Differentiation; Cells, Cultured; Chromatin; Chromatin Immunoprecipitation; GATA1 Transcription Factor; Globins; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Methyltransferases; Mice; Mice, Inbred C57BL; PPAR gamma; Sodium Dodecyl Sulfate; Transcription, Genetic | 2008 |
Serological reactivity and biochemical characterization of methylated and unmethylated forms of a recombinant protein fragment derived from outer membrane protein B of Rickettsia typhi.
Topics: Antibodies, Bacterial; Antibody Specificity; Bacterial Outer Membrane Proteins; Chromatography, Liquid; Cloning, Molecular; Enzyme-Linked Immunosorbent Assay; Humans; Lysine; Mass Spectrometry; Methylation; Peptide Fragments; Protein Folding; Recombinant Proteins; Rickettsia typhi | 2008 |
Epigenetic marking prepares the human HOXA cluster for activation during differentiation of pluripotent cells.
Topics: Acetylation; Animals; Carcinoma, Embryonal; Cell Differentiation; Cell Line; Epigenesis, Genetic; Gene Expression Regulation, Developmental; Genome, Human; Histones; Homeodomain Proteins; Humans; Lysine; Methylation; Mice; Pluripotent Stem Cells | 2008 |
Preferential dimethylation of histone H4 lysine 20 by Suv4-20.
Topics: Animals; Chromobox Protein Homolog 5; Chromosomal Proteins, Non-Histone; DNA (Cytosine-5-)-Methyltransferases; DNA Damage; Drosophila melanogaster; Drosophila Proteins; HeLa Cells; Histone-Lysine N-Methyltransferase; Histones; Humans; Intracellular Signaling Peptides and Proteins; Lysine; Mass Spectrometry; Methylation; RNA Interference; RNA, Small Interfering; Tumor Suppressor p53-Binding Protein 1 | 2008 |
Histone lysine methyltransferases and demethylases in Plasmodium falciparum.
Topics: Amino Acid Sequence; Animals; Cells, Cultured; Erythrocytes; Gene Expression Regulation, Developmental; Genes, Protozoan; Histone-Lysine N-Methyltransferase; Humans; Lysine; Methylation; Molecular Sequence Data; Phylogeny; Plasmodium falciparum; Protozoan Proteins; Reverse Transcriptase Polymerase Chain Reaction; Sequence Alignment; Substrate Specificity | 2008 |
Class-specific regulation of pro-inflammatory genes by MyD88 pathways and IkappaBzeta.
Topics: Adaptor Proteins, Signal Transducing; Animals; Cells, Cultured; Chromatin Assembly and Disassembly; DNA Helicases; Gene Expression Regulation; Histones; Inflammation Mediators; Lysine; Macrophages; Methylation; Mice; Models, Genetic; Myeloid Differentiation Factor 88; Nuclear Proteins; Nucleosomes; Promoter Regions, Genetic; Transcription Factors | 2008 |
Ankyrin for methylated lysines.
Topics: Animals; Ankyrin Repeat; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Mice | 2008 |
X-chromosome inactivation and epigenetic fluidity in human embryonic stem cells.
Topics: Cell Differentiation; Cell Line; Cell Nucleus; Embryonic Stem Cells; Epigenesis, Genetic; Histones; Humans; In Situ Hybridization, Fluorescence; Karyotyping; Lysine; Methylation; Reverse Transcriptase Polymerase Chain Reaction; RNA, Long Noncoding; RNA, Untranslated; X Chromosome Inactivation | 2008 |
Transcription-coupled methylation of histone H3 at lysine 36 regulates dosage compensation by enhancing recruitment of the MSL complex in Drosophila melanogaster.
Topics: Animals; Binding Sites; Cell Line; Chromatin Immunoprecipitation; Dosage Compensation, Genetic; Drosophila melanogaster; Drosophila Proteins; Female; Histones; Lysine; Male; Methylation; Models, Biological; Multiprotein Complexes; RNA Interference; Sex Determination Processes; Transcription Factors; Transcription, Genetic; X Chromosome | 2008 |
Human ES cell profiling broadens the reach of bivalent domains.
Topics: Animals; Embryonic Stem Cells; Epigenesis, Genetic; Gene Expression Profiling; Genome, Human; Histones; Humans; Lysine; Methylation; Mice; Promoter Regions, Genetic; Transcription, Genetic | 2007 |
Whole-genome mapping of histone H3 Lys4 and 27 trimethylations reveals distinct genomic compartments in human embryonic stem cells.
Topics: Animals; Cell Differentiation; Conserved Sequence; DNA-Binding Proteins; DNA, Intergenic; Embryonic Stem Cells; Gene Expression Profiling; Genome, Human; Histones; Humans; Lysine; Methylation; Mice; Proteasome Endopeptidase Complex; Protein Transport; Transcription, Genetic; Up-Regulation; Vertebrates | 2007 |
Whole-genome analysis of histone H3 lysine 4 and lysine 27 methylation in human embryonic stem cells.
Topics: Cell Differentiation; Cell Lineage; Embryonic Stem Cells; Gene Expression Regulation; Genome, Human; Histones; Humans; Lysine; Methylation; Promoter Regions, Genetic; Protein Transport | 2007 |
Activating signal cointegrator-2 is an essential adaptor to recruit histone H3 lysine 4 methyltransferases MLL3 and MLL4 to the liver X receptors.
Topics: Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Animals; Cells, Cultured; DNA-Binding Proteins; Embryo, Mammalian; Histone-Lysine N-Methyltransferase; Histones; Humans; Intracellular Signaling Peptides and Proteins; Liver X Receptors; Lysine; Methylation; Mice; Mice, Knockout; Models, Biological; Nuclear Receptor Coactivators; Orphan Nuclear Receptors; Protein Binding; Proto-Oncogene Proteins; Receptors, Cytoplasmic and Nuclear; Transcriptional Activation | 2008 |
ARABIDOPSIS TRITHORAX1 dynamically regulates FLOWERING LOCUS C activation via histone 3 lysine 4 trimethylation.
Topics: Arabidopsis Proteins; Chromatin; Chromatin Immunoprecipitation; Gene Expression Regulation, Plant; Histone-Lysine N-Methyltransferase; Histones; In Situ Hybridization; Lysine; MADS Domain Proteins; Methylation; Models, Biological; Plants, Genetically Modified; Protein Binding; Reverse Transcriptase Polymerase Chain Reaction; Transcription Factors | 2008 |
Enzymatic mechanism and product specificity of SET-domain protein lysine methyltransferases.
Topics: Chromatin; Histone-Lysine N-Methyltransferase; Lysine; Methylation; Models, Molecular; Quantum Theory; S-Adenosylhomocysteine; S-Adenosylmethionine | 2008 |
Polycomb repressive complex 2 is dispensable for maintenance of embryonic stem cell pluripotency.
Topics: Animals; Chimera; Embryonic Stem Cells; Immunohistochemistry; Jumonji Domain-Containing Histone Demethylases; Lysine; Methylation; Mice; Mice, Knockout; Oligonucleotide Array Sequence Analysis; Oxidoreductases, N-Demethylating; Pluripotent Stem Cells; Polycomb Repressive Complex 2; Polycomb-Group Proteins; Repressor Proteins; Reverse Transcriptase Polymerase Chain Reaction | 2008 |
Histone H4 lysine 20 monomethylation promotes transcriptional repression by L3MBTL1.
Topics: Binding Sites; Cell Cycle; Chromatin; Chromosomal Proteins, Non-Histone; Gene Expression Regulation; Histone-Lysine N-Methyltransferase; Histones; Humans; K562 Cells; Lysine; Methylation; Neoplasm Proteins; Protein Binding; Repressor Proteins; Transcription, Genetic; Tumor Suppressor Proteins | 2008 |
Post-translational modifications of Desulfovibrio vulgaris Hildenborough sulfate reduction pathway proteins.
Topics: Acetylation; Amino Acid Sequence; Bacterial Proteins; Chromatography, Liquid; Desulfovibrio desulfuricans; Desulfovibrio vulgaris; Hydrogensulfite Reductase; Lysine; Metabolic Networks and Pathways; Methylation; Models, Molecular; Molecular Sequence Data; Oxidation-Reduction; Oxidoreductases Acting on Sulfur Group Donors; Protein Conformation; Protein Processing, Post-Translational; Ribosomal Proteins; Sequence Homology, Amino Acid; Sulfate Adenylyltransferase; Sulfates; Tandem Mass Spectrometry | 2008 |
Changes on histone H3 modifications on the GLUT5 gene and its expression in Caco-2 cells co-treated with a p44/42 MAPK inhibitor and glucocorticoid hormone.
Topics: Acetylation; Caco-2 Cells; Dexamethasone; Flavonoids; Gene Expression; Gene Expression Regulation; Glucocorticoids; Glucose Transporter Type 5; Histones; Humans; Lysine; Methylation; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Protein Kinase Inhibitors | 2008 |
Chemically ubiquitylated histone H2B stimulates hDot1L-mediated intranucleosomal methylation.
Topics: Allosteric Regulation; Animals; Catalytic Domain; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Methyltransferases; Nucleosomes; Ubiquitin; Xenopus | 2008 |
Regulation of estrogen receptor alpha by the SET7 lysine methyltransferase.
Topics: Amino Acid Sequence; Breast Neoplasms; Cell Line; Crystallography, X-Ray; Estrogen Receptor alpha; Estrogens; Female; Gene Expression Regulation; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Humans; Lysine; Methylation; Models, Molecular; Molecular Sequence Data; Mutation; Peptides; Protein Conformation; Protein Methyltransferases; Sequence Alignment | 2008 |
Differential H3K4 methylation identifies developmentally poised hematopoietic genes.
Topics: Animals; Binding Sites; Bone Marrow Cells; Cell Differentiation; Cell Line; Cell Lineage; CpG Islands; Embryonic Stem Cells; Gene Expression Regulation, Developmental; Genes, Developmental; Genome; Hematopoietic System; Histones; Humans; Lysine; Methylation; Mice; Models, Genetic; Promoter Regions, Genetic; Transcription Factors; Transcription Initiation Site; Transcription, Genetic | 2008 |
A genomic analysis of RNA polymerase II modification and chromatin architecture related to 3' end RNA polyadenylation.
Topics: Cell Line; Chromatin; Chromatin Immunoprecipitation; Genomics; HeLa Cells; Histones; Humans; Lysine; Methylation; Oligonucleotide Array Sequence Analysis; Polyadenylation; RNA Polymerase II; RNA, Messenger; Transcription, Genetic | 2008 |
A gateway to study protein lysine methylation.
Topics: Amino Acid Motifs; Binding Sites; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Protein Array Analysis; Protein Methyltransferases; Substrate Specificity | 2008 |
Chemical answers to epigenetic crosstalk.
Topics: Epigenesis, Genetic; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Methyltransferases; Models, Biological; Mutation; Protein Processing, Post-Translational; Transcription, Genetic; Ubiquitin | 2008 |
Lysine methylation of HIV-1 Tat regulates transcriptional activity of the viral LTR.
Topics: Cell Line; Genes, Reporter; Histone-Lysine N-Methyltransferase; HIV Long Terminal Repeat; HIV-1; Humans; Lysine; Methylation; Protein Binding; Protein Methyltransferases; Protein Processing, Post-Translational; Protein Structure, Tertiary; RNA, Small Interfering; tat Gene Products, Human Immunodeficiency Virus; Transcription, Genetic; Transcriptional Activation; Virus Activation | 2008 |
Decoding of methylated histone H3 tail by the Pygo-BCL9 Wnt signaling complex.
Topics: Adaptor Proteins, Signal Transducing; Amino Acid Sequence; Animals; Binding Sites; Crystallography, X-Ray; Drosophila melanogaster; Drosophila Proteins; Histones; Humans; Intracellular Signaling Peptides and Proteins; Lysine; Methylation; Models, Molecular; Molecular Sequence Data; Multiprotein Complexes; Neoplasm Proteins; Peptides; Protein Binding; Protein Conformation; Recombinant Fusion Proteins; Sequence Alignment; Signal Transduction; Transcription Factors; Wnt Proteins | 2008 |
The PHD domain of the sea urchin RAG2 homolog, SpRAG2L, recognizes dimethylated lysine 4 in histone H3 tails.
Topics: Amino Acid Sequence; Animals; Cell Line; Conserved Sequence; DNA-Binding Proteins; Histones; Humans; Lysine; Methylation; Mice; Molecular Sequence Data; Mutation; Protein Binding; Sea Urchins; Sequence Alignment | 2008 |
Developmental regulation of histone H3 methylation at lysine 4 in the porcine ovary.
Topics: Animals; Epigenesis, Genetic; Female; Fluorescent Antibody Technique; Granulosa Cells; Histones; Lysine; Methylation; Oogenesis; Ovarian Follicle; Ovary; Pregnancy; Protein Processing, Post-Translational; Sus scrofa | 2008 |
Product specificity and mechanism of protein lysine methyltransferases: insights from the histone lysine methyltransferase SET8.
Topics: Catalysis; Histone-Lysine N-Methyltransferase; Histones; Humans; Kinetics; Lysine; Methylation; Models, Chemical; Models, Molecular; Molecular Dynamics Simulation; Molecular Structure; Protein Binding; Protein Structure, Tertiary; Quantum Theory; S-Adenosylhomocysteine; S-Adenosylmethionine; Static Electricity; Substrate Specificity | 2008 |
ING2 recruits histone methyltransferase activity with methylation site specificity distinct from histone H3 lysines 4 and 9.
Topics: Animals; Cell Line; Chlorocebus aethiops; Gene Deletion; Gene Silencing; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Homeodomain Proteins; Humans; Lysine; Methylation; Mice; Mutation; Protein Methyltransferases; Receptors, Cytoplasmic and Nuclear; Substrate Specificity; Transcription, Genetic; Tumor Suppressor Protein p53; Tumor Suppressor Proteins | 2008 |
Simplifying a complex code.
Topics: Epigenesis, Genetic; Histones; Lysine; Methylation | 2008 |
Histone H3K4me3 binding is required for the DNA repair and apoptotic activities of ING1 tumor suppressor.
Topics: Apoptosis; Crystallography, X-Ray; DNA Repair; Histones; Humans; Inhibitor of Growth Protein 1; Intracellular Signaling Peptides and Proteins; Lysine; Methylation; Models, Molecular; Molecular Sequence Data; Mutation; Neoplasms; Nuclear Proteins; Peptides; Protein Array Analysis; Protein Binding; Protein Structure, Tertiary; Tumor Suppressor Proteins | 2008 |
The CHD3 remodeler PICKLE promotes trimethylation of histone H3 lysine 27.
Topics: Arabidopsis; Arabidopsis Proteins; DNA Helicases; Gene Expression Regulation, Plant; Germination; Histone Deacetylases; Histones; Lysine; Methylation; Miconazole; Seedlings; Seeds | 2008 |
Roles for Ctk1 and Spt6 in regulating the different methylation states of histone H3 lysine 36.
Topics: Acetylation; Chromatin; Gene Expression Regulation, Fungal; Histone Chaperones; Histones; Lysine; Methylation; Nuclear Proteins; Promoter Regions, Genetic; Protein Kinases; Protein Structure, Tertiary; Recombinant Proteins; Repressor Proteins; RNA Polymerase II; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Transcriptional Elongation Factors | 2008 |
Epigenetic histone H3 lysine 9 methylation in metabolic memory and inflammatory phenotype of vascular smooth muscle cells in diabetes.
Topics: Animals; Chromobox Protein Homolog 5; Chromosomal Proteins, Non-Histone; Diabetes Mellitus; Epigenesis, Genetic; Glucose; Histones; Humans; Immunologic Memory; Inflammation; Lysine; Methylation; Methyltransferases; Mice; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Phenotype; Promoter Regions, Genetic; Protein Binding; Repressor Proteins; Tumor Necrosis Factor-alpha | 2008 |
Just the FACTs: histone H2B ubiquitylation and nucleosome dynamics.
Topics: Chromatin; Histones; Lysine; Methylation; Nucleosomes; Protein Binding; Saccharomyces cerevisiae; Transcription, Genetic; Ubiquitination | 2008 |
H2B ubiquitylation plays a role in nucleosome dynamics during transcription elongation.
Topics: Cell Cycle Proteins; Chromatin; Galactokinase; Histones; Kinetics; Lysine; Methylation; Nucleosomes; Protein Binding; RNA Polymerase II; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Transcription Factors; Transcription, Genetic; Transcriptional Elongation Factors; Ubiquitination | 2008 |
Site-specific incorporation of methyl- and acetyl-lysine analogues into recombinant proteins.
Topics: Acetylation; Animals; Aurora Kinases; Codon, Terminator; Histones; Lysine; Methanococcus; Methylation; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Recombinant Proteins; RNA, Transfer, Amino Acyl; Selenocysteine; Tyrosine-tRNA Ligase; Xenopus | 2008 |
siRNA-mediated heterochromatin establishment requires HP1 and is associated with antisense transcription.
Topics: Adenosine Triphosphatases; Catalysis; Centromere; Chromobox Protein Homolog 5; Chromosomal Proteins, Non-Histone; DNA, Antisense; Gene Silencing; Heterochromatin; Histones; Inheritance Patterns; Lysine; Methylation; Models, Genetic; Nucleic Acid Conformation; RNA-Dependent RNA Polymerase; RNA, Small Interfering; Schizosaccharomyces; Schizosaccharomyces pombe Proteins; Transcription, Genetic; Transgenes | 2008 |
Antagonism between DNA and H3K27 methylation at the imprinted Rasgrf1 locus.
Topics: Alleles; Animals; Cells, Cultured; DNA Methylation; Female; Genomic Imprinting; Histones; Lysine; Male; Methylation; Mice; Mice, Inbred Strains; Models, Genetic; ras-GRF1; Species Specificity | 2008 |
Role of the lysine-specific demethylase 1 in the proinflammatory phenotype of vascular smooth muscle cells of diabetic mice.
Topics: Animals; Diabetes Mellitus, Type 2; Histone Demethylases; Histones; Humans; Inflammation Mediators; Lysine; Male; Methylation; Mice; Mice, Knockout; Mice, Mutant Strains; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Oxidoreductases, N-Demethylating; Phenotype | 2008 |
Role of hMOF-dependent histone H4 lysine 16 acetylation in the maintenance of TMS1/ASC gene activity.
Topics: Acetylation; Antigens, CD; Apoptosis; Blotting, Western; Breast Neoplasms; Cadherins; CARD Signaling Adaptor Proteins; Cells, Cultured; Chromatin Immunoprecipitation; CpG Islands; Cytoskeletal Proteins; Epigenesis, Genetic; Estrogen Receptor alpha; Fibroblasts; Gene Expression Regulation, Neoplastic; Histone Acetyltransferases; Histones; Humans; Kidney; Lysine; Methylation; Nucleosomes; Polymerase Chain Reaction; RNA, Small Interfering | 2008 |
Testis-specific histone variants H2AL1/2 rapidly disappear from paternal heterochromatin after fertilization.
Topics: Acetylation; Animals; Female; Fertilization in Vitro; Genetic Variation; Heterochromatin; Histones; Lysine; Male; Methylation; Mice; Sperm Injections, Intracytoplasmic; Sperm-Ovum Interactions; Spermatozoa; Testis; Zygote | 2008 |
The malignant brain tumor repeats of human SCML2 bind to peptides containing monomethylated lysine.
Topics: Binding Sites; DNA-Binding Proteins; Epigenesis, Genetic; Histones; Humans; In Vitro Techniques; Kinetics; Ligands; Lysine; Methylation; Models, Molecular; Nuclear Magnetic Resonance, Biomolecular; Peptides; Polycomb-Group Proteins; Protein Binding; Protein Conformation; Repetitive Sequences, Amino Acid; Transcription Factors | 2008 |
Genome-wide analysis of the H3K4 histone demethylase RBP2 reveals a transcriptional program controlling differentiation.
Topics: Binding Sites; Cell Differentiation; Gene Expression Profiling; Gene Expression Regulation; Genome, Human; Genomics; Histones; Humans; Intracellular Signaling Peptides and Proteins; Lysine; Methylation; Mitochondria; Models, Biological; Nucleosomes; Oxidoreductases, N-Demethylating; Promoter Regions, Genetic; Protein Binding; Repressor Proteins; Retinoblastoma-Binding Protein 2; Sequence Analysis, DNA; Transcription Factors; Transcription, Genetic; Tumor Suppressor Proteins | 2008 |
BAT3 and SET1A form a complex with CTCFL/BORIS to modulate H3K4 histone dimethylation and gene expression.
Topics: Animals; BRCA1 Protein; Chlorocebus aethiops; COS Cells; DNA-Binding Proteins; Gene Expression Regulation, Neoplastic; HCT116 Cells; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Molecular Chaperones; Nuclear Proteins; Promoter Regions, Genetic; Protein Binding; Proteins; Proto-Oncogene Proteins c-myc; RNA, Long Noncoding; RNA, Small Interfering; RNA, Untranslated; Transcription Factors | 2008 |
Histone H3 modifications associated with differentiation and long-term culture of mesenchymal adipose stem cells.
Topics: Acetylation; Adipogenesis; Adipose Tissue; Adult; Cell Culture Techniques; Cell Differentiation; Cell Lineage; Cells, Cultured; Cellular Senescence; DNA-Binding Proteins; Enhancer of Zeste Homolog 2 Protein; Female; Gene Expression Regulation; Histones; Humans; Keratinocytes; Lysine; Mesenchymal Stem Cells; Methylation; Nuclear Proteins; Organ Specificity; Polycomb Repressive Complex 1; Polycomb Repressive Complex 2; Promoter Regions, Genetic; Protein Processing, Post-Translational; Proto-Oncogene Proteins; Repressor Proteins; Time Factors; Transcription Factors; Transcription, Genetic | 2009 |
Genome-wide association of histone H3 lysine nine methylation with CHG DNA methylation in Arabidopsis thaliana.
Topics: Arabidopsis; Arabidopsis Proteins; Chromatin; Chromatin Immunoprecipitation; DNA Methylation; DNA Transposable Elements; Epigenesis, Genetic; Genes, Plant; Genome-Wide Association Study; Genome, Plant; Heterochromatin; Histones; Lysine; Methylation; RNA, Small Interfering; Transcription, Genetic | 2008 |
Alterations of lysine modifications on the histone H3 N-tail under drought stress conditions in Arabidopsis thaliana.
Topics: Acetylation; Arabidopsis; Arabidopsis Proteins; Chromatin Immunoprecipitation; Disasters; Gene Expression Profiling; Gene Expression Regulation, Plant; Histones; Lysine; Methylation; Nucleosomes; Open Reading Frames; Promoter Regions, Genetic; Protein Processing, Post-Translational; Reverse Transcriptase Polymerase Chain Reaction; RNA Polymerase II; RNA, Messenger; RNA, Plant; Transcriptional Activation | 2008 |
Modulation of retinoic acid receptor alpha activity by lysine methylation in the DNA binding domain.
Topics: Amino Acid Sequence; Animals; Binding Sites; Chlorocebus aethiops; COS Cells; DNA-Binding Proteins; Histone-Lysine N-Methyltransferase; Lysine; Methylation; Mice; Molecular Sequence Data; Protein Structure, Tertiary; Receptors, Retinoic Acid; Recombinant Fusion Proteins; Retinoic Acid Receptor alpha | 2008 |
Polycomb gene expression and histone H3 lysine 27 trimethylation changes during bovine preimplantation development.
Topics: Animals; Blastocyst; Cattle; Embryonic Development; Fertilization in Vitro; Gene Expression; Gene Expression Regulation, Developmental; Histones; Immunoblotting; Lysine; Methylation; Microscopy, Confocal; Oocytes; Polycomb-Group Proteins; Repressor Proteins; Reverse Transcriptase Polymerase Chain Reaction | 2008 |
Genome-wide relationship between histone H3 lysine 4 mono- and tri-methylation and transcription factor binding.
Topics: Animals; Base Sequence; Binding Sites; Cell Line, Transformed; Chromatin Immunoprecipitation; Female; Gene Expression Regulation; Genome, Human; HeLa Cells; Hepatocyte Nuclear Factor 3-beta; Histones; Humans; Interferon-gamma; Lysine; Methylation; Mice; Mice, Inbred C57BL; Protein Binding; Regulatory Sequences, Nucleic Acid; Sequence Homology, Nucleic Acid; STAT1 Transcription Factor; Transcription Factors | 2008 |
The effect of H3K79 dimethylation and H4K20 trimethylation on nucleosome and chromatin structure.
Topics: Chromatin; Crystallography, X-Ray; Histones; Lysine; Methylation; Models, Molecular; Nucleosomes; Protein Structure, Tertiary | 2008 |
Age-related difference of site-specific histone modifications in rat liver.
Topics: Acetylation; Age Factors; Aging; Amino Acid Sequence; Animals; Chromatin Assembly and Disassembly; Epigenesis, Genetic; Histones; Liver; Lysine; Male; Methylation; Molecular Sequence Data; Phosphorylation; Protein Processing, Post-Translational; Rats; Rats, Inbred F344; Serine | 2009 |
Detection of protein-ligand interactions by NMR using reductive methylation of lysine residues.
Topics: Calmodulin; Humans; Ligands; Lysine; Methylation; Nuclear Magnetic Resonance, Biomolecular | 2008 |
Di-methyl H4 lysine 20 targets the checkpoint protein Crb2 to sites of DNA damage.
Topics: Amino Acid Motifs; Cell Cycle Proteins; Chromatin; DNA Damage; DNA, Fungal; Genome, Fungal; Genomic Instability; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Protein Binding; Protein Methyltransferases; Protein Processing, Post-Translational; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins | 2008 |
Molecular regulation of H3K4 trimethylation by Wdr82, a component of human Set1/COMPASS.
Topics: Animals; Chromatin; Chromosomal Proteins, Non-Histone; DNA-Binding Proteins; HeLa Cells; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Macromolecular Substances; Methylation; Protein Methyltransferases; Protein Subunits; RNA, Small Interfering | 2008 |
Role for 53BP1 Tudor domain recognition of p53 dimethylated at lysine 382 in DNA damage signaling.
Topics: Amino Acid Sequence; DNA; DNA Damage; Histones; Humans; Intracellular Signaling Peptides and Proteins; Lysine; Methylation; Molecular Sequence Data; Peptides; Protein Structure, Tertiary; Signal Transduction; Substrate Specificity; Transfection; Tumor Suppressor p53-Binding Protein 1; Tumor Suppressor Protein p53 | 2008 |
Origin recognition complex (ORC) mediates histone 3 lysine 4 methylation through cooperation with Spp1 in Saccharomyces cerevisiae.
Topics: Chromatin; DNA-Binding Proteins; Fungal Proteins; Gene Expression Regulation, Fungal; Histone-Lysine N-Methyltransferase; Histones; Immunoprecipitation; Lysine; Methylation; Models, Biological; Origin Recognition Complex; Plasmids; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Temperature; Transcription Factors; Two-Hybrid System Techniques | 2008 |
Drosophila Kismet regulates histone H3 lysine 27 methylation and early elongation by RNA polymerase II.
Topics: Animals; Chromatin Assembly and Disassembly; Chromosomal Proteins, Non-Histone; DNA Helicases; DNA-Binding Proteins; Drosophila melanogaster; Drosophila Proteins; Epigenesis, Genetic; Genes, Insect; Histone-Lysine N-Methyltransferase; Histones; Homeodomain Proteins; Lysine; Methylation; Protein Processing, Post-Translational; RNA Polymerase II; Transcription Factors | 2008 |
H3K9 methylation regulates growth and development in Aspergillus fumigatus.
Topics: Animals; Aspergillus fumigatus; Cell Line; Fungal Proteins; Gene Expression Regulation, Fungal; Histone-Lysine N-Methyltransferase; Histones; Lysine; Macrophages; Methylation; Mice; Protein Processing, Post-Translational | 2008 |
Histone H3 K36 methylation is mediated by a trans-histone methylation pathway involving an interaction between Set2 and histone H4.
Topics: Antimetabolites; Blotting, Western; Chromatin; Chromatin Immunoprecipitation; Gene Expression Regulation, Fungal; Histones; Immunoblotting; Immunoprecipitation; Lysine; Methylation; Methyltransferases; Mutation; Nucleosomes; Phosphorylation; Protein Kinases; Protein Processing, Post-Translational; RNA Polymerase II; Saccharomyces cerevisiae Proteins; Transcription, Genetic; Uracil | 2008 |
A model for transmission of the H3K27me3 epigenetic mark.
Topics: Carrier Proteins; Catalysis; Cell Line; Cells, Cultured; Chromatin; DNA-Binding Proteins; Enhancer of Zeste Homolog 2 Protein; Epigenesis, Genetic; Fibroblasts; G1 Phase; Genes, Reporter; Histones; Humans; Kidney; Luciferases; Lysine; Methylation; Models, Biological; Mutation; Neoplasm Proteins; Nuclear Proteins; Polycomb Repressive Complex 2; Polycomb-Group Proteins; Promoter Regions, Genetic; Repressor Proteins; RNA, Small Interfering; S Phase; Transcription Factors; Transfection | 2008 |
The genomic landscapes of histone H3-Lys9 modifications of gene promoter regions and expression profiles in human bone marrow mesenchymal stem cells.
Topics: Acetylation; Bone Marrow Cells; Cell Cycle; Cell Proliferation; Cytokines; Flow Cytometry; Gene Expression Profiling; Gene Silencing; Genome, Human; Genomics; Histones; Humans; Lysine; Mesenchymal Stem Cells; Methylation; Oligonucleotide Array Sequence Analysis; Promoter Regions, Genetic; Signal Transduction | 2008 |
Prognostic significance of global histone modifications in resected squamous cell carcinoma of the esophagus.
Topics: Acetylation; Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Carcinoma, Squamous Cell; Cell Differentiation; Esophageal Neoplasms; Esophagectomy; Female; Histones; Humans; Immunohistochemistry; Kaplan-Meier Estimate; Lymphatic Metastasis; Lysine; Male; Methylation; Middle Aged; Neoplasm Metastasis; Neoplasm Staging; Protein Processing, Post-Translational; Retrospective Studies; Time Factors; Treatment Outcome | 2009 |
Post-translational modifications guard yeast from misaspartylation.
Topics: Amino Acid Sequence; Aminoacylation; Aspartate-tRNA Ligase; Aspartic Acid; Biotin; Gene Expression; Gentamicins; Glycosylation; Lysine; Mass Spectrometry; Methylation; Models, Molecular; Molecular Sequence Data; Protein Conformation; Protein Processing, Post-Translational; Proteome; Saccharomyces cerevisiae | 2008 |
Identification of two SET domain proteins required for methylation of lysine residues in yeast ribosomal protein Rpl42ab.
Topics: Cycloheximide; Gene Knockdown Techniques; Lysine; Methylation; Methyltransferases; Protein Structure, Tertiary; Protein Synthesis Inhibitors; Ribosomal Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins | 2008 |
H3K79 methylation profiles define murine and human MLL-AF4 leukemias.
Topics: Animals; Biomarkers, Tumor; Cell Differentiation; Cells, Cultured; Chromatin Immunoprecipitation; Female; Flow Cytometry; Gene Expression Profiling; Gene Expression Regulation, Leukemic; Gene Rearrangement; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Homeodomain Proteins; Humans; Immunophenotyping; Integrases; Leukemia, Myeloid, Acute; Lysine; Male; Methylation; Methyltransferases; Mice; Mice, Transgenic; Myeloid-Lymphoid Leukemia Protein; Oligonucleotide Array Sequence Analysis; Oncogene Proteins, Fusion; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Principal Component Analysis; Protein Methyltransferases; RNA, Small Interfering; Transcription, Genetic | 2008 |
High-throughput chromatin information enables accurate tissue-specific prediction of transcription factor binding sites.
Topics: Animals; Binding Sites; Cell Line; Chromatin; Embryonic Stem Cells; Genomics; Histones; Humans; Liver; Lysine; Methylation; Mice; Phylogeny; Regulatory Elements, Transcriptional; T-Lymphocytes; Transcription Factors; Transcription Initiation Site | 2009 |
The cytoplasm of mouse germinal vesicle stage oocytes can enhance somatic cell nuclear reprogramming.
Topics: Acetylation; Animals; Blastocyst; Cell Extracts; Cellular Reprogramming; Chromosomes, Mammalian; Cloning, Organism; Culture Media; Cytoplasm; Embryo, Mammalian; Embryonic Stem Cells; Female; Gene Expression Regulation, Developmental; Histones; Lamin Type A; Lysine; Methylation; Mice; Octamer Transcription Factor-3; Oocytes | 2008 |
Monomethylation of lysine 20 on histone H4 facilitates chromatin maturation.
Topics: Acetylation; Animals; Cell Extracts; Chromatin; Chromatin Assembly and Disassembly; Drosophila melanogaster; Drosophila Proteins; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Nucleosomes; Peptides; Protein Binding; S-Adenosylhomocysteine; Substrate Specificity | 2009 |
Genomic loss of microRNA-101 leads to overexpression of histone methyltransferase EZH2 in cancer.
Topics: 3' Untranslated Regions; Algorithms; Breast Neoplasms; Cell Line, Tumor; Disease Progression; DNA-Binding Proteins; Enhancer of Zeste Homolog 2 Protein; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Genome, Human; Histones; Humans; Lysine; Male; Methylation; MicroRNAs; Neoplasm Metastasis; Neoplasms; Polycomb Repressive Complex 2; Promoter Regions, Genetic; Prostatic Neoplasms; RNA, Small Interfering; Stomach Neoplasms; Transcription Factors | 2008 |
Enhancer requirement for histone methylation linked with gene activation.
Topics: Binding Sites; Chromatin Immunoprecipitation; Enhancer Elements, Genetic; Histones; Humans; K562 Cells; Lysine; Methylation; Mutation; NF-E2 Transcription Factor, p45 Subunit; Nucleosomes | 2008 |
Expression of histone H3 tails with combinatorial lysine modifications under the reprogrammed genetic code for the investigation on epigenetic markers.
Topics: Acetylation; Amino Acid Sequence; Base Sequence; Biomarkers; Chromobox Protein Homolog 5; Chromosomal Proteins, Non-Histone; Epigenesis, Genetic; Histones; Humans; Lysine; Methylation; Molecular Sequence Data; Peptides; Protein Biosynthesis; RNA, Messenger; Substrate Specificity | 2008 |
EZH1 mediates methylation on histone H3 lysine 27 and complements EZH2 in maintaining stem cell identity and executing pluripotency.
Topics: Animals; Cell Differentiation; Cell Line; DNA-Binding Proteins; Enhancer of Zeste Homolog 2 Protein; Genes, Regulator; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Mice; Models, Biological; Polycomb Repressive Complex 2; Stem Cells; Transcription Factors | 2008 |
H3K27me3 forms BLOCs over silent genes and intergenic regions and specifies a histone banding pattern on a mouse autosomal chromosome.
Topics: Algorithms; Animals; Chromatin Immunoprecipitation; Chromosome Banding; Chromosomes, Mammalian; DNA, Intergenic; Gene Silencing; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Mice; Models, Biological; Protein Methyltransferases; Protein Multimerization; Protein Processing, Post-Translational; Substrate Specificity | 2009 |
Stimulating conversations between HP1a and histone demethylase dKDM4A.
Topics: Animals; Chromobox Protein Homolog 5; Chromosomal Proteins, Non-Histone; Drosophila melanogaster; Histones; Lysine; Methylation; Models, Biological; Oxidoreductases, N-Demethylating; Protein Structure, Tertiary | 2008 |
A ncRNA modulates histone modification and mRNA induction in the yeast GAL gene cluster.
Topics: Acetyltransferases; Chromatin; DNA-Binding Proteins; Gene Expression Regulation, Fungal; Genes, Fungal; Glucose; Histones; Lysine; Methylation; Models, Biological; Multigene Family; Protein Processing, Post-Translational; Repressor Proteins; RNA, Messenger; RNA, Untranslated; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Transcription Factors; Transcription, Genetic | 2008 |
Heterochromatin protein 1a stimulates histone H3 lysine 36 demethylation by the Drosophila KDM4A demethylase.
Topics: Amino Acid Motifs; Animals; Chromobox Protein Homolog 5; Chromosomal Proteins, Non-Histone; Consensus Sequence; Dimerization; Drosophila melanogaster; Drosophila Proteins; Histone Demethylases; Histones; Larva; Lysine; Methylation; Oxidoreductases, N-Demethylating; Protein Binding; Protein Structure, Tertiary; Substrate Specificity | 2008 |
CDYL bridges REST and histone methyltransferases for gene repression and suppression of cellular transformation.
Topics: Cell Transformation, Neoplastic; Co-Repressor Proteins; DNA-Binding Proteins; Down-Regulation; Epithelial Cells; HeLa Cells; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; Hydro-Lyases; Lysine; Methylation; Multiprotein Complexes; Nerve Tissue Proteins; Oncogene Proteins, Viral; Papillomavirus E7 Proteins; Protein Binding; Protein Methyltransferases; Proteins; Proto-Oncogene Mas; Receptor, trkC; Repressor Proteins; RNA Interference; Transcription, Genetic | 2008 |
Corepressive action of CBP on androgen receptor transactivation in pericentric heterochromatin in a Drosophila experimental model system.
Topics: Acetylation; Amino Acid Sequence; Animals; Catalytic Domain; Cell Line, Tumor; Chromosomal Position Effects; Conserved Sequence; CREB-Binding Protein; Drosophila melanogaster; Drosophila Proteins; Euchromatin; Heterochromatin; Histone Deacetylases; Histones; Humans; Lysine; Methylation; Models, Genetic; Molecular Sequence Data; Promoter Regions, Genetic; Receptors, Androgen; Repressor Proteins; Sirtuins; Transcriptional Activation | 2009 |
Genome-wide histone methylation profile for heart failure.
Topics: Aged; Animals; Calcium-Binding Proteins; Chromatin Immunoprecipitation; Chromosome Mapping; Cluster Analysis; Epigenesis, Genetic; Female; Gene Expression Regulation; Genome; Heart Failure; Histones; Humans; Lysine; Male; Membrane Proteins; Methylation; Middle Aged; Muscle Proteins; Myocardium; Protein Processing, Post-Translational; Rats; Rats, Inbred Dahl; RNA, Messenger | 2009 |
Histone H3 lysine 4 trimethylation marks meiotic recombination initiation sites.
Topics: DNA Breaks, Double-Stranded; DNA Repair; DNA-Binding Proteins; Gene Expression Regulation, Fungal; Histone-Lysine N-Methyltransferase; Histones; Lysine; Meiosis; Methylation; Recombination, Genetic; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Transcription Factors | 2009 |
[5-aza-2'-deoxycytidine induces changes of histone H3-lysine 9 methylation in bladder tumor cells].
Topics: Antimetabolites, Antineoplastic; Azacitidine; Cell Line, Tumor; Cell Survival; Core Binding Factor Alpha 3 Subunit; Decitabine; DNA Methylation; Dose-Response Relationship, Drug; Histones; Humans; Lysine; Methylation; Promoter Regions, Genetic; Time Factors; Urinary Bladder Neoplasms | 2008 |
Genetic and genomewide analysis of simultaneous mutations in acetylated and methylated lysine residues in histone H3 in Saccharomyces cerevisiae.
Topics: Acetylation; Gene Expression Profiling; Gene Expression Regulation, Fungal; Genome-Wide Association Study; Genome, Fungal; Histones; Lysine; Methylation; Mutagenesis, Site-Directed; Mutation; Oligonucleotide Array Sequence Analysis; Phenotype; RNA, Fungal; RNA, Messenger; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Telomere | 2009 |
Proton affinity and zwitterion stability: new results from infrared spectroscopy and theory of cationized lysine and analogues in the gas phase.
Topics: Amines; Gases; Lysine; Metals, Alkali; Methylation; Photons; Protons; Quantum Theory; Spectrophotometry, Infrared | 2009 |
Histone H3 lysine 36 dimethylation (H3K36me2) is sufficient to recruit the Rpd3s histone deacetylase complex and to repress spurious transcription.
Topics: Animals; Genome, Human; HeLa Cells; Histone Deacetylase 2; Histone Deacetylases; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Multienzyme Complexes; Mutation; Repressor Proteins; Transcription, Genetic; Xenopus | 2009 |
Histone H3 Lys79 methylation is required for efficient nucleotide excision repair in a silenced locus of Saccharomyces cerevisiae.
Topics: Chromatin; DNA Repair; Gene Deletion; Gene Expression Regulation, Fungal; Gene Silencing; Genes, Mating Type, Fungal; Histone Deacetylases; Histones; Lysine; Methylation; Micrococcal Nuclease; Saccharomyces cerevisiae; Silent Information Regulator Proteins, Saccharomyces cerevisiae; Sirtuin 2; Sirtuins; Ultraviolet Rays | 2009 |
Differential chromatin marking of introns and expressed exons by H3K36me3.
Topics: Alternative Splicing; Animals; Binding Sites; Caenorhabditis elegans; Chromatin; Chromosome Mapping; Exons; Gene Expression Regulation; Gene Silencing; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Introns; Lysine; Methylation; Open Reading Frames; Protein Binding; Protein Methyltransferases; Transcription, Genetic | 2009 |
Lysine methylation of nuclear co-repressor receptor interacting protein 140.
Topics: 3T3-L1 Cells; Adaptor Proteins, Signal Transducing; Adipocytes; Amino Acid Sequence; Animals; Arginine; Cell Differentiation; Lysine; Methylation; Mice; Molecular Sequence Data; Mutation; Nuclear Proteins; Nuclear Receptor Interacting Protein 1; Protein Processing, Post-Translational | 2009 |
Monomethylation of histone H4-lysine 20 is involved in chromosome structure and stability and is essential for mouse development.
Topics: Animals; Cell Cycle; Chromosomal Instability; Chromosome Structures; DNA Damage; Embryonic Stem Cells; Histone-Lysine N-Methyltransferase; Histones; Interphase; Lysine; Methylation; Mice; Mice, Mutant Strains | 2009 |
Methylation-state-specific recognition of histones by the MBT repeat protein L3MBTL2.
Topics: Histones; Humans; Lysine; Methylation; Models, Molecular; Nuclear Proteins; Peptides; Protein Binding; Repetitive Sequences, Amino Acid; Repressor Proteins; Transcription Factors | 2009 |
Processing the H3K36me3 signature.
Topics: Animals; Caenorhabditis elegans; Gene Expression Profiling; Gene Expression Regulation; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Metabolic Networks and Pathways; Methylation; Models, Biological; Protein Methyltransferases; Protein Processing, Post-Translational | 2009 |
Regulation of Set9-mediated H4K20 methylation by a PWWP domain protein.
Topics: Amino Acid Sequence; Chromatin; Chromosomal Proteins, Non-Histone; DNA Damage; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Lysine; Mass Spectrometry; Methylation; Molecular Sequence Data; Mutation; Protein Methyltransferases; Protein Structure, Tertiary; Schizosaccharomyces; Schizosaccharomyces pombe Proteins | 2009 |
Negative regulation of NF-kappaB action by Set9-mediated lysine methylation of the RelA subunit.
Topics: Amino Acid Sequence; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Humans; Lysine; Methylation; Molecular Sequence Data; NF-kappa B; Promoter Regions, Genetic; Protein Methyltransferases; Protein Subunits; Recombinant Fusion Proteins; RNA Interference; Transcription Factor RelA; Transcriptional Activation; Tumor Necrosis Factor-alpha | 2009 |
Genome-wide profiling of histone h3 lysine 4 and lysine 27 trimethylation reveals an epigenetic signature in prostate carcinogenesis.
Topics: Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Genome, Human; Histones; Humans; Immunoprecipitation; Lysine; Male; Methylation; MicroRNAs; Oligonucleotide Array Sequence Analysis; Prostatic Neoplasms | 2009 |
Incorporating structural characteristics for identification of protein methylation sites.
Topics: Arginine; Asparagine; Binding Sites; Computer Simulation; Glutamic Acid; Lysine; Methylation; Protein Conformation; Proteins; Surface Properties | 2009 |
MLL5, a trithorax homolog, indirectly regulates H3K4 methylation, represses cyclin A2 expression, and promotes myogenic differentiation.
Topics: Animals; Cell Differentiation; Chromosomal Proteins, Non-Histone; Cyclin A; Cyclin A2; Drosophila Proteins; G1 Phase; Gene Knockdown Techniques; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Mice; Myoblasts; Protein Binding; Repressor Proteins; Response Elements; RNA Interference; S Phase; Sequence Homology, Amino Acid; Transcription Factors; Transcription, Genetic | 2009 |
Plasmodium falciparum heterochromatin protein 1 binds to tri-methylated histone 3 lysine 9 and is linked to mutually exclusive expression of var genes.
Topics: Amino Acid Sequence; Animals; Cell Nucleus; Chromobox Protein Homolog 5; Chromosomal Proteins, Non-Histone; Gene Expression Regulation; Histones; Lysine; Methylation; Models, Molecular; Molecular Sequence Data; Peptides; Plasmodium falciparum; Protein Multimerization; Protein Structure, Tertiary; Protozoan Proteins; Repetitive Sequences, Nucleic Acid; Telomere; Virulence Factors | 2009 |
Functional conservation of Asxl2, a murine homolog for the Drosophila enhancer of trithorax and polycomb group gene Asx.
Topics: Animals; Animals, Newborn; Blotting, Western; Chromosomal Proteins, Non-Histone; Drosophila melanogaster; Drosophila Proteins; Embryo, Mammalian; Gene Transfer Techniques; Heart; Histones; Lysine; Methylation; Mice; Polycomb-Group Proteins; Repressor Proteins; Reverse Transcriptase Polymerase Chain Reaction; Skeleton | 2009 |
Distinct DNA methylation patterns characterize differentiated human embryonic stem cells and developing human fetal liver.
Topics: Binding Sites; Cell Differentiation; Cell Line; Cells, Cultured; Chromosome Mapping; Cluster Analysis; CpG Islands; DNA Methylation; Embryonic Stem Cells; Gene Expression Profiling; Genome, Human; Histones; Humans; Liver; Lysine; Methylation; Promoter Regions, Genetic; Sequence Analysis, DNA | 2009 |
Histone H3 lysine 27 trimethylation in adult differentiated colon associated to cancer DNA hypermethylation.
Topics: Adult; Colon; Colonic Neoplasms; DNA Methylation; Embryonic Stem Cells; Histones; Humans; Lysine; Methylation; Polycomb-Group Proteins; Repressor Proteins | 2009 |
Differences in lysine pKa values may be used to improve NMR signal dispersion in reductively methylated proteins.
Topics: Calcium; Calmodulin; Carbon Isotopes; Glutathione Transferase; Hydrogen-Ion Concentration; Isoelectric Point; Lysine; Methylation; Models, Molecular; Muramidase; Nuclear Magnetic Resonance, Biomolecular; Protein Conformation; Proteins; Troponin C | 2009 |
Regulation of DNMT1 stability through SET7-mediated lysine methylation in mammalian cells.
Topics: Animals; Cell Cycle; Chlorocebus aethiops; COS Cells; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; Enzyme Stability; HeLa Cells; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Humans; Lysine; Methylation; RNA, Small Interfering; Transfection | 2009 |
Computational identification of protein methylation sites through bi-profile Bayes feature extraction.
Topics: Arginine; Bayes Theorem; Lysine; Methylation; Proteins; Sensitivity and Specificity | 2009 |
Aberrant histone modifications at the thyrotropin-releasing hormone gene in resistance to thyroid hormone: analysis of F455S mutant thyroid hormone receptor.
Topics: Acetylation; Deoxyadenosines; Histone Deacetylase Inhibitors; Histones; Humans; Lysine; Methylation; Receptors, Thyroid Hormone; Thionucleosides; Thyroid Hormone Receptors beta; Thyroid Hormone Resistance Syndrome; Thyrotropin-Releasing Hormone | 2009 |
Methyl group migration during the fragmentation of singly charged ions of trimethyllysine-containing peptides: precaution of using MS/MS of singly charged ions for interrogating peptide methylation.
Topics: Arginine; Cell Line, Tumor; Histones; Humans; Lysine; Methylation; Peptide Fragments; Proline; Saccharomyces cerevisiae Proteins; Spectrometry, Mass, Electrospray Ionization; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2009 |
Insulin induced alteration in post-translational modifications of histone H3 under a hyperglycemic condition in L6 skeletal muscle myoblasts.
Topics: Acetylation; Chromatin Assembly and Disassembly; DNA Methylation; Enzyme Activation; Glucose; Histones; Insulin; Lysine; Methylation; Myoblasts, Skeletal; Okadaic Acid; Phosphorylation; Phosphotransferases; Protein Processing, Post-Translational; Reactive Oxygen Species | 2009 |
PRIP promotes tumor formation through enhancing serum-responsive factor-mediated FOS expression.
Topics: Animals; Cell Line, Tumor; Cell Proliferation; Female; Gene Expression Regulation, Neoplastic; Histones; Humans; Intracellular Signaling Peptides and Proteins; Lysine; Mammary Neoplasms, Animal; Methylation; Mice; Mice, Knockout; Neoplasms; Nuclear Receptor Coactivators; Promoter Regions, Genetic; Protein Binding; Proto-Oncogene Proteins c-fos; ras Proteins; Serum Response Factor | 2009 |
Heterogeneous nuclear ribonucleoprotein L Is a subunit of human KMT3a/Set2 complex required for H3 Lys-36 trimethylation activity in vivo.
Topics: Cell Line; Heterogeneous-Nuclear Ribonucleoprotein L; Histone-Lysine N-Methyltransferase; Histones; Humans; Kidney; Lysine; Methylation; Methyltransferases; Peptide Fragments; Protein Subunits; Ribonucleases; Transfection | 2009 |
Preparation of recombinant peptides with site- and degree-specific lysine (13)C-methylation.
Topics: Carbon Isotopes; Chromatography, Liquid; Lysine; Methylation; Nuclear Magnetic Resonance, Biomolecular; Peptides; Recombinant Proteins | 2009 |
Multiple lysine methylation of PCAF by Set9 methyltransferase.
Topics: Amino Acid Sequence; Cell Line; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Humans; Lysine; Methylation; Molecular Sequence Data; p300-CBP Transcription Factors; Substrate Specificity | 2009 |
Functional connection between histone acetyltransferase Gcn5p and methyltransferase Hmt1p.
Topics: Acetylation; Arginine; Gene Regulatory Networks; Histone Acetyltransferases; Histones; Lysine; Methylation; Mutation; Protein Binding; Protein-Arginine N-Methyltransferases; Recombinant Proteins; Repressor Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins | 2009 |
High-affinity binding of Chp1 chromodomain to K9 methylated histone H3 is required to establish centromeric heterochromatin.
Topics: Amino Acid Sequence; Argonaute Proteins; Binding Sites; Cell Cycle Proteins; Centromere; Chromosomal Proteins, Non-Histone; Crystallography, X-Ray; Heterochromatin; Histones; Lysine; Methylation; Models, Molecular; Molecular Sequence Data; Mutation; Protein Structure, Tertiary; RNA-Binding Proteins; RNA, Small Interfering; Schizosaccharomyces pombe Proteins | 2009 |
Differential epigenetic modifications of histones at the myosin heavy chain genes in fast and slow skeletal muscle fibers and in response to muscle unloading.
Topics: Acetylation; Actins; Animals; Chromatin Assembly and Disassembly; Chromatin Immunoprecipitation; Epigenesis, Genetic; Female; Gene Expression Regulation; Hindlimb Suspension; Histones; Lysine; Methylation; Models, Animal; Muscle Fibers, Fast-Twitch; Muscle Fibers, Slow-Twitch; Myosin Heavy Chains; Phenotype; Protein Isoforms; Protein Processing, Post-Translational; Rats; Rats, Sprague-Dawley; RNA Precursors; RNA, Messenger; Transcription, Genetic | 2009 |
Effects of nickel, chromate, and arsenite on histone 3 lysine methylation.
Topics: Arsenites; Cell Line, Tumor; Cell Transformation, Neoplastic; Chromates; Dose-Response Relationship, Drug; Gene Expression Regulation, Neoplastic; Histones; Humans; Lung Neoplasms; Lysine; Methylation; Nickel; Potassium Compounds; Protein Processing, Post-Translational; Sodium Compounds; Time Factors | 2009 |
Epigenetic inheritance through self-recruitment of the polycomb repressive complex 2.
Topics: Animals; Drosophila melanogaster; Epigenesis, Genetic; Evolution, Molecular; Humans; Lysine; Methylation; Polycomb-Group Proteins; Protein Binding; Repressor Proteins | 2009 |
An alpha motif at Tas3 C terminus mediates RITS cis spreading and promotes heterochromatic gene silencing.
Topics: Amino Acid Motifs; Carrier Proteins; Centromere; Chromatin Assembly and Disassembly; Chromatin Immunoprecipitation; Chromatography, Gel; Crystallography, X-Ray; Gene Silencing; Heterochromatin; Histones; Lysine; Methylation; Models, Molecular; Mutagenesis, Site-Directed; Protein Structure, Tertiary; RNA-Induced Silencing Complex; RNA, Small Interfering; Schizosaccharomyces; Schizosaccharomyces pombe Proteins | 2009 |
Changes in histone methylation during human oocyte maturation and IVF- or ICSI-derived embryo development.
Topics: Arginine; Blastocyst; Cells, Cultured; Embryo Culture Techniques; Female; Fertilization in Vitro; Fluorescent Antibody Technique; Histones; Humans; Lysine; Male; Meiosis; Methylation; Microscopy, Confocal; Oocytes; Protein Processing, Post-Translational; Sperm Injections, Intracytoplasmic; Zygote | 2010 |
LSD1 demethylates histone and non-histone proteins.
Topics: Animals; Histone Demethylases; Histones; Humans; Lysine; Methylation; Mice; Oxidoreductases, N-Demethylating; Protein Processing, Post-Translational; Proteins | 2009 |
Regulation of H3K4 trimethylation via Cps40 (Spp1) of COMPASS is monoubiquitination independent: implication for a Phe/Tyr switch by the catalytic domain of Set1.
Topics: DNA-Binding Proteins; Histone-Lysine N-Methyltransferase; Histones; Humans; Infant; Lysine; Methylation; Models, Molecular; Phenylalanine; Protein Structure, Tertiary; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Tyrosine; Ubiquitination | 2009 |
Novel epigenetic regulation of skeletal muscle myosin heavy chain genes. Focus on "Differential epigenetic modifications of histones at the myosin heavy chain genes in fast and slow skeletal muscle fibers and in response to muscle unloading".
Topics: Acetylation; Actins; Animals; Chromatin Assembly and Disassembly; Epigenesis, Genetic; Gene Expression Regulation; Hindlimb Suspension; Histones; Lysine; Methylation; Models, Animal; Muscle Fibers, Fast-Twitch; Muscle Fibers, Slow-Twitch; Myosin Heavy Chains; Phenotype; Protein Isoforms; Protein Processing, Post-Translational; Rats; Rats, Sprague-Dawley; RNA Precursors; RNA, Messenger; Transcription, Genetic | 2009 |
A novel mammalian flavin-dependent histone demethylase.
Topics: Amino Acid Sequence; Animals; Chromatin; Cloning, Molecular; Epigenesis, Genetic; Flavins; Histones; Hydrogen-Ion Concentration; Kinetics; Lysine; Methylation; Mice; Molecular Sequence Data; Oxidoreductases, N-Demethylating; Sequence Homology, Amino Acid; Substrate Specificity; Zinc | 2009 |
H3 lysine 4 di- and tri-methylation deposited by cryptic transcription attenuates promoter activation.
Topics: Cytoplasm; Gene Expression Regulation, Fungal; Histone Deacetylases; Histones; Lysine; Methylation; Promoter Regions, Genetic; Protein Binding; Repressor Proteins; RNA Polymerase II; RNA Stability; RNA, Messenger; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Signal Transduction; Transcription, Genetic | 2009 |
Genetically Derepressed Nucleoplasmic Stellate Protein in Spermatocytes of D. melanogaster interacts with the catalytic subunit of protein kinase 2 and carries histone-like lysine-methylated mark.
Topics: Animals; Casein Kinase II; Catalytic Domain; Cell Fractionation; Cell Nucleus; Drosophila melanogaster; Drosophila Proteins; Immunoprecipitation; Insect Proteins; Lysine; Male; Methylation; Microscopy, Fluorescence; Protein Binding; Protein Interaction Mapping; Protein Kinases; Spermatocytes | 2009 |
Haematopoietic malignancies caused by dysregulation of a chromatin-binding PHD finger.
Topics: Amino Acid Motifs; Animals; Cell Transformation, Neoplastic; Cells, Cultured; Chromatin; Epigenesis, Genetic; Gene Expression Regulation, Developmental; Genes, Homeobox; Hematologic Neoplasms; Hematopoiesis; Hematopoietic Stem Cells; Histones; Humans; Intracellular Signaling Peptides and Proteins; Lysine; Magnetic Resonance Spectroscopy; Methylation; Mice; Models, Molecular; Nuclear Pore Complex Proteins; Oncogene Proteins, Fusion; Protein Binding; Protein Conformation; Retinoblastoma-Binding Protein 2; Transcription, Genetic; Tumor Suppressor Proteins | 2009 |
Modifications of histone H3 at lysine 9 on the adiponectin gene in 3T3-L1 adipocytes.
Topics: 3T3-L1 Cells; Acetylation; Adipocytes; Adiponectin; Animals; Gene Expression; Gene Expression Regulation; Histones; Insulin Resistance; Lysine; Methylation; Mice; Protein Processing, Post-Translational; Transcriptional Activation; Tumor Necrosis Factor-alpha | 2009 |
Visions: the art of science.
Topics: Animals; Biomarkers; Chromatin Assembly and Disassembly; Lysine; Male; Methylation; Mice; Phthalic Acids; Proto-Oncogene Proteins c-akt; Seminiferous Epithelium; Stress, Physiological | 2009 |
Epigenetic marks for chromosome imprinting during spermatogenesis in coccids.
Topics: Acetylation; Animals; Cell Nucleus; Chromatin Assembly and Disassembly; Epigenesis, Genetic; Female; Genomic Imprinting; Hemiptera; Heterochromatin; Histones; Immunohistochemistry; Insect Proteins; Lysine; Male; Methylation; Microscopy, Fluorescence; Nuclear Proteins; Spermatogenesis | 2009 |
Dynamic chromatin remodeling events in hippocampal neurons are associated with NMDA receptor-mediated activation of Bdnf gene promoter 1.
Topics: Acetylation; Analysis of Variance; Animals; Azacitidine; Brain-Derived Neurotrophic Factor; Chromatin Assembly and Disassembly; Chromatin Immunoprecipitation; DNA-Binding Proteins; Embryo, Mammalian; Enzyme Inhibitors; Exons; Hippocampus; Histone Deacetylase 1; Histone Deacetylases; Histones; Hydroxamic Acids; In Vitro Techniques; Lysine; Methyl-CpG-Binding Protein 2; Methylation; N-Methylaspartate; Neurons; Promoter Regions, Genetic; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Repressor Proteins; RNA, Messenger; Time Factors; Transcription Factors | 2009 |
A histone H3 lysine 36 trimethyltransferase links Nkx2-5 to Wolf-Hirschhorn syndrome.
Topics: Animals; DNA-Binding Proteins; Gene Expression Regulation; Histone-Lysine N-Methyltransferase; Histones; Homeobox Protein Nkx-2.5; Homeodomain Proteins; Lysine; Methylation; Mice; Mice, Inbred C57BL; Nanog Homeobox Protein; Protein Binding; Repressor Proteins; Transcription Factors; Transcription, Genetic; Wolf-Hirschhorn Syndrome | 2009 |
Pygo2 expands mammary progenitor cells by facilitating histone H3 K4 methylation.
Topics: Animals; beta Catenin; Cell Cycle; Cell Proliferation; Gene Expression Regulation; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; Intracellular Signaling Peptides and Proteins; Lysine; Mammary Glands, Animal; Methylation; Mice; Phenotype; Stem Cells; Wnt Proteins | 2009 |
Sirtuin 1 functionally and physically interacts with disruptor of telomeric silencing-1 to regulate alpha-ENaC transcription in collecting duct.
Topics: Aldosterone; Animals; Chromatin; Epithelial Sodium Channels; Gene Expression Regulation; Gene Knockdown Techniques; Histone Deacetylases; Histone-Lysine N-Methyltransferase; Histones; Immunoprecipitation; Kidney Tubules, Collecting; Lysine; Methylation; Methyltransferases; Mice; Promoter Regions, Genetic; Protein Binding; Receptors, Mineralocorticoid; RNA, Messenger; Sirtuin 1; Sirtuins; Transcription, Genetic | 2009 |
Molecular recognition of histone lysine methylation by the Polycomb group repressor dSfmbt.
Topics: Amino Acid Sequence; Animals; Binding Sites; Crystallography, X-Ray; Drosophila melanogaster; Drosophila Proteins; Histones; Humans; Lysine; Methylation; Models, Molecular; Molecular Sequence Data; Point Mutation; Polycomb Repressive Complex 1; Polycomb-Group Proteins; Protein Binding; Protein Structure, Tertiary; Repressor Proteins; Sequence Alignment | 2009 |
The HP1alpha-CAF1-SetDB1-containing complex provides H3K9me1 for Suv39-mediated K9me3 in pericentric heterochromatin.
Topics: Animals; Chromatin Assembly Factor-1; Chromobox Protein Homolog 5; Chromosomal Proteins, Non-Histone; DNA-Binding Proteins; HeLa Cells; Heterochromatin; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Mice; Models, Biological; Protein Methyltransferases; Protein Transport; Repressor Proteins; S Phase | 2009 |
Lung cancer-associated JmjC domain protein mdig suppresses formation of tri-methyl lysine 9 of histone H3.
Topics: Amino Acid Sequence; Chromatin Immunoprecipitation; Dioxygenases; F-Box Proteins; Histone Demethylases; Histones; Humans; Jumonji Domain-Containing Histone Demethylases; Lung Neoplasms; Lysine; Methylation; Molecular Sequence Data; Nuclear Proteins; Oxidoreductases, N-Demethylating; Promoter Regions, Genetic; Protein Interaction Domains and Motifs; RNA Polymerase I; RNA, Ribosomal; RNA, Small Interfering; Sequence Alignment | 2009 |
Genome-wide analysis of mono-, di- and trimethylation of histone H3 lysine 4 in Arabidopsis thaliana.
Topics: Arabidopsis; Arabidopsis Proteins; Cytosine; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Gene Expression Profiling; Gene Expression Regulation, Plant; Genes, Plant; Genome, Plant; Histones; Lysine; Methylation; Transcription, Genetic | 2009 |
ncRNA transcription makes its mark.
Topics: Histones; Lysine; Methylation; Promoter Regions, Genetic; RNA, Untranslated; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Transcription, Genetic | 2009 |
Targeted metabolomic evaluation of arginine methylation and cardiovascular risks: potential mechanisms beyond nitric oxide synthase inhibition.
Topics: Aged; Arginine; Biomarkers; C-Reactive Protein; Cardiovascular Diseases; Chromatography, High Pressure Liquid; Citrulline; Coronary Artery Disease; Creatinine; Female; Humans; Lysine; Male; Metabolomics; Methylation; Middle Aged; Nitric Oxide Synthase; Odds Ratio; omega-N-Methylarginine; Ornithine; Prognosis; Prospective Studies; Protein Processing, Post-Translational; Risk Assessment; Risk Factors; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Time Factors | 2009 |
Epigenetic profiling at mouse imprinted gene clusters reveals novel epigenetic and genetic features at differentially methylated regions.
Topics: Animals; Chromatin Immunoprecipitation; Chromosome Mapping; Chromosomes, Mammalian; CpG Islands; DNA Methylation; Epigenesis, Genetic; Female; Genome-Wide Association Study; Genomic Imprinting; Histones; Humans; Lysine; Male; Methylation; Mice; Multigene Family; Repetitive Sequences, Nucleic Acid; RNA, Long Noncoding; RNA, Untranslated; Short Interspersed Nucleotide Elements; Spermatozoa | 2009 |
Control of alternative splicing through siRNA-mediated transcriptional gene silencing.
Topics: Alternative Splicing; Animals; Argonaute Proteins; Base Sequence; Carcinoma, Hepatocellular; Chromobox Protein Homolog 5; Epigenesis, Genetic; Eukaryotic Initiation Factors; Exons; Fibronectins; Gene Knockdown Techniques; HeLa Cells; Heterochromatin; Histones; Humans; Liver Neoplasms; Lysine; Male; Methylation; Mice; Oligonucleotides, Antisense; Promoter Regions, Genetic; Ribonuclease III; RNA Interference; RNA Polymerase II; RNA, Small Interfering; Transcription, Genetic | 2009 |
Epigenetics of human T cells during the G0-->G1 transition.
Topics: Cells, Cultured; Chromatin Immunoprecipitation; CpG Islands; DNA Methylation; Epigenesis, Genetic; G1 Phase; Gene Expression Profiling; Genome-Wide Association Study; Histones; Humans; Lysine; Methylation; Nucleosomes; Promoter Regions, Genetic; Protein Binding; Resting Phase, Cell Cycle; T-Lymphocytes; Transcription Initiation Site; Transcription, Genetic | 2009 |
Mapping of lysine monomethylation of linker histones in human breast and its cancer.
Topics: Aged; Breast; Breast Neoplasms; Female; Histones; Humans; Linear Models; Lysine; Methylation; Middle Aged; Peptide Fragments; Peptide Mapping; Proteomics; Tandem Mass Spectrometry | 2009 |
On the mechanism of multiple lysine methylation by the human mixed lineage leukemia protein-1 (MLL1) core complex.
Topics: DNA-Binding Proteins; Gene Rearrangement; Histone-Lysine N-Methyltransferase; Histones; Humans; Intracellular Signaling Peptides and Proteins; Leukemia; Lysine; Methylation; Multiprotein Complexes; Myeloid-Lymphoid Leukemia Protein; Nuclear Proteins; Retinol-Binding Proteins, Cellular; Transcription Factors | 2009 |
Synaptonemal complex assembly and H3K4Me3 demethylation determine DIDO3 localization in meiosis.
Topics: Amino Acid Sequence; Animals; DNA-Binding Proteins; Epigenesis, Genetic; Histones; Lysine; Male; Meiosis; Methylation; Mice; Spermatocytes; Synaptonemal Complex; Transcription Factors | 2009 |
Degrees make all the difference: the multifunctionality of histone H4 lysine 20 methylation.
Topics: Animals; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation | 2009 |
WDR5, a complexed protein.
Topics: Amino Acid Motifs; Histone-Lysine N-Methyltransferase; Histones; Humans; Intracellular Signaling Peptides and Proteins; Lysine; Methylation; Models, Molecular; Multiprotein Complexes; Myeloid-Lymphoid Leukemia Protein; Protein Conformation; Protein Subunits; Saccharomyces cerevisiae Proteins | 2009 |
High-resolution analysis of epigenetic changes associated with X inactivation.
Topics: Animals; Cell Differentiation; Cells, Cultured; Chromatin Immunoprecipitation; Embryonic Stem Cells; Epigenesis, Genetic; Female; Gene Expression Profiling; Genome-Wide Association Study; Histones; Kinetics; Lysine; Male; Methylation; Mice; Mice, Inbred C3H; Oligonucleotide Array Sequence Analysis; Polymorphism, Single Nucleotide; Repetitive Sequences, Nucleic Acid; Reverse Transcriptase Polymerase Chain Reaction; RNA, Long Noncoding; RNA, Untranslated; Transcription, Genetic; X Chromosome; X Chromosome Inactivation | 2009 |
The multiple endocrine neoplasia type 1 (MEN1) tumor suppressor regulates peroxisome proliferator-activated receptor gamma-dependent adipocyte differentiation.
Topics: 3T3-L1 Cells; Adipocytes; Animals; Cell Differentiation; Fatty Acid-Binding Proteins; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Histones; Humans; Ligands; Lysine; Methylation; Mice; PPAR gamma; Protein Binding; Protein Structure, Tertiary; Proto-Oncogene Proteins; Transcription, Genetic | 2009 |
Cooperation between the INO80 complex and histone chaperones determines adaptation of stress gene transcription in the yeast Saccharomyces cerevisiae.
Topics: Adaptation, Biological; Copper; Gene Expression Regulation, Fungal; Histones; Lysine; Methylation; Molecular Chaperones; Mutation; Osmosis; Phosphorylation; Protein Binding; RNA Polymerase II; RNA, Messenger; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Stress, Physiological; Transcription, Genetic | 2009 |
Mass spectrometry analysis of the variants of histone H3 and H4 of soybean and their post-translational modifications.
Topics: Acetylation; Amino Acid Sequence; Chromatography, Liquid; Glycine max; Histones; Lysine; Methylation; Molecular Sequence Data; Plant Proteins; Protein Processing, Post-Translational; Sequence Alignment; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2009 |
The presence of RNA polymerase II, active or stalled, predicts epigenetic fate of promoter CpG islands.
Topics: Cell Line; Cell Line, Tumor; Chromatin Immunoprecipitation; CpG Islands; DNA Methylation; Female; Genetic Predisposition to Disease; Histones; Humans; Lysine; Male; Methylation; Oligonucleotide Array Sequence Analysis; Promoter Regions, Genetic; Prostatic Neoplasms; Protein Binding; RNA Polymerase II; Transcription, Genetic | 2009 |
Linking cell cycle to histone modifications: SBF and H2B monoubiquitination machinery and cell-cycle regulation of H3K79 dimethylation.
Topics: Cell Cycle; DNA-Binding Proteins; DNA, Intergenic; Gene Expression Profiling; Gene Expression Regulation, Fungal; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Nuclear Proteins; Oligonucleotide Array Sequence Analysis; Open Reading Frames; Promoter Regions, Genetic; Protein Processing, Post-Translational; Repressor Proteins; RNA-Binding Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Signal Transduction; Time Factors; Transcription Factors; Transcription, Genetic; Ubiquitin-Conjugating Enzymes; Ubiquitination | 2009 |
Histone methylation and decreased expression of TrkB.T1 in orbital frontal cortex of suicide completers.
Topics: Adult; Depression; Down-Regulation; Female; Histones; Humans; Immunoprecipitation; Lysine; Methylation; Middle Aged; Prefrontal Cortex; Receptor, trkB; Suicide, Attempted | 2009 |
Global analysis of H3K4 methylation defines MLL family member targets and points to a role for MLL1-mediated H3K4 methylation in the regulation of transcriptional initiation by RNA polymerase II.
Topics: Animals; Chromatin; DNA, Intergenic; Gene Expression Regulation; Genes, Homeobox; Genome; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Mice; Myeloid-Lymphoid Leukemia Protein; Proto-Oncogene Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA Polymerase II; Transcription, Genetic | 2009 |
Regulation of vitamin D receptor function in MEN1-related parathyroid adenomas.
Topics: Animals; Cell Line; Gene Expression Regulation; Histones; Humans; Lysine; Methylation; Mice; Mice, Knockout; Multiple Endocrine Neoplasia Type 1; Parathyroid Neoplasms; Proto-Oncogene Proteins; Receptors, Calcitriol; Two-Hybrid System Techniques | 2009 |
The interaction of NSBP1/HMGN5 with nucleosomes in euchromatin counteracts linker histone-mediated chromatin compaction and modulates transcription.
Topics: Animals; Binding Sites; Cell Line, Transformed; Chromatin Assembly and Disassembly; Euchromatin; Gene Expression Profiling; Histones; HMGN Proteins; Lysine; Methylation; Mice; Microscopy, Confocal; Models, Molecular; NIH 3T3 Cells; Nucleic Acid Conformation; Nucleosomes; Protein Conformation; Protein Processing, Post-Translational; Protein Structure, Tertiary; Recombinant Fusion Proteins; RNA Interference; Trans-Activators; Transcription, Genetic; Transfection | 2009 |
Role of the polycomb protein EED in the propagation of repressive histone marks.
Topics: Allosteric Regulation; Animals; Cell Line; Chromatin; Crystallography, X-Ray; Drosophila melanogaster; Drosophila Proteins; Enzyme Activation; Gene Silencing; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Models, Biological; Models, Molecular; Nuclear Proteins; Nucleosomes; Polycomb Repressive Complex 2; Protein Binding; Protein Structure, Tertiary; Repressor Proteins; Substrate Specificity | 2009 |
A systematic evaluation of the compatibility of histones containing methyl-lysine analogues with biochemical reactions.
Topics: Histocompatibility Antigens; Histone Demethylases; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Protein Binding | 2009 |
Genetically encoding N(epsilon)-methyl-L-lysine in recombinant histones.
Topics: Escherichia coli; Histones; Lysine; Methylation; Mutagenesis, Site-Directed; Recombinant Proteins | 2009 |
Linking the cell cycle to histone modifications: Dot1, G1/S, and cycling K79me2.
Topics: Cell Cycle; DNA, Intergenic; G1 Phase; Gene Expression Regulation, Fungal; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Nuclear Proteins; Nucleosomes; Open Reading Frames; Promoter Regions, Genetic; Protein Processing, Post-Translational; S Phase; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Ubiquitination | 2009 |
Investigating repetitively matching short sequencing reads: the enigmatic nature of H3K9me3.
Topics: Genome-Wide Association Study; Histones; Humans; Lysine; Methylation; Repetitive Sequences, Nucleic Acid; Sequence Alignment; Sequence Analysis, DNA | 2009 |
Validation-based insertional mutagenesis identifies lysine demethylase FBXL11 as a negative regulator of NFkappaB.
Topics: Antibiotics, Antineoplastic; Bleomycin; Blotting, Northern; Blotting, Western; Cell Line; Cell Survival; F-Box Proteins; Genetic Vectors; Green Fluorescent Proteins; Histones; HT29 Cells; Humans; Jumonji Domain-Containing Histone Demethylases; Lysine; Methylation; Microscopy, Fluorescence; Mutagenesis, Insertional; Mutation; NF-kappa B; Oxidoreductases, N-Demethylating; Recombinant Fusion Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Small Interfering; Transfection | 2009 |
Multimerization and H3K9me3 binding are required for CDYL1b heterochromatin association.
Topics: Alternative Splicing; Amino Acid Sequence; Animals; Cells, Cultured; Co-Repressor Proteins; Heterochromatin; Histones; Humans; Hydro-Lyases; Lysine; Methylation; Mice; Models, Molecular; Molecular Sequence Data; Protein Isoforms; Protein Multimerization; Protein Structure, Quaternary; Proteins; Sequence Alignment | 2009 |
Histone modifications associated with drought tolerance in the desert plant Zygophyllum dumosum Boiss.
Topics: Adaptation, Physiological; Cell Nucleus Size; Desert Climate; Droughts; Genes, Plant; Histones; Humans; Lysine; Methylation; Methyltransferases; Plant Leaves; Plant Proteins; Protein Processing, Post-Translational; Repressor Proteins; Seasons; Zygophyllum | 2009 |
BBAP monoubiquitylates histone H4 at lysine 91 and selectively modulates the DNA damage response.
Topics: Acetylation; Apoptosis; Cell Line; Cell Proliferation; DNA Damage; Doxorubicin; HeLa Cells; Histone-Lysine N-Methyltransferase; Histones; Humans; Hydroxyurea; Intracellular Signaling Peptides and Proteins; Lysine; Methylation; Nucleosomes; Protein Binding; Protein Processing, Post-Translational; Recombinant Proteins; RNA, Small Interfering; Tumor Suppressor p53-Binding Protein 1; Ubiquitin; Ubiquitin-Protein Ligases; Ubiquitination | 2009 |
Histone H2B ubiquitylation is not required for histone H3 methylation at lysine 4 in tetrahymena.
Topics: Amino Acid Sequence; Animals; Cluster Analysis; Histones; Humans; Lysine; Methylation; Microarray Analysis; Molecular Sequence Data; Protozoan Proteins; Sequence Alignment; Tetrahymena; Ubiquitin-Protein Ligases; Ubiquitination | 2009 |
Set2-dependent K36 methylation is regulated by novel intratail interactions within H3.
Topics: Amino Acid Sequence; Gene Expression Regulation, Fungal; Histones; Lysine; Methylation; Methyltransferases; Molecular Sequence Data; Mutation; Open Reading Frames; Phenotype; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Transcription, Genetic | 2009 |
Methylation, a new epigenetic mark for protein stability.
Topics: Animals; Epigenesis, Genetic; Genetic Markers; Histone-Lysine N-Methyltransferase; Humans; Lysine; Methylation; Protein Stability; Proteins | 2009 |
Structural studies of a four-MBT repeat protein MBTD1.
Topics: Amino Acid Sequence; Arginine; Chromatin; Chromosomal Proteins, Non-Histone; Histones; Humans; Lysine; Methylation; Molecular Conformation; Molecular Sequence Data; Nucleosomes; Polycomb-Group Proteins; Protein Conformation; Protein Processing, Post-Translational; Protein Structure, Tertiary; Repressor Proteins; Sequence Homology, Amino Acid | 2009 |
Analysis of arginine and lysine methylation utilizing peptide separations at neutral pH and electron transfer dissociation mass spectrometry.
Topics: Amino Acid Sequence; Animals; Arginine; Cattle; Cell Line; Chromatography, Reverse-Phase; HeLa Cells; Humans; Hydrogen-Ion Concentration; Lysine; Methylation; Molecular Sequence Data; Peptides; Proteins; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2010 |
Modification of integration site preferences of an HIV-1-based vector by expression of a novel synthetic protein.
Topics: Binding Sites; Blotting, Western; Cell Proliferation; Chromatin Immunoprecipitation; Chromobox Protein Homolog 5; Chromosomal Proteins, Non-Histone; Genetic Vectors; Green Fluorescent Proteins; Heterochromatin; Histones; HIV-1; Humans; Immunoenzyme Techniques; Immunoprecipitation; Intercellular Signaling Peptides and Proteins; Lentivirus; Lysine; Methylation; Recombinant Fusion Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Virus Integration; Virus Replication | 2010 |
H3K4 dimethylation in hepatocellular carcinoma is rare compared with other hepatobiliary and gastrointestinal carcinomas and correlates with expression of the methylase Ash2 and the demethylase LSD1.
Topics: Adult; Aged; Aged, 80 and over; Bile Duct Neoplasms; Bile Ducts, Extrahepatic; Bile Ducts, Intrahepatic; Carcinoma, Hepatocellular; Chi-Square Distribution; Cholangiocarcinoma; DNA-Binding Proteins; Female; Gastrointestinal Neoplasms; Histone Demethylases; Histones; Humans; Immunohistochemistry; Liver Neoplasms; Lysine; Male; Methylation; Middle Aged; Nuclear Proteins; Pancreatic Neoplasms; Transcription Factors | 2010 |
A conserved interaction between the SDI domain of Bre2 and the Dpy-30 domain of Sdc1 is required for histone methylation and gene expression.
Topics: Disulfides; DNA-Binding Proteins; Gene Expression Regulation, Fungal; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Nuclear Proteins; Protein Binding; Protein Multimerization; Protein Structure, Tertiary; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Transcription Factors | 2010 |
A homogeneous method for investigation of methylation-dependent protein-protein interactions in epigenetics.
Topics: Binding, Competitive; Chromobox Protein Homolog 5; Chromosomal Proteins, Non-Histone; Epigenesis, Genetic; Histones; Luminescent Measurements; Lysine; Methylation; Peptides; Phosphoproteins; Protein Interaction Domains and Motifs; Protein Interaction Mapping | 2010 |
A histone demethylase is necessary for regeneration in zebrafish.
Topics: Animals; Chromatin; Extremities; Histones; Homeodomain Proteins; Humans; Jumonji Domain-Containing Histone Demethylases; Lysine; Methylation; Oligonucleotides, Antisense; Promoter Regions, Genetic; Regeneration; Zebrafish; Zebrafish Proteins | 2009 |
Regulation of hippocampal H3 histone methylation by acute and chronic stress.
Topics: Acute Disease; Animals; Chronic Disease; Dentate Gyrus; Fluoxetine; Hippocampus; Histones; Lysine; Male; Methylation; Rats; Rats, Sprague-Dawley; Restraint, Physical; Stress, Psychological | 2009 |
A simple calixarene recognizes post-translationally methylated lysine.
Topics: Calixarenes; Chromobox Protein Homolog 5; Chromosomal Proteins, Non-Histone; Histones; Lysine; Magnetic Resonance Spectroscopy; Methylation; Protein Processing, Post-Translational; Thermodynamics | 2010 |
In vivo residue-specific histone methylation dynamics.
Topics: Arginine; Biochemistry; Chromatography, Liquid; Gene Silencing; HeLa Cells; Histones; Humans; Kinetics; Lysine; Mass Spectrometry; Methylation; Peptides; Protein Processing, Post-Translational; Proteomics | 2010 |
Histone H3K4 and K36 methylation, Chd1 and Rpd3S oppose the functions of Saccharomyces cerevisiae Spt4-Spt5 in transcription.
Topics: Acetylation; Chromatin; Chromosomal Proteins, Non-Histone; Conserved Sequence; DNA-Binding Proteins; Histone Deacetylases; Histones; Kinetics; Lysine; Methylation; Mutation; Nuclear Proteins; Nucleosomes; Protein Structure, Tertiary; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Transcription, Genetic; Transcriptional Elongation Factors | 2010 |
IVICAT for the masses: an improved technique for permethylation of peptides.
Topics: Acetylation; Biochemistry; Chromatography; Cryptosporidium; Histones; Hydrolysis; Lysine; Methylamines; Methylation; Models, Chemical; Peptides; Protein Structure, Tertiary; Proteomics; Toxoplasma | 2009 |
Carboxymethylation of the fibrillar collagen with respect to formation of hydroxyapatite.
Topics: Alkylation; Amino Acids; Biomimetics; Borohydrides; Collagen; Crystallization; Glucose; Glucuronic Acid; Glyoxylates; Hydroxyapatites; Indicators and Reagents; Lysine; Methylation; Microfibrils; Microscopy, Atomic Force; Microscopy, Electron, Scanning; Minerals; Spectroscopy, Fourier Transform Infrared | 2010 |
Screening for inhibitors of low-affinity epigenetic peptide-protein interactions: an AlphaScreen-based assay for antagonists of methyl-lysine binding proteins.
Topics: Automation; Binding, Competitive; Biological Assay; Buffers; Epigenesis, Genetic; Histones; Ligands; Lysine; Methylation; Miniaturization; Neoplasm Proteins; Peptides; Pilot Projects; Polysorbates; Protein Binding; Proteins; Small Molecule Libraries; Sodium Chloride; Time Factors; Titrimetry | 2010 |
Prenatal exposure to apoE deficiency and postnatal hypercholesterolemia are associated with altered cell-specific lysine methyltransferase and histone methylation patterns in the vasculature.
Topics: Animals; Animals, Newborn; Apolipoproteins E; Blood Vessels; Diet; Epigenesis, Genetic; Female; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Hypercholesterolemia; Lysine; Maternal Nutritional Physiological Phenomena; Methylation; Methyltransferases; Mice; Mice, Inbred C57BL; Mice, Transgenic; Organ Specificity; Pregnancy; Prenatal Exposure Delayed Effects | 2010 |
Reassessing the abundance of H3K9me2 chromatin domains in embryonic stem cells.
Topics: Animals; Cell Differentiation; Chromosome Mapping; Embryonic Stem Cells; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Mice; Protein Processing, Post-Translational | 2010 |
Histone H3 methylation at lysine 4 on the SLC2A5 gene in intestinal Caco-2 cells is involved in SLC2A5 expression.
Topics: Caco-2 Cells; Dexamethasone; Gene Expression Regulation; Glucose Transporter Type 5; Histones; Humans; Lysine; Methylation; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Protein Kinase Inhibitors | 2010 |
Ligand-specific regulation of the extracellular surface of a G-protein-coupled receptor.
Topics: Adrenergic beta-2 Receptor Agonists; Adrenergic beta-2 Receptor Antagonists; Allosteric Regulation; Binding Sites; Crystallography, X-Ray; Drug Inverse Agonism; Ethanolamines; Formoterol Fumarate; Humans; Ligands; Lysine; Methylation; Models, Molecular; Mutant Proteins; Nuclear Magnetic Resonance, Biomolecular; Propanolamines; Protein Structure, Tertiary; Receptors, Adrenergic, beta-2; Static Electricity; Substrate Specificity | 2010 |
Essential role of the histone methyltransferase G9a in cocaine-induced plasticity.
Topics: Animals; Behavior, Animal; Cocaine; Cocaine-Related Disorders; Dendritic Spines; Down-Regulation; Enzyme Repression; Gene Expression Profiling; Gene Expression Regulation; Histone-Lysine N-Methyltransferase; Histones; Lysine; Male; Methylation; Mice; Mice, Inbred C57BL; Neuronal Plasticity; Neurons; Nucleus Accumbens; Oligonucleotide Array Sequence Analysis; Proto-Oncogene Proteins c-fos; Reward; Self Administration; Transcription, Genetic | 2010 |
Phosphorylation of serine-10 of histone H3 shields modified lysine-9 selectively during mitosis.
Topics: Animals; Aurora Kinase B; Benzamides; Cell Cycle; Chromobox Protein Homolog 5; Chromosomal Proteins, Non-Histone; Female; Histones; Lysine; Male; Methylation; Mice; Mitosis; NIH 3T3 Cells; Phosphorylation; Protein Kinase Inhibitors; Quinazolines; Serine | 2010 |
KAP1 controls endogenous retroviruses in embryonic stem cells.
Topics: 5' Untranslated Regions; Acetylation; Animals; DNA Methylation; Embryo, Mammalian; Embryonic Stem Cells; Endogenous Retroviruses; Fibroblasts; Gene Silencing; Genes, Intracisternal A-Particle; Genes, Reporter; Green Fluorescent Proteins; Histones; Leukemia Virus, Murine; Lysine; Methylation; Mice; Nuclear Proteins; Promoter Regions, Genetic; Repressor Proteins; Tripartite Motif-Containing Protein 28 | 2010 |
Regulation of NF-kappaB by NSD1/FBXL11-dependent reversible lysine methylation of p65.
Topics: Amino Acid Sequence; Animals; Cell Line, Tumor; Cell Proliferation; Cells, Cultured; Cytokines; Embryo, Mammalian; F-Box Proteins; Fibroblasts; Gene Expression Regulation; Histone Demethylases; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Humans; Intracellular Signaling Peptides and Proteins; Jumonji Domain-Containing Histone Demethylases; Lysine; Methylation; Mice; Mice, Knockout; Molecular Sequence Data; Nuclear Proteins; Oxidoreductases, N-Demethylating; Protein Methyltransferases; Protein Subunits; Transcription Factor RelA | 2010 |
Regulation of HOXA2 gene expression by the ATP-dependent chromatin remodeling enzyme CHD8.
Topics: Adenosine Triphosphate; Blotting, Western; Cell Line, Tumor; Chromatin Assembly and Disassembly; Chromatin Immunoprecipitation; DNA-Binding Proteins; Gene Expression Regulation, Neoplastic; Histone-Lysine N-Methyltransferase; Histones; Homeodomain Proteins; Humans; Intracellular Signaling Peptides and Proteins; Lysine; Methylation; Myeloid-Lymphoid Leukemia Protein; Nuclear Proteins; Promoter Regions, Genetic; Protein Binding; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Transcription Factors; Tretinoin | 2010 |
Deregulation of H3K27 methylation in cancer.
Topics: DNA-Binding Proteins; Enhancer of Zeste Homolog 2 Protein; Germinal Center; Histones; Humans; Lymphoma, Follicular; Lymphoma, Large B-Cell, Diffuse; Lysine; Methylation; Mutation; Polycomb Repressive Complex 2; Transcription Factors | 2010 |
G9a and Glp methylate lysine 373 in the tumor suppressor p53.
Topics: Autoantigens; DNA Damage; DNA Methylation; Gene Expression Regulation; Golgi Matrix Proteins; Histocompatibility Antigens; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Humans; Lysine; Methylation; Neoplasms; Peptides; Protein Processing, Post-Translational; Proteins; Recombinant Proteins; RNA, Small Interfering; Tumor Suppressor Protein p53 | 2010 |
Enhanced crystal packing due to solvent reorganization through reductive methylation of lysine residues in oxidoreductase from Streptococcus pneumoniae.
Topics: Crystallization; Entropy; Hydrogen Bonding; Lysine; Methylation; Models, Molecular; Molecular Dynamics Simulation; Oxidoreductases; Protein Conformation; Solvents; Streptococcus pneumoniae; Thermodynamics | 2010 |
Identification of arginine- and lysine-methylation in the proteome of Saccharomyces cerevisiae and its functional implications.
Topics: Arginine; Computational Biology; Lysine; Methylation; Protein Interaction Domains and Motifs; Proteome; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2010 |
A nucleosome surface formed by histone H4, H2A, and H3 residues is needed for proper histone H3 Lys36 methylation, histone acetylation, and repression of cryptic transcription.
Topics: Acetylation; Chromatin Immunoprecipitation; Gene Expression Regulation, Fungal; Glutathione Transferase; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Leucine; Lysine; Methylation; Mutation; Plasmids; Saccharomyces cerevisiae; Transcription, Genetic | 2010 |
Lysine methylation regulates the pRb tumour suppressor protein.
Topics: Cell Cycle; Cell Differentiation; Cell Line, Tumor; Chromobox Protein Homolog 5; Chromosomal Proteins, Non-Histone; Humans; Lysine; Methylation; Retinoblastoma Protein | 2010 |
Replication and active demethylation represent partially overlapping mechanisms for erasure of H3K4me3 in budding yeast.
Topics: DNA Replication; Genome, Fungal; Histones; Jumonji Domain-Containing Histone Demethylases; Kinetics; Lysine; Mating Factor; Methylation; Nucleosomes; Peptides; S Phase; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Temperature | 2010 |
Genomic approaches uncover increasing complexities in the regulatory landscape at the human SCL (TAL1) locus.
Topics: Acetylation; Basic Helix-Loop-Helix Transcription Factors; Binding Sites; CCCTC-Binding Factor; Cell Line, Tumor; Chromatin Immunoprecipitation; Cluster Analysis; Gene Expression Regulation; Histones; HL-60 Cells; Humans; K562 Cells; Lysine; Methylation; Oligonucleotide Array Sequence Analysis; Promoter Regions, Genetic; Protein Binding; Proto-Oncogene Proteins; Regulatory Sequences, Nucleic Acid; Repressor Proteins; T-Cell Acute Lymphocytic Leukemia Protein 1; Transcription Factors; U937 Cells | 2010 |
Functional interplay between acetylation and methylation of the RelA subunit of NF-kappaB.
Topics: Acetylation; Amino Acid Sequence; Animals; Cell Line; Glutamine; Histone-Lysine N-Methyltransferase; Humans; Lysine; Methylation; Mice; Models, Biological; Models, Molecular; Molecular Sequence Data; Mutation; Promoter Regions, Genetic; Protein Binding; Protein Stability; Protein Structure, Tertiary; Protein Subunits; Transcription Factor RelA; Tumor Necrosis Factor-alpha; Ubiquitination | 2010 |
Histone H3 lysine 27 methylation asymmetry on developmentally-regulated promoters distinguish the first two lineages in mouse preimplantation embryos.
Topics: Animals; Blastocyst; Cell Lineage; Ectoderm; Embryonic Stem Cells; Female; Gene Expression Profiling; Gene Expression Regulation, Developmental; Histones; Lysine; Male; Methylation; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Oligonucleotide Array Sequence Analysis; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; Trophoblasts | 2010 |
Prognostic relevance of global histone H3 lysine 4 (H3K4) methylation in renal cell carcinoma.
