lysine has been researched along with deoxyhypusine in 34 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (20.59) | 18.7374 |
| 1990's | 12 (35.29) | 18.2507 |
| 2000's | 4 (11.76) | 29.6817 |
| 2010's | 10 (29.41) | 24.3611 |
| 2020's | 1 (2.94) | 2.80 |
| Authors | Studies |
|---|---|
| Folk, JE; Hershey, JW; Park, MH; Smit-McBride, Z; Wolff, EC | 1 |
| Folk, JE; Park, MH; Wolff, EC | 1 |
| Abbruzzese, A; Beninati, S; Folk, JE | 1 |
| Chen, KY; Dou, QP | 1 |
| Chen, KY; Davis, RH; Seyfzadeh, M; Yang, YC | 1 |
| Abbruzzese, A; Folk, JE; Park, MH | 1 |
| Park, MH | 2 |
| Park, MH; Wolff, EC | 1 |
| Gallop, PM; Paz, MA; Torrelio, BM | 1 |
| Folk, JE; Liberato, DJ; Park, MH; Yergey, AL | 1 |
| Cooper, HL; Folk, JE; Park, MH | 1 |
| Joe, YA; Park, MH | 1 |
| Bevec, D; Csonga, R; Hauber, J; Jaksche, H; Kappel, B; Klier, H; Steinkasserer, A | 1 |
| Beppu, T; Samejima, K; Shirahata, A | 1 |
| Joe, YA; Lee, YB; Park, MH; Wolff, EC | 1 |
| Davies, DR; Liao, DI; Park, MH; Wolff, EC | 1 |
| Bergeron, RJ; McCosar, BH; Müller, R; Smith, RE; Weimar, WR; Yao, H; Zimmerman, CO | 2 |
| Clement, PM; Hanauske-Abel, HM; Kleinman, HK; Park, MH; Wolff, EC | 1 |
| Folk, JE; Park, JH; Park, MH; Wolff, EC | 1 |
| Gowda, PG; Huang, GH; Huang, JK; Tsai, S; Walzer, AM; Wen, L | 1 |
| Atemnkeng, V; Blavid, R; Frommholz, D; Kaiser, AE; Kusch, P; Marciniak, J; Marcus, K; Scheer, H; Tu, JM; Zhao, KH | 1 |
| Deck, JA; Folk, JE; Fraser, CS; Lee, SB; Park, JH; Park, MH; Pegg, AE; Sokabe, M | 1 |
| Dias, CA; Fraser, CS; Lee, SB; Park, JH; Park, MH; Sokabe, M; Valentini, SR | 1 |
| Lee, SB; Park, MH; Wolff, EC | 1 |
| Park, JH; Park, MH; Wolff, EC | 1 |
| Agostinelli, E; Kaiser, A; Khomutov, AR; Simonian, A | 1 |
| Imam, S; Jaume, JC; Mirmira, RG | 1 |
| Alhonen, L; Hyvönen, MT; Keinänen, TA; Khomutov, AR; Khomutov, M; Kochetkov, SN; Petit, M; Vepsäläinen, J; Weisell, J | 1 |
| Böttger, LH; Han, Z; Hauber, J; Hilgenfeld, R; Klinke, S; Sakai, N; Trautwein, AX | 1 |
| Grishin, NV; Kinch, L; Leija, C; Li, Q; Nguyen, S; Phillips, MA; Regmi, S | 1 |
| Carter, PJ; Deshayes, K; Dixit, VM; He, M; Song, A; Zhai, Q | 1 |
| Fu, Q; Lin, H; Su, D; Wang, M; Zhang, S; Zhang, Y; Zhu, J | 1 |
34 other study(ies) available for lysine and deoxyhypusine
| Article | Year |
|---|---|
Comparison of the activities of variant forms of eIF-4D. The requirement for hypusine or deoxyhypusine.
Topics: Animals; Cadaverine; Cells, Cultured; Chromatography, Ion Exchange; Cricetinae; Eflornithine; Escherichia coli; Eukaryotic Translation Initiation Factor 5A; Humans; Lysine; Molecular Structure; Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; Periodic Acid; Puromycin; RNA-Binding Proteins; Spermidine; Substrate Specificity | 1991 |
Cleavage of spermidine as the first step in deoxyhypusine synthesis. The role of NAD.
Topics: Animals; Chromatography, Gel; Chromatography, Ion Exchange; Eukaryotic Translation Initiation Factor 5A; Kinetics; Lysine; Male; NAD; Oxidation-Reduction; Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; Protein Precursors; Rats; RNA-Binding Proteins; Spermidine; Testis | 1990 |
High-performance liquid chromatographic method for determination of hypusine and deoxyhypusine.
Topics: Animals; Cattle; Cells, Cultured; Chromatography, High Pressure Liquid; Chromatography, Ion Exchange; Lysine; Male; Microchemistry; Rats; Rats, Inbred Strains; Regression Analysis; Reproducibility of Results; Spectrometry, Fluorescence | 1990 |
Characterization and reconstitution of a cell free system for NAD(+)-dependent deoxyhypusine formation on the 18 kDa eIF-4D precursor.
Topics: Animals; Cell Line; Cell-Free System; Eukaryotic Translation Initiation Factor 5A; Lysine; Mice; Molecular Weight; NAD; Neuroblastoma; Peptide Initiation Factors; Protein Precursors; RNA-Binding Proteins | 1990 |
Deoxyhypusine/hypusine formation on a 21,000-dalton cellular protein in a Neurospora crassa mutant in vivo and in vitro.
Topics: Electrophoresis, Polyacrylamide Gel; Fungal Proteins; Isoelectric Focusing; Lysine; Mutation; Neurospora; Neurospora crassa; Polyamines | 1990 |
Indirect assays for deoxyhypusine hydroxylase using dual-label ratio changes and oxidative release of radioactivity.
Topics: Carbon Radioisotopes; Isotope Labeling; Lysine; Mixed Function Oxygenases; Oxidation-Reduction; Time Factors; Tritium | 1986 |
Regulation of biosynthesis of hypusine in Chinese hamster ovary cells. Evidence for eIF-4D precursor polypeptides.
Topics: Animals; Cell Line; Cricetinae; Cricetulus; Cycloheximide; Eflornithine; Female; Fibroblasts; Gene Expression Regulation; Lysine; Ovary; Protein Biosynthesis; Protein Processing, Post-Translational; Spermidine | 1987 |
The identification of an eukaryotic initiation factor 4D precursor in spermidine-depleted Chinese hamster ovary cells.
Topics: Animals; Cell Line; Cricetinae; Cricetulus; Eukaryotic Translation Initiation Factor 5A; Female; Isoelectric Point; Lysine; Ovary; Peptide Initiation Factors; Peptide