Topics: Carcinoma, Renal Cell; Female; Histones; Humans; Immunohistochemistry; Kidney Neoplasms; Lysine; Male; Methylation; Middle Aged; Prognosis | 2010 |
A small molecule receptor that selectively recognizes trimethyl lysine in a histone peptide with native protein-like affinity.
Topics: Amino Acid Substitution; Combinatorial Chemistry Techniques; Histones; Lysine; Methylation; Mutagenesis, Site-Directed; Protein Processing, Post-Translational | 2010 |
Phosphorylation of histone H3T6 by PKCbeta(I) controls demethylation at histone H3K4.
Topics: Androgens; Animals; Cell Division; Cell Line, Tumor; Chromatin; Gene Expression Regulation; Gene Knockdown Techniques; Histone Demethylases; Histones; Humans; Lysine; Male; Methylation; Mice; Mice, Nude; Mice, SCID; Phosphorylation; Phosphothreonine; Promoter Regions, Genetic; Prostatic Neoplasms; Protein Kinase C; Protein Kinase C beta; Signal Transduction; Xenograft Model Antitumor Assays | 2010 |
Cohesion establishment factor, Eco1 represses transcription via association with histone demethylase, LSD1.
Topics: Acetyltransferases; Cell Line; Chromatin; Chromatin Immunoprecipitation; Gene Expression Regulation; Histone Deacetylase 1; Histone Deacetylase 2; Histone Demethylases; Humans; Lysine; Methylation; Repressor Proteins; Transcription, Genetic | 2010 |
Chromatin signature of embryonic pluripotency is established during genome activation.
Topics: Animals; Chromatin; Chromatin Immunoprecipitation; Gene Expression Regulation, Developmental; Gene Silencing; Genome; Histones; Lysine; Methylation; Oligonucleotide Array Sequence Analysis; Pluripotent Stem Cells; Promoter Regions, Genetic; RNA Polymerase II; Transcriptional Activation; Transgenes; Zebrafish; Zebrafish Proteins; Zygote | 2010 |
Chromatin states of developmentally-regulated genes revealed by DNA and histone methylation patterns in zebrafish embryos.
Topics: Animals; Blastula; Cell Line; Chromatin; Chromatin Immunoprecipitation; CpG Islands; DNA Methylation; Embryo, Nonmammalian; Fibroblasts; Gene Expression Profiling; Gene Expression Regulation, Developmental; Histones; In Situ Hybridization; Lysine; Methylation; Oligonucleotide Array Sequence Analysis; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; Zebrafish; Zebrafish Proteins | 2010 |
Enhanced protein detection using a trapping mode on a hybrid quadrupole linear ion trap (Q-Trap).
Topics: Animals; Cells, Cultured; Chickens; Chromatography, High Pressure Liquid; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Lysine; Mass Spectrometry; Methylation; Nanotechnology; Protein Processing, Post-Translational | 2009 |
Histone H3 trimethylated at lysine 4 is enriched at probable transcription start sites in Trypanosoma brucei.
Topics: Animals; Chromatin Immunoprecipitation; Gene Expression Regulation; Histones; Lysine; Methylation; Protein Binding; Transcription Initiation Site; Trypanosoma brucei brucei | 2010 |
Installation of site-specific methylation into histones using methyl lysine analogs.
Topics: Histones; Lysine; Methylation; Molecular Structure; Protein Processing, Post-Translational | 2010 |
SDG714 regulates specific gene expression and consequently affects plant growth via H3K9 dimethylation.
Topics: Arabidopsis; Blotting, Western; Chromatin Immunoprecipitation; Estradiol; Heterochromatin; Histones; Lysine; Methylation; Oligonucleotide Array Sequence Analysis; Oryza; Plant Proteins; Plants, Genetically Modified; Reverse Transcriptase Polymerase Chain Reaction | 2010 |
Characterization of an antagonistic switch between histone H3 lysine 27 methylation and acetylation in the transcriptional regulation of Polycomb group target genes.
Topics: Acetylation; Animals; Embryonic Stem Cells; Gene Expression Regulation; Gene Knockout Techniques; Histone Acetyltransferases; Histones; Lysine; Methylation; Mice; Polycomb Repressive Complex 2; Polycomb-Group Proteins; Repressor Proteins; Transcription, Genetic | 2010 |
Transcriptional activity affects the H3K4me3 level and distribution in the coding region.
Topics: Cell Line; Genes, Reporter; Histones; Humans; Lysine; Methylation; Models, Genetic; Open Reading Frames; Plasmids; Promoter Regions, Genetic; Transcription, Genetic | 2010 |
Histone H4 lysine 20 mono- and tri-methylation define distinct biological processes in SV40 minichromosomes.
Topics: Animals; Chromatin Immunoprecipitation; Chromosomes; DNA Replication; Lysine; Methylation; Simian virus 40 | 2010 |
LSD1-mediated demethylation of histone H3 lysine 4 triggers Myc-induced transcription.
Topics: Animals; Cell Line; Chromatin; DNA; DNA Repair Enzymes; E-Box Elements; Histone Demethylases; Histones; Lysine; Methylation; Mitogens; Oxidation-Reduction; Proto-Oncogene Proteins c-myc; Rats; Transcription, Genetic | 2010 |
A moonlighting function of Plasmodium falciparum histone 3, mono-methylated at lysine 9?
Topics: Cell Nucleus; Epigenesis, Genetic; Histones; Lysine; Methylation; Plasmodium falciparum; Vacuoles | 2010 |
PHF8 targets histone methylation and RNA polymerase II to activate transcription.
Topics: Amino Acid Sequence; Cell Line; Gene Expression Profiling; Gene Knockdown Techniques; Histone Demethylases; Histones; Humans; Lysine; Methylation; Microarray Analysis; Molecular Sequence Data; Recombinant Fusion Proteins; RNA Polymerase II; Transcription Factors | 2010 |
Developmental regulation and individual differences of neuronal H3K4me3 epigenomes in the prefrontal cortex.
Topics: Adolescent; Adult; Aged; Antigens, Nuclear; Cell Count; Child; Child, Preschool; Chromatin Assembly and Disassembly; Epigenesis, Genetic; Gene Expression Profiling; Gene Expression Regulation, Developmental; Genome; Histones; Humans; Infant; Lysine; Methylation; Middle Aged; Nerve Tissue Proteins; Neurons; Prefrontal Cortex; RNA, Messenger; Young Adult | 2010 |
ODDSOC2 is a MADS box floral repressor that is down-regulated by vernalization in temperate cereals.
Topics: Arabidopsis Proteins; Climate; Cold Temperature; Down-Regulation; Edible Grain; Flowers; Gene Expression Regulation, Plant; Genes, Plant; Histones; Hordeum; Lysine; MADS Domain Proteins; Methylation; Models, Genetic; Molecular Sequence Data; Phenotype; Photoperiod; Plant Leaves; Plant Proteins; Plant Stems; Promoter Regions, Genetic; Repressor Proteins; Sequence Homology, Amino Acid | 2010 |
Nuclear profiles of H3 histones trimethylated on Lys27 in bovine (Bos taurus) embryos obtained after in vitro fertilization or somatic cell nuclear transfer.
Topics: Animals; Cattle; Cell Nucleus; Cells, Cultured; Chromatin Assembly and Disassembly; Embryo, Mammalian; Embryonic Development; Female; Fertilization in Vitro; Heterochromatin; Histones; Hybrid Cells; Lysine; Male; Metabolome; Methylation; Mice; Nuclear Transfer Techniques; Pregnancy | 2010 |
Mapping of lysine methylation and acetylation in core histones of Neurospora crassa.
Topics: Acetylation; Amino Acid Sequence; Chromatography, High Pressure Liquid; Histones; Lysine; Methylation; Neurospora crassa; Spectrometry, Mass, Electrospray Ionization; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2010 |
Histone H2B C-terminal helix mediates trans-histone H3K4 methylation independent of H2B ubiquitination.
Topics: Amino Acid Sequence; Chromatin; DNA-Binding Proteins; Gene Expression Regulation, Fungal; Gene Silencing; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Models, Molecular; Molecular Sequence Data; Mutation; Protein Conformation; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Telomere; Ubiquitination | 2010 |
Methylation of ribosomal protein L42 regulates ribosomal function and stress-adapted cell growth.
Topics: Adaptation, Physiological; Amino Acid Sequence; Cell Line; Cell Nucleus; Cell Proliferation; Chromatography, Liquid; Cold Temperature; Conserved Sequence; Cycloheximide; Humans; Lysine; Mass Spectrometry; Methylation; Methyltransferases; Molecular Sequence Data; Mutation; Protein Transport; Recombinant Proteins; Ribosomal Proteins; Ribosome Subunits, Large, Eukaryotic; Ribosomes; Schizosaccharomyces; Schizosaccharomyces pombe Proteins; Stress, Physiological; Time Factors | 2010 |
Binding of the MLL PHD3 finger to histone H3K4me3 is required for MLL-dependent gene transcription.
Topics: Amino Acid Sequence; Animals; Cattle; Cell Line; Gene Expression Regulation; Histones; Humans; Lysine; Methylation; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Myeloid-Lymphoid Leukemia Protein; Nuclear Magnetic Resonance, Biomolecular; Protein Binding; Protein Structure, Secondary; Protein Structure, Tertiary; Proto-Oncogene Mas; Recombinant Fusion Proteins; Sequence Alignment; Transcription, Genetic | 2010 |
JIL-1 and Su(var)3-7 interact genetically and counteract each other's effect on position-effect variegation in Drosophila.
Topics: Animals; Animals, Genetically Modified; Chromosomal Position Effects; Chromosomes, Insect; DNA-Binding Proteins; Drosophila melanogaster; Drosophila Proteins; Epistasis, Genetic; Female; Green Fluorescent Proteins; Histones; Immunohistochemistry; Lysine; Male; Methylation; Methyltransferases; Microscopy, Fluorescence; Mutation; Protein Serine-Threonine Kinases | 2010 |
Widespread remodeling of mid-coding sequence nucleosomes by Isw1.
Topics: Adenosine Triphosphatases; Base Sequence; Chromatin Assembly and Disassembly; Chromosome Positioning; DNA-Binding Proteins; Gene Deletion; Gene Expression Regulation, Fungal; Histones; Lysine; Methylation; Models, Genetic; Nucleosomes; Open Reading Frames; RNA Polymerase II; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Species Specificity; Transcription Initiation Site | 2010 |
The Arabidopsis Paf1c complex component CDC73 participates in the modification of FLOWERING LOCUS C chromatin.
Topics: Arabidopsis; Arabidopsis Proteins; Chromatin; Chromatin Immunoprecipitation; Flowers; Gene Expression Regulation, Plant; Genes, Plant; Genetic Loci; Histones; Lysine; MADS Domain Proteins; Methylation; Mutation; Phenotype; Sequence Homology, Amino Acid; Up-Regulation | 2010 |
cis-Regulatory elements and chromatin state coordinately control temporal and spatial expression of FLOWERING LOCUS T in Arabidopsis.
Topics: Arabidopsis; Arabidopsis Proteins; Base Pairing; Base Sequence; Chromatin; Chromosomal Proteins, Non-Histone; Chromosome Mapping; DNA-Binding Proteins; Gene Expression Regulation, Plant; Genetic Loci; Histones; Lysine; Methylation; Models, Genetic; Molecular Sequence Data; Photoperiod; Phylogeny; Promoter Regions, Genetic; Protein Biosynthesis; Time Factors; Transcription Factors; Transcription, Genetic; Transcriptional Activation | 2010 |
ETS transcription factors control transcription of EZH2 and epigenetic silencing of the tumor suppressor gene Nkx3.1 in prostate cancer.
Topics: Aged; Anoikis; Cell Movement; DNA-Binding Proteins; Enhancer of Zeste Homolog 2 Protein; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Gene Silencing; Histones; Homeodomain Proteins; Humans; Lysine; Male; Methylation; Middle Aged; Models, Genetic; Polycomb Repressive Complex 2; Prostatic Neoplasms; Proto-Oncogene Proteins c-ets; Trans-Activators; Transcription Factors; Transcription, Genetic; Transcriptional Regulator ERG; Tumor Suppressor Proteins; Up-Regulation | 2010 |
Top-down analysis of recombinant histone H3 and its methylated analogs by ESI/FT-ICR mass spectrometry.
Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Histones; Lysine; Methylation; Molecular Sequence Data; Molecular Weight; Recombinant Proteins; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Spectroscopy, Fourier Transform Infrared; Xenopus laevis | 2010 |
Phosphorylation of the chromodomain changes the binding specificity of Cbx2 for methylated histone H3.
Topics: Amino Acid Sequence; Animals; Histones; Lysine; Male; Methylation; Mice; Mice, Inbred C57BL; Molecular Sequence Data; NIH 3T3 Cells; Phosphorylation; Polycomb Repressive Complex 1; Polycomb-Group Proteins; Protein Structure, Tertiary; Repressor Proteins | 2010 |
Histone methylation is a critical regulator of the abnormal expression of POU5F1 and RASSF1A in testis cancer cell lines.
Topics: Azacitidine; Decitabine; Gene Silencing; Histones; Humans; Lysine; Male; Methylation; Octamer Transcription Factor-3; Proto-Oncogene Mas; Testicular Neoplasms; Tumor Suppressor Proteins | 2011 |
Profiling of histone H3 lysine 9 trimethylation levels predicts transcription factor activity and survival in acute myeloid leukemia.
Topics: Adolescent; Antigens, CD34; Child; Child, Preschool; Disease-Free Survival; Female; Gene Expression Regulation, Leukemic; Hematopoietic Stem Cells; Histones; Humans; Infant; Leukemia, Myeloid, Acute; Lysine; Male; Methylation; Prognosis; Promoter Regions, Genetic; Protein Binding; Transcription Factors; Tumor Cells, Cultured | 2010 |
New surface contacts formed upon reductive lysine methylation: improving the probability of protein crystallization.
Topics: Crystallization; Databases, Protein; Isoelectric Point; Lysine; Methylation; Proteins; Surface Properties; Thermodynamics | 2010 |
Two novel methyltransferases acting upon eukaryotic elongation factor 1A in Saccharomyces cerevisiae.
Topics: Amino Acid Sequence; Binding Sites; Conserved Sequence; Gene Deletion; Genes, Fungal; Lysine; Methylation; Methyltransferases; Molecular Sequence Data; Peptide Elongation Factor 1; Protein Methyltransferases; Protein Processing, Post-Translational; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sequence Homology, Amino Acid | 2010 |
Integrative epigenomic and genomic analysis of malignant pheochromocytoma.
Topics: Adrenal Gland Neoplasms; Epigenesis, Genetic; Female; Gene Dosage; Gene Expression Regulation, Neoplastic; Gene Regulatory Networks; Genome, Human; Genomics; Histones; Humans; Lysine; Methylation; Pheochromocytoma; Protein Processing, Post-Translational; Tumor Suppressor Proteins | 2010 |
Dueling post-translational modifications trigger folding and unfolding of a beta-hairpin peptide.
Topics: Animals; Cattle; Cyclic AMP-Dependent Protein Kinases; Lysine; Methylation; Peptides; Phosphorylation; Phosphoserine; Protein Denaturation; Protein Folding; Protein Processing, Post-Translational; Protein Stability; Protein Structure, Secondary | 2010 |
The interaction of modified histones with the bromodomain testis-specific (BRDT) gene and its mRNA level in sperm of fertile donors and subfertile men.
Topics: Acetylation; Case-Control Studies; Chromatin Assembly and Disassembly; Chromatin Immunoprecipitation; Exons; Fertility; Germany; Histones; Humans; Infertility, Male; Lysine; Male; Methylation; Nuclear Proteins; Polymerase Chain Reaction; Promoter Regions, Genetic; Protein Processing, Post-Translational; RNA, Messenger; Spermatozoa; Up-Regulation | 2010 |
Molecular interplay of the noncoding RNA ANRIL and methylated histone H3 lysine 27 by polycomb CBX7 in transcriptional silencing of INK4a.
Topics: Animals; Cell Line, Tumor; Cellular Senescence; Cyclin-Dependent Kinase Inhibitor p15; Cyclin-Dependent Kinase Inhibitor p16; Gene Silencing; Histones; Humans; Lysine; Male; Methylation; Models, Molecular; Molecular Sequence Data; Multigene Family; Nuclear Magnetic Resonance, Biomolecular; Polycomb Repressive Complex 1; Polycomb-Group Proteins; Prostatic Neoplasms; Protein Structure, Tertiary; Repressor Proteins; RNA, Untranslated; Transcription, Genetic | 2010 |
The polycomb group protein BMI1 is a transcriptional target of HDAC inhibitors.
Topics: Apoptosis; Breast; Cell Line, Tumor; Cellular Senescence; DNA-Binding Proteins; Down-Regulation; Enhancer of Zeste Homolog 2 Protein; Epithelial Cells; Female; Histone Deacetylase Inhibitors; Histones; Humans; Lysine; Methylation; Nuclear Proteins; Polycomb Repressive Complex 1; Polycomb Repressive Complex 2; Polycomb-Group Proteins; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-myc; Repressor Proteins; Transcription Factors; Transcription, Genetic; Ubiquitination | 2010 |
The Dnmt3a PWWP domain reads histone 3 lysine 36 trimethylation and guides DNA methylation.
Topics: Animals; Cell Line; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Methyltransferase 3A; Histones; Humans; Lysine; Methylation; Mice; Protein Array Analysis; Protein Binding; Protein Structure, Tertiary; Transfection | 2010 |
Members of the H3K4 trimethylation complex regulate lifespan in a germline-dependent manner in C. elegans.
Topics: Animals; Animals, Genetically Modified; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Disorders of Sex Development; Epigenesis, Genetic; Gene Expression Regulation; Gene Knockdown Techniques; Germ Cells; Histone Demethylases; Histone-Lysine N-Methyltransferase; Histones; Longevity; Lysine; Male; Methylation; Multiprotein Complexes; Nuclear Proteins; Retinoblastoma-Binding Protein 2; RNA Interference | 2010 |
Inhibition of histone deacetylase 3 produces mitotic defects independent of alterations in histone H3 lysine 9 acetylation and methylation.
Topics: Acetylation; Animals; Cell Line, Tumor; Chromobox Protein Homolog 5; Chromosomal Proteins, Non-Histone; Drosophila melanogaster; Embryo, Nonmammalian; Female; HeLa Cells; Heterochromatin; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Humans; Lysine; Methylation; Mitosis; Protein Processing, Post-Translational | 2010 |
Active loss of DNA methylation in two-cell stage goat embryos.
Topics: 5-Methylcytosine; Animals; Azacitidine; Decitabine; DNA; DNA Methylation; DNA Modification Methylases; Embryo, Mammalian; Enzyme Inhibitors; Female; Goats; Histones; Immunohistochemistry; Lysine; Male; Methylation; Zygote | 2010 |
Small-molecule-based inhibition of histone demethylation in cells assessed by quantitative mass spectrometry.
Topics: Cell Line; Chromatography, Liquid; Gene Expression Regulation; Histone Demethylases; Histones; Humans; Immunoblotting; Jumonji Domain-Containing Histone Demethylases; Lysine; Mass Spectrometry; Methylation; Protein Processing, Post-Translational; Proteomics; Pyridines | 2010 |
Silencing of integrated human papillomavirus-16 oncogenes by small interfering RNA-mediated heterochromatization.
Topics: Apoptosis; Base Sequence; Binding Sites; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Chromatin; Enhancer Elements, Genetic; HeLa Cells; Heterochromatin; Histones; Human papillomavirus 16; Humans; Lysine; Methylation; Neurofibromin 1; Oncogene Proteins, Viral; Papillomavirus E7 Proteins; Repressor Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; RNA, Small Interfering; Transcription, Genetic; Transfection; Tumor Suppressor Protein p53 | 2010 |
MDM2 recruitment of lysine methyltransferases regulates p53 transcriptional output.
Topics: Animals; Cells, Cultured; Gene Expression Regulation; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Methyltransferases; Mice; Promoter Regions, Genetic; Protein Binding; Proto-Oncogene Proteins c-mdm2; Repressor Proteins; Stress, Physiological; Transcription, Genetic; Tumor Suppressor Protein p53 | 2010 |
Chromatin protein L3MBTL1 is dispensable for development and tumor suppression in mice.
Topics: Amino Acid Sequence; Animals; Base Sequence; Brain; Cell Cycle; Chromatin; Cyclin E; Gene Expression Regulation; Gene Knockout Techniques; Growth and Development; HeLa Cells; Histones; Humans; Longevity; Lymphopoiesis; Lysine; Male; Methylation; Mice; Molecular Sequence Data; Neoplasms; Nuclear Proteins; Repressor Proteins; Survival Rate; Tumor Suppressor Proteins | 2010 |
Negative regulation of hypoxic responses via induced Reptin methylation.
Topics: Animals; ATPases Associated with Diverse Cellular Activities; Carrier Proteins; Cell Hypoxia; Cell Line; DNA Helicases; Female; Gene Expression Regulation, Neoplastic; Histocompatibility Antigens; Histone-Lysine N-Methyltransferase; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Lysine; Methylation; Mice; Models, Biological; Neoplasms; Oligonucleotide Array Sequence Analysis; Promoter Regions, Genetic; Protein Binding; Xenograft Model Antitumor Assays | 2010 |
Lysine methylation regulates E2F1-induced cell death.
Topics: Acetylation; Cell Death; Cell Line, Tumor; DNA Damage; E2F1 Transcription Factor; Histone Demethylases; Histone-Lysine N-Methyltransferase; Humans; Lysine; Methylation; Phosphorylation; Protein Stability; Tumor Suppressor Protein p53; Ubiquitination | 2010 |
Differentiation of neural-crest-derived intermediate pluripotent progenitors into committed periodontal populations involves unique molecular signature changes, cohort shifts, and epigenetic modifications.
Topics: Adolescent; Calcification, Physiologic; Cell Differentiation; Cell Lineage; Cell Shape; Child; Dental Cementum; Dental Sac; Epigenesis, Genetic; Extracellular Matrix; Gene Expression Profiling; Gene Expression Regulation; Histones; Humans; Lysine; Methylation; Neural Crest; Osteoblasts; Osteogenesis; Periodontal Ligament; Periodontium; Pluripotent Stem Cells | 2011 |
Characterization of HIV Tat modifications using novel methyl-lysine-specific antibodies.
Topics: Amino Acid Sequence; Animals; Antibodies; Blotting, Western; HEK293 Cells; HIV-1; Humans; Immunoblotting; Lysine; Methylation; Protein Processing, Post-Translational; Rabbits; tat Gene Products, Human Immunodeficiency Virus; Transfection | 2011 |
Global relevance of Aire binding to hypomethylated lysine-4 of histone-3.
Topics: AIRE Protein; Animals; Cells, Cultured; Epithelial Cells; Gene Expression Regulation; Histones; Immune Tolerance; Lysine; Methylation; Mice; Mice, Transgenic; Mutation; Oxidoreductases, O-Demethylating; Protein Binding; Protein Structure, Tertiary; RNA, Messenger; Substrate Specificity; Thymus Gland; Transcription Factors; Transcription, Genetic | 2010 |
Lysine N(epsilon)-trimethylation, a tool for improving the selectivity of antimicrobial peptides.
Topics: Amino Acid Sequence; Anti-Bacterial Agents; Anti-Infective Agents; Antimicrobial Cationic Peptides; Gram-Negative Bacteria; Gram-Positive Bacteria; Hemolysis; Leishmania; Lysine; Methylation; Models, Molecular; Molecular Conformation; Molecular Sequence Data; Structure-Activity Relationship; Trypanocidal Agents | 2010 |
Histone H4K20/H3K9 demethylase PHF8 regulates zebrafish brain and craniofacial development.
Topics: Animals; Biocatalysis; Brain; Catalytic Domain; Cell Cycle; Cell Line, Tumor; Cell Survival; DNA, Intergenic; Gene Expression Regulation; Head; Histone Demethylases; Histones; Homeodomain Proteins; Humans; Jaw; Lysine; Mental Retardation, X-Linked; Methylation; Neurons; Promoter Regions, Genetic; Transcription Factors; Transcription Initiation Site; Zebrafish; Zebrafish Proteins | 2010 |
PHF8 mediates histone H4 lysine 20 demethylation events involved in cell cycle progression.
Topics: Adenosine Triphosphatases; Cell Cycle; Cell Line; Chromatin; Chromosomal Proteins, Non-Histone; DNA-Binding Proteins; HeLa Cells; Histone Demethylases; Histone-Lysine N-Methyltransferase; Histones; Host Cell Factor C1; Humans; Lysine; Methylation; Multiprotein Complexes; Phosphorylation; Promoter Regions, Genetic; Protein Structure, Tertiary; Transcription Factors | 2010 |
A simple method for gene expression and chromatin profiling of individual cell types within a tissue.
Topics: Arabidopsis; Arabidopsis Proteins; Biotin; Cell Differentiation; Chromatin; Gene Expression Profiling; Gene Expression Regulation, Developmental; Gene Expression Regulation, Plant; Histones; Lysine; Methylation; Models, Genetic; Molecular Biology; Nuclear Proteins; Plant Epidermis; Plant Roots; RNA; Staining and Labeling | 2010 |
KIAA1718 is a histone demethylase that erases repressive histone methyl marks.
Topics: Animals; Cells, Cultured; Histone Demethylases; Histones; Humans; Lysine; Methylation; Mice | 2010 |
Regulation of heterochromatic DNA replication by histone H3 lysine 27 methyltransferases.
Topics: Amino Acid Motifs; Arabidopsis; Arabidopsis Proteins; Catalytic Domain; DNA Methylation; DNA Replication; DNA Transposable Elements; DNA, Plant; Gene Expression Regulation, Plant; Gene Silencing; Genome, Plant; Heterochromatin; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Methyltransferases; Mutant Proteins; Mutation; Replication Origin | 2010 |
Application of machine learning methods to histone methylation ChIP-Seq data reveals H4R3me2 globally represses gene expression.
Topics: Arginine; Artificial Intelligence; Base Sequence; CD4-Positive T-Lymphocytes; Epigenesis, Genetic; Gene Expression; Histones; Humans; Lysine; Methylation; Oligonucleotide Array Sequence Analysis; Protein Methyltransferases; Protein Processing, Post-Translational | 2010 |
Corecognition of DNA and a methylated histone tail by the MSL3 chromodomain.
Topics: Animals; DNA; Drosophila melanogaster; Drosophila Proteins; Histones; Lysine; Methylation; Models, Molecular; Peptides; Protein Structure, Secondary; Protein Structure, Tertiary; Protein Subunits; Substrate Specificity | 2010 |
Dynamic patterns of histone lysine methylation in the developing retina.
Topics: Animals; Apoptosis; Biomarkers; Blotting, Western; Cell Differentiation; Cells, Cultured; Enhancer of Zeste Homolog 2 Protein; Histone-Lysine N-Methyltransferase; Histones; Immunohistochemistry; Lysine; Methylation; Mice; Microscopy, Confocal; Microscopy, Fluorescence; Polycomb Repressive Complex 2; Retina; Retinal Ganglion Cells | 2010 |
SET7/9 catalytic mutants reveal the role of active site water molecules in lysine multiple methylation.
Topics: Amino Acid Substitution; Catalysis; Catalytic Domain; Crystallography, X-Ray; Histone-Lysine N-Methyltransferase; Humans; Lysine; Methylation; Mutation, Missense; Water | 2010 |
Heterochromatin formation in the mouse embryo requires critical residues of the histone variant H3.3.
Topics: Amino Acid Substitution; Animals; Blastocyst; Chromatin; Chromosomal Proteins, Non-Histone; Chromosome Segregation; DNA, Satellite; Embryo, Mammalian; Embryonic Development; Epigenesis, Genetic; Female; Genetic Variation; Heterochromatin; Histones; Lysine; Male; Methylation; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Recombinant Fusion Proteins; RNA, Double-Stranded; RNA, Messenger; Time Factors; Zygote | 2010 |
A lysine-rich region in Dot1p is crucial for direct interaction with H2B ubiquitylation and high level methylation of H3K79.
Topics: Gene Silencing; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Nuclear Proteins; Nucleosomes; Point Mutation; Saccharomyces cerevisiae Proteins; Sequence Deletion; Ubiquitin; Ubiquitination | 2010 |
Requirement for the phospho-H2AX binding module of Crb2 in double-strand break targeting and checkpoint activation.
Topics: Binding Sites; Blotting, Western; Cell Cycle; Cell Cycle Proteins; Chromatin; DNA Breaks, Double-Stranded; DNA Damage; DNA Repair; Histones; Lysine; Methylation; Mutation; Nuclear Proteins; Phosphoproteins; Phosphorylation; Protein Binding; Schizosaccharomyces; Schizosaccharomyces pombe Proteins; Threonine | 2010 |
Overexpression of EZH2 contributes to acquired cisplatin resistance in ovarian cancer cells in vitro and in vivo.
Topics: Animals; Antineoplastic Agents; Blotting, Western; Cell Line, Tumor; Cell Survival; Cisplatin; DNA-Binding Proteins; Dose-Response Relationship, Drug; Drug Resistance, Neoplasm; Enhancer of Zeste Homolog 2 Protein; Female; Gene Expression Regulation, Neoplastic; Histones; Humans; Lysine; Methylation; Mice; Mice, Inbred BALB C; Mice, Nude; Ovarian Neoplasms; Polycomb Repressive Complex 2; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Transcription Factors; Tumor Burden; Xenograft Model Antitumor Assays | 2010 |
Defining the epigenetic actions of growth hormone: acute chromatin changes accompany GH-activated gene transcription.
Topics: Animals; Chromatin; Epigenesis, Genetic; Growth Hormone; Histones; Humans; Lysine; Male; Methylation; Promoter Regions, Genetic; Proto-Oncogene Proteins c-bcl-6; Rats; Rats, Sprague-Dawley; STAT5 Transcription Factor; Transcription, Genetic | 2010 |
MLL2 is required in oocytes for bulk histone 3 lysine 4 trimethylation and transcriptional silencing.
Topics: Animals; Epigenomics; Female; Gene Expression Regulation, Developmental; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Methyltransferases; Mice; Mice, Inbred C57BL; Mice, Knockout; Myeloid-Lymphoid Leukemia Protein; Oocytes; Oogenesis | 2010 |
Extensive lysine methylation in hyperthermophilic crenarchaea: potential implications for protein stability and recombinant enzymes.
Topics: Archaeal Proteins; Biotechnology; DNA-Directed RNA Polymerases; Lysine; Methylation; Models, Molecular; Protein Methyltransferases; Protein Stability; Protein Structure, Quaternary; Protein Structure, Tertiary; Recombinant Proteins; Substrate Specificity; Sulfolobus solfataricus; Thermoproteus | 2010 |
FK228 induces mitotic catastrophe in A549 cells by mistargeting chromosomal passenger complex localization through changing centromeric H3K9 hypoacetylation.
Topics: Acetylation; Antibiotics, Antineoplastic; Autoantigens; Blotting, Western; Cell Line, Tumor; Cell Survival; Centromere; Centromere Protein A; Chromosomal Proteins, Non-Histone; Depsipeptides; Histones; Humans; Lysine; Methylation; Microscopy, Fluorescence; Mitosis; Phosphorylation; Serine; Spindle Apparatus; Time Factors | 2010 |
Phosphorylation of MLL by ATR is required for execution of mammalian S-phase checkpoint.
Topics: Alleles; Animals; Ataxia Telangiectasia Mutated Proteins; Cell Cycle Proteins; Cell Line; Chromatin; DNA Damage; DNA Replication; Genes, Dominant; Genomic Instability; Histone-Lysine N-Methyltransferase; Histones; Humans; Leukemia; Lysine; Methylation; Mice; Myeloid Progenitor Cells; Myeloid-Lymphoid Leukemia Protein; Phosphorylation; Phosphoserine; Protein Binding; Protein Serine-Threonine Kinases; S Phase; S-Phase Kinase-Associated Proteins; Signal Transduction; Translocation, Genetic | 2010 |
The histone H3K36 methyltransferase MES-4 acts epigenetically to transmit the memory of germline gene expression to progeny.
Topics: Animals; Binding Sites; Biocatalysis; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Embryo, Nonmammalian; Epigenesis, Genetic; Female; Gene Expression Regulation, Developmental; Genes, Helminth; Germ Cells; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Open Reading Frames; Protein Binding; RNA Interference; RNA Polymerase II; X Chromosome | 2010 |
Systematic identification of methyllysine-driven interactions for histone and nonhistone targets.
Topics: Chromobox Protein Homolog 5; Epigenomics; Histones; Humans; Lysine; Methylation; Protein Array Analysis; Protein Binding; Tumor Suppressor Protein p53 | 2010 |
The Plant Homeo Domain finger protein, VIN3-LIKE 2, is necessary for photoperiod-mediated epigenetic regulation of the floral repressor, MAF5.
Topics: Arabidopsis; Arabidopsis Proteins; Chromatin; Epigenesis, Genetic; Flowers; Gene Expression Regulation, Plant; Histones; Homeodomain Proteins; Lysine; Methylation; Photoperiod; Repressor Proteins | 2010 |
Role for the nuclear receptor-binding SET domain protein 1 (NSD1) methyltransferase in coordinating lysine 36 methylation at histone 3 with RNA polymerase II function.
Topics: Bone Morphogenetic Protein 4; Butyrate Response Factor 1; Gene Expression Regulation; Gene Knockdown Techniques; Gene Regulatory Networks; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; Intracellular Signaling Peptides and Proteins; Lysine; Methylation; Methyltransferases; Nuclear Proteins; Promoter Regions, Genetic; RNA Polymerase II | 2010 |
Ornithine decarboxylase antizyme induces hypomethylation of genome DNA and histone H3 lysine 9 dimethylation (H3K9me2) in human oral cancer cell line.
Topics: Cell Line, Tumor; DNA; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Methyltransferase 3B; Histones; Humans; Lysine; Methylation; Mouth Neoplasms; Proteins | 2010 |
Quantitative interaction proteomics and genome-wide profiling of epigenetic histone marks and their readers.
Topics: Chromatin; Epigenesis, Genetic; Gene Expression Regulation; Genome-Wide Association Study; HeLa Cells; Histone Acetyltransferases; Histone Code; Humans; Lysine; Mass Spectrometry; Methylation; Proteomics | 2010 |
In situ chemical modification of peptide microarrays: application to the study of the antibody responses to methylated antigens.
Topics: Alkylation; Amines; Amino Acid Sequence; Animals; Antibodies; Bacterial Proteins; Borohydrides; Formaldehyde; Glass; Lectins; Lysine; Methylation; Mice; Microscopy; Molecular Sequence Data; Mycobacterium tuberculosis; Nickel; Peptide Fragments; Printing; Protein Array Analysis | 2010 |
Polycomb group protein displacement and gene activation through MSK-dependent H3K27me3S28 phosphorylation.
Topics: Activating Transcription Factor 3; Anisomycin; Antibodies; Cell Differentiation; Cell Line, Tumor; Chromatin; DNA Damage; Embryonic Stem Cells; Fibroblasts; Gene Expression; Gene Expression Regulation; HeLa Cells; Histones; Humans; Lysine; Methylation; Mitosis; Neurons; Peptides; Phosphorylation; Polycomb-Group Proteins; Promoter Regions, Genetic; Protein Binding; Protein Transport; Repressor Proteins; Ribosomal Protein S6 Kinases, 90-kDa; Serine | 2010 |
The MBT repeats of L3MBTL1 link SET8-mediated p53 methylation at lysine 382 to target gene repression.
Topics: Amino Acid Sequence; Apoptosis Regulatory Proteins; Cell Line; Chromosomal Proteins, Non-Histone; Cyclin-Dependent Kinase Inhibitor p21; Gene Expression Regulation; Histone-Lysine N-Methyltransferase; Humans; Lysine; Methylation; Neoplasm Proteins; Protein Binding; Protein Structure, Tertiary; Proto-Oncogene Proteins; Repressor Proteins; Tumor Suppressor Protein p53; Tumor Suppressor Proteins | 2010 |
Cell-specific occupancy of an extended repertoire of CREM and CREB binding loci in male germ cells.
Topics: Animals; Binding Sites; Cell Line; Chromatin Immunoprecipitation; Chromosomes, Mammalian; Cyclic AMP Response Element Modulator; Cyclic AMP Response Element-Binding Protein; Gene Expression Regulation; Genetic Loci; Haploidy; Histones; Lysine; Male; Methylation; Mice; MicroRNAs; Organ Specificity; Promoter Regions, Genetic; RNA, Messenger; Spermatids; Spermatozoa; Testis | 2010 |
Promoter-exon relationship of H3 lysine 9, 27, 36 and 79 methylation on pluripotency-associated genes.
Topics: Cell Line, Tumor; Exons; Gene Expression Regulation; Histones; Homeodomain Proteins; Humans; Lysine; Methylation; Nanog Homeobox Protein; Octamer Transcription Factor-3; Pluripotent Stem Cells; Promoter Regions, Genetic; SOXB1 Transcription Factors | 2010 |
Influence of lysine N(ε)-trimethylation and lipid composition on the membrane activity of the cecropin A-melittin hybrid peptide CA(1-7)M(2-9).
Topics: Amino Acid Sequence; Antimicrobial Cationic Peptides; Calorimetry, Differential Scanning; Lipids; Liposomes; Lysine; Methylation; Molecular Sequence Data; Thermodynamics | 2010 |
H3K27me3 profiling of the endosperm implies exclusion of polycomb group protein targeting by DNA methylation.
Topics: Arabidopsis; Arabidopsis Proteins; Cluster Analysis; DNA Methylation; DNA Transposable Elements; Endosperm; Flow Cytometry; Gene Expression Profiling; Gene Expression Regulation, Plant; Genome, Plant; Green Fluorescent Proteins; Histones; Lysine; Methylation; Microscopy, Fluorescence; Mutation; Oligonucleotide Array Sequence Analysis; Plants, Genetically Modified; Polycomb-Group Proteins; Repressor Proteins; Reverse Transcriptase Polymerase Chain Reaction; Transcription Factors | 2010 |
Epigenetic antagonism between polycomb and SWI/SNF complexes during oncogenic transformation.
Topics: Animals; Cell Line, Tumor; Cell Lineage; Cell Proliferation; Cell Transformation, Neoplastic; Chromosomal Proteins, Non-Histone; Cyclin-Dependent Kinase Inhibitor p16; Embryo, Mammalian; Enhancer of Zeste Homolog 2 Protein; Epigenesis, Genetic; Fibroblasts; Gene Silencing; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Mice; Models, Genetic; Polycomb Repressive Complex 2; Polycomb-Group Proteins; Repressor Proteins; SMARCB1 Protein; Stem Cells; T-Lymphocytes; Transcription, Genetic; Up-Regulation | 2010 |
Regulation of the androgen receptor by SET9-mediated methylation.
Topics: Active Transport, Cell Nucleus; Cell Line, Tumor; Cell Nucleus; Cell Proliferation; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Male; Methylation; Prostate-Specific Antigen; Prostatic Neoplasms; Receptors, Androgen; Transcriptional Activation | 2011 |
Calmodulin methyltransferase is an evolutionarily conserved enzyme that trimethylates Lys-115 in calmodulin.
Topics: Amino Acid Sequence; Animals; Calmodulin; Chromatography, Liquid; Chromatography, Thin Layer; Electrophoresis, Polyacrylamide Gel; Humans; Insect Proteins; Lysine; Methylation; Methyltransferases; Molecular Sequence Data; Plant Proteins; Protein Processing, Post-Translational; Protein Structure, Secondary; Rats; Sequence Homology, Amino Acid; Tandem Mass Spectrometry | 2010 |
Epigenetically deregulated microRNA-375 is involved in a positive feedback loop with estrogen receptor alpha in breast cancer cells.
Topics: Base Sequence; Binding Sites; Breast Neoplasms; CCCTC-Binding Factor; Cell Line; Cell Line, Tumor; Cell Proliferation; CpG Islands; DNA Methylation; Epigenesis, Genetic; Estrogen Receptor alpha; Feedback, Physiological; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; HEK293 Cells; Histones; Humans; Immunoblotting; Lysine; Methylation; MicroRNAs; Molecular Sequence Data; Oligonucleotide Array Sequence Analysis; ras Proteins; Repressor Proteins; RNA Interference | 2010 |
Aberrantly silenced promoters retain a persistent memory of the silenced state after long-term reactivation.
Topics: Adenine Phosphoribosyltransferase; Animals; Azacitidine; Cell Line, Tumor; Chromatin Immunoprecipitation; CpG Islands; Decitabine; DNA Methylation; DNA Modification Methylases; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Histones; Hydroxamic Acids; Lysine; Methylation; Mice; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; Time Factors | 2011 |
Drosophila vigilin, DDP1, localises to the cytoplasm and associates to the rough endoplasmic reticulum.
Topics: Animals; Animals, Genetically Modified; Blotting, Western; Cells, Cultured; Cytoplasm; DNA-Binding Proteins; Drosophila melanogaster; Drosophila Proteins; Embryo, Nonmammalian; Endoplasmic Reticulum, Rough; Female; Green Fluorescent Proteins; Heterochromatin; Histones; Immunohistochemistry; Lysine; Male; Methylation; Microscopy, Immunoelectron; Mutation; Protein Binding; Ribosomal Proteins; RNA Interference; RNA-Binding Proteins; Schizosaccharomyces; Schizosaccharomyces pombe Proteins | 2011 |
Genetically directing ɛ-N, N-dimethyl-L-lysine in recombinant histones.
Topics: Chromobox Protein Homolog 5; Chromosomal Proteins, Non-Histone; Histones; Immunoprecipitation; Lysine; Methylation; Protein Processing, Post-Translational; Recombinant Proteins | 2010 |
Global epigenomic analysis of primary human pancreatic islets provides insights into type 2 diabetes susceptibility loci.
Topics: CCCTC-Binding Factor; Deoxyribonuclease I; Diabetes Mellitus, Type 2; Epigenomics; Genetic Loci; Genome-Wide Association Study; HeLa Cells; Histones; Humans; Islets of Langerhans; Lysine; Methylation; Promoter Regions, Genetic; Regulatory Sequences, Nucleic Acid; Repressor Proteins | 2010 |
Female-biased expression of long non-coding RNAs in domains that escape X-inactivation in mouse.
Topics: Animals; Brain; Female; Gene Expression Profiling; Gene Expression Regulation; Genes, X-Linked; Histones; Lysine; Male; Methylation; Mice; Multigene Family; Oligonucleotide Array Sequence Analysis; Open Reading Frames; Organ Specificity; Reproducibility of Results; Reverse Transcriptase Polymerase Chain Reaction; RNA, Untranslated; Sex Characteristics; X Chromosome; X Chromosome Inactivation | 2010 |
Dynamic changes in genome-wide histone H3 lysine 4 methylation patterns in response to dehydration stress in Arabidopsis thaliana.
Topics: Abscisic Acid; Arabidopsis; Chromatin Immunoprecipitation; Dehydration; Gene Expression Profiling; Genome, Plant; High-Throughput Nucleotide Sequencing; Histones; Lysine; Methylation; Plant Growth Regulators; Stress, Physiological | 2010 |
Altering a histone H3K4 methylation pathway in glomerular podocytes promotes a chronic disease phenotype.
Topics: Animals; Carrier Proteins; Chronic Disease; DNA-Binding Proteins; Female; Gene Expression Profiling; Histones; Kidney; Kidney Diseases; Kidney Glomerulus; Lysine; Male; Methylation; Mice; Mice, Knockout; Microscopy, Electron, Scanning; Microscopy, Electron, Transmission; Microscopy, Fluorescence; Mutation; Nuclear Proteins; Oligonucleotide Array Sequence Analysis; Podocytes; Receptor, trkC; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction | 2010 |
Continuous requirement for the Clr4 complex but not RNAi for centromeric heterochromatin assembly in fission yeast harboring a disrupted RITS complex.
Topics: Argonaute Proteins; Carrier Proteins; Cell Cycle Proteins; Centromere; Chromatin Immunoprecipitation; Chromosomal Proteins, Non-Histone; Cullin Proteins; Heterochromatin; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Methyltransferases; Mutation; RNA Interference; RNA-Binding Proteins; Schizosaccharomyces; Schizosaccharomyces pombe Proteins | 2010 |
DSIF and RNA polymerase II CTD phosphorylation coordinate the recruitment of Rpd3S to actively transcribed genes.
Topics: Chromatin Immunoprecipitation; Chromosomal Proteins, Non-Histone; Cyclin-Dependent Kinases; Gene Expression Profiling; Gene Expression Regulation, Fungal; Histone Deacetylases; Histones; Isoenzymes; Lysine; Methylation; Methyltransferases; Mutation; Nuclear Proteins; Oligonucleotide Array Sequence Analysis; Open Reading Frames; Phosphorylation; Protein Binding; Protein Kinases; RNA Polymerase II; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Transcription, Genetic; Transcriptional Elongation Factors | 2010 |
Stress-induced activation of heterochromatic transcription.
Topics: Arabidopsis; Cold Temperature; Gene Expression Profiling; Glucuronidase; Heterochromatin; Histones; Lysine; Methylation; Oligonucleotide Array Sequence Analysis; Plants, Genetically Modified; Reverse Transcriptase Polymerase Chain Reaction; Seedlings; Sodium Chloride; Stress, Physiological; Temperature; Time Factors; Transcription, Genetic; Transcriptional Activation | 2010 |
MiR-138 inhibits EZH2 methyltransferase expression and methylation of histone H3 at lysine 27, and affects thermotolerance acquisition.
Topics: Animals; Body Temperature Regulation; Chickens; Histone-Lysine N-Methyltransferase; Histones; Hot Temperature; Hypothalamus, Anterior; Lysine; Male; Methylation; MicroRNAs; Preoptic Area | 2011 |
Structural studies of the tandem Tudor domains of fragile X mental retardation related proteins FXR1 and FXR2.
Topics: Amino Acid Sequence; Binding Sites; Computer Simulation; Crystallography, X-Ray; Fragile X Mental Retardation Protein; Histones; Humans; Lysine; Magnetic Resonance Spectroscopy; Methylation; Models, Molecular; Molecular Sequence Data; Nuclear Localization Signals; Protein Binding; Protein Structure, Tertiary; RNA-Binding Proteins; Sequence Homology, Amino Acid; Tandem Repeat Sequences | 2010 |
RNA polymerase II binding patterns reveal genomic regions involved in microRNA gene regulation.
Topics: Algorithms; Cell Line, Tumor; Chromatin Immunoprecipitation; Computational Biology; CpG Islands; Gene Expression Regulation; Histones; Humans; Lysine; Methylation; MicroRNAs; Promoter Regions, Genetic; Protein Binding; Regulatory Sequences, Nucleic Acid; RNA Polymerase II; Transcription Initiation Site; Transcription, Genetic | 2010 |
Coordinated activities of wild-type plus mutant EZH2 drive tumor-associated hypertrimethylation of lysine 27 on histone H3 (H3K27) in human B-cell lymphomas.
Topics: Catalysis; DNA-Binding Proteins; Enhancer of Zeste Homolog 2 Protein; Histones; Humans; Kinetics; Lymphoma, B-Cell; Lysine; Methylation; Point Mutation; Polycomb Repressive Complex 2; Transcription Factors | 2010 |
Changes to euchromatin on LAT and ICP4 following reactivation are more prevalent in an efficiently reactivating strain of HSV-1.
Topics: Adrenergic Agonists; Animals; Chromatin Assembly and Disassembly; Cornea; Epinephrine; Euchromatin; Exons; Herpesvirus 1, Human; Histones; Humans; Immediate-Early Proteins; Lysine; Methylation; MicroRNAs; Promoter Regions, Genetic; Rabbits; Reverse Transcriptase Polymerase Chain Reaction; RNA, Viral; Time Factors; Trigeminal Ganglion; Virus Activation | 2010 |
Reversible methylation of promoter-bound STAT3 by histone-modifying enzymes.
Topics: Active Transport, Cell Nucleus; Cell Line; Histone Demethylases; Histone-Lysine N-Methyltransferase; Histones; Humans; Interleukin-6; Lysine; Methylation; Promoter Regions, Genetic; STAT3 Transcription Factor; Suppressor of Cytokine Signaling 3 Protein; Suppressor of Cytokine Signaling Proteins | 2010 |
Histone H3 trimethylation at lysine 9 marks the inactive metaphase X chromosome in the marsupial Monodelphis domestica.
Topics: Animals; Cell Line; Chromatin; Female; Histones; Lysine; Male; Metaphase; Methylation; Monodelphis; X Chromosome; X Chromosome Inactivation | 2011 |
Interplay between lysine methylation and Cdk phosphorylation in growth control by the retinoblastoma protein.
Topics: Cell Cycle; Cell Line, Tumor; Chromatin Immunoprecipitation; Cyclin-Dependent Kinases; Flow Cytometry; Humans; Immunoblotting; Immunoprecipitation; Luciferases; Lysine; Mass Spectrometry; Methylation; Models, Molecular; Phosphorylation; Protein Binding; Retinoblastoma Protein | 2011 |
Essential functions of the histone demethylase lid.
Topics: Animals; DNA-Binding Proteins; Drosophila melanogaster; Drosophila Proteins; Enzyme Activation; Eye; Genome; Histone Demethylases; Histone-Lysine N-Methyltransferase; Histones; Lysine; Male; Methylation; Mutation; Paraquat; Protein Binding; Protein Structure, Tertiary; Sequence Deletion; Time Factors; Transcription Factors; Transgenes; Zinc Fingers | 2010 |
CTCF-dependent chromatin bias constitutes transient epigenetic memory of the mother at the H19-Igf2 imprinting control region in prospermatogonia.
Topics: Alleles; Animals; CCCTC-Binding Factor; Chromatin; DNA Methylation; Female; Fetus; Genomic Imprinting; Histones; Insulin-Like Growth Factor II; Lysine; Male; Methylation; Mice; Models, Biological; Mutation; Protein Binding; Repressor Proteins; Reproducibility of Results; RNA, Long Noncoding; RNA, Untranslated; Sequence Analysis, DNA; Spermatogonia; Sulfites | 2010 |
Quantitative high-throughput screening identifies 8-hydroxyquinolines as cell-active histone demethylase inhibitors.
Topics: Biocatalysis; Dose-Response Relationship, Drug; Drug Evaluation, Preclinical; Enzyme Inhibitors; HeLa Cells; Histones; Humans; Hydroxyquinolines; Jumonji Domain-Containing Histone Demethylases; Lysine; Mass Spectrometry; Methylation; Molecular Structure | 2010 |
An Ash2L/RbBP5 heterodimer stimulates the MLL1 methyltransferase activity through coordinated substrate interactions with the MLL1 SET domain.
Topics: Binding Sites; DNA-Binding Proteins; HeLa Cells; Histone-Lysine N-Methyltransferase; Histones; Humans; Immunoprecipitation; Lysine; Methylation; Methyltransferases; Models, Biological; Mutation; Myeloid-Lymphoid Leukemia Protein; Nuclear Proteins; Protein Binding; Protein Multimerization; RNA Interference; S-Adenosylmethionine; Substrate Specificity; Transcription Factors | 2010 |
Ectopic T cell receptor-α locus control region activity in B cells is suppressed by direct linkage to two flanking genes at once.
Topics: Animals; Apoptosis Regulatory Proteins; B-Lymphocytes; CD2 Antigens; Flow Cytometry; Gene Expression Regulation; Histones; HLA-B7 Antigen; Humans; Locus Control Region; Lymphoid Tissue; Lysine; Membrane Proteins; Methylation; Mice; Mice, Transgenic; Promoter Regions, Genetic; Receptors, Antigen, T-Cell, alpha-beta; Reverse Transcriptase Polymerase Chain Reaction; Spleen; Thymus Gland | 2010 |
Identification of trimethylation at C-terminal lysine of pilin in the cyanobacterium Synechocystis PCC 6803.
Topics: Amino Acid Sequence; Amino Acid Substitution; Fimbriae Proteins; Lysine; Methylation; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein Processing, Post-Translational; Synechocystis | 2011 |
CDK1-dependent phosphorylation of EZH2 suppresses methylation of H3K27 and promotes osteogenic differentiation of human mesenchymal stem cells.
Topics: 2-Aminopurine; Carrier Proteins; CDC2 Protein Kinase; Cell Differentiation; Cell Line; Cell Line, Tumor; Cell Movement; DNA-Binding Proteins; Enhancer of Zeste Homolog 2 Protein; HEK293 Cells; HeLa Cells; Histone-Lysine N-Methyltransferase; Histones; Humans; Immunoblotting; Lysine; Mesenchymal Stem Cells; Methylation; Neoplasm Proteins; Nuclear Proteins; Osteoblasts; Phosphorylation; Polycomb Repressive Complex 2; Protein Binding; Repressor Proteins; RNA Interference; Threonine; Transcription Factors | 2011 |
Proteomic characterization of archaeal ribosomes reveals the presence of novel archaeal-specific ribosomal proteins.
Topics: Archaeal Proteins; Binding Sites; Lysine; Methylation; Nucleoside-Triphosphatase; Phylogeny; Proteomics; Pyrobaculum; Ribosomal Proteins; Ribosomes; Sulfolobus acidocaldarius | 2011 |
Histone3 lysine4 trimethylation regulated by the facilitates chromatin transcription complex is critical for DNA cleavage in class switch recombination.
Topics: Animals; B-Lymphocytes; Cell Line; Chromatin; Cytidine Deaminase; DNA; DNA-Binding Proteins; Evolution, Molecular; High Mobility Group Proteins; Histones; Immunoglobulin Class Switching; Lysine; Meiosis; Methylation; Mice; Transcription, Genetic; VDJ Recombinases | 2010 |
Autoinhibition of DNA cleavage mediated by RAG1 and RAG2 is overcome by an epigenetic signal in V(D)J recombination.
Topics: Animals; Binding Sites; DNA Cleavage; DNA-Binding Proteins; Electrophoresis, Polyacrylamide Gel; Electrophoretic Mobility Shift Assay; Epigenomics; HEK293 Cells; Histones; Homeodomain Proteins; Humans; Lysine; Methylation; Mice; Mutation; Protein Binding; Protein Multimerization; Recombination, Genetic; Signal Transduction; VDJ Exons | 2010 |
L3MBTL1 polycomb protein, a candidate tumor suppressor in del(20q12) myeloid disorders, is essential for genome stability.
Topics: Blotting, Western; Cell Cycle; Cell Line; Cell Line, Tumor; Cell Proliferation; Chromosomal Proteins, Non-Histone; Chromosome Deletion; Chromosomes, Human, Pair 20; DNA Damage; DNA Replication; Genomic Instability; HEK293 Cells; Histones; Humans; Immunoprecipitation; K562 Cells; Lysine; Methylation; Myeloproliferative Disorders; Neoplasm Proteins; Protein Binding; Repressor Proteins; Retinoblastoma Protein; RNA Interference; Tumor Suppressor Proteins | 2010 |
A methylation and phosphorylation switch between an adjacent lysine and serine determines human DNMT1 stability.
Topics: Crystallography, X-Ray; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Genome, Human; Histone-Lysine N-Methyltransferase; Humans; Lysine; Methylation; Models, Molecular; Phosphorylation; Protein Stability; Protein Structure, Tertiary; Proto-Oncogene Proteins c-akt; Serine | 2011 |
Lysine methylation of promoter-bound transcription factors and relevance to cancer.
Topics: DNA; Histone-Lysine N-Methyltransferase; Humans; Lysine; Methylation; Neoplasms; NF-kappa B; Promoter Regions, Genetic; STAT3 Transcription Factor | 2011 |
CpG array analysis of histone H3 lysine 4 trimethylation in peripheral blood mononuclear cells of uremia patients.
Topics: Adult; Basic Helix-Loop-Helix Transcription Factors; CpG Islands; DNA Methylation; Female; Histones; Humans; Leukocytes, Mononuclear; Lysine; Male; Methylation; Microarray Analysis; Middle Aged; Phospholipid Transfer Proteins; Receptors, KIR3DL2; Receptors, Lysosphingolipid; Sphingosine-1-Phosphate Receptors; Transcription Factors; Uremia | 2011 |
Histone H3 lysine 79 methyltransferase Dot1 is required for immortalization by MLL oncogenes.
Topics: Animals; Apoptosis; Cell Transformation, Neoplastic; Hematopoietic Stem Cells; Histone-Lysine N-Methyltransferase; Histones; Leukemia, Experimental; Lysine; Methylation; Methyltransferases; Mice; Myeloid-Lymphoid Leukemia Protein | 2010 |
A unique chromatin signature uncovers early developmental enhancers in humans.
Topics: Acetylation; Animals; Cell Differentiation; Cell Line; Chromatin; Chromatin Immunoprecipitation; DNA Helicases; Embryonic Development; Embryonic Stem Cells; Enhancer Elements, Genetic; Epigenesis, Genetic; Gastrulation; Gene Expression Regulation, Developmental; Germ Layers; Histones; Humans; Lysine; Mesoderm; Methylation; Neural Plate; Neurulation; Nuclear Proteins; p300-CBP Transcription Factors; RNA; Transcription Factors; Zebrafish | 2011 |
Tiling histone H3 lysine 4 and 27 methylation in zebrafish using high-density microarrays.
Topics: Animals; Chromatin; DNA Methylation; Epigenesis, Genetic; Fibroblasts; Gene Expression Regulation; Histones; Humans; Immunoprecipitation; Lysine; Methylation; Mice; Oligonucleotide Array Sequence Analysis; Promoter Regions, Genetic; Zebrafish | 2010 |
Role for cohesin in the formation of a heterochromatic domain at fission yeast subtelomeres.
Topics: Cell Cycle Proteins; Centromere; Chromosomal Proteins, Non-Histone; Cohesins; Down-Regulation; Euchromatin; Gene Expression Profiling; Gene Expression Regulation, Fungal; Gene Silencing; Heterochromatin; Lysine; Methylation; Mutation; Nuclear Proteins; Phosphoproteins; Schizosaccharomyces; Schizosaccharomyces pombe Proteins; Telomere; Up-Regulation | 2011 |
Exploring the use of dimethylsulfate for in vivo proteome footprinting.
Topics: Amino Acid Sequence; Animals; Chromatin; Glutamic Acid; HeLa Cells; Histidine; Histones; Humans; Lysine; Methylation; Molecular Sequence Data; Protein Folding; Protein Multimerization; Proteome; Proteomics; Sulfuric Acid Esters; Xenopus | 2011 |
Overexpression of Enhancer of zeste homolog 2 with trimethylation of lysine 27 on histone H3 in adult T-cell leukemia/lymphoma as a target for epigenetic therapy.
Topics: Adenosine; Base Sequence; Blotting, Western; CD4-Positive T-Lymphocytes; Cell Line, Tumor; Cell Proliferation; DNA-Binding Proteins; Enhancer of Zeste Homolog 2 Protein; Epigenomics; Gene Expression Profiling; Gene Expression Regulation, Leukemic; Histones; Humans; Hydroxamic Acids; Indoles; Intracellular Signaling Peptides and Proteins; Leukemia-Lymphoma, Adult T-Cell; Lysine; Methylation; MicroRNAs; Oligonucleotide Array Sequence Analysis; Panobinostat; Polycomb Repressive Complex 1; Polycomb Repressive Complex 2; Repressor Proteins; Reverse Transcriptase Polymerase Chain Reaction; Transcription Factors | 2011 |
Identification of lysine 37 of histone H2B as a novel site of methylation.
Topics: Histone Code; Histones; Lysine; Mass Spectrometry; Methylation; Protein Processing, Post-Translational; Saccharomyces cerevisiae | 2011 |
Dynamic BRG1 recruitment during T helper differentiation and activation reveals distal regulatory elements.
Topics: Animals; Binding Sites; Cell Differentiation; Cell Lineage; Chromatin; CpG Islands; DNA Helicases; Enhancer Elements, Genetic; GATA3 Transcription Factor; Histones; Lymphocyte Activation; Lymphocyte Subsets; Lysine; Methylation; Mice; Mice, Inbred BALB C; MicroRNAs; Nuclear Proteins; Organ Specificity; Promoter Regions, Genetic; Protein Binding; STAT Transcription Factors; T-Lymphocytes, Helper-Inducer; Transcription Factors; Transcription Initiation Site | 2011 |
Symmetry, asymmetry, and kinetics of silencing establishment in Saccharomyces cerevisiae revealed by single-cell optical assays.
Topics: Biocatalysis; Cell Cycle; Chromatin; Gene Expression Regulation, Fungal; Gene Silencing; Green Fluorescent Proteins; Histone-Lysine N-Methyltransferase; Histones; Kinetics; Lysine; Methylation; Microscopy, Fluorescence; Mutation; Nuclear Proteins; Reverse Transcriptase Polymerase Chain Reaction; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Silent Information Regulator Proteins, Saccharomyces cerevisiae | 2011 |
Selective targeting of histone methylation.
Topics: Animals; Binding Sites; Cell Line; Chromosomal Proteins, Non-Histone; Drosophila melanogaster; Drosophila Proteins; Enhancer of Zeste Homolog 2 Protein; Epigenesis, Genetic; Gene Expression Regulation; Histone Demethylases; Histone-Lysine N-Methyltransferase; Histones; Humans; Jumonji Domain-Containing Histone Demethylases; Lysine; Methylation; Mice; Models, Genetic; Nerve Tissue Proteins; Nuclear Proteins; Polycomb Repressive Complex 2; Polycomb-Group Proteins; Protein Processing, Post-Translational; Repressor Proteins; Retinoblastoma-Binding Protein 2; Transcription, Genetic | 2011 |
Lysine methylation and functional modulation of androgen receptor by Set9 methyltransferase.
Topics: Blotting, Western; Cell Line, Tumor; Histone-Lysine N-Methyltransferase; Humans; Immunoprecipitation; Lysine; Methylation; Mutation; Receptors, Androgen | 2011 |
Transcription-dependence of histone H3 lysine 27 trimethylation at the Arabidopsis polycomb target gene FLC.
Topics: Arabidopsis; Arabidopsis Proteins; Flowers; Gene Expression Regulation, Plant; Genes, Plant; Histones; Lysine; MADS Domain Proteins; Methylation; Mutation; Phenotype; Plants, Genetically Modified; Polycomb-Group Proteins; Promoter Regions, Genetic; Repressor Proteins; RNA, Messenger; RNA, Plant; Transcription, Genetic | 2011 |
Role of PTIP in class switch recombination and long-range chromatin interactions at the immunoglobulin heavy chain locus.
Topics: Animals; B-Lymphocytes; Carrier Proteins; Chromatin; DNA-Binding Proteins; Gene Deletion; Gene Expression Regulation; Genes, Immunoglobulin Heavy Chain; Genetic Loci; HEK293 Cells; Histones; Humans; Immunoglobulin Class Switching; Lymphocyte Activation; Lysine; Methylation; Methyltransferases; Mice; Models, Genetic; Mutation; Nuclear Proteins; Nucleic Acid Conformation; PAX5 Transcription Factor; Protein Binding; Protein Transport; Recombination, Genetic | 2011 |
Histone H4 Lys 20 monomethylation by histone methylase SET8 mediates Wnt target gene activation.
Topics: Animals; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Biomarkers; Histone-Lysine N-Methyltransferase; Histones; Lymphoid Enhancer-Binding Factor 1; Lysine; Mammals; Methylation; Signal Transduction; Transcription Factor 4; Transcription Factors; Transcriptional Activation; Wnt Proteins; Wnt3 Protein; Wnt3A Protein; Zebrafish; Zebrafish Proteins | 2011 |
The antioxidant protein peroxiredoxin 4 is epigenetically down regulated in acute promyelocytic leukemia.
Topics: Antioxidants; Down-Regulation; Epigenesis, Genetic; Granulocyte Colony-Stimulating Factor; Histones; Humans; Leukemia, Promyelocytic, Acute; Lysine; Methylation; Peroxiredoxins; Transcription Initiation Site | 2011 |
MMSET regulates histone H4K20 methylation and 53BP1 accumulation at DNA damage sites.
Topics: Adaptor Proteins, Signal Transducing; Ataxia Telangiectasia Mutated Proteins; Cell Cycle Proteins; Chromatin Immunoprecipitation; DNA Breaks, Double-Stranded; DNA-Binding Proteins; HEK293 Cells; HeLa Cells; Histone-Lysine N-Methyltransferase; Histones; Humans; Intracellular Signaling Peptides and Proteins; Lysine; Methylation; Nuclear Proteins; Phosphorylation; Phosphoserine; Protein Serine-Threonine Kinases; Protein Transport; Repressor Proteins; Trans-Activators; Tumor Suppressor p53-Binding Protein 1; Tumor Suppressor Proteins | 2011 |
Cocaine dynamically regulates heterochromatin and repetitive element unsilencing in nucleus accumbens.
Topics: Analysis of Variance; Animals; Base Sequence; Blotting, Western; Chromatin Immunoprecipitation; Cocaine; Cocaine-Related Disorders; DNA Primers; Gene Regulatory Networks; Genomic Instability; Heterochromatin; Histones; Immunohistochemistry; Long Interspersed Nucleotide Elements; Lysine; Methylation; Mice; Models, Statistical; Molecular Sequence Data; Nucleus Accumbens; Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; Reward; Sequence Analysis, DNA | 2011 |
Structure of the putative dihydroorotate dehydrogenase from Streptococcus mutans.
Topics: Amino Acid Sequence; Binding Sites; Catalysis; Conserved Sequence; Crystallography, X-Ray; Dental Caries; Dihydroorotate Dehydrogenase; Dimerization; Escherichia coli; Flavin Mononucleotide; Histidine; Humans; Hydrophobic and Hydrophilic Interactions; Lysine; Methylation; Models, Molecular; Molecular Sequence Data; Orotic Acid; Oxidation-Reduction; Oxidoreductases Acting on CH-CH Group Donors; Protein Conformation; Protein Folding; Protein Structure, Quaternary; Protein Structure, Secondary; Protein Subunits; Pyrimidines; Recombinant Proteins; Sequence Homology, Amino Acid; Streptococcus mutans; Substrate Specificity; X-Ray Diffraction | 2011 |
Genome-wide chromatin occupancy analysis reveals a role for ASH2 in transcriptional pausing.
Topics: Animals; Chromatin; Drosophila; Drosophila Proteins; Genome, Insect; Histones; Lysine; Methylation; Mutation; Nuclear Proteins; Phosphorylation; Promoter Regions, Genetic; RNA Polymerase II; Transcription Factors; Transcriptional Activation | 2011 |
Methylation-mediated regulation of E2F1 in DNA damage-induced cell death.
Topics: Amino Acid Sequence; Cell Death; Cell Line; DNA Damage; E2F1 Transcription Factor; Gene Knockdown Techniques; Histone Demethylases; Histone-Lysine N-Methyltransferase; Humans; Lysine; Methylation; Molecular Sequence Data; Protein Stability; Transcription, Genetic; Tumor Suppressor Protein p53 | 2011 |
Toxoplasma gondii sequesters centromeres to a specific nuclear region throughout the cell cycle.
Topics: Cell Cycle; Centromere; Chromatin Immunoprecipitation; Chromosome Breakage; Etoposide; Fluorescent Antibody Technique; Histones; Humans; Lysine; Methylation; Mitosis; Oligonucleotide Array Sequence Analysis; Reproducibility of Results; Toxoplasma | 2011 |
Symmetrical modification within a nucleosome is not required globally for histone lysine methylation.
Topics: Cell Line; HeLa Cells; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Mass Spectrometry; Methylation; Nucleosomes; Protein Processing, Post-Translational | 2011 |
Association between mitochondrial DNA haplotype compatibility and increased efficiency of bovine intersubspecies cloning.
Topics: Adenosine Triphosphate; Animals; Blastocyst; Cattle; Cloning, Organism; Dairying; DNA, Mitochondrial; Embryo Implantation; Female; Haplotypes; Histones; Lysine; Methylation; Nuclear Transfer Techniques; Promoter Regions, Genetic | 2011 |
Characterization of the contradictory chromatin signatures at the 3' exons of zinc finger genes.
Topics: Chromatin; Exons; HEK293 Cells; Histones; Humans; Lysine; Methylation; Zinc Fingers | 2011 |
Histone H3 lysine 9 trimethylation and HP1γ favor inclusion of alternative exons.
Topics: Alternative Splicing; Cell Line; Chromosomal Proteins, Non-Histone; Exons; HeLa Cells; Histones; Humans; Hyaluronan Receptors; Lysine; Methylation; RNA Polymerase II; RNA Precursors | 2011 |
Deacetylation and methylation at histone H3 lysine 9 (H3K9) coordinate chromosome condensation during cell cycle progression.
Topics: Acetylation; Cell Cycle; Cell Line, Tumor; Chromatin; Chromosomes, Human; Histones; Humans; Hydroxymethyl and Formyl Transferases; Lysine; Methylation; Nocodazole; Nucleic Acid Conformation; Protein Processing, Post-Translational | 2011 |
Controlling transcriptional programs for cellular adaptation by chromatin regulation.
Topics: Acetylation; Adaptation, Physiological; Chromatin; Fungal Proteins; Gene Expression Profiling; Gene Expression Regulation, Developmental; Gene Expression Regulation, Fungal; Histones; Lysine; Methylation; Models, Genetic; Nucleosomes; Promoter Regions, Genetic; Protein Processing, Post-Translational; Stress, Physiological; Transcription, Genetic; Yeasts | 2011 |
Small-molecule ligands of methyl-lysine binding proteins.
Topics: Binding Sites; Calorimetry; Drug Discovery; High-Throughput Screening Assays; Humans; Ligands; Luminescent Measurements; Lysine; Methylation; Models, Molecular; Nuclear Proteins; Peptidomimetics; Protein Structure, Tertiary; Small Molecule Libraries | 2011 |
The ATRX-ADD domain binds to H3 tail peptides and reads the combined methylation state of K4 and K9.
Topics: 3T3 Cells; alpha-Thalassemia; Amino Acid Sequence; Animals; Chromatin; Cloning, Molecular; DNA Helicases; Gene Expression; HEK293 Cells; Histones; Humans; Lysine; Mental Retardation, X-Linked; Methylation; Mice; Molecular Sequence Data; Mutagenesis, Site-Directed; Mutation; Nuclear Proteins; Peptides; Protein Binding; Protein Interaction Domains and Motifs; Protein Structure, Quaternary; X-linked Nuclear Protein | 2011 |
A long noncoding RNA maintains active chromatin to coordinate homeotic gene expression.
Topics: Animals; Cell Line; Cells, Cultured; Chromatin; DNA, Intergenic; Embryo, Mammalian; Fibroblasts; Gene Expression Regulation, Developmental; Gene Knockdown Techniques; Genes, Homeobox; Histone-Lysine N-Methyltransferase; Histones; Humans; Intracellular Signaling Peptides and Proteins; Lysine; Methylation; Mice; Molecular Sequence Data; Multigene Family; Organ Specificity; RNA, Untranslated; Transcription, Genetic | 2011 |
Biophysical probes reveal a "compromise" nature of the methyl-lysine binding pocket in L3MBTL1.
Topics: Binding Sites; Biomimetic Materials; Histones; Lysine; Methylation; Molecular Dynamics Simulation; Molecular Probes; Nuclear Proteins; Protein Conformation; Protein Structure, Tertiary; Thermodynamics | 2011 |
Identification of cis regulatory features in the embryonic zebrafish genome through large-scale profiling of H3K4me1 and H3K4me3 binding sites.
Topics: Animals; Binding Sites; Conserved Sequence; DNA, Intergenic; Embryo, Nonmammalian; Enhancer Elements, Genetic; Gene Expression Profiling; Gene Expression Regulation, Developmental; Genome; Histones; Lysine; Methylation; Protein Binding; Regulatory Sequences, Nucleic Acid; Transcription Initiation Site; Zebrafish; Zebrafish Proteins | 2011 |
Identification of a role for histone H2B ubiquitylation in noncoding RNA 3'-end formation through mutational analysis of Rtf1 in Saccharomyces cerevisiae.
Topics: Amino Acid Sequence; Blotting, Northern; Blotting, Western; Gene Expression Regulation, Fungal; Histones; Humans; Lysine; Methylation; Molecular Sequence Data; Mutation; RNA, Small Nucleolar; RNA, Untranslated; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sequence Homology, Amino Acid; TATA-Box Binding Protein; Ubiquitination | 2011 |
Differential contributions of histone H3 and H4 residues to heterochromatin structure.
Topics: Acetylation; Amino Acid Sequence; Amino Acids; Arginine; Chromatin; DNA, Fungal; Gene Expression Regulation, Fungal; Heterochromatin; Histones; Lysine; Methylation; Molecular Sequence Data; Mutation; Nucleosomes; Phosphorylation; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Serine; Transcription, Genetic | 2011 |
The role of cotranscriptional histone methylations.
Topics: Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Models, Biological; Promoter Regions, Genetic; Saccharomyces cerevisiae; Signal Transduction; Transcription, Genetic | 2010 |
Nfat1 regulates adult articular chondrocyte function through its age-dependent expression mediated by epigenetic histone methylation.
Topics: Aging; Animals; Base Sequence; Cartilage, Articular; Chondrocytes; Chromatin Immunoprecipitation; Epigenesis, Genetic; Gene Knockdown Techniques; Histone Demethylases; Histones; Jumonji Domain-Containing Histone Demethylases; Lysine; Methylation; Mice; Molecular Sequence Data; NFATC Transcription Factors; Osteoarthritis; Oxidoreductases, N-Demethylating; Promoter Regions, Genetic; RNA Interference; RNA, Small Interfering; Up-Regulation | 2011 |
Genome-wide analysis reveals novel molecular features of mouse recombination hotspots.
Topics: Animals; Chromosome Mapping; Chromosome Segregation; Chromosomes, Mammalian; Consensus Sequence; Crossing Over, Genetic; DNA Breaks, Double-Stranded; Genetic Markers; Genome; Genomics; Histones; Lysine; Male; Meiosis; Methylation; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Nucleosomes; Organ Specificity; Recombination, Genetic; Sister Chromatid Exchange; Testis; Transcription, Genetic | 2011 |
Functional nuclear organization of transcription and DNA replication: a topographical marriage between chromatin domains and the interchromatin compartment.
Topics: Animals; Cell Compartmentation; Chromatin; DNA; DNA Replication; Fibroblasts; HeLa Cells; Histones; Humans; Lysine; Methylation; Microscopy; Nuclear Matrix; Protein Processing, Post-Translational; RNA; RNA Polymerase II; RNA Splicing; Transcription, Genetic | 2010 |
H3 lysine 4 is acetylated at active gene promoters and is regulated by H3 lysine 4 methylation.
Topics: Acetylation; Euchromatin; Gene Expression Regulation, Enzymologic; Gene Regulatory Networks; Heterochromatin; Histone Acetyltransferases; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Promoter Regions, Genetic; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Silent Information Regulator Proteins, Saccharomyces cerevisiae; Sirtuin 2 | 2011 |
Structural basis of SETD6-mediated regulation of the NF-kB network via methyl-lysine signaling.
Topics: Amino Acid Sequence; Ankyrin Repeat; Cell Line; Gene Expression Regulation; Histone-Lysine N-Methyltransferase; Humans; Lysine; Methylation; Models, Molecular; Molecular Sequence Data; NF-kappa B; Protein Methyltransferases; Signal Transduction; Structural Homology, Protein; Transcription Factor RelA | 2011 |
Caenorhabditis elegans chromatin-associated proteins SET-2 and ASH-2 are differentially required for histone H3 Lys 4 methylation in embryos and adult germ cells.
Topics: Animals; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Embryo, Nonmammalian; Germ Cells; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Nuclear Proteins; Saccharomyces cerevisiae Proteins | 2011 |
Evolution from XIST-independent to XIST-controlled X-chromosome inactivation: epigenetic modifications in distantly related mammals.
Topics: Animals; Epigenesis, Genetic; Evolution, Molecular; Female; Fluorescent Antibody Technique; Heterochromatin; Histones; Humans; Lysine; Male; Mammals; Marsupialia; Methylation; Mice; Models, Genetic; Phylogeny; RNA, Long Noncoding; RNA, Untranslated; Transcription, Genetic; X Chromosome; X Chromosome Inactivation | 2011 |
Prediction and analysis of protein methylarginine and methyllysine based on Multisequence features.
Topics: Arginine; Lysine; Methylation; Models, Biological | 2011 |
Inhibition of histone lysine methylation enhances cancer-testis antigen expression in lung cancer cells: implications for adoptive immunotherapy of cancer.
Topics: Antigens, Neoplasm; Cell Line, Tumor; Chromatin; DNA Methylation; Enzyme Inhibitors; Gene Expression Profiling; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; Immunotherapy, Adoptive; Lung Neoplasms; Lysine; Melanoma-Specific Antigens; Membrane Proteins; Methylation; Neoplasm Proteins | 2011 |
Histone methylation by PRC2 is inhibited by active chromatin marks.
Topics: Amino Acid Sequence; Animals; Blotting, Western; Cell Line; Chromatin; Crystallography, X-Ray; Drosophila; Drosophila Proteins; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Mice; Models, Molecular; Molecular Sequence Data; Mutation; Polycomb Repressive Complex 2; Polycomb-Group Proteins; Protein Binding; Protein Structure, Tertiary; Repressor Proteins; Retinoblastoma-Binding Protein 4; Transcription, Genetic | 2011 |
Genome-wide remodeling of the epigenetic landscape during myogenic differentiation.
Topics: Animals; Cell Differentiation; Chromatin; Embryonic Stem Cells; Epigenesis, Genetic; Genome-Wide Association Study; Histones; Humans; Lysine; Methylation; Mice; Muscle Development; Muscles; Phenotype; Polycomb-Group Proteins; Repressor Proteins; Transcription, Genetic | 2011 |
A modulated empirical Bayes model for identifying topological and temporal estrogen receptor α regulatory networks in breast cancer.
Topics: Bayes Theorem; Breast Neoplasms; Cell Line, Tumor; Drug Resistance, Neoplasm; Epigenesis, Genetic; Estrogen Receptor alpha; Gene Regulatory Networks; Genomics; Histones; Humans; Lysine; Methylation; Models, Genetic; Reproducibility of Results; RNA Polymerase II; Tamoxifen; Time Factors | 2011 |
Tracking epigenetic histone modifications in single cells using Fab-based live endogenous modification labeling.
Topics: Acetylation; Animals; Antibodies, Monoclonal; Blastocyst; Cells, Cultured; Chromosomes, Human, X; Epigenesis, Genetic; Female; Fluorescence Recovery After Photobleaching; Fluorescent Dyes; Histone Deacetylase Inhibitors; Histones; Humans; Hydroxamic Acids; Immunoglobulin Fab Fragments; Lysine; Male; Methylation; Mice; Microscopy, Confocal; Protein Processing, Post-Translational; Single-Cell Analysis | 2011 |
Differentiation-independent fluctuation of pluripotency-related transcription factors and other epigenetic markers in embryonic stem cell colonies.
Topics: Animals; Blotting, Western; Cell Differentiation; Cell Nucleus; Cells, Cultured; Embryonic Stem Cells; Epigenesis, Genetic; Fluorescence Recovery After Photobleaching; G2 Phase; Green Fluorescent Proteins; Histones; Homeodomain Proteins; Ki-67 Antigen; Lysine; Methylation; Mice; Microscopy, Confocal; Nanog Homeobox Protein; Octamer Transcription Factor-3; Pluripotent Stem Cells; Proto-Oncogene Proteins c-myc; Stem Cell Niche | 2012 |
Modeling a new water channel that allows SET9 to dimethylate p53.
Topics: Catalysis; Crystallography, X-Ray; Histone-Lysine N-Methyltransferase; Humans; Lysine; Methylation; Models, Molecular; Molecular Dynamics Simulation; Protein Binding; Protein Conformation; S-Adenosylhomocysteine; S-Adenosylmethionine; Substrate Specificity; Tumor Suppressor Protein p53; Water | 2011 |
Investigating the cationic side chains of the antimicrobial peptide tritrpticin: hydrogen bonding properties govern its membrane-disruptive activities.
Topics: Anti-Bacterial Agents; Antimicrobial Cationic Peptides; Arginine; Bacillus subtilis; Cations; Erythrocytes; Escherichia coli; Guanidine; Hemolysis; Humans; Hydrogen Bonding; Lysine; Membranes; Methylation; Oligopeptides; Peptides; Spectrometry, Fluorescence; Staphylococcus aureus | 2011 |
Loss of H3K4 methylation destabilizes gene expression patterns and physiological functions in adult murine cardiomyocytes.
Topics: Animals; Calcium; Carrier Proteins; DNA-Binding Proteins; Epigenesis, Genetic; Gene Expression; Histones; Humans; Kv Channel-Interacting Proteins; Lysine; Methylation; Mice; Mice, Knockout; Myocytes, Cardiac; Nuclear Proteins; Ventricular Premature Complexes | 2011 |
ChIP-seq analysis reveals distinct H3K27me3 profiles that correlate with transcriptional activity.
Topics: Animals; Cells, Cultured; Chromatin Immunoprecipitation; Cluster Analysis; Histones; Lysine; Methylation; Mice; Mice, Inbred C57BL; Promoter Regions, Genetic; Sequence Analysis, DNA; Transcription Initiation Site; Transcription, Genetic | 2011 |
The requirement for pre-TCR during thymic differentiation enforces a developmental pause that is essential for V-DJβ rearrangement.
Topics: Animals; B7-2 Antigen; CD28 Antigens; Cell Differentiation; DNA-Binding Proteins; Gene Expression Regulation; Gene Rearrangement, alpha-Chain T-Cell Antigen Receptor; Gene Rearrangement, beta-Chain T-Cell Antigen Receptor; Histones; Lysine; Membrane Glycoproteins; Methylation; Mice; Mice, Transgenic; Receptors, Antigen, T-Cell, alpha-beta; T-Lymphocytes; Thymus Gland; Transcription, Genetic | 2011 |
The RNA helicase Rm62 cooperates with SU(VAR)3-9 to re-silence active transcription in Drosophila melanogaster.
Topics: Animals; Drosophila melanogaster; Histones; HSP70 Heat-Shock Proteins; Lysine; Methylation; Methyltransferases; Protein Binding; RNA Helicases; RNA Interference; Transcription, Genetic | 2011 |
Histone H2B ubiquitylation and H3 lysine 4 methylation prevent ectopic silencing of euchromatic loci important for the cellular response to heat.
Topics: Cell Wall; Euchromatin; Gene Expression Regulation, Fungal; Gene Silencing; Genetic Loci; Genome, Fungal; Heterochromatin; Histones; Hot Temperature; Lysine; Methylation; Plasmids; Protein Processing, Post-Translational; RNA, Messenger; Saccharomyces cerevisiae; Sequence Analysis, DNA; Silent Information Regulator Proteins, Saccharomyces cerevisiae; Site-Specific DNA-Methyltransferase (Adenine-Specific); Transcription, Genetic; Transfection; Ubiquitination | 2011 |
Role of yeast JmjC-domain containing histone demethylases in actively transcribed regions.
Topics: Chromatin Immunoprecipitation; Gene Expression Regulation, Fungal; Histone Demethylases; Histones; Jumonji Domain-Containing Histone Demethylases; Lysine; Methylation; Repressor Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Transcription, Genetic | 2011 |
Drosophila Set1 is the major histone H3 lysine 4 trimethyltransferase with role in transcription.
Topics: Animals; Blotting, Western; Chromatin Assembly and Disassembly; Chromatin Immunoprecipitation; Drosophila melanogaster; Drosophila Proteins; Gene Expression Regulation; Heat-Shock Proteins; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Immunoprecipitation; Lysine; Methylation; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; RNA Polymerase II; RNA, Messenger; Transcription, Genetic | 2011 |
H3K4 trimethylation by Set1 promotes efficient termination by the Nrd1-Nab3-Sen1 pathway.
Topics: Acetylation; Blotting, Northern; Chromatin Immunoprecipitation; DNA Helicases; Histone Deacetylases; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Mutation; Nuclear Proteins; Plasmids; Protein Binding; Reverse Transcriptase Polymerase Chain Reaction; RNA Helicases; RNA Polymerase II; RNA-Binding Proteins; RNA, Small Nucleolar; Saccharomyces cerevisiae Proteins; Signal Transduction; Transcription, Genetic | 2011 |
Structural and histone binding ability characterizations of human PWWP domains.
Topics: Amino Acid Sequence; Crystallography, X-Ray; Histones; Humans; Lysine; Magnetic Resonance Spectroscopy; Methylation; Models, Molecular; Molecular Sequence Data; Mutation; Peptides; Protein Binding; Protein Structure, Tertiary; Proteins; Sequence Alignment; Structural Homology, Protein; Titrimetry | 2011 |
Coordination of DNA replication and histone modification by the Rik1-Dos2 complex.
Topics: Cdc20 Proteins; Cell Cycle; Cell Cycle Proteins; Chromosomal Proteins, Non-Histone; Chromosomes, Fungal; DNA Replication; Epigenesis, Genetic; Gene Expression Regulation, Fungal; Gene Silencing; Heterochromatin; Histones; Lysine; Methylation; Multiprotein Complexes; RNA Interference; RNA Polymerase II; RNA, Small Interfering; Schizosaccharomyces; Schizosaccharomyces pombe Proteins; Transcription Factors; Transcription, Genetic | 2011 |
The von Hippel-Lindau tumor suppressor protein regulates gene expression and tumor growth through histone demethylase JARID1C.
Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Blotting, Western; Carcinoma, Renal Cell; Cell Line, Tumor; Cell Proliferation; Collagen Type VI; Gene Expression Regulation, Neoplastic; HEK293 Cells; Histone Demethylases; Histones; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Insulin-Like Growth Factor Binding Protein 3; Kidney Neoplasms; Lysine; Methylation; Mice; Mice, Nude; Mutation; Oxidoreductases, N-Demethylating; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Transplantation, Heterologous; Tumor Burden; Von Hippel-Lindau Tumor Suppressor Protein | 2012 |
H3K27me3 protein is a promising predictive biomarker of patients' survival and chemoradioresistance in human nasopharyngeal carcinoma.
Topics: Biomarkers, Tumor; Blotting, Western; Carcinoma; Cell Line, Tumor; Drug Resistance, Neoplasm; Female; Histones; Humans; Immunohistochemistry; Lysine; Male; Methylation; Middle Aged; Models, Biological; Multivariate Analysis; Nasopharyngeal Carcinoma; Nasopharyngeal Neoplasms; Neoplasm Metastasis; Predictive Value of Tests; Prognosis; Radiation Tolerance; ROC Curve; Survival Analysis; Treatment Outcome | 2011 |
An acetylation-mono-ubiquitination switch on lysine 120 of H2B.
Topics: Acetylation; Chromatin; Gene Expression Regulation; HCT116 Cells; Hep G2 Cells; Histones; Humans; Lysine; Methylation; Nucleosomes; Protein Processing, Post-Translational; Ubiquitin-Protein Ligases; Ubiquitination | 2011 |
Chromatin and transcriptional signatures for Nodal signaling during endoderm formation in hESCs.
Topics: Chromatin; Embryonic Stem Cells; Endoderm; Forkhead Transcription Factors; Gene Expression Profiling; Gene Expression Regulation, Developmental; Genome, Human; Histones; Humans; Jumonji Domain-Containing Histone Demethylases; Lysine; Methylation; Nodal Protein; Oligonucleotide Array Sequence Analysis; Organ Specificity; Protein Binding; Reproducibility of Results; Signal Transduction; Smad Proteins; Time Factors; Transcription, Genetic | 2011 |
Selective killing of mixed lineage leukemia cells by a potent small-molecule DOT1L inhibitor.
Topics: Animals; Cell Death; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Dose-Response Relationship, Drug; Enzyme Inhibitors; Gene Expression Profiling; Gene Expression Regulation, Leukemic; Gene Rearrangement; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; Leukemia, Biphenotypic, Acute; Lysine; Methylation; Methyltransferases; Mice; Myeloid-Lymphoid Leukemia Protein; Oncogene Proteins, Fusion; Small Molecule Libraries; Xenograft Model Antitumor Assays | 2011 |
MLL-rearranged leukemia is dependent on aberrant H3K79 methylation by DOT1L.
Topics: Animals; Apoptosis; Cell Cycle; Cell Differentiation; Cell Transformation, Neoplastic; Gene Rearrangement; Genetic Loci; Hematopoiesis; Histone-Lysine N-Methyltransferase; Histones; Homeodomain Proteins; Humans; Lysine; Methylation; Methyltransferases; Mice; Myeloid Ecotropic Viral Integration Site 1 Protein; Myeloid Progenitor Cells; Myeloid-Lymphoid Leukemia Protein; Neoplasm Proteins; Oncogene Proteins, Fusion; Protein Processing, Post-Translational | 2011 |
SPR-5 is a histone H3K4 demethylase with a role in meiotic double-strand break repair.
Topics: Animals; Animals, Genetically Modified; Antineoplastic Agents, Phytogenic; Apoptosis; Blotting, Western; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Camptothecin; DNA Breaks, Double-Stranded; DNA Repair; Gene Expression Profiling; Germ Cells; Green Fluorescent Proteins; Histones; Lysine; Meiosis; Methylation; Microscopy, Fluorescence; Mutation; Oligonucleotide Array Sequence Analysis; Oxidoreductases, N-Demethylating; Rad51 Recombinase; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference | 2011 |
Wolf-Hirschhorn syndrome candidate 1 is involved in the cellular response to DNA damage.
Topics: Cell Line, Tumor; Checkpoint Kinase 2; DNA Damage; DNA Replication; Enzyme Activation; Gene Silencing; Histone-Lysine N-Methyltransferase; Histones; Humans; Hydroxyurea; Intracellular Signaling Peptides and Proteins; Lysine; Methylation; Phosphorylation; Protein Serine-Threonine Kinases; Protein Transport; Replication Protein A; Repressor Proteins; Stress, Physiological; Tumor Suppressor p53-Binding Protein 1; Wolf-Hirschhorn Syndrome | 2011 |
Splicing enhances recruitment of methyltransferase HYPB/Setd2 and methylation of histone H3 Lys36.
Topics: Animals; Cell Line; Chromatin Immunoprecipitation; Epigenesis, Genetic; HeLa Cells; Histone-Lysine N-Methyltransferase; Histones; Humans; Introns; Lysine; Methylation; Mice; Models, Genetic; RNA Splicing; Sequence Analysis, RNA | 2011 |
Histone H3 trimethylation at lysine 36 is associated with constitutive and facultative heterochromatin.
Topics: Animals; Chromosomes, Mammalian; Epigenomics; Female; Gene Expression Regulation; Gene Silencing; Heterochromatin; Histones; Lysine; Male; Methylation; Mice; Mice, Inbred C57BL; Nuclear Proteins; Transcription, Genetic | 2011 |
Structural framework for the modulation of the activity of the hybrid antibiotic peptide cecropin A-melittin [CA(1-7)M(2-9)] by Nε-lysine trimethylation.
Topics: Amino Acid Sequence; Antimicrobial Cationic Peptides; Lysine; Magnetic Resonance Spectroscopy; Methylation; Micelles; Models, Molecular; Protein Conformation; Protein Stability; Sodium Dodecyl Sulfate; Structure-Activity Relationship | 2011 |
Histone crosstalk directed by H2B ubiquitination is required for chromatin boundary integrity.
Topics: Acetylation; Amino Acid Sequence; Animals; Avian Proteins; beta-Globins; Blotting, Western; Cell Line, Tumor; Chick Embryo; Chickens; Chromatin; Folate Receptor 1; Heterochromatin; Histone Code; Histones; Insulator Elements; Lysine; Methylation; Molecular Sequence Data; Protein Binding; Regulatory Sequences, Nucleic Acid; RNA Interference; RNA Polymerase II; Sequence Homology, Amino Acid; Ubiquitin-Protein Ligases; Ubiquitination | 2011 |
Stage-specific histone modification profiles reveal global transitions in the Xenopus embryonic epigenome.
Topics: Animals; Blastula; Blotting, Western; Cell Differentiation; Chromatography, Liquid; Embryo, Nonmammalian; Embryonic Stem Cells; Epigenomics; Gene Expression Profiling; Histones; Lysine; Methylation; Mice; Mice, Inbred ICR; Protein Processing, Post-Translational; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Xenopus laevis | 2011 |
Genome-wide epigenetic analysis of human pluripotent stem cells by ChIP and ChIP-Seq.
Topics: Animals; Chromatin; Chromatin Immunoprecipitation; DNA; Epigenesis, Genetic; Gene Library; Genome, Human; Histones; Humans; Lysine; Methylation; Mice; Organic Chemicals; Pluripotent Stem Cells; Polymerase Chain Reaction; Proteins; Sequence Analysis, DNA | 2011 |
Fasting of 3-day-old chicks leads to changes in histone H3 methylation status.
Topics: Animals; Animals, Newborn; Chickens; Corticotropin-Releasing Hormone; Fasting; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Hypothalamus; Iodide Peroxidase; Iodothyronine Deiodinase Type II; Lysine; Male; Methylation; RNA, Messenger; Thyrotropin-Releasing Hormone | 2012 |
Regulation of p53 function by lysine methylation.
Topics: Epigenesis, Genetic; Histocompatibility Antigens; Histone Demethylases; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Models, Biological; Signal Transduction; Tumor Suppressor Protein p53 | 2011 |
Pairing of lacO tandem repeats in Arabidopsis thaliana nuclei requires the presence of hypermethylated, large arrays at two chromosomal positions, but does not depend on H3-lysine-9-dimethylation.
Topics: Arabidopsis; Cell Nucleus; Chromosome Pairing; Chromosomes, Plant; DNA Methylation; Heterochromatin; Histones; Lysine; Methylation; Plant Proteins; Tandem Repeat Sequences | 2011 |
Recent transcription-induced histone H3 lysine 4 (H3K4) methylation inhibits gene reactivation.
Topics: Adenosine Triphosphatases; Epigenesis, Genetic; Fungal Proteins; Galactokinase; Galactose; Gene Deletion; Gene Expression Regulation, Fungal; Histones; Kinetics; Lysine; Methylation; RNA Polymerase II; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Transcription, Genetic | 2011 |
The Y641C mutation of EZH2 alters substrate specificity for histone H3 lysine 27 methylation states.
Topics: Animals; Base Sequence; Cell Line; Cysteine; DNA-Binding Proteins; Enhancer of Zeste Homolog 2 Protein; Histones; Humans; Lysine; Methylation; Molecular Sequence Data; Mutation; Polycomb Repressive Complex 2; Sequence Analysis, DNA; Substrate Specificity; Transcription Factors | 2011 |
High-throughput TR-FRET assays for identifying inhibitors of LSD1 and JMJD2C histone lysine demethylases.
Topics: Amino Acid Sequence; Enzyme Inhibitors; Fluorescence Resonance Energy Transfer; High-Throughput Screening Assays; Histone Demethylases; Immunoassay; Jumonji Domain-Containing Histone Demethylases; Lysine; Methylation; Molecular Sequence Data; Peptides | 2012 |
Effects of novel C-methylated spermidine analogs on cell growth via hypusination of eukaryotic translation initiation factor 5A.
Topics: Blotting, Western; Cell Division; Cell Line, Tumor; Eukaryotic Translation Initiation Factor 5A; Humans; Lysine; Male; Methylation; Peptide Initiation Factors; RNA-Binding Proteins; Spermidine | 2012 |
Coordinated methyl-lysine erasure: structural and functional linkage of a Jumonji demethylase domain and a reader domain.
Topics: 5-Methylcytosine; Cytosine; DNA; Histone Demethylases; Jumonji Domain-Containing Histone Demethylases; Lysine; Methylation; Structure-Activity Relationship | 2011 |
MAGE I transcription factors regulate KAP1 and KRAB domain zinc finger transcription factor mediated gene repression.
Topics: Antigens, Neoplasm; Binding Sites; DNA-Binding Proteins; Gene Expression Regulation; Genes, Reporter; HEK293 Cells; Histones; Humans; Inhibitor of Differentiation Protein 1; Lysine; Methylation; Models, Biological; Mutant Proteins; Neoplasm Proteins; Protein Binding; Protein Structure, Tertiary; Repressor Proteins; Reproducibility of Results; Transcription Factors; Tripartite Motif-Containing Protein 28; Ubiquitination; Zinc Fingers | 2011 |
Structure of human SMYD2 protein reveals the basis of p53 tumor suppressor methylation.
Topics: Calorimetry; Cell Line, Tumor; Crystallography, X-Ray; Genes, Tumor Suppressor; Histone-Lysine N-Methyltransferase; Histones; Humans; Kinetics; Lysine; Methylation; Molecular Conformation; Neoplasms; Protein Binding; Transcription, Genetic; Tumor Suppressor Protein p53 | 2011 |
Identification of protein methylation sites by coupling improved ant colony optimization algorithm and support vector machine.
Topics: Algorithms; Arginine; Databases, Protein; Lysine; Methylation; Proteins; Support Vector Machine | 2011 |
Histone modifications and expression of DAM6 gene in peach are modulated during bud dormancy release in a cultivar-dependent manner.
Topics: Abscisic Acid; Acetylation; Chromatin Immunoprecipitation; Ecotype; Expressed Sequence Tags; Flowers; Gene Expression Regulation, Plant; Genes, Plant; Histones; Lysine; Methylation; Models, Biological; Oligonucleotide Array Sequence Analysis; Plant Proteins; Principal Component Analysis; Protein Processing, Post-Translational; Prunus; Real-Time Polymerase Chain Reaction; Reproducibility of Results | 2012 |
The centromeric heterochromatin of Costus spiralis: poorly methylated and transiently acetylated during meiosis.
Topics: 5-Methylcytosine; Acetylation; Centromere; Chromatin; Chromosomes, Plant; Costus; Euchromatin; Fluorescent Dyes; Heterochromatin; Histones; Immunohistochemistry; Indoles; Lysine; Methylation; Pachytene Stage; Serine | 2011 |
Structural cooperativity in histone H3 tail modifications.
Topics: Acetylation; Animals; Histones; Humans; Lysine; Methylation; Models, Molecular; Protein Processing, Post-Translational | 2011 |
Structure-guided design of a methyl donor cofactor that controls a viral histone H3 lysine 27 methyltransferase activity.
Topics: Chlorella; Coenzymes; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Models, Molecular; Mutation; Paramecium; Protein Conformation; S-Adenosylhomocysteine; Stereoisomerism; Structure-Activity Relationship; Viral Proteins | 2011 |
Facile synthesis and altered ionization efficiency of diverse Nε-alkyllysine-containing peptides.
Topics: Lysine; Methylation; Molecular Structure; Peptides | 2012 |
Nucleolar protein Spindlin1 recognizes H3K4 methylation and stimulates the expression of rRNA genes.
Topics: Animals; Cell Cycle Proteins; Fibroblasts; Gene Expression Regulation; Genetic Loci; HeLa Cells; Histones; Humans; Lysine; Methylation; Mice; Microtubule-Associated Proteins; Multiprotein Complexes; Nuclear Proteins; Nucleophosmin; Phosphoproteins; Protein Binding; Protein Subunits; Protein Transport; Repetitive Sequences, Nucleic Acid; RNA, Ribosomal | 2011 |
Jumonji/ARID1 B (JARID1B) protein promotes breast tumor cell cycle progression through epigenetic repression of microRNA let-7e.
Topics: Breast Neoplasms; Cell Cycle; Cell Line, Tumor; Cyclin D1; Epigenesis, Genetic; Female; Gene Silencing; Histones; Humans; Jumonji Domain-Containing Histone Demethylases; Lysine; Methylation; MicroRNAs; Nuclear Proteins; Repressor Proteins | 2011 |
Quantitative assessment of protein interaction with methyl-lysine analogues by hybrid computational and experimental approaches.
Topics: Binding Sites; Computer Simulation; Cysteine; Escherichia coli; Ligands; Lysine; Methylation; Models, Molecular; Molecular Mimicry; Peptides; Protein Binding; Protein Structure, Tertiary; Recombinant Proteins; Thermodynamics | 2012 |
Regulation of DCC localization by HTZ-1/H2A.Z and DPY-30 does not correlate with H3K4 methylation levels.
Topics: Animals; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Chromatin; Dosage Compensation, Genetic; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Lysine; Male; Methylation; Nuclear Proteins; X Chromosome | 2011 |
Corepressor protein CDYL functions as a molecular bridge between polycomb repressor complex 2 and repressive chromatin mark trimethylated histone lysine 27.
Topics: Animals; Catalytic Domain; Cell Line, Tumor; Chromatin; Co-Repressor Proteins; Epigenesis, Genetic; Gene Expression Regulation; Histones; Humans; Hydro-Lyases; Lysine; Methylation; Methyltransferases; Nucleosomes; Polycomb-Group Proteins; Proteins; Repressor Proteins; Xenopus | 2011 |
The ability of MLL to bind RUNX1 and methylate H3K4 at PU.1 regulatory regions is impaired by MDS/AML-associated RUNX1/AML1 mutations.
Topics: Acute Disease; Blotting, Western; Cell Line; Cell Line, Tumor; Chromatin Immunoprecipitation; Core Binding Factor Alpha 2 Subunit; Core Binding Factor beta Subunit; Gene Expression; HEK293 Cells; Histone-Lysine N-Methyltransferase; Histones; Humans; Leukemia, Myeloid; Lysine; Methylation; Mutation; Myelodysplastic Syndromes; Myeloid-Lymphoid Leukemia Protein; Protein Binding; Proto-Oncogene Proteins; Regulatory Sequences, Nucleic Acid; Reverse Transcriptase Polymerase Chain Reaction; Trans-Activators | 2011 |
Structural basis for specific binding of human MPP8 chromodomain to histone H3 methylated at lysine 9.
Topics: Amino Acid Sequence; Chromosomal Proteins, Non-Histone; Crystallography, X-Ray; DNA Methyltransferase 3A; Drosophila Proteins; Histones; Humans; Lysine; Methylation; Models, Molecular; Molecular Sequence Data; Peptides; Phosphoproteins; Polycomb-Group Proteins; Protein Binding; Protein Structure, Tertiary; Repressor Proteins; Structural Homology, Protein; Structure-Activity Relationship | 2011 |
Proteomic analyses of the SMYD family interactomes identify HSP90 as a novel target for SMYD2.
Topics: HEK293 Cells; Histone Demethylases; Histone-Lysine N-Methyltransferase; HSP90 Heat-Shock Proteins; Humans; Isoenzymes; Lysine; Methylation; Models, Molecular; Multiprotein Complexes; Protein Conformation; Protein Interaction Maps; Proteome | 2011 |
Tumor suppressor protein p53 recruits human Sin3B/HDAC1 complex for down-regulation of its target promoters in response to genotoxic stress.
Topics: Animals; Cell Cycle Proteins; Cell Line, Tumor; DNA Damage; Down-Regulation; Doxorubicin; Gene Silencing; Histone Deacetylase 1; Histones; HSC70 Heat-Shock Proteins; Humans; Lysine; Methylation; Mice; Nuclear Proteins; Phosphorylation; Promoter Regions, Genetic; Protein Structure, Tertiary; Repressor Proteins; Tumor Suppressor Protein p53; zeta-Crystallins | 2011 |
Dual modification of Alzheimer's disease PHF-tau protein by lysine methylation and ubiquitylation: a mass spectrometry approach.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Amino Acid Sequence; Female; Humans; Lysine; Male; Methylation; Middle Aged; Molecular Sequence Data; Neurofibrillary Tangles; Phosphorylation; Protein Processing, Post-Translational; Tandem Mass Spectrometry; tau Proteins; Ubiquitination | 2012 |
Tuning HP1α chromodomain selectivity for di- and trimethyllysine.
Topics: Animals; Circular Dichroism; Drosophila; Fluorescence Polarization; Histones; Lysine; Methylation; Models, Molecular | 2011 |
A model for mitotic inheritance of histone lysine methylation.
Topics: Cell Cycle; Cell Cycle Checkpoints; Epigenesis, Genetic; HeLa Cells; Histones; Humans; Hydroxyurea; Lysine; Methylation; Mitosis; Models, Biological | 2011 |
A bacteria colony-based screen for optimal linker combinations in genetically encoded biosensors.
Topics: Amino Acid Sequence; Animals; Biosensing Techniques; Escherichia coli; Fluorescence Resonance Energy Transfer; Fluorescent Dyes; High-Throughput Screening Assays; Histones; Lysine; Methylation; Mice; Models, Molecular; Molecular Probe Techniques; Molecular Probes; Molecular Sequence Data; Peptide Library; Small Molecule Libraries | 2011 |
The global histone modification pattern correlates with overall survival in metachronous liver metastasis of colorectal cancer.
Topics: Acetylation; Colorectal Neoplasms; Female; Histones; Humans; Immunohistochemistry; Liver Neoplasms; Lysine; Male; Methylation; Middle Aged; Neoplasms, Second Primary; Prognosis; Protein Processing, Post-Translational; Retrospective Studies; Survival Rate | 2012 |
Recognition of enhancer element-specific histone methylation by TIP60 in transcriptional activation.
Topics: Amino Acid Sequence; Cell Line; Chromatin Assembly and Disassembly; DNA Helicases; Enhancer Elements, Genetic; Estrogen Receptor alpha; Estrogens; Histone Acetyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Lysine Acetyltransferase 5; Methylation; Molecular Sequence Data; Myeloid-Lymphoid Leukemia Protein; Nuclear Proteins; Protein Interaction Mapping; Sequence Alignment; Transcription Factors; Transcriptional Activation | 2011 |
A cell-based high-throughput screening assay to measure cellular histone h3 lys27 trimethylation with a modified dissociation-enhanced lanthanide fluorescent immunoassay.
Topics: Cell Line, Tumor; Cell Survival; Dose-Response Relationship, Drug; Enzyme Inhibitors; Fluorescent Antibody Technique; High-Throughput Screening Assays; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; Lanthanoid Series Elements; Lysine; Male; Methylation; Prostatic Neoplasms | 2012 |
NSD2 links dimethylation of histone H3 at lysine 36 to oncogenic programming.
Topics: Animals; Cell Transformation, Neoplastic; Chromatin; Gene Expression Profiling; Gene Expression Regulation; Genome-Wide Association Study; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Mice; Mice, SCID; Multiple Myeloma; Recombinant Proteins; Repressor Proteins; Signal Transduction; Transcription, Genetic; Translocation, Genetic; Xenograft Model Antitumor Assays | 2011 |
Nuclear RNAi maintains heritable gene silencing in Caenorhabditis elegans.
Topics: Animals; Animals, Genetically Modified; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Cell Nucleus; Female; Gene Expression Regulation, Developmental; Green Fluorescent Proteins; Histones; Inheritance Patterns; Lysine; Male; Methylation; Microscopy, Fluorescence; Mutation; Recombinant Fusion Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; RNA-Binding Proteins; RNA, Small Interfering | 2011 |
Clustered ChIP-Seq-defined transcription factor binding sites and histone modifications map distinct classes of regulatory elements.
Topics: Binding Sites; Cell Line; Chromatin; Chromatin Immunoprecipitation; High-Throughput Nucleotide Sequencing; Histones; Humans; Lysine; Methylation; Multigene Family; Protein Binding; Regulatory Sequences, Nucleic Acid; Transcription Factors | 2011 |
Global mapping of H3K4me1 and H3K4me3 reveals the chromatin state-based cell type-specific gene regulation in human Treg cells.
Topics: CD4 Antigens; Cell Lineage; Cell Proliferation; Cell Separation; Chromatin; Chromatin Immunoprecipitation; Enhancer Elements, Genetic; Forkhead Transcription Factors; Gene Expression Regulation; Genome, Human; Histones; Humans; Interleukin-2 Receptor alpha Subunit; Lysine; Methylation; Organ Specificity; Promoter Regions, Genetic; Protein Processing, Post-Translational; Reproducibility of Results; Sequence Analysis, DNA; T-Lymphocytes, Regulatory | 2011 |
H3K36 methylation is critical for brassinosteroid-regulated plant growth and development in rice.
Topics: Brassinosteroids; Chromatin Immunoprecipitation; Gene Expression Profiling; Gene Expression Regulation, Plant; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Luminescent Proteins; Lysine; Methylation; Microscopy, Confocal; Oligonucleotide Array Sequence Analysis; Oryza; Plant Growth Regulators; Plant Proteins; Protein Binding; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference | 2012 |
X-chromosome hyperactivation in mammals via nonlinear relationships between chromatin states and transcription.
Topics: Animals; Cell Line; Chromatin; Chromosomes, Mammalian; DNA Polymerase II; Dosage Compensation, Genetic; Female; Gene Expression Profiling; Genes, X-Linked; Histones; Lysine; Male; Methylation; Mice; Mice, 129 Strain; Models, Genetic; Oligonucleotide Array Sequence Analysis; Promoter Regions, Genetic; Transcription Initiation Site; Transcription, Genetic; X Chromosome | 2011 |
Dual function of histone H3 lysine 36 methyltransferase ASH1 in regulation of Hox gene expression.
Topics: Biocatalysis; DNA-Binding Proteins; Gene Expression Regulation, Leukemic; Gene Knockdown Techniques; HeLa Cells; Hematopoiesis; Histone-Lysine N-Methyltransferase; Histones; Homeodomain Proteins; Humans; K562 Cells; Lysine; Methylation; Myeloid-Lymphoid Leukemia Protein; Promoter Regions, Genetic; Protein Binding; Repressor Proteins; Transcription Factors | 2011 |
Quantification of protein isoforms in mesenchymal stem cells by reductive dimethylation of lysines in intact proteins.
Topics: Animals; Cells, Cultured; Cytoplasm; Gene Expression; Isotope Labeling; Lysine; Mass Spectrometry; Mesenchymal Stem Cells; Methylation; Mice; Nuclear Proteins; Protein Isoforms; Stromal Cells | 2012 |
Druggability of methyl-lysine binding sites.
Topics: Binding Sites; Drug Design; Histones; Humans; Lysine; Methylation; Models, Molecular; Protein Structure, Tertiary; Small Molecule Libraries | 2011 |
Solution structure of the Pdp1 PWWP domain reveals its unique binding sites for methylated H4K20 and DNA.
Topics: Amino Acid Motifs; Amino Acid Sequence; Binding Sites; DNA; Electrophoretic Mobility Shift Assay; Histones; Lysine; Methylation; Models, Molecular; Molecular Sequence Data; Protein Conformation; Protein Structure, Tertiary; Schizosaccharomyces; Schizosaccharomyces pombe Proteins; Solutions | 2012 |
Interaction between γ-radiation and dietary folate starvation metabolically reprograms global hepatic histone H3 methylation at lysine 4 and lysine 27 residues.
Topics: Animals; Enzyme Induction; Folic Acid; Gamma Rays; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Liver; Lysine; Male; Methylation; Mice | 2012 |
Comparative epigenetic analysis of Oct4 regulatory region in RA-induced differentiated NT2 cells under adherent and non-adherent culture conditions.
Topics: Acetylation; Carcinoma, Embryonal; Cell Adhesion; Cell Culture Techniques; Cell Differentiation; Cell Line, Tumor; Chromatin Immunoprecipitation; Down-Regulation; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Histones; Humans; Lysine; Methylation; Octamer Transcription Factor-3; Real-Time Polymerase Chain Reaction; Regulatory Sequences, Nucleic Acid; Time Factors; Tretinoin | 2012 |
Bioinformatic analysis and post-translational modification crosstalk prediction of lysine acetylation.
Topics: Acetylation; Animals; Cell Cycle; Computational Biology; DNA Repair; Gene Expression Regulation; Humans; Lysine; Methylation; Mice; Models, Biological; Phosphorylation; Protein Conformation; Protein Processing, Post-Translational; Protein Structure, Secondary; Protein Structure, Tertiary; Proteomics; Ubiquitin | 2011 |
GmPHD5 acts as an important regulator for crosstalk between histone H3K4 di-methylation and H3K14 acetylation in response to salinity stress in soybean.
Topics: Acetylation; Cloning, Molecular; Gene Expression Regulation, Plant; Glycine max; Histones; Homeodomain Proteins; Lysine; Methylation; Protein Processing, Post-Translational; Salinity; Soybean Proteins; Stress, Physiological | 2011 |
Minimization of side reactions during Lys Tag derivatization of C-terminal lysine peptides.
Topics: Chromatography, High Pressure Liquid; Databases, Protein; Hydrogen-Ion Concentration; Hydrolysis; Imidazoles; Lysine; Methylation; Nanotechnology; Peptides; Proteomics; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Temperature | 2012 |
Deficiency of H3K79 histone methyltransferase Dot1-like protein (DOT1L) inhibits cell proliferation.
Topics: Cell Line, Tumor; Cell Proliferation; Chromosomal Instability; G1 Phase Cell Cycle Checkpoints; Gene Knockdown Techniques; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Methyltransferases; RNA, Small Interfering | 2012 |
Lysine methyltransferase G9a methylates the transcription factor MyoD and regulates skeletal muscle differentiation.
Topics: Amino Acid Sequence; Animals; Cell Differentiation; Cell Line; Histone-Lysine N-Methyltransferase; Humans; Lysine; Methylation; Mice; Molecular Sequence Data; Muscle Development; Muscle, Skeletal; MyoD Protein; Protein Binding | 2012 |
Compensatory functions of histone deacetylase 1 (HDAC1) and HDAC2 regulate transcription and apoptosis during mouse oocyte development.
Topics: Acetylation; Animals; Apoptosis; DNA-Binding Proteins; Female; Gene Deletion; Gene Expression Regulation, Developmental; Gene Targeting; Histone Deacetylase 1; Histone Deacetylase 2; Histones; Hydroxamic Acids; Infertility, Female; Jumonji Domain-Containing Histone Demethylases; Lysine; Methylation; Mice; Oocytes; Oogenesis; Organ Size; Ovarian Follicle; RNA Interference; RNA, Messenger; Transcription, Genetic; Transcriptome; Tumor Suppressor Protein p53 | 2012 |
RNA polymerase II phosphorylation at serine 2 and histone H3 tri-methylation at lysine 36 are key steps for thyroid hormone receptor β gene activation by thyroid hormone in Rana catesbeiana tadpole liver.
Topics: Animals; Gene Expression Regulation, Developmental; Histones; Larva; Liver; Lysine; Methylation; Rana catesbeiana; RNA Polymerase II; Serine; Thyroid Hormone Receptors beta; Transcriptional Activation; Triiodothyronine | 2012 |
Amplification of siRNA in Caenorhabditis elegans generates a transgenerational sequence-targeted histone H3 lysine 9 methylation footprint.
Topics: Animals; Base Sequence; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Chromatin; Gene Expression Profiling; Genetic Loci; Histones; Lysine; Methylation; Molecular Sequence Data; RNA, Double-Stranded; RNA, Small Interfering; Sequence Analysis, DNA | 2012 |
Smyd2 controls cytoplasmic lysine methylation of Hsp90 and myofilament organization.
Topics: Animals; Chick Embryo; Connectin; Cytoplasm; Histone-Lysine N-Methyltransferase; HSP90 Heat-Shock Proteins; Humans; Lysine; Methylation; Muscle Proteins; Muscle, Skeletal; Myocardium; Myofibrils; Protein Kinases; Recombinant Proteins; Zebrafish | 2012 |
Amyloid fibrillation in native and chemically-modified forms of carbonic anhydrase II: role of surface hydrophobicity.
Topics: Acetylation; Amyloid; Animals; Apoenzymes; Carbonic Anhydrase II; Cattle; Cell Survival; Circular Dichroism; Holoenzymes; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kinetics; Lysine; Methylation; PC12 Cells; Protein Folding; Rats; Solutions; Static Electricity; Temperature | 2012 |
Polycomb repressive complex 2 targets murine cytomegalovirus chromatin for modification and associates with viral replication centers.
Topics: Blotting, Western; Cell Line; Chromatin; Embryo, Mammalian; Enhancer of Zeste Homolog 2 Protein; Fibroblasts; Fluorescent Antibody Technique; Histone-Lysine N-Methyltransferase; Histones; Host-Pathogen Interactions; Lysine; Methylation; Muromegalovirus; Polycomb Repressive Complex 2; Polycomb-Group Proteins; Protein Binding; Repressor Proteins; Time Factors; Virus Replication | 2012 |
Methylation of nuclear proteins of Novikoff hepatoma.
Topics: Animals; Cell Nucleus; Histones; Kinetics; Liver; Liver Neoplasms, Experimental; Lysine; Male; Methylation; Nuclear Proteins; Rats; Rats, Sprague-Dawley; S-Adenosylmethionine | 1980 |
Jumonji domain-containing protein 3 regulates histone 3 lysine 27 methylation during bovine preimplantation development.
Topics: Animals; Blastocyst; Cattle; Histones; Jumonji Domain-Containing Histone Demethylases; Lysine; Methylation | 2012 |
CpG array analysis of histone H3 lysine 4 trimethylation by chromatin immunoprecipitation linked to microarrays analysis in peripheral blood mononuclear cells of IgA nephropathy patients.
Topics: Adult; Case-Control Studies; Chromatin Immunoprecipitation; Female; Glomerulonephritis, IGA; Histones; Humans; Leukocytes, Mononuclear; Lysine; Male; Methylation; Oligonucleotide Array Sequence Analysis; Real-Time Polymerase Chain Reaction; Young Adult | 2012 |
Mutation of A677 in histone methyltransferase EZH2 in human B-cell lymphoma promotes hypertrimethylation of histone H3 on lysine 27 (H3K27).
Topics: Alanine; Amino Acid Sequence; Base Sequence; Binding Sites; Cell Line, Tumor; DNA Mutational Analysis; DNA-Binding Proteins; Enhancer of Zeste Homolog 2 Protein; Gene Expression Regulation, Neoplastic; Glycine; Heterozygote; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; Lymphoma, B-Cell; Lysine; Methylation; Molecular Sequence Data; Mutant Proteins; Mutation; Polycomb Repressive Complex 2; Substrate Specificity; Transcription Factors | 2012 |
Methylation of H4 lysines 5, 8 and 12 by yeast Set5 calibrates chromatin stress responses.
Topics: Calibration; Chromatin; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Saccharomyces cerevisiae; Stress, Physiological | 2012 |
Azalysine analogues as probes for protein lysine deacetylation and demethylation.
Topics: Acetylation; Aza Compounds; Fluorescent Dyes; Histone Deacetylases; Histone Demethylases; Lysine; Methylation; Molecular Structure; Peptides | 2012 |
RNF8- and RNF168-dependent degradation of KDM4A/JMJD2A triggers 53BP1 recruitment to DNA damage sites.
Topics: Amino Acid Sequence; Cell Line; DNA; DNA Damage; DNA Repair; DNA-Binding Proteins; Histones; Humans; Intracellular Signaling Peptides and Proteins; Jumonji Domain-Containing Histone Demethylases; Lysine; Methylation; Models, Biological; Molecular Sequence Data; Protein Binding; Signal Transduction; Tumor Suppressor p53-Binding Protein 1; Ubiquitin-Protein Ligases | 2012 |
Histone H3 lysine 56 methylation regulates DNA replication through its interaction with PCNA.
Topics: DNA Replication; G1 Phase; HEK293 Cells; HeLa Cells; Histones; Humans; Lysine; Methylation; Nucleosomes; Proliferating Cell Nuclear Antigen; Protein Processing, Post-Translational | 2012 |
The BAH domain of ORC1 links H4K20me2 to DNA replication licensing and Meier-Gorlin syndrome.
Topics: Animals; Carrier Proteins; Cell Cycle; Cell Line; Chromatin; Congenital Microtia; Crystallography, X-Ray; Disease Models, Animal; DNA Replication; Dwarfism; Ear; Growth Disorders; Histones; Humans; Lysine; Methylation; Micrognathism; Models, Molecular; Origin Recognition Complex; Patella; Protein Structure, Tertiary; Replication Origin; Zebrafish; Zebrafish Proteins | 2012 |
A short Gfi-1B isoform controls erythroid differentiation by recruiting the LSD1-CoREST complex through the dimethylation of its SNAG domain.
Topics: Alternative Splicing; Amino Acid Motifs; Cell Line; Co-Repressor Proteins; Erythropoiesis; Erythropoietin; Gene Expression Regulation, Developmental; Histone Demethylases; Humans; Lysine; Methylation; Molecular Weight; Nerve Tissue Proteins; Promoter Regions, Genetic; Protein Binding; Protein Isoforms; Protein Structure, Tertiary; Proto-Oncogene Proteins; Repressor Proteins; Zinc Fingers | 2012 |
Lysine methylation of FOXO3 regulates oxidative stress-induced neuronal cell death.
Topics: Amino Acid Sequence; Animals; Cell Death; DNA; Forkhead Box Protein O3; Forkhead Transcription Factors; Histone-Lysine N-Methyltransferase; Humans; Lysine; Methylation; Mice; Molecular Sequence Data; Neurons; Oxidative Stress; Protein Binding; Transcription, Genetic | 2012 |
PLMLA: prediction of lysine methylation and lysine acetylation by combining multiple features.
Topics: Acetylation; Algorithms; Amino Acid Sequence; Computational Biology; Databases, Protein; Internet; Lysine; Methylation; Models, Molecular; Molecular Sequence Data; Protein Structure, Secondary; Proteins | 2012 |
Smyd3 regulates cancer cell phenotypes and catalyzes histone H4 lysine 5 methylation.
Topics: Animals; Blotting, Western; Chromatin; Enzyme Activation; Fibroblasts; Gene Expression Regulation, Neoplastic; Genetic Complementation Test; HeLa Cells; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Mice; Mice, Inbred C57BL; Mice, Knockout; Mutagenesis, Site-Directed; Peptide Library; Phenotype; Plasmids; Recombinant Proteins; RNA, Small Interfering; Substrate Specificity | 2012 |
Maternal low-protein diet causes epigenetic deregulation of HMGCR and CYP7α1 in the liver of weaning piglets.
Topics: 3' Untranslated Regions; Animals; Body Weight; Cholesterol; Cholesterol 7-alpha-Hydroxylase; Diet, Protein-Restricted; Epigenesis, Genetic; Female; Gene Expression Regulation, Developmental; Histones; Hydroxymethylglutaryl CoA Reductases; Lactation; Liver; Lysine; Maternal Nutritional Physiological Phenomena; Methylation; MicroRNAs; Organ Size; Pregnancy; Prenatal Exposure Delayed Effects; Promoter Regions, Genetic; Receptors, LDL; Sterol Regulatory Element Binding Protein 2; Swine; Weaning | 2012 |
Maturation-related histone modifications in the PU.1 promoter regulate Th9-cell development.
Topics: Adult; CD4-Positive T-Lymphocytes; Cell Differentiation; Cells, Cultured; Epigenesis, Genetic; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; Infant, Newborn; Interleukin-9; Lysine; Methylation; Promoter Regions, Genetic; Protein Processing, Post-Translational; Proto-Oncogene Proteins; T-Lymphocytes, Helper-Inducer; Trans-Activators | 2012 |
CHD3 protein recognizes and regulates methylated histone H3 lysines 4 and 27 over a subset of targets in the rice genome.
Topics: Amino Acid Sequence; Down-Regulation; Gene Expression Regulation, Plant; Genes, Plant; Genome, Plant; Histones; Lysine; Methylation; Molecular Sequence Data; Mutation; Oryza; Phenotype; Plant Proteins; Protein Binding; Protein Structure, Tertiary; Repressor Proteins; Transcription Factors | 2012 |
The CHD3 remodeler PICKLE associates with genes enriched for trimethylation of histone H3 lysine 27.
Topics: Actins; Arabidopsis; Arabidopsis Proteins; Chromatin Assembly and Disassembly; Chromatin Immunoprecipitation; DNA Helicases; Gene Expression Regulation, Developmental; Gene Expression Regulation, Plant; Genes, Plant; Genetic Loci; Germination; Histones; Lysine; Methylation; Plant Leaves; Plant Shoots; Polycomb Repressive Complex 2; Polyubiquitin; Repressor Proteins; Seeds | 2012 |
Gene expression profile in the liver of Rana catesbeiana tadpoles exposed to low temperature in the presence of thyroid hormone.
Topics: Acetylation; Animals; Body Temperature Regulation; CCAAT-Enhancer-Binding Proteins; Chromatin; Cold Temperature; Gene Expression Profiling; Histones; Larva; Liver; Lysine; Methylation; Rana catesbeiana; Thyroid Hormone Receptors beta; Transcriptional Activation; Triiodothyronine | 2012 |
Mallory-Denk bodies form when EZH2/H3K27me3 fails to methylate DNA in the nuclei of human and mice liver cells.
Topics: Animals; Blotting, Western; Carcinoma, Hepatocellular; Cell Cycle Checkpoints; Cell Nucleus; Cyclin D1; Cyclin-Dependent Kinase Inhibitor p27; DNA Methylation; DNA-Binding Proteins; Enhancer of Zeste Homolog 2 Protein; Hepatitis, Alcoholic; Hepatocytes; Histones; Humans; Immunohistochemistry; Liver; Liver Neoplasms; Lysine; Mallory Bodies; Methylation; Mice; Microscopy, Electron; Polycomb Repressive Complex 2; Proliferating Cell Nuclear Antigen; Pyridines; Reverse Transcriptase Polymerase Chain Reaction; S-Adenosylmethionine; Transcription Factors | 2012 |
Yin Yang 1 deficiency in skeletal muscle protects against rapamycin-induced diabetic-like symptoms through activation of insulin/IGF signaling.
Topics: Animals; Diabetes Mellitus, Experimental; Enhancer of Zeste Homolog 2 Protein; Gene Expression Regulation; Histone-Lysine N-Methyltransferase; Histones; Humans; Insulin; Insulin Resistance; Insulin-Like Growth Factor I; Lipid Metabolism; Liver; Lysine; Methylation; Mice; Mice, Knockout; Models, Biological; Muscle, Skeletal; Organ Specificity; Polycomb Repressive Complex 2; Polycomb-Group Proteins; Promoter Regions, Genetic; Protein Binding; Repressor Proteins; Signal Transduction; Sirolimus; YY1 Transcription Factor | 2012 |
Lysyl oxidase-like 2 deaminates lysine 4 in histone H3.
Topics: Amino Acid Oxidoreductases; Antigens, CD; Cadherins; Cell Line, Tumor; Deamination; Gene Expression Regulation; Histones; Humans; Lysine; Methylation | 2012 |
Significance of calcium binding, tyrosine phosphorylation, and lysine trimethylation for the essential function of calmodulin in vertebrate cells analyzed in a novel gene replacement system.
Topics: Animals; Calcium; Calmodulin; Cell Line; Chickens; Gene Deletion; Lysine; Methylation; Phosphorylation; Protein Binding; Tyrosine | 2012 |
Transition of chromatin status during the process of recovery from drought stress in Arabidopsis thaliana.
Topics: Acetylation; Arabidopsis; Arabidopsis Proteins; Chromatin; Chromatin Immunoprecipitation; Droughts; Gene Expression Regulation, Plant; Gene Silencing; Genes, Plant; Histones; Lysine; Methylation; Models, Biological; Nucleosomes; RNA Polymerase II; RNA, Messenger; Stress, Physiological | 2012 |
Site-specific mapping and time-resolved monitoring of lysine methylation by high-resolution NMR spectroscopy.
Topics: Acetylation; HeLa Cells; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Magnetic Resonance Spectroscopy; Methylation; Nuclear Magnetic Resonance, Biomolecular; Protein Processing, Post-Translational | 2012 |
Binding of the three-repeat domain of tau to phospholipid membranes induces an aggregated-like state of the protein.
Topics: Alzheimer Disease; Amino Acid Sequence; Benzothiazoles; Biophysics; Circular Dichroism; Humans; Lipid Bilayers; Lipids; Liposomes; Lysine; Magnetic Resonance Spectroscopy; Methylation; Molecular Sequence Data; Phosphatidylcholines; Phosphatidylserines; Phospholipids; Protein Binding; Protein Conformation; Protein Structure, Secondary; Protein Structure, Tertiary; Static Electricity; tau Proteins; Thiazoles; Unilamellar Liposomes | 2012 |
Methylation of translation-associated proteins in Saccharomyces cerevisiae: Identification of methylated lysines and their methyltransferases.
Topics: Amino Acid Sequence; Chromatography, Affinity; Humans; Lysine; Methylation; Methyltransferases; Molecular Sequence Data; Peptide Elongation Factors; Proteome; Proteomics; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sequence Alignment; Tandem Mass Spectrometry | 2012 |
Methylation of FoxO3 regulates neuronal cell death.
Topics: Animals; Apoptosis; Forkhead Box Protein O3; Forkhead Transcription Factors; Gene Expression Regulation; Histone-Lysine N-Methyltransferase; Lysine; Methylation; Neurons; Oxidative Stress; Protein Processing, Post-Translational; Transcription, Genetic | 2012 |
Histone lysine methyltransferase SETD8 promotes carcinogenesis by deregulating PCNA expression.
Topics: Aged; Cell Line, Tumor; Cell Transformation, Neoplastic; DNA Damage; DNA Replication; Female; Histone-Lysine N-Methyltransferase; Humans; Lysine; Male; Methylation; Middle Aged; Proliferating Cell Nuclear Antigen; Real-Time Polymerase Chain Reaction; RNA, Small Interfering | 2012 |
Comparative expression analysis of the H3K27 demethylases, JMJD3 and UTX, with the H3K27 methylase, EZH2, in Xenopus.
Topics: Amino Acid Sequence; Animals; Chlorocebus aethiops; COS Cells; Embryo, Nonmammalian; Gene Expression Regulation, Developmental; Green Fluorescent Proteins; Histone-Lysine N-Methyltransferase; Histones; In Situ Hybridization; Jumonji Domain-Containing Histone Demethylases; Lysine; Methylation; Microscopy, Confocal; Molecular Sequence Data; Phylogeny; Reverse Transcriptase Polymerase Chain Reaction; Sequence Homology, Amino Acid; Xenopus; Xenopus Proteins | 2012 |
Epigenetic reprogramming of embryos derived from sperm frozen at -20°C.
Topics: Animals; Blastocyst; Cryopreservation; DNA Methylation; Embryo, Mammalian; Embryonic Development; Epigenesis, Genetic; Female; Fertilization in Vitro; Fluorescent Antibody Technique; Histones; Humans; Karyotyping; Lysine; Male; Methylation; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Sperm Injections, Intracytoplasmic; Spermatozoa; Time Factors | 2012 |
The SET8 H4K20 protein lysine methyltransferase has a long recognition sequence covering seven amino acid residues.
Topics: Amino Acid Motifs; Amino Acid Sequence; HEK293 Cells; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Models, Molecular; Molecular Sequence Data; Peptide Fragments; Protein Unfolding; Tumor Suppressor Protein p53 | 2012 |
Dynamic acetylation of lysine-4-trimethylated histone H3 and H3 variant biology in a simple multicellular eukaryote.
Topics: Acetylation; Amino Acid Substitution; Dictyostelium; Gene Deletion; Gene Expression; Histone-Lysine N-Methyltransferase; Histones; Hydroxamic Acids; Lysine; Methylation | 2012 |
Histone monoubiquitylation position determines specificity and direction of enzymatic cross-talk with histone methyltransferases Dot1L and PRC2.
Topics: Animals; Blotting, Western; Electrophoresis, Polyacrylamide Gel; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Methyltransferases; Models, Molecular; Mutation; Nucleosomes; Protein Binding; Protein Structure, Tertiary; Ubiquitination; Xenopus laevis | 2012 |
PHD finger of the SUMO ligase Siz/PIAS family in rice reveals specific binding for methylated histone H3 at lysine 4 and arginine 2.
Topics: Arginine; Binding Sites; Histones; Ligases; Lysine; Methylation; Models, Molecular; Oryza; Plant Proteins; Protein Conformation; Sumoylation | 2012 |
Cortical spreading depression differentially affects lysine methylation of H3 histone at neuroprotective genes and retrotransposon sequences.
Topics: Animals; Cell Nucleus; Centrifugation, Density Gradient; Chloral Hydrate; Chromatin Immunoprecipitation; Cortical Spreading Depression; Histones; Hypnotics and Sedatives; Hypoxia-Inducible Factor 1; Lysine; Male; Methylation; Nitric Oxide Synthase Type II; Rats; Rats, Wistar; Real-Time Polymerase Chain Reaction; Retroelements | 2012 |
New marks on the block: Set5 methylates H4 lysines 5, 8 and 12.
Topics: Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Saccharomyces cerevisiae | 2012 |
A facile method to synthesize histones with posttranslational modification mimics.
Topics: Acetylation; Histones; Immunoprecipitation; Lysine; Methylation; Molecular Structure; Phosphorylation; Protein Processing, Post-Translational; Serine | 2012 |
Vitrification of pig oocytes induces changes in histone H4 acetylation and histone H3 lysine 9 methylation (H3K9).
Topics: Acetylation; Animals; Chromatin; Cryopreservation; Epigenesis, Genetic; Female; Fluorescent Antibody Technique; Histones; Lysine; Methylation; Oocytes; Swine; Vitrification | 2012 |
High levels of glucose induce "metabolic memory" in cardiomyocyte via epigenetic histone H3 lysine 9 methylation.
Topics: Cell Line; Cells, Cultured; Cytokines; Epigenesis, Genetic; Gene Expression Regulation; Glucose; Histones; Humans; Inflammation; Inflammation Mediators; Interleukin-6; Lysine; Methylation; Myocytes, Cardiac; Promoter Regions, Genetic | 2012 |
Global levels of H3K27me3 track with differentiation in vivo and are deregulated by MYC in prostate cancer.
Topics: Animals; Cell Compartmentation; Cell Differentiation; Cell Line, Tumor; Enhancer of Zeste Homolog 2 Protein; Histones; Humans; Immunohistochemistry; Inflammation; Lysine; Male; Methylation; Mice; Organ Specificity; Polycomb Repressive Complex 2; Prostate; Prostatectomy; Prostatic Neoplasms; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-myc; RNA, Small Interfering; Stem Cells; Tissue Array Analysis | 2012 |
The histone H3 Lys 27 demethylase JMJD3 regulates gene expression by impacting transcriptional elongation.
Topics: Binding Sites; Cell Cycle Proteins; Cell Differentiation; Gene Expression Regulation, Neoplastic; Histones; HL-60 Cells; Humans; Jumonji Domain-Containing Histone Demethylases; Lysine; Macrophages; Methylation; Models, Biological; Phenotype; RNA Polymerase II; Tetradecanoylphorbol Acetate; Transcription Factors; Transcription, Genetic | 2012 |
Histone H3R2 symmetric dimethylation and histone H3K4 trimethylation are tightly correlated in eukaryotic genomes.
Topics: Animals; Arginine; Conserved Sequence; Eukaryota; Evolution, Molecular; Genetic Loci; Genome; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Mice; Receptors, Antigen; Recombination, Genetic; RNA, Small Interfering; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins | 2012 |
PGC7 binds histone H3K9me2 to protect against conversion of 5mC to 5hmC in early embryos.
Topics: 5-Methylcytosine; Animals; Chromatin; Chromosomal Proteins, Non-Histone; Cytosine; Dioxygenases; DNA Methylation; DNA-Binding Proteins; Embryo, Mammalian; Embryonic Development; Female; Genomic Imprinting; Histones; Lysine; Male; Methylation; Mice; Protein Binding; Proto-Oncogene Proteins; ras-GRF1; Repressor Proteins; RNA, Long Noncoding; RNA, Untranslated; Spermatozoa | 2012 |
Embryonic stem cell potency fluctuates with endogenous retrovirus activity.
Topics: Animals; Cell Dedifferentiation; Cell Lineage; Chimera; Chromatin; Embryo, Mammalian; Embryonic Stem Cells; Endogenous Retroviruses; Epigenesis, Genetic; Female; Gene Expression Regulation, Developmental; Genes, Reporter; Histones; Induced Pluripotent Stem Cells; Lysine; Methylation; Mice; Phenotype; Pluripotent Stem Cells; Terminal Repeat Sequences; Totipotent Stem Cells; Transcriptome | 2012 |
The cation-π interaction at protein-protein interaction interfaces: developing and learning from synthetic mimics of proteins that bind methylated lysines.
Topics: Arginine; Calixarenes; Cations; Humans; Hydrogen Bonding; Lysine; Methylation; Phenols; Protein Interaction Maps; Proteins | 2013 |
Histone H3 lysine 36 methylation targets the Isw1b remodeling complex to chromatin.
Topics: Adenosine Triphosphatases; Amino Acid Sequence; Chromatin; DNA-Binding Proteins; Genes, Fungal; Histones; Lysine; Methylation; Molecular Sequence Data; Protein Structure, Tertiary; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Transcriptional Activation | 2012 |
Histone H3 lysine 4 methylation marks postreplicative human cytomegalovirus chromatin.
Topics: Base Sequence; Cell Line; Chromatin; Cytomegalovirus; DNA Replication; DNA, Viral; Epigenesis, Genetic; Euchromatin; Genome, Viral; Heterochromatin; Histones; Humans; Lysine; Methylation; Virus Replication | 2012 |
Genome-wide bovine H3K27me3 modifications and the regulatory effects on genes expressions in peripheral blood lymphocytes.
Topics: Animals; Cattle; Chromatin Immunoprecipitation; DNA; Female; Gene Expression Regulation; Genome; Histones; Lactation; Lymphocytes; Lysine; Methylation; Oligonucleotide Array Sequence Analysis; Promoter Regions, Genetic; Real-Time Polymerase Chain Reaction; Sequence Analysis, DNA; Transcription Initiation Site; Transcription, Genetic | 2012 |
The association between H3K4me3 and antisense transcription.
Topics: Animals; Arabidopsis; Binding Sites; Cerebrum; Drosophila; Epigenesis, Genetic; Histones; Humans; Lysine; Male; Methylation; Mice; RNA Polymerase II; RNA, Antisense; Testis; Transcription Initiation Site; Transcription, Genetic; Transcriptional Activation | 2012 |
Nuclear dynamics of histone H3 trimethylated on lysine 9 and/or phosphorylated on serine 10 in mouse cloned embryos as new markers of reprogramming?
Topics: Animals; Antigens, Differentiation; Cell Dedifferentiation; Cloning, Organism; Embryo, Mammalian; Epigenesis, Genetic; Gene Expression Regulation, Developmental; Heterochromatin; Histones; Lysine; Methylation; Mice; Phosphorylation; Serine | 2012 |
IVMBIX-01294, an inhibitor of the histone methyltransferase EHMT2, disrupts histone H3 lysine 9 (H3K9) dimethylation in the cleavage-stage porcine embryo.
Topics: Animals; Azepines; Cleavage Stage, Ovum; Dose-Response Relationship, Drug; Embryo Culture Techniques; Embryo Transfer; Embryo, Mammalian; Embryonic Development; Enzyme Inhibitors; Female; Fertilization in Vitro; Gene Expression Regulation, Developmental; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Pregnancy; Pregnancy Rate; Quinazolines; RNA, Messenger; Swine; Time Factors; Transcription, Genetic | 2012 |
Prediction of protein methylation sites using conditional random field.
Topics: Arginine; Lysine; Markov Chains; Methylation; Protein Processing, Post-Translational; Proteins; ROC Curve; Sequence Analysis, Protein | 2013 |
A method to distinguish between lysine acetylation and lysine methylation from protein sequences.
Topics: Acetylation; Amino Acid Sequence; Amino Acids; Databases, Protein; Lysine; Methylation; Molecular Sequence Data; Position-Specific Scoring Matrices; Protein Structure, Secondary; Proteins; Sequence Analysis, Protein; Support Vector Machine | 2012 |
Quantitative modulation of polycomb silencing underlies natural variation in vernalization.
Topics: Arabidopsis; Arabidopsis Proteins; Chromatin; Chromatin Immunoprecipitation; Cold Temperature; DNA-Binding Proteins; Enhancer Elements, Genetic; Flowers; Gene Expression Regulation, Plant; Gene Silencing; Histones; Lysine; MADS Domain Proteins; Methylation; Polycomb Repressive Complex 2; Polycomb-Group Proteins; Polymorphism, Genetic; Repressor Proteins; Seasons | 2012 |
Identification of a novel function for the chromatin remodeling protein ING2 in muscle differentiation.
Topics: Amino Acid Motifs; Animals; Binding Sites; Cell Differentiation; Chromatin Assembly and Disassembly; Gene Knockdown Techniques; Histones; Homeodomain Proteins; Humans; Leucine Zippers; Lysine; Methylation; Mice; Muscle Cells; Muscle Development; Muscle, Skeletal; Myoblasts; Protein Binding; Protein Structure, Tertiary; Tumor Suppressor Proteins | 2012 |
Methylation of lysine 9 in histone H3 directs alternative modes of highly dynamic interaction of heterochromatin protein hHP1β with the nucleosome.
Topics: Biotinylation; Calorimetry; Chromatin; Chromobox Protein Homolog 5; Chromosomal Proteins, Non-Histone; DNA; Epigenesis, Genetic; Histones; Humans; Lysine; Magnetic Resonance Spectroscopy; Methylation; Nucleosomes; Protein Binding; Protein Structure, Tertiary; Schizosaccharomyces | 2012 |
Methylation of histone H3 at lysine 4 and expression of the maltase-glucoamylase gene are reduced by dietary resistant starch.
Topics: Acetylation; alpha-Glucosidases; Animals; Body Weight; Diet; Dietary Carbohydrates; Digestion; Gene Expression Regulation, Enzymologic; Genetic Loci; Histones; Jejunum; Lysine; Male; Methylation; Promoter Regions, Genetic; Rats; Rats, Wistar; RNA, Messenger; Starch; Transcription Factors | 2013 |
NEDDylation regulates E2F-1-dependent transcription.
Topics: Cell Line, Tumor; Cell Proliferation; E2F1 Transcription Factor; Humans; Lysine; Methylation; NEDD8 Protein; Protein Stability; Transcription, Genetic; Ubiquitination; Ubiquitins | 2012 |
A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response.
Topics: Amino Acid Sequence; Animals; Biocatalysis; Catalytic Domain; Cells, Cultured; Enzyme Inhibitors; Evolution, Molecular; Histones; Humans; Inhibitory Concentration 50; Jumonji Domain-Containing Histone Demethylases; Lysine; Macrophages; Methylation; Mice; Models, Molecular; Substrate Specificity; Tumor Necrosis Factor-alpha | 2012 |
Histone methylation analysis and pathway predictions in chickens after MDV infection.
Topics: Animals; Chickens; Chromatin Immunoprecipitation; Disease Resistance; Disease Susceptibility; Genomics; Histones; Lysine; Marek Disease; Methylation; MicroRNAs; Poultry Diseases; Sequence Analysis, DNA; Species Specificity; Spleen; Transcriptome | 2012 |
Carm1 regulates Pax7 transcriptional activity through MLL1/2 recruitment during asymmetric satellite stem cell divisions.
Topics: Amino Acid Motifs; Amino Acid Sequence; Animals; Arginine; Cell Division; DNA; HEK293 Cells; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Mice; Molecular Sequence Data; Myeloid-Lymphoid Leukemia Protein; Myogenic Regulatory Factor 5; PAX7 Transcription Factor; Promoter Regions, Genetic; Protein Binding; Protein Structure, Tertiary; Protein-Arginine N-Methyltransferases; Satellite Cells, Skeletal Muscle; Stem Cells; Substrate Specificity; Transcription, Genetic | 2012 |
PHF20 is an effector protein of p53 double lysine methylation that stabilizes and activates p53.
Topics: Antigens, Neoplasm; Biomarkers, Tumor; Cell Line; Cell Line, Tumor; Crystallography, X-Ray; DNA Damage; DNA-Binding Proteins; Gene Knockdown Techniques; Humans; Lysine; Methylation; Models, Molecular; Protein Multimerization; Protein Stability; Protein Structure, Tertiary; Transcription Factors; Tumor Suppressor Protein p53; Ubiquitination; Up-Regulation | 2012 |
Total kinetic analysis reveals how combinatorial methylation patterns are established on lysines 27 and 36 of histone H3.
Topics: Biochemistry; Cell Line; Combinatorial Chemistry Techniques; Epigenomics; Histone-Lysine N-Methyltransferase; Histones; Humans; Kinetics; Lysine; Mass Spectrometry; Methylation; Methyltransferases; Repressor Proteins | 2012 |
Rhythmic oscillation of histone acetylation and methylation at the Arabidopsis central clock loci.
Topics: Acetylation; Arabidopsis; Arabidopsis Proteins; Circadian Clocks; Circadian Rhythm; DNA-Binding Proteins; Gene Expression Regulation, Plant; Histones; Lysine; Methylation; Transcription Factors | 2012 |
Mechanisms of histone H3 lysine 27 trimethylation remodeling during early mammalian development.
Topics: Animals; Cattle; Cellular Reprogramming; Chromatin Assembly and Disassembly; Embryonic Development; Gene Expression Regulation, Developmental; Histones; Lysine; Methylation; Mice; Protein Processing, Post-Translational; Swine | 2012 |
A method to site-specifically incorporate methyl-lysine analogues into recombinant proteins.
Topics: Buffers; Dithiothreitol; Histones; Lysine; Methylation; Oxidation-Reduction; Recombinant Proteins; Reducing Agents; Staining and Labeling; Xenopus Proteins | 2012 |
Set2 methylation of histone H3 lysine 36 suppresses histone exchange on transcribed genes.
Topics: Acetylation; Cell Cycle Proteins; Genes, Fungal; Histones; Lysine; Methylation; Methyltransferases; Molecular Chaperones; Open Reading Frames; Phenotype; RNA Polymerase II; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Transcription, Genetic | 2012 |
Dense chromatin activates Polycomb repressive complex 2 to regulate H3 lysine 27 methylation.
Topics: Amino Acid Sequence; Animals; CD4-Positive T-Lymphocytes; Chromatin Immunoprecipitation; Cytochrome P-450 Enzyme System; Drosophila melanogaster; Drosophila Proteins; Embryonic Stem Cells; Gene Silencing; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Mice; Molecular Sequence Data; Mutagenesis; Nucleosomes; Peptide Fragments; Polycomb Repressive Complex 2; Polycomb-Group Proteins; Repressor Proteins; Retinoic Acid 4-Hydroxylase; Transcription, Genetic | 2012 |
Lysine methylation of VCP by a member of a novel human protein methyltransferase family.
Topics: Adenosine Triphosphatases; Amino Acid Motifs; Amino Acid Sequence; Cell Cycle Proteins; Cell Line; Humans; Lysine; Methylation; Methyltransferases; Molecular Sequence Data; Multigene Family; Sequence Alignment; Valosin Containing Protein | 2012 |
Mouse oocyte meiosis is disturbed by knockdown of Suv4-20h.
Topics: Animals; Centromere; Epigenesis, Genetic; Female; Gene Expression Regulation, Developmental; Heterochromatin; Histone-Lysine N-Methyltransferase; Histones; Isoenzymes; Lysine; Meiosis; Metaphase; Methylation; Mice; Oocytes; Oogenesis; Polar Bodies; Protein Processing, Post-Translational; RNA Interference; RNA, Messenger | 2013 |
Histone H3 lysine 4 monomethylation (H3K4me1) and H3 lysine 9 monomethylation (H3K9me1): distribution and their association in regulating gene expression under hyperglycaemic/hyperinsulinemic conditions in 3T3 cells.
Topics: 3T3 Cells; Acetylation; Animals; Chromatin Assembly and Disassembly; Chromatin Immunoprecipitation; Cluster Analysis; Gene Expression; Gene Expression Profiling; Histone Acetyltransferases; Histone Deacetylases; Histone Demethylases; Histones; Hyperglycemia; Hyperinsulinism; Hypoglycemic Agents; Insulin; Jumonji Domain-Containing Histone Demethylases; Lysine; Methylation; Mice; Oligonucleotide Array Sequence Analysis; Oxidoreductases, N-Demethylating | 2012 |
Chromatin structure of ribosomal RNA genes in dipterans and its relationship to the location of nucleolar organizers.
Topics: Animals; Chironomidae; Chromatin; Diptera; DNA, Ribosomal; Drosophila melanogaster; Electrophoretic Mobility Shift Assay; Histones; Lysine; Methylation; Nucleolus Organizer Region; Repetitive Sequences, Nucleic Acid; RNA, Ribosomal | 2012 |
Study of methylation of histone H3 lysine 9 and H3 lysine 27 during X chromosome inactivation in three types of cells.
Topics: Cell Line; Chromatin Immunoprecipitation; DNA Primers; Fluorescent Antibody Technique, Indirect; HeLa Cells; Histones; Humans; Lysine; Methylation; Polymerase Chain Reaction; X Chromosome Inactivation | 2012 |
The cellular level of histone H3 lysine 4 dimethylation correlates with response to adjuvant gemcitabine in Japanese pancreatic cancer patients treated with surgery.
Topics: Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplastic; Chemotherapy, Adjuvant; Deoxycytidine; Disease-Free Survival; Female; Gemcitabine; Histones; Humans; Immunohistochemistry; Lysine; Male; Methylation; Middle Aged; Pancreatic Neoplasms | 2012 |
Lysine methylation strategies for characterizing protein conformations by NMR.
Topics: Carbon Isotopes; Hydrogen-Ion Concentration; Kinetics; Lysine; Methylation; Nuclear Magnetic Resonance, Biomolecular; Protein Conformation; Proteins | 2012 |
Argonaute proteins couple chromatin silencing to alternative splicing.
Topics: Alternative Splicing; Animals; Argonaute Proteins; Chromatin; Chromosomal Proteins, Non-Histone; DEAD-box RNA Helicases; Eukaryotic Initiation Factors; Fibroblasts; HeLa Cells; Histones; Humans; Hyaluronan Receptors; Lysine; Methylation; Mice; Ribonuclease III; RNA Precursors; RNA, Small Interfering; Spliceosomes | 2012 |
Epigenetic regulation of cell adhesion and communication by enhancer of zeste homolog 2 in human endothelial cells.
Topics: Cell Adhesion; Cell Communication; Cell Movement; Cells, Cultured; Chromatin Immunoprecipitation; Enhancer of Zeste Homolog 2 Protein; Epigenomics; Gene Expression Profiling; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Human Umbilical Vein Endothelial Cells; Humans; Lysine; Methylation; Neovascularization, Physiologic; Oligonucleotide Array Sequence Analysis; Polycomb Repressive Complex 2; RNA Interference | 2012 |
Epigenetic modifications and mRNA levels of the imprinted gene Grb10 in serially passaged fibroblast cells.
Topics: 5-Methylcytosine; Acetylation; Animals; Cell Proliferation; Chromatin Immunoprecipitation; CpG Islands; DNA Methylation; Epigenesis, Genetic; Fibroblasts; Gene Expression; Genomic Imprinting; GRB10 Adaptor Protein; Histones; Immunohistochemistry; Lysine; Methylation; Mice; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sequence Analysis, DNA; Time Factors | 2012 |
LC2 and OsVIL2 promote rice flowering by photoperoid-induced epigenetic silencing of OsLF.
Topics: Flowers; Gene Silencing; Histones; Light; Lysine; Methylation; Oryza; Photoperiod; Plant Proteins; Promoter Regions, Genetic; Repressor Proteins | 2013 |
Induction of aberrant trimethylation of histone H3 lysine 27 by inflammation in mouse colonic epithelial cells.
Topics: Aging; Animals; Apoptosis Regulatory Proteins; Calcium-Calmodulin-Dependent Protein Kinases; Colitis; Colon; Death-Associated Protein Kinases; Dextran Sulfate; Epithelial Cells; Gene Expression; Histones; Intestinal Mucosa; Lysine; Male; Methylation; Mice; Mice, Inbred BALB C; Neoplasms | 2012 |
A transcription factor-based mechanism for mouse heterochromatin formation.
Topics: Animals; Base Sequence; Binding Sites; Cell Cycle; Chromosome Segregation; DNA, Satellite; Fibroblasts; Genome; Heterochromatin; Histones; Lysine; Methylation; Methyltransferases; Mice; Mice, Mutant Strains; Molecular Sequence Data; Paired Box Transcription Factors; PAX3 Transcription Factor; PAX5 Transcription Factor; PAX7 Transcription Factor; PAX9 Transcription Factor; Repressor Proteins | 2012 |
Enhanced HSP70 lysine methylation promotes proliferation of cancer cells through activation of Aurora kinase B.
Topics: Animals; Aurora Kinase B; Aurora Kinases; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Chlorocebus aethiops; COS Cells; HSP70 Heat-Shock Proteins; Humans; Immunohistochemistry; Immunoprecipitation; Lysine; Methylation; Protein Binding; Protein Serine-Threonine Kinases; Tissue Array Analysis | 2012 |
Cell signaling, post-translational protein modifications and NMR spectroscopy.
Topics: Acetylation; Acylation; Alkylation; Amino Acids; Arginine; Cell Communication; Eukaryotic Cells; Glycosylation; Histidine; Lysine; Magnetic Resonance Spectroscopy; Methylation; Phosphorylation; Protein Processing, Post-Translational; Proteins; Serine; Threonine; Tyrosine | 2012 |
Small-molecule histone methyltransferase inhibitors display rapid antimalarial activity against all blood stage forms in Plasmodium falciparum.
Topics: Amino Acid Sequence; Animals; Antimalarials; Azepines; Blotting, Western; Cells, Cultured; Dose-Response Relationship, Drug; Erythrocytes; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; Life Cycle Stages; Lysine; Malaria; Methylation; Mice; Mice, Inbred C57BL; Molecular Sequence Data; Parasitemia; Plasmodium berghei; Plasmodium falciparum; Quinazolines; Sequence Homology, Amino Acid | 2012 |
H3K9 trimethylation precedes DNA methylation during sheep oogenesis: HDAC1, SUV39H1, G9a, HP1, and Dnmts are involved in these epigenetic events.
Topics: Animals; Chromobox Protein Homolog 5; Chromosomal Proteins, Non-Histone; Computer Simulation; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Methyltransferase 3A; Epigenesis, Genetic; Histone Deacetylase 1; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Immunohistochemistry; Lysine; Methylation; Oogenesis; Sheep | 2013 |
A selective inhibitor of EZH2 blocks H3K27 methylation and kills mutant lymphoma cells.
Topics: Antineoplastic Agents; Cell Cycle; Cell Death; Cell Proliferation; Dose-Response Relationship, Drug; Enhancer of Zeste Homolog 2 Protein; Enzyme Inhibitors; Histones; Humans; Indazoles; Lymphoma; Lysine; Methylation; Molecular Structure; Point Mutation; Polycomb Repressive Complex 2; Pyridones; Structure-Activity Relationship | 2012 |
Acute stress and hippocampal histone H3 lysine 9 trimethylation, a retrotransposon silencing response.
Topics: Animals; Chromatin Immunoprecipitation; Corticosterone; DNA; Gene Silencing; Hippocampus; Histones; Lysine; Male; Methylation; Rats; Rats, Sprague-Dawley; Receptors, Glucocorticoid; Retroelements; Stress, Physiological | 2012 |
Neonatal isolation decreases cued fear conditioning and frontal cortical histone 3 lysine 9 methylation in adult female rats.
Topics: Acoustic Stimulation; Age Factors; Animals; Animals, Newborn; Azacitidine; Behavior, Animal; Cerebral Cortex; Conditioning, Psychological; Corticosterone; Cues; Decitabine; DNA Modification Methylases; Dose-Response Relationship, Drug; Down-Regulation; Estradiol; Fear; Female; Histone Deacetylase Inhibitors; Histones; Light; Lysine; Maternal Deprivation; Methylation; Photic Stimulation; Rats; Rats, Sprague-Dawley; Reflex, Startle; Stress, Psychological; Valproic Acid | 2012 |
Stage and gene specific signatures defined by histones H3K4me2 and H3K27me3 accompany mammalian retina maturation in vivo.
Topics: Animals; Cell Lineage; Chromatin Immunoprecipitation; Epigenesis, Genetic; Genomics; Histones; Lysine; Methylation; Mice; Organogenesis; Retina; Retinal Rod Photoreceptor Cells; Transcriptome | 2012 |
New partners in regulation of gene expression: the enhancer of Trithorax and Polycomb Corto interacts with methylated ribosomal protein l12 via its chromodomain.
Topics: Amino Acid Sequence; Animals; Animals, Genetically Modified; Chromatin; Chromosomal Proteins, Non-Histone; DNA-Binding Proteins; Drosophila melanogaster; Drosophila Proteins; Gene Expression; Gene Expression Profiling; Gene Expression Regulation; Genome-Wide Association Study; HSP70 Heat-Shock Proteins; Lysine; Methylation; Molecular Sequence Data; Phenotype; Polycomb Repressive Complex 1; Polytene Chromosomes; Protein Binding; Protein Interaction Domains and Motifs; Ribosomal Proteins; Sequence Alignment; Transcription, Genetic; Transcriptome | 2012 |
Loss of LSD1 (lysine-specific demethylase 1) suppresses growth and alters gene expression of human colon cancer cells in a p53- and DNMT1(DNA methyltransferase 1)-independent manner.
Topics: Animals; Blotting, Western; Cell Proliferation; Cluster Analysis; Colonic Neoplasms; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Gene Knockout Techniques; HCT116 Cells; Histone Demethylases; Histones; Humans; Lysine; Methylation; Mice; Mice, Nude; Neoplasms, Experimental; Oligonucleotide Array Sequence Analysis; Transplantation, Heterologous; Tumor Suppressor Protein p53 | 2013 |
Distinct mode of methylated lysine-4 of histone H3 recognition by tandem tudor-like domains of Spindlin1.
Topics: Amino Acid Sequence; Cell Cycle Proteins; Crystallography, X-Ray; Histones; Lysine; Methylation; Microtubule-Associated Proteins; Models, Molecular; Molecular Sequence Data; Phosphoproteins; Sequence Homology, Amino Acid | 2012 |
G9a mediates Sharp-1-dependent inhibition of skeletal muscle differentiation.
Topics: Animals; Blotting, Western; Cell Differentiation; Cell Line; Gene Expression Regulation; HEK293 Cells; Histone-Lysine N-Methyltransferase; Histones; Humans; Luciferases; Lysine; Methylation; Mice; Microscopy, Fluorescence; Muscle, Skeletal; Mutation; Myoblasts; MyoD Protein; Myogenin; NIH 3T3 Cells; Promoter Regions, Genetic; Protein Binding; RNA Interference; Transcription Factors | 2012 |
Histone H3K4 demethylation is negatively regulated by histone H3 acetylation in Saccharomyces cerevisiae.
Topics: Acetylation; Gene Expression Regulation, Fungal; Histone Acetyltransferases; Histones; Jumonji Domain-Containing Histone Demethylases; Lysine; Methylation; Models, Biological; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Substrate Specificity | 2012 |
Coordinated repression of cell cycle genes by KDM5A and E2F4 during differentiation.
Topics: Animals; Cell Differentiation; Chromatin Immunoprecipitation; E2F4 Transcription Factor; Embryonic Stem Cells; Genes, cdc; Histones; Humans; Lysine; Methylation; Mice; Mice, Inbred C57BL; Multiprotein Complexes; Protein Binding; Repressor Proteins; Retinoblastoma-Binding Protein 2; U937 Cells | 2012 |
Lamin B receptor recognizes specific modifications of histone H4 in heterochromatin formation.
Topics: Amino Acid Sequence; HEK293 Cells; HeLa Cells; Heterochromatin; Histones; Humans; Lamin B Receptor; Lamin Type B; Lysine; Methylation; Models, Biological; Molecular Sequence Data; Nuclear Envelope; Protein Binding; Protein Multimerization; Protein Processing, Post-Translational; Protein Structure, Tertiary; Receptors, Cytoplasmic and Nuclear; Repressor Proteins; Transcription, Genetic | 2012 |
Hinge and chromoshadow of HP1α participate in recognition of K9 methylated histone H3 in nucleosomes.
Topics: Amino Acid Sequence; Chromobox Protein Homolog 5; Chromosomal Proteins, Non-Histone; Electrophoretic Mobility Shift Assay; Escherichia coli; Heterochromatin; Histones; Humans; Lysine; Methylation; Models, Molecular; Neurospora crassa; Nucleosomes; Protein Binding; Protein Structure, Tertiary; Recombinant Fusion Proteins; Sequence Deletion; Substrate Specificity | 2013 |
Identification and characterization of an epi-allele of FIE1 reveals a regulatory linkage between two epigenetic marks in rice.
Topics: Alleles; DNA Methylation; Epigenetic Repression; Flowers; Gene Expression; Gene Expression Regulation, Plant; Genes, Dominant; Genomic Imprinting; Heterochromatin; Histones; Lysine; Methylation; Mutation; Oryza; Phenotype; Plant Proteins; Polycomb Repressive Complex 2; Seedlings; Two-Hybrid System Techniques | 2012 |
The COMPASS subunit Spp1 links histone methylation to initiation of meiotic recombination.
Topics: Chromatin; Chromosomes, Fungal; DNA Breaks, Double-Stranded; DNA-Binding Proteins; Endodeoxyribonucleases; Histones; Lysine; Meiosis; Methylation; Protein Subunits; Recombination, Genetic; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins | 2013 |
Structural insight into coordinated recognition of trimethylated histone H3 lysine 9 (H3K9me3) by the plant homeodomain (PHD) and tandem tudor domain (TTD) of UHRF1 (ubiquitin-like, containing PHD and RING finger domains, 1) protein.
Topics: Binding Sites; CCAAT-Enhancer-Binding Proteins; Crystallization; Fluorescence Resonance Energy Transfer; Histones; Humans; Lysine; Methylation; Protein Conformation; RING Finger Domains; Ubiquitin-Protein Ligases; Ubiquitination | 2013 |
Histone H3K9 methyltransferase G9a represses PPARγ expression and adipogenesis.
Topics: 3T3-L1 Cells; Adipocytes, Brown; Adipogenesis; Animals; CCAAT-Enhancer-Binding Protein-beta; Cell Differentiation; Chromatin; Chromatin Immunoprecipitation; Epigenesis, Genetic; Female; Histone Demethylases; Histone-Lysine N-Methyltransferase; Histones; Lysine; Male; Methylation; Mice; Mice, Knockout; Nerve Tissue Proteins; PPAR gamma; Promoter Regions, Genetic; Sequence Analysis, DNA; Sequence Deletion; Wnt Proteins | 2013 |
Aberrant patterns of H3K4 and H3K27 histone lysine methylation occur across subgroups in medulloblastoma.
Topics: Base Sequence; Cerebellar Neoplasms; Cohort Studies; DNA-Binding Proteins; Female; Genetic Predisposition to Disease; Genome; Histone Demethylases; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Humans; Lysine; Male; Medulloblastoma; Methylation; Mutation; Neoplasm Proteins; Nuclear Proteins; Polymorphism, Single Nucleotide | 2013 |
Epigenetic regulation of CXCR4 expression by the ocular microenvironment.
Topics: Animals; Anterior Chamber; Antimetabolites, Antineoplastic; Azacitidine; Cecum; Cell Line, Tumor; Decitabine; Down-Regulation; Epigenesis, Genetic; Flow Cytometry; Gene Expression; Gene Expression Regulation, Neoplastic; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Hydroxamic Acids; Injections; Injections, Subcutaneous; Lysine; Methylation; Mice; Mice, Inbred BALB C; Neoplasm Transplantation; Promoter Regions, Genetic; Receptors, CXCR4; Reverse Transcriptase Polymerase Chain Reaction; Spleen; Up-Regulation | 2013 |
The histone H3K27 methylation mark regulates intestinal epithelial cell density-dependent proliferation and the inflammatory response.
Topics: Animals; beta Catenin; Cell Count; Cell Differentiation; Cell Line; Cell Proliferation; Enhancer of Zeste Homolog 2 Protein; Epithelial Cells; Gene Expression Regulation; Histones; Inflammation; Interleukin-1beta; Intestinal Mucosa; Intestines; Lysine; Methylation; Mice; Microvilli; Neurons; Polycomb Repressive Complex 2; Rats; Signal Transduction; STAT3 Transcription Factor | 2013 |
Gene regulation by the lysine demethylase KDM4A in Drosophila.
Topics: Alleles; Animals; Chromobox Protein Homolog 5; Chromosomal Proteins, Non-Histone; Drosophila melanogaster; Drosophila Proteins; Gene Expression Regulation, Developmental; Histone Demethylases; Histones; Lysine; Male; Methylation | 2013 |
Selective molecular recognition of methylated lysines and arginines by cucurbit[6]uril and cucurbit[7]uril in aqueous solution.
Topics: Arginine; Bridged-Ring Compounds; Imidazoles; Lysine; Methylation; Molecular Structure; Solutions; Water | 2013 |
Impact of histone H4 lysine 20 methylation on 53BP1 responses to chromosomal double strand breaks.
Topics: Animals; Cell Line; Chromatin; Chromosomal Proteins, Non-Histone; DNA Breaks, Double-Stranded; DNA Repair; DNA-Binding Proteins; Histone-Lysine N-Methyltransferase; Histones; Humans; Kinetics; Lasers; Lysine; Methylation; Mice; Protein Transport; Tumor Suppressor p53-Binding Protein 1; Ubiquitin-Protein Ligases | 2012 |
Utilization of lysine ¹³C-methylation NMR for protein-protein interaction studies.
Topics: Carbon Isotopes; Endopeptidases; Humans; Lysine; Methylation; Molecular Docking Simulation; Nuclear Magnetic Resonance, Biomolecular; Protein Binding; Protein Conformation; Protein Interaction Mapping; Proteins; Ubiquitin | 2013 |
Ordered changes in histone modifications at the core of the Arabidopsis circadian clock.
Topics: Arabidopsis; Arabidopsis Proteins; Circadian Clocks; Gene Expression Regulation, Plant; Genes, Plant; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Protein Binding; Protein Processing, Post-Translational; Repressor Proteins | 2012 |
H3K36 methylation is involved in promoting rice flowering.
Topics: Flowers; Gene Expression Regulation, Plant; Gene Knockdown Techniques; Histones; Lysine; Methylation; Mutation; Oryza; Phenotype; Plant Proteins | 2013 |
G9a co-localized with histone H3 lysine 9 monomethylation but not dimethylation in a nuclear membrane-dependent manner during mouse preimplantation embryo development.
Topics: Animals; Blastocyst; Embryonic Development; Female; Gene Expression Regulation, Developmental; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Mice; Nuclear Envelope; Nuclear Localization Signals; Pregnancy | 2013 |
Natural variation of H3K27me3 distribution between two Arabidopsis accessions and its association with flanking transposable elements.
Topics: Arabidopsis; Chromatin; DNA Transposable Elements; Epigenesis, Genetic; Gene Expression; Gene Expression Regulation, Plant; Genes, Plant; Genetic Variation; Genome, Plant; Histones; Lysine; Methylation | 2012 |
LSD2/KDM1B and its cofactor NPAC/GLYR1 endow a structural and molecular model for regulation of H3K4 demethylation.
Topics: Alcohol Oxidoreductases; Amino Acid Sequence; Coenzymes; Crystallography, X-Ray; Enzyme Stability; HeLa Cells; Histones; Humans; Lysine; Methylation; Models, Molecular; Molecular Sequence Data; Oxidoreductases, N-Demethylating; Peptides; Protein Binding; Substrate Specificity | 2013 |
The conserved PHD1-PHD2 domain of ZFP-1/AF10 is a discrete functional module essential for viability in Caenorhabditis elegans.
Topics: Amino Acid Sequence; Animals; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Chromatin; Gene Expression Regulation, Developmental; Histones; Lysine; Methylation; Molecular Sequence Data; Promoter Regions, Genetic; Protein Isoforms; Protein Multimerization; RNA Interference; Sequence Alignment; Transcription Factors; Zinc Fingers | 2013 |
An H3K36 methylation-engaging Tudor motif of polycomb-like proteins mediates PRC2 complex targeting.
Topics: Amino Acid Motifs; Animals; Calorimetry; Carrier Proteins; Cell Differentiation; Cell Nucleus; Conserved Sequence; DNA-Binding Proteins; Genetic Complementation Test; Genetic Loci; Histones; Humans; Lysine; Methylation; Mice; Models, Molecular; Nuclear Proteins; Peptides; Pluripotent Stem Cells; Polycomb Repressive Complex 2; Polycomb-Group Proteins; Protein Binding; Protein Transport; Structure-Activity Relationship; Thermodynamics; Transcription Factors | 2013 |
Prediction of methylation sites using the composition of K-spaced amino acid pairs.
Topics: Amino Acids; Arginine; Computational Biology; Lysine; Methylation; Protein Processing, Post-Translational; Proteins; Sensitivity and Specificity; Support Vector Machine | 2013 |
Examining post-translational modification-mediated protein-protein interactions using a chemical proteomics approach.
Topics: Biomarkers; Cell Division; Chromobox Protein Homolog 5; Chromosomal Proteins, Non-Histone; HeLa Cells; Histones; Humans; Inhibitor of Apoptosis Proteins; Kinesins; Lysine; Methylation; Molecular Probe Techniques; Peptide Fragments; Phosphorylation; Protein Interaction Domains and Motifs; Protein Processing, Post-Translational; Proteomics; Recombinant Proteins; Survivin; Threonine; Yeasts | 2013 |
Transcriptional regulation of 15-lipoxygenase expression by histone h3 lysine 4 methylation/demethylation.
Topics: Arachidonate 15-Lipoxygenase; Cell Line; Chromatin Assembly and Disassembly; Gene Expression Regulation; Histone Demethylases; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Models, Biological; Oxidoreductases, N-Demethylating; Promoter Regions, Genetic; Protein Binding; STAT6 Transcription Factor; Transcription, Genetic; Transcriptional Activation | 2012 |
Crystal structure of the human SUV39H1 chromodomain and its recognition of histone H3K9me2/3.
Topics: Amino Acid Sequence; Crystallization; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Methyltransferases; Models, Molecular; Molecular Sequence Data; Protein Binding; Protein Interaction Domains and Motifs; Protein Interaction Maps; Protein Structure, Secondary; Repressor Proteins; Sequence Homology, Amino Acid | 2012 |
Decoupling epigenetic and genetic effects through systematic analysis of gene position.
Topics: Acetylation; Chromatin; Chromosomal Position Effects; Chromosomes, Fungal; Diploidy; Epigenesis, Genetic; Gene Deletion; Gene Expression Regulation, Fungal; Gene Knockout Techniques; Gene Library; Gene Order; Genes, Fungal; Genetic Markers; Heterozygote; Histones; Lysine; Methylation; Mutagenesis, Insertional; Promoter Regions, Genetic; Protein Binding; Protein Processing, Post-Translational; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Signal Transduction | 2013 |
[Investigation of histone H3 methylation during long term memory formation].
Topics: Animals; Appetitive Behavior; Blotting, Western; Central Nervous System; Chromatin Assembly and Disassembly; Epigenesis, Genetic; Helix, Snails; Histones; Lysine; Memory, Long-Term; Methylation; Protein Processing, Post-Translational; Transcription, Genetic | 2012 |
Lysyl 5-hydroxylation, a novel histone modification, by Jumonji domain containing 6 (JMJD6).
Topics: Acetylation; Animals; Chromosomes, Mammalian; HEK293 Cells; Histones; Humans; Hydroxylation; Jumonji Domain-Containing Histone Demethylases; Lysine; Male; Methylation; Mice; Mice, Knockout; Organ Specificity; Protein Processing, Post-Translational; Testis; Transcription, Genetic | 2013 |
Alteration of histone H3 lysine 4 trimethylation on putative lytic gene promoters by human Set1 complex during reactivation of Kaposi's sarcoma-associated herpesvirus.
Topics: Cell Line; Gene Expression Regulation, Viral; Herpesvirus 8, Human; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Promoter Regions, Genetic; Up-Regulation; Viral Proteins; Virus Activation; Virus Latency | 2013 |
Detection of histone modifications at specific gene loci in single cells in histological sections.
Topics: Animals; Atherosclerosis; Cell Lineage; Chromatin Immunoprecipitation; Epigenesis, Genetic; Fixatives; Formaldehyde; Histones; Humans; In Situ Hybridization; Lysine; Male; Methylation; Mice; Myocytes, Smooth Muscle; Myosin Heavy Chains; Paraffin Embedding | 2013 |
Chd5 requires PHD-mediated histone 3 binding for tumor suppression.
Topics: Amino Acid Sequence; Animals; Cell Differentiation; Cell Proliferation; Cell Transformation, Neoplastic; DNA Helicases; Genetic Loci; Genome; Histones; Homeodomain Proteins; Humans; Lysine; Methylation; Mice; Models, Molecular; Molecular Sequence Data; Mutation; Neoplasms; Neuroblastoma; Peptides; Protein Binding; Structure-Activity Relationship | 2013 |
The proteomic investigation of chromatin functional domains reveals novel synergisms among distinct heterochromatin components.
Topics: Adenosine Triphosphatases; Animals; Blotting, Western; Chromatin; Chromatin Immunoprecipitation; DNA Damage; HeLa Cells; Heterochromatin; Histones; Humans; Isotope Labeling; Lysine; Methylation; Mice; NIH 3T3 Cells; Phosphorylation; Protein Processing, Post-Translational; Proteome; Proteomics; Tandem Mass Spectrometry; Transcription Factors; Tyrosine | 2013 |
Aqp5 is a new transcriptional target of Dot1a and a regulator of Aqp2.
Topics: Amino Acid Sequence; Animals; Aquaporin 2; Aquaporin 5; Base Sequence; Cell Nucleus; Chromatin Immunoprecipitation; Diabetic Nephropathies; Endoplasmic Reticulum; Golgi Apparatus; Histone-Lysine N-Methyltransferase; Histones; Humans; Kidney; Lysine; Methylation; Methyltransferases; Mice; Molecular Sequence Data; Oligonucleotide Array Sequence Analysis; Polyuria; Protein Binding; Protein Transport; Regulatory Sequences, Nucleic Acid; RNA, Messenger; Transcription, Genetic; Up-Regulation | 2013 |
Induction of the BCMO1 gene during the suckling-weaning transition in rats is associated with histone H3 K4 methylation and subsequent coactivator binding and histone H3 acetylation to the gene.
Topics: Acetylation; Animals; Animals, Suckling; beta-Carotene 15,15'-Monooxygenase; Chromatin Immunoprecipitation; Gene Expression Regulation; Histones; Jejunum; Lysine; Methylation; Promoter Regions, Genetic; Rats; Rats, Sprague-Dawley; RNA, Messenger; Thyroid Hormone Receptors alpha; Transcription Factors; Weaning | 2012 |
Histone modification mapping in human brain reveals aberrant expression of histone H3 lysine 79 dimethylation in neural tube defects.
Topics: Animals; Blotting, Western; Chromatin Immunoprecipitation; Female; Fetus; Histones; Humans; Lysine; Male; Methylation; Mice; Neural Tube Defects; Protein Processing, Post-Translational; Tandem Mass Spectrometry | 2013 |
Dot1-dependent histone H3K79 methylation promotes activation of the Mek1 meiotic checkpoint effector kinase by regulating the Hop1 adaptor.
Topics: Chromatin Assembly and Disassembly; DNA Breaks, Double-Stranded; DNA-Binding Proteins; Gene Expression Regulation; Histone-Lysine N-Methyltransferase; Histones; Lysine; MAP Kinase Kinase 1; Meiosis; Methylation; Mutation; Nuclear Proteins; Recombination, Genetic; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins | 2013 |
Role of STAT3 and vitamin D receptor in EZH2-mediated invasion of human colorectal cancer.
Topics: Animals; Base Sequence; Cell Line, Tumor; Colorectal Neoplasms; Down-Regulation; Enhancer of Zeste Homolog 2 Protein; Gene Expression Regulation, Neoplastic; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Matrix Metalloproteinase 2; Matrix Metalloproteinase 9; Methylation; Mice; Mice, Inbred BALB C; Mice, Nude; Molecular Sequence Data; Neoplasm Invasiveness; Polycomb Repressive Complex 2; Receptors, Calcitriol; Recombinant Fusion Proteins; RNA Interference; Signal Transduction; STAT3 Transcription Factor | 2013 |
H3K56me3 is a novel, conserved heterochromatic mark that largely but not completely overlaps with H3K9me3 in both regulation and localization.
Topics: Animals; Cell Cycle; Cell Line; Chromatin; DNA Methylation; HeLa Cells; Heterochromatin; Histones; Humans; Lysine; Methylation; Mice; Microscopy, Fluorescence; Polymerase Chain Reaction | 2013 |
H3K4me3 interactions with TAF3 regulate preinitiation complex assembly and selective gene activation.
Topics: Cell Line, Tumor; Histone Code; Histones; Humans; Lysine; Methylation; p300-CBP Transcription Factors; TATA Box; TATA-Binding Protein Associated Factors; Transcription Factor TFIID; Transcription Initiation, Genetic; Transcriptional Activation; Tumor Suppressor Protein p53 | 2013 |
Protein-coding cis-natural antisense transcripts have high and broad expression in Arabidopsis.
Topics: Acetylation; Arabidopsis; Chromosomes, Plant; Gene Expression Regulation, Plant; Gene Silencing; Genes, Plant; Histones; Lysine; Methylation; Mutation; Open Reading Frames; RNA, Antisense; RNA, Plant; Transcription, Genetic | 2013 |
Quantitative analysis of histone modifications: formaldehyde is a source of pathological n(6)-formyllysine that is refractory to histone deacetylases.
Topics: Acetylation; Formaldehyde; Gene Expression; Histone Deacetylases; Histones; Humans; Lysine; Methylation; Protein Processing, Post-Translational; Respiratory Hypersensitivity | 2013 |
Assembling a COMPASS.
Topics: Animals; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Microscopy, Electron; Multienzyme Complexes; Protein Conformation; Protein Multimerization; Protein Subunits; Saccharomyces cerevisiae Proteins | 2013 |
SDG2-mediated H3K4 methylation is required for proper Arabidopsis root growth and development.
Topics: Arabidopsis; Arabidopsis Proteins; Chromatin Assembly and Disassembly; Chromatin Assembly Factor-1; Comet Assay; DNA Damage; Fluorescent Antibody Technique; Genomic Instability; Histones; Indoleacetic Acids; Lysine; Methylation; Methyltransferases; Microscopy, Confocal; Plant Roots | 2013 |
Global histone modification of H3K27 correlates with the outcomes in patients with metachronous liver metastasis of colorectal cancer.
Topics: Adenocarcinoma; Adult; Aged; Colorectal Neoplasms; DNA Methylation; Enhancer of Zeste Homolog 2 Protein; Female; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Histones; Humans; Immunohistochemistry; Kaplan-Meier Estimate; Liver Neoplasms; Lysine; Male; Methylation; Middle Aged; Multivariate Analysis; Neoplasms, Second Primary; Polycomb Repressive Complex 2; Prognosis; Retrospective Studies; Risk Factors; Tissue Array Analysis | 2013 |
Regional control of histone H3 lysine 27 methylation in Neurospora.
Topics: Catalytic Domain; Cluster Analysis; Computational Biology; Epigenesis, Genetic; Gene Deletion; Gene Expression Regulation, Fungal; Genome, Fungal; Histones; Lysine; Markov Chains; Methylation; Neurospora; Sequence Analysis, DNA | 2013 |
Inhibition of PRC2 activity by a gain-of-function H3 mutation found in pediatric glioblastoma.
Topics: Amino Acid Substitution; Animals; Brain Neoplasms; Child; Enhancer of Zeste Homolog 2 Protein; Epigenesis, Genetic; Glioblastoma; HEK293 Cells; Histones; Humans; Lysine; Methionine; Methylation; Mice; Mutation, Missense; Polycomb Repressive Complex 2; Transgenes | 2013 |
Cancer-associated upregulation of histone H3 lysine 9 trimethylation promotes cell motility in vitro and drives tumor formation in vivo.
Topics: Aged; Aged, 80 and over; Animals; Breast Neoplasms; Carcinogenesis; Cell Line, Tumor; Cell Movement; Colorectal Neoplasms; Epigenesis, Genetic; Female; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; Lymph Nodes; Lymphatic Metastasis; Lysine; Male; Methylation; Methyltransferases; Mice; Mice, Inbred BALB C; Mice, Nude; Middle Aged; Neoplasm Invasiveness; Repressor Proteins; Up-Regulation | 2013 |
Menin mediates epigenetic regulation via histone H3 lysine 9 methylation.
Topics: Animals; Cell Transformation, Neoplastic; Chromatin Assembly and Disassembly; Epigenesis, Genetic; Fibroblasts; HEK293 Cells; Histones; Homeodomain Proteins; Humans; Lysine; Methylation; Methyltransferases; Mice; Mutation; Protein Transport; Proto-Oncogene Proteins; Repressor Proteins; Signal Transduction | 2013 |
A general molecular affinity strategy for global detection and proteomic analysis of lysine methylation.
Topics: Animals; Cell Line; HEK293 Cells; Humans; Insecta; Lysine; Methylation; Protein Structure, Tertiary; Proteome; Proteomics; Sf9 Cells; Sirtuin 1 | 2013 |
Integration of genome-wide approaches identifies lncRNAs of adult neural stem cells and their progeny in vivo.
Topics: Adult Stem Cells; Alternative Splicing; Animals; Cell Differentiation; Cell Lineage; Cerebral Ventricles; Embryonic Stem Cells; Gene Expression Regulation, Developmental; Genome; Histones; Humans; Lysine; Male; Methylation; Mice; Mice, Inbred C57BL; Neural Stem Cells; Neurogenesis; Neurons; Protein Isoforms; Protein Processing, Post-Translational; Reproducibility of Results; RNA, Long Noncoding; RNA, Messenger; Time Factors | 2013 |
Single-molecule analysis of combinatorial epigenomic states in normal and tumor cells.
Topics: Animals; Cell Line; Cell Line, Tumor; Chromatin; Cytosine; Epigenesis, Genetic; Epigenomics; Fibroblasts; Gene Expression Regulation, Neoplastic; Gene Silencing; Histones; Humans; Lysine; Methylation; Mice; Protein Binding | 2013 |
Max is a repressor of germ cell-related gene expression in mouse embryonic stem cells.
Topics: Animals; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Biomarkers; Cell Line; DEAD-box RNA Helicases; Embryonic Stem Cells; Flow Cytometry; Gene Expression Regulation, Developmental; Gene Knockdown Techniques; Genes, Reporter; Germ Cells; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Lysine; Meiosis; Methylation; Mice; Mice, Inbred C57BL; Oligonucleotide Array Sequence Analysis; Promoter Regions, Genetic; Protein Binding; Repressor Proteins; RNA Interference; Spermatogenesis; Time Factors; Up-Regulation | 2013 |
BRCA1 is a negative modulator of the PRC2 complex.
Topics: Animals; BRCA1 Protein; Cell Differentiation; Cell Line, Tumor; Cell Movement; Embryonic Stem Cells; Enhancer of Zeste Homolog 2 Protein; Female; Gene Expression Regulation, Neoplastic; Histones; Humans; Lysine; Methylation; Mice; Polycomb Repressive Complex 2; Protein Binding; RNA, Untranslated | 2013 |
The dynamics of histone H3 modifications is species-specific in plant meiosis.
Topics: Acetylation; Arabidopsis; Chromosomes, Plant; Heterochromatin; Histones; Lysine; Meiosis; Methylation; Mitosis; Phosphorylation; Plants; Poaceae; Secale; Serine; Species Specificity | 2013 |
EMBRYONIC FLOWER1 and ULTRAPETALA1 Act Antagonistically on Arabidopsis Development and Stress Response.
Topics: Arabidopsis; Arabidopsis Proteins; Epigenesis, Genetic; Flowers; Gene Expression Regulation, Plant; Histones; Lysine; Methylation; Mutation; Phenotype; Plant Leaves; Plants, Genetically Modified; Seeds; Stress, Physiological; Transcription Factors | 2013 |
Large-scale global identification of protein lysine methylation in vivo.
Topics: Antibodies; HeLa Cells; Humans; Lysine; Methylation; Protein Transport; Proteins; Subcellular Fractions | 2013 |
Chromatin remodeling of human subtelomeres and TERRA promoters upon cellular senescence: commonalities and differences between chromosomes.
Topics: Biomarkers; Cellular Senescence; Chromatin Assembly and Disassembly; Chromosomes, Human; Euchromatin; Fibroblasts; Heterochromatin; Histones; Humans; Lysine; Methylation; Phenotype; Promoter Regions, Genetic; Repetitive Sequences, Nucleic Acid; RNA; Telomere; Telomere Shortening; Transcription, Genetic | 2013 |
Lysine trimethylation of EF-Tu mimics platelet-activating factor to initiate Pseudomonas aeruginosa pneumonia.
Topics: Adhesins, Bacterial; Animals; Bacterial Adhesion; Female; Lysine; Male; Methylation; Methyltransferases; Mice; Mice, Inbred BALB C; Peptide Elongation Factor Tu; Platelet Activating Factor; Pneumonia, Bacterial; Protein Processing, Post-Translational; Pseudomonas aeruginosa; Virulence Factors | 2013 |
De novo mutations in histone-modifying genes in congenital heart disease.
Topics: Adult; Case-Control Studies; Child; Chromatin; DNA Mutational Analysis; Enhancer Elements, Genetic; Exome; Female; Genes, Developmental; Heart Diseases; Histones; Humans; Lysine; Male; Methylation; Mutation; Odds Ratio; Promoter Regions, Genetic | 2013 |
ALKBH4-dependent demethylation of actin regulates actomyosin dynamics.
Topics: Actins; Actomyosin; AlkB Homolog 4, Lysine Demethylase; Animals; Carboxy-Lyases; Cell Line; Cell Movement; Cytokinesis; Dioxygenases; Embryo Loss; Gene Deletion; Genetic Complementation Test; Humans; Lysine; Methylation; Mice; Models, Biological; Protein Binding | 2013 |
Convergent evolution of chromatin modification by structurally distinct enzymes: comparative enzymology of histone H3 Lys²⁷ methylation by human polycomb repressive complex 2 and vSET.
Topics: Amino Acid Sequence; Biocatalysis; Chromatin; Histones; Humans; Lysine; Methylation; Methyltransferases; Molecular Sequence Data; Polycomb Repressive Complex 2; Protein Conformation; Sequence Homology, Amino Acid | 2013 |
Genetic identification of a novel locus, ACCELERATED FLOWERING 1 that controls chromatin modification associated with histone H3 lysine 27 trimethylation in Arabidopsis thaliana.
Topics: Arabidopsis; Arabidopsis Proteins; Chromatin; Epistasis, Genetic; Flowers; Gene Expression Regulation, Plant; Genes, Plant; Genetic Loci; Genetic Pleiotropy; Histones; Homeodomain Proteins; Lysine; Methylation; Mutation; Phenotype; Physical Chromosome Mapping | 2013 |
Regulation of transcription of nucleotide-binding leucine-rich repeat-encoding genes SNC1 and RPP4 via H3K4 trimethylation.
Topics: Arabidopsis; Arabidopsis Proteins; Cloning, Molecular; Gene Expression Regulation, Plant; Histones; Leucine-Rich Repeat Proteins; Lysine; Methylation; Methyltransferases; Mutation; Nuclear Proteins; Oomycetes; Plants, Genetically Modified; Promoter Regions, Genetic; Proteins; Repetitive Sequences, Amino Acid | 2013 |
Depleting the methyltransferase Suv39h1 improves DNA repair and extends lifespan in a progeria mouse model.
Topics: Animals; Disease Models, Animal; DNA Damage; DNA Repair; Enzyme Stability; Fibroblasts; HEK293 Cells; Heterochromatin; Histones; Humans; Lamin Type A; Longevity; Lysine; Methylation; Methyltransferases; Mice; Nuclear Proteins; Progeria; Protein Binding; Protein Precursors; Protein Processing, Post-Translational; Repressor Proteins | 2013 |
Dynamic methylation of Numb by Set8 regulates its binding to p53 and apoptosis.
Topics: Amino Acid Sequence; Antibiotics, Antineoplastic; Apoptosis; Binding Sites; Cell Line; Cell Line, Tumor; Doxorubicin; HeLa Cells; Histone-Lysine N-Methyltransferase; Humans; Immunoblotting; Lysine; MCF-7 Cells; Membrane Proteins; Methylation; Microscopy, Confocal; Mutation; Nerve Tissue Proteins; Protein Binding; RNA Interference; Signal Transduction; Tumor Suppressor Protein p53 | 2013 |
Multiple epigenetic mechanisms and the piRNA pathway enforce LINE1 silencing during adult spermatogenesis.
Topics: Age Factors; Animals; Argonaute Proteins; Blotting, Western; DNA Methylation; Epigenesis, Genetic; Gene Expression; Gene Silencing; Histones; Long Interspersed Nucleotide Elements; Lysine; Male; Methylation; Mice; Mice, Inbred C57BL; Mice, Knockout; Microscopy, Confocal; Mitosis; Reverse Transcriptase Polymerase Chain Reaction; RNA, Small Interfering; Signal Transduction; Spermatocytes; Spermatogenesis; Testis | 2013 |
A method for systematic mapping of protein lysine methylation identifies functions for HP1β in DNA damage response.
Topics: Catalytic Domain; Chromobox Protein Homolog 5; Chromosomal Proteins, Non-Histone; DNA Breaks, Double-Stranded; DNA Damage; DNA-Activated Protein Kinase; High-Throughput Screening Assays; Humans; Lysine; Methylation; Mutation; Protein Processing, Post-Translational; Proteins; Reproducibility of Results | 2013 |
KAT5 tyrosine phosphorylation couples chromatin sensing to ATM signalling.
Topics: Amino Acid Sequence; Animals; Ataxia Telangiectasia Mutated Proteins; Cell Cycle Checkpoints; Cell Cycle Proteins; Cell Line; Cell Survival; Chromatin; DNA Damage; DNA-Binding Proteins; Enzyme Activation; HeLa Cells; Histone Acetyltransferases; Histones; Humans; Lysine; Lysine Acetyltransferase 5; Methylation; Molecular Sequence Data; Phosphorylation; Phosphotyrosine; Protein Serine-Threonine Kinases; Proto-Oncogene Mas; Proto-Oncogene Proteins c-abl; Signal Transduction; Tumor Suppressor Proteins | 2013 |
Kdm4b histone demethylase is a DNA damage response protein and confers a survival advantage following γ-irradiation.
Topics: Animals; Ataxia Telangiectasia Mutated Proteins; Cell Line, Tumor; Cell Survival; DNA Breaks, Double-Stranded; DNA Damage; DNA Repair; DNA-Activated Protein Kinase; Fluorescence Recovery After Photobleaching; Gamma Rays; Green Fluorescent Proteins; Histones; Humans; Jumonji Domain-Containing Histone Demethylases; Lasers; Lysine; Methylation; Mice; Poly(ADP-ribose) Polymerases; Protein Transport; Recombinant Fusion Proteins | 2013 |
Mass spectrometry-based identification and characterisation of lysine and arginine methylation in the human proteome.
Topics: Arginine; Humans; Lysine; Mass Spectrometry; Methylation; Proteome; Proteomics | 2013 |
The Tudor protein survival motor neuron (SMN) is a chromatin-binding protein that interacts with methylated lysine 79 of histone H3.
Topics: Carrier Proteins; Centromere; Chromatin; HeLa Cells; Histones; Humans; Lysine; Methylation; Microscopy, Confocal; Nuclear Proteins; SMN Complex Proteins; Transfection | 2013 |
Application of reductive ¹³C-methylation of lysines to enhance the sensitivity of conventional NMR methods.
Topics: Calmodulin; Carbon Isotopes; Humans; Lysine; Methylation; Models, Molecular; Nuclear Magnetic Resonance, Biomolecular; Oxidation-Reduction; Prenylation; Protein Binding; Protein Conformation; Proto-Oncogene Proteins p21(ras); Sensitivity and Specificity | 2013 |
A small molecule modulates Jumonji histone demethylase activity and selectively inhibits cancer growth.
Topics: Aminopyridines; Animals; Antineoplastic Agents; Cell Line, Tumor; Cell Proliferation; Cell Survival; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Enzyme Inhibitors; Epigenesis, Genetic; Histones; Humans; Hydrazones; Inhibitory Concentration 50; Isomerism; Jumonji Domain-Containing Histone Demethylases; Lysine; Methylation; Mice; Neoplasms; Small Molecule Libraries; Survival Analysis; Transcription, Genetic | 2013 |
PHF20 regulates NF-κB signalling by disrupting recruitment of PP2A to p65.
Topics: Antigens, Neoplasm; Biomarkers, Tumor; Brain Neoplasms; DNA-Binding Proteins; Glioma; HEK293 Cells; HeLa Cells; Humans; Immunohistochemistry; Lysine; Methylation; Models, Biological; Phosphorylation; Protein Binding; Protein Phosphatase 2; Signal Transduction; Transcription Factor RelA; Transcription Factors; Tumor Necrosis Factor-alpha | 2013 |
Histone methylation at H3K9: evidence for a restrictive epigenome in schizophrenia.
Topics: Adult; Cerebral Cortex; Epigenomics; Female; Gene Expression Regulation; Histone-Lysine N-Methyltransferase; Histones; Humans; Linear Models; Lymphocytes; Lysine; Male; Methylation; Middle Aged; Postmortem Changes; Protein Methyltransferases; Psychiatric Status Rating Scales; RNA, Messenger; Schizophrenia | 2013 |
MicroRNA-323-3p regulates the activity of polycomb repressive complex 2 (PRC2) via targeting the mRNA of embryonic ectoderm development (Eed) gene in mouse embryonic stem cells.
Topics: 3' Untranslated Regions; Animals; Base Sequence; Embryo, Mammalian; Embryonic Stem Cells; Fibroblasts; Gene Expression Regulation, Developmental; Genes, Reporter; Hep G2 Cells; Histones; Humans; Induced Pluripotent Stem Cells; Luciferases; Lysine; Methylation; Mice; MicroRNAs; Molecular Sequence Data; Polycomb Repressive Complex 2; RNA, Messenger | 2013 |
PfSETvs methylation of histone H3K36 represses virulence genes in Plasmodium falciparum.
Topics: DNA-Binding Proteins; Drosophila Proteins; Erythrocytes; Gene Silencing; Genes, Protozoan; Histones; Introns; Lysine; Malaria Vaccines; Methylation; Plasmodium falciparum; Promoter Regions, Genetic; Protozoan Proteins; RNA, Long Noncoding; Transcription Factors; Transcription Initiation Site; Virulence; Virulence Factors | 2013 |
CpG islands under selective pressure are enriched with H3K4me3, H3K27ac and H3K36me3 histone modifications.
Topics: Acetylation; Cell Line; Chromatin; Computational Biology; CpG Islands; Epigenesis, Genetic; Evolution, Molecular; Histones; Humans; Lysine; Methylation; Promoter Regions, Genetic; Selection, Genetic | 2013 |
Identification of methyllysine peptides binding to chromobox protein homolog 6 chromodomain in the human proteome.
Topics: Chromosomal Proteins, Non-Histone; Humans; Lysine; Methylation; Models, Molecular; Peptides; Protein Processing, Post-Translational; Protein Structure, Tertiary; Proteome | 2013 |
Posttranslational modifications of the histone 3 tail and their impact on the activity of histone lysine demethylases in vitro.
Topics: Acetylation; Amino Acid Sequence; Enzyme Assays; Epigenesis, Genetic; Histone Demethylases; Histones; Humans; Kinetics; Lysine; Methylation; Molecular Docking Simulation; Molecular Dynamics Simulation; Molecular Sequence Data; Phosphorylation; Protein Processing, Post-Translational; Protein Structure, Tertiary; Recombinant Proteins; Signal Transduction; Substrate Specificity | 2013 |
Spt6 prevents transcription-coupled loss of posttranslationally modified histone H3.
Topics: Acetylation; Cell Cycle Proteins; Gene Order; Heterochromatin; Histone Chaperones; Histone Deacetylases; Histones; Lysine; Methylation; Models, Biological; Molecular Sequence Data; Mutation; Nucleosomes; Protein Processing, Post-Translational; Schizosaccharomyces; Schizosaccharomyces pombe Proteins; Transcription, Genetic | 2013 |
Chorion formation in panoistic ovaries requires windei and trimethylation of histone 3 lysine 9.
Topics: Animals; Chorion; Cloning, Molecular; Cockroaches; Drosophila melanogaster; Drosophila Proteins; Female; Histones; Lysine; Methylation; Ovary | 2014 |
Targeting H3K4 trimethylation in Huntington disease.
Topics: Animals; Animals, Genetically Modified; Blotting, Western; Brain; Brain-Derived Neurotrophic Factor; Cells, Cultured; Drosophila melanogaster; Female; Gene Expression Profiling; Histone Demethylases; Histones; Humans; Huntingtin Protein; Huntington Disease; Lysine; Male; Methylation; Mice; Mice, Inbred C57BL; Mice, Inbred CBA; Nerve Tissue Proteins; Neurons; Oxidoreductases, N-Demethylating; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference | 2013 |
Systemic lupus erythematosus patients contain significantly less igm against mono-methylated lysine than healthy subjects.
Topics: Adolescent; Child; Child, Preschool; Female; Histones; Humans; Immunoglobulin G; Immunoglobulin M; Lupus Erythematosus, Systemic; Lysine; Male; Methylation | 2013 |
Id2 complexes with the SNAG domain of Snai1 inhibiting Snai1-mediated repression of integrin β4.
Topics: Animals; Base Sequence; Binding Sites; Cadherins; Cell Line; Epithelial-Mesenchymal Transition; Gene Expression Profiling; Gene Expression Regulation; Histones; Humans; Inhibitor of Differentiation Protein 2; Integrin beta4; Lysine; MCF-7 Cells; Methylation; Mice; Molecular Sequence Data; Oligonucleotide Array Sequence Analysis; Promoter Regions, Genetic; Protein Binding; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Sequence Homology, Nucleic Acid; Snail Family Transcription Factors; Transcription Factors; Transforming Growth Factor beta1 | 2013 |
The CaMV 35S enhancer has a function to change the histone modification state at insertion loci in Arabidopsis thaliana.
Topics: Acetylation; Arabidopsis; Caulimovirus; Chromatin; Chromatin Immunoprecipitation; Enhancer Elements, Genetic; Epigenomics; Gene Expression Regulation, Plant; Gene Silencing; Genes, Reporter; Histones; Lysine; Methylation; Mutation; Plant Leaves; Plants, Genetically Modified | 2013 |
Folate polyglutamylation is involved in chromatin silencing by maintaining global DNA methylation and histone H3K9 dimethylation in Arabidopsis.
Topics: Arabidopsis; Arabidopsis Proteins; Base Sequence; Chromatin; Chromosomes, Plant; DNA Methylation; DNA-Binding Proteins; Folic Acid; Gene Expression Regulation, Plant; Gene Silencing; Genetic Complementation Test; Histones; Immunoblotting; Kanamycin Kinase; Lysine; Methylation; Microscopy, Confocal; Molecular Sequence Data; Mutation; Nuclear Proteins; Peptide Synthases; Plants, Genetically Modified; Polyglutamic Acid; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; Transcription Factors | 2013 |
Effects of lysine methylation on gramicidin A channel folding in lipid membranes.
Topics: Amino Acid Sequence; Gramicidin; Hydrogen Bonding; Lipid Bilayers; Lysine; Methylation | 2013 |
BGDB: a database of bivalent genes.
Topics: Animals; Chromosomes, Human; Databases, Genetic; Embryonic Stem Cells; Genes; Histones; Humans; Lysine; Methylation; Mice; Molecular Sequence Annotation; PubMed | 2013 |
A dual role for SAGA-associated factor 29 (SGF29) in ER stress survival by coordination of both histone H3 acetylation and histone H3 lysine-4 trimethylation.
Topics: Acetylation; Acetyltransferases; Bone Neoplasms; Cell Line, Tumor; Cell Survival; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Gene Knockdown Techniques; Histones; Humans; Lysine; Methylation; Osteosarcoma; Promoter Regions, Genetic; Transcription Factor CHOP; Transcription, Genetic | 2013 |
DNMT1 is regulated by ATP-citrate lyase and maintains methylation patterns during adipocyte differentiation.
Topics: 3T3-L1 Cells; Adipocytes; Animals; ATP Citrate (pro-S)-Lyase; Blotting, Western; Cell Differentiation; Cell Line; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Gene Expression; HEK293 Cells; Histones; Humans; Lysine; Methylation; Mice; MicroRNAs; Mitosis; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference | 2013 |
Role of lysine methylation of NF-κB in differential gene regulation.
Topics: Blotting, Western; Chromatin Immunoprecipitation; Cytokines; DNA Primers; F-Box Proteins; Gene Expression Regulation; HEK293 Cells; Humans; Interleukin-1beta; Jumonji Domain-Containing Histone Demethylases; Lysine; Methylation; Microarray Analysis; Mutagenesis, Site-Directed; Mutation; NF-kappa B; Oxidoreductases, N-Demethylating; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; Sequence Analysis, DNA | 2013 |
PHD domain from human SHPRH.
Topics: Amino Acid Motifs; Amino Acid Sequence; Chromatin Assembly and Disassembly; DNA Helicases; Histones; Humans; Lysine; Methylation; Molecular Sequence Data; Nuclear Magnetic Resonance, Biomolecular; Protein Structure, Tertiary; Thermodynamics; Ubiquitin-Protein Ligases | 2013 |
H4K20 methylation regulates quiescence and chromatin compaction.
Topics: Cell Cycle; Cell Proliferation; Chromatin; DNA Replication; Fibroblasts; Gene Knockdown Techniques; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Mitosis; Primary Cell Culture | 2013 |
Tissue-specific epigenetic modifications in root apical meristem cells of Hordeum vulgare.
Topics: Acetylation; Cell Nucleus; Cytoplasm; DNA Methylation; Epigenesis, Genetic; Histones; Hordeum; Immunohistochemistry; Lysine; Meristem; Methylation; Microscopy, Confocal; Plant Epidermis; Plant Proteins; Plant Roots; Plant Vascular Bundle | 2013 |
Telomeric repeats facilitate CENP-A(Cnp1) incorporation via telomere binding proteins.
Topics: Blotting, Western; Centromere; Chromatin; Chromosomal Proteins, Non-Histone; Chromosomes, Fungal; DNA, Ribosomal; Gene Expression Profiling; Gene Expression Regulation, Fungal; Heterochromatin; Histones; Lysine; Methylation; Repetitive Sequences, Nucleic Acid; Schizosaccharomyces; Schizosaccharomyces pombe Proteins; Telomere; Telomere-Binding Proteins | 2013 |
Role of histone lysine methyltransferases SUV39H1 and SETDB1 in gliomagenesis: modulation of cell proliferation, migration, and colony formation.
Topics: Apoptosis; Astrocytoma; Biomarkers, Tumor; Brain Neoplasms; Cell Division; Cell Line, Tumor; Cell Movement; Enzyme Induction; Glioblastoma; Histone-Lysine N-Methyltransferase; Humans; Lysine; Methylation; Methyltransferases; Neoplasm Grading; Neoplasm Proteins; Protein Methyltransferases; Protein Processing, Post-Translational; Repressor Proteins; RNA Interference; RNA, Small Interfering; Tumor Stem Cell Assay; Up-Regulation | 2014 |
Automethylation of protein arginine methyltransferase 8 (PRMT8) regulates activity by impeding S-adenosylmethionine sensitivity.
Topics: Catalysis; HeLa Cells; Humans; Lysine; Membrane Proteins; Methylation; Mutagenesis, Site-Directed; Mutation; Phenylalanine; Protein Binding; Protein Processing, Post-Translational; Protein Structure, Tertiary; Protein-Arginine N-Methyltransferases; S-Adenosylmethionine | 2013 |
The Tudor domain of the PHD finger protein 1 is a dual reader of lysine trimethylation at lysine 36 of histone H3 and lysine 27 of histone variant H3t.
Topics: Amino Acid Sequence; Binding Sites; DNA-Binding Proteins; Genetic Variation; HEK293 Cells; Histones; Humans; Lysine; Methylation; Molecular Sequence Data; Mutagenesis, Site-Directed; Polycomb Repressive Complex 2; Polycomb-Group Proteins; Protein Binding; Protein Interaction Domains and Motifs; Recombinant Proteins; Sequence Homology, Amino Acid; Transcription Factors | 2014 |
PINK1 regulates histone H3 trimethylation and gene expression by interaction with the polycomb protein EED/WAIT1.
Topics: Animals; Antineoplastic Agents; Binding Sites; Cell Differentiation; Cell Line, Tumor; Chlorocebus aethiops; COS Cells; Gene Expression Regulation; HEK293 Cells; Histones; Humans; Immunoblotting; Lysine; Methylation; Mitochondria; Neuroblastoma; Phosphorylation; Polycomb Repressive Complex 2; Protein Binding; Protein Kinases; Protein Transport; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Tretinoin; Two-Hybrid System Techniques | 2013 |
SUMOylation negatively modulates target gene occupancy of the KDM5B, a histone lysine demethylase.
Topics: Animals; Cell Line; Histones; Humans; Jumonji Domain-Containing Histone Demethylases; Lysine; Methylation; Mice; Neoplasm Proteins; Nuclear Proteins; Protein Processing, Post-Translational; Repressor Proteins; Small Ubiquitin-Related Modifier Proteins; Sumoylation | 2013 |
Investigation of lysine side chain interactions of interleukin-8 with heparin and other glycosaminoglycans studied by a methylation-NMR approach.
Topics: Amino Acid Substitution; Animals; Chlorocebus aethiops; COS Cells; Glycosaminoglycans; Heparin; Interleukin-8; Lysine; Magnetic Resonance Spectroscopy; Methylation; Molecular Dynamics Simulation; Oxidation-Reduction; Protein Binding; Receptors, Interleukin-8A; Signal Transduction; Solutions | 2013 |
Functional specificity of CpG DNA-binding CXXC domains in mixed lineage leukemia.
Topics: Amino Acid Sequence; Animals; Binding Sites; Cell Line; Cells, Cultured; Chromatin Immunoprecipitation; CpG Islands; DNA; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA-Binding Proteins; Histone-Lysine N-Methyltransferase; Histones; Homeodomain Proteins; Humans; Leukemia, Experimental; Lysine; Methylation; Mice; Molecular Sequence Data; Myeloid-Lymphoid Leukemia Protein; Oncogene Proteins, Fusion; Protein Binding; Sequence Homology, Amino Acid; Transcription Factors | 2013 |
Substrate-induced transcriptional activation of the MoCel7C cellulase gene is associated with methylation of histone H3 at lysine 4 in the rice blast fungus Magnaporthe oryzae.
Topics: Base Sequence; Blotting, Western; Cellulase; Chromatin Immunoprecipitation; DNA Primers; Gene Knockout Techniques; Genes, Fungal; Genetic Vectors; Green Fluorescent Proteins; Histones; Lysine; Magnaporthe; Methylation; Molecular Sequence Data; Real-Time Polymerase Chain Reaction; Sequence Analysis, DNA; Transcriptional Activation | 2013 |
[Identification of methylation at lysine 27 and 36 sites in histone H3].
Topics: Chromatography, Liquid; Histones; Lysine; Methylation; Tandem Mass Spectrometry | 2013 |
N-alpha-terminal acetylation of histone H4 regulates arginine methylation and ribosomal DNA silencing.
Topics: Acetylation; Acetyltransferases; Arginine; Chromatin; DNA, Ribosomal; Gene Silencing; Histones; Lysine; Methylation; Mutation; Protein Processing, Post-Translational; Saccharomyces cerevisiae; Substrate Specificity | 2013 |
Modulation of lysine methylation in myocyte enhancer factor 2 during skeletal muscle cell differentiation.
Topics: Animals; Cell Differentiation; Cell Line; Chromatin; HEK293 Cells; Histone Demethylases; Histone-Lysine N-Methyltransferase; Humans; Lysine; MEF2 Transcription Factors; Methylation; Mice; Myoblasts, Skeletal; Oxidoreductases, N-Demethylating; Protein Processing, Post-Translational; Transcription, Genetic | 2014 |
The signal transducers Stat1 and Stat3 and their novel target Jmjd3 drive the expression of inflammatory genes in microglia.
Topics: Animals; Cells, Cultured; Chromatin Immunoprecipitation; Cytokines; Gene Expression Regulation; Gene Silencing; Histones; Inflammation; Jumonji Domain-Containing Histone Demethylases; Lipopolysaccharides; Lysine; Methylation; Microglia; Phosphorylation; Polymerase Chain Reaction; Promoter Regions, Genetic; Rats; Rats, Wistar; STAT1 Transcription Factor; STAT3 Transcription Factor | 2014 |
Regulation of estrogen receptor α by histone methyltransferase SMYD2-mediated protein methylation.
Topics: Acetylation; Amino Acid Sequence; Blotting, Western; Cell Line, Tumor; Chromatin; Estradiol; Estrogen Receptor alpha; Estrogens; Gene Expression Regulation, Neoplastic; Histone Demethylases; Histone-Lysine N-Methyltransferase; Humans; Lysine; MCF-7 Cells; Methylation; Mutation; p300-CBP Transcription Factors; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Sequence Homology, Amino Acid | 2013 |
Dynamics of DOT1L localization and H3K79 methylation during meiotic prophase I in mouse spermatocytes.
Topics: Animals; Cell Nucleus; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Male; Meiotic Prophase I; Methylation; Methyltransferases; Mice; Mice, Inbred C57BL; Models, Biological; Mutation; Protein Transport; Sex Chromosomes; Spermatocytes; Time Factors | 2014 |
EZH2 and KDM6A act as an epigenetic switch to regulate mesenchymal stem cell lineage specification.
Topics: Adipocytes; Adipogenesis; Adolescent; Adult; Animals; Cell Lineage; Cells, Cultured; Enhancer of Zeste Homolog 2 Protein; Epigenesis, Genetic; Gene Expression Regulation; Gene Knockdown Techniques; Histone Demethylases; Histones; Humans; Lysine; Mesenchymal Stem Cells; Methylation; Mice; Mice, SCID; Nuclear Proteins; Osteoblasts; Osteogenesis; Polycomb Repressive Complex 2; Promoter Regions, Genetic; Transcription, Genetic; Young Adult | 2014 |
Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.
Topics: Amino Acid Motifs; Animals; Arginine; Brain; Chromatography, Liquid; HCT116 Cells; Humans; Lysine; Methylation; Mice; Protein Processing, Post-Translational; Tandem Mass Spectrometry | 2014 |
Negative regulation of interferon-induced transmembrane protein 3 by SET7-mediated lysine monomethylation.
Topics: Amino Acid Sequence; Animals; Cell Line; Chlorocebus aethiops; Gene Knockdown Techniques; HEK293 Cells; Histone-Lysine N-Methyltransferase; Humans; Influenza A virus; Interferon Type I; Lysine; Membrane Proteins; Methylation; Molecular Sequence Data; Protein Processing, Post-Translational; RNA-Binding Proteins; Signal Transduction; Vero Cells; Vesiculovirus; Virus Diseases | 2013 |
H3K4 demethylase activities repress proliferative and postmitotic aging.
Topics: Animals; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Cell Proliferation; Cellular Senescence; Fertility; Germ Cells; Heterozygote; Histone Demethylases; Histones; Longevity; Lysine; Methylation; Mitosis; Mutation; Phenotype; Retinoblastoma-Binding Protein 2; Temperature | 2014 |
Epigenetic upregulation of CCL2 and CCL3 via histone modifications in infiltrating macrophages after peripheral nerve injury.
Topics: Acetylation; Animals; Bone Marrow Transplantation; Chemokine CCL2; Chemokine CCL3; Epigenesis, Genetic; Histones; Immunohistochemistry; Lysine; Macrophages; Male; Methylation; Mice; Mice, Inbred C57BL; Mice, Inbred ICR; Mice, Transgenic; Neuralgia; Peripheral Nerve Injuries; Receptors, CCR1; Receptors, CCR2; Receptors, CCR5; Reverse Transcriptase Polymerase Chain Reaction; Sciatic Nerve; Time Factors; Up-Regulation | 2013 |
The effect of N-acetylation and N-methylation of lysine residue of Tat peptide on its interaction with HIV-1 TAR RNA.
Topics: Acetylation; Amino Acid Sequence; Base Sequence; Circular Dichroism; HIV Long Terminal Repeat; HIV-1; Humans; Kinetics; Lysine; Methylation; Peptides; Protein Binding; RNA, Viral; tat Gene Products, Human Immunodeficiency Virus; Thermodynamics | 2013 |
High-resolution Xist binding maps reveal two-step spreading during X-chromosome inactivation.
Topics: Animals; Chromatin; Embryonic Stem Cells; Female; Fibroblasts; Gene Silencing; Genes; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Mice; Models, Genetic; RNA, Long Noncoding; X Chromosome; X Chromosome Inactivation | 2013 |
In situ histone landscape of nephrogenesis.
Topics: Animals; Arginine; Cell Differentiation; Chromatin; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Kidney; Lysine; Methylation; Mice; Nephrons; Organogenesis; Stem Cells | 2014 |
LSD1 regulates pluripotency of embryonic stem/carcinoma cells through histone deacetylase 1-mediated deacetylation of histone H4 at lysine 16.
Topics: Acetylation; Animals; Cell Proliferation; Co-Repressor Proteins; Embryonal Carcinoma Stem Cells; Embryonic Stem Cells; Epigenesis, Genetic; G1 Phase Cell Cycle Checkpoints; Gene Expression; HCT116 Cells; HeLa Cells; Histone Acetyltransferases; Histone Deacetylase 1; Histone Demethylases; Histones; Humans; Lysine; Methylation; Mice; Nerve Tissue Proteins; NIH 3T3 Cells; Octamer Transcription Factor-3; Protein Processing, Post-Translational; Repressor Proteins; Sirtuin 1; SOXB1 Transcription Factors | 2014 |
Latrunculin A treatment prevents abnormal chromosome segregation for successful development of cloned embryos.
Topics: Actins; Animals; Azepines; Bridged Bicyclo Compounds, Heterocyclic; Chromosome Segregation; Cloning, Organism; Embryo, Mammalian; Embryonic Development; Epigenesis, Genetic; Female; Fertilization in Vitro; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Nuclear Transfer Techniques; Oocytes; Quinazolines; Thiazolidines | 2013 |
Automethylation activities within the mixed lineage leukemia-1 (MLL1) core complex reveal evidence supporting a "two-active site" model for multiple histone H3 lysine 4 methylation.
Topics: Amino Acid Substitution; Animals; Binding Sites; Cysteine; DNA-Binding Proteins; Electrophoresis, Polyacrylamide Gel; Histone-Lysine N-Methyltransferase; Histones; Humans; Intracellular Signaling Peptides and Proteins; Kinetics; Lysine; Mass Spectrometry; Methylation; Models, Molecular; Mutation; Myeloid-Lymphoid Leukemia Protein; Nuclear Proteins; Protein Structure, Tertiary; Transcription Factors | 2014 |
Ash1l methylates Lys36 of histone H3 independently of transcriptional elongation to counteract polycomb silencing.
Topics: Animals; Chromatin; Dichlororibofuranosylbenzimidazole; DNA-Binding Proteins; Drosophila melanogaster; Drosophila Proteins; Gene Silencing; Histone Acetyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Nuclear Proteins; Polycomb-Group Proteins; Positive Transcriptional Elongation Factor B; RNA Polymerase II; Transcription Factors; Transcription, Genetic; Transcriptional Elongation Factors | 2013 |
Mammalian protein arginine methyltransferase 7 (PRMT7) specifically targets RXR sites in lysine- and arginine-rich regions.
Topics: Amino Acid Motifs; Animals; Arginine; Histones; Humans; Lysine; Methylation; Mice; Protein Processing, Post-Translational; Protein-Arginine N-Methyltransferases; Recombinant Proteins; Sf9 Cells; Spodoptera; Substrate Specificity | 2013 |
Mammary-specific gene activation is defined by progressive recruitment of STAT5 during pregnancy and the establishment of H3K4me3 marks.
Topics: Animals; Animals, Newborn; Chromatin; Epithelium; Female; Gene Expression Regulation, Developmental; Gene Ontology; Histones; Lysine; Mammary Glands, Animal; Methylation; Mice; Oligonucleotide Array Sequence Analysis; Phosphorylation; Pregnancy; Promoter Regions, Genetic; Protein Binding; STAT5 Transcription Factor; Transcriptional Activation; Transcriptome | 2014 |
Jumonji C domain protein JMJ705-mediated removal of histone H3 lysine 27 trimethylation is involved in defense-related gene activation in rice.
Topics: Gene Expression Regulation, Plant; Histones; Jumonji Domain-Containing Histone Demethylases; Lysine; Methylation; Oryza; Plants, Genetically Modified; Xanthomonas | 2013 |
Lysine methylation promotes VEGFR-2 activation and angiogenesis.
Topics: Animals; Cell Line, Tumor; HEK293 Cells; Heterografts; Humans; Lysine; Methylation; Mice; Neoplasm Proteins; Neoplasm Transplantation; Neoplasms; Neovascularization, Pathologic; Protein Processing, Post-Translational; Vascular Endothelial Growth Factor Receptor-2; Zebrafish; Zebrafish Proteins | 2013 |
Proteome-wide enrichment of proteins modified by lysine methylation.
Topics: Chromatography, Liquid; Escherichia coli; Lysine; Methylation; Proteins; Proteomics; Tandem Mass Spectrometry | 2014 |
A novel microscopy-based high-throughput screening method to identify proteins that regulate global histone modification levels.
Topics: Cell Line; Chromatin; Epigenesis, Genetic; High-Throughput Screening Assays; Histones; Humans; Lysine; Methylation; Microscopy; Protein Binding; Protein Processing, Post-Translational; Proteins | 2014 |
Hairless is a histone H3K9 demethylase.
Topics: Basic Helix-Loop-Helix Transcription Factors; Binding Sites; Blotting, Western; Caspase 14; Cells, Cultured; Chromatin Immunoprecipitation; Gene Expression Regulation; HEK293 Cells; HeLa Cells; Histone Demethylases; Histones; Humans; Jumonji Domain-Containing Histone Demethylases; Lysine; Methylation; Models, Molecular; Mutation; Promoter Regions, Genetic; Protein Structure, Tertiary; Reverse Transcriptase Polymerase Chain Reaction; Sequence Analysis, DNA; Transcription Factors; Tumor Suppressor Proteins | 2014 |
ChIP-seq analysis of histone H3K9 trimethylation in peripheral blood mononuclear cells of membranous nephropathy patients.
Topics: Adult; Case-Control Studies; Chromatin Immunoprecipitation; Female; Glomerulonephritis, Membranous; Histones; Humans; Leukocytes, Mononuclear; Lysine; Male; Methylation | 2014 |
PPARβ interprets a chromatin signature of pluripotency to promote embryonic differentiation at gastrulation.
Topics: Animals; Base Sequence; Blastula; Cell Differentiation; Chromatin; Epigenesis, Genetic; Gastrulation; Gene Knockdown Techniques; Histones; Lysine; Methylation; PPAR-beta; RNA, Messenger; Transcriptome; Xenopus laevis | 2013 |
An epigenetic profile of early T-cell development from multipotent progenitors to committed T-cell descendants.
Topics: Animals; Cell Differentiation; Cell Lineage; Cells, Cultured; Cluster Analysis; Epigenesis, Genetic; Epigenomics; Hematopoietic Stem Cells; Histones; Lysine; Methylation; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Knockout; Multipotent Stem Cells; Oligonucleotide Array Sequence Analysis; Precursor Cells, T-Lymphoid; T-Lymphocytes | 2014 |
Quantitative proteomics reveals histone modifications in crosstalk with H3 lysine 27 methylation.
Topics: Acetylation; DNA Damage; DNA, Ribosomal; Electrophoresis, Polyacrylamide Gel; Epigenesis, Genetic; Histones; Lysine; Methylation; Mutation; Protein Processing, Post-Translational; Protein Structure, Tertiary; Proteomics; Protozoan Proteins; Reproducibility of Results; Stress, Physiological; Tetrahymena | 2014 |
Context dependency of Set1/COMPASS-mediated histone H3 Lys4 trimethylation.
Topics: Histone-Lysine N-Methyltransferase; Histones; Lysine; Membrane Proteins; Methylation; Phosphoric Monoester Hydrolases; Protein Stability; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins | 2014 |
Substrate specificity analysis and novel substrates of the protein lysine methyltransferase NSD1.
Topics: Amino Acid Sequence; HEK293 Cells; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; Intracellular Signaling Peptides and Proteins; Lysine; Methylation; Nuclear Proteins; Peptides; Protein Structure, Tertiary; Recombinant Fusion Proteins; Substrate Specificity | 2014 |
Lysine methylation of progesterone receptor at activation function 1 regulates both ligand-independent activity and ligand sensitivity of the receptor.
Topics: Amino Acid Substitution; Animals; Chlorocebus aethiops; COS Cells; Humans; Ligands; Lysine; Methylation; Mutation, Missense; Nuclear Receptor Co-Repressor 1; Phosphorylation; Protein Isoforms; Receptors, Progesterone | 2014 |
Mll2 is required for H3K4 trimethylation on bivalent promoters in embryonic stem cells, whereas Mll1 is redundant.
Topics: Animals; Binding Sites; Cell Differentiation; Chromosomes, Artificial, Bacterial; Embryonic Stem Cells; Gene Expression Profiling; Gene Expression Regulation, Developmental; Genome; Histone-Lysine N-Methyltransferase; Histones; Homeodomain Proteins; Lysine; Methylation; Mice; Models, Biological; Myeloid-Lymphoid Leukemia Protein; Promoter Regions, Genetic; Protein Binding; Transgenes; Tretinoin | 2014 |
On form and function: does chromatin packing regulate the cell cycle?
Topics: Cell Cycle; Cell Proliferation; Chromatin; Epigenesis, Genetic; Fibroblasts; Gene Expression; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Models, Genetic; RNA Interference; Signal Transduction | 2014 |
The lysine-specific demethylase 1 is a novel substrate of protein kinase CK2.
Topics: Amino Acid Sequence; Animals; Casein Kinase II; Cell Line, Tumor; Drosophila melanogaster; Epigenesis, Genetic; Escherichia coli; Histone Demethylases; Histones; Humans; Lysine; Methylation; Molecular Sequence Data; Mutation; Neurons; Phosphorylation; Protein Structure, Tertiary; Protein Subunits; Recombinant Proteins; Serine; Signal Transduction | 2014 |
The methyltransferase WBSCR22/Merm1 enhances glucocorticoid receptor function and is regulated in lung inflammation and cancer.
Topics: B-Lymphocytes; Bronchi; CD8-Positive T-Lymphocytes; Cell Line, Tumor; Chromatin Assembly and Disassembly; Epithelium; Gene Expression Regulation, Neoplastic; Glucocorticoids; Histones; Humans; Inflammation; Interferon-gamma; Lung Neoplasms; Lysine; Methylation; Methyltransferases; Protein Binding; Protein Kinases; Protein Structure, Tertiary; Receptors, Glucocorticoid; RNA, Messenger; Signal Transduction; Transcriptional Activation; Tumor Necrosis Factor-alpha; Ubiquitination | 2014 |
Broad shifts in gene expression during early postnatal life are associated with shifts in histone methylation patterns.
Topics: Aging; Animals; Animals, Newborn; Cell Cycle; Cell Differentiation; Chromatin Immunoprecipitation; Gene Expression Profiling; Gene Expression Regulation, Developmental; Gene Ontology; Histones; Kidney; Lung; Lysine; Male; Methylation; Mice, Inbred C57BL; Neurons; Protein Processing, Post-Translational; Reproducibility of Results; Reverse Transcriptase Polymerase Chain Reaction; Time Factors | 2014 |
Multimethylation of Rickettsia OmpB catalyzed by lysine methyltransferases.
Topics: Amino Acid Motifs; Bacterial Outer Membrane Proteins; Cell Membrane; Chromatography, Liquid; Kinetics; Lysine; Methylation; Methyltransferases; Plasmids; Protein Structure, Tertiary; Rickettsia prowazekii; Rickettsia typhi; Tandem Mass Spectrometry; Virulence | 2014 |
Loss of histone H3 methylation at lysine 4 triggers apoptosis in Saccharomyces cerevisiae.
Topics: Apoptosis; Cell Survival; DNA Damage; Histone-Lysine N-Methyltransferase; Histones; Jumonji Domain-Containing Histone Demethylases; Lysine; Methylation; Nuclear Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Ubiquitination | 2014 |
Arsenite induces premature senescence via p53/p21 pathway as a result of DNA damage in human malignant glioblastoma cells.
Topics: Arsenites; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cellular Senescence; Cyclin-Dependent Kinase Inhibitor p21; DNA Damage; Glioblastoma; Histones; Humans; Lysine; Methylation; Signal Transduction; Tumor Suppressor Protein p53 | 2014 |
Tomato GOLDEN2-LIKE transcription factors reveal molecular gradients that function during fruit development and ripening.
Topics: Carotenoids; Chlorophyll; Chloroplasts; Ethylenes; Fruit; Gene Expression Profiling; Gene Expression Regulation, Developmental; Gene Expression Regulation, Plant; Genes, Plant; Histones; Lysine; Methylation; Mutation; Organ Specificity; Phenotype; Photosynthesis; Plant Leaves; Plant Proteins; Plants, Genetically Modified; Solanum lycopersicum; Transcription Factors | 2014 |
Stoichiometry of Saccharomyces cerevisiae lysine methylation: insights into non-histone protein lysine methyltransferase activity.
Topics: Amino Acid Sequence; Lysine; Methylation; Methyltransferases; Molecular Sequence Data; Peptide Elongation Factor 1; Peptide Elongation Factor 2; Protein Processing, Post-Translational; Ribosomal Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins | 2014 |
Protein methylation and interaction with the antiproliferative gene, BTG2/TIS21/Pc3.
Topics: Animals; Apoptosis; Arginine; Biochemistry; Cell Differentiation; DNA Damage; History, 20th Century; Humans; Immediate-Early Proteins; Lysine; Methylation; Neurites; Protein-Arginine N-Methyltransferases; Proteins; Repressor Proteins; Tumor Suppressor Proteins | 2014 |
Identification and characterization of lysine-methylated sites on histones and non-histone proteins.
Topics: Animals; Databases, Protein; Humans; Lysine; Methylation; Mice; Protein Processing, Post-Translational; Proteins; Support Vector Machine | 2014 |
Histone H3K9 and H3K27 methylation regulates fungal alkaloid biosynthesis in a fungal endophyte-plant symbiosis.
Topics: Alkaloids; Chromatin Immunoprecipitation; DNA, Fungal; Endophytes; Epichloe; Gene Deletion; Gene Expression Profiling; Gene Expression Regulation, Fungal; Histones; Lolium; Lysine; Methylation; Methyltransferases; Molecular Sequence Data; Protein Processing, Post-Translational; Real-Time Polymerase Chain Reaction; Sequence Analysis, DNA; Symbiosis; Transcription, Genetic | 2014 |
Inhibition of histone binding by supramolecular hosts.
Topics: Autoantigens; Calixarenes; Chromatin Assembly and Disassembly; Chromosomal Proteins, Non-Histone; Drug Design; Epigenesis, Genetic; HEK293 Cells; Histones; Homeodomain Proteins; Humans; Hypoxia-Inducible Factor-Proline Dioxygenases; Indicators and Reagents; Lysine; Methylation; Mi-2 Nucleosome Remodeling and Deacetylase Complex; Models, Molecular; Peptide Fragments; Protein Interaction Domains and Motifs; Protein Processing, Post-Translational; Protein Subunits; Recombinant Proteins | 2014 |
Statistical mechanics model for the dynamics of collective epigenetic histone modification.
Topics: Epigenomics; Histones; Lysine; Methylation; Models, Genetic; Models, Statistical; Nucleosomes; Octamer Transcription Factor-3; Stochastic Processes; Thermodynamics | 2014 |
ZMYND11 links histone H3.3K36me3 to transcription elongation and tumour suppression.
Topics: Amino Acid Sequence; Animals; Breast Neoplasms; Carrier Proteins; Cell Cycle Proteins; Chromatin; Co-Repressor Proteins; Crystallography, X-Ray; Disease-Free Survival; DNA-Binding Proteins; Female; Gene Expression Regulation, Neoplastic; Histones; Humans; Lysine; Methylation; Mice; Mice, Nude; Models, Molecular; Molecular Sequence Data; Oncogenes; Prognosis; Protein Binding; Protein Conformation; Protein Structure, Tertiary; RNA Polymerase II; Substrate Specificity; Transcription Elongation, Genetic | 2014 |
Structural insights into estrogen receptor α methylation by histone methyltransferase SMYD2, a cellular event implicated in estrogen signaling regulation.
Topics: Amino Acid Sequence; Binding Sites; Crystallography, X-Ray; Electrophoresis, Polyacrylamide Gel; Estrogen Receptor alpha; Estrogens; Ethylene Glycol; Histone-Lysine N-Methyltransferase; Humans; Lysine; Methylation; Models, Molecular; Mutation; Protein Binding; Protein Structure, Tertiary; Sequence Homology, Amino Acid; Signal Transduction; Substrate Specificity | 2014 |
Concurrent activation of acetylation and tri-methylation of H3K27 in a subset of hepatocellular carcinoma with aggressive behavior.
Topics: Acetylation; beta Catenin; Carcinoma, Hepatocellular; Fluorescent Antibody Technique; Hepatectomy; Histones; Humans; Kaplan-Meier Estimate; Liver Neoplasms; Lysine; Methylation; Multivariate Analysis; Neoplasm Invasiveness; Treatment Outcome; Tumor Suppressor Protein p53 | 2014 |
Lysine methylation mapping of crenarchaeal DNA-directed RNA polymerases by collision-induced and electron-transfer dissociation mass spectrometry.
Topics: Acetylation; Amino Acid Sequence; Archaeal Proteins; Binding Sites; Chromatography, Liquid; DNA-Directed RNA Polymerases; Electron Transport; Electrophoresis, Polyacrylamide Gel; Lysine; Mass Spectrometry; Methylation; Molecular Sequence Data; Protein Subunits; Sequence Homology, Amino Acid; Species Specificity; Sulfolobus; Sulfolobus acidocaldarius | 2014 |
Histone H3 lysine 4 trimethylation regulates cotranscriptional H2A variant exchange by Tip60 complexes to maximize gene expression.
Topics: Acetylation; Animals; DNA Polymerase II; DNA-Binding Proteins; Drosophila melanogaster; Drosophila Proteins; Gene Expression Regulation; Genetic Loci; Heat Shock Transcription Factors; Histone Acetyltransferases; Histone-Lysine N-Methyltransferase; Histones; HSP70 Heat-Shock Proteins; Lysine; Methylation; Models, Biological; Multiprotein Complexes; Nucleosomes; Promoter Regions, Genetic; Protein Binding; RNA, Messenger; Transcription Factors; Transcription Initiation Site; Transcription, Genetic; Transcriptional Activation | 2014 |
The localization of histone H3K27me3 demethylase Jmjd3 is dynamically regulated.
Topics: Active Transport, Cell Nucleus; Animals; Catalytic Domain; Cell Nucleus; Cells, Cultured; Fatty Acids, Unsaturated; Histones; Humans; Jumonji Domain-Containing Histone Demethylases; Karyopherins; Lysine; Methylation; Mice; Nuclear Localization Signals | 2014 |
Arabidopsis guard cell integrity involves the epigenetic stabilization of the FLP and FAMA transcription factor genes.
Topics: Arabidopsis; Arabidopsis Proteins; Basic Helix-Loop-Helix Transcription Factors; Cell Lineage; Epigenesis, Genetic; Gene Expression Regulation, Plant; Green Fluorescent Proteins; Histones; Homeodomain Proteins; Lysine; Methylation; Microscopy, Confocal; Phenotype; Plant Stomata; Plants, Genetically Modified; Reverse Transcriptase Polymerase Chain Reaction; Stem Cells; Transcription Factors | 2014 |
Acetylation of histone H3 at lysine 64 regulates nucleosome dynamics and facilitates transcription.
Topics: Acetylation; Animals; Chromatin Assembly and Disassembly; Embryonic Stem Cells; Histones; Humans; Kinetics; Lysine; Male; Methylation; Mice; Neural Stem Cells; NIH 3T3 Cells; Nucleic Acid Conformation; Nucleosomes; p300-CBP Transcription Factors; Protein Conformation; Protein Processing, Post-Translational; Protein Stability; Transcription, Genetic; Transcriptional Activation; Transfection; Xenopus laevis; Xenopus Proteins | 2014 |
Uncoupling transcription from covalent histone modification.
Topics: Acetylation; Heterochromatin; Histones; HSP90 Heat-Shock Proteins; Lysine; Methylation; Nucleosomes; Promoter Regions, Genetic; RNA Polymerase II; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Transcription, Genetic; Transcriptional Activation | 2014 |
The histone methyltransferase SMYD2 methylates PARP1 and promotes poly(ADP-ribosyl)ation activity in cancer cells.
Topics: Amino Acid Sequence; DNA Damage; HeLa Cells; Histone-Lysine N-Methyltransferase; Humans; Hydrogen Peroxide; Lysine; Methylation; Molecular Sequence Data; Poly (ADP-Ribose) Polymerase-1; Poly Adenosine Diphosphate Ribose; Poly(ADP-ribose) Polymerases; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2014 |
CtBP and associated LSD1 are required for transcriptional activation by NeuroD1 in gastrointestinal endocrine cells.
Topics: Acetylation; Alcohol Oxidoreductases; Animals; Basic Helix-Loop-Helix Transcription Factors; Cell Line; DNA-Binding Proteins; Enteroendocrine Cells; Histone Demethylases; Histones; Humans; Lysine; Methylation; Models, Biological; Nerve Tissue Proteins; p300-CBP Transcription Factors; Promoter Regions, Genetic; Protein Binding; Secretin; Transcription Factors; Transcription, Genetic; Transcriptional Activation | 2014 |
Domains of genome-wide gene expression dysregulation in Down's syndrome.
Topics: Animals; Cells, Cultured; Chromatin; Chromosomes, Human, Pair 21; Chromosomes, Mammalian; DNA Replication Timing; Down Syndrome; Female; Fetus; Fibroblasts; Gene Expression Regulation; Genome; Histones; Humans; Induced Pluripotent Stem Cells; Lysine; Male; Methylation; Mice; Transcriptome; Twins, Monozygotic | 2014 |
Transcriptional regulation of the albumin gene depends on the removal of histone methylation marks by the FAD-dependent monoamine oxidase lysine-specific demethylase 1 in HepG2 human hepatocarcinoma cells.
Topics: Biomarkers; Epigenetic Repression; Flavin-Adenine Dinucleotide; Glutathione; Glutathione Reductase; Hep G2 Cells; Hepatocytes; Histone Demethylases; Histones; Humans; Lysine; Methylation; Monoamine Oxidase; Osmolar Concentration; Promoter Regions, Genetic; Protein Processing, Post-Translational; Riboflavin; RNA, Messenger; Serum Albumin; Serum Albumin, Human; Transcriptional Activation | 2014 |
Gene-specific methylation control of H3K9 and H3K36 on neurotrophic BDNF versus astroglial GFAP genes by KDM4A/C regulates neural stem cell differentiation.
Topics: Animals; Astrocytes; Brain-Derived Neurotrophic Factor; Cell Differentiation; Cells, Cultured; Gene Expression Regulation; Glial Fibrillary Acidic Protein; Histones; Immunoblotting; Jumonji Domain-Containing Histone Demethylases; Lysine; Methylation; Mice; Microscopy, Fluorescence; Neural Stem Cells; Promoter Regions, Genetic; Rats; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; RNA Polymerase II | 2014 |
Triplication of a 21q22 region contributes to B cell transformation through HMGN1 overexpression and loss of histone H3 Lys27 trimethylation.
Topics: Animals; B-Lymphocytes; Bone Marrow Transplantation; Cell Proliferation; Chromosomes, Human, Pair 21; DNA Methylation; Female; Fusion Proteins, bcr-abl; Gene Duplication; Histones; HMGN1 Protein; Humans; Lysine; Male; Methylation; Mice; Mice, Inbred C57BL; Nucleosomes; Phenotype; Promoter Regions, Genetic | 2014 |
Uncovering the protein lysine and arginine methylation network in Arabidopsis chloroplasts.
Topics: Amino Acid Motifs; Arabidopsis; Arabidopsis Proteins; Arginine; Chloroplasts; Databases, Protein; Intracellular Space; Lysine; Mass Spectrometry; Methylation; Methyltransferases; Models, Molecular; Protein Conformation; Protein Transport; Recombinant Proteins | 2014 |
The histone methyltransferase ESET is required for the survival of spermatogonial stem/progenitor cells in mice.
Topics: Animals; Apoptosis; Cell Survival; Cells, Cultured; DNA Methylation; Electron Transport Complex IV; Fluorescent Antibody Technique; Histone-Lysine N-Methyltransferase; Histones; Lysine; Male; Methylation; Mice, Inbred C57BL; Models, Biological; Phenotype; RNA Interference; Spermatogonia; Stem Cell Transplantation; Stem Cells; Testis; Transduction, Genetic | 2014 |
Quiescence-induced LncRNAs trigger H4K20 trimethylation and transcriptional silencing.
Topics: Animals; Cell Proliferation; Chromatin; Gene Expression Regulation; Gene Silencing; Genes, Intracisternal A-Particle; Genes, rRNA; Genetic Loci; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Mice; NIH 3T3 Cells; RNA, Long Noncoding; Telomere | 2014 |
The relationship between lysine 4 on histone H3 methylation levels of alcohol tolerance genes and changes of ethanol tolerance in Saccharomyces cerevisiae.
Topics: Culture Media; Drug Tolerance; Epigenesis, Genetic; Ethanol; Gene Expression Profiling; Gene Expression Regulation, Fungal; Histones; Lysine; Methylation; Protein Processing, Post-Translational; Saccharomyces cerevisiae; Serial Passage | 2014 |
A role for WDR5 in integrating threonine 11 phosphorylation to lysine 4 methylation on histone H3 during androgen signaling and in prostate cancer.
Topics: Androgens; Cell Line, Tumor; Cell Proliferation; Chromatin; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; HeLa Cells; Histone-Lysine N-Methyltransferase; Histones; Humans; Intracellular Signaling Peptides and Proteins; Lysine; Male; Methylation; Myeloid-Lymphoid Leukemia Protein; Phosphorylation; Prostatic Neoplasms; Protein Kinase C; Receptors, Androgen; Signal Transduction; Threonine | 2014 |
Human UTY(KDM6C) is a male-specific Nϵ-methyl lysyl demethylase.
Topics: Amino Acid Sequence; Crystallography, X-Ray; Histones; Humans; Lysine; Male; Methylation; Minor Histocompatibility Antigens; Models, Molecular; Molecular Sequence Data; Nuclear Proteins; Protein Structure, Tertiary; Sequence Alignment; Species Specificity | 2014 |
A transgenic mouse model demonstrating the oncogenic role of mutations in the polycomb-group gene EZH2 in lymphomagenesis.
Topics: Animals; B-Lymphocytes; Blotting, Western; Bone Marrow Cells; Cell Proliferation; Cell Transformation, Neoplastic; Disease Models, Animal; Female; Flow Cytometry; Gene Expression Profiling; Histones; Humans; Kaplan-Meier Estimate; Lymphoma; Lymphoma, B-Cell; Lysine; Male; Methylation; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; Polycomb Repressive Complex 2; Proto-Oncogene Proteins c-myc; Spleen | 2014 |
Imprinting in rice: the role of DNA and histone methylation in modulating parent-of-origin specific expression and determining transcript start sites.
Topics: Genomic Imprinting; Histones; Lysine; Methylation; Oryza; Promoter Regions, Genetic | 2014 |
A region of euchromatin coincides with an extensive tandem repeat on the mouse (Mus musculus) inactive X chromosome.
Topics: Animals; Chromosomes, Mammalian; Euchromatin; Female; Heterochromatin; Histones; Humans; Lysine; Male; Methylation; Mice; Mice, Inbred C57BL; NIH 3T3 Cells; Short Interspersed Nucleotide Elements; Species Specificity; Tandem Repeat Sequences; X Chromosome; X Chromosome Inactivation; Y Chromosome | 2014 |
Multiplexed parallel reaction monitoring targeting histone modifications on the QExactive mass spectrometer.
Topics: Acetylation; Histones; Lysine; Mass Spectrometry; Methylation; Peptides; Propionates; Trypsin | 2014 |
Site-specific human histone H3 methylation stability: fast K4me3 turnover.
Topics: Chromatin; Gene Expression Regulation; HeLa Cells; Histones; Humans; Isotope Labeling; Lysine; Methylation; Protein Stability | 2014 |
Histone methyltransferase G9a and H3K9 dimethylation inhibit the self-renewal of glioma cancer stem cells.
Topics: AC133 Antigen; Antigens, CD; Azepines; Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Enzyme Inhibitors; Gene Expression Regulation, Neoplastic; Glioma; Glycoproteins; Histocompatibility Antigens; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Neoplastic Stem Cells; Peptides; Promoter Regions, Genetic; Quinazolines; Signal Transduction; SOXB1 Transcription Factors; Transfection | 2014 |
Histone lysine methyltransferase SDG8 is involved in brassinosteroid-regulated gene expression in Arabidopsis thaliana.
Topics: Arabidopsis; Arabidopsis Proteins; Brassinosteroids; DNA-Binding Proteins; Gene Expression Regulation, Plant; Gene Knockout Techniques; Genomics; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Mutation; Nuclear Proteins; Phenotype; Protein Transport; Signal Transduction; Transcription Factors | 2014 |
SMYD3 links lysine methylation of MAP3K2 to Ras-driven cancer.
Topics: Adenocarcinoma; Adenocarcinoma of Lung; Animals; Cell Line, Tumor; Cell Transformation, Neoplastic; Disease Models, Animal; Histone-Lysine N-Methyltransferase; Humans; Lung Neoplasms; Lysine; MAP Kinase Kinase Kinase 2; MAP Kinase Kinase Kinases; Methylation; Mice; Mitogen-Activated Protein Kinases; Oncogene Protein p21(ras); Pancreatic Neoplasms; Protein Phosphatase 2; Proto-Oncogene Proteins A-raf; Signal Transduction | 2014 |
Genome-wide quantitative analysis of histone H3 lysine 4 trimethylation in wild house mouse liver: environmental change causes epigenetic plasticity.
Topics: Animals; Animals, Wild; Epigenesis, Genetic; Female; Genomics; Histones; Liver; Lysine; Male; Methylation; Mice; Protein Stability | 2014 |
Chromatin organisation in duckweed interphase nuclei in relation to the nuclear DNA content.
Topics: Arabidopsis; Araceae; Chromatin; DNA, Plant; Epigenesis, Genetic; Euchromatin; Heterochromatin; Histones; Interphase; Lysine; Methylation; Phylogeny; Species Specificity | 2015 |
Lysine methylation is an endogenous post-translational modification of tau protein in human brain and a modulator of aggregation propensity.
Topics: Amino Acid Sequence; Humans; Lysine; Male; Methylation; Microtubules; Middle Aged; Phosphorylation; Protein Processing, Post-Translational; Protein Structure, Quaternary; Tandem Mass Spectrometry; tau Proteins; Tubulin | 2014 |
RLIM is dispensable for X-chromosome inactivation in the mouse embryonic epiblast.
Topics: Animals; Down-Regulation; Embryo Implantation; Embryo, Mammalian; Female; Germ Layers; Histones; In Situ Hybridization, Fluorescence; Lysine; Methylation; Mice; Mice, Knockout; RNA, Long Noncoding; Ubiquitin-Protein Ligases; X Chromosome Inactivation | 2014 |
Lysine-specific demethylase 1-mediated demethylation of histone H3 lysine 9 contributes to interleukin 1β-induced microsomal prostaglandin E synthase 1 expression in human osteoarthritic chondrocytes.
Topics: Adult; Aged; Aged, 80 and over; Blotting, Western; Cells, Cultured; Chondrocytes; Gene Expression; Histone Demethylases; Histones; Humans; Interleukin-1beta; Intramolecular Oxidoreductases; Lysine; Methylation; Middle Aged; Monoamine Oxidase Inhibitors; Osteoarthritis; Pargyline; Promoter Regions, Genetic; Prostaglandin-E Synthases; Protein Binding; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Tranylcypromine | 2014 |
EZH2 represses target genes through H3K27-dependent and H3K27-independent mechanisms in hepatocellular carcinoma.
Topics: Animals; Carcinoma, Hepatocellular; Cell Movement; Cell Proliferation; Enhancer of Zeste Homolog 2 Protein; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Histones; Humans; Liver Neoplasms; Lysine; Methylation; Mice, Nude; Polycomb Repressive Complex 2; Repressor Proteins; Signal Transduction; Transcription, Genetic; Tumor Suppressor Protein p53; Xenograft Model Antitumor Assays | 2014 |
Changes in histone H3 lysine 36 methylation in porcine oocytes and preimplantation embryos.
Topics: Animals; Blastocyst; Cells, Cultured; Cloning, Organism; Embryonic Development; Female; Fertilization in Vitro; Gene Expression Regulation, Developmental; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Nuclear Transfer Techniques; Oocytes; Parthenogenesis; Pregnancy; Protein Processing, Post-Translational; Swine | 2014 |
DNA double-strand breaks promote methylation of histone H3 on lysine 9 and transient formation of repressive chromatin.
Topics: Ataxia Telangiectasia Mutated Proteins; Chromatin; Chromatin Assembly and Disassembly; DNA Breaks, Double-Stranded; HEK293 Cells; HeLa Cells; Histone Acetyltransferases; Histones; Humans; Lysine; Lysine Acetyltransferase 5; Methylation; Methyltransferases; Phosphorylation; Protein Structure, Tertiary; Repressor Proteins; Tripartite Motif-Containing Protein 28 | 2014 |
The polycomb group protein EZH2 inhibits lung cancer cell growth by repressing the transcription factor Nrf2.
Topics: Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Cell Proliferation; Disease Progression; Enhancer of Zeste Homolog 2 Protein; Epigenesis, Genetic; Female; Histones; Humans; Lung Neoplasms; Lysine; Male; Methylation; Middle Aged; NF-E2-Related Factor 2; Polycomb Repressive Complex 2; Survival Analysis | 2014 |
One-pot native chemical ligation of peptide hydrazides enables total synthesis of modified histones.
Topics: Amino Acid Sequence; Chemistry, Organic; Histones; Hydrazines; Lysine; Mass Spectrometry; Methylation; Molecular Sequence Data; Peptides; Protein Multimerization; Protein Processing, Post-Translational | 2014 |
The PHD1 finger of KDM5B recognizes unmodified H3K4 during the demethylation of histone H3K4me2/3 by KDM5B.
Topics: Binding Sites; Crystallography, X-Ray; Gene Expression Regulation; HEK293 Cells; Histones; Humans; Jumonji Domain-Containing Histone Demethylases; Lysine; Magnetic Resonance Spectroscopy; Methylation; Microscopy, Fluorescence; Models, Molecular; Mutation; Nuclear Proteins; Peptides; Protein Binding; Protein Structure, Tertiary; Repressor Proteins | 2014 |
[Effects of ceruloplasmin/PTEN on histone modifications induced by silica].
Topics: Acetylation; Ceruloplasmin; Fibroblasts; Histones; Humans; Lysine; Methylation; Oxidation-Reduction; Proteins; PTEN Phosphohydrolase; Silicon Dioxide | 2014 |
A scintillation proximity assay for histone demethylases.
Topics: Enzyme Assays; Enzyme Inhibitors; Histone Demethylases; Humans; Jumonji Domain-Containing Histone Demethylases; Kinetics; Lysine; Methylation; Protein Binding; Protein Methyltransferases | 2014 |
Human METTL20 methylates lysine residues adjacent to the recognition loop of the electron transfer flavoprotein in mitochondria.
Topics: Amino Acid Sequence; Base Sequence; Cell Line, Tumor; Chromatography, Affinity; DNA Primers; Electron Transport; Flavoproteins; Humans; Lysine; Mass Spectrometry; Methylation; Methyltransferases; Mitochondria; Molecular Sequence Data | 2014 |
Lysine methylation-dependent binding of 53BP1 to the pRb tumor suppressor.
Topics: Animals; Binding Sites; Cell Line, Tumor; Cellular Senescence; Chromatin; Chromosomal Proteins, Non-Histone; DNA Repair; DNA-Binding Proteins; Humans; Intracellular Signaling Peptides and Proteins; Lysine; Methylation; Mice; Models, Molecular; Peptides; Protein Binding; Protein Structure, Tertiary; Retinoblastoma Protein; Tumor Suppressor p53-Binding Protein 1 | 2014 |
Changes in histone methylation and acetylation during microspore reprogramming to embryogenesis occur concomitantly with Bn HKMT and Bn HAT expression and are associated with cell totipotency, proliferation, and differentiation in Brassica napus.
Topics: Acetylation; Brassica napus; Cell Differentiation; Cell Proliferation; Haploidy; Histone Acetyltransferases; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Pollen; Seeds; Totipotent Stem Cells | 2014 |
EZH2-induced H3K27me3 is associated with epigenetic repression of the ARHI tumor-suppressor gene in ovarian cancer.
Topics: Adenosine; Carcinogenesis; Carcinoma, Ovarian Epithelial; Cell Line, Tumor; Cell Proliferation; Enhancer of Zeste Homolog 2 Protein; Epigenetic Repression; Female; Gene Knockdown Techniques; Histones; Humans; Lysine; Methylation; Neoplasms, Glandular and Epithelial; Ovarian Neoplasms; Polycomb Repressive Complex 2; rho GTP-Binding Proteins; RNA, Small Interfering; Survival Analysis; Tumor Suppressor Proteins | 2015 |
Elongation factor methyltransferase 3--a novel eukaryotic lysine methyltransferase.
Topics: Amino Acid Sequence; Gene Knockout Techniques; Genes, Fungal; Humans; Lysine; Methylation; Methyltransferases; Models, Molecular; Molecular Sequence Data; Peptide Elongation Factor 2; Peptide Fragments; Protein Conformation; Recombinant Proteins; Ribosome Subunits, Small, Eukaryotic; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sequence Homology, Amino Acid; Structural Homology, Protein; Substrate Specificity | 2014 |
Histone h4 modification during mouse spermatogenesis.
Topics: Acetylation; Animals; Arginine; Histones; Immunohistochemistry; Lysine; Male; Meiosis; Methylation; Mice; Mice, Inbred C57BL; Spermatogenesis | 2014 |
Matrix softness regulates plasticity of tumour-repopulating cells via H3K9 demethylation and Sox2 expression.
Topics: Animals; Biosensing Techniques; Cell Line, Tumor; Cell Proliferation; Disease Progression; DNA Methylation; Female; Fibrin; Fluorescence Resonance Energy Transfer; Gene Silencing; Histone-Lysine N-Methyltransferase; Histones; Integrin beta1; Lysine; Melanoma; Melanoma, Experimental; Methylation; Mice; Mice, Inbred C57BL; Neoplasm Metastasis; Neoplasm Transplantation; Neoplastic Stem Cells; Promoter Regions, Genetic; RNA, Small Interfering; Skin Neoplasms; SOXB1 Transcription Factors; Time Factors | 2014 |
Jarid2 is induced by TCR signalling and controls iNKT cell maturation.
Topics: Animals; Antigens, CD; Antigens, Differentiation, T-Lymphocyte; Bone Marrow Cells; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cell Differentiation; Cell Separation; Female; Flow Cytometry; Histones; Interleukin-4; Killer Cells, Natural; Kruppel-Like Transcription Factors; Lectins, C-Type; Lysine; Male; Methylation; Mice; Mice, Inbred C57BL; Mice, Transgenic; MicroRNAs; Polycomb Repressive Complex 2; Promoter Regions, Genetic; Promyelocytic Leukemia Zinc Finger Protein; Receptors, Antigen, T-Cell; Signal Transduction; Thymus Gland; Up-Regulation; Zinc Fingers | 2014 |
The gene silencing transcription factor REST represses miR-132 expression in hippocampal neurons destined to die.
Topics: Animals; Blotting, Western; CA1 Region, Hippocampal; Cell Death; Gene Expression Regulation; HEK293 Cells; Histones; Humans; Ischemia; Lysine; Male; Methylation; MicroRNAs; Neurons; Primary Cell Culture; Promoter Regions, Genetic; Rats, Sprague-Dawley; Repressor Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference | 2014 |
Transdifferentiation. Sequential histone-modifying activities determine the robustness of transdifferentiation.
Topics: Amino Acid Sequence; Animals; Animals, Genetically Modified; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Cell Dedifferentiation; Cell Nucleus; Cell Transdifferentiation; Digestive System; Histone Demethylases; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Models, Biological; Molecular Sequence Data; Motor Neurons; Transcription Factors | 2014 |
Inhibition of H3K4me2 Demethylation Protects Auditory Hair Cells from Neomycin-Induced Apoptosis.
Topics: Aminoglycosides; Animals; Apoptosis; Benzamidines; Caspase 3; Cyclopropanes; Cytoprotection; Disease Models, Animal; Hair Cells, Auditory; Histone Demethylases; Histones; Lysine; Methylation; Mice, Inbred C57BL; Neomycin; Organ of Corti; Phenyl Ethers; Piperazines | 2015 |
Contrasting roles of histone 3 lysine 27 demethylases in acute lymphoblastic leukaemia.
Topics: Animals; Benzazepines; Epigenesis, Genetic; Histone Demethylases; Histones; Jumonji Domain-Containing Histone Demethylases; Lysine; Methylation; Mice; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Pyrimidines; Tumor Suppressor Proteins | 2014 |
Polycomb protein EED is required for silencing of pluripotency genes upon ESC differentiation.
Topics: Animals; Blotting, Western; Cell Differentiation; Cell Line; Cells, Cultured; Embryoid Bodies; Embryonic Stem Cells; Gene Expression Profiling; Histones; Homeodomain Proteins; Lysine; Methylation; Mice, Knockout; Microscopy, Fluorescence; Nanog Homeobox Protein; Octamer Transcription Factor-3; Polycomb Repressive Complex 2; Promoter Regions, Genetic; Protein Binding; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; SOXB1 Transcription Factors | 2015 |
Traceless semisynthesis of a set of histone 3 species bearing specific lysine methylation marks.
Topics: Amino Acid Sequence; HeLa Cells; Histones; Humans; Lysine; Methylation; Molecular Sequence Data; Nucleosomes; Protein Binding; Protein Processing, Post-Translational | 2014 |
Histone H3 lysine-to-methionine mutants as a paradigm to study chromatin signaling.
Topics: Amino Acid Substitution; Animals; Chromatin; Disease Models, Animal; Drosophila melanogaster; Drosophila Proteins; Gene Silencing; Glioma; Heterochromatin; Histone-Lysine N-Methyltransferase; Histones; Jumonji Domain-Containing Histone Demethylases; Lysine; Methionine; Methylation; Mutation; Signal Transduction | 2014 |
Acetyltransferase p300/CBP associated Factor (PCAF) regulates crosstalk-dependent acetylation of histone H3 by distal site recognition.
Topics: Acetylation; Arginine; Binding Sites; Epigenesis, Genetic; Escherichia coli; Histones; Humans; Kinetics; Lysine; Methylation; Models, Molecular; Nucleosomes; p300-CBP Transcription Factors; Peptide Library; Plasmids; Protein Processing, Post-Translational; Recombinant Proteins; Substrate Specificity | 2015 |
PHD finger protein 2 (PHF2) represses ribosomal RNA gene transcription by antagonizing PHF finger protein 8 (PHF8) and recruiting methyltransferase SUV39H1.
Topics: Cell Nucleolus; Genes, rRNA; HEK293 Cells; HeLa Cells; Histone Demethylases; Histones; Homeodomain Proteins; Humans; Kruppel-Like Factor 4; Lysine; Methylation; Methyltransferases; Models, Biological; Promoter Regions, Genetic; Protein Binding; Protein Structure, Tertiary; Protein Transport; Repressor Proteins; Transcription Factors; Transcription, Genetic | 2014 |
Developmental enhancers are marked independently of zygotic Nodal signals in Xenopus.
Topics: Acylation; Animals; Base Sequence; Benzamides; Blastula; Dioxoles; Enhancer Elements, Genetic; Gastrula; Gene Expression Regulation, Developmental; Histones; Lysine; Methylation; Molecular Sequence Data; Nodal Protein; Oligonucleotide Array Sequence Analysis; Sequence Homology, Nucleic Acid; Signal Transduction; Smad2 Protein; Smad3 Protein; Time Factors; Xenopus; Xenopus Proteins; Zygote | 2014 |
Association of H3K9me3 and H3K27me3 repressive histone marks with breast cancer subtypes in the Nurses' Health Study.
Topics: Adult; Breast Neoplasms; Epidemiologic Studies; Estrogen Receptor alpha; Female; Histones; Humans; Life Style; Lysine; Methylation; Middle Aged; Multivariate Analysis; Receptor, ErbB-2; Receptors, Progesterone; Reproductive History; Risk Factors; United States | 2014 |
Resveratrol affects histone 3 lysine 27 methylation of vessels and blood biomarkers in DOCA salt-induced hypertension.
Topics: Animals; Antioxidants; Arginine; Biomarkers; Blood Pressure; Blood Vessels; Desoxycorticosterone Acetate; Endothelium, Vascular; Fluorescent Antibody Technique; Histones; Hydrogen Sulfide; Hypertension; Lysine; Male; Methylation; Nitrites; Rats, Wistar; Renal Artery; Resveratrol; Stilbenes; Systole; Vasodilation | 2015 |
Molecular dynamics for computational proteomics of methylated histone H3.
Topics: Animals; Binding Sites; Energy Transfer; Histones; Humans; Lysine; Methylation; Molecular Dynamics Simulation; Protein Binding; Protein Interaction Mapping; Protein Processing, Post-Translational; Protein Structure, Tertiary; Proteomics; Reproducibility of Results; Transcription Factors | 2015 |
A natural antisense transcript regulates acetylcholinesterase gene expression via epigenetic modification in Hepatocellular Carcinoma.
Topics: Acetylcholinesterase; Antineoplastic Agents; Apoptosis; Blotting, Western; Carcinoma, Hepatocellular; Cell Line; Cell Line, Tumor; Cisplatin; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Hep G2 Cells; Histones; Humans; Liver Neoplasms; Lysine; Methylation; Mitomycin; Poly(ADP-ribose) Polymerases; Promoter Regions, Genetic; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; RNA, Antisense | 2014 |
Epigenetic dysregulation by nickel through repressive chromatin domain disruption.
Topics: Acetylation; Amino Acid Sequence; Binding Sites; Blotting, Western; Bronchi; CCCTC-Binding Factor; Cell Line; Chromatin; Epigenesis, Genetic; Epithelial Cells; Gene Expression Profiling; Genome, Human; Histones; Humans; Lysine; Methylation; Nickel; Oligonucleotide Array Sequence Analysis; Promoter Regions, Genetic; Protein Binding; Repressor Proteins; RNA Interference | 2014 |
Regulation of S-adenosylhomocysteine hydrolase by lysine acetylation.
Topics: Acetylation; Adenosylhomocysteinase; Amino Acid Sequence; Catalysis; Crystallography, X-Ray; Humans; Hydrogen Bonding; Lysine; Methylation; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; NAD; Plasmids; Protein Binding; Protein Processing, Post-Translational; Protein Structure, Tertiary; Recombinant Proteins; Sequence Homology, Amino Acid; Structure-Activity Relationship | 2014 |
Yeast histone H3 lysine 4 demethylase Jhd2 regulates mitotic rDNA condensation.
Topics: Adenosine Triphosphatases; DNA-Binding Proteins; DNA, Ribosomal; Gene Silencing; Histones; Jumonji Domain-Containing Histone Demethylases; Lysine; Methylation; Mitosis; Multiprotein Complexes; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins | 2014 |
Polycomb- and REST-associated histone deacetylases are independent pathways toward a mature neuronal phenotype.
Topics: Animals; Cell Differentiation; Chromatin; Embryonic Stem Cells; Gene Expression Regulation; Histone Deacetylases; Histones; Lysine; Methylation; Mice; Neurons; Phenotype; Polycomb Repressive Complex 2; Promoter Regions, Genetic; Repressor Proteins | 2014 |
A687V EZH2 is a driver of histone H3 lysine 27 (H3K27) hypertrimethylation.
Topics: Amino Acid Sequence; Amino Acid Substitution; Binding Sites; Cell Line, Tumor; Cluster Analysis; Enhancer of Zeste Homolog 2 Protein; Gene Expression; Gene Expression Profiling; Gene Silencing; Heterozygote; Histones; Humans; Lysine; Methylation; Models, Molecular; Molecular Sequence Data; Mutation; Polycomb Repressive Complex 2; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Protein Conformation; Sequence Alignment; Substrate Specificity; Transcriptional Activation | 2014 |
Expression of histone H3 lysine 4 methylation and its demethylases in the developing mouse testis.
Topics: Animals; Blotting, Western; Gene Expression Regulation, Enzymologic; Histone Demethylases; Histones; Immunohistochemistry; Lysine; Male; Methylation; Mice; Real-Time Polymerase Chain Reaction; RNA, Messenger; Testis | 2014 |
Chromatin-dependent repression of the Arabidopsis floral integrator genes involves plant specific PHD-containing proteins.
Topics: Acetylation; Amino Acid Sequence; Arabidopsis; Arabidopsis Proteins; Chromatin; Flowers; Gene Expression Regulation, Developmental; Gene Expression Regulation, Plant; Histone Deacetylases; Histones; Homeodomain Proteins; Lysine; MADS Domain Proteins; Methylation; Molecular Sequence Data; Mutation; Nuclear Proteins; Photoperiod; Protein Binding; Reverse Transcriptase Polymerase Chain Reaction; Sequence Homology, Amino Acid; Time Factors | 2014 |
Application of histone modification-specific interaction domains as an alternative to antibodies.
Topics: Amino Acid Sequence; Antibodies; Binding Sites; Blotting, Western; Chromatin Immunoprecipitation; DNA (Cytosine-5-)-Methyltransferases; DNA Methyltransferase 3A; HEK293 Cells; Histones; Humans; Lysine; Methylation; Peptides; Polycomb Repressive Complex 1; Protein Array Analysis; Protein Binding; Protein Interaction Mapping; Protein Processing, Post-Translational; Reproducibility of Results | 2014 |
NuA4 links methylation of histone H3 lysines 4 and 36 to acetylation of histones H4 and H3.
Topics: Acetylation; Blotting, Western; Histone Acetyltransferases; Histone Deacetylases; Histones; Lysine; Methylation; Mutation; Nucleosomes; Protein Binding; Protein Subunits; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Trans-Activators | 2014 |
Mixed lineage leukaemia histone methylases 1 collaborate with ERα to regulate HOXA10 expression in AML.
Topics: Acute Disease; Apoptosis; Blotting, Western; Cell Line, Tumor; Estradiol; Estrogen Receptor alpha; Estrogen Receptor beta; Estrogens; Gene Expression Regulation, Leukemic; Gene Knockdown Techniques; Histone-Lysine N-Methyltransferase; Histones; HL-60 Cells; Homeobox A10 Proteins; Homeodomain Proteins; Humans; Leukemia, Myeloid; Lysine; Methylation; Myeloid-Lymphoid Leukemia Protein; Promoter Regions, Genetic; Protein Binding; Response Elements; Reverse Transcriptase Polymerase Chain Reaction | 2014 |
A nonpyrrolysine member of the widely distributed trimethylamine methyltransferase family is a glycine betaine methyltransferase.
Topics: Betaine; Chromatography, Thin Layer; Desulfitobacterium; Genes, Bacterial; Glycine N-Methyltransferase; Humans; Lysine; Methylamines; Methylation; Phylogeny; Real-Time Polymerase Chain Reaction | 2014 |
High resolution is not a strict requirement for characterization and quantification of histone post-translational modifications.
Topics: Acetylation; Amino Acid Sequence; Chromatography, Liquid; HeLa Cells; Histones; Humans; Lysine; Mass Spectrometry; Methylation; Peptides; Protein Processing, Post-Translational; Proteomics; Reproducibility of Results; Tandem Mass Spectrometry | 2014 |
Role of choline and glycine betaine in the formation of N,N-dimethylpiperidinium (mepiquat) under Maillard reaction conditions.
Topics: Alkaloids; Betaine; Carbon Radioisotopes; Choline; Chromatography, High Pressure Liquid; Deuterium; Hot Temperature; Kinetics; Lysine; Maillard Reaction; Methylation; Models, Chemical; Molecular Structure; Molecular Weight; Piperidines; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2014 |
Knockdown of protein tyrosine phosphatase receptor U inhibits growth and motility of gastric cancer cells.
Topics: beta Catenin; Cell Adhesion; Cell Line, Tumor; Cell Movement; Cell Proliferation; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Histones; Humans; Lysine; Methylation; Neoplasm Invasiveness; Phosphorylation; Receptor-Like Protein Tyrosine Phosphatases, Class 2; RNA Interference; Signal Transduction; Stomach Neoplasms; Time Factors; Transcription, Genetic; Transfection; Tyrosine | 2014 |
Regulation of Wnt signaling target gene expression by the histone methyltransferase DOT1L.
Topics: Adenosine; Cell Line, Tumor; Enzyme Inhibitors; Gene Expression; HEK293 Cells; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Methyltransferases; Phenylurea Compounds; Wnt Signaling Pathway | 2015 |
Small ubiquitin-like modifier (SUMO)-mediated repression of the Xenopus Oocyte 5 S rRNA genes.
Topics: Animals; Blotting, Western; Cell Nucleus; Embryo, Nonmammalian; Gene Expression Regulation, Developmental; Histones; Immunohistochemistry; Lysine; Methylation; Microscopy, Confocal; Oocytes; Protein Binding; RNA, Ribosomal, 5S; Sumoylation; Transcription Factor TFIIIA; Two-Hybrid System Techniques; Xenopus laevis; Xenopus Proteins | 2014 |
Bivalent histone modifications during tooth development.
Topics: Animals; Cell Differentiation; Dental Papilla; DNA-Binding Proteins; Embryo, Mammalian; Enamel Organ; Enhancer of Zeste Homolog 2 Protein; Epigenesis, Genetic; Gene Expression Regulation, Developmental; Histone-Lysine N-Methyltransferase; Histones; Jumonji Domain-Containing Histone Demethylases; Lysine; Methylation; Mice; Mice, Inbred BALB C; Odontogenesis; Polycomb Repressive Complex 2; Protein Processing, Post-Translational; Tooth Germ | 2014 |
dRYBP counteracts chromatin-dependent activation and repression of transcription.
Topics: Animals; Blotting, Western; Cell Line; Chromatin; Drosophila melanogaster; Drosophila Proteins; Epistasis, Genetic; Gene Expression Regulation; Histones; Lysine; Methylation; Models, Genetic; Mutation; Polycomb Repressive Complex 1; Protein Binding; Repressor Proteins; RNA Interference; Ubiquitin; Ubiquitin-Protein Ligases; Ubiquitinated Proteins | 2014 |
Human METTL20 is a mitochondrial lysine methyltransferase that targets the β subunit of electron transfer flavoprotein (ETFβ) and modulates its activity.
Topics: Acyl-CoA Dehydrogenases; Amino Acid Sequence; Electron-Transferring Flavoproteins; Escherichia coli; Gene Expression; Glutaryl-CoA Dehydrogenase; HEK293 Cells; HeLa Cells; Humans; Lysine; Methylation; Methyltransferases; Mitochondria; Mitochondrial Proteins; Models, Molecular; Molecular Sequence Data; Protein Processing, Post-Translational; Protein Structure, Secondary; Protein Structure, Tertiary; Protein Subunits; Recombinant Proteins; S-Adenosylmethionine; Sequence Alignment | 2015 |
FMR1 epigenetic silencing commonly occurs in undifferentiated fragile X-affected embryonic stem cells.
Topics: 5' Untranslated Regions; Blotting, Western; Cell Line; DNA Methylation; Embryonic Stem Cells; Epigenesis, Genetic; Fragile X Mental Retardation Protein; Fragile X Syndrome; Gene Expression; Gene Silencing; Histones; Humans; Lysine; Methylation; Octamer Transcription Factor-3; Reverse Transcriptase Polymerase Chain Reaction; Sequence Analysis, DNA; SOXB1 Transcription Factors; Trinucleotide Repeat Expansion; X Chromosome Inactivation | 2014 |
Quantitative ChIP-Seq normalization reveals global modulation of the epigenome.
Topics: Animals; Benzimidazoles; Chromatin Immunoprecipitation; Drosophila melanogaster; Epigenesis, Genetic; High-Throughput Nucleotide Sequencing; Histones; Humans; Jurkat Cells; Lysine; Methylation; Reference Standards | 2014 |
Contributions of pocket depth and electrostatic interactions to affinity and selectivity of receptors for methylated lysine in water.
Topics: Combinatorial Chemistry Techniques; Lysine; Methylation; Models, Molecular; Molecular Structure; Static Electricity; Water | 2015 |
Activity and specificity of the human SUV39H2 protein lysine methyltransferase.
Topics: Amino Acid Sequence; Circular Dichroism; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Mutant Proteins; Phosphorylation; Protein Conformation; Substrate Specificity | 2015 |
Asymmetric histone 3 methylation pattern between paternal and maternal pronuclei in equine zygotes.
Topics: Animals; Fathers; Female; Fertilization; Histones; Horses; Lysine; Male; Methylation; Mothers; Zygote | 2015 |
Fine-tuning of histone H3 Lys4 methylation during pseudohyphal differentiation by the CDK submodule of RNA polymerase II.
Topics: Culture Media; Cyclin-Dependent Kinases; Fungal Proteins; Gene Expression Regulation, Fungal; Histones; Hyphae; Lysine; Methylation; Mutation; Phenotype; Promoter Regions, Genetic; RNA Polymerase II; Transcription Factors; Transcription, Genetic; Yeasts | 2015 |
The visualization of large organized chromatin domains enriched in the H3K9me2 mark within a single chromosome in a single cell.
Topics: Chromatin; Chromosomes, Human, Pair 11; DNA Probes; Genetic Techniques; HCT116 Cells; Histones; Humans; Image Processing, Computer-Assisted; Lysine; Methylation; Microscopy, Confocal; Single-Cell Analysis | 2014 |
Critical role of lysine 134 methylation on histone H2AX for γ-H2AX production and DNA repair.
Topics: Animals; Cell Separation; Chlorocebus aethiops; Chromatin; COS Cells; DNA Breaks, Double-Stranded; DNA Damage; DNA Repair; Fibroblasts; Flow Cytometry; Gamma Rays; Gene Expression Regulation; Genes, Dominant; HeLa Cells; Histones; Humans; Immunohistochemistry; Lung Neoplasms; Lysine; Methylation; Mice; Mutation; Phosphorylation; RNA, Small Interfering; Tissue Array Analysis | 2014 |
Degron protease blockade sensor to image epigenetic histone protein methylation in cells and living animals.
Topics: Animals; Biosensing Techniques; Cell Line, Tumor; Drug Evaluation, Preclinical; Epigenesis, Genetic; Histone-Lysine N-Methyltransferase; Histones; Humans; Leucine; Lysine; Methylation; Mice; Optical Imaging; Pluripotent Stem Cells; Protease Inhibitors; Recombinant Fusion Proteins; RNA, Small Interfering | 2015 |
Specificity analysis of protein lysine methyltransferases using SPOT peptide arrays.
Topics: Amino Acid Sequence; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Oligopeptides; Protein Array Analysis; Substrate Specificity | 2014 |
In vitro histone lysine methylation by NSD1, NSD2/MMSET/WHSC1 and NSD3/WHSC1L.
Topics: Catalytic Domain; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Lysine; Methylation; Models, Molecular; Nuclear Proteins; Protein Structure, Secondary; Repressor Proteins | 2014 |
A chemical proteomics approach for global analysis of lysine monomethylome profiling.
Topics: Amino Acid Sequence; Antibodies; Cell Line; Computational Biology; Humans; Isotope Labeling; Lysine; Methylation; Molecular Sequence Data; Peptides; Proteome; Proteomics; Reproducibility of Results | 2015 |
Genetically encoded molecular biosensors to image histone methylation in living animals.
Topics: Acetylation; Animals; Biosensing Techniques; Enzyme Inhibitors; HEK293 Cells; HeLa Cells; Hep G2 Cells; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; Image Processing, Computer-Assisted; Lysine; Methylation; Protein Processing, Post-Translational | 2015 |
Epigenetic silencing of microRNA-218 via EZH2-mediated H3K27 trimethylation is involved in malignant transformation of HBE cells induced by cigarette smoke extract.
Topics: Bronchi; Cell Line; Cell Transformation, Neoplastic; Enhancer of Zeste Homolog 2 Protein; Epigenesis, Genetic; Epithelial Cells; Gene Expression Regulation, Neoplastic; Histones; Humans; Lung Neoplasms; Lysine; Methylation; MicroRNAs; Mitogen-Activated Protein Kinase 7; Smoking | 2016 |
Mitotic accumulation of dimethylated lysine 79 of histone H3 is important for maintaining genome integrity during mitosis in human cells.
Topics: Cell Cycle; Cell Line; Cytoplasm; Gene Expression; Gene Silencing; Genome, Human; Genomic Instability; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Methyltransferases; Mitosis; Protein Transport; RNA Interference; RNA, Small Interfering; Ubiquitin-Protein Ligases | 2015 |
Complex coding of endogenous siRNA, transcriptional silencing and H3K9 methylation on native targets of germline nuclear RNAi in C. elegans.
Topics: Animals; Argonaute Proteins; Caenorhabditis elegans; Chromatin; Gene Expression Profiling; Histones; Lysine; Methylation; Retroelements; RNA Interference; RNA Polymerase II; RNA, Small Interfering; Transcription, Genetic | 2014 |
Persistence of furan-induced epigenetic aberrations in the livers of F344 rats.
Topics: Acetylation; Animals; DNA Damage; Epigenesis, Genetic; Furans; Gene Expression Profiling; Histones; Liver; Lysine; Male; Methylation; Rats; Rats, Inbred F344 | 2015 |
Terminal epidermal differentiation is regulated by the interaction of Fra-2/AP-1 with Ezh2 and ERK1/2.
Topics: Animals; Cell Differentiation; Cells, Cultured; Embryo, Mammalian; Enhancer of Zeste Homolog 2 Protein; Fos-Related Antigen-2; Gene Expression Regulation, Developmental; Keratinocytes; Lysine; Methylation; Mice; Mitogen-Activated Protein Kinase 1; Phosphorylation; Polycomb Repressive Complex 2; Transcription Factor AP-1 | 2015 |
Directed targeting of chromatin to the nuclear lamina is mediated by chromatin state and A-type lamins.
Topics: Active Transport, Cell Nucleus; Animals; Binding Sites; Chromatin; Chromatin Assembly and Disassembly; DNA-Binding Proteins; Fibroblasts; Gene Expression Regulation; Histones; Lamin Type A; Lysine; Methylation; Mice; Mice, Inbred C57BL; Mice, Transgenic; Molecular Sequence Data; NIH 3T3 Cells; Nuclear Lamina; Nucleic Acid Conformation; Protein Conformation; RNA Interference; Time Factors; Transfection; YY1 Transcription Factor | 2015 |
The proximal J kappa germline-transcript promoter facilitates receptor editing through control of ordered recombination.
Topics: Animals; B-Lymphocytes; Cells, Cultured; Female; Flow Cytometry; Gene Expression; Germ Cells; Histones; Immunoglobulin Joining Region; Immunoglobulin kappa-Chains; Immunoglobulin Variable Region; Lysine; Male; Methylation; Mice, Inbred C57BL; Mice, Knockout; Promoter Regions, Genetic; Receptors, Antigen, B-Cell; Reverse Transcriptase Polymerase Chain Reaction; V(D)J Recombination | 2015 |
Biochemical reconstitution and phylogenetic comparison of human SET1 family core complexes involved in histone methylation.
Topics: Amino Acid Substitution; Crystallography, X-Ray; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Multiprotein Complexes; Myeloid-Lymphoid Leukemia Protein; Nuclear Proteins; Phylogeny; Protein Binding; Transcription Factors | 2015 |
Lysine demethylase KDM4A associates with translation machinery and regulates protein synthesis.
Topics: Aminopyridines; Drug Resistance; Humans; Hydrazones; Jumonji Domain-Containing Histone Demethylases; Lysine; Methylation; Peptide Chain Initiation, Translational; Peptide Initiation Factors; Protein Binding; Protein Biosynthesis; Protein Kinase Inhibitors; Ribosomal Proteins; TOR Serine-Threonine Kinases | 2015 |
Histone methylation patterns in astrocytes are influenced by age following ischemia.
Topics: Acetylation; Acetyltransferases; Aging; Animals; Astrocytes; Brain Ischemia; Cerebral Cortex; Female; Histones; Lysine; Methylation; Methyltransferases; Rats, Sprague-Dawley | 2015 |
A tight control of Rif1 by Oct4 and Smad3 is critical for mouse embryonic stem cell stability.
Topics: Animals; Cell Differentiation; Cell Movement; Cell Proliferation; DNA Repair; Embryonic Stem Cells; Gene Expression Profiling; Gene Expression Regulation, Developmental; Gene Knockdown Techniques; Histones; Lysine; Methylation; Mice; Models, Biological; Octamer Transcription Factor-3; Promoter Regions, Genetic; Protein Binding; RNA, Messenger; RNA, Small Interfering; Smad3 Protein; Telomere-Binding Proteins; Teratoma; Ultraviolet Rays | 2015 |
The requirement of histone modification by PRDM12 and Kdm4a for the development of pre-placodal ectoderm and neural crest in Xenopus.
Topics: Amino Acid Sequence; Animals; Animals, Genetically Modified; Blotting, Western; Carrier Proteins; Ectoderm; Embryo, Nonmammalian; Gene Expression Regulation, Developmental; Gene Knockdown Techniques; Histone Demethylases; Histones; In Situ Hybridization; Lysine; Methylation; Molecular Sequence Data; Nerve Tissue Proteins; Neural Crest; Promoter Regions, Genetic; Protein Binding; Reverse Transcriptase Polymerase Chain Reaction; Sequence Homology, Amino Acid; Xenopus laevis; Xenopus Proteins | 2015 |
Global and specific responses of the histone acetylome to systematic perturbation.
Topics: Acetylation; Animals; Cell Line; Drosophila melanogaster; Drosophila Proteins; Histone Acetyltransferases; Histone Deacetylases; Histones; Humans; Lysine; Mass Spectrometry; Methylation; Proteomics | 2015 |
The histone methyltransferase Smyd2 is a negative regulator of macrophage activation by suppressing interleukin 6 (IL-6) and tumor necrosis factor α (TNF-α) production.
Topics: Animals; Blotting, Western; Cell Differentiation; Cell Line; Cells, Cultured; Flow Cytometry; Gene Expression Regulation; Histone-Lysine N-Methyltransferase; Histones; Interleukin-6; Lysine; Macrophage Activation; Macrophages; MAP Kinase Signaling System; Methylation; Mice, Inbred C57BL; Mutation; NF-kappa B; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; T-Lymphocytes, Regulatory; Th17 Cells; Tumor Necrosis Factor-alpha | 2015 |
Conservation of complete trimethylation of lysine-43 in the rotor ring of c-subunits of metazoan adenosine triphosphate (ATP) synthases.
Topics: Amino Acid Sequence; Animals; Conserved Sequence; Humans; Invertebrates; Lysine; Methylation; Molecular Sequence Data; Molecular Weight; Peptides; Phylogeny; Protein Processing, Post-Translational; Protein Subunits; Proton-Translocating ATPases; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry | 2015 |
NF-κB-dependent and -independent epigenetic modulation using the novel anti-cancer agent DMAPT.
Topics: Animals; Apoptosis Regulatory Proteins; Bcl-2-Like Protein 11; Biomarkers, Tumor; Breast Neoplasms; Cell Line, Tumor; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Genome, Human; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; I-kappa B Proteins; Intracellular Signaling Peptides and Proteins; Lysine; Membrane Proteins; Methylation; Mice; NF-kappa B; NF-KappaB Inhibitor alpha; Nuclear Proteins; Prognosis; Protein Processing, Post-Translational; Proto-Oncogene Proteins; Sesquiterpenes; Transcription Factor RelA; Urinary Bladder Neoplasms | 2015 |
Jarid2 Methylation via the PRC2 Complex Regulates H3K27me3 Deposition during Cell Differentiation.
Topics: Animals; Cell Differentiation; Cell Line; Chromatin; Drosophila melanogaster; Drosophila Proteins; Embryonic Stem Cells; Enhancer of Zeste Homolog 2 Protein; Female; HEK293 Cells; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Mice, Knockout; Models, Genetic; Mutation; Polycomb Repressive Complex 2; RNA Interference | 2015 |
Lysine-specific demethylase 2 suppresses lipid influx and metabolism in hepatic cells.
Topics: Animals; Down-Regulation; Hep G2 Cells; Hepatocytes; Histone Demethylases; Histones; Humans; Lipid Metabolism; Lipids; Liver; Lysine; Male; Methylation; Mice, Inbred C57BL; Proto-Oncogene Proteins c-jun | 2015 |
13C NMR detects conformational change in the 100-kD membrane transporter ClC-ec1.
Topics: Antiporters; Carbon Radioisotopes; Carbon-13 Magnetic Resonance Spectroscopy; Chloride-Bicarbonate Antiporters; Crystallography, X-Ray; Cysteine; Escherichia coli; Escherichia coli Proteins; Lysine; Methionine; Methylation; Models, Molecular; Nuclear Magnetic Resonance, Biomolecular; Protein Conformation; Protein Structure, Tertiary | 2015 |
ROW1 maintains quiescent centre identity by confining WOX5 expression to specific cells.
Topics: Arabidopsis; Arabidopsis Proteins; Gene Expression Regulation, Plant; Genetic Complementation Test; Histones; Homeodomain Proteins; Lysine; Meristem; Methylation; Mutation; Phenotype; Plant Cells; Promoter Regions, Genetic; Protein Binding; Repressor Proteins; RNA Interference; RNA, Messenger | 2015 |
Small-molecule modulators of methyl-lysine binding for the CBX7 chromodomain.
Topics: Binding Sites; Cell Line, Tumor; Cyclin-Dependent Kinase Inhibitor p16; Fluorescein-5-isothiocyanate; Histones; Humans; Lysine; Methylation; Polycomb Repressive Complex 1; Protein Binding; Protein Structure, Tertiary; Small Molecule Libraries; Static Electricity; Suramin | 2015 |
Nanogrooved substrate promotes direct lineage reprogramming of fibroblasts to functional induced dopaminergic neurons.
Topics: Animals; Biomarkers; Cell Differentiation; Cell Lineage; Cell Shape; Cellular Reprogramming; Cytoskeleton; Dopaminergic Neurons; Embryo, Mammalian; Fibroblasts; Gene Expression Regulation; Histones; Lysine; Methylation; Mice; Nanoparticles; Phenotype; Proto-Oncogene Proteins c-met | 2015 |
Cadmium induces histone H3 lysine methylation by inhibiting histone demethylase activity.
Topics: Animals; Cadmium; Cattle; Cell Line; Enzyme Inhibitors; Histone Demethylases; Histones; Lysine; Methylation | 2015 |
DNA double strand break repair pathway choice: a chromatin based decision?
Topics: Chromatin; DNA Breaks, Double-Stranded; DNA Repair; Genomic Instability; Histones; Homologous Recombination; Lysine; Methylation; Models, Biological | 2015 |
DEFORMED FLORAL ORGAN1 (DFO1) regulates floral organ identity by epigenetically repressing the expression of OsMADS58 in rice (Oryza sativa).
Topics: Chromatin; Cloning, Molecular; Epigenesis, Genetic; Flowers; Gene Expression Regulation, Plant; Genes, Plant; Histones; Lysine; Methylation; Mutation; Nuclear Proteins; Organ Specificity; Organogenesis; Oryza; Phenotype; Plant Proteins; Polycomb-Group Proteins; Protein Binding; Real-Time Polymerase Chain Reaction; Repressor Proteins | 2015 |
Mass spectrometric quantification of histone post-translational modifications by a hybrid chemical labeling method.
Topics: Chromatography, Liquid; Gene Knockdown Techniques; HEK293 Cells; HeLa Cells; Histone Demethylases; Histones; Humans; Lysine; Mass Spectrometry; Methylation; Peptides; Propionates; Protein Processing, Post-Translational; Reference Standards; RNA, Small Interfering; Staining and Labeling; Trypsin | 2015 |
A specific LSD1/KDM1A isoform regulates neuronal differentiation through H3K9 demethylation.
Topics: Alternative Splicing; Cell Differentiation; Cell Movement; Gene Expression Regulation; Gene Knockdown Techniques; HeLa Cells; Histone Demethylases; Histones; Humans; Lysine; Membrane Proteins; Methylation; Microfilament Proteins; Neurons; Promoter Regions, Genetic; Protein Isoforms | 2015 |
Coupling of T cell receptor specificity to natural killer T cell development by bivalent histone H3 methylation.
Topics: Animals; CD4 Antigens; CD8-Positive T-Lymphocytes; Chromatin; Enhancer of Zeste Homolog 2 Protein; Histone Demethylases; Histones; Jumonji Domain-Containing Histone Demethylases; Kruppel-Like Transcription Factors; Lysine; Methylation; Mice, Inbred C57BL; Mice, Transgenic; Natural Killer T-Cells; Polycomb Repressive Complex 2; Promoter Regions, Genetic; Promyelocytic Leukemia Zinc Finger Protein; Receptors, Antigen, T-Cell; T-Cell Antigen Receptor Specificity | 2015 |
Histone lysine methyltransferase Ezh1 promotes TLR-triggered inflammatory cytokine production by suppressing Tollip.
Topics: Animals; Blotting, Western; Cells, Cultured; Cytokines; Dendritic Cells; Histones; Immunity, Innate; Inflammation Mediators; Intracellular Signaling Peptides and Proteins; Lipopolysaccharides; Lysine; Macrophages; Methylation; Mice, Inbred C57BL; Oligodeoxyribonucleotides; Poly I-C; Polycomb Repressive Complex 2; Promoter Regions, Genetic; Protein Binding; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Toll-Like Receptors; Transcriptome | 2015 |
Epigenetic remodeling in B-cell acute lymphoblastic leukemia occurs in two tracks and employs embryonic stem cell-like signatures.
Topics: Alcohol Oxidoreductases; B-Lymphocytes; Child; Co-Repressor Proteins; CpG Islands; DNA Methylation; Embryonic Stem Cells; Epigenomics; Gene Expression Profiling; Histones; Humans; Lysine; Methylation; Neoplasm Proteins; Nerve Tissue Proteins; Oligonucleotide Array Sequence Analysis; Polycomb Repressive Complex 2; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Precursor Cells, B-Lymphoid; Signal Transduction; Transcription Factors | 2015 |
DNA methylation and histone modification patterns during the late embryonic and early postnatal development of chickens.
Topics: Acetylation; Animals; Apoptosis; Avian Proteins; Caspase 3; Cell Proliferation; Chick Embryo; Chickens; DNA Methylation; Gene Expression; Histones; Jejunum; Liver; Lysine; Methylation; Pectoralis Muscles; Proliferating Cell Nuclear Antigen | 2015 |
A linear time algorithm for detecting long genomic regions enriched with a specific combination of epigenetic states.
Topics: Algorithms; Animals; Computational Biology; Epigenesis, Genetic; Epigenomics; Genomics; Histones; Humans; Internet; Lysine; Methylation; Oryzias; Reproducibility of Results; Software | 2015 |
H3K4me3 demethylation by the histone demethylase KDM5C/JARID1C promotes DNA replication origin firing.
Topics: Cell Cycle; Cell Cycle Proteins; Chromatin; DNA Replication; HeLa Cells; Histone Demethylases; Histones; Humans; Immunoblotting; Lysine; Methylation; Oxidoreductases, N-Demethylating; Proliferating Cell Nuclear Antigen; Protein Binding; Replication Origin; RNA Interference; Time Factors | 2015 |
KdmA, a histone H3 demethylase with bipartite function, differentially regulates primary and secondary metabolism in Aspergillus nidulans.
Topics: Aspergillus nidulans; Co-Repressor Proteins; Gene Expression Profiling; Gene Expression Regulation, Fungal; Genome, Fungal; Histone Demethylases; Histones; Light; Lysine; Mass Spectrometry; Methylation; Models, Molecular; Phenotype; Phylogeny; Secondary Metabolism; Sequence Deletion | 2015 |
Transcriptional activity of the islet β cell factor Pdx1 is augmented by lysine methylation catalyzed by the methyltransferase Set7/9.
Topics: Amino Acid Sequence; Animals; Cell Line, Tumor; HEK293 Cells; Histone-Lysine N-Methyltransferase; Homeodomain Proteins; Humans; Immunoblotting; Insulin-Secreting Cells; Lysine; Methylation; Mice; Mice, Inbred C57BL; Mice, Knockout; Molecular Sequence Data; NIH 3T3 Cells; Protein Binding; Reverse Transcriptase Polymerase Chain Reaction; Tandem Mass Spectrometry; Trans-Activators; Transcription, Genetic | 2015 |
Neighboring Genes Show Correlated Evolution in Gene Expression.
Topics: 5-Methylcytosine; Animals; Cerebellum; Chromosomes, Human, Pair 2; Computer Simulation; Cytosine; Evolution, Molecular; Female; Gene Expression Regulation; Genes; Histones; Humans; Lysine; Male; Methylation; Monte Carlo Method; Organ Specificity; Primates; Statistics, Nonparametric; Up-Regulation | 2015 |
Lysine methylation modulates the protein-protein interactions of yeast cytochrome C Cyc1p.
Topics: Blotting, Western; Cytochromes c; Escherichia coli; Lysine; Mass Spectrometry; Methylation; Protein Binding; Two-Hybrid System Techniques | 2015 |
The PHD-finger module of the Arabidopsis thaliana defense regulator EDM2 can recognize triply modified histone H3 peptides.
Topics: Amino Acid Sequence; Arabidopsis; Arabidopsis Proteins; Disease Resistance; Escherichia coli; Gene Expression Regulation, Plant; Histones; Lysine; Methylation; Peptides; Protein Binding; Protein Processing, Post-Translational; Transcription Factors; Transcription, Genetic; Zinc Fingers | 2014 |
The zinc finger proteins ZNF644 and WIZ regulate the G9a/GLP complex for gene repression.
Topics: Base Sequence; Binding Sites; Blotting, Western; Cell Line, Tumor; Chromatin; Gene Expression Profiling; Gene Expression Regulation; HEK293 Cells; Histocompatibility Antigens; Histone-Lysine N-Methyltransferase; Histones; Humans; Kruppel-Like Transcription Factors; Lysine; Methylation; Multiprotein Complexes; Oligonucleotide Array Sequence Analysis; Protein Binding; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Transcription Factors; Zinc Fingers | 2015 |
Overexpression of JMJD3 may contribute to demethylation of H3K27me3 in CD4+ T cells from patients with systemic sclerosis.
Topics: Adult; Blotting, Western; CD4-Positive T-Lymphocytes; Female; Gene Expression; Histones; Humans; Jumonji Domain-Containing Histone Demethylases; Lysine; Male; Methylation; Middle Aged; Reverse Transcriptase Polymerase Chain Reaction; Scleroderma, Systemic | 2015 |
The TALE transcription factor homothorax functions to assemble heterochromatin during Drosophila embryogenesis.
Topics: Animals; Base Sequence; Binding Sites; Cell Nucleolus; Deoxyribonuclease I; DNA Breaks; DNA, Ribosomal; DNA, Satellite; Drosophila melanogaster; Drosophila Proteins; Embryo, Nonmammalian; Embryonic Development; Female; Heterochromatin; Histones; Homeodomain Proteins; Lysine; Methylation; Molecular Sequence Data; Mutation; Nucleic Acid Conformation; Protein Binding; RNA, Ribosomal; Transcription Factors; Transcription, Genetic | 2015 |
H3K27me3 is an Epigenetic Mark of Relevance in Endometriosis.
Topics: Adolescent; Adult; Blotting, Western; Cell Line; Cell Proliferation; Endometriosis; Endometrium; Enhancer of Zeste Homolog 2 Protein; Epigenesis, Genetic; Epithelial Cells; Female; Histones; Humans; Immunohistochemistry; Lysine; Methylation; Middle Aged; Polycomb Repressive Complex 2; Progesterone; Protein Processing, Post-Translational; Tissue Array Analysis; Young Adult | 2015 |
Unrestricted modification search reveals lysine methylation as major modification induced by tissue formalin fixation and paraffin embedding.
Topics: Amino Acid Sequence; Chromatography, Liquid; Cluster Analysis; Fixatives; Formaldehyde; Frozen Sections; Humans; Kidney; Lysine; Methylation; Paraffin Embedding; Proteome; Proteomics; Reproducibility of Results; Tandem Mass Spectrometry; Tissue Fixation | 2015 |
Clustering of mammalian Hox genes with other H3K27me3 targets within an active nuclear domain.
Topics: Animals; Cells, Cultured; Chromosomes, Mammalian; Embryo, Mammalian; Embryonic Stem Cells; Female; Gene Expression Profiling; Gene Expression Regulation, Developmental; Histones; Homeodomain Proteins; Lamin Type B; Lysine; Male; Methylation; Mice; Models, Genetic; Multigene Family; Nuclear Proteins; Oligonucleotide Array Sequence Analysis; Polycomb-Group Proteins; Protein Binding | 2015 |
Epigenetics. Restricted epigenetic inheritance of H3K9 methylation.
Topics: Cell Cycle Proteins; Epigenesis, Genetic; Heterochromatin; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Methyltransferases; Mutation; Nuclear Proteins; Protein Processing, Post-Translational; Schizosaccharomyces; Schizosaccharomyces pombe Proteins | 2015 |
Trimethylation of Lys36 on H3 restricts gene expression change during aging and impacts life span.
Topics: Aging; Animals; Caenorhabditis elegans; Drosophila melanogaster; Gene Expression Regulation; Histones; Longevity; Lysine; Methylation | 2015 |
Release of human cytomegalovirus from latency by a KAP1/TRIM28 phosphorylation switch.
Topics: Antigens, CD34; Chromobox Protein Homolog 5; Chromosomal Proteins, Non-Histone; Cytomegalovirus; Genome, Viral; Hematopoietic Stem Cells; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Monocytes; NF-kappa B; Phosphorylation; Protein Methyltransferases; Repressor Proteins; TOR Serine-Threonine Kinases; Tripartite Motif-Containing Protein 28; Virus Latency; Virus Replication | 2015 |
MORF-RELATED GENE702, a Reader Protein of Trimethylated Histone H3 Lysine 4 and Histone H3 Lysine 36, Is Involved in Brassinosteroid-Regulated Growth and Flowering Time Control in Rice.
Topics: Brassinosteroids; Chromatin; Down-Regulation; Flowers; Gene Expression Regulation, Developmental; Gene Expression Regulation, Plant; Gene Knockdown Techniques; Genes, Reporter; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Oryza; Phenotype; Phylogeny; Plant Proteins; Protein Binding; Time Factors | 2015 |
The basal transcription complex component TAF3 transduces changes in nuclear phosphoinositides into transcriptional output.
Topics: Amino Acid Sequence; Animals; Cell Differentiation; Cell Line; Cell Nucleus; Electrophoresis, Polyacrylamide Gel; Gene Expression Profiling; Histones; Homeodomain Proteins; Lysine; Methylation; Mice; Minor Histocompatibility Antigens; Molecular Sequence Data; Mutation; Myoblasts; Oligonucleotide Array Sequence Analysis; Phosphatidylinositols; Phosphotransferases (Alcohol Group Acceptor); Protein Binding; RNA Interference; Sequence Homology, Amino Acid; TATA-Binding Protein Associated Factors; Transcription Factor TFIID; Transcription, Genetic; Zebrafish | 2015 |
Repression of hypoxia-inducible factor α signaling by Set7-mediated methylation.
Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Cell Hypoxia; Cell Line; Cells, Cultured; Gene Expression Regulation; Glucose; Histone-Lysine N-Methyltransferase; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Lysine; Methylation; Mice; Signal Transduction; Transcription, Genetic | 2015 |
Dysregulation of AKT Pathway by SMYD2-Mediated Lysine Methylation on PTEN.
Topics: Acetylation; Cell Line, Tumor; Genes, Tumor Suppressor; HEK293 Cells; HeLa Cells; Histone-Lysine N-Methyltransferase; Humans; Lysine; Methylation; Phosphatidylinositol 3-Kinases; Phosphorylation; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-akt; PTEN Phosphohydrolase | 2015 |
Paternal H3K4 methylation is required for minor zygotic gene activation and early mouse embryonic development.
Topics: Animals; Embryonic Development; Epigenesis, Genetic; Fathers; Female; Fertilization; Fertilization in Vitro; Histones; Lysine; Male; Methylation; Mice; Mutation; Pregnancy; Spermatozoa; Transcriptional Activation; Zygote | 2015 |
Immunolabelling of human metaphase chromosomes reveals the same banded distribution of histone H3 isoforms methylated at lysine 4 in primary lymphocytes and cultured cell lines.
Topics: Cell Line; Chromosome Banding; Chromosomes, Human; Histones; Humans; Lymphocytes; Lysine; Metaphase; Methylation; Protein Isoforms | 2015 |
ChREBP binding and histone modifications modulate hepatic expression of the Fasn gene in a metabolic syndrome rat model.
Topics: Acetylation; Animals; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Epigenesis, Genetic; Fatty Acid Synthases; Histone Code; Histones; Insulin; Insulin Resistance; Lipogenesis; Liver; Lysine; Male; Metabolic Syndrome; Methylation; Promoter Regions, Genetic; Protein Processing, Post-Translational; Rats; Rats, Inbred SHR; RNA, Messenger | 2015 |
Genome-wide mapping of histone H3 lysine 4 trimethylation in Eucalyptus grandis developing xylem.
Topics: Cell Wall; Chromatin Immunoprecipitation; Chromosome Mapping; Eucalyptus; Gene Expression Regulation, Plant; Genes, Plant; Genetic Association Studies; Genome, Plant; Histones; Lysine; Methylation; Promoter Regions, Genetic; Real-Time Polymerase Chain Reaction; Reproducibility of Results; Sequence Analysis, DNA; Wood; Xylem | 2015 |
Chromatin-Mediated Reversible Silencing of Sense-Antisense Gene Pairs in Embryonic Stem Cells Is Consolidated upon Differentiation.
Topics: Animals; Cell Differentiation; Cells, Cultured; Chromatin; CpG Islands; DNA Methylation; DNA, Antisense; Doxycycline; Embryonic Stem Cells; Flow Cytometry; Gene Expression; Gene Silencing; Green Fluorescent Proteins; Histones; Lysine; Methylation; Mice, 129 Strain; Mice, Transgenic; Models, Genetic; Promoter Regions, Genetic | 2015 |
Alternation of histone and DNA methylation in human atherosclerotic carotid plaques.
Topics: Aged; Blood Cells; Carotid Arteries; Carotid Artery Diseases; Disease Progression; DNA (Cytosine-5-)-Methyltransferase 1; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA-Binding Proteins; Enzyme Induction; Female; Histocompatibility Antigens; Histone-Lysine N-Methyltransferase; Humans; Inflammation; Leukocytes; Long Interspersed Nucleotide Elements; Lysine; Macrophages; Male; Methylation; Middle Aged; Mixed Function Oxygenases; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Neoplasm Proteins; Plaque, Atherosclerotic; Protein Processing, Post-Translational; Proto-Oncogene Proteins; Real-Time Polymerase Chain Reaction | 2015 |
SET7/9 Enzyme Regulates Cytokine-induced Expression of Inducible Nitric-oxide Synthase through Methylation of Lysine 4 at Histone 3 in the Islet β Cell.
Topics: Animals; Apoptosis; Histone-Lysine N-Methyltransferase; Histones; Insulin-Secreting Cells; Interferon-gamma; Interleukin-1; Interleukin-1beta; Islets of Langerhans; Lysine; Methylation; Mice; Mice, Knockout; Nitric Oxide Synthase Type II; Protein Methyltransferases; Tumor Necrosis Factor-alpha | 2015 |
Synthesis of histone proteins by CPE ligation using a recombinant peptide as the C-terminal building block.
Topics: Automation, Laboratory; Chromatography, High Pressure Liquid; Chromatography, Reverse-Phase; Combinatorial Chemistry Techniques; Cysteine; Dipeptides; Histones; Humans; Japan; Lysine; Methylation; Models, Molecular; Oligopeptides; Peptide Fragments; Protein Processing, Post-Translational; Recombinant Proteins; Solid-Phase Synthesis Techniques; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2015 |
Global quantification of heterochromatin-associated histone methylations in cell lines with differential sensitivity to ionizing radiation.
Topics: DNA Damage; Dose-Response Relationship, Radiation; HeLa Cells; Heterochromatin; Histones; Humans; Lysine; MCF-7 Cells; Methylation; Radiation Tolerance; Radiation, Ionizing; Tumor Suppressor Protein p53 | 2015 |
The Arabidopsis GAGA-Binding Factor BASIC PENTACYSTEINE6 Recruits the POLYCOMB-REPRESSIVE COMPLEX1 Component LIKE HETEROCHROMATIN PROTEIN1 to GAGA DNA Motifs.
Topics: Arabidopsis; Arabidopsis Proteins; Carrier Proteins; Chromosomal Proteins, Non-Histone; DNA-Binding Proteins; Gene Expression Regulation, Plant; Genetic Loci; Genetic Pleiotropy; Histones; Lysine; Methylation; Models, Biological; Mutation; Nuclear Proteins; Nucleotide Motifs; Polycomb-Group Proteins; Protein Binding; Protein Multimerization; Protein Structure, Tertiary | 2015 |
High-resolution profiling of histone h3 lysine 36 trimethylation in metastatic renal cell carcinoma.
Topics: Carcinoma, Renal Cell; Chromatin Immunoprecipitation; Cohort Studies; Histones; Humans; Kidney Neoplasms; Lysine; Methylation; Neoplasm Metastasis | 2016 |
Kisspeptin Induces Dynamic Chromatin Modifications to Control GnRH Gene Expression.
Topics: Acetylation; Animals; Cell Line; Chromatin; Enhancer Elements, Genetic; Gene Expression Regulation; Gonadotropin-Releasing Hormone; Histones; Kisspeptins; Lysine; Methylation; Mice; Models, Biological; Nucleic Acid Conformation; Phosphorylation; Phosphoserine; Response Elements; RNA Polymerase II; Transcription, Genetic | 2016 |
Genome-Wide H3K4me3 Analysis in Angus Cattle with Divergent Tenderness.
Topics: Animals; Cattle; Gene Expression Profiling; Genomics; Histones; Lysine; Male; Methylation; Molecular Sequence Annotation; Muscle, Skeletal; Promoter Regions, Genetic; Red Meat | 2015 |
Osmotic stress induces phosphorylation of histone H3 at threonine 3 in pericentromeric regions of Arabidopsis thaliana.
Topics: Arabidopsis; Arabidopsis Proteins; Centromere; Chromosomes, Plant; Gene Expression Regulation, Plant; Heterochromatin; Histones; Immunoblotting; Lysine; Methylation; Mutation; Osmotic Pressure; Phosphorylation; Plants, Genetically Modified; Protein Serine-Threonine Kinases; Reverse Transcriptase Polymerase Chain Reaction; Sodium Chloride; Threonine | 2015 |
The histone methyltransferase SETDB1 represses endogenous and exogenous retroviruses in B lymphocytes.
Topics: Animals; B-Lymphocytes; Blotting, Western; Bone Marrow Cells; Cells, Cultured; DNA Methylation; Endogenous Retroviruses; Epigenesis, Genetic; Flow Cytometry; Gene Expression Profiling; Histone-Lysine N-Methyltransferase; Histones; Host-Pathogen Interactions; Lysine; Methylation; Mice, Inbred C57BL; Mice, Inbred CBA; Mice, Knockout; Mice, Transgenic; Oligonucleotide Array Sequence Analysis; Precursor Cells, B-Lymphoid; Retroviridae; Reverse Transcriptase Polymerase Chain Reaction; Terminal Repeat Sequences; Virus Activation | 2015 |
BEND3 represses rDNA transcription by stabilizing a NoRC component via USP21 deubiquitinase.
Topics: Blotting, Western; Cell Line, Tumor; Cell Nucleolus; Chromosomal Proteins, Non-Histone; DNA, Ribosomal; Gene Expression Regulation, Neoplastic; Histones; Humans; Lysine; Methylation; Microscopy, Fluorescence; Promoter Regions, Genetic; Protein Binding; Repressor Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Sumoylation; Ubiquitin Thiolesterase | 2015 |
A new kinetochore component CENP-W interacts with the polycomb-group protein EZH2 to promote gene silencing.
Topics: Chromatin; Chromosomal Proteins, Non-Histone; Enhancer of Zeste Homolog 2 Protein; Gene Silencing; Genes, Reporter; HEK293 Cells; HeLa Cells; Histones; Humans; Kinetochores; Luciferases; Lysine; Methylation; Neoplasm Proteins; Plasmids; Polycomb Repressive Complex 2; Promoter Regions, Genetic; Protein Binding; Protein Stability; Signal Transduction; Transcription Factors; Transfection | 2015 |
Saccharomyces cerevisiae Eukaryotic Elongation Factor 1A (eEF1A) Is Methylated at Lys-390 by a METTL21-Like Methyltransferase.
Topics: Amino Acid Sequence; DNA Modification Methylases; Humans; Lysine; Methylation; Methyltransferases; Models, Molecular; Molecular Sequence Data; Organisms, Genetically Modified; Peptide Elongation Factor 1; Protein Processing, Post-Translational; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins | 2015 |
JMJ24 binds to RDR2 and is required for the basal level transcription of silenced loci in Arabidopsis.
Topics: Arabidopsis; Arabidopsis Proteins; DNA Methylation; Gene Expression Regulation, Plant; Gene Silencing; Jumonji Domain-Containing Histone Demethylases; Lysine; Methylation; Mutation; Nuclear Proteins; Phylogeny; Plants, Genetically Modified; RNA-Dependent RNA Polymerase; Schizosaccharomyces pombe Proteins; Terminal Repeat Sequences; Transcription, Genetic | 2015 |
Molecular Mechanisms Mediating the Adaptive Regulation of Intestinal Riboflavin Uptake Process.
Topics: Adaptation, Physiological; Cell Line; Cell Membrane; Dietary Supplements; Enterocytes; Gene Expression Regulation; Histones; Humans; Intestinal Mucosa; Lysine; Membrane Transport Proteins; Methylation; Promoter Regions, Genetic; Real-Time Polymerase Chain Reaction; Riboflavin; RNA, Messenger; Substrate Specificity; Transcription, Genetic | 2015 |
Histone H2B Monoubiquitination Mediated by HISTONE MONOUBIQUITINATION1 and HISTONE MONOUBIQUITINATION2 Is Involved in Anther Development by Regulating Tapetum Degradation-Related Genes in Rice.
Topics: Arabidopsis Proteins; Epigenesis, Genetic; Flowers; Gene Expression Regulation, Plant; Histone Code; Histones; Lysine; Methylation; Models, Biological; Mutation; Oryza; Phenotype; Plant Proteins; Seeds; Ubiquitin-Protein Ligases; Ubiquitination | 2015 |
Phosphatidylinositol-4-phosphate 5-Kinase 1α Modulates Ribosomal RNA Gene Silencing through Its Interaction with Histone H3 Lysine 9 Trimethylation and Heterochromatin Protein HP1-α.
Topics: Cell Cycle; Cell Line, Tumor; Cell Nucleolus; Chromobox Protein Homolog 5; Chromosomal Proteins, Non-Histone; DNA, Ribosomal; Epigenesis, Genetic; Gene Silencing; HEK293 Cells; Heterochromatin; Histones; Humans; Lysine; MCF-7 Cells; Methylation; Phosphatidylinositol 4,5-Diphosphate; Phosphotransferases (Alcohol Group Acceptor); Signal Transduction; Sumoylation | 2015 |
The H3K4-Methyl Epigenome Regulates Leukemia Stem Cell Oncogenic Potential.
Topics: Animals; Cell Line, Tumor; Cell Transformation, Neoplastic; Cells, Cultured; Epigenesis, Genetic; Gene Expression Profiling; Gene Expression Regulation, Leukemic; HEK293 Cells; Histone-Lysine N-Methyltransferase; Histones; Humans; Interleukin Receptor Common gamma Subunit; Jumonji Domain-Containing Histone Demethylases; Leukemia; Lysine; Methylation; Mice, Inbred C57BL; Mice, Inbred NOD; Mice, Knockout; Mice, SCID; Myeloid-Lymphoid Leukemia Protein; Neoplastic Stem Cells; Nuclear Proteins; Oligonucleotide Array Sequence Analysis; Repressor Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Transplantation, Heterologous | 2015 |
Homocysteine Induces Collagen I Expression by Downregulating Histone Methyltransferase G9a.
Topics: Animals; Base Sequence; Cell Line; Collagen Type I; Collagen Type I, alpha 1 Chain; Down-Regulation; Histocompatibility Antigens; Histone-Lysine N-Methyltransferase; Histones; Homocysteine; Humans; Liver; Lysine; Male; Methylation; Mice; Mice, Inbred C57BL; Promoter Regions, Genetic; Repressor Proteins | 2015 |
The Xist RNA-PRC2 complex at 20-nm resolution reveals a low Xist stoichiometry and suggests a hit-and-run mechanism in mouse cells.
Topics: Animals; Embryo, Mammalian; Embryonic Stem Cells; Enhancer of Zeste Homolog 2 Protein; Epitopes; Female; Fibroblasts; Histones; Imaging, Three-Dimensional; In Situ Hybridization, Fluorescence; Lysine; Methylation; Mice; Polycomb Repressive Complex 2; RNA, Long Noncoding; X Chromosome; X Chromosome Inactivation | 2015 |
Identification of a functional hotspot on ubiquitin required for stimulation of methyltransferase activity on chromatin.
Topics: Amino Acid Sequence; Chromatin; Epigenesis, Genetic; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Methyltransferases; Mutation; Nucleosomes; Protein Binding; Protein Engineering; Protein Processing, Post-Translational; Sequence Homology, Amino Acid; Software; Structure-Activity Relationship; Surface Properties; Ubiquitin; Ubiquitination | 2015 |
Exposure of Human Prostaspheres to Bisphenol A Epigenetically Regulates SNORD Family Noncoding RNAs via Histone Modification.
Topics: Benzhydryl Compounds; Cluster Analysis; CpG Islands; DNA Methylation; Dose-Response Relationship, Drug; Epigenesis, Genetic; Epithelial Cells; Estradiol; Estrogens; Estrogens, Non-Steroidal; Histone Code; Histones; Humans; Lysine; Male; Methylation; Phenols; Prostate; Prostatic Neoplasms; Reverse Transcriptase Polymerase Chain Reaction; RNA, Untranslated; Stem Cells; Transcriptome | 2015 |
Leg regeneration is epigenetically regulated by histone H3K27 methylation in the cricket Gryllus bimaculatus.
Topics: Amino Acid Sequence; Amputation, Surgical; Animals; Body Patterning; Cell Dedifferentiation; Epigenesis, Genetic; Extremities; Genes, Insect; Gryllidae; Histones; Insect Proteins; Joints; Lysine; Methylation; Models, Biological; Molecular Sequence Data; Phenotype; Regeneration; Sequence Homology, Amino Acid; Tibia | 2015 |
iLM-2L: A two-level predictor for identifying protein lysine methylation sites and their methylation degrees by incorporating K-gap amino acid pairs into Chou׳s general PseAAC.
Topics: Algorithms; Amino Acids; Animals; Computational Biology; Lysine; Methylation; Models, Biological; Protein Processing, Post-Translational; Support Vector Machine | 2015 |
Unabridged Analysis of Human Histone H3 by Differential Top-Down Mass Spectrometry Reveals Hypermethylated Proteoforms from MMSET/NSD2 Overexpression.
Topics: Cell Line, Tumor; Epigenesis, Genetic; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Mass Spectrometry; Methylation; Multiple Myeloma; Proteome; Repressor Proteins; Up-Regulation | 2016 |
Polycomb recruitment at the Class II transactivator gene.
Topics: Enhancer of Zeste Homolog 2 Protein; Gene Expression Regulation; Gene Knockdown Techniques; HeLa Cells; Histones; Humans; Interferon-gamma; Lysine; Methylation; Nuclear Proteins; Polycomb Repressive Complex 2; Polycomb-Group Proteins; Promoter Regions, Genetic; Protein Binding; RNA, Messenger; Trans-Activators; Transcription, Genetic; YY1 Transcription Factor | 2015 |
Histone H3K4me3 and H3K27me3 regulatory genes control stable transmission of an epimutation in rice.
Topics: Alleles; DNA Methylation; DNA, Bacterial; Gene Expression Regulation, Plant; Genes, Plant; Histones; Inheritance Patterns; Lysine; Methylation; Mutation; Oryza; Plant Proteins; Plants, Genetically Modified; Tissue Culture Techniques | 2015 |
Growth Inhibition Accompanied by MOB1 Upregulation in Human Acute Lymphoid Leukemia Cells by 3-Deazaneplanocin A.
Topics: Adenosine; Cell Line, Tumor; Cell Proliferation; Chemokine CXCL10; CpG Islands; Histones; Humans; Lysine; Methylation; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Promoter Regions, Genetic; Up-Regulation | 2015 |
DOT1L Activity Promotes Proliferation and Protects Cortical Neural Stem Cells from Activation of ATF4-DDIT3-Mediated ER Stress In Vitro.
Topics: Activating Transcription Factor 4; Animals; Benzimidazoles; Cell Differentiation; Cell Proliferation; Cell Survival; Cells, Cultured; Cerebral Cortex; Endoplasmic Reticulum; Endoplasmic Reticulum Stress; Gene Expression Regulation; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Methyltransferases; Mice; Neural Stem Cells; Neuroprotection; Transcription Factor CHOP; Transcription, Genetic | 2016 |
Histone variant H3.3 provides the heterochromatic H3 lysine 9 tri-methylation mark at telomeres.
Topics: Animals; Cells, Cultured; DNA Damage; Gene Deletion; Heterochromatin; Histone Code; Histones; Lysine; Methylation; Mice; Sister Chromatid Exchange; Telomere; Transcription, Genetic | 2015 |
The Histone Demethylase UTX Promotes Brown Adipocyte Thermogenic Program Via Coordinated Regulation of H3K27 Demethylation and Acetylation.
Topics: Acetylation; Adipocytes, Brown; Animals; Cell Differentiation; Cell Line; Cold Temperature; CREB-Binding Protein; Enhancer of Zeste Homolog 2 Protein; Gene Expression Regulation, Enzymologic; Histone Demethylases; Histones; Ion Channels; Lipid Metabolism; Lysine; Male; Membrane Potential, Mitochondrial; Methylation; Mice; Mitochondrial Proteins; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Polycomb Repressive Complex 2; Promoter Regions, Genetic; Thermogenesis; Transcription Factors; Uncoupling Protein 1 | 2015 |
Epigenetic reprogramming in solid tumors: therapeutic implications of EZH2 gain-of-function mutations.
Topics: Enhancer of Zeste Homolog 2 Protein; Enzyme Inhibitors; Epigenesis, Genetic; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Neoplastic; Histones; Humans; Lysine; Methylation; Molecular Targeted Therapy; Mutation; Neoplasms; Polycomb Repressive Complex 2 | 2015 |
Nucleosome compaction facilitates HP1γ binding to methylated H3K9.
Topics: Chromobox Protein Homolog 5; Chromosomal Proteins, Non-Histone; Histones; Humans; Lysine; Magnesium; Methylation; Nucleosomes; Protein Binding; Protein Isoforms; Protein Multimerization | 2015 |
Hepatitis B virus X protein induces the histone H3 lysine 9 trimethylation on the promoter of p16 gene in hepatocarcinogenesis.
Topics: Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Genes, p16; Hepatitis B virus; Histones; Humans; Liver Neoplasms; Lysine; Methylation; Promoter Regions, Genetic; Trans-Activators; Viral Regulatory and Accessory Proteins | 2015 |
All-trans retinoic acid and rapamycin normalize Hutchinson Gilford progeria fibroblast phenotype.
Topics: Antineoplastic Agents; Blotting, Western; Cell Cycle; Cell Proliferation; Cells, Cultured; DNA-Binding Proteins; Drug Synergism; Fibroblasts; Gene Expression; Histones; Humans; Lamin Type A; Lysine; Membrane Proteins; Methylation; Microscopy, Electron, Transmission; Microscopy, Fluorescence; Nuclear Proteins; Phenotype; Poly (ADP-Ribose) Polymerase-1; Poly(ADP-ribose) Polymerases; Progeria; Reverse Transcriptase Polymerase Chain Reaction; Sirolimus; Tretinoin | 2015 |
RETRACTED: The inner centromere-shugoshin network prevents chromosomal instability.
Topics: BRCA1 Protein; Carcinogenesis; Cell Cycle Proteins; Centromere; Chromatids; Chromatin; Chromosomal Instability; Chromosomal Proteins, Non-Histone; Chromosome Segregation; Cohesins; HeLa Cells; Histones; Humans; Kinetochores; Lysine; Methylation; Microtubules; Retinoblastoma Protein | 2015 |
The Nrde Pathway Mediates Small-RNA-Directed Histone H3 Lysine 27 Trimethylation in Caenorhabditis elegans.
Topics: Animals; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Histones; Lysine; Methylation; RNA Interference; RNA-Binding Proteins; RNA, Double-Stranded; RNA, Helminth; RNA, Small Interfering | 2015 |
Histone H3 Lysine 36 Trimethylation Is Established over the Xist Promoter by Antisense Tsix Transcription and Contributes to Repressing Xist Expression.
Topics: Animals; Cell Line; Down-Regulation; Female; Histones; Lysine; Male; Methylation; Mice; Mutation; Promoter Regions, Genetic; RNA, Long Noncoding; Transcription, Genetic; X Chromosome Inactivation | 2015 |
Late stage modification of receptors identified from dynamic combinatorial libraries.
Topics: Arginine; Binding Sites; Biotinylation; Combinatorial Chemistry Techniques; Glycine; Lysine; Magnetic Resonance Spectroscopy; Methylation; Models, Molecular; Peptides; Protein Processing, Post-Translational; Small Molecule Libraries | 2015 |
The DNA methylation landscape of human melanoma.
Topics: Cell Differentiation; DNA Methylation; Gene Expression Profiling; High-Throughput Nucleotide Sequencing; Histones; Humans; Immunity; Lysine; Melanocytes; Melanoma; Methylation; Transcription Initiation Site | 2015 |
Early enhancer establishment and regulatory locus complexity shape transcriptional programs in hematopoietic differentiation.
Topics: Animals; Cell Differentiation; Cell Lineage; Enhancer Elements, Genetic; Gene Expression Regulation; Hematopoiesis; Hematopoietic Stem Cells; Histones; Humans; Lysine; Methylation; Models, Genetic; Promoter Regions, Genetic; Regression Analysis; Time Factors | 2015 |
Nucleosome competition reveals processive acetylation by the SAGA HAT module.
Topics: Acetylation; Blotting, Western; Histone Acetyltransferases; Histones; Kinetics; Lysine; Methylation; Models, Biological; Nucleosomes; Promoter Regions, Genetic; Protein Binding; Protein Subunits; Schizosaccharomyces pombe Proteins | 2015 |
Dot1l deficiency leads to increased intercalated cells and upregulation of V-ATPase B1 in mice.
Topics: Animals; Anion Exchange Protein 1, Erythrocyte; Aquaporin 2; Aquaporin 3; Down-Regulation; Fluorescent Antibody Technique; Histone-Lysine N-Methyltransferase; Histones; Kidney; Lysine; Methylation; Methyltransferases; Mice; Promoter Regions, Genetic; RNA, Messenger; Up-Regulation; Vacuolar Proton-Translocating ATPases | 2016 |
Methylation of histone H3 lysine 9 occurs during translation.
Topics: HeLa Cells; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Protein Biosynthesis; Protein Methyltransferases; Protein Processing, Post-Translational; Ribosomes | 2015 |
Changes in tri-methylation profile of lysines 4 and 27 of histone H3 in bovine blastocysts after cryopreservation.
Topics: Animals; Blastocyst; Cattle; Cryopreservation; Embryo Transfer; Embryo, Mammalian; Ethylene Glycol; Female; Fertilization in Vitro; Freezing; Histones; Lysine; Methylation; Pregnancy | 2015 |
Histone lysine methylation exhibits a distinct distribution during spermatogenesis in pigs.
Topics: Animals; Epigenesis, Genetic; Gene Expression Regulation; Histones; Lysine; Male; Methylation; Spermatogenesis; Spermatogonia; Swine; Testis | 2015 |
Partitioning heritability by functional annotation using genome-wide association summary statistics.
Topics: Algorithms; Computer Simulation; Disease; Female; Gene Frequency; Genetic Predisposition to Disease; Genome-Wide Association Study; Histones; Humans; Inheritance Patterns; Lysine; Male; Methylation; Models, Genetic; Polymorphism, Single Nucleotide | 2015 |
The Role of Electrostatic Interactions in Binding of Histone H3K4me2/3 to the Sgf29 Tandem Tudor Domain.
Topics: Acetyltransferases; Aspartic Acid; Histones; Lysine; Methylation; Models, Molecular; Protein Binding; Protein Structure, Tertiary; Static Electricity; Thermodynamics | 2015 |
Regulation of Retinal Development via the Epigenetic Modification of Histone H3.
Topics: Animals; Enhancer of Zeste Homolog 2 Protein; Epigenesis, Genetic; Gene Expression Regulation, Developmental; Histone Demethylases; Histones; Jumonji Domain-Containing Histone Demethylases; Lysine; Methylation; Mice, Inbred ICR; Polycomb Repressive Complex 2; Retina; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference | 2016 |
The SET Domain Is Essential for Metnase Functions in Replication Restart and the 5' End of SS-Overhang Cleavage.
Topics: Base Sequence; DNA Damage; DNA End-Joining Repair; DNA Replication; DNA, Single-Stranded; HEK293 Cells; Histone-Lysine N-Methyltransferase; Histones; Humans; Hydroxyurea; Lysine; Methylation; Molecular Sequence Data; Oxidoreductases, N-Demethylating; Protein Processing, Post-Translational; Protein Structure, Tertiary; Recombinant Fusion Proteins; Sequence Deletion | 2015 |
The PZP Domain of AF10 Senses Unmodified H3K27 to Regulate DOT1L-Mediated Methylation of H3K79.
Topics: Binding Sites; Carcinogenesis; Cell Line, Tumor; Chromatin; Crystallography, X-Ray; Gene Expression Regulation, Leukemic; Histone-Lysine N-Methyltransferase; Histones; Humans; Hydrogen Bonding; Leukocytes; Lysine; Methylation; Methyltransferases; Models, Molecular; Protein Binding; Protein Interaction Domains and Motifs; Signal Transduction; Transcription Factors | 2015 |
Inhibition of H3K9 histone methyltransferase G9a attenuates renal fibrosis and retains klotho expression.
Topics: Actins; Animals; Antibodies, Neutralizing; Azepines; Cell Line; Enzyme Inhibitors; Fibroblasts; Fibronectins; Fibrosis; Glomerulonephritis, IGA; Glucuronidase; Histocompatibility Antigens; Histone-Lysine N-Methyltransferase; Histones; Humans; Kidney; Klotho Proteins; Lysine; Male; Methylation; Mice; Quinazolines; Rats; RNA, Messenger; RNA, Small Interfering; Transforming Growth Factor beta1; Ureteral Obstruction | 2016 |
Alternative transcription initiation leads to expression of a novel ALK isoform in cancer.
Topics: Alleles; Anaplastic Lymphoma Kinase; Animals; Cell Line, Tumor; Cell Proliferation; Cell Transformation, Neoplastic; Female; Gene Expression Regulation, Neoplastic; HEK293 Cells; Histones; Humans; Introns; Isoenzymes; Lysine; Methylation; Mice; Molecular Sequence Data; Molecular Weight; Neoplasms; NIH 3T3 Cells; Oncogenes; Protein Structure, Tertiary; Receptor Protein-Tyrosine Kinases; RNA Polymerase II; RNA, Messenger; Signal Transduction; Transcription Initiation, Genetic | 2015 |
Hsp70 (HSPA1) Lysine Methylation Status as a Potential Prognostic Factor in Metastatic High-Grade Serous Carcinoma.
Topics: Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Breast Neoplasms; Female; HSP70 Heat-Shock Proteins; Humans; Kaplan-Meier Estimate; Lysine; Methylation; Middle Aged; Neoplasm Grading; Neoplasms, Cystic, Mucinous, and Serous; Ovarian Neoplasms; Prognosis; Proportional Hazards Models; Protein Processing, Post-Translational | 2015 |
Sulforaphane modulates telomerase activity via epigenetic regulation in prostate cancer cell lines.
Topics: Acetylation; Cell Line, Tumor; Chromatin; Chromatin Immunoprecipitation; Epigenesis, Genetic; Histone Deacetylase Inhibitors; Histones; Humans; Isothiocyanates; Lysine; Male; Methyl-CpG-Binding Protein 2; Methylation; Nucleosomes; Phytochemicals; Promoter Regions, Genetic; Prostatic Neoplasms; Protein Processing, Post-Translational; Sulfoxides; Telomerase; Transcription, Genetic | 2016 |
H3K23me2 is a new heterochromatic mark in Caenorhabditis elegans.
Topics: Acetylation; Animals; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Chromosomal Proteins, Non-Histone; Co-Repressor Proteins; Embryo, Nonmammalian; Embryonic Development; Germ Cells; Heterochromatin; Histone Code; Histone Demethylases; Histones; Lysine; Methylation; Protein Processing, Post-Translational | 2015 |
ZFP57 recognizes multiple and closely spaced sequence motif variants to maintain repressive epigenetic marks in mouse embryonic stem cells.
Topics: Alleles; Animals; Base Sequence; Cell Line; Chromatin Immunoprecipitation; DNA Methylation; Genomic Imprinting; Histones; Lysine; Methylation; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Mouse Embryonic Stem Cells; Mutation; Nuclear Proteins; Nucleotide Motifs; Polymorphism, Single Nucleotide; Protein Binding; Repressor Proteins; Tripartite Motif-Containing Protein 28 | 2016 |
LncRNA ontology: inferring lncRNA functions based on chromatin states and expression patterns.
Topics: Algorithms; Cell Line; Cell Line, Tumor; Cells, Cultured; Chromatin; Gene Expression Profiling; Gene Ontology; Gene Regulatory Networks; HeLa Cells; Hep G2 Cells; Histones; Humans; K562 Cells; Lysine; Methylation; Models, Genetic; Neoplasms; Promoter Regions, Genetic; RNA, Long Noncoding; RNA, Messenger; Transcription Initiation Site | 2015 |
Natural variation of H3K27me3 modification in two Arabidopsis accessions and their hybrid.
Topics: Alleles; Arabidopsis; Arabidopsis Proteins; Crosses, Genetic; Ecotype; Gene Expression Regulation, Plant; Genetic Variation; Genome, Plant; Histones; Homeodomain Proteins; Hybridization, Genetic; Lysine; Methylation; Mutation; Transcriptome | 2016 |
Mutual regulation between CHD5 and EZH2 in hepatocellular carcinoma.
Topics: Blotting, Western; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Movement; Chi-Square Distribution; DNA Helicases; Enhancer of Zeste Homolog 2 Protein; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Histones; Humans; Kaplan-Meier Estimate; Liver Neoplasms; Lysine; Male; Methylation; Middle Aged; Nerve Tissue Proteins; Polycomb Repressive Complex 2; Promoter Regions, Genetic; Protein Binding; Reverse Transcriptase Polymerase Chain Reaction | 2015 |
Lysine Methylation of the Valosin-Containing Protein (VCP) Is Dispensable for Development and Survival of Mice.
Topics: Adenosine Triphosphatases; Animals; Cell Cycle Proteins; Female; Fertility; Gene Expression Regulation, Developmental; Gene Knockout Techniques; Growth and Development; Humans; Lysine; Male; Methylation; Methyltransferases; Mice; Phenotype; Substrate Specificity; Survival Analysis; Valosin Containing Protein | 2015 |
Novel N-terminal and Lysine Methyltransferases That Target Translation Elongation Factor 1A in Yeast and Human.
Topics: Chromatography, Liquid; Electrophoresis, Polyacrylamide Gel; Lysine; Mass Spectrometry; Methylation; Methyltransferases; Mutation; Peptide Elongation Factor 1; Protein Processing, Post-Translational; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins | 2016 |
Histone chaperone CAF-1 mediates repressive histone modifications to protect preimplantation mouse embryos from endogenous retrotransposons.
Topics: Animals; Blastocyst; Cell Nucleus; Chromatin Assembly Factor-1; Chromatin Immunoprecipitation; Female; Gene Knockdown Techniques; Genes, Dominant; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Lysine; Male; Methylation; Mice; Mouse Embryonic Stem Cells; Mutation; Promoter Regions, Genetic; Protein Processing, Post-Translational; Retroelements; Reverse Transcriptase Inhibitors; RNA, Messenger; RNA, Small Interfering | 2015 |
Histone methylation levels correlate with TGFBIp and extracellular matrix gene expression in normal and granular corneal dystrophy type 2 corneal fibroblasts.
Topics: Cornea; Corneal Dystrophies, Hereditary; Extracellular Matrix; Extracellular Matrix Proteins; Fibroblasts; Gene Expression Regulation; Gene Knockdown Techniques; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Homozygote; Humans; Lysine; Methylation; Myeloid-Lymphoid Leukemia Protein; Protein Transport; Smad3 Protein; Transcription, Genetic; Transforming Growth Factor beta; Transforming Growth Factor beta1 | 2015 |
Aberrant intracellular localization of H3k4me3 demonstrates an early epigenetic phenomenon in Alzheimer's disease.
Topics: Aged; Aged, 80 and over; Alzheimer Disease; Epigenesis, Genetic; Female; Gene Expression; Histones; Humans; Lysine; Male; Methylation; Middle Aged; Transcription, Genetic; Transcriptional Activation | 2015 |
Analysis of JmjC Demethylase-Catalyzed Demethylation Using Geometrically-Constrained Lysine Analogues.
Topics: Binding Sites; Catalysis; Jumonji Domain-Containing Histone Demethylases; Lysine; Methylation; Substrate Specificity | 2016 |
Superresolution imaging reveals structurally distinct periodic patterns of chromatin along pachytene chromosomes.
Topics: Animals; Centromere; Chromatin; Chromosomes, Mammalian; Histones; Lysine; Methylation; Mice; Microscopy; Models, Biological; Pachytene Stage; Synaptonemal Complex; Transcription, Genetic | 2015 |
Site-specific methylation and acetylation of lysine residues in the C-terminal domain (CTD) of RNA polymerase II.
Topics: Acetylation; Antibodies, Monoclonal; Cell Line; Gene Expression Regulation; Humans; Lysine; Mass Spectrometry; Methylation; Models, Molecular; Protein Structure, Tertiary; RNA Polymerase II; Transcription Initiation, Genetic | 2015 |
The metabolome regulates the epigenetic landscape during naive-to-primed human embryonic stem cell transition.
Topics: Animals; Blotting, Western; Cell Differentiation; Cells, Cultured; Embryonic Stem Cells; Epigenesis, Genetic; Gas Chromatography-Mass Spectrometry; Gene Expression Profiling; Gene Knockdown Techniques; Histones; Human Embryonic Stem Cells; Humans; Lysine; Mass Spectrometry; Metabolome; Metabolomics; Methylation; Mice; Niacinamide; Nicotinamide N-Methyltransferase; Proteomics; Reverse Transcriptase Polymerase Chain Reaction; S-Adenosylmethionine; Signal Transduction | 2015 |
Cavitands Endow All-Dielectric Beads With Selectivity for Plasmon-Free Enhanced Raman Detection of Nε-Methylated Lysine.
Topics: Ethers, Cyclic; Lysine; Methylation; Resorcinols; Silicon Dioxide; Spectrum Analysis, Raman | 2016 |
Chemical basis for the recognition of trimethyllysine by epigenetic reader proteins.
Topics: Acetyltransferases; Amino Acids, Aromatic; Antigens, Nuclear; Calorimetry; Crystallography, X-Ray; Epigenesis, Genetic; Histone Code; Histones; Humans; Jumonji Domain-Containing Histone Demethylases; Lysine; Methylation; Models, Molecular; Molecular Dynamics Simulation; Nerve Tissue Proteins; Quaternary Ammonium Compounds; Retinoblastoma-Binding Protein 2; TATA-Binding Protein Associated Factors; Transcription Factor TFIID; Transcription Factors | 2015 |
Linker histone H1.2 establishes chromatin compaction and gene silencing through recognition of H3K27me3.
Topics: Cell Line, Tumor; Cell Proliferation; Chromatin; Enhancer of Zeste Homolog 2 Protein; Gene Silencing; Genetic Loci; Histones; Humans; Lysine; Methylation; Nucleosomes; Polycomb Repressive Complex 2; Protein Binding; Transcription, Genetic | 2015 |
Global mapping of the regulatory interactions of histone residues.
Topics: Acetylation; Acetyltransferases; Chromatin Assembly and Disassembly; Databases, Nucleic Acid; Gene Expression Profiling; Gene Expression Regulation, Bacterial; Histone-Lysine N-Methyltransferase; Histones; Jumonji Domain-Containing Histone Demethylases; Lysine; Methylation; Methyltransferases; Nucleosomes; Oligonucleotide Array Sequence Analysis; Point Mutation; Protein Interaction Mapping; Protein Processing, Post-Translational; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Transcription, Genetic | 2015 |
Inhibiting WEE1 Selectively Kills Histone H3K36me3-Deficient Cancers by dNTP Starvation.
Topics: Amino Acid Sequence; Animals; Base Sequence; Blotting, Western; Cell Cycle Proteins; Cell Line, Tumor; Cell Survival; Gene Expression Regulation, Neoplastic; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Mice, Inbred BALB C; Mice, Nude; Molecular Sequence Data; Neoplasms; Nuclear Proteins; Nucleotides; Protein-Tyrosine Kinases; Pyrazoles; Pyrimidines; Pyrimidinones; Reverse Transcriptase Polymerase Chain Reaction; Ribonucleoside Diphosphate Reductase; RNA Interference; Sequence Homology, Amino Acid; Sequence Homology, Nucleic Acid; Xenograft Model Antitumor Assays | 2015 |
Quantitative Histone Mass Spectrometry Identifies Elevated Histone H3 Lysine 27 (Lys27) Trimethylation in Melanoma.
Topics: Cadherins; Cell Line, Tumor; Core Binding Factor Alpha 1 Subunit; Enhancer of Zeste Homolog 2 Protein; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Histones; Humans; Lysine; Mass Spectrometry; Methylation; Multiple Myeloma; Neoplasm Metastasis; Protein Processing, Post-Translational; Up-Regulation | 2016 |
Dynamically reorganized chromatin is the key for the reprogramming of somatic cells to pluripotent cells.
Topics: Animals; Ascorbic Acid; Cellular Reprogramming; Chromatin; CpG Islands; Gene Expression Regulation; Histones; Induced Pluripotent Stem Cells; Lysine; Methylation; Mice; Nucleosomes; Promoter Regions, Genetic; Transcriptome | 2015 |
The Dynamics and Regulatory Mechanism of Pronuclear H3k9me2 Asymmetry in Mouse Zygotes.
Topics: Animals; Azepines; Cell Nucleus; Fertilization in Vitro; Histone-Lysine N-Methyltransferase; Histones; Kruppel-Like Transcription Factors; Lysine; Methylation; Mice; Microinjections; Models, Biological; Nerve Tissue Proteins; Quinazolines; RNA, Small Interfering; Zygote | 2015 |
ASXL2 promotes proliferation of breast cancer cells by linking ERα to histone methylation.
Topics: Animals; Biomarkers, Tumor; Blotting, Western; Breast Neoplasms; Cell Proliferation; DNA-Binding Proteins; Estrogen Receptor alpha; Female; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; HEK293 Cells; Histone Demethylases; Histones; Humans; Lysine; MCF-7 Cells; Methylation; Mice, Inbred BALB C; Mice, Nude; Neoplasm Proteins; Prognosis; Protein Binding; Repressor Proteins; Reverse Transcriptase Polymerase Chain Reaction; Transplantation, Heterologous | 2016 |
JMJ704 positively regulates rice defense response against Xanthomonas oryzae pv. oryzae infection via reducing H3K4me2/3 associated with negative disease resistance regulators.
Topics: Blotting, Western; Disease Resistance; Gene Expression Profiling; Gene Expression Regulation, Plant; Gene Knockdown Techniques; Genes, Plant; Histones; Lysine; Methylation; Mutation; Oryza; Plant Diseases; Plant Proteins; Real-Time Polymerase Chain Reaction; Sequence Analysis, RNA; Time Factors; Xanthomonas | 2015 |
Analysis of histone modifications at human ribosomal DNA in liver cancer cell.
Topics: Blotting, Western; CCCTC-Binding Factor; Chromatin Immunoprecipitation; DNA, Ribosomal; Gene Expression Regulation, Neoplastic; Hep G2 Cells; Histone Code; Histones; Humans; Liver Neoplasms; Lysine; Methylation; Pol1 Transcription Initiation Complex Proteins; Promoter Regions, Genetic; Protein Processing, Post-Translational; Repressor Proteins; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference | 2015 |
Type 2 cannabinoid receptor contributes to the physiological regulation of spermatogenesis.
Topics: Animals; Blotting, Western; Cannabinoids; Cell Differentiation; Cells, Cultured; Gene Expression; Histone-Lysine N-Methyltransferase; Histones; Indoles; Lysine; Male; Meiosis; Methylation; Mice; Microscopy, Fluorescence; Promoter Regions, Genetic; Receptor, Cannabinoid, CB2; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Spermatogenesis; Spermatogonia; Tretinoin | 2016 |
Pseudomonas aeruginosa EftM Is a Thermoregulated Methyltransferase.
Topics: Amino Acid Substitution; Bacterial Proteins; Binding Sites; Computational Biology; Enzyme Stability; Isoenzymes; Lysine; Methylation; Models, Molecular; Mutation; Peptide Elongation Factor Tu; Protein Conformation; Protein Methyltransferases; Protein Processing, Post-Translational; Protein Unfolding; Pseudomonas aeruginosa; Recombinant Fusion Proteins; S-Adenosylmethionine; Sequence Homology, Amino Acid; Substrate Specificity; Temperature | 2016 |
Identification of the Post-translational Modifications Present in Centromeric Chromatin.
Topics: Autoantigens; Cell Cycle; Centromere; Centromere Protein A; Chromosomal Proteins, Non-Histone; DNA-Binding Proteins; HeLa Cells; Histones; Humans; Lysine; Methylation; Nucleosomes; Protein Processing, Post-Translational; Serine; Spectrometry, Mass, Electrospray Ionization | 2016 |
Methylation of RNA polymerase II non-consensus Lysine residues marks early transcription in mammalian cells.
Topics: Animals; Consensus; Gene Expression Regulation; Lysine; Methylation; Mice; NIH 3T3 Cells; Phosphorylation; Protein Processing, Post-Translational; RNA Polymerase II; Serine; Transcription, Genetic | 2015 |
Myocardin-related transcription factor A (MRTF-A) plays an essential role in hepatic stellate cell activation by epigenetically modulating TGF-β signaling.
Topics: Animals; Cell Line; Epigenesis, Genetic; Hepatic Stellate Cells; Histones; Liver Cirrhosis; Lysine; Male; Methylation; Mice; Promoter Regions, Genetic; Rats; Signal Transduction; Trans-Activators; Transcriptional Activation; Transforming Growth Factor beta | 2016 |
Reader interactome of epigenetic histone marks in birds.
Topics: Amino Acid Sequence; Animals; Avian Proteins; Cell Line; Chickens; Chromatin; Epigenesis, Genetic; Finches; Histone Code; Histones; Humans; Lysine; Methylation; Molecular Sequence Data; Polycomb-Group Proteins; Protein Interaction Mapping; Protein Processing, Post-Translational; Proteomics; Sequence Alignment; Transcription Factors; Transposases; Zinc Fingers | 2016 |
Epigenetic Regulation of Vegetative Phase Change in Arabidopsis.
Topics: Acetylation; Arabidopsis; Arabidopsis Proteins; Epigenesis, Genetic; Gene Expression Regulation, Plant; Histones; Lysine; Methylation; MicroRNAs; Nucleosomes; Protein Binding; Repressor Proteins; Transcription, Genetic | 2016 |
SET8 induces epithelial‑mesenchymal transition and enhances prostate cancer cell metastasis by cooperating with ZEB1.
Topics: Cadherins; Cell Line, Tumor; Epithelial-Mesenchymal Transition; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Histone-Lysine N-Methyltransferase; Histones; Homeodomain Proteins; Humans; Lysine; Male; Methylation; Neoplasm Metastasis; Prostatic Neoplasms; Protein Binding; Transcription Factors; Transcription, Genetic; Vimentin; Zinc Finger E-box-Binding Homeobox 1 | 2016 |
Epigenomic Landscape of Human Fetal Brain, Heart, and Liver.
Topics: Aborted Fetus; Biomarkers; Brain; China; Chromatin; Databases, Nucleic Acid; Epigenesis, Genetic; Gene Expression Regulation, Developmental; Gene Ontology; Genomic Library; Heart; High-Throughput Nucleotide Sequencing; Histones; Humans; Liver; Lysine; Methylation; Myocardium; Organ Specificity; Protein Processing, Post-Translational; Sequence Analysis, DNA; Species Specificity | 2016 |
HDAC inhibitors induce global changes in histone lysine and arginine methylation and alter expression of lysine demethylases.
Topics: Arginine; Gene Expression Regulation, Enzymologic; HEK293 Cells; Histone Deacetylase Inhibitors; Histone Demethylases; Histones; Humans; K562 Cells; Lysine; Methylation; Tandem Mass Spectrometry | 2016 |
Regulation of Methyllysine Readers through Phosphorylation.
Topics: Binding Sites; Chromatin; Epigenesis, Genetic; Histones; Humans; Lysine; Methylation; Models, Molecular; Nuclear Proteins; Phosphorylation; Protein Binding; Protein Conformation; Protein Processing, Post-Translational | 2016 |
Histone Deacetylase 1 (HDAC1) Negatively Regulates Thermogenic Program in Brown Adipocytes via Coordinated Regulation of Histone H3 Lysine 27 (H3K27) Deacetylation and Methylation.
Topics: Acetylation; Adipocytes, Brown; Adrenergic beta-3 Receptor Agonists; Animals; Cell Line, Transformed; Enhancer of Zeste Homolog 2 Protein; Gene Expression Regulation; Histone Deacetylase 1; Histones; Humans; Ion Channels; Lysine; Methylation; Mice, Inbred Strains; Mitochondrial Proteins; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Polycomb Repressive Complex 1; Polycomb Repressive Complex 2; Promoter Regions, Genetic; Protein Processing, Post-Translational; Recombinant Proteins; RNA Interference; Thermogenesis; Transcription Factors; Ubiquitin-Protein Ligases; Uncoupling Protein 1 | 2016 |
Quantitative Profiling of the Activity of Protein Lysine Methyltransferase SMYD2 Using SILAC-Based Proteomics.
Topics: Amino Acid Motifs; Benzamides; Carcinoma, Squamous Cell; Cell Culture Techniques; Cell Line, Tumor; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Gene Expression Regulation, Neoplastic; Histone-Lysine N-Methyltransferase; Humans; Isotope Labeling; Lysine; Mass Spectrometry; Methylation; Proteome; Proteomics; Pyrrolidines; Substrate Specificity | 2016 |
Genome-wide profiling of histone H3 lysine 27 and lysine 4 trimethylation in multiple myeloma reveals the importance of Polycomb gene targeting and highlights EZH2 as a potential therapeutic target.
Topics: Chromatin; Down-Regulation; Enhancer of Zeste Homolog 2 Protein; Enzyme Inhibitors; Gene Expression Profiling; Histones; Humans; Lysine; Methylation; Molecular Targeted Therapy; Multiple Myeloma; Polycomb-Group Proteins | 2016 |
Hypoacetylation, hypomethylation, and dephosphorylation of H2B histones and excessive histone deacetylase activity in DU-145 prostate cancer cells.
Topics: Acetylation; Amino Acid Sequence; Butyric Acid; Cell Line; Cell Line, Tumor; Chromatography, Liquid; Histone Deacetylase Inhibitors; Histone Deacetylases; Histones; Humans; Lysine; Male; Methylation; Molecular Sequence Data; Phosphorylation; Prostatic Neoplasms; Protein Processing, Post-Translational; Tandem Mass Spectrometry; Threonine | 2016 |
Transition state for the NSD2-catalyzed methylation of histone H3 lysine 36.
Topics: Catalysis; HeLa Cells; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Models, Molecular; Repressor Proteins | 2016 |
Yin Yang 1-mediated epigenetic silencing of tumour-suppressive microRNAs activates nuclear factor-κB in hepatocellular carcinoma.
Topics: Animals; Apoptosis; Binding Sites; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; DNA Methylation; Enhancer of Zeste Homolog 2 Protein; Gene Expression Regulation, Neoplastic; Gene Silencing; Histones; Humans; Liver Neoplasms; Lysine; Methylation; Mice, Nude; Mice, Transgenic; MicroRNAs; NF-kappa B; Polycomb Repressive Complex 2; Promoter Regions, Genetic; RNA Interference; Signal Transduction; Time Factors; Trans-Activators; Transfection; Tumor Burden; Up-Regulation; Viral Regulatory and Accessory Proteins; YY1 Transcription Factor | 2016 |
A Mouse Model of X-linked Intellectual Disability Associated with Impaired Removal of Histone Methylation.
Topics: Aggression; Animals; Brain; CpG Islands; Dendritic Spines; Disease Models, Animal; Gene Expression Regulation; Genes, X-Linked; Histone Demethylases; Histones; Intellectual Disability; Lysine; Memory; Methylation; Mice, Knockout; Oxidoreductases, N-Demethylating; Promoter Regions, Genetic; Social Behavior; Transcription, Genetic | 2016 |
The H3K4me3/2 histone demethylase RBR-2 controls axon guidance by repressing the actin-remodeling gene wsp-1.
Topics: Actins; Alleles; Animals; Axons; Body Patterning; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Catalysis; Chromatin; Chromosomal Proteins, Non-Histone; Epigenesis, Genetic; Gene Expression Regulation, Developmental; Histone Demethylases; Histones; Lysine; Methylation; Microscopy, Fluorescence; Mutation; Neurons; Protein Structure, Tertiary; Retinoblastoma-Binding Protein 2; Signal Transduction; Transgenes | 2016 |
PAK4 Methylation by SETD6 Promotes the Activation of the Wnt/β-Catenin Pathway.
Topics: beta Catenin; Cell Line, Tumor; Chromatin; Cloning, Molecular; Escherichia coli; Gene Expression; Gene Knockout Techniques; HEK293 Cells; Humans; Lysine; Methylation; p21-Activated Kinases; Protein Binding; Protein Methyltransferases; Protein Processing, Post-Translational; Recombinant Proteins; Transcription, Genetic; Wnt Signaling Pathway | 2016 |
Dynamic Histone Acetylation of H3K4me3 Nucleosome Regulates MCL1 Pre-mRNA Splicing.
Topics: Acetylation; Cell Line, Tumor; Chromatin; Histone Acetyltransferases; Histone Deacetylases; Histones; Humans; Lysine; Methylation; Myeloid Cell Leukemia Sequence 1 Protein; Nucleosomes; Protein Processing, Post-Translational; RNA Precursors; RNA Splicing | 2016 |
Desensitization and Incomplete Recovery of Hepatic Target Genes After Chronic Thyroid Hormone Treatment and Withdrawal in Male Adult Mice.
Topics: Acetylation; Animals; Gene Expression Profiling; Histones; Liver; Lysine; Male; Methylation; Mice, Inbred C57BL; Oligonucleotide Array Sequence Analysis; Reverse Transcriptase Polymerase Chain Reaction; Thyrotropin; Thyroxine; Time Factors; Transcriptome; Triiodothyronine | 2016 |
A Novel Epigenetic Silencing Pathway Involving the Highly Conserved 5'-3' Exoribonuclease Dhp1/Rat1/Xrn2 in Schizosaccharomyces pombe.
Topics: Amino Acid Sequence; Biocatalysis; Centromere; Chromosome Segregation; Conserved Sequence; DNA-Directed RNA Polymerases; Epigenesis, Genetic; Exoribonucleases; Exosomes; Gene Silencing; Genes, Mating Type, Fungal; Genetic Loci; Heterochromatin; Histones; Lysine; Methylation; Molecular Sequence Data; Mutation; Protein Binding; RNA, Messenger; Schizosaccharomyces; Schizosaccharomyces pombe Proteins; Terminator Regions, Genetic | 2016 |
Identification of a small-molecule ligand of the epigenetic reader protein Spindlin1 via a versatile screening platform.
Topics: Cell Cycle Proteins; Cell Line, Tumor; Epigenesis, Genetic; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; HL-60 Cells; Humans; Jumonji Domain-Containing Histone Demethylases; Ligands; Lysine; Methylation; Microtubule-Associated Proteins; Phosphoproteins; Protein Binding; Protein Domains; Protein Processing, Post-Translational | 2016 |
Regulation of Transcription Factor Yin Yang 1 by SET7/9-mediated Lysine Methylation.
Topics: Cell Proliferation; CRISPR-Cas Systems; HEK293 Cells; HeLa Cells; Histone-Lysine N-Methyltransferase; Humans; Lysine; Methylation; Plasmids; Protein Domains; Protein Processing, Post-Translational; Recombinant Proteins; RNA, Small Interfering; Transcription, Genetic; Transfection; YY1 Transcription Factor | 2016 |
KMT2D regulates specific programs in heart development via histone H3 lysine 4 di-methylation.
Topics: Animals; Aorta; Cell Cycle; Echocardiography; Electrophysiology; Enhancer Elements, Genetic; Female; Gene Deletion; Gene Expression Profiling; Gene Expression Regulation, Developmental; Heart; Heart Ventricles; Histone-Lysine N-Methyltransferase; Histones; Hypoxia; Lysine; Methylation; Mice; Microscopy, Fluorescence; Myeloid-Lymphoid Leukemia Protein; Myocardium; Myocytes, Cardiac; Oxygen; Promoter Regions, Genetic; Sequence Analysis, RNA | 2016 |
Extended string-like binding of the phosphorylated HP1α N-terminal tail to the lysine 9-methylated histone H3 tail.
Topics: Chromobox Protein Homolog 5; Chromosomal Proteins, Non-Histone; Histones; Humans; Lysine; Methylation; Nuclear Magnetic Resonance, Biomolecular; Phosphorylation; Protein Binding; Protein Domains | 2016 |
CURLY LEAF Regulates Gene Sets Coordinating Seed Size and Lipid Biosynthesis.
Topics: Arabidopsis; Arabidopsis Proteins; Cell Size; Gene Expression Regulation, Plant; Homeodomain Proteins; Lipids; Lysine; Methylation; Polycomb Repressive Complex 2; Repressor Proteins; Seeds | 2016 |
Uropathogenic E. coli (UPEC) Infection Induces Proliferation through Enhancer of Zeste Homologue 2 (EZH2).
Topics: Cell Line; Cell Proliferation; Enhancer of Zeste Homolog 2 Protein; Epigenesis, Genetic; Escherichia coli Infections; Histones; Humans; Lysine; Methylation; Paracrine Communication; Polycomb Repressive Complex 2; Proto-Oncogene Proteins; Uropathogenic Escherichia coli; Urothelium; Wnt Proteins; Wnt-5a Protein | 2016 |
Pharmacological inhibition of LSD1 for the treatment of MLL-rearranged leukemia.
Topics: Animals; Blotting, Western; Cell Line, Tumor; Cell Proliferation; Child; Drug Synergism; Enzyme Inhibitors; Gene Expression Regulation, Leukemic; Gene Rearrangement; Histone Demethylases; Histone-Lysine N-Methyltransferase; Histones; Humans; Leukemia; Lysine; MCF-7 Cells; Methylation; Methyltransferases; Mice, Inbred NOD; Mice, SCID; Molecular Structure; Monoamine Oxidase Inhibitors; Myeloid-Lymphoid Leukemia Protein; Reverse Transcriptase Polymerase Chain Reaction; U937 Cells; Xenograft Model Antitumor Assays | 2016 |
Role of annexin gene and its regulation during zebrafish caudal fin regeneration.
Topics: Amputation, Surgical; Animal Fins; Animals; Annexins; Blotting, Western; Disease Models, Animal; Epigenesis, Genetic; Gene Expression Regulation, Developmental; Histones; Lysine; Methylation; Promoter Regions, Genetic; Real-Time Polymerase Chain Reaction; Regeneration; Zebrafish | 2016 |
Supramolecular Affinity Chromatography for Methylation-Targeted Proteomics.
Topics: Animals; Calixarenes; Cattle; Chromatography, Affinity; Histones; Lysine; Methylation; Peptides; Proteomics | 2016 |
Regulation of HIF-1α stability by lysine methylation.
Topics: Animals; Cell Line, Tumor; Embryo, Mammalian; Fibroblasts; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Lysine; Methylation; Mice; Models, Biological; Protein Stability | 2016 |
A positive role for polycomb in transcriptional regulation via H4K20me1.
Topics: Animals; Base Sequence; Biomarkers; Drosophila melanogaster; Drosophila Proteins; Gene Expression Regulation, Developmental; Histones; Lysine; Methylation; Nuclear Proteins; Polycomb Repressive Complex 1; Repressor Proteins; Transcription Factors; Transcription, Genetic; Wings, Animal | 2016 |
Neuronal activity controls Bdnf expression via Polycomb de-repression and CREB/CBP/JMJD3 activation in mature neurons.
Topics: Acetylation; Animals; Brain-Derived Neurotrophic Factor; Cell Differentiation; CREB-Binding Protein; Cyclic AMP Response Element-Binding Protein; Enhancer of Zeste Homolog 2 Protein; Epigenesis, Genetic; Gene Expression Regulation, Developmental; Hippocampus; Histones; Jumonji Domain-Containing Histone Demethylases; Long-Term Synaptic Depression; Lysine; Methylation; Models, Biological; N-Methylaspartate; Neurons; Phosphorylation; Polycomb Repressive Complex 2; Polycomb-Group Proteins; Promoter Regions, Genetic; Rats, Wistar | 2016 |
Retrotransposon derepression leads to activation of the unfolded protein response and apoptosis in pro-B cells.
Topics: Animals; Apoptosis; Gene Expression Profiling; Gene Silencing; HEK293 Cells; Histone-Lysine N-Methyltransferase; Histones; Humans; Leukemia Virus, Murine; Lysine; Methylation; Mice; Precursor Cells, B-Lymphoid; Repetitive Sequences, Nucleic Acid; Retroelements; Transcription, Genetic; Unfolded Protein Response | 2016 |
LSD1 Mediates Neuronal Differentiation of Human Fetal Neural Stem Cells by Controlling the Expression of a Novel Target Gene, HEYL.
Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Cell Differentiation; Cell Proliferation; Chromatin; Fetus; Gene Expression Regulation; Histone Demethylases; Histones; Humans; Lysine; Methylation; Mice, Inbred ICR; Neocortex; Neural Stem Cells; Neurogenesis; Neurons; Promoter Regions, Genetic; Repressor Proteins | 2016 |
A charge-suppressing strategy for probing protein methylation.
Topics: Amino Acid Sequence; Arginine; Chromatography, Ion Exchange; Lysine; Mass Spectrometry; Methylation; Peptides; Proteins | 2016 |
Identification and characterization of histone lysine methylation modifiers in Fragaria vesca.
Topics: Alternative Splicing; Databases, Protein; Epigenesis, Genetic; Fragaria; Fruit; Gene Expression Regulation, Plant; Genes, Plant; Histone Demethylases; Histones; Jumonji Domain-Containing Histone Demethylases; Lysine; Methylation; Methyltransferases; Phylogeny; Plant Proteins; Proteome; Retroelements; Transcriptome | 2016 |
H3K4me3 Demethylase Kdm5a Is Required for NK Cell Activation by Associating with p50 to Suppress SOCS1.
Topics: Animals; Base Sequence; Cell Nucleus; Chromatin; Disease Resistance; HEK293 Cells; Histones; Humans; Inflammation; Interleukin-12; Janus Kinase 2; Killer Cells, Natural; Listeria monocytogenes; Listeriosis; Lymphocyte Activation; Lysine; Methylation; Mice; NF-kappa B p50 Subunit; Phosphorylation; Promoter Regions, Genetic; Protein Transport; Retinoblastoma-Binding Protein 2; Signal Transduction; STAT4 Transcription Factor; Suppressor of Cytokine Signaling 1 Protein | 2016 |
Unexpected Distinct Roles of the Related Histone H3 Lysine 9 Methyltransferases G9a and G9a-Like Protein in Myoblasts.
Topics: Animals; Cell Differentiation; Cell Line; Gene Expression; Gene Expression Profiling; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Mice; Muscle Development; Myoblasts | 2016 |
Identification and functional characterization of lysine methyltransferases of Entamoeba histolytica.
Topics: Amino Acid Sequence; Entamoeba histolytica; Epigenesis, Genetic; Histones; Lysine; Methylation; Methyltransferases; Protein Processing, Post-Translational; Trophozoites | 2016 |
Histone H4 lysine 20 acetylation is associated with gene repression in human cells.
Topics: Acetylation; Animals; Antibodies, Monoclonal; Binding Sites; Chromatin Immunoprecipitation; Chromatography, High Pressure Liquid; HeLa Cells; Histones; Humans; Lysine; Methylation; Mice; Microscopy, Fluorescence; Peptides; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Transcription Factors; Transcription Initiation Site | 2016 |
Polycomb Ezh2 controls the fate of GABAergic neurons in the embryonic cerebellum.
Topics: Animals; Cell Count; Cell Lineage; Cell Proliferation; Cerebellum; Enhancer of Zeste Homolog 2 Protein; GABAergic Neurons; Gene Deletion; Gene Expression Regulation, Developmental; Genetic Loci; Genome; Histones; Interneurons; Lysine; Methylation; Mice, Knockout; PAX7 Transcription Factor; Purkinje Cells; Transcription, Genetic; Tumor Suppressor Proteins | 2016 |
Age-associated de-repression of retrotransposons in the Drosophila fat body, its potential cause and consequence.
Topics: Aging; Animals; DNA Damage; Drosophila melanogaster; Drosophila Proteins; Fat Body; Gene Expression Regulation, Developmental; Heterochromatin; Histones; Lamins; Lysine; Methylation; Models, Biological; Retroelements | 2016 |
Differential patterns of histone methylase EHMT2 and its catalyzed histone modifications H3K9me1 and H3K9me2 during maturation of central auditory system.
Topics: Animals; Animals, Newborn; Auditory Cortex; Auditory Pathways; Biocatalysis; Brain Stem; Down-Regulation; Hearing; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Mice, Inbred C57BL; Neocortex; Neurons | 2016 |
Dynamic and flexible H3K9me3 bridging via HP1β dimerization establishes a plastic state of condensed chromatin.
Topics: Amino Acid Sequence; Blotting, Western; Cell Line, Tumor; Chromatin; Chromobox Protein Homolog 5; Chromosomal Proteins, Non-Histone; Crystallography, X-Ray; Heterochromatin; Histones; Humans; Kinetics; Lysine; Methylation; Microscopy, Fluorescence; Models, Molecular; Molecular Sequence Data; Nucleosomes; Protein Binding; Protein Multimerization; Sequence Homology, Amino Acid; Static Electricity | 2016 |
Specificity of the SUV4-20H1 and SUV4-20H2 protein lysine methyltransferases and methylation of novel substrates.
Topics: Cell Line; HEK293 Cells; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation | 2016 |
Engineering of Methylation State Specific 3xMBT Domain Using ELISA Screening.
Topics: Amino Acid Sequence; Biological Assay; Chromosomal Proteins, Non-Histone; Enzyme-Linked Immunosorbent Assay; Escherichia coli; Gene Expression; Humans; Lysine; Maltose-Binding Proteins; Methylation; Models, Molecular; Peptides; Protein Domains; Protein Engineering; Protein Processing, Post-Translational; Recombinant Proteins; Repressor Proteins; Small Molecule Libraries; Tumor Suppressor Proteins | 2016 |
Epigenetic profiles signify cell fate plasticity in unipotent spermatogonial stem and progenitor cells.
Topics: Animals; Cell Differentiation; Cell Plasticity; Cells, Cultured; Embryonic Stem Cells; Epigenomics; Gene Expression Profiling; Histones; Lysine; Male; Methylation; Mice, 129 Strain; Mice, Inbred C57BL; Mice, Transgenic; Multipotent Stem Cells; Spermatogenesis; Spermatogonia | 2016 |
Structural basis of oncogenic histone H3K27M inhibition of human polycomb repressive complex 2.
Topics: Brain Neoplasms; Carcinogenesis; Catalytic Domain; Crystallography, X-Ray; Enhancer of Zeste Homolog 2 Protein; Histones; Humans; Lysine; Methylation; Models, Molecular; Mutation; Oncogenes; Polycomb Repressive Complex 2; Protein Binding; Protein Domains | 2016 |
Targeting EZH2-mediated methylation of H3K27 inhibits proliferation and migration of Synovial Sarcoma in vitro.
Topics: Cell Line, Tumor; Cell Movement; Cell Proliferation; Enhancer of Zeste Homolog 2 Protein; Gene Knockdown Techniques; Histones; Humans; Lysine; Methylation; Protein Processing, Post-Translational; Sarcoma, Synovial | 2016 |
The EZH1-SUZ12 complex positively regulates the transcription of NF-κB target genes through interaction with UXT.
Topics: Apoptosis; Cell Cycle Proteins; Cell Nucleus; Gene Expression Regulation; HCT116 Cells; Histones; Humans; Lysine; Methylation; Molecular Chaperones; Neoplasm Proteins; NF-kappa B; Polycomb Repressive Complex 2; Protein Binding; Protein Transport; RNA Polymerase II; Transcription Factor RelA; Transcription Factors; Transcription, Genetic; Tumor Necrosis Factor-alpha | 2016 |
Multifaceted Histone H3 Methylation and Phosphorylation Readout by the Plant Homeodomain Finger of Human Nuclear Antigen Sp100C.
Topics: Amino Acid Sequence; Antigens, Nuclear; Autoantigens; Binding Sites; Calorimetry; Crystallography, X-Ray; HeLa Cells; Histones; Humans; Hydrogen Bonding; Lysine; Methylation; Microscopy, Confocal; Models, Molecular; Mutation; Phosphorylation; Protein Binding; Protein Domains; Protein Isoforms; Sequence Homology, Amino Acid | 2016 |
Methylation of histone H4 lysine 20 by PR-Set7 ensures the integrity of late replicating sequence domains in Drosophila.
Topics: Animals; Cell Cycle Checkpoints; Cell Cycle Proteins; Cell Line; DNA Damage; DNA Replication; DNA Replication Timing; Drosophila melanogaster; Drosophila Proteins; Genome, Insect; Genomic Instability; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Protein Serine-Threonine Kinases; Replication Origin; S Phase | 2016 |
Multi-layered Regulation of SPL15 and Cooperation with SOC1 Integrate Endogenous Flowering Pathways at the Arabidopsis Shoot Meristem.
Topics: Amino Acid Sequence; Arabidopsis; Arabidopsis Proteins; Base Sequence; Flowers; Gibberellins; Histones; Lysine; MADS Domain Proteins; Mediator Complex; Meristem; Methylation; Models, Biological; Protein Binding; Time Factors; Transcription Factors; Transcriptional Activation | 2016 |
Setd1a and NURF mediate chromatin dynamics and gene regulation during erythroid lineage commitment and differentiation.
Topics: Animals; Antigens, Nuclear; Cell Lineage; Cells, Cultured; Chromatin; Chromatin Assembly and Disassembly; Chromatin Immunoprecipitation; Erythroblasts; Erythrocyte Count; Erythrocytes; Erythropoiesis; Female; Gene Expression Regulation; Hemoglobins; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Male; Methylation; Mice; Mice, Knockout; Micrococcal Nuclease; Multiprotein Complexes; Nerve Tissue Proteins; Promoter Regions, Genetic; Spleen; Transcription Factors; Upstream Stimulatory Factors | 2016 |
ASH1L Links Histone H3 Lysine 36 Dimethylation to MLL Leukemia.
Topics: Animals; Cell Line; Cell Transformation, Neoplastic; Chromatin Immunoprecipitation; Disease Models, Animal; DNA-Binding Proteins; F-Box Proteins; Female; Gene Expression Regulation, Leukemic; Heterografts; High-Throughput Nucleotide Sequencing; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; Intercellular Signaling Peptides and Proteins; Jumonji Domain-Containing Histone Demethylases; Leukemia; Lysine; Methylation; Mice; Myeloid-Lymphoid Leukemia Protein; Nucleosomes; Promoter Regions, Genetic; Protein Binding; Transcription Factors | 2016 |
Homeobox genes gain trimethylation of histone H3 lysine 4 in glioblastoma tissue.
Topics: Brain Neoplasms; Cadherins; Chromatin Immunoprecipitation; DNA Methylation; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Genes, Homeobox; Glioblastoma; Histones; Humans; Lysine; Methylation; Middle Aged; Promoter Regions, Genetic | 2016 |
Identification of Novel EZH2 Targets Regulating Osteogenic Differentiation in Mesenchymal Stem Cells.
Topics: Adult; Cell Differentiation; Chromatin Immunoprecipitation; Enhancer of Zeste Homolog 2 Protein; Gene Knockdown Techniques; Histones; Humans; Intracellular Signaling Peptides and Proteins; LIM Domain Proteins; Lysine; Mesenchymal Stem Cells; Methylation; Muscle Proteins; Myxovirus Resistance Proteins; Osteoblasts; Osteogenesis; Real-Time Polymerase Chain Reaction; Repressor Proteins; RNA, Small Interfering; Up-Regulation | 2016 |
Development of a DNA-Templated Peptide Probe for Photoaffinity Labeling and Enrichment of the Histone Modification Reader Proteins.
Topics: DNA; HeLa Cells; Histone Code; Histones; Humans; Lysine; Methylation; Peptides; Photoaffinity Labels; Photochemical Processes; Protein Processing, Post-Translational; Proteomics | 2016 |
Histone H3K36 mutations promote sarcomagenesis through altered histone methylation landscape.
Topics: Animals; Bone Neoplasms; Carcinogenesis; Child, Preschool; Chondroblastoma; Gene Expression Regulation, Neoplastic; Histones; Humans; Lysine; Mesenchymal Stem Cells; Methionine; Methylation; Methyltransferases; Mice; Mutation; Mutation, Missense; Neoplastic Stem Cells; Nucleosomes; Polycomb Repressive Complex 1; Sarcoma | 2016 |
The Polycomb group protein CLF emerges as a specific tri-methylase of H3K27 regulating gene expression and development in Physcomitrella patens.
Topics: Amino Acid Sequence; Bryopsida; Gene Expression Regulation, Developmental; Gene Expression Regulation, Plant; Genes, Plant; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Homeodomain Proteins; Lysine; Methylation; Molecular Sequence Data; Plant Leaves; Plants, Genetically Modified; Polycomb-Group Proteins; Sequence Homology, Amino Acid | 2016 |
G9a promotes proliferation and inhibits cell cycle exit during myogenic differentiation.
Topics: Animals; Cell Cycle; Cell Differentiation; Cell Line; Cell Proliferation; E2F1 Transcription Factor; Gene Expression Regulation; Gene Knockdown Techniques; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Mice, Inbred C57BL; Muscle Development; Myoblasts; MyoD Protein; p300-CBP Transcription Factors; Promoter Regions, Genetic | 2016 |
The histone H3.3K36M mutation reprograms the epigenome of chondroblastomas.
Topics: Amino Acid Substitution; Bone Neoplasms; Carcinogenesis; Chondroblastoma; Epigenesis, Genetic; Genes, Neoplasm; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Mutation; Repressor Proteins | 2016 |
The HIV-1 Tat Protein Is Monomethylated at Lysine 71 by the Lysine Methyltransferase KMT7.
Topics: Histone-Lysine N-Methyltransferase; HIV-1; Humans; Jurkat Cells; Lysine; Methylation; tat Gene Products, Human Immunodeficiency Virus; Transcriptional Activation | 2016 |
Computational prediction of methylation types of covalently modified lysine and arginine residues in proteins.
Topics: Arginine; Lysine; Methylation; Protein Processing, Post-Translational; Proteins | 2017 |
ZFP57 maintains the parent-of-origin-specific expression of the imprinted genes and differentially affects non-imprinted targets in mouse embryonic stem cells.
Topics: Animals; Binding Sites; Cell Differentiation; CpG Islands; Epigenesis, Genetic; Gene Expression Regulation, Developmental; Genetic Loci; Genomic Imprinting; Histones; Lysine; Methylation; Mice; Models, Genetic; Mouse Embryonic Stem Cells; Nuclear Proteins; Repressor Proteins | 2016 |
Mechanisms of histone lysine-modifying enzymes: A computational perspective on the role of the protein environment.
Topics: Acetylation; Catalytic Domain; Demethylation; Enzymes; Epigenesis, Genetic; Histone Deacetylases; Histones; Lysine; Methylation; Models, Molecular; Sirtuins; Substrate Specificity | 2016 |
Selective inhibition of EZH2 by ZLD10A blocks H3K27 methylation and kills mutant lymphoma cells proliferation.
Topics: Apoptosis; Benzamides; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Cell Shape; Enhancer of Zeste Homolog 2 Protein; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; Isoquinolines; Lymphoma; Lysine; Methylation; Mutation | 2016 |
KAT7/HBO1/MYST2 Regulates CENP-A Chromatin Assembly by Antagonizing Suv39h1-Mediated Centromere Inactivation.
Topics: Autoantigens; Centromere; Centromere Protein A; Chromatin Assembly and Disassembly; Chromosomal Proteins, Non-Histone; Chromosome Segregation; DNA-Binding Proteins; G1 Phase; Gene Knockout Techniques; HeLa Cells; Histone Acetyltransferases; Histones; Humans; Lysine; Methylation; Methyltransferases; Multiprotein Complexes; Nuclear Proteins; Protein Stability; Protein Subunits; Repressor Proteins; Trans-Activators | 2016 |
Lysine demethylase KDM3A regulates breast cancer cell invasion and apoptosis by targeting histone and the non-histone protein p53.
Topics: Animals; Antineoplastic Agents; Apoptosis; Apoptosis Regulatory Proteins; Breast Neoplasms; Cell Line, Tumor; Cell Movement; Disease Models, Animal; Drug Resistance, Neoplasm; Epigenesis, Genetic; Female; Gene Expression; Gene Knockdown Techniques; Histones; Humans; Jumonji Domain-Containing Histone Demethylases; Lysine; Methylation; Mice; Mutation; Neoplastic Stem Cells; Promoter Regions, Genetic; Protein Binding; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-bcl-2; Tumor Suppressor Protein p53 | 2017 |
Transcription factors AS1 and AS2 interact with LHP1 to repress KNOX genes in Arabidopsis.
Topics: Arabidopsis; Arabidopsis Proteins; Biocatalysis; Epistasis, Genetic; Gene Expression Regulation, Plant; Genes, Plant; Genetic Loci; Histones; Homeodomain Proteins; Lysine; Methylation; Phenotype; Plant Leaves; Protein Binding; Repressor Proteins; Reproducibility of Results; RNA, Messenger; Transcription Factors | 2016 |
Arabidopsis RNA Polymerases IV and V Are Required To Establish H3K9 Methylation, but Not Cytosine Methylation, on Geminivirus Chromatin.
Topics: Arabidopsis; Arabidopsis Proteins; Chromatin; Cytosine; DNA-Directed RNA Polymerases; DNA, Viral; Geminiviridae; Histones; Lysine; Methylation | 2016 |
PI3K/AKT Signaling Regulates H3K4 Methylation in Breast Cancer.
Topics: Amino Acid Sequence; Animals; Breast Neoplasms; Cell Cycle; Enzyme Activation; Female; Gene Expression Regulation, Neoplastic; Histones; Humans; Lysine; Methylation; Mice; Models, Biological; Phosphatidylinositol 3-Kinases; Promoter Regions, Genetic; Protein Transport; Proto-Oncogene Proteins c-akt; Retinoblastoma-Binding Protein 2; Subcellular Fractions; Substrate Specificity; Treatment Outcome | 2016 |
MOF Acetylates the Histone Demethylase LSD1 to Suppress Epithelial-to-Mesenchymal Transition.
Topics: Acetylation; Cadherins; Cell Line, Tumor; Disease Progression; Down-Regulation; Embryo, Mammalian; Epithelial Cells; Epithelial-Mesenchymal Transition; Fibroblasts; Gene Expression Regulation, Neoplastic; Histone Acetyltransferases; Histone Demethylases; Histones; Humans; Lysine; Methylation; Multiprotein Complexes; Mutation; Neoplasm Invasiveness; Neoplasm Metastasis; Nucleosomes | 2016 |
Protein Abundance Control by Non-coding Antisense Transcription.
Topics: Base Sequence; Gene Expression Regulation, Fungal; Gene Library; Histones; Lysine; Methylation; Microscopy; Proteins; Reproducibility of Results; RNA, Antisense; RNA, Fungal; RNA, Untranslated; Saccharomyces cerevisiae; Transcription Initiation Site; Transcription, Genetic | 2016 |
SET9-Mediated Regulation of TGF-β Signaling Links Protein Methylation to Pulmonary Fibrosis.
Topics: Acetylation; Animals; Bleomycin; Extracellular Matrix; Gene Expression Regulation; HeLa Cells; Histone-Lysine N-Methyltransferase; Humans; Lysine; Male; Methylation; Mice, Inbred C57BL; Mice, Knockout; Models, Biological; Nuclear Proteins; Protein Methyltransferases; Protein Stability; Pulmonary Fibrosis; Signal Transduction; Smad7 Protein; Transforming Growth Factor beta; Ubiquitin-Protein Ligases; Ubiquitination | 2016 |
EZH2 phosphorylation by JAK3 mediates a switch to noncanonical function in natural killer/T-cell lymphoma.
Topics: Cell Line, Tumor; Cell Proliferation; Enhancer of Zeste Homolog 2 Protein; Enzyme Activation; Gene Expression Regulation, Neoplastic; Histones; Humans; Janus Kinase 3; Lymphoma, T-Cell; Lysine; Methylation; Models, Biological; Natural Killer T-Cells; Neoplasm Proteins; Phosphorylation; Phosphotyrosine; Polycomb Repressive Complex 2; Protein Binding; Protein Kinase Inhibitors; Protein Subunits; RNA Polymerase II; Transcription Factors | 2016 |
sPLA2 -IIA Overexpression in Mice Epidermis Depletes Hair Follicle Stem Cells and Induces Differentiation Mediated Through Enhanced JNK/c-Jun Activation.
Topics: Aging; Animals; Cell Differentiation; Cell Proliferation; Enzyme Activation; Epidermis; ErbB Receptors; Gene Expression Profiling; Group II Phospholipases A2; Hair Follicle; Histones; Homeostasis; Hyperplasia; JNK Mitogen-Activated Protein Kinases; Keratinocytes; Lysine; Methylation; Mice, Transgenic; Parakeratosis; Proto-Oncogene Proteins c-jun; Sebaceous Glands; Signal Transduction; Stem Cells | 2016 |
Systems Level Analysis of Histone H3 Post-translational Modifications (PTMs) Reveals Features of PTM Crosstalk in Chromatin Regulation.
Topics: Animals; Arginine; Chromatin; Chromatography, Liquid; Gene Knockout Techniques; Histones; Lysine; Methylation; Mice; Mouse Embryonic Stem Cells; Polycomb Repressive Complex 1; Polycomb Repressive Complex 2; Protein Processing, Post-Translational; Proteomics; Tandem Mass Spectrometry | 2016 |
Correspondence: On the enzymology and significance of HSPA1 lysine methylation.
Topics: Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Molecular Chaperones; Protein Processing, Post-Translational | 2016 |
Direct aqueous synthesis of cyanomethyl thioglycosides from reducing sugars; ready access to reagents for protein glycosylation.
Topics: Animals; Chickens; Glycosylation; Halogenation; Indicators and Reagents; Lysine; Methylation; Models, Molecular; Muramidase; Nitriles; Oligosaccharides; Oxidation-Reduction; Proteins; Thioglycosides | 2016 |
aKMT Catalyzes Extensive Protein Lysine Methylation in the Hyperthermophilic Archaeon Sulfolobus islandicus but is Dispensable for the Growth of the Organism.
Topics: Archaeal Proteins; Crystallography, X-Ray; Gene Deletion; Gene Expression Regulation, Archaeal; Lysine; Mass Spectrometry; Methylation; Models, Molecular; Protein Methyltransferases; Protein Structure, Secondary; Proteomics; S-Adenosylhomocysteine; S-Adenosylmethionine; Sulfolobus | 2016 |
DOT1L as a therapeutic target for the treatment of DNMT3A-mutant acute myeloid leukemia.
Topics: Adenosine; Animals; Apoptosis; Cell Cycle Checkpoints; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; DNA (Cytosine-5-)-Methyltransferases; DNA Methyltransferase 3A; Gene Expression Regulation, Leukemic; Hematopoietic Stem Cells; Histone-Lysine N-Methyltransferase; Histones; Humans; Leukemia, Myeloid, Acute; Lysine; Methylation; Methyltransferases; Mice, Inbred C57BL; Molecular Targeted Therapy; Mutation; Phenylurea Compounds; Rats; Time Factors; Tumor Stem Cell Assay; Xenograft Model Antitumor Assays | 2016 |
H4K20me0 marks post-replicative chromatin and recruits the TONSL–MMS22L DNA repair complex.
Topics: Chromatin; DNA Repair; DNA Replication; DNA-Binding Proteins; Genomic Instability; Histones; Homologous Recombination; Humans; Lysine; Methylation; Models, Molecular; Molecular Chaperones; NF-kappa B; Nuclear Proteins; Protein Binding; Protein Structure, Tertiary | 2016 |
Dynamic regulation of histone H3K9 is linked to the switch between replication and transcription at the Dbf4 origin-promoter locus.
Topics: Acetylation; Cell Cycle; Cell Cycle Proteins; Chromatin; Chromobox Protein Homolog 5; Chromosomal Proteins, Non-Histone; Cohesins; DNA Replication; Down-Regulation; Genetic Loci; HEK293 Cells; HeLa Cells; Histones; Humans; Jumonji Domain-Containing Histone Demethylases; Lysine; Mediator Complex; Methylation; Nucleosomes; Promoter Regions, Genetic; Protein Binding; Protein Processing, Post-Translational; Pseudogenes; Replication Origin; Transcription, Genetic | 2016 |
The H3K9 methyltransferase Setdb1 regulates TLR4-mediated inflammatory responses in macrophages.
Topics: Animals; Cell Line; Cells, Cultured; Cytokines; Gene Expression Profiling; Histone-Lysine N-Methyltransferase; Histones; Inflammation Mediators; Interleukin-6; Lysine; Macrophages; Methylation; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; NF-kappa B; RNA Interference; Toll-Like Receptor 4 | 2016 |
TRIM28 is an Epigenetic Barrier to Induced Pluripotent Stem Cell Reprogramming.
Topics: Animals; Cell Proliferation; Cellular Reprogramming; Chromatin; Endogenous Retroviruses; Epigenesis, Genetic; Gene Knockdown Techniques; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Mice, Transgenic; Models, Biological; Pluripotent Stem Cells; RNA, Small Interfering; Tripartite Motif-Containing Protein 28; Up-Regulation | 2017 |
Histone Methylation by Temozolomide; A Classic DNA Methylating Anticancer Drug.
Topics: Animals; Antineoplastic Agents, Alkylating; Arginine; Dacarbazine; DNA Methylation; Histones; Humans; Lysine; Mass Spectrometry; Methylation; Temozolomide; Xenopus | 2016 |
Accurate in silico prediction of species-specific methylation sites based on information gain feature optimization.
Topics: Animals; Computer Simulation; Humans; Lysine; Methylation; Protein Processing, Post-Translational; Species Specificity | 2016 |
Intrinsic protein disorder in histone lysine methylation.
Topics: Binding Sites; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation | 2016 |
Phosphoproteomic analysis of Methanohalophilus portucalensis FDF1(T) identified the role of protein phosphorylation in methanogenesis and osmoregulation.
Topics: Amino Acid Sequence; Archaeal Proteins; Betaine; Global Warming; Glycine N-Methyltransferase; Lysine; Methane; Methanosarcinaceae; Methylation; Models, Molecular; Mutation, Missense; Osmoregulation; Phosphoproteins; Phosphorylation; Point Mutation; Protein Conformation; Protein Processing, Post-Translational; Proteomics; Salt Tolerance; Tandem Mass Spectrometry | 2016 |
An Achilles' Heel for MLL-Rearranged Leukemias: Writers and Readers of H3 Lysine 36 Dimethylation.
Topics: DNA-Binding Proteins; Epigenesis, Genetic; Gene Expression Regulation, Leukemic; Hematopoiesis; Histone-Lysine N-Methyltransferase; Histones; Humans; Leukemia; Lysine; Methylation; Myeloid-Lymphoid Leukemia Protein; Transcription Factors; Translocation, Genetic | 2016 |
Preparation, Biochemical Analysis, and Structure Determination of Methyllysine Readers.
Topics: Animals; Crystallography, X-Ray; Epigenesis, Genetic; Escherichia coli; Glutathione Transferase; Histone Code; Histones; Humans; Lysine; Methylation; Nuclear Magnetic Resonance, Biomolecular; Plasmids; Protein Domains; Protein Processing, Post-Translational; Recombinant Fusion Proteins; Up-Regulation | 2016 |
Cardiolipin binds selectively but transiently to conserved lysine residues in the rotor of metazoan ATP synthases.
Topics: Amino Acid Sequence; Animals; Bacterial Proteins; Binding Sites; Cardiolipins; Cattle; Lipid Bilayers; Lysine; Methylation; Molecular Dynamics Simulation; Protein Binding; Proton-Translocating ATPases; Saccharomyces cerevisiae Proteins; Sequence Homology, Amino Acid | 2016 |
Supramolecular Affinity Labeling of Histone Peptides Containing Trimethyllysine and Its Application to Histone Deacetylase Assays.
Topics: Amino Acid Sequence; Enzyme Assays; Fluorescent Dyes; Histone Deacetylases; Histones; Lysine; Methylation; Protein Processing, Post-Translational | 2016 |
TALE-directed local modulation of H3K9 methylation shapes exon recognition.
Topics: Alternative Splicing; Chromatin; Exons; Fibronectins; HeLa Cells; Histones; Humans; Lysine; Methylation; Transcription Activator-Like Effectors; Transcription, Genetic | 2016 |
Evidence for Regulation of ECM3 Expression by Methylation of Histone H3 Lysine 4 and Intergenic Transcription in Saccharomyces cerevisiae.
Topics: Adenosine Triphosphatases; Chromatin; DNA-Binding Proteins; Gene Expression Regulation, Fungal; Histones; Lysine; Methylation; Nuclear Proteins; Nucleosomes; Promoter Regions, Genetic; RNA, Untranslated; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Transcription, Genetic | 2016 |
The Structure and Catalytic Mechanism of Sorghum bicolor Caffeoyl-CoA O-Methyltransferase.
Topics: Acyl Coenzyme A; Amino Acid Sequence; Biocatalysis; Calcium; Catalytic Domain; Crystallography, X-Ray; Electrophoresis, Polyacrylamide Gel; Kinetics; Lysine; Methylation; Methyltransferases; Models, Molecular; Mutation; Plant Proteins; Protein Multimerization; Protein Structure, Tertiary; Sequence Homology, Amino Acid; Sorghum; Substrate Specificity; Thermodynamics | 2016 |
Beneficial effects of diazepin-quinazolin-amine derivative (BIX-01294) on preimplantation development and molecular characteristics of cloned mouse embryos.
Topics: Animals; Azepines; Blastocyst; Cloning, Organism; CpG Islands; DNA Methylation; Ectogenesis; Embryo, Mammalian; Enzyme Inhibitors; Epigenesis, Genetic; Female; Gene Expression Regulation, Developmental; GRB10 Adaptor Protein; Histone-Lysine N-Methyltransferase; Histones; Lysine; Male; Methylation; Mice; Nuclear Transfer Techniques; Parthenogenesis; Protein Processing, Post-Translational; Quinazolines | 2017 |
H3K27me3 Does Not Orchestrate the Expression of Lineage-Specific Markers in hESC-Derived Hepatocytes In Vitro.
Topics: Biomarkers; Cell Differentiation; Cell Lineage; Dimethyl Sulfoxide; Enhancer of Zeste Homolog 2 Protein; Gene Expression Regulation; Hepatocytes; Histones; Human Embryonic Stem Cells; Humans; Lysine; Methylation; Regulatory Sequences, Nucleic Acid; Transcription, Genetic | 2016 |
Epigenetic modulation on cat-cow interspecies somatic cell nuclear transfer embryos by treatment with trichostatin A.
Topics: Acetylation; Animals; Cats; Cattle; Cellular Reprogramming Techniques; Embryonic Development; Epigenesis, Genetic; Female; Fertilization in Vitro; Histones; Hydroxamic Acids; Lysine; Methylation; Nuclear Transfer Techniques; Species Specificity | 2017 |
A Histone Methyltransferase ESET Is Critical for T Cell Development.
Topics: Animals; Apoptosis; CD8-Positive T-Lymphocytes; Cell Differentiation; Embryonic Stem Cells; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation; Genome; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Mice; Promoter Regions, Genetic; Receptors, IgG; Thymocytes | 2016 |
KDM5A controls bone morphogenic protein 2-induced osteogenic differentiation of bone mesenchymal stem cells during osteoporosis.
Topics: Aged; Animals; Bone and Bones; Bone Morphogenetic Protein 2; Cell Differentiation; Core Binding Factor Alpha 1 Subunit; Female; Gene Knockdown Techniques; Histones; Humans; Lysine; Mesenchymal Stem Cells; Methylation; Mice; Mice, Inbred C57BL; Osteogenesis; Osteoporosis; Ovariectomy; Promoter Regions, Genetic; Retinoblastoma-Binding Protein 2 | 2016 |
Dual Chromatin and Cytoskeletal Remodeling by SETD2.
Topics: Cell Line, Tumor; Chromatin Assembly and Disassembly; Cytokinesis; Cytoskeleton; Genomic Instability; Histone Code; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Microtubules; Mitosis; Protein Processing, Post-Translational; Tubulin | 2016 |
Mouse MORC3 is a GHKL ATPase that localizes to H3K4me3 marked chromatin.
Topics: Adenosine Triphosphatases; Adenylyl Imidodiphosphate; Animals; Chromatin; Crystallography, X-Ray; DNA-Binding Proteins; Histones; Lysine; Methylation; Mice; Models, Molecular; Promoter Regions, Genetic; Protein Binding; Protein Domains; Protein Multimerization; Zinc Fingers | 2016 |
A New Chromatin-Cytoskeleton Link in Cancer.
Topics: Chromatin; Cytoskeleton; Genomic Instability; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Mutation; Neoplasm Invasiveness; Neoplasm Metastasis; Neoplasms; Tubulin | 2016 |
Measurement of Histone Methylation Dynamics by One-Carbon Metabolic Isotope Labeling and High-energy Collisional Dissociation Methylation Signature Ion Detection.
Topics: Carbon; Cell Differentiation; Cell Proliferation; Histones; Humans; Isotope Labeling; Lysine; Methylation; Tandem Mass Spectrometry; U937 Cells | 2016 |
reChIP-seq reveals widespread bivalency of H3K4me3 and H3K27me3 in CD4(+) memory T cells.
Topics: Base Sequence; CD4-Positive T-Lymphocytes; Chromatin Immunoprecipitation; CpG Islands; DNA Methylation; Epigenesis, Genetic; Genome, Human; Histones; Humans; Lysine; Methylation; Models, Genetic; Promoter Regions, Genetic; Sequence Analysis, DNA; Transcription Initiation Site | 2016 |
Cooperation between the H3K27me3 Chromatin Mark and Non-CG Methylation in Epigenetic Regulation.
Topics: Chromatin; DNA Methylation; Epigenesis, Genetic; Gene Expression Profiling; Gene Expression Regulation, Developmental; Gene Expression Regulation, Plant; Histones; Lysine; Meristem; Methylation; Mutation; Oryza; Plant Leaves; Plant Proteins; Plant Shoots; Polycomb Repressive Complex 2; Protein Binding; Reverse Transcriptase Polymerase Chain Reaction | 2016 |
Lysine methylation represses p53 activity in teratocarcinoma cancer cells.
Topics: Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Gene Expression Regulation, Neoplastic; Histone-Lysine N-Methyltransferase; Humans; Lysine; Male; Methylation; Protein Domains; Protein Processing, Post-Translational; RNA, Small Interfering; Signal Transduction; Teratocarcinoma; Testicular Neoplasms; Tumor Suppressor Protein p53 | 2016 |
Dissecting the precise role of H3K9 methylation in crosstalk with DNA maintenance methylation in mammals.
Topics: Animals; Animals, Newborn; CCAAT-Enhancer-Binding Proteins; CpG Islands; DNA; DNA Methylation; Histones; Lysine; Mammals; Methylation; Mice, Inbred C57BL; Mice, Transgenic; Nuclear Proteins; Nucleosomes; Protein Binding; Ubiquitin-Protein Ligases | 2016 |
Abundant Lysine Methylation and N-Terminal Acetylation in Sulfolobus islandicus Revealed by Bottom-Up and Top-Down Proteomics.
Topics: Acetylation; Archaeal Proteins; Chromatin; Chromatography, Liquid; Lysine; Methylation; Protein Processing, Post-Translational; Proteomics; Sulfolobus; Tandem Mass Spectrometry | 2016 |
Interdependence of PRC1 and PRC2 for recruitment to Polycomb Response Elements.
Topics: Animals; Animals, Genetically Modified; Chromatin; Drosophila Proteins; Genome, Insect; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Microtubule-Associated Proteins; Polycomb Repressive Complex 1; Polycomb-Group Proteins; Response Elements; Ubiquitination | 2016 |
SETDB2 Links Glucocorticoid to Lipid Metabolism through Insig2a Regulation.
Topics: Animals; Chromatin; Dexamethasone; Enhancer Elements, Genetic; Feeding Behavior; Gene Expression Regulation; Gene Knockdown Techniques; Genetic Loci; Glucocorticoids; Histone-Lysine N-Methyltransferase; Histones; Lipid Metabolism; Liver; Lysine; Male; Membrane Proteins; Methylation; Mice, Inbred C57BL; Mice, Obese; Promoter Regions, Genetic; Protein Binding; Receptors, Glucocorticoid; RNA, Messenger; Sterol Regulatory Element Binding Protein 1; Transcription, Genetic | 2016 |
Polycomb Repressive Complex 2 Enacts Wnt Signaling in Intestinal Homeostasis and Contributes to the Instigation of Stemness in Diseases Entailing Epithelial Hyperplasia or Neoplasia.
Topics: Animals; Celiac Disease; Cell Differentiation; Cell Proliferation; Enterocytes; Gene Expression Regulation, Neoplastic; Glutens; Histones; Homeostasis; Humans; Hyperplasia; Intestinal Mucosa; Intestinal Neoplasms; Lysine; Methylation; Mice, Inbred C57BL; Models, Biological; Polycomb Repressive Complex 2; Stem Cell Niche; Stem Cells; Wnt Signaling Pathway | 2017 |
Zinc oxide nanoparticles-induced epigenetic change and G2/M arrest are associated with apoptosis in human epidermal keratinocytes.
Topics: Acetylation; Apoptosis; Cell Line; Cell Proliferation; Cell Survival; Chromatin; DNA Damage; Epidermal Cells; Epigenesis, Genetic; G2 Phase Cell Cycle Checkpoints; Histones; Humans; Keratinocytes; Lysine; M Phase Cell Cycle Checkpoints; Methylation; Models, Biological; Nanoparticles; Reactive Oxygen Species; Signal Transduction; Up-Regulation; Zinc Oxide | 2016 |
Preovulatory Aging In Vivo and In Vitro Affects Maturation Rates, Abundance of Selected Proteins, Histone Methylation Pattern and Spindle Integrity in Murine Oocytes.
Topics: Aging; Animals; Chromosomes, Mammalian; Histones; Lysine; Metaphase; Methylation; Mice; Oocytes; Ovulation; RNA-Binding Proteins; RNA, Messenger; Spindle Apparatus | 2016 |
Broad histone H3K4me3 domains in mouse oocytes modulate maternal-to-zygotic transition.
Topics: Acetylation; Animals; Cell Line, Tumor; Chromatin; Chromatin Immunoprecipitation; DNA Methylation; Embryonic Development; Female; Gene Expression Regulation, Developmental; Genome; Histones; Humans; Lysine; Male; Methylation; Mice; Oocytes; Sequence Analysis, DNA; Transcription Initiation Site; Zygote | 2016 |
Distinct features of H3K4me3 and H3K27me3 chromatin domains in pre-implantation embryos.
Topics: Animals; Blastocyst; Chromatin; Chromatin Immunoprecipitation; Embryonic Stem Cells; Epigenesis, Genetic; Female; Fertilization; Genome; Histones; Lysine; Male; Methylation; Mice; Promoter Regions, Genetic; Transcription Initiation Site; Zygote | 2016 |
Allelic reprogramming of the histone modification H3K4me3 in early mammalian development.
Topics: Alleles; Animals; Cellular Reprogramming; Chromatin Immunoprecipitation; CpG Islands; DNA Methylation; DNA Replication; DNA-Binding Proteins; Embryo, Mammalian; Female; Fertilization; Gene Silencing; Genome; Histones; Jumonji Domain-Containing Histone Demethylases; Lysine; Male; Methylation; Mice; Oocytes; Promoter Regions, Genetic; Sequence Analysis, DNA; Transcription Initiation, Genetic; Zygote | 2016 |
Aging Triggers a Repressive Chromatin State at Bdnf Promoters in Hippocampal Neurons.
Topics: Acetylation; Aging; Animals; Brain-Derived Neurotrophic Factor; Cholesterol; Chromatin; Cognition; Epigenesis, Genetic; Hippocampus; Histones; Long-Term Potentiation; Lysine; Methylation; Mice, Inbred C57BL; N-Methylaspartate; Neurons; Promoter Regions, Genetic; Receptors, N-Methyl-D-Aspartate; Signal Transduction; Transcription, Genetic; Voriconazole | 2016 |
SMYD3-mediated lysine methylation in the PH domain is critical for activation of AKT1.
Topics: Cell Membrane; Enzyme Activation; Gene Expression; Gene Knockdown Techniques; Histone-Lysine N-Methyltransferase; Humans; Lysine; Methylation; Neoplasms; Phosphorylation; Pleckstrin Homology Domains; Proto-Oncogene Proteins c-akt; Signal Transduction; Tyrosine | 2016 |
Genome-wide positioning of bivalent mononucleosomes.
Topics: Cell Line, Tumor; CpG Islands; Epigenesis, Genetic; Genomics; Histones; Humans; Lysine; Methylation; Nucleosomes; Promoter Regions, Genetic; Transcription Initiation Site | 2016 |
Histone Modifications Define Expression Bias of Homoeologous Genomes in Allotetraploid Cotton.
Topics: Cell Nucleus; Chromosomes, Plant; DNA, Ribosomal; Gene Expression Profiling; Gene Expression Regulation, Plant; Genes, Plant; Genetic Loci; Genome, Plant; Gossypium; Histone Code; Histones; Lysine; Meristem; Methylation; Polyploidy; Protein Processing, Post-Translational; RNA, Messenger; Translocation, Genetic | 2016 |
Differential deposition of H2A.Z in combination with histone modifications within related genes in Oryza sativa callus and seedling.
Topics: Chromatin Immunoprecipitation; Chromosome Mapping; DNA Methylation; Gene Expression Regulation, Plant; Histone Code; Histones; Lysine; Methylation; Oryza; Plant Proteins; Seedlings; Transcription Initiation Site | 2017 |
Dpy30 is critical for maintaining the identity and function of adult hematopoietic stem cells.
Topics: Adult Stem Cells; Animals; Bone Marrow; Cell Differentiation; Cell Lineage; Down-Regulation; Gene Deletion; Genome; Hematopoiesis; Hematopoietic Stem Cell Transplantation; Hematopoietic Stem Cells; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Mice, Inbred C57BL; Mice, Knockout; Pancytopenia; Phenotype; Signal Transduction; Transcription Factors | 2016 |
Involvement of Histone Lysine Methylation in p21 Gene Expression in Rat Kidney In Vivo and Rat Mesangial Cells In Vitro under Diabetic Conditions.
Topics: Animals; Antibodies; Blotting, Western; Cyclin-Dependent Kinase Inhibitor p21; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Gene Expression Regulation; Glucose; Histone Code; Histone-Lysine N-Methyltransferase; In Vitro Techniques; Kidney Glomerulus; Lysine; Male; Mesangial Cells; Methylation; Promoter Regions, Genetic; Rats; Rats, Wistar; Transforming Growth Factor beta1 | 2016 |
Insights into the epigenetic mechanisms involving histone lysine methylation and demethylation in ischemia induced damage and repair has therapeutic implication.
Topics: Amino Acids, Dicarboxylic; Animals; Brain; Brain Ischemia; Cell Death; Corpus Striatum; Demethylation; Epigenesis, Genetic; Histone Demethylases; Histone-Lysine N-Methyltransferase; Histones; Lysine; Male; Methylation; Mice | 2017 |
Histone H3K9 methylation is dispensable for Caenorhabditis elegans development but suppresses RNA:DNA hybrid-associated repeat instability.
Topics: Animals; Caenorhabditis elegans; Caenorhabditis elegans Proteins; DNA, Helminth; Fertility; Genes, Helminth; Histone-Lysine N-Methyltransferase; Histones; Interspersed Repetitive Sequences; Lysine; Methylation; Nucleic Acid Hybridization; RNA Stability; RNA, Helminth; Temperature | 2016 |
Effect of lysine methylation and acetylation on the RNA recognition and cellular uptake of Tat-derived peptides.
Topics: Acetylation; Humans; Hydrogen Bonding; Jurkat Cells; Lysine; Methylation; Peptides; RNA, Viral; tat Gene Products, Human Immunodeficiency Virus | 2016 |
UTX-1 regulates Tat-induced HIV-1 transactivation via changing the methylated status of histone H3.
Topics: Active Transport, Cell Nucleus; Cell Nucleus; HeLa Cells; Histone Demethylases; Histones; HIV-1; Humans; Lysine; Methylation; NF-kappa B; Nuclear Proteins; tat Gene Products, Human Immunodeficiency Virus; Transcription Factor RelA; Transcriptional Activation; Up-Regulation | 2016 |
Global tRNA misacylation induced by anaerobiosis and antibiotic exposure broadly increases stress resistance in Escherichia coli.
Topics: Acylation; Adaptation, Biological; Amino Acid Sequence; Anaerobiosis; Anti-Bacterial Agents; Cluster Analysis; Escherichia coli; Lysine; Methionine; Methionine-tRNA Ligase; Methylation; Protein Biosynthesis; RNA, Transfer; Stress, Physiological | 2016 |
A-to-I RNA editing of the IGFBP7 transcript increases during aging in porcine brain tissues.
Topics: Aging; Amino Acid Sequence; Animals; Arginine; Binding Sites; Brain; Brain Mapping; Cerebellum; Chromosome Mapping; Female; Frontal Lobe; Gene Expression Profiling; Gene Expression Regulation; Humans; Insulin-Like Growth Factor Binding Proteins; Lung; Lysine; Methylation; Mice; RNA Editing; RNA-Binding Proteins; RNA, Messenger; Sulfates; Swine | 2016 |
Dietary resistant starch type 4-derived butyrate attenuates nuclear factor-kappa-B1 through modulation of histone H3 trimethylation at lysine 27.
Topics: Animals; Bacteria; Butyric Acid; Cecum; Cell Line; Dietary Carbohydrates; Gastrointestinal Microbiome; Histones; Humans; Lysine; Male; Methylation; Mice; NF-kappa B; Promoter Regions, Genetic; Starch | 2016 |
H3K36 methylation state and associated silencing mechanisms.
Topics: Epigenesis, Genetic; Exons; Gene Silencing; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Male; Methylation; Protein Domains; RNA Polymerase II | 2017 |
ATF7IP-Mediated Stabilization of the Histone Methyltransferase SETDB1 Is Essential for Heterochromatin Formation by the HUSH Complex.
Topics: Cell Nucleus; Enzyme Stability; Epigenesis, Genetic; Gene Deletion; Gene Silencing; HeLa Cells; Heterochromatin; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Multiprotein Complexes; Proteasome Endopeptidase Complex; Protein Binding; Protein Methyltransferases; Proteolysis; Repressor Proteins; Transcription Factors; Transcriptome | 2016 |
Lysyl oxidase-like 2 (LOXL2) oxidizes trimethylated lysine 4 in histone H3.
Topics: Amino Acid Oxidoreductases; Antigens, CD; Blotting, Western; Cadherins; Cell Line; Cell Line, Tumor; Gene Expression Profiling; Gene Expression Regulation; Histones; Humans; Lysine; Methylation; Oxidation-Reduction; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Spectrophotometry, Infrared | 2016 |
Elucidation of the Fanconi Anemia Protein Network in Meiosis and Its Function in the Regulation of Histone Modifications.
Topics: Adaptor Proteins, Signal Transducing; Animals; BRCA1 Protein; BRCA2 Protein; Cell Cycle Proteins; DNA Breaks, Double-Stranded; Fanconi Anemia Complementation Group Proteins; Histones; Intracellular Signaling Peptides and Proteins; Lysine; Male; Meiosis; Methylation; Mice; Protein Processing, Post-Translational; Rad51 Recombinase; Recombination, Genetic; Sex Chromosomes; Time Factors | 2016 |
PHF20 Readers Link Methylation of Histone H3K4 and p53 with H4K16 Acetylation.
Topics: Acetylation; Amino Acid Sequence; Antigens, Neoplasm; Aspartic Acid; Biomarkers, Tumor; Cell Line, Tumor; Cell Proliferation; Cell Survival; DNA-Binding Proteins; Gene Expression Regulation, Neoplastic; Glutamic Acid; Histones; Humans; Lung Neoplasms; Lysine; Methylation; Models, Biological; Models, Molecular; Mutation; Protein Binding; Protein Domains; Transcription Factors; Tumor Suppressor Protein p53 | 2016 |
Histone methyltransferase TXR1 is required for both H3 and H3.3 lysine 27 methylation in the well-known ciliated protist Tetrahymena thermophila.
Topics: Amino Acid Sequence; DNA Replication; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Mutation; Protozoan Proteins; Substrate Specificity; Tetrahymena thermophila | 2017 |
Widespread occurrence of lysine methylation in Plasmodium falciparum proteins at asexual blood stages.
Topics: Amino Acid Motifs; Amino Acid Sequence; Antibodies, Protozoan; Antibody Specificity; Histone-Lysine N-Methyltransferase; Humans; Life Cycle Stages; Lysine; Malaria, Falciparum; Methylation; Plasmodium falciparum; Position-Specific Scoring Matrices; Protozoan Proteins; Substrate Specificity | 2016 |
Roles of H3K27me2 and H3K27me3 Examined during Fate Specification of Embryonic Stem Cells.
Topics: Animals; Cell Differentiation; Cell Lineage; Embryoid Bodies; Enhancer of Zeste Homolog 2 Protein; Gene Expression Regulation; Genome; Histones; Lysine; Methylation; Mice; Mouse Embryonic Stem Cells; Neurons; Regulatory Sequences, Nucleic Acid; RNA Editing; Transcription Activator-Like Effector Nucleases; Transcription, Genetic | 2016 |
Global Proteomics Analysis of Protein Lysine Methylation.
Topics: Antibody Affinity; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Proteins; Proteomics; Tandem Mass Spectrometry | 2016 |
Antibody-Free Approach for the Global Analysis of Protein Methylation.
Topics: Arginine; Hep G2 Cells; Humans; Hydrogen-Ion Concentration; Lysine; Methylation; Peptides; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization | 2016 |
Regulation of Vegetative Phase Change by SWI2/SNF2 Chromatin Remodeling ATPase BRAHMA.
Topics: Adenosine Triphosphatases; Arabidopsis; Arabidopsis Proteins; Chromatin Assembly and Disassembly; Gene Expression Regulation, Plant; Genes, Plant; Genetic Loci; Histones; Homeodomain Proteins; Lysine; Methylation; MicroRNAs; Models, Biological; Mutation; Nucleosomes; Phenotype; Promoter Regions, Genetic; Protein Binding | 2016 |
α-Synuclein enhances histone H3 lysine-9 dimethylation and H3K9me2-dependent transcriptional responses.
Topics: alpha-Synuclein; Animals; Animals, Genetically Modified; Cell Line, Tumor; Drosophila melanogaster; Histocompatibility Antigens; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Male; Methylation; Mice; Neuroblastoma; Repressor Proteins; Transcription, Genetic | 2016 |
Histone H3 Lysine 4 Trimethylation, Lysine 27 Trimethylation, and Lysine 27 Acetylation Contribute to the Transcriptional Repression of Solute Carrier Family 47 Member 2 in Renal Cell Carcinoma.
Topics: Acetylation; Carcinoma, Renal Cell; Cell Line, Tumor; Chromatin Immunoprecipitation; Epigenesis, Genetic; HEK293 Cells; Histones; Humans; Kidney Neoplasms; Lysine; Methylation; Organic Cation Transport Proteins; Transcription, Genetic | 2017 |
Reader domain specificity and lysine demethylase-4 family function.
Topics: Animals; Binding Sites; Crystallography, X-Ray; Histones; Humans; Isoenzymes; Jumonji Domain-Containing Histone Demethylases; Lysine; Male; Methylation; Mice, Inbred C57BL; Models, Molecular; Protein Domains; Protein Processing, Post-Translational; Rats, Sprague-Dawley | 2016 |
G9a participates in nerve injury-induced Kcna2 downregulation in primary sensory neurons.
Topics: Action Potentials; Animals; Axotomy; Cells, Cultured; Down-Regulation; Ganglia, Spinal; Histone-Lysine N-Methyltransferase; Histones; Hypersensitivity; Ion Channel Gating; Kv1.2 Potassium Channel; Ligation; Lysine; Male; Methylation; Mice, Inbred C57BL; Neuralgia; RNA, Messenger; Sensory Receptor Cells; Spinal Nerves | 2016 |
Histone chaperone APLF regulates induction of pluripotency in murine fibroblasts.
Topics: Animals; Cadherins; Carrier Proteins; Cell Cycle Checkpoints; Cell Differentiation; Cellular Reprogramming; Colony-Forming Units Assay; DNA Repair; DNA-(Apurinic or Apyrimidinic Site) Lyase; Down-Regulation; Embryo, Mammalian; Epithelial Cells; Female; Fibroblasts; Gene Knockdown Techniques; HEK293 Cells; Histone Chaperones; Histones; Humans; Induced Pluripotent Stem Cells; Kruppel-Like Factor 4; Lysine; Male; Mesoderm; Methylation; Mice; Mice, Inbred C57BL; Poly-ADP-Ribose Binding Proteins; Promoter Regions, Genetic; Up-Regulation | 2016 |
Alteration of histone H3 lysine 9 dimethylation in peripheral white blood cells of septic patients with trauma and cancer.
Topics: Adult; Aged; Aged, 80 and over; C-Reactive Protein; Female; Fluorescent Antibody Technique; Histones; Humans; Leukocytes; Lysine; Male; Methylation; Middle Aged; Neoplasms; ROC Curve; Sepsis; Wounds and Injuries | 2016 |
Selective suppression of antisense transcription by Set2-mediated H3K36 methylation.
Topics: Gene Deletion; Gene Expression Regulation, Fungal; Genome, Fungal; Histones; Lysine; Methylation; Methyltransferases; Open Reading Frames; Reproducibility of Results; RNA Stability; RNA, Antisense; RNA, Messenger; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Transcription, Genetic | 2016 |
Modulation of mRNA and lncRNA expression dynamics by the Set2-Rpd3S pathway.
Topics: Gene Expression Regulation, Fungal; Histones; Kinetics; Lysine; Methylation; Methyltransferases; Models, Biological; Promoter Regions, Genetic; RNA, Long Noncoding; RNA, Messenger; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Transcription, Genetic | 2016 |
Jarid2 binds mono-ubiquitylated H2A lysine 119 to mediate crosstalk between Polycomb complexes PRC1 and PRC2.
Topics: Amino Acid Motifs; Amino Acid Sequence; Animals; DNA Methylation; Histones; Lysine; Methylation; Mice; Nucleosomes; Polycomb Repressive Complex 1; Polycomb Repressive Complex 2; Protein Binding; Protein Domains; Ubiquitination; X Chromosome Inactivation | 2016 |
A Genetically Encoded Allysine for the Synthesis of Proteins with Site-Specific Lysine Dimethylation.
Topics: 2-Aminoadipic Acid; Escherichia coli; Genetic Code; Histones; Humans; Lysine; Methylation; Models, Molecular; Mutagenesis, Site-Directed; Protein Processing, Post-Translational; Tumor Suppressor Protein p53 | 2017 |
A Transcription Factor Pulse Can Prime Chromatin for Heritable Transcriptional Memory.
Topics: CCAAT-Enhancer-Binding Protein-alpha; Chromatin; Enhancer Elements, Genetic; Gene Expression Regulation; Histones; Lipopolysaccharides; Lysine; Methylation; Protein Binding; RNA Polymerase II; Transcription Factors; Transcription, Genetic | 2017 |
Perturbation of H3K27me3-Associated Epigenetic Processes Increases Agrobacterium-Mediated Transformation.
Topics: Agrobacterium; Amino Acid Sequence; Arabidopsis; Arabidopsis Proteins; Chromatin; Epigenesis, Genetic; Evolution, Molecular; Gene Expression Regulation, Plant; Genes, Plant; Histones; Lysine; Methylation; Plant Roots; Plants, Genetically Modified; Transformation, Genetic | 2017 |
Kinetic isotope effects reveal early transition state of protein lysine methyltransferase SET8.
Topics: Binding, Competitive; Catalysis; Cell Cycle; Computer Simulation; Histone-Lysine N-Methyltransferase; Histones; Humans; Isotopes; Kinetics; Lysine; Methylation; Models, Molecular; Models, Theoretical; Neoplasm Metastasis; Peptides; Protein Structure, Secondary; S-Adenosylmethionine; Software; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; Substrate Specificity | 2016 |
Histone H3 Lysine 9 Acetylation Obstructs ATM Activation and Promotes Ionizing Radiation Sensitivity in Normal Stem Cells.
Topics: Acetylation; Animals; Ataxia Telangiectasia Mutated Proteins; DNA Breaks; DNA Repair; Down-Regulation; Embryonic Stem Cells; Histone Acetyltransferases; Histones; Lysine; Methylation; Mice, Inbred C57BL; Neural Stem Cells; Radiation Tolerance; Radiation, Ionizing; Up-Regulation | 2016 |
LSD1 Substrate Binding and Gene Expression Are Affected by HDAC1-Mediated Deacetylation.
Topics: Acetylation; Gene Expression; HEK293 Cells; HeLa Cells; Histone Deacetylase 1; Histone Deacetylase Inhibitors; Histone Demethylases; Histones; Humans; Hydroxamic Acids; Indoles; Lysine; MCF-7 Cells; Methylation; Models, Chemical; Vorinostat | 2017 |
World Trade Center (WTC) dust exposure in mice is associated with inflammation, oxidative stress and epigenetic changes in the lung.
Topics: Air Pollutants; Animals; Blotting, Western; Cyclooxygenase 2; Cytokines; DNA Methylation; Dust; Epigenesis, Genetic; Female; Gene Expression; Heme Oxygenase-1; Histones; Humans; Immunohistochemistry; Inflammation; Inhalation Exposure; Lung; Lysine; Matrix Metalloproteinases; Methylation; Mice, Inbred C57BL; Oxidative Stress; Reverse Transcriptase Polymerase Chain Reaction; September 11 Terrorist Attacks; Up-Regulation | 2017 |
Adaptive Chromatin Remodeling Drives Glioblastoma Stem Cell Plasticity and Drug Tolerance.
Topics: Acetylation; Base Sequence; Biomarkers, Tumor; Brain; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Chromatin Assembly and Disassembly; Drug Resistance, Neoplasm; Enhancer Elements, Genetic; Glioblastoma; Histone Demethylases; Histones; Humans; Jumonji Domain-Containing Histone Demethylases; Lysine; Methylation; Neoplastic Stem Cells; Nuclear Proteins; Protein Binding; Protein Kinase Inhibitors; Protein Kinases; Receptors, Notch; Signal Transduction; Transcription, Genetic | 2017 |
Human Naive Pluripotent Stem Cells Model X Chromosome Dampening and X Inactivation.
Topics: Base Sequence; Blastocyst; Cell Differentiation; Cells, Cultured; Chromosomes, Human, X; DNA Methylation; Female; Histones; Human Embryonic Stem Cells; Humans; Lysine; Methylation; Pluripotent Stem Cells; RNA, Long Noncoding; X Chromosome Inactivation | 2017 |
Mutations in the histone methyltransferase gene KMT2B cause complex early-onset dystonia.
Topics: Adolescent; DNA-Binding Proteins; Dystonia; Female; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Male; Methylation; Mutation; Nuclear Proteins | 2017 |
Soft matrices downregulate FAK activity to promote growth of tumor-repopulating cells.
Topics: Animals; cdc42 GTP-Binding Protein; Cell Culture Techniques; Cell Line, Tumor; Cell Proliferation; Down-Regulation; Focal Adhesion Kinase 1; Histones; Humans; Lysine; Melanoma; Methylation; Mice; rhoA GTP-Binding Protein; SOXB1 Transcription Factors; Tumor Stem Cell Assay | 2017 |
Editor's Highlight: Organ-Specific Epigenetic Changes Induced by the Nongenotoxic Liver Carcinogen Methapyrilene in Fischer 344 Rats.
Topics: Acetylation; Administration, Oral; Animals; Benzofurans; Carcinogens; Chromatin Assembly and Disassembly; Dose-Response Relationship, Drug; Epigenesis, Genetic; Hepatocyte Nuclear Factor 1-alpha; Histones; Homeodomain Proteins; Kidney; Liver; Lysine; Male; Methapyrilene; Methylation; Organ Specificity; PPAR alpha; Protein Processing, Post-Translational; Random Allocation; Rats, Inbred F344; Tumor Suppressor Proteins | 2017 |
SETD4 Regulates Cell Quiescence and Catalyzes the Trimethylation of H4K20 during Diapause Formation in Artemia.
Topics: Amino Acid Sequence; Animals; Artemia; Base Sequence; Biocatalysis; Cell Cycle; Cell Division; Cell Line, Tumor; Diapause, Insect; Embryo, Nonmammalian; Gene Knockdown Techniques; Histones; Lysine; Methylation; Transcription Factors | 2017 |
Coordination of Cell Cycle Progression and Mitotic Spindle Assembly Involves Histone H3 Lysine 4 Methylation by Set1/COMPASS.
Topics: Chromatin; DNA-Binding Proteins; Histone-Lysine N-Methyltransferase; Histones; Lysine; M Phase Cell Cycle Checkpoints; Methylation; Mitosis; Protein Processing, Post-Translational; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Spindle Apparatus; Transcription Factors; Ubiquitination | 2017 |
Chaetocin reactivates the lytic replication of Epstein-Barr virus from latency via reactive oxygen species.
Topics: Acetylcysteine; Animals; Antigens, Viral; B-Lymphocytes; Blotting, Western; Callithrix; Cell Line, Transformed; Dose-Response Relationship, Drug; Free Radical Scavengers; Gene Expression Regulation; Glutathione Peroxidase; Herpesvirus 4, Human; Histones; Host-Pathogen Interactions; Humans; Lysine; Methylation; NADH Dehydrogenase; Phospholipid Hydroperoxide Glutathione Peroxidase; Piperazines; Reactive Oxygen Species; Reverse Transcriptase Polymerase Chain Reaction; Trans-Activators; Virus Activation; Virus Latency; Virus Replication | 2017 |
Discovery of First-in-Class, Potent, and Orally Bioavailable Embryonic Ectoderm Development (EED) Inhibitor with Robust Anticancer Efficacy.
Topics: Animals; Antineoplastic Agents; Cell Proliferation; Crystallography, X-Ray; Dogs; Female; Haplorhini; Histones; Humans; Lymphoma, Large B-Cell, Diffuse; Lysine; Male; Methylation; Mice; Mice, Inbred BALB C; Mice, Nude; Molecular Docking Simulation; Polycomb Repressive Complex 2; Rats; Sulfones; Triazoles | 2017 |
WHSC1L1-mediated EGFR mono-methylation enhances the cytoplasmic and nuclear oncogenic activity of EGFR in head and neck cancer.
Topics: Antineoplastic Agents; Biomarkers; Cell Nucleus; Cytoplasm; DNA Replication; Drug Resistance, Neoplasm; ErbB Receptors; Erlotinib Hydrochloride; Gene Knockdown Techniques; Head and Neck Neoplasms; Histone-Lysine N-Methyltransferase; Humans; Immunohistochemistry; Lysine; Methylation; Models, Biological; Nuclear Proteins; Proliferating Cell Nuclear Antigen; Protein Binding; Protein Interaction Domains and Motifs; Protein Kinase Inhibitors; Protein Transport | 2017 |
Probe the function of histone lysine 36 methylation using histone H3 lysine 36 to methionine mutant transgene in mammalian cells.
Topics: Amino Acid Substitution; Cell Line, Transformed; Cell Transformation, Neoplastic; Chondrocytes; Chromatin; Epigenesis, Genetic; HEK293 Cells; Histones; Humans; Lysine; Methionine; Methylation; Mutation; Protein Processing, Post-Translational; Signal Transduction | 2017 |
The cysteine-rich domain of TET2 binds preferentially to mono- and dimethylated histone H3K36.
Topics: Binding Sites; Chromatin; Cysteine; Dioxygenases; DNA-Binding Proteins; HEK293 Cells; Histones; Humans; Immunoblotting; Lysine; Methylation; Microscopy, Confocal; Models, Molecular; Mutation, Missense; Protein Binding; Protein Domains; Proto-Oncogene Proteins | 2017 |
Vernalization-Triggered Intragenic Chromatin Loop Formation by Long Noncoding RNAs.
Topics: Arabidopsis; Arabidopsis Proteins; Chromatin; Cold Temperature; Flowers; Gene Expression Regulation, Plant; Gene Silencing; Genetic Loci; Histones; Lysine; MADS Domain Proteins; Methylation; Mutation; Nucleic Acid Conformation; Plants, Genetically Modified; Polycomb Repressive Complex 2; Promoter Regions, Genetic; Repressor Proteins; RNA, Long Noncoding | 2017 |
Topics: Alcohol Oxidoreductases; Animals; Atrophy; Body Weight; Demyelinating Diseases; Gene Deletion; Gliosis; Glutarates; Hippocampus; Histones; Inflammation; Leukoencephalopathies; Lysine; Male; Methylation; Mice, Knockout; Nerve Degeneration; Neurogenesis; Neuroglia; Organ Size; Testis; White Matter | 2017 |
Clr4 specificity and catalytic activity beyond H3K9 methylation.
Topics: Cell Cycle Proteins; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Methyltransferases; Protein Processing, Post-Translational; Schizosaccharomyces; Schizosaccharomyces pombe Proteins; Substrate Specificity | 2017 |
Synthetic essentiality of chromatin remodelling factor CHD1 in PTEN-deficient cancer.
Topics: beta-Transducin Repeat-Containing Proteins; Breast Neoplasms; Cell Line, Tumor; Chromatin Assembly and Disassembly; DNA Helicases; DNA-Binding Proteins; Female; Gene Expression Regulation, Neoplastic; Genes, Essential; Glycogen Synthase Kinase 3 beta; Histones; Humans; Lysine; Male; Methylation; Molecular Targeted Therapy; Neoplasms; NF-kappa B; Phosphorylation; Prostatic Neoplasms; Proteasome Endopeptidase Complex; Protein Stability; Proteolysis; PTEN Phosphohydrolase; Tumor Necrosis Factor-alpha; Ubiquitination | 2017 |
Pathogenesis of Osteosclerotic Change Following Treatment with an Antibody Against RANKL for Giant Cell Tumour of the Bone.
Topics: Adult; Alkaline Phosphatase; Bone and Bones; Bone Density Conservation Agents; Bone Neoplasms; Denosumab; Female; Giant Cell Tumor of Bone; Histones; Humans; Immunohistochemistry; Lysine; Male; Methylation; Microscopy, Fluorescence; Middle Aged; Osteocalcin; Osteogenesis; RANK Ligand | 2017 |
G1 cyclins link proliferation, pluripotency and differentiation of embryonic stem cells.
Topics: Animals; Biomarkers; Cell Cycle; Cell Differentiation; Cell Proliferation; Cell Separation; Cyclin G1; DNA; Embryo, Mammalian; Epigenesis, Genetic; Female; Flow Cytometry; Gene Expression Profiling; Histones; Hormones; Imaging, Three-Dimensional; Lysine; Mammary Glands, Animal; Methylation; Mice; Mice, Inbred C57BL; Mouse Embryonic Stem Cells; Receptors, G-Protein-Coupled; RNA; Steroids; Tetraspanins | 2017 |
Acidic domains differentially read histone H3 lysine 4 methylation status and are widely present in chromatin-associated proteins.
Topics: Amino Acid Sequence; Binding Sites; Chromatin; DNA-Binding Proteins; HEK293 Cells; HeLa Cells; Histone Chaperones; Histones; Humans; Intracellular Signaling Peptides and Proteins; Lysine; Methylation; Nuclear Proteins; Nucleolin; Nucleophosmin; Phosphoproteins; Pol1 Transcription Initiation Complex Proteins; Protein Binding; Protein Domains; RNA-Binding Proteins; Transcription Factors | 2017 |
Histone Lysine-to-Methionine Mutations Reduce Histone Methylation and Cause Developmental Pleiotropy.
Topics: Amino Acid Substitution; Arabidopsis; Arabidopsis Proteins; Epigenesis, Genetic; Flowers; Gene Expression Profiling; Gene Expression Regulation, Developmental; Gene Expression Regulation, Plant; Gene Ontology; Genetic Pleiotropy; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Immunoblotting; Lysine; Methionine; Methylation; Mutation; Plants, Genetically Modified; Reverse Transcriptase Polymerase Chain Reaction; Time Factors | 2017 |
Menin regulates Inhbb expression through an Akt/Ezh2-mediated H3K27 histone modification.
Topics: Animals; Cell Line, Tumor; Embryo, Mammalian; Enhancer of Zeste Homolog 2 Protein; Fibroblasts; Gene Expression Regulation; Genetic Loci; Histones; Inhibin-beta Subunits; Lysine; Methylation; Mice, Inbred C57BL; Mice, Knockout; Phosphorylation; Polycomb Repressive Complex 1; Polycomb Repressive Complex 2; Promoter Regions, Genetic; Protein Binding; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Signal Transduction | 2017 |
MKL1 is an epigenetic mediator of TNF-α-induced proinflammatory transcription in macrophages by interacting with ASH2.
Topics: Adult; Amino Acid Sequence; Animals; Cell Line; Cell Line, Tumor; Cells, Cultured; Cytokines; DNA-Binding Proteins; Electrophoresis, Polyacrylamide Gel; Epigenesis, Genetic; Gene Expression Regulation; HEK293 Cells; Histones; Humans; Inflammation Mediators; Lysine; Macrophages; Male; Methylation; Mice, Knockout; NF-kappa B; Nuclear Proteins; Protein Binding; Reverse Transcriptase Polymerase Chain Reaction; Trans-Activators; Transcription Factors; Tumor Necrosis Factor-alpha | 2017 |
Chromatin reader ZMYND8 is a key target of all trans retinoic acid-mediated inhibition of cancer cell proliferation.
Topics: Animals; Cell Line, Tumor; Cell Proliferation; Chromatin; Chromatin Immunoprecipitation; Fluorescent Antibody Technique; Histone Deacetylases; Histones; Humans; Lysine; Methylation; Mice; Neoplasms; Polymerase Chain Reaction; Promoter Regions, Genetic; Receptors for Activated C Kinase; Receptors, Cell Surface; Response Elements; RNA Polymerase II; Time Factors; Tretinoin; Tumor Suppressor Proteins; YY1 Transcription Factor | 2017 |
TIRR regulates 53BP1 by masking its histone methyl-lysine binding function.
Topics: Animals; Ataxia Telangiectasia Mutated Proteins; Binding Sites; Carrier Proteins; DNA Breaks, Double-Stranded; DNA Repair; Female; Histones; Humans; Lysine; Methylation; Mice; Mice, Inbred C57BL; Phosphorylation; Protein Binding; Protein Domains; RNA-Binding Proteins; Telomere-Binding Proteins; Tumor Suppressor p53-Binding Protein 1 | 2017 |
Hsp90 inhibition destabilizes Ezh2 protein in alloreactive T cells and reduces graft-versus-host disease in mice.
Topics: Animals; Enhancer of Zeste Homolog 2 Protein; Graft vs Host Disease; Hematopoiesis; Hematopoietic Stem Cell Transplantation; Histones; HSP90 Heat-Shock Proteins; Indoles; Isoxazoles; Lysine; Methylation; Mice, Inbred BALB C; Mice, Inbred C57BL; Minor Histocompatibility Antigens; Protein Domains; Protein Stability; Pyridones; Resorcinols; T-Lymphocytes; Transplantation, Homologous | 2017 |
The SETD8/PR-Set7 Methyltransferase Functions as a Barrier to Prevent Senescence-Associated Metabolic Remodeling.
Topics: Cell Line; Cell Nucleolus; Cellular Senescence; Chromatin; Cyclin-Dependent Kinase Inhibitor p16; DNA Replication; Down-Regulation; Gene Expression Regulation; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Methyltransferases; Mitochondria; Ribosomal Proteins; RNA, Ribosomal | 2017 |
EZH1 in germ cells safeguards the function of PRC2 during spermatogenesis.
Topics: Animals; Base Sequence; Enhancer of Zeste Homolog 2 Protein; Fertility; Gene Deletion; Genome; Histones; Lysine; Male; Methylation; Mice, Knockout; Mitosis; Models, Biological; Polycomb Repressive Complex 2; Spermatogenesis; Spermatozoa; Testis | 2017 |
Enhancer-Mediated Oncogenic Function of the Menin Tumor Suppressor in Breast Cancer.
Topics: Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Enhancer Elements, Genetic; Estradiol; Estrogen Receptor alpha; Female; GATA3 Transcription Factor; Gene Expression Regulation, Neoplastic; Genomics; Hepatocyte Nuclear Factor 3-alpha; Histones; Humans; Lysine; Methylation; Oncogenes; Promoter Regions, Genetic; Protein Binding; Proto-Oncogene Proteins; Transcription, Genetic | 2017 |
Comparative analyses identify molecular signature of MRI-classified SVZ-associated glioblastoma.
Topics: Brain Neoplasms; Cell Line, Tumor; Epigenesis, Genetic; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Glioblastoma; Histones; Humans; Isocitrate Dehydrogenase; Lateral Ventricles; Lysine; Magnetic Resonance Imaging; Methylation; Mutation; Neoplastic Stem Cells; Neural Stem Cells; Sequence Analysis, RNA | 2017 |
MacroH2A histone variants maintain nuclear organization and heterochromatin architecture.
Topics: Cell Nucleolus; HEK293 Cells; Hep G2 Cells; Heterochromatin; Histones; Humans; Lamin Type B; Lysine; Male; Methylation; Protein Binding | 2017 |
Histone peptide microarray screen of chromo and Tudor domains defines new histone lysine methylation interactions.
Topics: Cell Cycle Proteins; Chromobox Protein Homolog 5; Chromosomal Proteins, Non-Histone; HEK293 Cells; Histones; Humans; Lysine; Methylation; Microtubule-Associated Proteins; Phosphoproteins; Protein Array Analysis; Protein Interaction Domains and Motifs; Tudor Domain | 2017 |
Chromatin modification contributes to the expression divergence of three TaGS2 homoeologs in hexaploid wheat.
Topics: Chromatin; Chromatin Immunoprecipitation; DNA Methylation; Exons; Gene Expression Regulation, Plant; Genes, Plant; Histones; Lysine; Methylation; Plant Leaves; Plant Proteins; Plant Roots; Polyploidy; RNA, Messenger; Sequence Homology, Amino Acid; Time Factors; Triticum | 2017 |
Regulatory signatures of liver regeneration distilled by integrative analysis of mRNA, histone methylation, and proteomics.
Topics: Amino Acid Motifs; Animals; Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; Epigenesis, Genetic; Forkhead Box Protein M1; Gene Expression Regulation; Histones; Liver; Liver Neoplasms; Liver Regeneration; Lysine; Male; Methylation; Mice; Mice, Inbred C57BL; Promoter Regions, Genetic; Proteome; RNA, Messenger; Transcriptome | 2017 |
Propagation of Polycomb-repressed chromatin requires sequence-specific recruitment to DNA.
Topics: Animals; Chromatin; DNA; DNA Replication; Drosophila melanogaster; Drosophila Proteins; Gene Expression Regulation; Genes, Homeobox; Genes, Reporter; Histones; Lysine; Methylation; Nucleosomes; Polycomb Repressive Complex 2; Response Elements | 2017 |
Causal role for inheritance of H3K27me3 in maintaining the OFF state of a
Topics: Animals; Cell Division; Chromatin; Drosophila melanogaster; Drosophila Proteins; Gene Expression Regulation, Developmental; Gene Silencing; Genes, Homeobox; Histone-Lysine N-Methyltransferase; Histones; Homeodomain Proteins; Lysine; Methylation; Nucleosomes; Promoter Regions, Genetic; Transcription Factors | 2017 |
Reprogramming of histone methylation controls the differentiation of monocytes into macrophages.
Topics: Animals; Bone Marrow Cells; Cell Differentiation; Cell Line, Tumor; Cells, Cultured; Chromatin Immunoprecipitation; Epigenesis, Genetic; Forkhead Transcription Factors; Gene Expression Regulation, Developmental; Histones; Homeodomain Proteins; Humans; Kruppel-Like Factor 4; Lysine; Macrophages; Methylation; Mice, Inbred C57BL; Monocytes; Promoter Regions, Genetic; Protein Processing, Post-Translational; RNA Interference; Specific Pathogen-Free Organisms; Transcription Factors | 2017 |
Foxh1 Occupies cis-Regulatory Modules Prior to Dynamic Transcription Factor Interactions Controlling the Mesendoderm Gene Program.
Topics: Animals; Blastula; Cleavage Stage, Ovum; Co-Repressor Proteins; Embryo, Nonmammalian; Endoderm; Enhancer Elements, Genetic; Forkhead Transcription Factors; Gene Expression Regulation, Developmental; Genome; Histones; Lysine; Mesoderm; Methylation; Nodal Protein; Protein Binding; Regulatory Sequences, Nucleic Acid; RNA Polymerase II; RNA, Messenger; Sequence Analysis, RNA; Signal Transduction; Transcription Factors; Transcription, Genetic; Xenopus; Xenopus Proteins | 2017 |
Trimethylation and Acetylation of β-Catenin at Lysine 49 Represent Key Elements in ESC Pluripotency.
Topics: Acetylation; Animals; Antibodies, Monoclonal; beta Catenin; Cell Differentiation; Embryonic Stem Cells; Enhancer of Zeste Homolog 2 Protein; Gene Expression Regulation; Lysine; Methylation; Mutation; Pluripotent Stem Cells; Polycomb Repressive Complex 2; Promoter Regions, Genetic; Rats, Inbred Lew | 2017 |
ERRα induces H3K9 demethylation by LSD1 to promote cell invasion.
Topics: Cell Movement; ERRalpha Estrogen-Related Receptor; Gene Expression Regulation; HEK293 Cells; Histone Demethylases; Histones; Humans; Lysine; Matrix Metalloproteinase 1; Methylation; Promoter Regions, Genetic; Receptors, Estrogen; Transcription Initiation Site | 2017 |
SMARCAD1 Contributes to the Regulation of Naive Pluripotency by Interacting with Histone Citrullination.
Topics: Animals; Base Sequence; Binding Sites; Cells, Cultured; Chromatin; Citrullination; DNA Helicases; Embryo, Mammalian; Embryonic Development; Embryonic Stem Cells; Epigenesis, Genetic; Female; Gene Knockdown Techniques; Genome; Histones; Lysine; Male; Methylation; Mice; Nuclear Proteins; Phenotype; Pluripotent Stem Cells; Protein Binding; Protein Processing, Post-Translational; Transcriptome | 2017 |
A Metabolic Function for Phospholipid and Histone Methylation.
Topics: Cysteine; Energy Metabolism; Gene Expression Profiling; Gene Expression Regulation, Enzymologic; Gene Expression Regulation, Fungal; Histones; Lysine; Methylation; Mutation; Oxidative Stress; Phosphatidylcholines; Phosphatidylethanolamine N-Methyltransferase; Phosphatidylethanolamines; Protein Phosphatase 2; Protein Processing, Post-Translational; S-Adenosylhomocysteine; S-Adenosylmethionine; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Time Factors; Transcription, Genetic | 2017 |
Mono-unsaturated fatty acids link H3K4me3 modifiers to C. elegans lifespan.
Topics: Aging; Animals; Caenorhabditis elegans; Dietary Fats; Down-Regulation; Fatty Acid Desaturases; Fatty Acids, Unsaturated; Gene Expression Regulation, Enzymologic; Germ Cells; Histone-Lysine N-Methyltransferase; Histones; Intestinal Mucosa; Intestines; Lipid Metabolism; Longevity; Lysine; Methylation; Ribosomal Protein S6 Kinases, 70-kDa; Stearoyl-CoA Desaturase; Up-Regulation | 2017 |
Human METTL12 is a mitochondrial methyltransferase that modifies citrate synthase.
Topics: Amino Acid Sequence; Catalytic Domain; Citrate (si)-Synthase; Computational Biology; Conserved Sequence; CRISPR-Cas Systems; Frameshift Mutation; HEK293 Cells; Humans; Lysine; Methylation; Methyltransferases; Mitochondria; Protein Interaction Domains and Motifs; Protein Processing, Post-Translational; Protein Structure, Secondary; Protein Transport; Recombinant Fusion Proteins; Substrate Specificity; Surface Properties | 2017 |
Reduced Histone H3 Lysine 9 Methylation Contributes to the Pathogenesis of Latent Autoimmune Diabetes in Adults via Regulation of SUV39H2 and KDM4C.
Topics: Adult; Case-Control Studies; CD4-Positive T-Lymphocytes; Diabetes Mellitus, Type 1; Down-Regulation; Female; Gene Expression Profiling; Gene Expression Regulation, Enzymologic; Glycated Hemoglobin; Glycosylation; Histone-Lysine N-Methyltransferase; Histones; Humans; Jumonji Domain-Containing Histone Demethylases; Lysine; Male; Methylation; Middle Aged | 2017 |
Polycomb Repressive Complex 2-Mediated Chromatin Repression Guides Effector CD8
Topics: Animals; CD8-Positive T-Lymphocytes; Cell Differentiation; Chromatin; Enhancer of Zeste Homolog 2 Protein; Flow Cytometry; Forkhead Box Protein O1; Gene Expression; Histones; Immunoblotting; Immunologic Memory; Lysine; Methylation; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Models, Immunological; Multipotent Stem Cells; Polycomb Repressive Complex 2; Reverse Transcriptase Polymerase Chain Reaction | 2017 |
Lysine-specific demethylase-1 (LSD1) depletion disrupts monogenic and monoallelic odorant receptor (OR) expression in an olfactory neuronal cell line.
Topics: Animals; Cell Line; Gene Expression; Histone Demethylases; Histones; Lysine; Methylation; Mice; Olfactory Receptor Neurons; Receptors, Odorant; Smell | 2017 |
Transgenerational transmission of environmental information in
Topics: Animals; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Environment; Environmental Biomarkers; Epigenesis, Genetic; Female; Heterochromatin; Histone-Lysine N-Methyltransferase; Histones; Hot Temperature; Lysine; Male; Methylation; Oligonucleotide Array Sequence Analysis; Oocytes; Spermatozoa; Transcription, Genetic; Zygote | 2017 |
Total chemical synthesis of methylated analogues of histone 3 revealed KDM4D as a potential regulator of H3K79me3.
Topics: Amino Acid Sequence; Catalysis; Chromatography, High Pressure Liquid; Coordination Complexes; Histones; Jumonji Domain-Containing Histone Demethylases; Lysine; Methylation | 2017 |
SDG2-Mediated H3K4me3 Is Crucial for Chromatin Condensation and Mitotic Division during Male Gametogenesis in Arabidopsis.
Topics: Arabidopsis; Arabidopsis Proteins; Cell Nucleus; Chromatin; Gametogenesis, Plant; Gene Expression Regulation, Plant; Germination; Heterochromatin; Histones; Lysine; Meiosis; Methylation; Mitosis; Mutation; Pollen; Pollen Tube; Retroelements | 2017 |
Use of Histone K-M Mutants for the Analysis of Transcriptional Regulation in Mouse Zygotes.
Topics: Amino Acid Substitution; Animals; Epigenesis, Genetic; Gene Expression Regulation, Developmental; Histone Code; Histones; Lysine; Methionine; Methylation; Mice; Mutation; Transcriptional Activation; Zygote | 2017 |
SMYD2-Mediated Histone Methylation Contributes to HIV-1 Latency.
Topics: CD4-Positive T-Lymphocytes; Cell Line; Chromatin; Chromosomal Proteins, Non-Histone; DNA, Recombinant; Female; HEK293 Cells; Histone-Lysine N-Methyltransferase; Histones; HIV-1; Humans; Lysine; Methylation; Promoter Regions, Genetic; Repressor Proteins; RNA, Small Interfering; T-Lymphocytes; Tumor Suppressor Proteins; Virus Latency | 2017 |
Proteins with Site-Specific Lysine Methylation.
Topics: Chromatin; Histones; Humans; Lysine; Methylation; Proteins | 2017 |
Temporal dynamics of gene expression and histone marks at the Arabidopsis shoot meristem during flowering.
Topics: Arabidopsis; Chromatin; Flowers; Gene Expression Profiling; Gene Expression Regulation, Plant; Genes, Plant; Histone Code; Histones; Lysine; Meristem; Methylation; Time Factors | 2017 |
Methylation of human eukaryotic elongation factor alpha (eEF1A) by a member of a novel protein lysine methyltransferase family modulates mRNA translation.
Topics: Amino Acid Sequence; Base Sequence; Cell Line; Electrophoresis, Polyacrylamide Gel; Eukaryotic Initiation Factor-1; Gene Knockout Techniques; Histone-Lysine N-Methyltransferase; Humans; Lysine; Methylation; Methyltransferases; Phylogeny; Protein Biosynthesis; RNA, Messenger; Sequence Homology, Amino Acid | 2017 |
MORC-1 Integrates Nuclear RNAi and Transgenerational Chromatin Architecture to Promote Germline Immortality.
Topics: Animals; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Cell Nucleus; Chromatin; Genome; Germ Cells; Heterochromatin; Histones; Inheritance Patterns; Lysine; Methylation; Models, Biological; Mutation; Nuclear Proteins; RNA Interference; RNA, Small Interfering | 2017 |
DNA damage and S phase-dependent E2F1 stabilization requires the cIAP1 E3-ubiquitin ligase and is associated with K63-poly-ubiquitination on lysine 161/164 residues.
Topics: Animals; Arginine; DNA Damage; E2F1 Transcription Factor; Humans; Inhibitor of Apoptosis Proteins; Lysine; Methylation; Mice; Polyubiquitin; Protein Stability; S Phase; Structure-Activity Relationship; Transcription, Genetic; Ubiquitin-Protein Ligases; Ubiquitination | 2017 |
Cross-talk between the H3K36me3 and H4K16ac histone epigenetic marks in DNA double-strand break repair.
Topics: Acetylation; Adaptor Proteins, Signal Transducing; Biomarkers; Cell Line, Tumor; Chromatin; CRISPR-Cas Systems; DNA; DNA Breaks, Double-Stranded; DNA Repair; Epigenesis, Genetic; Gene Knockout Techniques; HEK293 Cells; Histone Acetyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Lysine Acetyltransferase 5; Methylation; Protein Processing, Post-Translational; Protein Transport; Recombinant Proteins; RNA Interference; Transcription Factors | 2017 |
Hyperactivation of HUSH complex function by Charcot-Marie-Tooth disease mutation in MORC2.
Topics: Adenosine Triphosphatases; Charcot-Marie-Tooth Disease; Chromatin Assembly and Disassembly; CRISPR-Cas Systems; Epigenetic Repression; Gene Silencing; HeLa Cells; Heterochromatin; Histone Code; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Multiprotein Complexes; Mutation, Missense; Neurons; Protein Domains; Protein Interaction Mapping; Protein Methyltransferases; Protein Processing, Post-Translational; Transcription Factors; Transgenes | 2017 |
Arabidopsis FRIGIDA stimulates EFS histone H3 Lys36 methyltransferase activity.
Topics: Amino Acid Sequence; Arabidopsis; Arabidopsis Proteins; Blotting, Western; Histone-Lysine N-Methyltransferase; Histones; Kinetics; Lysine; Methylation; Mutation; Sequence Homology, Amino Acid; Substrate Specificity | 2017 |
LSD1 knockdown reveals novel histone lysine methylation in human breast cancer MCF-7 cells.
Topics: Amino Acid Sequence; Female; Gene Knockdown Techniques; Histone Code; Histone Demethylases; Histones; Humans; Lysine; MCF-7 Cells; Methylation; Promoter Regions, Genetic; Protein Processing, Post-Translational; Tandem Mass Spectrometry; Transcription, Genetic | 2017 |
Retrotransposons are specified as DNA replication origins in the gene-poor regions of Arabidopsis heterochromatin.
Topics: Arabidopsis; Cell Line; Chromatin; Chromosome Mapping; DNA Replication; DNA, Plant; GC Rich Sequence; Genome, Plant; Heterochromatin; Histones; Lysine; Methylation; Microscopy, Confocal; Replication Origin; Retroelements; Reverse Transcriptase Polymerase Chain Reaction; Transcription, Genetic | 2017 |
Polycomb repressive complex 2 in an autoinhibited state.
Topics: Amino Acid Sequence; Amino Acid Substitution; Animals; Apoenzymes; Chaetomium; Coenzymes; Conserved Sequence; Enhancer of Zeste Homolog 2 Protein; Fungal Proteins; Histones; Lysine; Methylation; Models, Molecular; Mutation; Peptide Fragments; Polycomb Repressive Complex 2; Protein Interaction Domains and Motifs; Protein Processing, Post-Translational; Recombinant Fusion Proteins; S-Adenosylmethionine; Xenopus laevis; Xenopus Proteins | 2017 |
Muscle-relevant genes marked by stable H3K4me2/3 profiles and enriched MyoD binding during myogenic differentiation.
Topics: Animals; Cell Differentiation; Cell Line; Cells, Cultured; Cluster Analysis; Fibroblasts; Gene Expression Profiling; Gene Ontology; HEK293 Cells; Histones; Humans; Lysine; Methylation; Mice; Muscle Development; Myoblasts; MyoD Protein; Neoplasm Proteins; Protein Binding; Repressor Proteins; Reverse Transcriptase Polymerase Chain Reaction | 2017 |
Intricate Effects of α-Amino and Lysine Modifications on Arginine Methylation of the N-Terminal Tail of Histone H4.
Topics: Acetylation; Acylation; Amino Acid Sequence; Arginine; Histones; Humans; Lysine; Membrane Proteins; Methylation; Protein Processing, Post-Translational; Protein-Arginine N-Methyltransferases; Recombinant Proteins; Repressor Proteins | 2017 |
Environmental change drives accelerated adaptation through stimulated copy number variation.
Topics: Adaptation, Physiological; Copper; DNA Copy Number Variations; Drug Resistance; Gene Expression Profiling; Gene Expression Regulation, Developmental; Gene Expression Regulation, Fungal; Histones; Lysine; Metallothionein; Methylation; Models, Genetic; Mutation; Promoter Regions, Genetic; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Signal Transduction | 2017 |
RBM25 is a global splicing factor promoting inclusion of alternatively spliced exons and is itself regulated by lysine mono-methylation.
Topics: Alternative Splicing; Cell Line; Cell Proliferation; Cell Survival; Exons; Gene Expression Profiling; Gene Expression Regulation; High-Throughput Nucleotide Sequencing; Humans; Immobilized Proteins; Immunoprecipitation; Lysine; Methylation; Nuclear Proteins; Protein Interaction Domains and Motifs; Protein Processing, Post-Translational; Proteomics; Recombinant Fusion Proteins; RNA Precursors; RNA-Binding Proteins; RNA, Messenger; Serine-Arginine Splicing Factors; Spliceosomes | 2017 |
METTL21B Is a Novel Human Lysine Methyltransferase of Translation Elongation Factor 1A: Discovery by CRISPR/Cas9 Knockout.
Topics: Catalytic Domain; CRISPR-Cas Systems; Gene Knockout Techniques; Humans; K562 Cells; Lysine; Methylation; Methyltransferases; Models, Molecular; Peptide Elongation Factor 1; Protein Conformation; Proteomics | 2017 |
SETD2 and histone H3 lysine 36 methylation deficiency in advanced systemic mastocytosis.
Topics: Adult; Aged; Apoptosis; Cell Line, Tumor; Female; Histone-Lysine N-Methyltransferase; Histones; Humans; K562 Cells; Lysine; Male; Mast Cells; Mastocytosis; Mastocytosis, Systemic; Methylation; Middle Aged; Mutation; Prognosis; Proteasome Endopeptidase Complex; Staurosporine | 2018 |
Correlation Between Expression of Recombinant Proteins and Abundance of H3K4Me3 on the Enhancer of Human Cytomegalovirus Major Immediate-Early Promoter.
Topics: Animals; CHO Cells; Cricetinae; Cricetulus; Cytomegalovirus; DNA Methylation; Enhancer Elements, Genetic; Gene Dosage; Genes, Immediate-Early; Histones; Humans; Lysine; Methylation; Promoter Regions, Genetic; Recombinant Proteins; RNA, Messenger; Trastuzumab | 2017 |
The extraordinary thermal stability of EstA from S. islandicus is independent of post translational modifications.
Topics: Archaeal Proteins; Carboxylic Ester Hydrolases; Escherichia coli; Lysine; Methylation; Protein Processing, Post-Translational; Protein Stability; Recombinant Proteins; Sulfolobus | 2017 |
Acetylation and methylation profiles of H3K27 in porcine embryos cultured in vitro.
Topics: Acetylation; Animals; Blastocyst; Embryo Culture Techniques; Embryo, Mammalian; Female; Histones; Lysine; Methylation; Oocytes; Swine; Zygote | 2017 |
Full-length nisin immunity protein NisI from Lactococcus lactis in a lipid-free form: crystallization and X-ray analysis.
Topics: Amino Acid Sequence; Bacterial Proteins; Cloning, Molecular; Crystallization; Crystallography, X-Ray; Escherichia coli; Gene Expression; Genetic Vectors; Lactococcus lactis; Lipoproteins; Lysine; Membrane Proteins; Methylation; Nisin; Oxidation-Reduction; Protein Binding; Recombinant Fusion Proteins; X-Ray Diffraction | 2017 |
Discovery of Novel Human Gene Regulatory Modules from Gene Co-expression and Promoter Motif Analysis.
Topics: CCAAT-Binding Factor; Epigenesis, Genetic; Gene Expression Regulation; Gene Regulatory Networks; Humans; Interferon Regulatory Factor-1; Lysine; Methylation; Nucleotide Motifs; Oligonucleotide Array Sequence Analysis; Promoter Regions, Genetic; Regulatory Factor X1; Sp1 Transcription Factor; YY1 Transcription Factor | 2017 |
Tryptic Peptides Bearing C-Terminal Dimethyllysine Need to Be Considered during the Analysis of Lysine Dimethylation in Proteomic Study.
Topics: Amino Acid Sequence; Animals; Cattle; Chromatography, High Pressure Liquid; HeLa Cells; Humans; Isotope Labeling; Kinetics; Lysine; Methylation; Peptide Fragments; Protein Processing, Post-Translational; Proteolysis; Proteomics; Serine Endopeptidases; Serum Albumin, Bovine; Serum Albumin, Human; Tandem Mass Spectrometry; Trypsin | 2017 |
Drosophila Histone Demethylase KDM4A Has Enzymatic and Non-enzymatic Roles in Controlling Heterochromatin Integrity.
Topics: Animals; Biocatalysis; Cell Cycle; Cell Cycle Checkpoints; Chromosomal Position Effects; DNA Breaks, Double-Stranded; DNA Repair; Drosophila melanogaster; Drosophila Proteins; Fertility; Gene Expression Regulation; Gene Silencing; Heterochromatin; Histone Demethylases; Histones; Lysine; Methylation; Mutation; Protein Domains; Transcription, Genetic | 2017 |
Methylation, crystallization and SAD phasing of the Csu pilus CsuC-CsuE chaperone-adhesin subunit pre-assembly complex from Acinetobacter baumannii.
Topics: Acinetobacter baumannii; Adhesins, Bacterial; Amino Acid Sequence; Cloning, Molecular; Crystallization; Crystallography, X-Ray; Escherichia coli; Fimbriae, Bacterial; Gene Expression; Genetic Vectors; Lysine; Methylation; Molecular Chaperones; Polyethylene Glycols; Protein Binding; Protein Subunits; Recombinant Proteins; X-Ray Diffraction | 2017 |
MicroRNA-125b is a key epigenetic regulatory factor that promotes nuclear transfer reprogramming.
Topics: Animals; Base Sequence; Epigenesis, Genetic; Gene Expression Regulation; HEK293 Cells; Hepatocyte Nuclear Factor 1-beta; Heterochromatin; Histones; Humans; Lysine; Methylation; Methyltransferases; Mice; MicroRNAs; Nuclear Transfer Techniques; Repressor Proteins | 2017 |
Methylation of DNA Ligase 1 by G9a/GLP Recruits UHRF1 to Replicating DNA and Regulates DNA Methylation.
Topics: Animals; CCAAT-Enhancer-Binding Proteins; DNA; DNA Ligase ATP; DNA Methylation; DNA Replication; Embryonic Stem Cells; Epigenesis, Genetic; HEK293 Cells; HeLa Cells; Histocompatibility Antigens; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Mice; Models, Molecular; Molecular Mimicry; Mutation; Protein Binding; Protein Conformation; Protein Processing, Post-Translational; Structure-Activity Relationship; Transfection; Tudor Domain; Ubiquitin-Protein Ligases | 2017 |
PHF20 positively regulates osteoblast differentiation via increasing the expression and activation of Runx2 with enrichment of H3K4me3.
Topics: Animals; Cell Differentiation; Cells, Cultured; Core Binding Factor Alpha 1 Subunit; DNA-Binding Proteins; HEK293 Cells; Histones; Homeodomain Proteins; Humans; Lysine; Methylation; Mice; Osteoblasts; Osteogenesis; Promoter Regions, Genetic; Transcription Factors | 2017 |
Inhibition of EZH2 Promotes Human Embryonic Stem Cell Differentiation into Mesoderm by Reducing H3K27me3.
Topics: Cell Differentiation; Cell Lineage; Cellular Reprogramming; Enhancer of Zeste Homolog 2 Protein; Gene Ontology; Histones; Human Embryonic Stem Cells; Humans; Indoles; Lysine; Mesenchymal Stem Cells; Mesoderm; Methylation; Multigene Family; Pyridones; Transcriptome | 2017 |
Tudor-domain protein PHF20L1 reads lysine methylated retinoblastoma tumour suppressor protein.
Topics: Cell Cycle; Cell Line, Tumor; Chromosomal Proteins, Non-Histone; Genes, Tumor Suppressor; Histone Acetyltransferases; Humans; Lysine; MCF-7 Cells; Methylation; Retinoblastoma Protein; Transfection; Tumor Suppressor p53-Binding Protein 1 | 2017 |
Oocyte-derived histone H3 lysine 27 methylation controls gene expression in the early embryo.
Topics: Animals; Drosophila; Embryo, Mammalian; Gene Expression Regulation, Developmental; Genomic Imprinting; Histone Code; Histones; Lysine; Methylation; Mice; Oocytes | 2017 |
Lysine trimethylation regulates 78-kDa glucose-regulated protein proteostasis during endoplasmic reticulum stress.
Topics: Animals; Cell Line; DNA Modification Methylases; Endoplasmic Reticulum Chaperone BiP; Endoplasmic Reticulum Stress; Heat-Shock Proteins; Lysine; Methylation; Mice; Podocytes; Proteolysis; Unfolded Protein Response | 2017 |
Accumulation of histone variant H3.3 with age is associated with profound changes in the histone methylation landscape.
Topics: Aging; Animals; Carcinoma, Hepatocellular; Cells, Cultured; Hepatocytes; Histone Code; Histones; Humans; Liver Neoplasms; Lysine; Male; Methylation; Mice, Inbred C57BL; Protein Isoforms; Protein Processing, Post-Translational | 2017 |
Metabolically Derived Lysine Acylations and Neighboring Modifications Tune the Binding of the BET Bromodomains to Histone H4.
Topics: Acylation; Animals; Cell Cycle Proteins; Cell Line; Chickens; Histones; Ligands; Lysine; Methylation; Models, Molecular; Molecular Docking Simulation; Nuclear Proteins; Nucleosomes; Oligopeptides; Peptide Fragments; Phosphorylation; Protein Array Analysis; Protein Interaction Domains and Motifs; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases; Recombinant Fusion Proteins; RNA-Binding Proteins; Transcription Factors | 2017 |
Two-domain analysis of JmjN-JmjC and PHD-JmjC lysine demethylases: Detecting an inter-domain evolutionary stress.
Topics: Amino Acid Sequence; Databases, Protein; Histone Demethylases; Histones; Humans; Lysine; Methylation; Models, Molecular; Molecular Structure; Protein Domains; Sequence Alignment; Structure-Activity Relationship | 2018 |
Computational characterization of substrate and product specificities, and functionality of S-adenosylmethionine binding pocket in histone lysine methyltransferases from Arabidopsis, rice and maize.
Topics: Arabidopsis; Binding Sites; Catalysis; Databases, Protein; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Models, Chemical; Molecular Structure; Oryza; Plant Proteins; Protein Binding; Protein Conformation; Protein Processing, Post-Translational; S-Adenosylmethionine; Sequence Analysis, Protein; Substrate Specificity; Zea mays | 2018 |
Functional analysis of methyltransferases participating in streptothricin-related antibiotic biosynthesis.
Topics: Amino Acids; Anti-Bacterial Agents; Biosynthetic Pathways; Genes, Bacterial; Hydrolases; Lysine; Methylation; Methyltransferases; Multigene Family; Streptomyces; Streptothricins | 2018 |
Proteomic identification of histone post-translational modifications and proteins enriched at a DNA double-strand break.
Topics: Chromosomal Proteins, Non-Histone; DNA Breaks, Double-Stranded; DNA Repair; Histones; Lysine; Mass Spectrometry; Methylation; Nuclear Proteins; Protein Phosphatase 2; Protein Processing, Post-Translational; Proteome; Proteomics; RNA-Binding Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Ubiquitin-Protein Ligases | 2017 |
Transcription factor 19 interacts with histone 3 lysine 4 trimethylation and controls gluconeogenesis via the nucleosome-remodeling-deacetylase complex.
Topics: Cell Line; Epigenesis, Genetic; Gene Expression Regulation, Enzymologic; Gluconeogenesis; Hepatocytes; Histones; Humans; Lysine; Methylation; Mi-2 Nucleosome Remodeling and Deacetylase Complex; Models, Molecular; Molecular Docking Simulation; Mutagenesis, Site-Directed; Mutation; Peptide Fragments; Promoter Regions, Genetic; Protein Conformation; Protein Interaction Domains and Motifs; Protein Processing, Post-Translational; Protein Transport; Recombinant Proteins; Transcription Factors | 2017 |
UTX/KDM6A Loss Enhances the Malignant Phenotype of Multiple Myeloma and Sensitizes Cells to EZH2 inhibition.
Topics: Animals; Carcinogenesis; Cell Adhesion; Cell Dedifferentiation; Cell Line, Tumor; Cell Proliferation; Cell Survival; Clone Cells; Enhancer of Zeste Homolog 2 Protein; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Histone Demethylases; Histones; Indazoles; Interferon Regulatory Factors; Lysine; Methylation; Mice; Mice, Inbred NOD; Mice, SCID; Multiple Myeloma; Mutation; Nuclear Proteins; Phenotype; Pyridones; Transcription, Genetic | 2017 |
Lysine methylation signaling in pancreatic cancer.
Topics: Animals; Histone-Lysine N-Methyltransferase; Humans; Lysine; MAP Kinase Signaling System; Methylation; Pancreatic Neoplasms; Signal Transduction | 2018 |
The methyltransferase NSD3 promotes antiviral innate immunity via direct lysine methylation of IRF3.
Topics: Animals; Antiviral Agents; Cell Nucleus; HEK293 Cells; Histone-Lysine N-Methyltransferase; Humans; Immunity, Innate; Interferon Regulatory Factor-3; Lysine; Macrophages; Methylation; Mice, Inbred C57BL; Nuclear Proteins; Phosphoprotein Phosphatases; Phosphorylation; Protein Binding; Transcription, Genetic; Vesiculovirus | 2017 |
Rapid Communication: The correlation between histone modifications and expression of key genes involved in accumulation of adipose tissue in the pig.
Topics: Acetylation; Adipose Tissue; Animals; Epigenesis, Genetic; Gene Expression Regulation; Histone Code; Histones; Lysine; Methylation; Swine | 2017 |
Increased Post-Translational Lysine Acetylation of Myelin Basic Protein Is Associated with Peak Neurological Disability in a Mouse Experimental Autoimmune Encephalomyelitis Model of Multiple Sclerosis.
Topics: Acetylation; Animals; Encephalomyelitis, Autoimmune, Experimental; Histone Deacetylase Inhibitors; Hydroxamic Acids; Lysine; Methylation; Mice; Multiple Sclerosis; Myelin Basic Protein; Nervous System Diseases; Protein Processing, Post-Translational | 2018 |
NSD3 keeps IRF3 active.
Topics: Antiviral Agents; Immunity, Innate; Interferon Regulatory Factor-3; Lysine; Methylation; Methyltransferases | 2017 |
H4K20me2 distinguishes pre-replicative from post-replicative chromatin to appropriately direct DNA repair pathway choice by 53BP1-RIF1-MAD2L2.
Topics: BRCA1 Protein; Chromatin; Cyclin-Dependent Kinases; DNA Breaks, Double-Stranded; DNA Repair; DNA Replication; G2 Phase; HeLa Cells; Histones; Humans; Lysine; Mad2 Proteins; Methylation; Models, Biological; Protein Binding; Telomere-Binding Proteins; Tumor Suppressor p53-Binding Protein 1 | 2018 |
Shoring up DNA methylation and H3K27me3 domain demarcation at developmental genes.
Topics: DNA Methylation; Genes, Developmental; Histones; Lysine; Methylation | 2017 |
Topics: Arabidopsis; Arabidopsis Proteins; Cell Dedifferentiation; Epigenesis, Genetic; Gene Expression Regulation, Plant; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Mutation; Promoter Regions, Genetic; Transcription Factors | 2017 |
Investigating d-lysine stereochemistry for epigenetic methylation, demethylation and recognition.
Topics: Biocatalysis; Epigenesis, Genetic; Histone Demethylases; Lysine; Methylation; Methyltransferases; Models, Molecular; Molecular Conformation; Stereoisomerism; Thermodynamics | 2017 |
Linking PHYTOCHROME-INTERACTING FACTOR to Histone Modification in Plant Shade Avoidance.
Topics: Acetylation; Arabidopsis; Arabidopsis Proteins; Chromatin; Chromosomal Proteins, Non-Histone; DNA-Binding Proteins; Gene Expression Regulation, Plant; Histones; Hypocotyl; Lysine; Methylation; Plants, Genetically Modified | 2018 |
SnapShot: Lysine Methylation beyond Histones.
Topics: Animals; Histones; Humans; Lysine; Methylation; Protein Processing, Post-Translational; Signal Transduction | 2017 |
Structure of the Arabidopsis JMJ14-H3K4me3 Complex Provides Insight into the Substrate Specificity of KDM5 Subfamily Histone Demethylases.
Topics: Amino Acid Sequence; Arabidopsis Proteins; Catalytic Domain; Conserved Sequence; Histone Demethylases; Histones; Humans; Jumonji Domain-Containing Histone Demethylases; Lysine; Methylation; Nuclear Proteins; Peptides; Protein Binding; Protein Domains; Repressor Proteins; Substrate Specificity | 2018 |
Circular dichroism spectroscopic study on structural alterations of histones induced by post-translational modifications in DNA damage responses: lysine-9 methylation of H3.
Topics: Amino Acid Sequence; Animals; Circular Dichroism; DNA Damage; Histones; Humans; Lysine; Methylation; Protein Processing, Post-Translational; Protein Structure, Secondary; Solutions; Xenopus laevis | 2018 |
Independence between pre-mRNA splicing and DNA methylation in an isogenic minigene resource.
Topics: Animals; Chromatin; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Methyltransferase 3B; Exons; Gene Expression Regulation; HEK293 Cells; Histones; Humans; Lysine; Methylation; Mice; Models, Genetic; RNA Precursors; RNA Splicing | 2017 |
Trithorax-group proteins ARABIDOPSIS TRITHORAX4 (ATX4) and ATX5 function in abscisic acid and dehydration stress responses.
Topics: Abscisic Acid; Arabidopsis; Arabidopsis Proteins; Dehydration; Droughts; Gene Expression Regulation, Plant; Genetic Loci; Histone-Lysine N-Methyltransferase; Histones; Loss of Function Mutation; Lysine; Methylation; Organ Specificity; Plant Development; Stress, Physiological; Transcription, Genetic | 2018 |
Asymmetrical changes of gene expression, small RNAs and chromatin in two resynthesized wheat allotetraploids.
Topics: Chromatin; Chromosomes, Plant; Endosperm; Gene Expression Regulation, Plant; Genome, Plant; Histones; Lysine; Methylation; Plant Roots; RNA, Messenger; RNA, Small Interfering; Tetraploidy; Triticum | 2018 |
[Distributions of H3K27me3 and its modification enzymes in different tissues of mice].
Topics: Age Factors; Animals; Animals, Newborn; Enhancer of Zeste Homolog 2 Protein; Gene Expression Profiling; Gene Expression Regulation, Enzymologic; Histone Demethylases; Histones; Immunohistochemistry; Jumonji Domain-Containing Histone Demethylases; Lysine; Male; Methylation; Mice, Inbred C57BL; Reverse Transcriptase Polymerase Chain Reaction | 2017 |
Set2 methyltransferase facilitates cell cycle progression by maintaining transcriptional fidelity.
Topics: Anaphase-Promoting Complex-Cyclosome; Biological Evolution; Cdc20 Proteins; Cell Cycle; Gene Expression Regulation, Fungal; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Methyltransferases; Nocodazole; Protein Processing, Post-Translational; Proteolysis; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Transcription, Genetic; Tubulin Modulators | 2018 |
Histone demethylase KDM5A inhibits glioma cells migration and invasion by down regulating ZEB1.
Topics: Biocatalysis; Biomarkers, Tumor; Cell Line, Tumor; Cell Movement; Down-Regulation; Epithelial-Mesenchymal Transition; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Glioma; Histones; Humans; Lysine; Methylation; Neoplasm Invasiveness; Neoplasm Metastasis; Promoter Regions, Genetic; Retinoblastoma-Binding Protein 2; Zinc Finger E-box-Binding Homeobox 1 | 2018 |
A Non-canonical BCOR-PRC1.1 Complex Represses Differentiation Programs in Human ESCs.
Topics: Cell Differentiation; Chromatin; F-Box Proteins; Histones; Human Embryonic Stem Cells; Humans; Jumonji Domain-Containing Histone Demethylases; Lysine; Methylation; Multiprotein Complexes; Polycomb Repressive Complex 1; Polycomb Repressive Complex 2; Promoter Regions, Genetic; Protein Domains; Proto-Oncogene Proteins; Repressor Proteins | 2018 |
Canonical and Noncanonical Actions of Arabidopsis Histone Deacetylases in Ribosomal RNA Processing.
Topics: Acetylation; Amino Acid Sequence; Arabidopsis; Arabidopsis Proteins; Base Sequence; Gene Deletion; Genes, Plant; Genetic Pleiotropy; Histone Deacetylases; Histones; Lysine; Methylation; Models, Biological; Nicotiana; Organelle Biogenesis; Plants, Genetically Modified; Promoter Regions, Genetic; Protein Binding; Ribosomes; RNA Precursors; RNA Processing, Post-Transcriptional; RNA, Ribosomal; RNA, Small Nucleolar | 2018 |
Role of METTL20 in regulating β-oxidation and heat production in mice under fasting or ketogenic conditions.
Topics: Animals; Catalysis; CRISPR-Cas Systems; Electron-Transferring Flavoproteins; Fasting; Fatty Acids; Gene Editing; Humans; Ketone Bodies; Loss of Function Mutation; Lysine; Metabolomics; Methylation; Methyltransferases; Mice; Mice, Knockout; Mitochondria; Oxidation-Reduction; Oxygen Consumption; Substrate Specificity; Thermogenesis | 2018 |
Mitochondrial translation requires folate-dependent tRNA methylation.
Topics: Aminohydrolases; Biocatalysis; Carrier Proteins; Codon; Electron Transport; Folic Acid; Folic Acid Antagonists; Glycine Hydroxymethyltransferase; GTP-Binding Proteins; Guanosine; HCT116 Cells; HEK293 Cells; Humans; Leucine; Lysine; Methylation; Methylenetetrahydrofolate Dehydrogenase (NADP); Mitochondria; Multifunctional Enzymes; Oxidative Phosphorylation; Protein Biosynthesis; Ribosomes; RNA-Binding Proteins; RNA, Transfer; Sarcosine; Tetrahydrofolates; Thymine Nucleotides | 2018 |
Identification of protein lysine methylation readers with a yeast three-hybrid approach.
Topics: Animals; Cell Line; Chromobox Protein Homolog 5; Chromosomal Proteins, Non-Histone; Cloning, Molecular; Epigenesis, Genetic; Gene Library; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Mice; Phosphoproteins; Protein Processing, Post-Translational; Two-Hybrid System Techniques | 2018 |
Loss of ATRX suppresses ATM dependent DNA damage repair by modulating H3K9me3 to enhance temozolomide sensitivity in glioma.
Topics: Animals; Antineoplastic Agents, Alkylating; Ataxia Telangiectasia Mutated Proteins; Brain Neoplasms; Cell Line, Tumor; Cell Survival; DNA Damage; DNA Repair; Female; Gene Expression Regulation, Neoplastic; Gene Knockout Techniques; Glioma; Histones; Humans; Lysine; Methylation; Mice, Nude; Temozolomide; X-linked Nuclear Protein; Xenograft Model Antitumor Assays | 2018 |
The histone demethylase Jmjd3 regulates zebrafish myeloid development by promoting spi1 expression.
Topics: Animals; Animals, Genetically Modified; Cell Differentiation; Embryo, Nonmammalian; Gene Expression Regulation, Developmental; Gene Knockdown Techniques; Histones; Jumonji Domain-Containing Histone Demethylases; Lysine; Methylation; Myeloid Cells; Myelopoiesis; Proto-Oncogene Proteins; Trans-Activators; Zebrafish; Zebrafish Proteins | 2018 |
Dynamic regulation of six histone H3 lysine (K) methyltransferases in response to prolonged anoxia exposure in a freshwater turtle.
Topics: Animals; Fresh Water; Gene Expression Regulation; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Hypoxia; Liver; Lysine; Methylation; Methyltransferases; Oxygen; Protein Processing, Post-Translational; Turtles | 2018 |
A liquid chromatography tandem mass spectroscopy approach for quantification of protein methylation stoichiometry.
Topics: Animals; Arginine; Cattle; Chromatography, Liquid; Humans; Lysine; Methylation; Proteins; Tandem Mass Spectrometry | 2018 |
Contrasting roles of H3K4me3 and H3K9me3 in regulation of apoptosis and gemcitabine resistance in human pancreatic cancer cells.
Topics: Antimetabolites, Antineoplastic; Apoptosis; Apoptosis Regulatory Proteins; Carcinoma, Pancreatic Ductal; Cell Line, Tumor; Deoxycytidine; Drug Resistance, Neoplasm; Epigenesis, Genetic; Gemcitabine; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Humans; Indoles; Lysine; Methylation; Pancreatic Neoplasms | 2018 |
Epigenetic alterations contribute to promoter activity of imprinting gene IGF2.
Topics: Carcinoma, Hepatocellular; Cell Line, Tumor; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Genomic Imprinting; Hep G2 Cells; Histone-Lysine N-Methyltransferase; Histones; Humans; Insulin-Like Growth Factor II; Liver Neoplasms; Lysine; Methylation; Myeloid-Lymphoid Leukemia Protein; Promoter Regions, Genetic; Proto-Oncogene Proteins | 2018 |
Tandem Histone-Binding Domains Enhance the Activity of a Synthetic Chromatin Effector.
Topics: Chromatin; Gene Expression Regulation; Gene Silencing; HEK293 Cells; Histones; Humans; Ligands; Lysine; Methylation; Models, Molecular; Polycomb-Group Proteins; Protein Binding; Protein Domains; Recombinant Fusion Proteins; Transcription Factors; Transcription, Genetic | 2018 |
Region specific knock-out reveals distinct roles of chromatin modifiers in adult neurogenic niches.
Topics: Aging; Animals; Cell Differentiation; Cell Movement; Chromatin; Enhancer of Zeste Homolog 2 Protein; Gene Knockout Techniques; Histone-Lysine N-Methyltransferase; Histones; Homologous Recombination; Integrases; Lysine; Methylation; Mice; Neurogenesis; Neurons; Organ Specificity; Recombinant Proteins; S Phase | 2018 |
Targeting the Senescence-Overriding Cooperative Activity of Structurally Unrelated H3K9 Demethylases in Melanoma.
Topics: Animals; Histone Demethylases; Histones; Humans; Jumonji Domain-Containing Histone Demethylases; Lysine; Melanoma; Methylation; Mice, Nude; Promoter Regions, Genetic | 2018 |
Regulation of eukaryotic elongation factor 1 alpha (eEF1A) by dynamic lysine methylation.
Topics: Actin Cytoskeleton; Eukaryotic Initiation Factor-1; Histone-Lysine N-Methyltransferase; Humans; Lysine; Methylation; Models, Molecular; Protein Conformation; Protein Processing, Post-Translational; Virus Replication | 2018 |
UV-B radiation delays flowering time through changes in the PRC2 complex activity and miR156 levels in Arabidopsis thaliana.
Topics: Arabidopsis; Arabidopsis Proteins; Down-Regulation; Flowers; Gene Expression Regulation, Plant; Genes, Plant; Histones; Lysine; Methylation; MicroRNAs; Mutation; Polycomb Repressive Complex 2; Repressor Proteins; Time Factors; Ultraviolet Rays | 2018 |
DZNep inhibits H3K27me3 deposition and delays retinal degeneration in the rd1 mice.
Topics: Adenosine; Amino Acid Motifs; Animals; Calpain; Disease Models, Animal; Epigenesis, Genetic; Female; Histones; Humans; Lysine; Male; Methylation; Mice; Mice, Inbred ICR; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Retina; Retinal Degeneration | 2018 |
Inhibition of the Histone H3K27 Demethylase UTX Enhances Tumor Cell Radiosensitivity.
Topics: A549 Cells; Benzazepines; Cell Line; Cell Line, Tumor; Cell Survival; DNA Breaks, Double-Stranded; DNA Repair; Histone Demethylases; Histones; Humans; Lysine; Methylation; Nuclear Proteins; Pyrimidines; Radiation Tolerance; RNA Interference | 2018 |
Nap1l1 Controls Embryonic Neural Progenitor Cell Proliferation and Differentiation in the Developing Brain.
Topics: Animals; Brain; Cell Differentiation; Cell Proliferation; Cerebral Cortex; Female; Gene Deletion; Gene Expression Regulation, Developmental; Gene Silencing; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Mice, Inbred ICR; Mice, Knockout; Mitosis; Neural Stem Cells; Neurogenesis; Nucleosome Assembly Protein 1; Promoter Regions, Genetic | 2018 |
Erythropoietin Upregulates Brain Hemoglobin Expression and Supports Neuronal Mitochondrial Activity.
Topics: Animals; Aspartic Acid; Brain; Cell Respiration; Cuprizone; Disease Models, Animal; Electron Transport Complex III; Erythropoietin; Hemoglobins; Histones; Lysine; Male; Methylation; Mice, Inbred C57BL; Mitochondria; Models, Biological; Multiple Sclerosis; Myelin Basic Protein; Myelin Sheath; Neurons; Up-Regulation | 2018 |
SETD7 Drives Cardiac Lineage Commitment through Stage-Specific Transcriptional Activation.
Topics: Calcium Signaling; Cell Differentiation; Cell Line; Cell Lineage; Chromatin; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Mesoderm; Methylation; Myocardium; Myocytes, Cardiac; RNA Polymerase II; Transcription, Genetic; Transcriptional Activation | 2018 |
Consequences of early life stress on genomic landscape of H3K4me3 in prefrontal cortex of adult mice.
Topics: Adaptation, Psychological; Animals; Behavior, Animal; Emotions; Female; Genomics; Histones; Lysine; Male; Maternal Deprivation; Methylation; Mice; Mice, Inbred C57BL; Prefrontal Cortex; Stress, Psychological | 2018 |
Signaling function of PRC2 is essential for TCR-driven T cell responses.
Topics: Animals; Autoimmunity; Cell Proliferation; Cytoplasm; Enhancer of Zeste Homolog 2 Protein; Extracellular Signal-Regulated MAP Kinases; Gene Expression Regulation; Histones; Interleukin-2; Lymphocyte Subsets; Lysine; Methylation; Mice; Phosphorylation; Polycomb Repressive Complex 2; Receptors, Antigen, T-Cell; Receptors, Interleukin-2; Signal Transduction; T-Lymphocytes; Transcription, Genetic | 2018 |
Combined Loss of JMJD1A and JMJD1B Reveals Critical Roles for H3K9 Demethylation in the Maintenance of Embryonic Stem Cells and Early Embryogenesis.
Topics: Animals; Cell Cycle Checkpoints; Cell Line; Cell Survival; Chromosomes, Mammalian; Demethylation; Down-Regulation; Embryonic Development; Gene Expression Regulation, Developmental; Histone-Lysine N-Methyltransferase; Histones; Jumonji Domain-Containing Histone Demethylases; Lysine; Methylation; Mice; Mouse Embryonic Stem Cells; Mutation | 2018 |
Increased H3K9 methylation and impaired expression of Protocadherins are associated with the cognitive dysfunctions of the Kleefstra syndrome.
Topics: Animals; Animals, Newborn; Cadherins; Chromosome Deletion; Chromosomes, Human, Pair 9; Cognitive Dysfunction; Craniofacial Abnormalities; Disease Models, Animal; Gene Expression Regulation; Heart Defects, Congenital; Hippocampus; Histone-Lysine N-Methyltransferase; Histones; Intellectual Disability; Lysine; Male; Methylation; Mice, Knockout | 2018 |
H3K4 Methylation Dependent and Independent Chromatin Regulation by
Topics: Alleles; Chromatin; Gene Deletion; Gene Expression Regulation, Fungal; Histone-Lysine N-Methyltransferase; Histones; Jumonji Domain-Containing Histone Demethylases; Lysine; Methylation; Models, Genetic; Nucleosomes; Protein Subunits; Saccharomyces cerevisiae Proteins; Saccharomycetales; Suppression, Genetic; Temperature; Transcription Initiation Site | 2018 |
Crosstalk between lysine methylation and phosphorylation of ATG16L1 dictates the apoptosis of hypoxia/reoxygenation-induced cardiomyocytes.
Topics: Amino Acid Sequence; Animals; Apoptosis; Autophagy; Autophagy-Related Proteins; Carrier Proteins; Cell Hypoxia; HEK293 Cells; Histone Demethylases; Histone-Lysine N-Methyltransferase; Humans; Lysine; Methylation; Mice; Myocytes, Cardiac; Oxygen; Phosphorylation; Protein Binding; Protein Methyltransferases; Rats; Vesicular Transport Proteins | 2018 |
Histone H3 lysine 36 methyltransferase mobilizes NER factors to regulate tolerance against alkylation damage in fission yeast.
Topics: Alkylating Agents; Checkpoint Kinase 1; DNA Helicases; DNA Repair; DNA-Binding Proteins; Epistasis, Genetic; Gene Expression Regulation, Fungal; Histone-Lysine N-Methyltransferase; Lysine; Methyl Methanesulfonate; Methylation; Protein Domains; Schizosaccharomyces; Schizosaccharomyces pombe Proteins | 2018 |
Potent antitumor efficacy of anti-GD2 CAR T cells in H3-K27M
Topics: Animals; Brain Neoplasms; Gangliosides; Glioma; Histones; Humans; Immunotherapy, Adoptive; Lysine; Methylation; Mice; Receptors, Antigen, T-Cell; Xenograft Model Antitumor Assays | 2018 |
Integrative analysis reveals functional and regulatory roles of H3K79me2 in mediating alternative splicing.
Topics: Alternative Splicing; Cell Line, Tumor; Cluster Analysis; Exons; Gene Expression Regulation, Neoplastic; Gene Ontology; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Methyltransferases; Neoplasms; Nucleotide Motifs; Reproducibility of Results; RNA Splice Sites | 2018 |
Cucurbit[7]uril-Dimethyllysine Recognition in a Model Protein.
Topics: Bridged-Ring Compounds; Crystallography, X-Ray; Imidazoles; Lysine; Methylation; Models, Molecular; Proteins; Water | 2018 |
Distinct Stimulatory Mechanisms Regulate the Catalytic Activity of Polycomb Repressive Complex 2.
Topics: Animals; Catalysis; Cell Line; Chromatin; DNA-Binding Proteins; Enhancer of Zeste Homolog 2 Protein; HEK293 Cells; Histones; Humans; Lysine; Methylation; Mice; Polycomb Repressive Complex 2 | 2018 |
Interactions of HP1 Bound to H3K9me3 Dinucleosome by Molecular Simulations and Biochemical Assays.
Topics: Amino Acid Sequence; Chromobox Protein Homolog 5; Chromosomal Proteins, Non-Histone; Histones; Lysine; Methylation; Molecular Dynamics Simulation; Nucleosomes; Protein Binding; Protein Conformation | 2018 |
Histone H3.3 G34 Mutations Alter Histone H3K36 and H3K27 Methylation In Cis.
Topics: Bone Neoplasms; Brain Neoplasms; Child; Epigenesis, Genetic; Giant Cell Tumor of Bone; Glioblastoma; HeLa Cells; Histones; Humans; Lysine; Methylation; Mutation | 2018 |
Topics: Animals; Carcinogenesis; Carcinoma, Renal Cell; Cell Line, Tumor; Chromosomes, Human, Pair 3; Fibroblasts; Gene Knockdown Techniques; Genomic Instability; Haploinsufficiency; Histone-Lysine N-Methyltransferase; Histones; Humans; Kidney Neoplasms; Kidney Tubules, Proximal; Lysine; Methylation; Mice; Micronuclei, Chromosome-Defective; Microtubules | 2018 |
Depletion of Nsd2-mediated histone H3K36 methylation impairs adipose tissue development and function.
Topics: 3T3-L1 Cells; Adipocytes; Adipogenesis; Adipose Tissue, Brown; Adipose Tissue, White; Animals; Cell Line; Gene Expression Regulation; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Mice; Mice, Inbred C57BL; Mice, Transgenic; Mutation; PPAR gamma | 2018 |
Identification of methylated tubulin through analysis of methylated lysine.
Topics: Chemistry Techniques, Analytical; Chromatography; Histones; Limit of Detection; Lysine; Methylation; Protein Processing, Post-Translational; Tubulin | 2018 |
The Legionella pneumophila Methyltransferase RomA Methylates Also Non-histone Proteins during Infection.
Topics: Bacterial Proteins; Cloning, Molecular; HEK293 Cells; HeLa Cells; Histone-Lysine N-Methyltransferase; Humans; Legionella pneumophila; Legionnaires' Disease; Lysine; Methylation; Nuclear Proteins; Peptides; Protein Processing, Post-Translational; Substrate Specificity; Transcription Factors | 2018 |
Design, Synthesis, and In Vitro Evaluation of Novel Histone H3 Peptide-Based LSD1 Inactivators Incorporating α,α-Disubstituted Amino Acids with γ-Turn-Inducing Structures.
Topics: Amino Acids; Amino Acids, Cyclic; Catalytic Domain; Cyclohexanecarboxylic Acids; Drug Design; Enzyme Assays; Enzyme Inhibitors; Histone Demethylases; Histones; Humans; Hydrolysis; Isoenzymes; Lysine; Methylation; Molecular Docking Simulation; Monoamine Oxidase; Peptides; Protein Binding; Protein Interaction Domains and Motifs; Protein Structure, Secondary; Structure-Activity Relationship; Tranylcypromine | 2018 |
JMJD3 inhibition protects against isoproterenol-induced cardiac hypertrophy by suppressing β-MHC expression.
Topics: Animals; Animals, Newborn; Benzazepines; Cardiomegaly; Demethylation; Gene Knockdown Techniques; Histones; Isoproterenol; Jumonji Domain-Containing Histone Demethylases; Lysine; Male; Methylation; Mice, Inbred C57BL; Myocytes, Cardiac; Myosin Heavy Chains; Promoter Regions, Genetic; Pyrimidines; Rats, Sprague-Dawley; Up-Regulation | 2018 |
Methionine metabolism influences genomic architecture and gene expression through H3K4me3 peak width.
Topics: Animals; Gene Expression Profiling; Genomics; HCT116 Cells; Histone Code; Histones; Humans; Liver; Lysine; Male; Methionine; Methylation; Mice, Inbred C57BL; Neoplasms | 2018 |
Enhancer of zeste homolog 2-catalysed H3K27 trimethylation plays a key role in acute-on-chronic liver failure via TNF-mediated pathway.
Topics: Acute-On-Chronic Liver Failure; Animals; Biocatalysis; Chromatin; Cytokines; Disease Models, Animal; Enhancer of Zeste Homolog 2 Protein; Female; Histones; Humans; Indoles; Inflammation Mediators; Kupffer Cells; Lipopolysaccharides; Liver; Lysine; Methylation; Mice, Inbred C57BL; NF-kappa B; Promoter Regions, Genetic; Proto-Oncogene Proteins c-akt; Pyridones; Signal Transduction; Tumor Necrosis Factor-alpha | 2018 |
The Memory of Environmental Chemical Exposure in C. elegans Is Dependent on the Jumonji Demethylases jmjd-2 and jmjd-3/utx-1.
Topics: Animals; Benzhydryl Compounds; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Embryo, Nonmammalian; Environment; Fertility; Germ Cells; Histone Code; Histone Demethylases; Histones; Inheritance Patterns; Lysine; Memory; Methylation; Phenols; Transcriptome; Transgenes; Up-Regulation | 2018 |
H3K27me1 is essential for MMP-9-dependent H3N-terminal tail proteolysis during osteoclastogenesis.
Topics: Chromatin; Epigenesis, Genetic; HEK293 Cells; Histocompatibility Antigens; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Matrix Metalloproteinase 9; Methylation; Osteoclasts; Osteogenesis; Proteolysis; RANK Ligand | 2018 |
Methylation of hypoxia-inducible factor (HIF)-1α by G9a/GLP inhibits HIF-1 transcriptional activity and cell migration.
Topics: Autoantigens; Cell Hypoxia; Cell Line; Cell Movement; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Glioblastoma; Golgi Matrix Proteins; Histocompatibility Antigens; Histone-Lysine N-Methyltransferase; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Lysine; Methylation; Response Elements; Transcription, Genetic | 2018 |
Cell Lysate Microarray for Mapping the Network of Genetic Regulators for Histone Marks.
Topics: Acyl Coenzyme A; Acylation; Click Chemistry; Gene Regulatory Networks; Histone Code; Histones; Lysine; Methylation; Models, Biological; Mutation; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Stress, Physiological | 2018 |
Unique patterns of trimethylation of histone H3 lysine 4 are prone to changes during aging in Caenorhabditis elegans somatic cells.
Topics: Age Factors; Animals; Caenorhabditis elegans; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation; Histones; Lysine; Methylation; Transcriptional Activation | 2018 |
Distinct functions of polycomb group proteins in regulating Ci transcription in developing Drosophila.
Topics: Animals; Animals, Genetically Modified; DNA-Binding Proteins; Drosophila melanogaster; Drosophila Proteins; Epigenesis, Genetic; Gene Expression Regulation, Developmental; Homeodomain Proteins; Lysine; Methylation; Mutation; Nuclear Proteins; Polycomb Repressive Complex 1; Polycomb Repressive Complex 2; Protein Domains; Transcription Factors; Transcription, Genetic | 2018 |
Epigenetic inheritance mediated by coupling of RNAi and histone H3K9 methylation.
Topics: Alleles; Cell Cycle Proteins; Epigenomics; Feedback, Physiological; Genes, Fungal; Heterochromatin; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Methyltransferases; Nuclear Proteins; RNA Interference; Schizosaccharomyces; Schizosaccharomyces pombe Proteins | 2018 |
The Ubx Polycomb response element bypasses an unpaired Fab-8 insulator via cis transvection in Drosophila.
Topics: Animals; Animals, Genetically Modified; CCCTC-Binding Factor; Chromatin; Chromosomes, Insect; Drosophila melanogaster; Drosophila Proteins; Embryo, Nonmammalian; Genes, Reporter; Heterozygote; Histones; Homeodomain Proteins; Homozygote; Insulator Elements; Lysine; Methylation; Models, Biological; Phenotype; Promoter Regions, Genetic; Response Elements; RNA Polymerase II; Transcription Factors; Transgenes | 2018 |
An outlook on lysine methylation of non-histone proteins in plants.
Topics: Chromosomal Proteins, Non-Histone; Lysine; Methylation; Plant Proteins | 2018 |
Capturing the Onset of PRC2-Mediated Repressive Domain Formation.
Topics: Animals; Chromatin; Gene Silencing; Histone Code; Histones; Lysine; Methylation; Mice; Mice, Inbred C57BL; Mouse Embryonic Stem Cells; Polycomb Repressive Complex 2; Polycomb-Group Proteins; Protein Binding; Protein Processing, Post-Translational | 2018 |
Postnatal changes in epigenetic modifications of neutrophils of foals are associated with increased ROS function and regulation of neutrophil function.
Topics: Animals; Animals, Newborn; Cytokines; Epigenesis, Genetic; Histones; Horse Diseases; Horses; Immunity, Innate; Lysine; Methylation; Neutrophils; Promoter Regions, Genetic; Reactive Oxygen Species; Signal Transduction | 2018 |
Regulation of Breast Cancer-Induced Osteoclastogenesis by MacroH2A1.2 Involving EZH2-Mediated H3K27me3.
Topics: Animals; Bone Resorption; Breast Neoplasms; Cell Differentiation; Cell Line, Tumor; Enhancer of Zeste Homolog 2 Protein; Female; Gene Expression Regulation, Neoplastic; Histones; Humans; Lysine; Methylation; Mice, Inbred C57BL; Nucleosomes; Osteoclasts; Osteogenesis; Phosphorylation; Protein Binding; Protein-Lysine 6-Oxidase; Proto-Oncogene Proteins pp60(c-src) | 2018 |
Molecular basis for the inhibition of the methyl-lysine binding function of 53BP1 by TIRR.
Topics: Binding, Competitive; Carrier Proteins; Crystallography, X-Ray; DNA; DNA Breaks, Double-Stranded; DNA Damage; DNA Repair; HEK293 Cells; Histones; Humans; Lysine; Methylation; Mutation; Protein Binding; RNA-Binding Proteins; Tumor Suppressor p53-Binding Protein 1 | 2018 |
SET1A-Mediated Mono-Methylation at K342 Regulates YAP Activation by Blocking Its Nuclear Export and Promotes Tumorigenesis.
Topics: A549 Cells; Active Transport, Cell Nucleus; Adaptor Proteins, Signal Transducing; Animals; Cell Cycle Proteins; Cell Nucleus; Cell Proliferation; Cell Transformation, Neoplastic; Colorectal Neoplasms; HEK293 Cells; HeLa Cells; Histone-Lysine N-Methyltransferase; Humans; Lung Neoplasms; Lysine; Methylation; Mice, Inbred C57BL; Mice, Knockout; Phosphoproteins; Prognosis; Protein Binding; Protein Interaction Domains and Motifs; Protein Processing, Post-Translational; Signal Transduction; Transcription Factors; Tumor Burden; YAP-Signaling Proteins | 2018 |
RNA Sequencing and Pathway Analysis Identify Important Pathways Involved in Hypertrichosis and Intellectual Disability in Patients with Wiedemann-Steiner Syndrome.
Topics: Adolescent; Adult; Child; Female; Fibroblasts; Gene Expression Regulation; Histone-Lysine N-Methyltransferase; Histones; Humans; Hypertrichosis; Intellectual Disability; Loss of Function Mutation; Lysine; Male; Methylation; Middle Aged; Myeloid-Lymphoid Leukemia Protein; Nitric Oxide Synthase Type III; Rare Diseases; Sequence Analysis, RNA; Signal Transduction; Syndrome; Transcription, Genetic; Young Adult | 2018 |
iAcet-Sumo: Identification of lysine acetylation and sumoylation sites in proteins by multi-class transformation methods.
Topics: Acetylation; Databases, Protein; Lysine; Methylation; Sequence Analysis, Protein; Software; Sumoylation; Ubiquitinated Proteins | 2018 |
TSPYL2 Regulates the Expression of EZH2 Target Genes in Neurons.
Topics: Animals; Cell Cycle Proteins; Enhancer of Zeste Homolog 2 Protein; Gene Expression Regulation; Gene Ontology; HEK293 Cells; Histones; Humans; Lysine; Male; Methylation; Mice; Models, Genetic; Neurons; Nuclear Proteins; Promoter Regions, Genetic; Protein Binding; Transcription, Genetic | 2019 |
Histone demethylase KDM2B promotes triple negative breast cancer proliferation by suppressing p15INK4B, p16INK4A, and p57KIP2 transcription.
Topics: Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p15; Cyclin-Dependent Kinase Inhibitor p16; Cyclin-Dependent Kinase Inhibitor p57; F-Box Proteins; Gene Expression Regulation, Neoplastic; Histones; Humans; Jumonji Domain-Containing Histone Demethylases; Lysine; Methylation; Promoter Regions, Genetic; Protein Binding; RNA Interference; Triple Negative Breast Neoplasms | 2018 |
Inhibitor of CBP Histone Acetyltransferase Downregulates p53 Activation and Facilitates Methylation at Lysine 27 on Histone H3.
Topics: Acetylation; Animals; Apoptosis; Cell Line, Tumor; Cell Proliferation; Chromatin; CREB-Binding Protein; Curcumin; DNA Damage; Down-Regulation; Drug Evaluation, Preclinical; Enterocytes; Enzyme Inhibitors; Histones; Humans; Inhibitory Concentration 50; Lysine; Methylation; Protein Domains; Rats; Structure-Activity Relationship; Tumor Suppressor Protein p53 | 2018 |
Canonical PRC2 function is essential for mammary gland development and affects chromatin compaction in mammary organoids.
Topics: Animals; Chromatin; Enhancer of Zeste Homolog 2 Protein; Female; Heterochromatin; Histone Code; Histones; Lysine; Mammary Glands, Animal; Methylation; Mice; Polycomb Repressive Complex 2; Polycomb-Group Proteins; Primary Cell Culture; Protein Processing, Post-Translational | 2018 |
Prognostic value of histone marks H3K27me3 and H3K9me3 and modifying enzymes EZH2, SETDB1 and LSD-1 in colorectal cancer.
Topics: Aged; Biomarkers, Tumor; Colorectal Neoplasms; Enhancer of Zeste Homolog 2 Protein; Female; Histone Demethylases; Histone-Lysine N-Methyltransferase; Histones; Humans; Immunohistochemistry; Kaplan-Meier Estimate; Lysine; Male; Methylation; Middle Aged; Prognosis; Protein Methyltransferases; Retrospective Studies | 2018 |
The tumor suppressor menin prevents effector CD8 T-cell dysfunction by targeting mTORC1-dependent metabolic activation.
Topics: Activation, Metabolic; Animals; Carbon; CD8-Positive T-Lymphocytes; Cell Proliferation; Female; Glutamine; Histones; Ketoglutaric Acids; Lymphocyte Activation; Lysine; Mechanistic Target of Rapamycin Complex 1; Metabolomics; Methylation; Mice, Inbred C57BL; Mice, Knockout; Proto-Oncogene Proteins; Sirolimus | 2018 |
Mechanistic insights into plant SUVH family H3K9 methyltransferases and their binding to context-biased non-CG DNA methylation.
Topics: Arabidopsis; Arabidopsis Proteins; Base Sequence; Crystallography, X-Ray; DNA; DNA Methylation; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Models, Molecular; Nucleic Acid Conformation; Plants, Genetically Modified; Protein Binding; Protein Conformation | 2018 |
Interactive and noninteractive roles of histone H2B monoubiquitination and H3K36 methylation in the regulation of active gene transcription and control of plant growth and development.
Topics: Arabidopsis; Arabidopsis Proteins; Chromatin; Flowers; Gene Expression Profiling; Gene Expression Regulation, Developmental; Gene Expression Regulation, Plant; Histone Code; Histones; Lysine; Methylation; Mutation; Nucleotide Motifs; Transcription, Genetic; Ubiquitination | 2019 |
Short-Term Mitochondrial Permeability Transition Pore Opening Modulates Histone Lysine Methylation at the Early Phase of Somatic Cell Reprogramming.
Topics: Animals; Cellular Reprogramming; Fibroblasts; HEK293 Cells; Histone Demethylases; Histones; Humans; Ketoglutaric Acids; Lysine; Methylation; Mice; Mice, Inbred C57BL; MicroRNAs; Mitochondria; Mitochondrial Membrane Transport Proteins; Mitochondrial Membranes; Mitochondrial Permeability Transition Pore; Mouse Embryonic Stem Cells; Reactive Oxygen Species; Transcription Factors | 2018 |
Multiple Histone Methyl-Lysine Readers Ensure Robust Development and Germline Immortality in
Topics: Amino Acid Sequence; Animals; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Fertility; Heterochromatin; Histones; Longevity; Lysine; Male; Methylation; Protein Domains; Spermatozoa; Temperature | 2018 |
Oligomerization and Auto-methylation of the Human Lysine Methyltransferase SETD6.
Topics: Gene Expression Regulation, Enzymologic; HEK293 Cells; Humans; Lysine; Methylation; Models, Molecular; Molecular Weight; Oxidative Stress; Point Mutation; Protein Conformation; Protein Methyltransferases; Protein Multimerization; S-Adenosylmethionine | 2018 |
Epigenetic markers in basal cell carcinoma: universal themes in oncogenesis and tumor stratification? - a short report.
Topics: 5-Methylcytosine; Carcinogenesis; Carcinoma, Basal Cell; Epigenesis, Genetic; Histones; Humans; Lysine; Methylation; Skin Neoplasms | 2018 |
Distinct Roles of Two Histone Methyltransferases in Transmitting H3K36me3-Based Epigenetic Memory Across Generations in
Topics: Animals; Biocatalysis; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Embryonic Development; Epigenesis, Genetic; Female; Histones; Lysine; Male; Methylation; Oocytes; Spermatozoa; Temperature; X Chromosome | 2018 |
Lysines 207 and 325 methylation of WDR5 catalyzed by SETD6 promotes breast cancer cell proliferation and migration.
Topics: Breast Neoplasms; Cell Movement; Cell Proliferation; Female; Histone-Lysine N-Methyltransferase; Humans; Intracellular Signaling Peptides and Proteins; Lysine; MCF-7 Cells; Methylation; Myeloid-Lymphoid Leukemia Protein; Protein Methyltransferases | 2018 |
LNMAT1 promotes lymphatic metastasis of bladder cancer via CCL2 dependent macrophage recruitment.
Topics: Animals; Base Sequence; Cell Line, Tumor; Chemokine CCL2; DNA, Neoplasm; Gene Expression Regulation, Neoplastic; Histones; Humans; Lymphangiogenesis; Lymphatic Metastasis; Lysine; Macrophages; Methylation; Mice; Neoplasm Invasiveness; Prognosis; Promoter Regions, Genetic; Ribonucleoproteins; RNA, Long Noncoding; RNA, Neoplasm; Up-Regulation; Urinary Bladder Neoplasms | 2018 |
Disruption of OCT4 Ubiquitination Increases OCT4 Protein Stability and ASH2L-B-Mediated H3K4 Methylation Promoting Pluripotency Acquisition.
Topics: Amino Acid Sequence; Animals; Cellular Reprogramming; DNA-Binding Proteins; Embryo, Mammalian; Embryonic Stem Cells; Fibroblasts; Histones; Induced Pluripotent Stem Cells; Kruppel-Like Factor 4; Kruppel-Like Transcription Factors; Lysine; Methylation; Mice; Mutation; Nuclear Proteins; Octamer Transcription Factor-3; Protein Binding; Protein Stability; Transcription Factors; Ubiquitin; Ubiquitin-Protein Ligases; Ubiquitination | 2018 |
The H3K9 methyltransferase SETDB1 maintains female identity in Drosophila germ cells.
Topics: Animals; Animals, Genetically Modified; Drosophila melanogaster; Drosophila Proteins; Female; Gametogenesis; Gene Expression Regulation, Developmental; Gene Silencing; Germ Cells; Histone-Lysine N-Methyltransferase; Histones; Homeodomain Proteins; Lysine; Male; Methylation; RNA-Binding Proteins | 2018 |
Differential Methylation of H3K79 Reveals DOT1L Target Genes and Function in the Cerebellum In Vivo.
Topics: Animals; Axon Guidance; Cell Cycle; Cell Differentiation; Cell Movement; Cell Proliferation; Cell Survival; Cerebellum; Cholesterol; Gene Expression Regulation; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Methyltransferases; Mice, Inbred C57BL; Mice, Knockout; Neural Stem Cells; Neurons; Stress, Physiological; Transcriptome | 2019 |
Divergent wiring of repressive and active chromatin interactions between mouse embryonic and trophoblast lineages.
Topics: Animals; Cell Lineage; Chromatin; DNA-Binding Proteins; Embryo, Mammalian; Enhancer Elements, Genetic; Gene Expression Regulation, Developmental; Genome; Histones; Lysine; Methylation; Mice; Mice, Inbred ICR; Mouse Embryonic Stem Cells; Polycomb Repressive Complex 1; Proto-Oncogene Proteins; Trophoblasts | 2018 |
MiR-34 inhibits polycomb repressive complex 2 to modulate chaperone expression and promote healthy brain aging.
Topics: 3' Untranslated Regions; Aging; Animals; Base Sequence; Brain; Drosophila melanogaster; Drosophila Proteins; Gene Expression Profiling; Histones; Lysine; Methylation; MicroRNAs; Models, Biological; Molecular Chaperones; Mutation; Nerve Degeneration; Peptides; Polycomb Repressive Complex 2; Protein Aggregates; Transcriptome | 2018 |
Loss of histone methyltransferase Ezh2 stimulates an osteogenic transcriptional program in chondrocytes but does not affect cartilage development.
Topics: Animals; Cartilage; Cell Differentiation; Chondrocytes; Chondrogenesis; Enhancer of Zeste Homolog 2 Protein; Gene Knockdown Techniques; Histones; Lysine; Methylation; Mice; Osteogenesis; Transcriptome | 2018 |
PWWP2A binds distinct chromatin moieties and interacts with an MTA1-specific core NuRD complex.
Topics: Acetylation; Animals; Chromatin; Chromosomal Proteins, Non-Histone; HEK293 Cells; Histone Deacetylases; Histones; Humans; Lysine; Methylation; Mi-2 Nucleosome Remodeling and Deacetylase Complex; Mice; Nucleosomes; Repressor Proteins; RNA, Small Interfering; Trans-Activators | 2018 |
Methylation Patterns of Lys9 and Lys27 on Histone H3 Correlate with Patient Outcome in Gastric Cancer.
Topics: Adult; Aged; Carcinoma; Epigenesis, Genetic; Female; Histone Code; Histones; Humans; Immunohistochemistry; Kaplan-Meier Estimate; Lysine; Male; Methylation; Middle Aged; Neoplasm Staging; Prognosis; Stomach Neoplasms | 2019 |
KMT2B Is Selectively Required for Neuronal Transdifferentiation, and Its Loss Exposes Dystonia Candidate Genes.
Topics: Animals; Cell Differentiation; Cell Transdifferentiation; Dystonia; Embryo, Mammalian; Epigenesis, Genetic; Fibroblasts; Genetic Association Studies; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Mice, Knockout; Myeloid-Lymphoid Leukemia Protein; Neurons; Transcriptome | 2018 |
Spindlin-1 recognizes methylations of K20 and R23 of histone H4 tail.
Topics: Arginine; Cell Cycle Proteins; Crystallography, X-Ray; HeLa Cells; Histones; Humans; Lysine; Methylation; Microtubule-Associated Proteins; Models, Molecular; Mutation; Phosphoproteins; Protein Binding; Protein Domains | 2018 |
KDM6A and KDM6B play contrasting roles in nuclear transfer embryos revealed by MERVL reporter system.
Topics: Animals; Blastocyst; Cellular Reprogramming; Embryo, Mammalian; Embryonic Development; Endogenous Retroviruses; Female; Fertilization; Gene Knockdown Techniques; Genes, Reporter; Histone Demethylases; Histones; Jumonji Domain-Containing Histone Demethylases; Lysine; Methylation; Mice, Inbred C57BL; Nuclear Transfer Techniques; RNA, Long Noncoding; Transcriptome; Zygote | 2018 |
Topics: Animals; Chromatin; Drosophila melanogaster; Drosophila Proteins; Embryo, Nonmammalian; Enhancer Elements, Genetic; Gene Expression Regulation, Developmental; Histones; Lysine; Methylation; Models, Biological; Polycomb-Group Proteins; Protein Binding | 2018 |
DNMTs and SETDB1 function as co-repressors in MAX-mediated repression of germ cell-related genes in mouse embryonic stem cells.
Topics: Animals; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Biomarkers; Chemical Fractionation; Co-Repressor Proteins; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; Gene Expression Regulation; Germ Cells; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Mice; Mice, Knockout; Mouse Embryonic Stem Cells; Multiprotein Complexes; Polycomb Repressive Complex 1; Protein Binding | 2018 |
Deciphering and engineering chromodomain-methyllysine peptide recognition.
Topics: Chromatin; Chromobox Protein Homolog 5; Chromosomal Proteins, Non-Histone; HeLa Cells; Histones; Humans; Lysine; Methylation; Models, Molecular; Mutation; Peptide Fragments; Protein Array Analysis; Protein Binding; Protein Engineering; Protein Interaction Domains and Motifs; Protein Processing, Post-Translational | 2018 |
Arginine methylation of SIRT7 couples glucose sensing with mitochondria biogenesis.
Topics: Adenylate Kinase; Amino Acid Sequence; Arginine; Glucose; HEK293 Cells; Histones; Humans; Lysine; Methylation; Nuclear Proteins; Organelle Biogenesis; Protein-Arginine N-Methyltransferases; Sirtuins | 2018 |
The chromatin remodeler ZmCHB101 impacts alternative splicing contexts in response to osmotic stress.
Topics: Adaptation, Physiological; Alternative Splicing; Arabidopsis; Chromatin Assembly and Disassembly; Exons; Gene Expression Regulation, Plant; Histones; Lysine; Methylation; Nucleosomes; Osmotic Pressure; Plant Proteins; Plants, Genetically Modified; RNA Polymerase II; Stress, Physiological; Transcription, Genetic; Zea mays | 2019 |
Chromatin Modifiers SET-25 and SET-32 Are Required for Establishment but Not Long-Term Maintenance of Transgenerational Epigenetic Inheritance.
Topics: Animals; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Chromatin; Epigenesis, Genetic; Gene Silencing; Germ Cells; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Inheritance Patterns; Longevity; Lysine; Male; Methylation; Models, Genetic; Mutation; Phenotype; RNA; RNA, Small Interfering; Spermatozoa | 2018 |
ASH1-catalyzed H3K36 methylation drives gene repression and marks H3K27me2/3-competent chromatin.
Topics: Chromatin; Epigenetic Repression; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Neurospora crassa; Protein Processing, Post-Translational | 2018 |
A functional proteomics platform to reveal the sequence determinants of lysine methyltransferase substrate selectivity.
Topics: Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Mutation, Missense; Proteome; Substrate Specificity | 2018 |
MacroH2A1 chromatin specification requires its docking domain and acetylation of H2B lysine 20.
Topics: Acetylation; Amino Acid Sequence; Binding Sites; Cell Line; Chromatin; Gene Expression Regulation; HEK293 Cells; Histones; Humans; Immunoblotting; Lysine; Methylation; Protein Binding; Sequence Homology, Amino Acid | 2018 |
Diabetes induces tri-methylation at lysine 9 of histone 3 at Slc2a4 gene in skeletal muscle: A new target to improve glycemic control.
Topics: Animals; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Disease Models, Animal; Epigenesis, Genetic; Glucose Transporter Type 4; Histones; Humans; Insulin; Lysine; Male; Methylation; Mice; Muscle, Skeletal; Promoter Regions, Genetic; Rats; Resveratrol | 2019 |
Lysine methylation by the mitochondrial methyltransferase FAM173B optimizes the function of mitochondrial ATP synthase.
Topics: Animals; Cell Line; Computational Biology; HeLa Cells; Histone-Lysine N-Methyltransferase; Humans; Lysine; Methylation; Mice; Mitochondria; Mitochondrial Proton-Translocating ATPases | 2019 |
A chromatin integration labelling method enables epigenomic profiling with lower input.
Topics: Animals; Cell Line; Cell Line, Tumor; Chromatin; DNA Probes; Epigenomics; Gene Expression Profiling; Histones; Humans; Lysine; MCF-7 Cells; Methylation; Mice; Myoblasts; Reproducibility of Results; Sequence Analysis, DNA; Single-Cell Analysis | 2019 |
Cation-π Interactions between Methylated Ammonium Groups and Tryptophan in the CHARMM36 Additive Force Field.
Topics: Ammonium Compounds; Cations; Choline; Dimerization; Lysine; Methylation; Proteins; Quantum Theory; Solvents; Thermodynamics; Tryptophan | 2019 |
A nuclear lamina-chromatin-Ran GTPase axis modulates nuclear import and DNA damage signaling.
Topics: Active Transport, Cell Nucleus; Azepines; Chromatin; DNA Damage; Fibroblasts; Histones; Humans; Interphase; Lamin Type A; Lysine; Methylation; Nuclear Lamina; Progeria; Quinazolines; ran GTP-Binding Protein; Signal Transduction | 2019 |
Epigenetic impairments in development of parthenogenetic preimplantation mouse embryos.
Topics: Acetylation; Animals; Arginine; Blastocyst; Chromatin; Chromatin Assembly and Disassembly; Chromobox Protein Homolog 5; Chromosomal Proteins, Non-Histone; Embryonic Development; Epigenesis, Genetic; Female; Gene Expression Regulation, Developmental; Histones; Lysine; Male; Methylation; Mice; Mice, Inbred ICR; Parthenogenesis; Sperm Injections, Intracytoplasmic | 2019 |
Identification of selective and reversible LSD1 inhibitors with anti-metastasis activity by high-throughput docking.
Topics: Cell Line, Tumor; Demethylation; Enzyme Inhibitors; Histone Demethylases; Histones; Humans; Lysine; Methylation; Molecular Docking Simulation; Neoplasm Metastasis; Neoplasms; Structure-Activity Relationship | 2019 |
METTL13 Methylation of eEF1A Increases Translational Output to Promote Tumorigenesis.
Topics: Adult; Aged; Animals; Carcinogenesis; Cell Line; Cell Transformation, Neoplastic; Female; HEK293 Cells; Heterografts; Humans; Lysine; Male; Methylation; Methyltransferases; Mice; Mice, Inbred C57BL; Mice, Knockout; Mice, Transgenic; Pancreatic Neoplasms; Peptide Elongation Factor 1; Protein Biosynthesis; Protein Processing, Post-Translational; Proteomics; Signal Transduction | 2019 |
A Modular Ligation Strategy for Asymmetric Bivalent Nucleosomes Trimethylated at K36 and K27.
Topics: Disulfides; Histones; Humans; Lysine; Methylation; Nucleosomes; Polycomb Repressive Complex 2; Protein Binding | 2019 |
The methyltransferase SETD6 regulates Mitotic progression through PLK1 methylation.
Topics: Cell Cycle; Cell Cycle Proteins; Cell Line, Tumor; Cell Proliferation; Cytokinesis; HeLa Cells; Humans; Lysine; Methylation; Mitosis; Polo-Like Kinase 1; Protein Methyltransferases; Protein Serine-Threonine Kinases; Proteomics; Proto-Oncogene Proteins; Signal Transduction | 2019 |
Epigenetically modulated FOXM1 suppresses dendritic cell maturation in pancreatic cancer and colon cancer.
Topics: Adenocarcinoma; Adenosine; Animals; Bone Marrow Cells; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Colonic Neoplasms; Culture Media, Conditioned; Dendritic Cells; Epigenesis, Genetic; Forkhead Box Protein M1; Gene Expression Regulation, Neoplastic; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Male; Methylation; Mice, Inbred BALB C; Mice, Inbred C57BL; Models, Biological; Pancreatic Neoplasms; Phenylurea Compounds; Signal Transduction; Thiostrepton; Wnt-5a Protein | 2019 |
Inhibition of EHMT1/2 rescues synaptic and cognitive functions for Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Chromosome Deletion; Cognition; Cognition Disorders; Cognitive Dysfunction; Disease Models, Animal; DNA Methylation; Epigenesis, Genetic; Hippocampus; Histocompatibility Antigens; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Memory Disorders; Methylation; Mice; Mice, Transgenic; Prefrontal Cortex; Synapses | 2019 |
TRIM28 down-regulation on methylation imprints in bovine preimplantation embryos.
Topics: Animals; Blastocyst; Cattle; Down-Regulation; Female; Fertilization in Vitro; Gene Expression Regulation, Developmental; Gene Knockdown Techniques; In Vitro Oocyte Maturation Techniques; Lysine; Male; Methylation; Nuclear Transfer Techniques; Oocytes; RNA, Small Interfering; Tripartite Motif-Containing Protein 28 | 2018 |
SETDB1-mediated methylation of Akt promotes its K63-linked ubiquitination and activation leading to tumorigenesis.
Topics: A549 Cells; Animals; Carcinogenesis; Carcinoma, Non-Small-Cell Lung; Female; HEK293 Cells; Histone-Lysine N-Methyltransferase; Humans; Lung Neoplasms; Lysine; Methylation; Mice; Mice, Inbred BALB C; Mice, Knockout; Mice, Nude; NIH 3T3 Cells; Protein Methyltransferases; Proto-Oncogene Proteins c-akt; Transplantation, Heterologous; Ubiquitination | 2019 |
Lysine 27 of replication-independent histone H3.3 is required for Polycomb target gene silencing but not for gene activation.
Topics: Alleles; Animals; Chromatin; CRISPR-Cas Systems; DNA Replication; DNA-Binding Proteins; Drosophila melanogaster; Epigenesis, Genetic; Gene Silencing; Histone Code; Histones; Humans; Lysine; Methylation; Polycomb-Group Proteins; Transcriptional Activation | 2019 |
G9a-dependent histone methylation can be induced in G1 phase of cell cycle.
Topics: Animals; Cell Line; Female; G1 Phase; Geminin; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Mice, Knockout; Mitosis | 2019 |
Histone H3K9 demethylase JMJD1A is a co-activator of erythropoietin expression under hypoxia.
Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Biocatalysis; Erythropoietin; Gene Expression Regulation; Hep G2 Cells; Histones; Humans; Hypoxia; Jumonji Domain-Containing Histone Demethylases; Lysine; Male; Methylation; Mice; Mice, Inbred C57BL; Transcription, Genetic | 2019 |
Gamma radiation induces locus specific changes to histone modification enrichment in zebrafish and Atlantic salmon.
Topics: Animals; Embryonic Development; Gametogenesis; Gamma Rays; Genetic Loci; Histone Code; Histones; Lysine; Methylation; Salmo salar; Zebrafish | 2019 |
Allyl isothiocyanate regulates lysine acetylation and methylation marks in an experimental model of malignant melanoma.
Topics: Acetylation; Animals; Blotting, Western; Cells, Cultured; Disease Models, Animal; Humans; Isothiocyanates; Lysine; Melanoma; Methylation; Mice | 2020 |
Hibernation impacts lysine methylation dynamics in the 13-lined ground squirrel, Ictidomys tridecemlineatus.
Topics: Animals; Hibernation; Histone Methyltransferases; Histones; Liver; Lysine; Methylation; Methyltransferases; Muscle, Skeletal; Sciuridae; Transcription Factors | 2019 |
H3K9me3, H3K36me3, and H4K20me3 Expression Correlates with Patient Outcome in Esophageal Squamous Cell Carcinoma as Epigenetic Markers.
Topics: Adult; Aged; Biomarkers, Tumor; DNA Methylation; Epigenesis, Genetic; Esophageal Neoplasms; Esophageal Squamous Cell Carcinoma; Female; Histones; Humans; Immunohistochemistry; Lysine; Male; Methylation; Middle Aged; Predictive Value of Tests; Prognosis; Protein Processing, Post-Translational; Tissue Array Analysis | 2019 |
An augmentation in histone dimethylation at lysine nine residues elicits vision impairment following traumatic brain injury.
Topics: Animals; Brain Injuries, Traumatic; Disease Models, Animal; Histones; Lysine; Male; Methylation; Mice; Mice, Inbred C57BL; Myelin Sheath; NF-E2-Related Factor 2; Optic Nerve; Oxidative Stress; Retinal Ganglion Cells; Vision Disorders | 2019 |
H4K20me0 recognition by BRCA1-BARD1 directs homologous recombination to sister chromatids.
Topics: Amino Acid Sequence; BRCA1 Protein; Cell Line, Tumor; Chromatids; DNA Breaks, Double-Stranded; DNA Repair; G2 Phase; HCT116 Cells; HeLa Cells; Histones; Homologous Recombination; Humans; Lysine; Methylation; S Phase; Sequence Homology, Amino Acid; Tumor Suppressor Proteins; Ubiquitin-Protein Ligases | 2019 |
Ash1 counteracts Polycomb repression independent of histone H3 lysine 36 methylation.
Topics: Alleles; Animals; Chromatin; DNA-Binding Proteins; Drosophila; Drosophila Proteins; Gene Expression Regulation; Genetic Loci; Histone-Lysine N-Methyltransferase; Histones; Loss of Function Mutation; Lysine; Methylation; Phenotype; Polycomb-Group Proteins; Protein Binding; Protein Interaction Domains and Motifs; Transcription Factors | 2019 |
SUMOylation of G9a regulates its function as an activator of myoblast proliferation.
Topics: Animals; Cell Differentiation; Cell Proliferation; Chlorocebus aethiops; Chromatin; COS Cells; E2F1 Transcription Factor; HEK293 Cells; Histocompatibility Antigens; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Mice; Mice, Transgenic; Muscle Development; Myoblasts, Skeletal; MyoD Protein; p300-CBP Transcription Factors; Protein Processing, Post-Translational; Sumoylation | 2019 |
Histone H3 trimethylation at lysine 36 guides m
Topics: Adenosine; Animals; Cell Differentiation; Cell Line; Embryonic Stem Cells; Histones; Humans; Lysine; Methylation; Methyltransferases; Mice; RNA Polymerase II; RNA, Messenger; Transcription Elongation, Genetic; Transcription, Genetic; Transcriptome | 2019 |
Histone serotonylation is a permissive modification that enhances TFIID binding to H3K4me3.
Topics: Animals; Cell Differentiation; Cell Line; Female; Gene Expression Regulation; Glutamine; GTP-Binding Proteins; Histones; Humans; Lysine; Methylation; Mice; Mice, Inbred C57BL; Protein Binding; Protein Glutamine gamma Glutamyltransferase 2; Protein Processing, Post-Translational; Serotonergic Neurons; Serotonin; Transcription Factor TFIID; Transglutaminases | 2019 |
Hypoxia induces rapid changes to histone methylation and reprograms chromatin.
Topics: Amino Acids, Dicarboxylic; Animals; Cell Hypoxia; Chromatin; Fibroblasts; HeLa Cells; Histones; Humans; Lysine; Methylation; Oxygen; Protein Domains; Retinoblastoma-Binding Protein 2 | 2019 |
Inhibition of Ezh2 In Vitro and the Decline of
Topics: Animals; Cell Differentiation; Cells, Cultured; Dopaminergic Neurons; Enhancer of Zeste Homolog 2 Protein; Epigenesis, Genetic; Histone Deacetylase Inhibitors; Histones; Indazoles; Lysine; Mesencephalon; Methylation; Neural Stem Cells; Nuclear Receptor Subfamily 4, Group A, Member 2; Promoter Regions, Genetic; Pyridones; Rats; Rats, Sprague-Dawley; RNA, Small Interfering; Tyrosine 3-Monooxygenase | 2019 |
Regulation of RNA methylation by modified histones.
Topics: Histones; Lysine; Methylation; RNA | 2019 |
The expanding landscape of 'oncohistone' mutations in human cancers.
Topics: Cell Transformation, Neoplastic; Histones; Humans; Lysine; Methylation; Mutation; Neoplasms; Nucleosomes; Protein Domains; Protein Processing, Post-Translational | 2019 |
Epigenetic regulation of phosphodiesterase 4d in restrictive cardiomyopathy mice with cTnI mutations.
Topics: Acetylation; Animals; Cardiomyopathy, Restrictive; Cell Nucleus; Cyclic Nucleotide Phosphodiesterases, Type 4; Disease Models, Animal; DNA-Binding Proteins; Epigenesis, Genetic; Heart; Histone Deacetylase 1; Histones; Lysine; Methylation; Mice; Muscle Proteins; Mutation; Myocytes, Cardiac; Promoter Regions, Genetic; Transcription Factors; Troponin I | 2020 |
Effect of Histone Lysine Methylation on DNA Lesion Reactivity in Nucleosome Core Particles.
Topics: Antineoplastic Agents; DNA; DNA Damage; Histones; Lysine; Methylation; Nucleosomes | 2019 |
IBM1-dependent H3K9 demethylation enables self-silencing of an exogenous silencer for the non-cell autonomous silencing of an endogenous target gene.
Topics: Arabidopsis Proteins; Gene Silencing; Histones; Jumonji Domain-Containing Histone Demethylases; Lysine; Methylation | 2019 |
Identification, Quantification, and System Analysis of Protein N-ε Lysine Methylation in Anucleate Blood Platelets.
Topics: Blood Platelets; Endoplasmic Reticulum Chaperone BiP; Humans; Lysine; Methylation; Protein Processing, Post-Translational; Proteome; Proteomics; Tandem Mass Spectrometry | 2019 |
Destabilization of chromosome structure by histone H3 lysine 27 methylation.
Topics: Ascomycota; Chromosomes, Fungal; Gene Deletion; Genomic Instability; Heterochromatin; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Repetitive Sequences, Nucleic Acid; Transcriptional Activation | 2019 |
Asymmetric dimethylation and citrullination of proteinic arginine and homoarginine synthesis in human Helicobacter pylori infection.
Topics: Adult; Aged; Aged, 80 and over; Arginine; Citrullination; Citrulline; Female; Gas Chromatography-Mass Spectrometry; Helicobacter Infections; Helicobacter pylori; Homoarginine; Humans; Lysine; Male; Methylation; Middle Aged; Nitric Oxide; Ornithine | 2019 |
Substrate-Differentiated Transition States of SET7/9-Catalyzed Lysine Methylation.
Topics: Catalysis; Histone-Lysine N-Methyltransferase; Histones; Humans; Kinetics; Lysine; Methylation; Protein Binding; Protein Conformation; Protein Processing, Post-Translational; S-Adenosylmethionine; Tumor Suppressor Protein p53 | 2019 |
Fine-tuning AKT kinase activity through direct lysine methylation.
Topics: Animals; Carcinogenesis; Histone-Lysine N-Methyltransferase; Histones; Humans; Jumonji Domain-Containing Histone Demethylases; Lysine; Methylation; Neoplasms; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt | 2019 |
KMT9 monomethylates histone H4 lysine 12 and controls proliferation of prostate cancer cells.
Topics: Cell Line, Tumor; Cell Proliferation; Dimerization; Histones; Humans; Lysine; Male; Methylation; Methyltransferases; Prostatic Neoplasms, Castration-Resistant; Site-Specific DNA-Methyltransferase (Adenine-Specific) | 2019 |
Zfp281 Shapes the Transcriptome of Trophoblast Stem Cells and Is Essential for Placental Development.
Topics: Animals; Base Sequence; Cell Differentiation; Cell Line; Embryonic Stem Cells; Epigenesis, Genetic; Female; Fibroblast Growth Factors; Gene Expression Regulation, Developmental; Genetic Loci; Genetic Testing; Haploidy; Histones; Humans; Lysine; Methylation; Mice, Knockout; Placentation; Pregnancy; Repressor Proteins; Stem Cells; Transcription Factors; Transcription, Genetic; Transcriptome; Trophoblasts | 2019 |
A new chromatographic approach to analyze methylproteome with enhanced lysine methylation identification performance.
Topics: Arginine; Chromatography, Affinity; Chromatography, Ion Exchange; Chromatography, Reverse-Phase; Hydrogen-Ion Concentration; Lysine; Methylation; Proteome | 2019 |
SETD1A Methyltransferase Is Physically and Functionally Linked to the DNA Damage Repair Protein RAD18.
Topics: DNA Damage; DNA Repair; DNA-Binding Proteins; Down-Regulation; HEK293 Cells; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Phenotype; Protein Binding; Protein Interaction Maps; Protein Subunits; Proteomics; RNA, Messenger; Ubiquitin-Protein Ligases | 2019 |
The SNP of rs6854845 suppresses transcription via the DNA looping structure alteration of super-enhancer in colon cells.
Topics: Base Sequence; Cell Line, Tumor; Chromatin; Colon; DNA; Enhancer Elements, Genetic; Epithelial Cells; Gene Expression Regulation, Neoplastic; Histones; Humans; Lysine; Methylation; Multigene Family; Nucleic Acid Conformation; Polymorphism, Single Nucleotide; Transcription, Genetic | 2019 |
γ-Thialysine versus Lysine: An Insight into the Epigenetic Methylation of Histones.
Topics: Cysteine; Histone-Lysine N-Methyltransferase; Histones; Humans; Kinetics; Lysine; Methylation; Models, Molecular; Substrate Specificity | 2019 |
Chromatin Immunoprecipitation Assay Using Micrococcal Nucleases in Mammalian Cells.
Topics: Androgens; Animals; Cell Line, Tumor; Chromatin; Chromatin Immunoprecipitation; DNA; Enhancer Elements, Genetic; Genome, Human; Histones; Humans; Lysine; Mammals; Methylation; Micrococcal Nuclease; Promoter Regions, Genetic; RNA Polymerase II; Sonication | 2019 |
Structural and biochemical characterization of Rv0187, an O-methyltransferase from Mycobacterium tuberculosis.
Topics: Bacterial Proteins; Catalytic Domain; Catechol O-Methyltransferase; Coenzymes; Crystallography, X-Ray; Enzyme Assays; Lysine; Methylation; Models, Molecular; Mutation; Mycobacterium tuberculosis; Recombinant Proteins; S-Adenosylhomocysteine; Strontium; Substrate Specificity | 2019 |
Insights into active intragenic enhancers.
Topics: Enhancer Elements, Genetic; Gene Expression Regulation; HeLa Cells; Histones; Humans; Lysine; Methylation; RNA Stability | 2019 |
Hematopoietic stem and progenitor cell proliferation and differentiation requires the trithorax protein Ash2l.
Topics: Animals; Cell Differentiation; Cell Proliferation; Chromatin; DNA-Binding Proteins; Gene Expression Regulation; Hematopoietic Stem Cells; Histone-Lysine N-Methyltransferase; Histones; Humans; Intracellular Signaling Peptides and Proteins; Lysine; Methylation; Mice; Myeloid-Lymphoid Leukemia Protein; Stem Cells; Transcription Factors | 2019 |
Methylation of Histone H3K79 by Dot1L Requires Multiple Contacts with the Ubiquitinated Nucleosome.
Topics: Histones; Lysine; Methylation; Methyltransferases; Nucleosomes; Ubiquitination | 2019 |
H3K27me3 Signal in the Cis Regulatory Elements Reveals the Differentiation Potential of Progenitors During Drosophila Neuroglial Development.
Topics: Animals; Cell Differentiation; Drosophila melanogaster; Enhancer Elements, Genetic; Epigenesis, Genetic; Histones; Lysine; Methylation; Neural Stem Cells; Neurogenesis; Neuroglia; Nucleosomes; Promoter Regions, Genetic; Regulatory Sequences, Nucleic Acid; Stem Cells; Transcription Initiation Site | 2019 |
Human FAM173A is a mitochondrial lysine-specific methyltransferase that targets adenine nucleotide translocase and affects mitochondrial respiration.
Topics: Amino Acid Sequence; Animals; Chromatography, High Pressure Liquid; HeLa Cells; Histone-Lysine N-Methyltransferase; Humans; Liver; Lysine; Mass Spectrometry; Methylation; Mitochondria; Mitochondrial ADP, ATP Translocases; Mitochondrial Proteins; Peptides; Protein Methyltransferases; Rats; Sequence Alignment | 2019 |
The epigenetic regulator ATF7ip inhibits
Topics: Animals; Cell Differentiation; Colitis; DNA, Intergenic; Epigenesis, Genetic; Histones; Interleukin-2; Lysine; Methylation; Mice, Inbred C57BL; Receptors, Antigen, T-Cell; Repressor Proteins; Th17 Cells | 2019 |
Tip60-dependent acetylation of KDM2B promotes osteosarcoma carcinogenesis.
Topics: Acetylation; Animals; Carcinogenesis; Cell Line, Tumor; F-Box Proteins; Gene Expression Regulation, Neoplastic; Heterografts; Histones; Humans; Jumonji Domain-Containing Histone Demethylases; Lysine; Lysine Acetyltransferase 5; Methylation; Mice; Osteosarcoma; Promoter Regions, Genetic; Protein Processing, Post-Translational | 2019 |
DNMT3B shapes the mCA landscape and regulates mCG for promoter bivalency in human embryonic stem cells.
Topics: Base Sequence; Cell Differentiation; Cell Line; CpG Islands; DNA (Cytosine-5-)-Methyltransferases; DNA Methylation; DNA Methyltransferase 3B; Histones; Human Embryonic Stem Cells; Humans; Lysine; Methylation; Mutation; Promoter Regions, Genetic; Protein Binding | 2019 |
Exercise Modalities Improve Aversive Memory and Survival Rate in Aged Rats: Role of Hippocampal Epigenetic Modifications.
Topics: Acetylation; Aging; Animals; Avoidance Learning; Chromatin; Epigenesis, Genetic; Hippocampus; Histones; Lysine; Male; Memory; Methylation; Physical Conditioning, Animal; Promoter Regions, Genetic; Rats, Wistar; Survival Rate | 2019 |
Rational Adaptation of L3MBTL1 Inhibitors to Create Small-Molecule Cbx7 Antagonists.
Topics: Amino Acid Sequence; Enzyme Inhibitors; Humans; Lysine; Methylation; Models, Molecular; Molecular Structure; Niacinamide; Polycomb Repressive Complex 1; Protein Binding; Protein Conformation; Repressor Proteins; Structure-Activity Relationship; Sulfonamides; Tumor Suppressor Proteins | 2019 |
Dysregulation of histone H3 lysine 27 trimethylation in transforming growth factor-β1-induced gene expression in mesangial cells and diabetic kidney.
Topics: Animals; Cells, Cultured; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Gene Expression Regulation; Histones; Humans; Injections, Intraperitoneal; Lysine; Male; Mesangial Cells; Methylation; Mice; Mice, Inbred C57BL; Rats; Rats, Sprague-Dawley; Streptozocin; Transforming Growth Factor beta1 | 2019 |
EZH2, JMJD3, and UTX epigenetically regulate hepatic plasticity inducing retro-differentiation and proliferation of liver cells.
Topics: Benzazepines; Biomarkers; Cell Differentiation; Cell Line; Cell Proliferation; Cells, Cultured; Enhancer of Zeste Homolog 2 Protein; Epigenesis, Genetic; Gene Expression Profiling; Gene Expression Regulation, Developmental; Hepatocytes; Histone Demethylases; Histones; Humans; Indoles; Jumonji Domain-Containing Histone Demethylases; Liver; Lysine; Methylation; Principal Component Analysis; Pyridones; Pyrimidines | 2019 |
Methylation of H3K27 and H3K4 in key gene promoter regions of thymus in RA mice is involved in the abnormal development and differentiation of iNKT cells.
Topics: Animals; Arthritis, Experimental; Arthritis, Rheumatoid; Cell Differentiation; Epigenesis, Genetic; Gene Expression Regulation; Histone Demethylases; Lysine; Methylation; Mice, Inbred DBA; Natural Killer T-Cells; Promoter Regions, Genetic; Promyelocytic Leukemia Zinc Finger Protein; Spleen; T-Box Domain Proteins; Thymus Gland | 2019 |
p300 Acetylates JHDM1A to inhibit osteosarcoma carcinogenesis.
Topics: Acetylation; Animals; Apoptosis Regulatory Proteins; Carcinogenesis; Cyclin-Dependent Kinase Inhibitor p21; E1A-Associated p300 Protein; F-Box Proteins; Histones; Humans; Jumonji Domain-Containing Histone Demethylases; Lysine; Methylation; Mice; Nucleosomes; Osteosarcoma; Proto-Oncogene Proteins; Transcription, Genetic | 2019 |
Substrate docking-mediated specific and efficient lysine methylation by the SET domain-containing histone methyltransferase SETD7.
Topics: Biocatalysis; Catalytic Domain; Histone-Lysine N-Methyltransferase; Humans; Lysine; Methylation; Substrate Specificity | 2019 |
Vitamin C-dependent lysine demethylase 6 (KDM6)-mediated demethylation promotes a chromatin state that supports the endothelial-to-hematopoietic transition.
Topics: Animals; Animals, Genetically Modified; Ascorbic Acid; Cell Differentiation; Chromatin; Demethylation; Endothelial Cells; Hematopoietic Stem Cells; Histone Demethylases; Histones; Humans; Jumonji Domain-Containing Histone Demethylases; Lysine; Methylation; Pluripotent Stem Cells; Zebrafish | 2019 |
The histone methyltransferase Setd2 is indispensable for V(D)J recombination.
Topics: Amino Acid Motifs; Animals; B-Lymphocytes; Cell Differentiation; Child, Preschool; Epigenesis, Genetic; Histone-Lysine N-Methyltransferase; Histones; Humans; Infant; Lysine; Male; Methylation; Mice; Mice, Inbred C57BL; Mice, Knockout; Mutation; Primary Immunodeficiency Diseases; Receptors, Antigen, T-Cell, alpha-beta; T-Lymphocytes; V(D)J Recombination | 2019 |
The novel methyltransferase SETD4 regulates TLR agonist-induced expression of cytokines through methylation of lysine 4 at histone 3 in macrophages.
Topics: Animals; Cell Line; Chromosomal Proteins, Non-Histone; Cytokines; Histones; Inflammation; Lysine; Macrophages; Methylation; Methyltransferases; Mice; Mice, Inbred C57BL; Mice, Knockout; NF-kappa B; Phosphorylation; Promoter Regions, Genetic; RAW 264.7 Cells; Signal Transduction; Toll-Like Receptors | 2019 |
The SETD6 Methyltransferase Plays an Essential Role in Hippocampus-Dependent Memory Formation.
Topics: Animals; Hippocampus; Histone-Lysine N-Methyltransferase; Lysine; Memory; Methylation; Rats | 2020 |
Structural basis for the target specificity of actin histidine methyltransferase SETD3.
Topics: Actins; Catalytic Domain; Crystallography, X-Ray; Histidine; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Lysine; Methylation; Recombinant Proteins; Substrate Specificity | 2019 |
Identification of lysine methylation in the core GTPase domain by GoMADScan.
Topics: Amino Acid Sequence; Data Mining; GTP Phosphohydrolases; Lysine; Methylation; Molecular Dynamics Simulation; Protein Domains; Protein Processing, Post-Translational | 2019 |
The MLL1 trimeric catalytic complex is a dynamic conformational ensemble stabilized by multiple weak interactions.
Topics: Catalysis; DNA-Binding Proteins; Epigenesis, Genetic; Histone-Lysine N-Methyltransferase; Histones; Humans; Intracellular Signaling Peptides and Proteins; Lysine; Methylation; Models, Molecular; Multiprotein Complexes; Myeloid-Lymphoid Leukemia Protein; PR-SET Domains; Protein Conformation; Protein Interaction Maps; WD40 Repeats | 2019 |
Quantitative analysis of post-translational modifications of histone H3 variants during the cell cycle.
Topics: Acetylation; Amino Acid Sequence; Cell Cycle; Cell Line, Tumor; Chromatography, Liquid; Histones; Humans; Lysine; Mass Spectrometry; Methylation; Protein Isoforms; Protein Processing, Post-Translational | 2019 |
H3K27me3-mediated silencing of structural genes is required for zebrafish heart regeneration.
Topics: Animals; Cell Proliferation; Cytokinesis; Cytoskeleton; Gene Expression Regulation, Developmental; Gene Silencing; Heart; Histones; Lysine; Methylation; Myocytes, Cardiac; Regeneration; Sarcomeres; Zebrafish | 2019 |
LSD1 Inhibition Promotes Epithelial Differentiation through Derepression of Fate-Determining Transcription Factors.
Topics: 3T3 Cells; Adult; Animals; Binding Sites; Carcinoma, Squamous Cell; Cell Differentiation; Cell Line, Tumor; Cell Lineage; Epidermis; Epithelial Cells; Gene Expression Regulation; Genome, Human; Histone Demethylases; Histones; Humans; Lysine; Methylation; Mice; Protein Binding; Snail Family Transcription Factors; Transcription Factors; Transcription, Genetic | 2019 |
Genome-wide identification of histone methylation (H3K9
Topics: Acetylation; Cell Respiration; Epigenomics; Genome, Plant; Genomics; Histones; Lysine; Methylation; Panicum; Photosynthesis; Transcription Factors | 2019 |
H3K4 dimethylation at FosB promoter in the striatum of chronic stressed rats promotes morphine-induced conditioned place preference.
Topics: Animals; Chronic Disease; Conditioning, Classical; Gene Expression Regulation; Histones; Lysine; Male; Methylation; Models, Biological; Morphine; Neostriatum; Promoter Regions, Genetic; Proto-Oncogene Proteins c-fos; Rats, Sprague-Dawley; Receptors, Glucocorticoid; Stress, Psychological; Transcription, Genetic | 2019 |
Quantification of Tau Protein Lysine Methylation in Aging and Alzheimer's Disease.
Topics: Aged; Aged, 80 and over; Aging; Alzheimer Disease; Cells, Cultured; Chromatography, High Pressure Liquid; Female; Humans; Lysine; Male; Metabolomics; Methylation; Middle Aged; Phosphorylation; Protein Processing, Post-Translational; Proteomics; Tandem Mass Spectrometry; tau Proteins | 2019 |
The role of Xist-mediated Polycomb recruitment in the initiation of X-chromosome inactivation.
Topics: Animals; Female; Histones; Lysine; Methylation; Mice; Models, Genetic; Mutation; Polycomb-Group Proteins; Protein Interaction Maps; Repetitive Sequences, Nucleic Acid; RNA, Long Noncoding; Transcription, Genetic; X Chromosome; X Chromosome Inactivation | 2019 |
H3K14 ubiquitylation promotes H3K9 methylation for heterochromatin assembly.
Topics: Amino Acid Sequence; Heterochromatin; Histones; Lysine; Methylation; Methyltransferases; Mutation; Schizosaccharomyces; Schizosaccharomyces pombe Proteins; Ubiquitination | 2019 |
Maintenance of spatial gene expression by Polycomb-mediated repression after formation of a vertebrate body plan.
Topics: Animals; Body Patterning; Embryo, Nonmammalian; Epigenesis, Genetic; Gene Expression Regulation, Developmental; Histones; Lysine; Methylation; Mutation; Polycomb-Group Proteins; Proteome; Repressor Proteins; RNA, Messenger; Transcription Factors; Transcriptome; Vertebrates; Zebrafish; Zygote | 2019 |
Regulation of histone methylation by automethylation of PRC2.
Topics: Enhancer of Zeste Homolog 2 Protein; Enzyme Activation; Gene Expression Regulation; Histones; Humans; Lysine; Methylation; Polycomb Repressive Complex 2; Protein Processing, Post-Translational; Recombinant Proteins | 2019 |
Automethylation of PRC2 promotes H3K27 methylation and is impaired in H3K27M pediatric glioma.
Topics: Child; Enzyme Activation; Gene Silencing; Glioma; Histones; Humans; Lysine; Methylation; Polycomb Repressive Complex 2; Protein Subunits | 2019 |
Engineering Methyllysine Writers and Readers for Allele-Specific Regulation of Protein-Protein Interactions.
Topics: Amino Acid Sequence; Binding Sites; Humans; Lysine; Methylation; Methyltransferases; Models, Molecular; Protein Binding; Protein Conformation; Protein Engineering; Protein Interaction Domains and Motifs; Protein Processing, Post-Translational | 2019 |
Rotamer Jumps, Proton Exchange, and Amine Inversion Dynamics of Dimethylated Lysine Residues in Proteins Resolved by pH-Dependent
Topics: Amines; Carbon-13 Magnetic Resonance Spectroscopy; Hydrogen-Ion Concentration; Lysine; Methylation; Proteins; Proton Magnetic Resonance Spectroscopy; Protons; Solvents | 2019 |
Reduction of Global H3K27me
Topics: Adult; Animals; Breast Neoplasms; Cell Line, Tumor; Drug Resistance, Neoplasm; Enhancer of Zeste Homolog 2 Protein; Female; Histones; Humans; Interferon Type I; Lysine; Methylation; Mice; Models, Biological; Molecular Targeted Therapy; Polycomb Repressive Complex 2; Receptor, ErbB-2; Retroelements; Trastuzumab; Up-Regulation | 2019 |
Quantitative analysis of global protein lysine methylation by mass spectrometry.
Topics: Animals; Chromatography, Liquid; Humans; Lysine; Methylation; Protein Processing, Post-Translational; Proteins; Tandem Mass Spectrometry | 2019 |
Dephosphorylation of p53 Ser 392 Enhances Trimethylation of Histone H3 Lys 9 via SUV39h1 Stabilization in CK2 Downregulation-Mediated Senescence.
Topics: Casein Kinase II; Cell Line, Tumor; Cellular Senescence; Cyclin-Dependent Kinase Inhibitor p21; Down-Regulation; HCT116 Cells; Heterochromatin; Histones; Humans; Lysine; MCF-7 Cells; Methylation; Methyltransferases; Phosphorylation; Protein Stability; Repressor Proteins; RNA Interference; Serine; Signal Transduction; Tumor Suppressor Protein p53 | 2019 |
Inhibition of Polycomb Repressive Complex 2 activity reduces trimethylation of H3K27 and affects development in Arabidopsis seedlings.
Topics: Arabidopsis; Arabidopsis Proteins; Enhancer of Zeste Homolog 2 Protein; Enzyme Inhibitors; Gene Expression Regulation, Developmental; Gene Expression Regulation, Plant; Histones; Lysine; Methylation; Polycomb Repressive Complex 2; Repressor Proteins; Rutin; Seedlings; Seeds | 2019 |
Engineered Reader Proteins for Enhanced Detection of Methylated Lysine on Histones.
Topics: Amino Acid Sequence; Animals; Binding Sites; Chromatin; Chromobox Protein Homolog 5; Cloning, Molecular; Drosophila melanogaster; Epigenesis, Genetic; Gene Expression Regulation; Histones; Humans; Lysine; Methylation; Models, Molecular; Mutation; Nucleosomes; Protein Binding; Protein Conformation; Protein Processing, Post-Translational; Recombinant Proteins; Substrate Specificity | 2020 |
CRISPR/Transposon gene integration (CRITGI) can manage gene expression in a retrotransposon-dependent manner.
Topics: Binding Sites; Chromatin; CRISPR-Cas Systems; Gene Expression Regulation, Fungal; Genes, Fungal; Histones; Lysine; Methylation; Models, Genetic; Mutagenesis, Insertional; Promoter Regions, Genetic; Retroelements; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Transcription, Genetic; Transcriptional Activation | 2019 |
Histone Methylations Define Neural Stem/Progenitor Cell Subtypes in the Mouse Subventricular Zone.
Topics: Animals; Doublecortin Protein; Epigenesis, Genetic; Histones; Lateral Ventricles; Lysine; Methylation; Mice, Inbred C57BL; Neural Stem Cells; Neurogenesis; Protein Processing, Post-Translational; Regeneration; Stem Cells | 2020 |
Inducible histone K-to-M mutations are dynamic tools to probe the physiological role of site-specific histone methylation in vitro and in vivo.
Topics: Animals; Bone Marrow Transplantation; Cell Lineage; Disease Models, Animal; Doxycycline; Epigenesis, Genetic; Erythroid Cells; Female; Granulocytes; Histones; Leukemia, T-Cell; Lysine; Male; Methionine; Methylation; Mice; Mice, Transgenic; Mouse Embryonic Stem Cells; Mutation; Signal Transduction; Survival Analysis; T-Lymphocytes; Teratoma | 2019 |
Function of the MYND Domain and C-Terminal Region in Regulating the Subcellular Localization and Catalytic Activity of the SMYD Family Lysine Methyltransferase Set5.
Topics: Catalytic Domain; Chromatin; Histones; Lysine; Methylation; Methyltransferases; MYND Domains; Phosphorylation; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins | 2020 |
Regulation of EZH2 by SMYD2-Mediated Lysine Methylation Is Implicated in Tumorigenesis.
Topics: Breast Neoplasms; Carcinogenesis; Cell Line, Tumor; Cell Proliferation; Chromatin; Chromatin Immunoprecipitation; Databases, Genetic; Disease Progression; Enhancer of Zeste Homolog 2 Protein; Female; Gene Expression Regulation, Neoplastic; Histone Demethylases; Histone-Lysine N-Methyltransferase; Humans; Lysine; Methylation; Polycomb Repressive Complex 2; Protein Processing, Post-Translational | 2019 |
Protein Methylation and Translation: Role of Lysine Modification on the Function of Yeast Elongation Factor 1A.
Topics: Amino Acid Motifs; Lysine; Methylation; Methyltransferases; Peptide Elongation Factor 1; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins | 2019 |
TCF19 Promotes Cell Proliferation through Binding to the Histone H3K4me3 Mark.
Topics: Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Proliferation; DNA-Binding Proteins; Hep G2 Cells; Histone Code; Histones; Humans; Liver Neoplasms; Lysine; Methylation; Models, Molecular; PHD Zinc Fingers; Protein Binding; Transcription Factors | 2020 |
SET7/9 interacts and methylates the ribosomal protein, eL42 and regulates protein synthesis.
Topics: Amino Acid Sequence; HEK293 Cells; Histone-Lysine N-Methyltransferase; Humans; Lysine; Methylation; Protein Biosynthesis; Protein Domains; Protein Interaction Domains and Motifs; Protein Subunits; Ribosomal Proteins; RNA Interference; RNA, Small Interfering; Two-Hybrid System Techniques | 2020 |
Protein lysine methylation contributes to modulating the response of sensitive and tolerant Arabidopsis species to cadmium stress.
Topics: Adaptation, Physiological; Amino Acid Sequence; Arabidopsis; Arabidopsis Proteins; Cadmium; Gene Expression Regulation, Plant; Lysine; Methylation; Methyltransferases; Mutation; Plant Roots; Stress, Physiological | 2020 |
PRMT1-mediated methylation of the microprocessor-associated proteins regulates microRNA biogenesis.
Topics: Animals; Arginine; Cell Nucleus; Epigenesis, Genetic; HEK293 Cells; HeLa Cells; Humans; Isotope Labeling; Lysine; Methylation; MicroRNAs; Nuclear Factor 90 Proteins; Protein Binding; Protein-Arginine N-Methyltransferases; Repressor Proteins; RNA, Small Interfering | 2020 |
The MADS-box transcription factor PHERES1 controls imprinting in the endosperm by binding to domesticated transposons.
Topics: Amino Acid Motifs; Arabidopsis; Arabidopsis Proteins; Base Sequence; Crosses, Genetic; DNA Transposable Elements; Domestication; Endosperm; Epigenesis, Genetic; Gene Expression Regulation, Plant; Genes, Plant; Genomic Imprinting; Histones; Lysine; MADS Domain Proteins; Methylation; Polyploidy; Promoter Regions, Genetic; Protein Binding; Seeds | 2019 |
TSPAN8 promotes colorectal cancer cell growth and migration in LSD1-dependent manner.
Topics: Cell Line, Tumor; Cell Movement; Cell Proliferation; Colorectal Neoplasms; Epithelial-Mesenchymal Transition; Gene Expression Regulation, Neoplastic; Histone Demethylases; Histones; Humans; Lysine; Methylation; Promoter Regions, Genetic; Tetraspanins | 2020 |
Cryo-EM structure of the human MLL1 core complex bound to the nucleosome.
Topics: Animals; Cell Nucleus; Cryoelectron Microscopy; DNA-Binding Proteins; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Mutation; Myeloid-Lymphoid Leukemia Protein; Nuclear Proteins; Nucleosomes; Protein Binding; Transcription Factors; Xenopus laevis | 2019 |
Protein methylome analysis in Arabidopsis reveals regulation in RNA-related processes.
Topics: Arabidopsis; Epigenome; Lysine; Methylation; Protein Processing, Post-Translational; RNA | 2020 |
Repressive H3K9me2 protects lifespan against the transgenerational burden of COMPASS activity in
Topics: Animals; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Heterochromatin; Histone-Lysine N-Methyltransferase; Histones; Inheritance Patterns; Jumonji Domain-Containing Histone Demethylases; Longevity; Lysine; Methylation; Mutation | 2019 |
Defining decreased protein succinylation of failing human cardiac myofibrils in ischemic cardiomyopathy.
Topics: Acylation; Cardiomyopathies; Heart Failure; Humans; Lysine; Methylation; Middle Aged; Mitochondrial Proteins; Myocardial Ischemia; Myocardium; Myofibrils; Proteomics; Reproducibility of Results; Succinic Acid; Tissue Donors | 2020 |
Global characterization of proteome and lysine methylome features in EZH2 wild-type and mutant lymphoma cell lines.
Topics: Cell Line; Enhancer of Zeste Homolog 2 Protein; Epigenome; Humans; Lymphoma; Lysine; Methylation; Proteome | 2020 |
Methylation of PLK1 by SET7/9 ensures accurate kinetochore-microtubule dynamics.
Topics: Cell Cycle Proteins; Chromosomes, Human; G2 Phase; HEK293 Cells; HeLa Cells; Histone-Lysine N-Methyltransferase; Homeostasis; Humans; Kinetochores; Lysine; Methylation; Microtubules; Mitosis; Polo-Like Kinase 1; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Substrate Specificity | 2020 |
H2A.Z facilitates licensing and activation of early replication origins.
Topics: DNA; DNA Replication; DNA Replication Timing; Epigenesis, Genetic; HeLa Cells; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Nucleosomes; Origin Recognition Complex; Replication Origin | 2020 |
Histone H3K9 methylation is involved in temporomandibular joint osteoarthritis.
Topics: Aging; Animals; Apoptosis; Cell Proliferation; Female; Histones; Lysine; Methylation; Mice; Mice, Inbred C57BL; Osteoarthritis; Temporomandibular Joint | 2020 |
A comprehensive epigenomic analysis of phenotypically distinguishable, genetically identical female and male Daphnia pulex.
Topics: Animals; Daphnia; DNA Methylation; Epigenesis, Genetic; Epigenomics; Female; Gene Expression; Histones; Lysine; Male; Methylation; Phenotype; Promoter Regions, Genetic; Sex Factors | 2020 |
Epigenetic priming by Dot1l in lymphatic endothelial progenitors ensures normal lymphatic development and function.
Topics: Animals; Endothelial Cells; Epigenesis, Genetic; Gene Expression Regulation; Histone-Lysine N-Methyltransferase; Histones; Lymphatic Vessels; Lysine; Methylation; Mice; Receptor, TIE-2; Transcription, Genetic | 2020 |
A crucial RNA-binding lysine residue in the Nab3 RRM domain undergoes SET1 and SET3-responsive methylation.
Topics: Histone Deacetylases; Histone-Lysine N-Methyltransferase; Lysine; Methylation; Nuclear Proteins; Protein Binding; RNA; RNA Recognition Motif; RNA-Binding Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Structure-Activity Relationship | 2020 |
SIRT6 coordinates with CHD4 to promote chromatin relaxation and DNA repair.
Topics: Cell Line, Tumor; Cell Survival; Chromatin; Chromobox Protein Homolog 5; Chromosomal Proteins, Non-Histone; DNA Breaks, Double-Stranded; DNA Repair; HEK293 Cells; Histones; Humans; Lysine; Methylation; Mi-2 Nucleosome Remodeling and Deacetylase Complex; Models, Biological; Protein Binding; Protein Domains; Sirtuins | 2020 |
Histone methyltransferase G9a diminishes expression of cannabinoid CB
Topics: Analgesics; Animals; Cells, Cultured; Ganglia, Spinal; Gene Deletion; Gene Silencing; Glutamates; Histone-Lysine N-Methyltransferase; Histones; Lysine; Male; Methylation; Mice, Inbred C57BL; Nerve Tissue; Neuralgia; Promoter Regions, Genetic; Rats, Sprague-Dawley; Receptor, Cannabinoid, CB1; Receptor, Cannabinoid, CB2; Sensory Receptor Cells; Spinal Cord | 2020 |
miR24-2 accelerates progression of liver cancer cells by activating Pim1 through tri-methylation of Histone H3 on the ninth lysine.
Topics: Animals; Base Sequence; Cell Line, Tumor; Cell Proliferation; Disease Progression; Gene Expression Regulation, Neoplastic; Histones; Humans; Jumonji Domain-Containing Histone Demethylases; Liver Neoplasms; Lysine; Male; Methylation; Methyltransferases; Mice, Inbred BALB C; Mice, Nude; MicroRNAs; Models, Biological; Oncogenes; Proto-Oncogene Proteins c-pim-1 | 2020 |
Methylation of geometrically constrained lysine analogues by histone lysine methyltransferases.
Topics: Alkenes; Alkynes; Biocatalysis; Histone-Lysine N-Methyltransferase; Humans; Lysine; Methylation; Molecular Conformation | 2020 |
Monitoring the crosstalk between methylation and phosphorylation on histone peptides with host-assisted capillary electrophoresis.
Topics: Amino Acid Sequence; Electrophoresis, Capillary; Histones; Lysine; Methylation; Peptides; Phosphorylation; Protein Processing, Post-Translational | 2020 |
Histone demethylase KDM4D cooperates with NFIB and MLL1 complex to regulate adipogenic differentiation of C3H10T1/2 mesenchymal stem cells.
Topics: Adipogenesis; Animals; CCAAT-Enhancer-Binding Protein-alpha; Cell Differentiation; Cell Line; Histone-Lysine N-Methyltransferase; Histones; Jumonji Domain-Containing Histone Demethylases; Lysine; Mesenchymal Stem Cells; Methylation; Mice; Models, Biological; Myeloid-Lymphoid Leukemia Protein; NFI Transcription Factors; PPAR gamma; Promoter Regions, Genetic; Protein Binding | 2020 |
A novel EZH2 inhibitor induces synthetic lethality and apoptosis in PBRM1-deficient cancer cells.
Topics: Apoptosis; Cell Line, Tumor; Cell Proliferation; DNA-Binding Proteins; Drug Screening Assays, Antitumor; Enhancer of Zeste Homolog 2 Protein; Histones; Humans; Indoles; Lysine; Methylation; Molecular Docking Simulation; Molecular Dynamics Simulation; Neoplasms; Prognosis; Pyridones; Reproducibility of Results; Synthetic Lethal Mutations; Transcription Factors | 2020 |
Two conserved epigenetic regulators prevent healthy ageing.
Topics: Aging; Animals; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Cognition; Cognitive Dysfunction; Epigenesis, Genetic; Healthy Aging; Histone-Lysine N-Methyltransferase; Histones; Humans; Longevity; Lysine; Male; Memory; Methylation; Mice; Mitochondria; Neurons; Proteins; RNA Interference; Spatial Learning; Transcription Factors, General | 2020 |
Isoform-Specific Lysine Methylation of RORα2 by SETD7 Is Required for Association of the TIP60 Coactivator Complex in Prostate Cancer Progression.
Topics: Animals; Cell Proliferation; Chromatin Immunoprecipitation; Chromatography, Liquid; Disease Progression; Gene Expression Regulation, Neoplastic; Histone-Lysine N-Methyltransferase; Humans; Lysine; Lysine Acetyltransferase 5; Male; Methylation; Mice; Mice, Nude; Nuclear Receptor Subfamily 1, Group F, Member 1; Oncogenes; PC-3 Cells; Prostatic Neoplasms; Protein Binding; Protein Domains; Protein Isoforms; Tandem Mass Spectrometry; Trans-Activators | 2020 |
Natural T Cell Epitope Containing Methyl Lysines on Mycobacterial Heparin-Binding Hemagglutinin.
Topics: Antigens, Bacterial; Epitopes, T-Lymphocyte; Humans; Interferon-gamma; Lectins; Lysine; Methylation; Mycobacterium smegmatis; Mycobacterium tuberculosis; Protein Processing, Post-Translational; T-Lymphocytes | 2020 |
Computational approaches to studying methylated H4K20 recognition by DNA repair factor 53BP1.
Topics: Computational Biology; Histones; Lysine; Methylation; Models, Molecular; Protein Binding; Protein Stability; Protein Structure, Quaternary; Tumor Suppressor p53-Binding Protein 1 | 2020 |
Coordinated demethylation of H3K9 and H3K27 is required for rapid inflammatory responses of endothelial cells.
Topics: Animals; Cell Adhesion; Endothelial Cells; Gene Expression Regulation; Gene Regulatory Networks; Histone Demethylases; Histones; Human Umbilical Vein Endothelial Cells; Humans; Jumonji Domain-Containing Histone Demethylases; Lysine; Male; Methylation; Mice; MicroRNAs; Signal Transduction; Tumor Necrosis Factor-alpha | 2020 |
A methylated lysine is a switch point for conformational communication in the chaperone Hsp90.
Topics: Adenosine Triphosphate; Amino Acid Sequence; Conserved Sequence; HSP90 Heat-Shock Proteins; Lysine; Methylation; Molecular Dynamics Simulation; Mutation; Nucleotides; Saccharomyces cerevisiae; Structure-Activity Relationship | 2020 |
Trimethylation of histone H3K76 by Dot1B enhances cell cycle progression after mitosis in Trypanosoma cruzi.
Topics: Cell Cycle; Chagas Disease; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Mitosis; Nuclear Proteins; Phosphorylation; Trypanosoma cruzi | 2020 |
The Dm-Myb Oncoprotein Contributes to Insulator Function and Stabilizes Repressive H3K27me3 PcG Domains.
Topics: Animals; Cell Cycle Proteins; Drosophila melanogaster; Drosophila Proteins; Histones; Insulator Elements; Lysine; Methylation; Oncogene Proteins; Polycomb-Group Proteins; Protein Binding; Protein Domains; Protein Stability; Proto-Oncogene Proteins c-myb; RNA Polymerase II; Transcription Initiation Site | 2020 |
KMT Set7/9 is a new regulator of Sam68 STAR-protein.
Topics: Adaptor Proteins, Signal Transducing; Apoptosis; Cell Cycle; Cell Cycle Proteins; Cell Line, Tumor; Colonic Neoplasms; Computational Biology; Cytoplasm; DNA-Binding Proteins; Gene Expression Regulation, Neoplastic; Gene Knockout Techniques; Histone-Lysine N-Methyltransferase; Humans; Lysine; Mass Spectrometry; Methylation; Protein Binding; Protein Domains; Protein Interaction Maps; RNA-Binding Proteins | 2020 |
Identification of a PRC2 Accessory Subunit Required for Subtelomeric H3K27 Methylation in Neurospora crassa.
Topics: Gene Deletion; Histones; Lysine; Methylation; Neurospora crassa; Polycomb Repressive Complex 2; Protein Subunits; Protozoan Proteins | 2020 |
Highly Sensitive and Multiplexed In-Situ Protein Profiling with Cleavable Fluorescent Streptavidin.
Topics: Antibodies; Biotin; Fluorescence; Fluorescent Dyes; Formaldehyde; HeLa Cells; Histones; Humans; Ki-67 Antigen; Lysine; Methylation; Paraffin Embedding; Proteins; Streptavidin; Tissue Fixation | 2020 |
H3K4me3 Is a Potential Mediator for Antiproliferative Effects of Calcitriol (1α,25(OH)2D3) in Ovarian Cancer Biology.
Topics: Adult; Aged; Aged, 80 and over; Calcitriol; Cell Line, Tumor; Cell Proliferation; Epigenesis, Genetic; Female; Histones; Humans; Kaplan-Meier Estimate; Lysine; Methylation; Middle Aged; Multivariate Analysis; Ovarian Neoplasms; Proportional Hazards Models; Receptors, Calcitriol; Survival Analysis | 2020 |
Two-Level Protein Methylation Prediction using structure model-based features.
Topics: Amino Acid Sequence; Animals; Arginine; Databases, Protein; Humans; Lysine; Methylation; Models, Biological; Models, Molecular; Protein Processing, Post-Translational; Proteins; Support Vector Machine | 2020 |
Comprehensive histochemical profiles of histone modification in male germline cells during meiosis and spermiogenesis: Comparison of young and aged testes in mice.
Topics: Acetylation; Animals; Epigenesis, Genetic; Epigenomics; Gene Expression; Histone Code; Histones; Humans; Lysine; Male; Meiosis; Methylation; Mice; Protein Processing, Post-Translational; Sex Chromosomes; Spermatids; Spermatocytes; Spermatogenesis; Testis | 2020 |
Chromatin architecture reorganization in murine somatic cell nuclear transfer embryos.
Topics: Animals; Cellular Reprogramming; Chromatin; Embryo, Mammalian; Embryonic Development; Enhancer Elements, Genetic; Gene Expression Regulation, Developmental; Genome; Histones; Lysine; Metaphase; Methylation; Mice; Nuclear Transfer Techniques; Promoter Regions, Genetic; Zygote | 2020 |
EZH2-mediated H3K27me3 inhibits ACE2 expression.
Topics: Angiotensin-Converting Enzyme 2; Animals; Betacoronavirus; Coronavirus Infections; COVID-19; Embryonic Stem Cells; Enhancer of Zeste Homolog 2 Protein; Epigenesis, Genetic; Gene Expression Regulation; Gene Knockout Techniques; Histone Code; Histones; Humans; Lysine; Methylation; Mice; Organ Specificity; Pandemics; Peptidyl-Dipeptidase A; Pneumonia, Viral; Promoter Regions, Genetic; SARS-CoV-2; Transcription, Genetic; Up-Regulation | 2020 |
X-Linked RNA-Binding Motif Protein Modulates HIV-1 Infection of CD4
Topics: CD4-Positive T-Lymphocytes; Gene Expression Regulation, Viral; Gene Knockdown Techniques; Heterogeneous-Nuclear Ribonucleoproteins; Histones; HIV Infections; HIV Long Terminal Repeat; HIV-1; Humans; Lysine; Methylation; Protein Binding; Proviruses; Transcription, Genetic | 2020 |
Comparison of Molecular Recognition of Trimethyllysine and Trimethylthialysine by Epigenetic Reader Proteins.
Topics: Binding Sites; Cysteine; Epigenesis, Genetic; Histones; Humans; Lysine; Methylation; Models, Molecular; Molecular Conformation; Protein Binding; Solid-Phase Synthesis Techniques; Structure-Activity Relationship; Thermodynamics | 2020 |
The Set1 N-terminal domain and Swd2 interact with RNA polymerase II CTD to recruit COMPASS.
Topics: Chromatin; Chromatin Immunoprecipitation Sequencing; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Point Mutation; Protein Binding; Protein Domains; Protein Processing, Post-Translational; RNA Polymerase II; RNA-Binding Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Ubiquitination | 2020 |
Radiation Induces Autophagy
Topics: Adaptor Proteins, Signal Transducing; Autophagy; Biomarkers, Tumor; Carcinoma, Non-Small-Cell Lung; Cell Line, Tumor; Epigenesis, Genetic; Histones; Humans; Lung Neoplasms; Lysine; Methylation; Microtubule-Associated Proteins; RNA, Small Interfering | 2020 |
LncRNA CANT1 suppresses retinoblastoma progression by repellinghistone methyltransferase in PI3Kγ promoter.
Topics: Carcinogenesis; Cell Line; Class Ib Phosphatidylinositol 3-Kinase; Disease Progression; Down-Regulation; Gene Expression Regulation, Neoplastic; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Promoter Regions, Genetic; Protein Binding; Proto-Oncogene Proteins c-akt; Retinoblastoma; RNA, Long Noncoding; Signal Transduction; Transcription, Genetic | 2020 |
Uncoupling histone H3K4 trimethylation from developmental gene expression via an equilibrium of COMPASS, Polycomb and DNA methylation.
Topics: Animals; Chromosomal Proteins, Non-Histone; Clustered Regularly Interspaced Short Palindromic Repeats; DNA Methylation; Gene Expression Regulation, Developmental; Gene Knockdown Techniques; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Mice; Mice, Transgenic; Mouse Embryonic Stem Cells; Myeloid-Lymphoid Leukemia Protein; Polycomb-Group Proteins; Promoter Regions, Genetic; Trans-Activators | 2020 |
MMTR/Dmap1 Sets the Stage for Early Lineage Commitment of Embryonic Stem Cells by Crosstalk with PcG Proteins.
Topics: Animals; Cell Differentiation; Cell Lineage; Chromatin Assembly and Disassembly; DNA Helicases; DNA-Binding Proteins; HEK293 Cells; Histones; Humans; Lysine; Lysine Acetyltransferase 5; Methylation; Mice; Mice, SCID; Models, Biological; Mouse Embryonic Stem Cells; Polycomb Repressive Complex 2; Polycomb-Group Proteins; Promoter Regions, Genetic; Protein Binding; Repressor Proteins; Trans-Activators | 2020 |
Binding and allosteric transmission of histone H3 Lys-4 trimethylation to the recombinase RAG-1 are separable functions of the RAG-2 plant homeodomain finger.
Topics: Allosteric Regulation; Animals; Binding Sites; Chromatin; DNA-Binding Proteins; Histones; Homeodomain Proteins; Lysine; Methylation; Mice; Phylogeny; Protein Binding; Recombinases; Sharks; Substrate Specificity; V(D)J Recombination; VDJ Recombinases | 2020 |
Splicing- and demethylase-independent functions of LSD1 in zebrafish primitive hematopoiesis.
Topics: Amino Acid Sequence; Animals; Cells, Cultured; Embryo, Nonmammalian; Hematopoiesis; Histone Demethylases; Humans; Lysine; Methylation; Mutation; Protein Isoforms; RNA Splicing; Sequence Homology; Zebrafish; Zebrafish Proteins | 2020 |
Structural Basis for the Binding Selectivity of Human CDY Chromodomains.
Topics: Amino Acid Motifs; Animals; Binding Sites; Histones; Humans; Lysine; Methylation; Mice; Mice, Inbred ICR; Molecular Dynamics Simulation; Neurons; Nuclear Proteins; Peptidomimetics; Protein Binding; Protein Domains; Protein Subunits | 2020 |
H3K36 dimethylation by MMSET promotes classical non-homologous end-joining at unprotected telomeres.
Topics: Animals; Cells, Cultured; DNA Breaks, Double-Stranded; DNA End-Joining Repair; Embryo, Mammalian; Fibroblasts; HEK293 Cells; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Mice, Knockout; Repressor Proteins; RNA Interference; Telomere | 2020 |
Host-Guest Protein Assembly for Affinity Purification of Methyllysine Proteomes.
Topics: Amantadine; Bridged-Ring Compounds; Chromatography, Affinity; Chromobox Protein Homolog 5; Chromosomal Proteins, Non-Histone; HeLa Cells; Humans; Imidazoles; Lysine; Methylation; Neoplasms; Peptides | 2020 |
Global analysis of histone modifications and long-range chromatin interactions revealed the differential cistrome changes and novel transcriptional players in human dilated cardiomyopathy.
Topics: Base Sequence; Cardiomyopathy, Dilated; Chromatin; DNA-Binding Proteins; Enhancer Elements, Genetic; Epigenesis, Genetic; Gene Ontology; Genome, Human; Heart Failure; Heart Ventricles; Histones; Humans; Lysine; Male; Methylation; Muscle Proteins; Nucleotide Motifs; Promoter Regions, Genetic; Protein Processing, Post-Translational; Transcription Factors | 2020 |
High methylation levels of histone H3 lysine 9 associated with activation of hypoxia-inducible factor 1α (HIF-1α) predict patients' worse prognosis in human hepatocellular carcinomas.
Topics: Carcinoma, Hepatocellular; Cell Nucleus; Gene Expression Regulation, Neoplastic; Histones; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Liver Neoplasms; Lysine; Methylation; Prognosis; Retrospective Studies; Survival Analysis; Tissue Array Analysis; Up-Regulation | 2020 |
The lncRNA LAMP5-AS1 drives leukemia cell stemness by directly modulating DOT1L methyltransferase activity in MLL leukemia.
Topics: Animals; Cell Self Renewal; Child, Preschool; Female; Gene Expression Regulation, Leukemic; Genetic Vectors; Heterografts; Histone-Lysine N-Methyltransferase; Histones; Homeodomain Proteins; Humans; Infant; Leukemia, Myeloid, Acute; Lysine; Lysosomal Membrane Proteins; Male; Methylation; Mice; Mice, Inbred NOD; Mice, SCID; Myeloid-Lymphoid Leukemia Protein; Neoplastic Stem Cells; Oncogene Proteins, Fusion; Precursor B-Cell Lymphoblastic Leukemia-Lymphoma; Primary Cell Culture; Protein Processing, Post-Translational; Recombinant Fusion Proteins; RNA Interference; RNA, Antisense; RNA, Messenger; RNA, Neoplasm; RNA, Small Interfering; Specific Pathogen-Free Organisms; Tumor Cells, Cultured; Tumor Stem Cell Assay | 2020 |
Nucleosome Binding by the Lysine Specific Demethylase 1 (LSD1) Enzyme Enables Histone H3 Demethylation.
Topics: Histone Demethylases; Histones; Humans; Lysine; Methylation; Models, Molecular; Nucleosomes; Protein Binding; Protein Processing, Post-Translational | 2020 |
NeuroD1 Dictates Tumor Cell Differentiation in Medulloblastoma.
Topics: Animals; Basic Helix-Loop-Helix Transcription Factors; Carcinogenesis; Cell Differentiation; Cell Line, Tumor; Cell Proliferation; Cerebellar Neoplasms; Enhancer of Zeste Homolog 2 Protein; Hedgehog Proteins; Histones; Humans; Lysine; Medulloblastoma; Methylation; Mice; Nerve Tissue Proteins; Neurons; Patched-1 Receptor; Signal Transduction; Single-Cell Analysis | 2020 |
Methyltransferase-like 21C (METTL21C) methylates alanine tRNA synthetase at Lys-943 in muscle tissue.
Topics: Animals; HEK293 Cells; Humans; Lysine; Methylation; Methyltransferases; Mice; Models, Molecular; Muscle, Skeletal; Muscles | 2020 |
Dietary glutamine supplementation suppresses epigenetically-activated oncogenic pathways to inhibit melanoma tumour growth.
Topics: Animals; Cell Line, Tumor; Cell Proliferation; Dietary Supplements; Epigenesis, Genetic; Glutamine; Histones; Humans; Lysine; Male; Melanoma; Methylation; Mice, Nude; Signal Transduction; Transcriptome; Xenograft Model Antitumor Assays | 2020 |
MicroRNA-200a Inhibits Inflammation and Atherosclerotic Lesion Formation by Disrupting EZH2-Mediated Methylation of STAT3.
Topics: Animals; Apoptosis; Atherosclerosis; Cells, Cultured; Disease Models, Animal; Enhancer of Zeste Homolog 2 Protein; Human Umbilical Vein Endothelial Cells; Humans; Inflammation; Lipoproteins, LDL; Lysine; Male; Methylation; Mice, Knockout, ApoE; MicroRNAs; Phosphorylation; Plaque, Atherosclerotic; Signal Transduction; STAT3 Transcription Factor | 2020 |
Proteome-wide Prediction of Lysine Methylation Leads to Identification of H2BK43 Methylation and Outlines the Potential Methyllysine Proteome.
Topics: Algorithms; Amino Acid Sequence; Animals; Cell Differentiation; Demethylation; Female; Histones; Humans; Jumonji Domain-Containing Histone Demethylases; Lysine; MCF-7 Cells; Methylation; Mice; Mouse Embryonic Stem Cells; Neurons; Nuclear Proteins; Proteome; Repressor Proteins; Software; Substrate Specificity | 2020 |
Direct readout of heterochromatic H3K9me3 regulates DNMT1-mediated maintenance DNA methylation.
Topics: DNA (Cytosine-5-)-Methyltransferase 1; DNA Methylation; Heterochromatin; Histones; Humans; Lysine; Methylation; Protein Processing, Post-Translational | 2020 |
UTX Regulates Human Neural Differentiation and Dendritic Morphology by Resolving Bivalent Promoters.
Topics: Base Sequence; Cell Differentiation; Cell Line; Cell Lineage; Cell Self Renewal; Dendrites; Electrophysiological Phenomena; Histone Demethylases; Histones; Human Embryonic Stem Cells; Humans; Lysine; Methylation; Neurites; Promoter Regions, Genetic; Transcription, Genetic; Up-Regulation | 2020 |
Loss of histone H3 trimethylation on lysine 27 and nuclear expression of transducin-like enhancer 1 in primary intracranial sarcoma, DICER1-mutant.
Topics: Adolescent; Aged; Biomarkers, Tumor; Brain Neoplasms; Child; DEAD-box RNA Helicases; Female; High-Throughput Nucleotide Sequencing; Histones; Humans; Immunohistochemistry; Infant; Lysine; Male; Methylation; Mutation; Ribonuclease III; Sarcoma; Transducin | 2021 |
Phase separation of Arabidopsis EMB1579 controls transcription, mRNA splicing, and development.
Topics: Arabidopsis; Arabidopsis Proteins; Calcium-Binding Proteins; Cell Nucleus; Flowers; Histones; Loss of Function Mutation; Lysine; Methylation; Nuclear Proteins; Phenotype; Plant Development; Plant Roots; Protein Binding; Repetitive Sequences, Amino Acid; RNA Splicing; RNA, Messenger; Transcription, Genetic | 2020 |
Crystal Structure of MLL2 Complex Guides the Identification of a Methylation Site on P53 Catalyzed by KMT2 Family Methyltransferases.
Topics: Catalysis; Catalytic Domain; Crystallography, X-Ray; DNA-Binding Proteins; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Multiprotein Complexes; Neoplasm Proteins; Nuclear Proteins; Protein Domains; Substrate Specificity; Transcription Factors; Tumor Suppressor Protein p53 | 2020 |
Upregulation of histone H3K9 methylation in fetal endothelial cells from preeclamptic pregnancies.
Topics: Adult; Cell Hypoxia; Down-Regulation; Endothelial Cells; Female; Fetus; Histocompatibility Antigens; Histone-Lysine N-Methyltransferase; Histones; Human Umbilical Vein Endothelial Cells; Humans; Lysine; Methylation; Nitric Oxide Synthase Type III; Oxidative Stress; Placenta; Pre-Eclampsia; Pregnancy; Superoxide Dismutase; Up-Regulation | 2021 |
Living under Strain: How Epithelia Protect Their Genomes from Repeated Stretching.
Topics: Animals; Cellular Microenvironment; DNA; DNA Damage; Epithelium; Extracellular Matrix; Genome; Genomic Instability; Histones; Humans; Lysine; Methylation; Stem Cells; Stress, Mechanical | 2020 |
Histone Methylation: Achilles Heel and Powerful Mediator of Periodontal Homeostasis.
Topics: DNA Methylation; Epigenesis, Genetic; Histones; Homeostasis; Lysine; Methylation; Protein Processing, Post-Translational | 2020 |
Integrated Metabolic and Epigenomic Reprograming by H3K27M Mutations in Diffuse Intrinsic Pontine Gliomas.
Topics: Animals; Brain Stem Neoplasms; Cell Line, Tumor; Diffuse Intrinsic Pontine Glioma; Epigenomics; Gene Expression Regulation, Neoplastic; Glycolysis; Histones; Humans; Lysine; Methylation; Mice, Inbred NOD; Mice, Knockout; Mice, Nude; Mice, SCID; Mutation; Transplantation, Heterologous | 2020 |
Focal Adhesion Kinase (FAK) Over-Expression and Prognostic Implication in Pediatric Hepatocellular Carcinoma.
Topics: beta Catenin; Carcinoma, Hepatocellular; Cell Nucleus; Child; Enhancer of Zeste Homolog 2 Protein; Female; Focal Adhesion Protein-Tyrosine Kinases; Gene Expression Regulation, Neoplastic; Histones; Humans; Liver Cirrhosis; Liver Neoplasms; Lysine; Male; Methylation; Phosphorylation; Phosphotyrosine; Prognosis; Proliferating Cell Nuclear Antigen; Tumor Burden; Up-Regulation | 2020 |
Long noncoding RNA Hotair facilitates retinal endothelial cell dysfunction in diabetic retinopathy.
Topics: Animals; Antigens, CD; Cadherins; Diabetic Retinopathy; Endothelial Cells; Gene Expression Regulation; Gene Knockdown Techniques; Glucose; Histone Demethylases; Histones; Hypoxia-Inducible Factor 1, alpha Subunit; Lysine; Male; Methylation; Mice, Inbred C57BL; Promoter Regions, Genetic; Retina; Retinal Vessels; RNA, Long Noncoding; Vascular Endothelial Growth Factor A | 2020 |
E6 hijacks KDM5C/lnc_000231/miR-497-5p/CCNE1 axis to promote cervical cancer progression.
Topics: Acetylation; Animals; Base Sequence; Carcinogenesis; Cell Cycle; Cell Line, Tumor; Cell Proliferation; Cyclin E; Disease Progression; Down-Regulation; Female; Gene Expression Regulation, Neoplastic; Histone Demethylases; Histones; Humans; Lysine; Methylation; Mice, Inbred BALB C; Mice, Nude; MicroRNAs; Oncogene Proteins; Oncogene Proteins, Viral; Promoter Regions, Genetic; Protein Stability; RNA, Long Noncoding; Tumor Stem Cell Assay; Up-Regulation; Uterine Cervical Neoplasms | 2020 |
Estrogen Induces Selective Transcription of Caveolin1 Variants in Human Breast Cancer through Estrogen Responsive Element-Dependent Mechanisms.
Topics: Adult; Aged; Breast Neoplasms; Caveolin 1; Cell Line, Tumor; Estradiol; Female; Gene Expression Regulation, Neoplastic; Histones; Humans; Lysine; Methylation; Middle Aged; Receptors, Estrogen; Response Elements | 2020 |
The catalytic domain of the histone methyltransferase NSD2/MMSET is required for the generation of B1 cells in mice.
Topics: Animals; Animals, Newborn; B-Lymphocytes; Catalytic Domain; Germinal Center; Histone-Lysine N-Methyltransferase; Histones; Immunity, Humoral; Immunoglobulin Class Switching; Lysine; Methylation; Mice, Inbred C57BL; Structure-Activity Relationship; Survival Analysis | 2020 |
Somatic mutations in colorectal cancer are associated with the epigenetic modifications.
Topics: Base Pairing; Base Sequence; Binding Sites; CCCTC-Binding Factor; Chromatin; Colorectal Neoplasms; CpG Islands; DNA Methylation; Enhancer Elements, Genetic; Epigenesis, Genetic; Genome, Human; HCT116 Cells; Histones; Humans; Lysine; Methylation; MicroRNAs; Mutation | 2020 |
H3K4 Methylation Status and Lysine Specific Methyltransferase KMT2C Expression Correlate with Prognosis in Lung Adenocarcinoma.
Topics: Adenocarcinoma of Lung; DNA-Binding Proteins; Female; Histones; Humans; Lung Neoplasms; Lysine; Methylation; Methyltransferases; Prognosis | 2021 |
The long non-coding RNA SNHG1 promotes bladder cancer progression by interacting with miR-143-3p and EZH2.
Topics: Animals; Antigens, CD; Base Sequence; Cadherins; Carcinogenesis; Cell Line, Tumor; Cell Movement; Cell Nucleus; Cell Proliferation; Cytoplasm; Disease Progression; Enhancer of Zeste Homolog 2 Protein; Epigenesis, Genetic; Female; Gene Expression Regulation, Neoplastic; Gene Silencing; Hexokinase; Histones; Humans; Lysine; Male; Methylation; Mice, Inbred BALB C; Mice, Nude; MicroRNAs; Middle Aged; Models, Biological; Neoplasm Invasiveness; Neoplasm Metastasis; RNA, Long Noncoding; Transcription, Genetic; Up-Regulation; Urinary Bladder Neoplasms | 2020 |
PRC2 Acts as a Critical Timer That Drives Oligodendrocyte Fate over Astrocyte Identity by Repressing the Notch Pathway.
Topics: Animals; Astrocytes; Cell Differentiation; Cell Lineage; Chickens; Enhancer of Zeste Homolog 2 Protein; Histones; Lysine; Methylation; Mice; Myelin Sheath; NFI Transcription Factors; Oligodendroglia; Polycomb Repressive Complex 2; Receptors, Notch; Signal Transduction; Spinal Cord; Stem Cells; Wnt Signaling Pathway | 2020 |
Sequence specificity analysis of the SETD2 protein lysine methyltransferase and discovery of a SETD2 super-substrate.
Topics: Amino Acid Sequence; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Mutation; Peptides; Protein Processing, Post-Translational; Substrate Specificity | 2020 |
The Huntingtin-interacting protein SETD2/HYPB is an actin lysine methyltransferase.
Topics: Actins; Cytoskeleton; GTP-Binding Proteins; Histone-Lysine N-Methyltransferase; Lysine; Methylation; Protein Processing, Post-Translational | 2020 |
TASOR is a pseudo-PARP that directs HUSH complex assembly and epigenetic transposon control.
Topics: Amino Acid Sequence; Antigens, Neoplasm; Binding Sites; DNA Transposable Elements; Epigenesis, Genetic; Exons; Genome; HEK293 Cells; HeLa Cells; Histones; Humans; Lysine; Magnetic Resonance Spectroscopy; Methylation; Multiprotein Complexes; NAD; Nuclear Proteins; Phosphoproteins; Poly(ADP-ribose) Polymerases; Protein Binding; Protein Domains; RNA; RNA Processing, Post-Transcriptional; Transcription, Genetic | 2020 |
Novel Formaldehyde-Induced Modifications of Lysine Residue Pairs in Peptides and Proteins: Identification and Relevance to Vaccine Development.
Topics: Aldehydes; Chromatography, High Pressure Liquid; Cross-Linking Reagents; Cytochromes c; Deamination; Formaldehyde; Kinetics; Lysine; Magnetic Resonance Spectroscopy; Mass Spectrometry; Methylation; Molecular Structure; Peptides; Vaccines, Inactivated | 2020 |
An optogenetic switch for the Set2 methyltransferase provides evidence for transcription-dependent and -independent dynamics of H3K36 methylation.
Topics: Genome, Fungal; Histone Code; Histone Demethylases; Histones; Lysine; Methylation; Methyltransferases; Models, Statistical; Optogenetics; Repressor Proteins; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Transcription, Genetic | 2020 |
SUV39H1 regulates the progression of MLL-AF9-induced acute myeloid leukemia.
Topics: Animals; Apoptosis; Cell Line, Tumor; Cell Transformation, Neoplastic; Disease Progression; Female; Gene Expression Regulation, Neoplastic; Hematopoietic Stem Cells; Histones; Humans; Leukemia, Myeloid, Acute; Lysine; Methylation; Methyltransferases; Mice; Myeloid-Lymphoid Leukemia Protein; Oncogene Proteins, Fusion; Repressor Proteins; Transcription, Genetic | 2020 |
SETDB1 mediated histone H3 lysine 9 methylation suppresses MLL-fusion target expression and leukemic transformation.
Topics: Animals; Histone-Lysine N-Methyltransferase; Histones; Homeodomain Proteins; Humans; Leukemia, Myeloid, Acute; Lysine; Methylation; Mice; Myeloid-Lymphoid Leukemia Protein; Oncogene Proteins, Fusion | 2020 |
Histone H3.3 G34 mutations promote aberrant PRC2 activity and drive tumor progression.
Topics: Chromatin; Gene Expression; Gene Expression Regulation; Glioma; HEK293 Cells; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Mesenchymal Stem Cells; Methylation; Mutation; Neoplastic Processes; Polycomb Repressive Complex 1; Polycomb Repressive Complex 2; Protein Processing, Post-Translational | 2020 |
Sperm histone H3 lysine 4 trimethylation is altered in a genetic mouse model of transgenerational epigenetic inheritance.
Topics: Animals; Cellular Reprogramming; Chromatin; Chromatin Immunoprecipitation Sequencing; Embryo, Mammalian; Epigenesis, Genetic; Gene Ontology; Genetic Loci; Histone Demethylases; Histones; Lysine; Male; Methylation; Mice; Mice, Inbred C57BL; Mice, Transgenic; Phenotype; Promoter Regions, Genetic; Spermatocytes; Spermatogenesis; Spermatozoa | 2020 |
DOT1L-controlled cell-fate determination and transcription elongation are independent of H3K79 methylation.
Topics: Cell Differentiation; Cell Proliferation; DNA Methylation; Embryonic Stem Cells; Epigenesis, Genetic; Epigenomics; Gene Expression Regulation; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Methyltransferases; Neural Stem Cells; Protein Processing, Post-Translational; Transcription Elongation, Genetic; Transcriptional Elongation Factors | 2020 |
The histone and non-histone methyllysine reader activities of the UHRF1 tandem Tudor domain are dispensable for the propagation of aberrant DNA methylation patterning in cancer cells.
Topics: CCAAT-Enhancer-Binding Proteins; DNA Methylation; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; HCT116 Cells; HeLa Cells; Histone Code; Histones; Humans; Lysine; Methylation; Protein Processing, Post-Translational; Tudor Domain; Ubiquitin-Protein Ligases | 2020 |
JARID1B promotes colorectal cancer proliferation and Wnt/β-catenin signaling via decreasing CDX2 level.
Topics: Animals; Carcinogenesis; CDX2 Transcription Factor; Cell Line, Tumor; Cell Proliferation; Colorectal Neoplasms; Disease Progression; Down-Regulation; Gene Expression Regulation, Neoplastic; Histones; Humans; Jumonji Domain-Containing Histone Demethylases; Lysine; Male; Methylation; Mice, Inbred BALB C; Mice, Nude; Middle Aged; Multivariate Analysis; Nuclear Proteins; Promoter Regions, Genetic; Repressor Proteins; Survival Analysis; Up-Regulation; Wnt Signaling Pathway | 2020 |
Broad genic repression domains signify enhanced silencing of oncogenes.
Topics: Breast Neoplasms; CD4-Positive T-Lymphocytes; Cell Line, Tumor; Cell Movement; Cell Proliferation; Chromatin; Conserved Sequence; Female; Gene Expression Regulation, Neoplastic; Gene Silencing; Histones; Humans; Lysine; Methylation; Nucleotide Motifs; Oncogenes; Regulatory Sequences, Nucleic Acid; RNA, Long Noncoding; Transcription Elongation, Genetic; Transcription Initiation, Genetic | 2020 |
Metabolic Reprogramming Induces Germinal Center B Cell Differentiation through Bcl6 Locus Remodeling.
Topics: Animals; B-Lymphocytes; Cell Differentiation; Citric Acid Cycle; Enhancer Elements, Genetic; Epigenesis, Genetic; Genetic Loci; Germinal Center; Histone Demethylases; Histones; Humans; Interleukin-4; Ketoglutaric Acids; Lysine; Metabolome; Metabolomics; Methylation; Mice, Inbred C57BL; Mitochondria; Oxidation-Reduction; Proto-Oncogene Proteins c-bcl-6; Signal Transduction; STAT6 Transcription Factor; Transcription, Genetic | 2020 |
Residues flanking the ARK
Topics: Amino Acid Sequence; Chromobox Protein Homolog 5; Chromosomal Proteins, Non-Histone; Histocompatibility Antigens; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Molecular Dynamics Simulation; Protein Binding; Protein Interaction Domains and Motifs; Protein Processing, Post-Translational | 2021 |
Highly Efficient Separation of Methylated Peptides Utilizing Selective Complexation between Lysine and 18-Crown-6.
Topics: Animals; Cattle; Crown Ethers; Lysine; Methylation; Peptides; Proteolysis; Serum Albumin, Bovine; Trypsin | 2020 |
H3K27M in Gliomas Causes a One-Step Decrease in H3K27 Methylation and Reduced Spreading within the Constraints of H3K36 Methylation.
Topics: Cell Line, Tumor; Chromatin; DNA Methylation; Epigenomics; Gene Expression; Gene Expression Regulation, Neoplastic; Glioma; Histones; Humans; Lysine; Methionine; Methylation; Mutation; Polycomb Repressive Complex 2; Protein Processing, Post-Translational | 2020 |
Maternal DOT1L is dispensable for mouse development.
Topics: Animals; Blastocyst; Cell Proliferation; Embryo, Mammalian; Embryonic Development; Histone Methyltransferases; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Mice; Mice, Knockout; Mice, Transgenic; Models, Animal; Oocytes; Zygote | 2020 |
Trans- and cis-acting effects of Firre on epigenetic features of the inactive X chromosome.
Topics: Alleles; Animals; Base Sequence; Cell Line; Cell Nucleus; Chromatin; DNA, Complementary; Epigenesis, Genetic; Female; Gene Deletion; Gene Ontology; Genetic Loci; Genome; Histones; Lysine; Male; Methylation; Mice, Inbred C57BL; Polycomb Repressive Complex 2; RNA, Long Noncoding; Transgenes; Up-Regulation; X Chromosome; X Chromosome Inactivation | 2020 |
Epigenetic activation of a RAS/MYC axis in H3.3K27M-driven cancer.
Topics: Animals; Brain Neoplasms; Disease Models, Animal; Epigenesis, Genetic; Epigenomics; Gene Expression Profiling; Gene Expression Regulation, Neoplastic; Glioma; Histones; Humans; Lysine; Methylation; Mice, Knockout; Proto-Oncogene Proteins c-myc; ras Proteins; Tumor Suppressor Protein p53 | 2020 |
Coupling of H3K27me3 recognition with transcriptional repression through the BAH-PHD-CPL2 complex in Arabidopsis.
Topics: Arabidopsis; Arabidopsis Proteins; Epigenesis, Genetic; Flowers; Gene Expression Regulation, Developmental; Gene Expression Regulation, Plant; Histone Code; Histones; Lysine; Methylation; Models, Molecular; Multiprotein Complexes; Phosphoprotein Phosphatases; Protein Conformation; Time Factors | 2020 |
Fine-tuning of lysine side chain modulates the activity of histone lysine methyltransferases.
Topics: Histone-Lysine N-Methyltransferase; Humans; Lysine; Methylation; Protein Conformation | 2020 |
Predictive QM/MM Modeling of Modulations in Protein-Protein Binding by Lysine Methylation.
Topics: Binding Sites; Carrier Proteins; Hydrogen Bonding; Lysine; Methylation; Molecular Docking Simulation; Molecular Dynamics Simulation; Protein Binding; Proteins; Solvents; Structure-Activity Relationship | 2021 |
Long noncoding RNA ATB promotes ovarian cancer tumorigenesis by mediating histone H3 lysine 27 trimethylation through binding to EZH2.
Topics: Carcinogenesis; Cell Line, Tumor; Cell Movement; Cell Proliferation; Enhancer of Zeste Homolog 2 Protein; Female; Gene Expression Regulation, Neoplastic; Gene Silencing; Histones; Humans; Lysine; Methylation; Models, Biological; Neoplasm Invasiveness; Ovarian Neoplasms; Protein Binding; RNA, Long Noncoding; Treatment Outcome | 2021 |
Selective Triazenation Reaction (STaR) of Secondary Amines for Tagging Monomethyl Lysine Post-Translational Modifications.
Topics: Amines; Lysine; Methylation; Molecular Structure; Peptides; Protein Processing, Post-Translational | 2021 |
FBXO44 promotes DNA replication-coupled repetitive element silencing in cancer cells.
Topics: Adult; Cell Line, Tumor; Cell Proliferation; Cell Survival; DNA Breaks, Double-Stranded; DNA Replication; Drug Resistance, Neoplasm; F-Box Proteins; Female; Gene Expression Regulation, Neoplastic; Histones; Humans; Immune Checkpoint Inhibitors; Immunity; Interferons; Lysine; Male; Methylation; Middle Aged; Neoplasm Proteins; Neoplasms; Nucleosomes; Repetitive Sequences, Nucleic Acid; Signal Transduction; Transcription, Genetic; Treatment Outcome | 2021 |
Using Machine Learning and Targeted Mass Spectrometry to Explore the Methyl-Lys Proteome.
Topics: Algorithms; Forecasting; Humans; Lysine; Machine Learning; Mass Spectrometry; Methylation; Protein Processing, Post-Translational; Proteome; Sequence Analysis, Protein; Software | 2020 |
Histone H3Q5 serotonylation stabilizes H3K4 methylation and potentiates its readout.
Topics: Chromatin; Glutamine; Histones; Humans; Lysine; Methylation; Protein Binding; Protein Processing, Post-Translational; Serotonergic Neurons | 2021 |
Histone modification dynamics at H3K27 are associated with altered transcription of in planta induced genes in Magnaporthe oryzae.
Topics: Acetylation; Ascomycota; Gene Expression Regulation, Plant; Genomics; Histone Code; Histones; Host-Pathogen Interactions; Lysine; Methylation; Plants; RNA-Seq; Transcription, Genetic | 2021 |
Histone modifications form a cell-type-specific chromosomal bar code that persists through the cell cycle.
Topics: Acetylation; Cell Cycle; Chromatin; Chromosomes; Epigenesis, Genetic; HeLa Cells; Histone Code; Histones; Humans; Lysine; Methylation; Mitosis; Nucleosomes; Protein Processing, Post-Translational | 2021 |
The Temporal Order of DNA Replication Shaped by Mammalian DNA Methyltransferases.
Topics: Animals; Chromosomes, Mammalian; DNA; DNA Methylation; DNA Replication Timing; Genome; Heterochromatin; Histones; Lysine; Mammals; Methylation; Methyltransferases; Mice; Mice, Knockout; Mouse Embryonic Stem Cells; Transcription, Genetic | 2021 |
Depletion of H3K36me2 recapitulates epigenomic and phenotypic changes induced by the H3.3K36M oncohistone mutation.
Topics: Animals; Antimetabolites, Antineoplastic; Carcinogenesis; Cell Line; Chromatin; CRISPR-Cas Systems; Cytarabine; Decitabine; Epigenesis, Genetic; Gene Editing; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Mesenchymal Stem Cells; Methylation; Mice; Mutation; Neoplasm Proteins; Neoplasms; Phenotype; Protein Isoforms; Protein Processing, Post-Translational; Repressor Proteins; Transcriptome | 2021 |
Rice and Arabidopsis homologs of yeast CHROMOSOME TRANSMISSION FIDELITY PROTEIN 4 commonly interact with Polycomb complexes but exert divergent regulatory functions.
Topics: Arabidopsis; Cell Nucleus; DNA Damage; DNA Polymerase I; DNA-Binding Proteins; Flowers; Histones; Lysine; Methylation; Mutation; Oryza; Phenotype; Plant Proteins; Polycomb-Group Proteins; Protein Binding; S Phase; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins; Sequence Homology, Amino Acid | 2021 |
Lysines Acetylome and Methylome Profiling of H3 and H4 Histones in Trichostatin A-Treated Stem Cells.
Topics: Acetylation; Amino Acid Sequence; Animals; Dimethyl Sulfoxide; Embryonic Stem Cells; Gene Expression Regulation; Histones; Hydroxamic Acids; Lysine; Methylation; Mice; Octamer Transcription Factor-3; Peptides; Peroxiredoxins; Protein Processing, Post-Translational; Proteolysis | 2021 |
Chemical Depletion of Histidine-Containing Peptides Allows Identification of More Low-Abundance Methylation Sites from Proteome Samples.
Topics: Arginine; Histidine; Lysine; Methylation; Peptides; Protein Processing, Post-Translational; Proteome | 2021 |
Full methylation of H3K27 by PRC2 is dispensable for initial embryoid body formation but required to maintain differentiated cell identity.
Topics: Animals; Cell Differentiation; Cell Line; Embryoid Bodies; Embryonic Stem Cells; Enhancer of Zeste Homolog 2 Protein; Histones; Indazoles; Lysine; Methylation; Mice; Phenotype; Polycomb Repressive Complex 2; Protein Processing, Post-Translational; Pyridones; Transcriptome | 2021 |
Methylation-dependent SUMOylation of the architectural transcription factor HMGA2.
Topics: Amino Acid Motifs; Amino Acid Sequence; Binding Sites; Cell Line; HMGA2 Protein; Humans; Lysine; Methylation; Protein Binding; Protein Domains; Sequence Homology, Amino Acid; Sumoylation; Transcription Factors; Ubiquitin-Conjugating Enzymes | 2021 |
Tunable, division-independent control of gene activation timing by a polycomb switch.
Topics: Animals; Cell Division; Cell Lineage; Epigenesis, Genetic; Genetic Loci; Histones; Humans; Lysine; Methylation; Mice, Inbred C57BL; Polycomb-Group Proteins; Protein Conformation; Repressor Proteins; T-Lymphocytes; Time Factors; Transcription Factors; Transcriptional Activation; Tumor Suppressor Proteins | 2021 |
H3.1K27me1 maintains transcriptional silencing and genome stability by preventing GCN5-mediated histone acetylation.
Topics: Acetylation; Arabidopsis; Arabidopsis Proteins; Gene Silencing; Genome, Plant; Genomic Instability; Heterochromatin; Histone Acetyltransferases; Histones; Lysine; Methylation; Methyltransferases; Mutation; Plants, Genetically Modified; Transcription Factors | 2021 |
Combinatorial Histone H3 Modifications Are Dynamically Altered in Distinct Cell Cycle Phases.
Topics: Cell Cycle; Chromatography, Reverse-Phase; HeLa Cells; Histones; Humans; Lysine; Methylation; Protein Processing, Post-Translational; Tandem Mass Spectrometry; Workflow | 2021 |
Arginine and lysine methylation of MRPS23 promotes breast cancer metastasis through regulating OXPHOS.
Topics: Arginine; Breast Neoplasms; Cell Line, Tumor; Cell Proliferation; Female; Humans; Lysine; Methylation; Mitochondria; Neoplasm Metastasis; Organoids; Oxidative Phosphorylation; Protein Methyltransferases; Protein Processing, Post-Translational; Protein-Arginine N-Methyltransferases | 2021 |
Prenatal nicotine exposure leads to decreased histone H3 lysine 9 (H3K9) methylation and increased
Topics: Animals; Female; Histones; Lysine; Methylation; Nicotine; Pancreas; Pregnancy; Rats; Src Homology 2 Domain-Containing, Transforming Protein 1 | 2022 |
Dynamic methylation of histone H3K18 in differentiating Theileria parasites.
Topics: Acetylation; Animals; Cattle; Cell Line; Chickens; Chromatin Immunoprecipitation Sequencing; Epigenetic Repression; Gene Expression Regulation, Developmental; HEK293 Cells; Histones; Humans; Insect Proteins; Life Cycle Stages; Lysine; Methylation; Methyltransferases; Mutagenesis, Site-Directed; Peptides, Cyclic; Recombinant Proteins; RNA-Seq; Theileria; Theileriasis; Tranylcypromine | 2021 |
A histone H3K4me1-specific binding protein is required for siRNA accumulation and DNA methylation at a subset of loci targeted by RNA-directed DNA methylation.
Topics: Arabidopsis; Arabidopsis Proteins; Chromatin; Chromatin Immunoprecipitation Sequencing; DNA Methylation; DNA-Directed RNA Polymerases; Gene Expression Regulation, Plant; Histones; Lysine; Methylation; Plants, Genetically Modified; Protein Binding; Protein Conformation; RNA Interference; RNA, Small Interfering; Whole Genome Sequencing | 2021 |
The dynamic epigenetic regulation of the inactive X chromosome in healthy human B cells is dysregulated in lupus patients.
Topics: Adolescent; Adult; Alleles; B-Lymphocytes; Child; Chromosomes, Human, X; Epigenesis, Genetic; Gene Expression Profiling; Heterochromatin; Histones; Humans; Lupus Erythematosus, Systemic; Lymphocyte Subsets; Lysine; Methylation; Middle Aged; RNA, Long Noncoding; Ubiquitin; X Chromosome Inactivation; Young Adult | 2021 |
Heteromeric HSFA2/HSFA3 complexes drive transcriptional memory after heat stress in Arabidopsis.
Topics: Arabidopsis; Arabidopsis Proteins; Epistasis, Genetic; Gene Expression Regulation, Plant; Genes, Plant; Genetic Loci; Heat Shock Transcription Factors; Heat-Shock Response; Histones; Kinetics; Lysine; Methylation; Multiprotein Complexes; Plants, Genetically Modified; Promoter Regions, Genetic; Protein Binding; RNA, Messenger; Transcription, Genetic | 2021 |
γ-Difluorolysine as a
Topics: Acetylation; Histone Acetyltransferases; Histone-Lysine N-Methyltransferase; Lysine; Magnetic Resonance Spectroscopy; Methylation | 2021 |
Asymmetrical deposition and modification of histone H3 variants are essential for zygote development.
Topics: Animals; DNA Replication; Female; Gene Expression Regulation, Developmental; Histone Code; Histones; Lysine; Male; Methylation; Mice; Zygote | 2021 |
Lysine methylation shields an intracellular pathogen from ubiquitylation and autophagy.
Topics: Animals; Autophagy; Lysine; Methylation; Mice; Ubiquitin; Ubiquitination | 2021 |
Comparative distributions of RSBN1 and methylated histone H4 Lysine 20 in the mouse spermatogenesis.
Topics: Animals; Cell Differentiation; Cell Nucleus; Germ Cells; Histones; Homeodomain Proteins; Lysine; Male; Methylation; Mice; Seminal Plasma Proteins; Spermatogenesis; Testis | 2021 |
A chromodomain protein mediates heterochromatin-directed piRNA expression.
Topics: Animals; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Chromatin Assembly and Disassembly; Genetic Testing; Germ Cells; Heterochromatin; Histones; Lysine; Methylation; Peptides; Polycomb Repressive Complex 2; Protein Binding; RNA, Small Interfering; Temperature | 2021 |
The nuclear kinesin KIF18B promotes 53BP1-mediated DNA double-strand break repair.
Topics: Amino Acid Motifs; Amino Acid Sequence; Cell Line, Tumor; Cell Nucleus; DNA Breaks, Double-Stranded; HEK293 Cells; Histones; Humans; Kinesins; Lysine; Methylation; Protein Binding; Tumor Suppressor p53-Binding Protein 1 | 2021 |
SETD7-mediated monomethylation is enriched on soluble Tau in Alzheimer's disease.
Topics: Alzheimer Disease; Animals; Histone-Lysine N-Methyltransferase; Humans; Lysine; Methylation; Mice; Mice, Transgenic; Protein Processing, Post-Translational; tau Proteins | 2021 |
Kdm3b haploinsufficiency impairs the consolidation of cerebellum-dependent motor memory in mice.
Topics: Animals; Cerebellum; Gene Expression Regulation; Haploinsufficiency; Histones; Jumonji Domain-Containing Histone Demethylases; Lysine; Male; Memory Consolidation; Methylation; Mice, Inbred C57BL; Motor Activity | 2021 |
α-TubK40me3 is required for neuronal polarization and migration by promoting microtubule formation.
Topics: Acetylation; Animals; Cell Movement; Cerebral Cortex; Cytokinesis; Gene Knockdown Techniques; Histone-Lysine N-Methyltransferase; Lysine; Methylation; Mice; Microtubules; Mitosis; Neurogenesis; Neurons; Paclitaxel; Protein Processing, Post-Translational; Tubulin | 2021 |
Role of Dot1L and H3K79 methylation in regulating somatic hypermutation of immunoglobulin genes.
Topics: Animals; B-Lymphocytes; Burkitt Lymphoma; Cell Line, Tumor; Histone-Lysine N-Methyltransferase; Histones; Humans; Immunoglobulin Class Switching; Immunoglobulin Constant Regions; Immunoglobulin Heavy Chains; Immunoglobulin Variable Region; Lysine; Methylation; Mice; Somatic Hypermutation, Immunoglobulin | 2021 |
Lysine Demethylase 5A is Required for MYC Driven Transcription in Multiple Myeloma.
Topics: Cyclin-Dependent Kinase 9; Cyclin-Dependent Kinase-Activating Kinase; Cyclin-Dependent Kinases; Genes, cdc; Humans; Lysine; Methylation; Multiple Myeloma; Proto-Oncogene Proteins c-myc; Retinoblastoma-Binding Protein 2; RNA Polymerase II | 2021 |
Tubulin methylation of lysine 40 by SETD2: a new way to tune neuronal functions?
Topics: Histones; Humans; Lysine; Methylation; Protein Processing, Post-Translational; Tubulin | 2021 |
Histone and DNA binding ability studies of the NSD subfamily of PWWP domains.
Topics: Amino Acid Sequence; Base Sequence; Binding Sites; Crystallography, X-Ray; DNA; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Models, Molecular; Nuclear Proteins; Nucleic Acid Conformation; Protein Binding; Protein Domains; Repressor Proteins; Sequence Homology, Amino Acid | 2021 |
Complete loss of H3K9 methylation dissolves mouse heterochromatin organization.
Topics: Animals; Chromatin Immunoprecipitation Sequencing; Chromatography, Liquid; CRISPR-Cas Systems; Demethylation; Epigenesis, Genetic; Fibroblasts; Gene Deletion; Heterochromatin; Histone-Lysine N-Methyltransferase; Histones; In Situ Hybridization, Fluorescence; Lysine; Mass Spectrometry; Methylation; Mice; Microscopy, Electron, Transmission; Mutation; Protein Processing, Post-Translational; Repetitive Sequences, Nucleic Acid; Retroelements; RNA-Seq; Signal Transduction | 2021 |
M33 condenses chromatin through nuclear body formation and methylation of both histone H3 lysine 9 and lysine 27.
Topics: Cells, Cultured; Chromatin; Chromobox Protein Homolog 5; HEK293 Cells; Histones; Humans; Lysine; Methylation; Nuclear Proteins; Polycomb Repressive Complex 1 | 2021 |
The H3.3K27M oncohistone antagonizes reprogramming in Drosophila.
Topics: Animals; Animals, Genetically Modified; Cell Proliferation; Chromatin; Drosophila melanogaster; Drosophila Proteins; Eye; Gene Expression Regulation, Developmental; Gene Expression Regulation, Neoplastic; Histones; Larva; Lysine; Methylation; Microtubule-Associated Proteins; Mutation; Nuclear Proteins; Polycomb Repressive Complex 2 | 2021 |
Histone mimics: more tales to read.
Topics: Animals; Chromatin; Chromatin Assembly and Disassembly; DNA; Histones; Humans; Lysine; Methylation; Models, Biological; Protein Processing, Post-Translational | 2021 |
SMYD3 promotes hepatocellular carcinoma progression by methylating S1PR1 promoters.
Topics: Apoptosis; Base Sequence; Carcinoma, Hepatocellular; Cell Cycle; Cell Line, Tumor; Cell Movement; Cell Proliferation; Disease Progression; Gene Expression Regulation, Neoplastic; HEK293 Cells; Histone-Lysine N-Methyltransferase; Histones; Humans; Liver Neoplasms; Lysine; Methylation; Neoplasm Invasiveness; Promoter Regions, Genetic; RNA, Messenger; Signal Transduction; Sphingosine-1-Phosphate Receptors; Tumor Stem Cell Assay | 2021 |
Chromatin remodeler ARID1A binds IRF3 to selectively induce antiviral interferon production in macrophages.
Topics: Animals; Antiviral Agents; Chromatin; Chromatin Assembly and Disassembly; DNA-Binding Proteins; HEK293 Cells; Histone-Lysine N-Methyltransferase; Histones; Humans; Immunity, Innate; Interferon Regulatory Factor-3; Interferons; Lysine; Macrophages; Methylation; Mice; Promoter Regions, Genetic; Protein Binding; RAW 264.7 Cells; Transcription Factors; Vesiculovirus | 2021 |
Preparation of the ubiquitination-triggered active form of SETDB1 in Escherichia coli for biochemical and structural analyses.
Topics: Cell Line; Escherichia coli; Gene Silencing; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Protein Binding; Recombinant Proteins; Ubiquitination | 2021 |
FANCI plays an essential role in spermatogenesis and regulates meiotic histone methylation.
Topics: Animals; Apoptosis; Cell Differentiation; Epigenesis, Genetic; Fanconi Anemia; Gene Deletion; Histones; Infertility, Male; Lysine; Male; Meiosis; Methylation; Mice; Organ Specificity; Prophase; Recombination, Genetic; RNA, Messenger; Sex Chromosomes; Spermatogenesis; Spermatogonia; Spermatozoa; Testis | 2021 |
Alcohol-abuse drug disulfiram targets pediatric glioma via MLL degradation.
Topics: Alcoholism; Auranofin; Cell Line, Tumor; Cell Proliferation; Child; Disulfiram; Down-Regulation; Drug Repositioning; Drug Synergism; Gene Expression Regulation, Neoplastic; Glioma; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Myeloid-Lymphoid Leukemia Protein; Neoplasm Grading; Protein Processing, Post-Translational; Proteolysis; Transcription, Genetic | 2021 |
Histone demethylase KDM4A plays an oncogenic role in nasopharyngeal carcinoma by promoting cell migration and invasion.
Topics: Adult; Aged; Animals; Apoptosis; Carcinogenesis; Cell Line, Tumor; Cell Movement; Cell Proliferation; Female; Gene Expression Regulation, Neoplastic; Gene Silencing; Histones; Humans; Hypoxia-Inducible Factor 1, alpha Subunit; Jumonji Domain-Containing Histone Demethylases; Lysine; Male; Methylation; Mice, Nude; Middle Aged; Nasopharyngeal Carcinoma; Neoplasm Invasiveness; Signal Transduction; TOR Serine-Threonine Kinases; Transcription Factors; Up-Regulation; Young Adult | 2021 |
A Peptidomimetic Ligand Targeting the Chromodomain of MPP8 Reveals HRP2's Association with the HUSH Complex.
Topics: Cell Cycle Proteins; Fluorescence Resonance Energy Transfer; Histones; Hydrophobic and Hydrophilic Interactions; Intercellular Signaling Peptides and Proteins; Ligands; Lysine; Mass Spectrometry; Methylation; Models, Molecular; Peptidomimetics; Phosphoproteins; Protein Binding; Protein Domains; Protein Processing, Post-Translational; Proteomics; Structure-Activity Relationship | 2021 |
Histone H4 lysine 20 mono-methylation directly facilitates chromatin openness and promotes transcription of housekeeping genes.
Topics: Amino Acid Sequence; Animals; Cell Cycle; Cell Line; Chromatin; Genes, Essential; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Magnetic Resonance Spectroscopy; Methylation; Mice; Models, Biological; Nucleosomes; Protein Conformation; Transcription, Genetic | 2021 |
Glucose and TNF enhance expression of TNF and IL1B, and histone H3 acetylation and K4/K36 methylation, in juvenile macrophage cells.
Topics: Acetylation; Cell Line; Endothelial Cells; Gene Expression Regulation; Glucose; Histones; Humans; Interleukin-1beta; Lysine; Macrophages; Methylation; Protein Processing, Post-Translational; Tumor Necrosis Factor-alpha | 2020 |
Malat-1-PRC2-EZH1 interaction supports adaptive oxidative stress dependent epigenome remodeling in skeletal myotubes.
Topics: Animals; Cell Line; Ectoderm; Embryo, Mammalian; Epigenome; Gene Expression Regulation; Gene Silencing; Histones; Lysine; Methylation; Mice; Models, Biological; Muscle Fibers, Skeletal; Muscular Atrophy; Oxidative Stress; Phenotype; Polycomb Repressive Complex 2; Protein Binding; RNA, Long Noncoding; Transcription, Genetic | 2021 |
Histone modification of pain-related gene expression in spinal cord neurons under a persistent postsurgical pain-like state by electrocautery.
Topics: Animals; Annexins; Benzazepines; Cornified Envelope Proline-Rich Proteins; Disease Models, Animal; Electrocoagulation; Female; Foot Injuries; Gene Expression Regulation; Gene Knock-In Techniques; Genes, fos; Genes, Reporter; Histone Code; Histones; Hyperalgesia; Jumonji Domain-Containing Histone Demethylases; Lysine; Male; Methylation; Mice; Mice, Inbred C57BL; Nerve Tissue Proteins; Neuralgia; Neurons; Pain, Postoperative; Pyrimidines; RNA, Messenger; Spinal Cord; Tamoxifen | 2021 |
CPLM 4.0: an updated database with rich annotations for protein lysine modifications.
Topics: Acetylation; Animals; Bacteria; Biotinylation; Databases, Protein; Humans; Hydroxylation; Internet; Lysine; Methylation; Models, Molecular; Molecular Sequence Annotation; Mutation; Phosphorylation; Plants; Protein Binding; Protein Conformation; Protein Interaction Mapping; Protein Processing, Post-Translational; Proteins; RNA, Messenger; Software; Ubiquitination | 2022 |
Enhancer-associated H3K4 methylation safeguards in vitro germline competence.
Topics: Animals; Cell Differentiation; Chromatin; Embryo, Mammalian; Enhancer Elements, Genetic; Gene Expression Regulation; Germ Cells; Germ Layers; Histones; Lysine; Male; Methylation; Mice; Mice, Transgenic; Mouse Embryonic Stem Cells; Mutation; Otx Transcription Factors; RNA-Seq; Single-Cell Analysis; Transcription Initiation Site; Transcription, Genetic | 2021 |
Searching for methyllysine-binding aromatic cages.
Topics: Algorithms; Cytosol; Databases, Protein; Epigenesis, Genetic; Histones; Humans; Lysine; Methylation; Models, Molecular; Protein Binding; Protein Domains; Protein Processing, Post-Translational | 2021 |
Low-temperature plasma promotes growth of Haematococcus pluvialis and accumulation of astaxanthin by regulating histone H3 lysine 4 tri-methylation.
Topics: Histones; Lysine; Methylation; Temperature; Xanthophylls | 2022 |
ELK4-mediated lncRNA SNHG22 promotes gastric cancer progression through interacting with EZH2 and regulating miR-200c-3p/Notch1 axis.
Topics: Animals; Base Sequence; Binding Sites; Cell Line, Tumor; Cell Proliferation; Disease Progression; Enhancer of Zeste Homolog 2 Protein; ets-Domain Protein Elk-4; Female; Gene Expression Regulation, Neoplastic; Gene Silencing; Genes, Tumor Suppressor; Histones; Humans; Lysine; Methylation; Mice, Inbred BALB C; Mice, Nude; MicroRNAs; Neoplasm Invasiveness; Promoter Regions, Genetic; Protein Binding; Receptor, Notch1; RNA, Long Noncoding; Stomach Neoplasms; Up-Regulation | 2021 |
TDG is a pig-specific epigenetic regulator with insensitivity to H3K9 and H3K27 demethylation in nuclear transfer embryos.
Topics: Animals; Blastocyst; Demethylation; DNA Methylation; Embryo, Mammalian; Epigenesis, Genetic; Gene Expression Profiling; Gene Expression Regulation; Histone Demethylases; Histones; Indoles; Lysine; Methylation; Nuclear Transfer Techniques; Pyridones; Swine; Thymine DNA Glycosylase | 2021 |
Binding Methylarginines and Methyllysines as Free Amino Acids: A Comparative Study of Multiple Host Classes.
Topics: Amino Acids; Arginine; Lysine; Methylation; Protein Binding | 2022 |
Flagellin lysine methyltransferase FliB catalyzes a [4Fe-4S] mediated methyl transfer reaction.
Topics: Bacterial Proteins; Flagellin; Iron-Sulfur Proteins; Lysine; Methylation; Methyltransferases; S-Adenosylmethionine; Salmonella typhi | 2021 |
Mapping protein carboxymethylation sites provides insights into their role in proteostasis and cell proliferation.
Topics: Aging; Animals; Cell Line; Cell Proliferation; Endothelial Cells; Glycosylation; Glyoxal; Humans; Lysine; Methylation; Mice; Mice, Inbred C57BL; Microtubules; Primary Cell Culture; Protein Processing, Post-Translational; Proteins; Proteomics; Proteostasis; Tubulin | 2021 |
The Retinoblastoma Tumor Suppressor Is Required for the NUP98-HOXA9-Induced Aberrant Nuclear Envelope Phenotype.
Topics: Animals; DNA-Binding Proteins; Embryo, Mammalian; Epigenesis, Genetic; Fibroblasts; Genes, Tumor Suppressor; HCT116 Cells; Histones; Homeodomain Proteins; Humans; Lamin Type A; Lysine; Membrane Proteins; Methylation; Mice; Nuclear Pore Complex Proteins; Phenotype; Polycomb-Group Proteins; Retinoblastoma Protein | 2021 |
Global Reprogramming of Apoptosis-Related Genes during Brain Development.
Topics: Animals; Apoptosis; Apoptosis Regulatory Proteins; Brain; Caspases; Gene Expression Regulation, Developmental; Histone Code; Histones; Lysine; Methylation; Mice; Protein Processing, Post-Translational; Signal Transduction; Time Factors | 2021 |
Loss of Polycomb Repressive Complex 2 Function Alters Digestive Organ Homeostasis and Neuronal Differentiation in Zebrafish.
Topics: Animals; Animals, Genetically Modified; Behavior, Animal; Cell Differentiation; Digestive System; Gene Expression Regulation, Developmental; Histones; Homeostasis; Larva; Liver; Lysine; Methylation; Motor Activity; Mutation; Neurons; Organ Specificity; Polycomb Repressive Complex 2; Protein Processing, Post-Translational; RNA, Messenger; Transcription Activator-Like Effector Nucleases; Zebrafish; Zebrafish Proteins | 2021 |
Ezh2 promotes TRβ lysine methylation-mediated degradation in hepatocellular carcinoma.
Topics: Carcinoma, Hepatocellular; Enhancer of Zeste Homolog 2 Protein; Glucose; Humans; Liver Neoplasms; Lysine; Methylation; Protein Processing, Post-Translational; Thyroid Hormone Receptors beta | 2022 |
Development of an experiment-split method for benchmarking the generalization of a PTM site predictor: Lysine methylome as an example.
Topics: Benchmarking; Computational Biology; Deep Learning; Epigenome; Humans; Lysine; Methylation; Models, Genetic; Protein Processing, Post-Translational; Proteome | 2021 |
Changes in Epigenetic Patterns Related to DNA Replication in
Topics: 5-Methylcytosine; Acetylation; Cadmium; Cell Cycle; Chromatin; DNA Replication; DNA, Plant; Epigenesis, Genetic; Histones; Lysine; Meristem; Methylation; Phosphorylation; Stress, Physiological; Vicia faba | 2021 |
Histone H3K27 demethylase, Utx, regulates osteoblast-to-osteocyte differentiation.
Topics: Animals; Base Sequence; Bone Diseases, Metabolic; Cancellous Bone; Cell Count; Cell Differentiation; Down-Regulation; Epigenome; Genetic Loci; Histone Demethylases; Histones; Lysine; Methylation; Mice, Inbred C57BL; Mice, Knockout; Osteoblasts; Osteocytes; Phenotype; Protein Processing, Post-Translational; Transcriptome | 2022 |
TdIF1-LSD1 Axis Regulates Epithelial-Mesenchymal Transition and Metastasis via Histone Demethylation of E-Cadherin Promoter in Lung Cancer.
Topics: Animals; Cadherins; Carcinogenesis; Cell Line, Tumor; Cell Movement; Demethylation; DNA-Binding Proteins; Down-Regulation; Epithelial-Mesenchymal Transition; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Histone Demethylases; Histones; Lung Neoplasms; Lysine; Methylation; Mice, Inbred BALB C; Mice, Nude; Neoplasm Invasiveness; Neoplasm Metastasis; Promoter Regions, Genetic; Protein Binding; Transcription Factors | 2021 |
Multi-omic profiling of histone variant H3.3 lysine 27 methylation reveals a distinct role from canonical H3 in stem cell differentiation.
Topics: Animals; Cell Differentiation; Histones; Lysine; Methylation; Mice; Protein Processing, Post-Translational; Transcription Factors | 2022 |
Structural basis for the recognition of methylated histone H3 by the Arabidopsis LHP1 chromodomain.
Topics: Animals; Arabidopsis; Arabidopsis Proteins; Chromosomal Proteins, Non-Histone; Histones; Lysine; Methylation; Peptides; Transcription Factors | 2022 |
DOT1L activity in leukemia cells requires interaction with ubiquitylated H2B that promotes productive nucleosome binding.
Topics: Cell Line, Tumor; Cell Proliferation; Gene Rearrangement; Histone-Lysine N-Methyltransferase; Histones; Humans; Leukemia; Lysine; Male; Methylation; Models, Molecular; Myeloid-Lymphoid Leukemia Protein; Nucleosomes; Protein Binding; Ubiquitin; Ubiquitination | 2022 |
Histone marks regulate the epithelial-to-mesenchymal transition via alternative splicing.
Topics: Acetylation; Alternative Splicing; Base Sequence; Catenins; Cell Line; Chromatin; Delta Catenin; Epithelial-Mesenchymal Transition; Exons; Female; Histone Code; Histones; Humans; Lysine; Methylation; Receptor, Fibroblast Growth Factor, Type 2; RNA Polymerase II; RNA Precursors; Time Factors | 2022 |
SMYD5 is a histone H3-specific methyltransferase mediating mono-methylation of histone H3 lysine 36 and 37.
Topics: Animals; Gene Deletion; Histidine; Histones; Humans; Lysine; Methylation; Methyltransferases; Mice, Knockout; Protein Processing, Post-Translational | 2022 |
Histone H3 Lysine 4 and 27 Trimethylation Landscape of Human Alzheimer's Disease.
Topics: Alzheimer Disease; Epigenesis, Genetic; Female; Histones; Humans; Lysine; Male; Methylation; Neurodegenerative Diseases; Promoter Regions, Genetic | 2022 |
Methylation at a conserved lysine residue modulates tau assembly and cellular functions.
Topics: Animals; Lysine; Methylation; Mice; Neurons; Phosphorylation; Protein Processing, Post-Translational; tau Proteins | 2022 |
The histone H3.1 variant regulates TONSOKU-mediated DNA repair during replication.
Topics: Arabidopsis; Arabidopsis Proteins; DNA Breaks, Double-Stranded; DNA Polymerase theta; DNA Repair; DNA Replication; DNA-Directed DNA Polymerase; DNA, Plant; Genome, Plant; Genomic Instability; Histones; Lysine; Methylation; Methyltransferases; Mutation; Protein Interaction Domains and Motifs | 2022 |
Evaluation of Jumonji C lysine demethylase substrate preference to guide identification of
Topics: Histones; Jumonji Domain-Containing Histone Demethylases; Lysine; Methylation | 2022 |
H3K27me3 conditions chemotolerance in triple-negative breast cancer.
Topics: Drug Resistance, Neoplasm; Histones; Humans; Lysine; Methylation; Neoplasm Recurrence, Local; Triple Negative Breast Neoplasms | 2022 |
RBBP4 dysfunction reshapes the genomic landscape of H3K27 methylation and acetylation and disrupts gene expression.
Topics: Acetylation; Animals; Gene Expression; Genomics; Histones; Lysine; Methylation; Mice; Polycomb Repressive Complex 2; Retinoblastoma-Binding Protein 4 | 2022 |
Computational Study of Methionine Methylation Process Catalyzed by SETD3.
Topics: Actins; Catalysis; Histidine; Histone Methyltransferases; Lysine; Methionine; Methylation; Methyltransferases; Peptides; Racemethionine | 2022 |
EGLN1 prolyl hydroxylation of hypoxia-induced transcription factor HIF1α is repressed by SET7-catalyzed lysine methylation.
Topics: Animals; Catalysis; Histone-Lysine N-Methyltransferase; Humans; Hydroxylation; Hypoxia; Hypoxia-Inducible Factor 1, alpha Subunit; Hypoxia-Inducible Factor-Proline Dioxygenases; Lysine; Methylation; Oxygen; Protein Processing, Post-Translational | 2022 |
Structural basis of nucleosomal H4K20 methylation by methyltransferase SET8.
Topics: DNA Replication; Histones; Lysine; Methylation; Nucleosomes | 2022 |
Polycomb-mediated genome architecture enables long-range spreading of H3K27 methylation.
Topics: Animals; Chromatin Immunoprecipitation; Chromosomes; Embryo, Mammalian; Enhancer of Zeste Homolog 2 Protein; Gene Expression Regulation, Developmental; Gene Silencing; Histones; Humans; Induced Pluripotent Stem Cells; Lysine; Methylation; Mice; Nucleic Acid Conformation; Polycomb Repressive Complex 2 | 2022 |
Exercise-induced histone H3 trimethylation at lysine 27 facilitates the adaptation of skeletal muscle to exercise in mice.
Topics: Animals; Histone Code; Histones; Lysine; Methylation; Mice; Muscle, Skeletal; RNA Polymerase II | 2022 |
Histone gene editing probes functions of H3K27 modifications in mammals.
Topics: Animals; Gene Editing; Histones; Lysine; Mammals; Methylation | 2022 |
Not all Is SET for Methylation: Evolution of Eukaryotic Protein Methyltransferases.
Topics: Animals; Arginine; Eukaryota; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Methyltransferases; Protein Methyltransferases; Protein Processing, Post-Translational | 2022 |
Specificity Analysis of Protein Methyltransferases and Discovery of Novel Substrates Using SPOT Peptide Arrays.
Topics: Amino Acid Sequence; Lysine; Methylation; Methyltransferases; Peptides; Protein Methyltransferases; Substrate Specificity | 2022 |
Epigenetics of the frozen brain: roles for lysine methylation in hypometabolism.
Topics: Animals; Brain; Epigenesis, Genetic; Freezing; Histones; Lysine; Methylation; Ranidae | 2022 |
Interpretable machine learning identification of arginine methylation sites.
Topics: Algorithms; Arginine; Computational Biology; Lysine; Machine Learning; Methylation; Proteins | 2022 |
KDM4C Contributes to Trophoblast-like Stem Cell Conversion from Porcine-Induced Pluripotent Stem Cells (piPSCs) via Regulating CDX2.
Topics: Animals; Induced Pluripotent Stem Cells; Lysine; Methylation; Pluripotent Stem Cells; Swine; Trophoblasts | 2022 |
Lysine 27 dimethylation of Drosophila linker histone dH1 contributes to heterochromatin organization independently of H3K9 methylation.
Topics: Animals; Chromatin; DNA Transposable Elements; Drosophila; Drosophila melanogaster; Drosophila Proteins; Epigenesis, Genetic; Heterochromatin; Histones; Lysine; Methylation; Protein Processing, Post-Translational | 2022 |
Dissecting the Kinetic Mechanism of Human Lysine Methyltransferase 2D and Its Interactions with the WRAD2 Complex.
Topics: Histone-Lysine N-Methyltransferase; Histones; Humans; Intracellular Signaling Peptides and Proteins; Kinetics; Lysine; Methylation; Myeloid-Lymphoid Leukemia Protein | 2022 |
HIV-1 Preintegration Complex Preferentially Integrates the Viral DNA into Nucleosomes Containing Trimethylated Histone 3-Lysine 36 Modification and Flanking Linker DNA.
Topics: Chromatin; Chromosomes, Human; DNA, Viral; Histone Code; Histones; HIV Infections; HIV Integrase; HIV-1; Humans; Lysine; Methylation; Nucleosomes; Virus Integration | 2022 |
Putative SET-domain methyltransferases in
Topics: Child, Preschool; Cryptosporidiosis; Cryptosporidium; Cryptosporidium parvum; Epigenesis, Genetic; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation | 2022 |
Methylation patterns of Lys9 and Lys27 on histone H3 correlate with patient outcome and tumor progression in lung cancer.
Topics: Adenocarcinoma of Lung; DNA Methylation; Histones; Humans; Lung Neoplasms; Lysine; Methylation; Prognosis; Retrospective Studies | 2022 |
Roles of C/EBP-homologous protein and histone H3 lysine 4 methylation in arsenic-induced mitochondrial apoptosis in hepatocytes.
Topics: Apoptosis; Arsenic; bcl-2-Associated X Protein; Hepatocytes; Histone Demethylases; Histones; Lysine; Methylation; RNA, Small Interfering | 2022 |
H3K9me1/2 methylation limits the lifespan of
Topics: Animals; Caenorhabditis elegans; Caenorhabditis elegans Proteins; Forkhead Transcription Factors; Histone Methyltransferases; Histones; Insulin; Insulin-Like Growth Factor I; Longevity; Lysine; Mammals; Methylation; Methyltransferases; Receptor, Insulin; RNA, Messenger | 2022 |
Unraveling the Role of the Tyrosine Tetrad from the Binding Site of the Epigenetic Writer MLL3 in the Catalytic Mechanism and Methylation Multiplicity.
Topics: Alanine; Binding Sites; Epigenesis, Genetic; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Phenylalanine; Tyrosine; Water | 2022 |
Multifactorial feature extraction and site prognosis model for protein methylation data.
Topics: Algorithms; Arginine; Computational Biology; Lysine; Methylation; Prognosis; Protein Processing, Post-Translational; Proteomics | 2023 |
The assembly of mammalian SWI/SNF chromatin remodeling complexes is regulated by lysine-methylation dependent proteolysis.
Topics: Animals; Chromatin; Chromatin Assembly and Disassembly; Histone Demethylases; Lysine; Mammals; Methylation; Mice; Proteolysis | 2022 |
High-affinity chromodomains engineered for improved detection of histone methylation and enhanced CRISPR-based gene repression.
Topics: Chromatin; Histones; Humans; Lysine; Methylation; Protein Processing, Post-Translational | 2022 |
Poly ADP-ribosylation of SET8 leads to aberrant H4K20 methylation in mammalian nuclear genome.
Topics: ADP-Ribosylation; Animals; Histone-Lysine N-Methyltransferase; Histones; Lysine; Mammals; Methylation; Protein Processing, Post-Translational | 2022 |
Proteome-wide identification of non-histone lysine methylation in tomato during fruit ripening.
Topics: Chromatography, Liquid; Fruit; Gene Expression Regulation, Plant; Histones; Lysine; Methylation; Plant Proteins; Proteome; Solanum lycopersicum; Tandem Mass Spectrometry | 2022 |
Structural and Energetic Origin of Different Product Specificities and Activities for SETD3 and Its Mutants on the Methylation of the β-Actin H73K Peptide: Insights from a QM/MM Study.
Topics: Actins; Histone-Lysine N-Methyltransferase; Lysine; Methylation; Molecular Dynamics Simulation; Peptides | 2023 |
A complete methyl-lysine binding aromatic cage constructed by two domains of PHF2.
Topics: Histones; Homeodomain Proteins; Lysine; Methylation; Peptides; Protein Binding; Protein Domains | 2023 |
Set7 methyltransferase roles in myocardial protection from chronic stressors.
Topics: Chromatin; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation | 2023 |
Global lysine methylome profiling using systematically characterized affinity reagents.
Topics: Antibodies; Epigenome; Humans; Lysine; Methylation; Peptides; Proteome | 2023 |
JMJD8 Functions as a Novel AKT1 Lysine Demethylase.
Topics: Jumonji Domain-Containing Histone Demethylases; Lysine; Methylation; NF-kappa B; Signal Transduction | 2022 |
Structural remodeling of AAA+ ATPase p97 by adaptor protein ASPL facilitates posttranslational methylation by METTL21D.
Topics: Adaptor Proteins, Signal Transducing; Adenosine Triphosphatases; Animals; ATPases Associated with Diverse Cellular Activities; Humans; Lysine; Methylation; Methyltransferases; Protein Binding; Protein Processing, Post-Translational; Transcription Factors; Valosin Containing Protein | 2023 |
Lysine 27 of histone H3.3 is a fine modulator of developmental gene expression and stands as an epigenetic checkpoint for lignin biosynthesis in Arabidopsis.
Topics: Arabidopsis; Epigenesis, Genetic; Genes, Developmental; Histones; Lignin; Lysine; Methylation | 2023 |
Menin "reads" H3K79me2 mark in a nucleosomal context.
Topics: Animals; Chromatin; Cryoelectron Microscopy; Epigenesis, Genetic; Histones; Humans; Lysine; Methylation; Molecular Probes; Nucleosomes; Protein Processing, Post-Translational; Proteomics; Proto-Oncogene Proteins | 2023 |
Methylation of CENP-A/Cse4 on arginine 143 and lysine 131 regulates kinetochore stability in yeast.
Topics: Arginine; Centromere Protein A; Chromosomal Proteins, Non-Histone; DNA-Binding Proteins; Histones; Kinetochores; Lysine; Methylation; Nuclear Proteins; Nucleosomes; Protein Processing, Post-Translational; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins | 2023 |
Selenium nanoparticles modulate histone methylation via lysine methyltransferase activity and S-adenosylhomocysteine depletion.
Topics: Antioxidants; Chitosan; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; S-Adenosylhomocysteine; Selenium | 2023 |
Histone methylation readers MRG1/MRG2 interact with the transcription factor TCP14 to positively modulate cytokinin sensitivity in Arabidopsis.
Topics: Arabidopsis; Arabidopsis Proteins; Chromosomal Proteins, Non-Histone; Cytokinins; Gene Expression Regulation, Plant; Histones; Lysine; Methylation; Transcription Factors | 2023 |
Methylation of histone H3 lysine 4 is required for maintenance of beta cell function in adult mice.
Topics: Animals; Diabetes Mellitus, Type 2; Histone-Lysine N-Methyltransferase; Histones; Insulins; Lysine; Methylation; Mice | 2023 |
Identification of nonhistone substrates of the lysine methyltransferase PRDM9.
Topics: Apoptosis Regulatory Proteins; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; Nuclear Proteins; Protein Processing, Post-Translational; Substrate Specificity | 2023 |
Antibody toolkit to investigate eEF1A methylation dynamics in mRNA translation elongation.
Topics: Antibodies; Lysine; Methylation; Peptide Chain Elongation, Translational; Peptide Elongation Factor 1 | 2023 |
Nanofluidic Device for Detection of Lysine Methylpeptides and Sensing of Lysine Methylation.
Topics: Lysine; Methylation; Methyltransferases; Protein Processing, Post-Translational; Proteins | 2023 |
The T1150A cancer mutant of the protein lysine dimethyltransferase NSD2 can introduce H3K36 trimethylation.
Topics: Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Mutation; Neoplasms | 2023 |
Methylation of lysine 36 on histone H3 is required to control transposon activities in somatic cells.
Topics: Animals; DNA Transposable Elements; DNA-Binding Proteins; Drosophila melanogaster; Drosophila Proteins; Histone-Lysine N-Methyltransferase; Histones; Lysine; Methylation; RNA, Small Interfering; Transcription Factors | 2023 |
Epigenetic plasticity safeguards heterochromatin configuration in mammals.
Topics: Animals; Epigenesis, Genetic; Heterochromatin; Histone Methyltransferases; Histones; Lysine; Mammals; Methylation | 2023 |
The FAM86 domain of FAM86A confers substrate specificity to promote EEF2-Lys525 methylation.
Topics: Crystallography, X-Ray; Humans; Lysine; Methylation; Methyltransferases; Models, Molecular; Peptide Elongation Factor 2; Point Mutation; Protein Domains; Protein Structure, Tertiary; S-Adenosylmethionine; Substrate Specificity | 2023 |
ASH2L, a COMPASS core subunit, is involved in the cell invasion and migration of triple-negative breast cancer cells through the epigenetic control of histone H3 lysine 4 methylation.
Topics: DNA-Binding Proteins; Epigenesis, Genetic; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Nuclear Proteins; Transcription Factors; Triple Negative Breast Neoplasms | 2023 |
SETD7 promotes metastasis of triple-negative breast cancer by YY1 lysine methylation.
Topics: Cell Proliferation; Female; Histone-Lysine N-Methyltransferase; Humans; Lysine; Methylation; Protein Processing, Post-Translational; Triple Negative Breast Neoplasms; YY1 Transcription Factor | 2023 |
Epigenetic Histone Methylation of PPARγ and CPT1A Signaling Contributes to Betahistine Preventing Olanzapine-Induced Dyslipidemia.
Topics: Animals; Benzodiazepines; Betahistine; Carnitine O-Palmitoyltransferase; Dyslipidemias; Epigenesis, Genetic; Histones; Lysine; Methylation; Olanzapine; PPAR gamma; Rats | 2023 |
Lysine 68 Methylation-Dependent SOX9 Stability Control Modulates Chondrogenic Differentiation in Dental Pulp Stem Cells.
Topics: Cell Differentiation; Cells, Cultured; Chondrogenesis; Dental Pulp; Lysine; Methylation; Stem Cells | 2023 |
Comparative analysis of the occupancy of Histone H3 Lysine 4 methylation in the cells treated with TGFβ and Interferonγ.
Topics: Epigenesis, Genetic; Histones; Humans; Interferon-gamma; Lysine; Methylation; Protein Processing, Post-Translational; Transforming Growth Factor beta | 2023 |
Combined low levels of H4K16ac and H4K20me3 predicts poor prognosis in breast cancer.
Topics: Breast Neoplasms; Female; Histones; Humans; Lysine; Methylation; Prognosis | 2023 |
Lysine methylation promotes NFAT5 activation and determines temozolomide efficacy in glioblastoma.
Topics: ErbB Receptors; Glioblastoma; Humans; Lysine; Methylation; NFATC Transcription Factors; Temozolomide; TNF Receptor-Associated Factor 6; Transcription Factors | 2023 |
Limited choice of natural amino acids as mimetics restricts design of protein lysine methylation studies.
Topics: Amines; Amino Acids; Biomimetics; Lysine; Methylation | 2023 |
Lysine Methyltransferase SMYD1 Regulates Myogenesis via skNAC Methylation.
Topics: DNA-Binding Proteins; Lysine; Methylation; Methyltransferases; Muscle Development; Myocardium | 2023 |
Diverse modes of H3K36me3-guided nucleosomal deacetylation by Rpd3S.
Topics: Acetylation; Cryoelectron Microscopy; DNA, Fungal; Epigenesis, Genetic; Histones; Lysine; Methylation; Multiprotein Complexes; Nucleosomes; Saccharomyces cerevisiae; Saccharomyces cerevisiae Proteins | 2023 |
Proteome-Wide Identification of Non-histone Lysine Methylation during Grape Berry Ripening.
Topics: Gene Expression Profiling; Histones; Lysine; Methylation; Peptides; Protein Interaction Maps; Proteome; Vitis | 2023 |
Advances in direct detection of lysine methylation and acetylation by nuclear magnetic resonance using
Topics: Acetylation; Lysine; Magnetic Resonance Spectroscopy; Methylation; Protein Processing, Post-Translational | 2023 |
LncRNA H19-EZH2 interaction promotes liver fibrosis via reprogramming H3K27me3 profiles.
Topics: Animals; Epigenesis, Genetic; Hepatic Stellate Cells; Histones; Liver; Liver Cirrhosis; Lysine; Methylation; Mice; RNA, Long Noncoding | 2023 |
Lysine methylation of PPP1CA by the methyltransferase SUV39H2 disrupts TFEB-dependent autophagy and promotes intervertebral disc degeneration.
Topics: Autophagy; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Histone-Lysine N-Methyltransferase; Humans; Intervertebral Disc Degeneration; Lysine; Methylation; Protein Phosphatase 1; Protein Processing, Post-Translational; Proteomics | 2023 |
BRWD3 promotes KDM5 degradation to maintain H3K4 methylation levels.
Topics: Animals; Chromatin; Drosophila; Histone Code; Lysine; Methylation; Protein Processing, Post-Translational | 2023 |
Acetyl-methyllysine marks chromatin at active transcription start sites.
Topics: Acetylation; Animals; Chromatin; Histone Deacetylases; Histones; Humans; Lysine; Methylation; Peptides; Protein Processing, Post-Translational; Transcription Initiation Site | 2023 |
Rare de novo gain-of-function missense variants in DOT1L are associated with developmental delay and congenital anomalies.
Topics: Congenital Abnormalities; Developmental Disabilities; Drosophila; Drosophila Proteins; Gain of Function Mutation; Histone-Lysine N-Methyltransferase; Histones; Humans; Lysine; Methylation; Methyltransferases; Neoplasms | 2023 |
SET7/9-mediated methylation affects oncogenic functions of histone demethylase JMJD2A.
Topics: Carcinogenesis; Cell Transformation, Neoplastic; Histone Demethylases; Humans; Jumonji Domain-Containing Histone Demethylases; Lysine; Male; Matrix Metalloproteinase 1; Methylation; Prostatic Neoplasms | 2023 |
TNRC18 engages H3K9me3 to mediate silencing of endogenous retrotransposons.
Topics: Animals; Animals, Newborn; Cell Line; Chromatin; Co-Repressor Proteins; Endogenous Retroviruses; Epigenesis, Genetic; Gene Expression Profiling; Gene Silencing; Genome; Histone Deacetylases; Histones; Humans; Intracellular Signaling Peptides and Proteins; Lysine; Methylation; Mice; Protein Domains; Retroelements; Terminal Repeat Sequences | 2023 |
Asymmetric distribution of parental H3K9me3 in S phase silences L1 elements.
Topics: DNA Replication; Gene Silencing; Histones; Humans; Long Interspersed Nucleotide Elements; Lysine; Methylation; S Phase | 2023 |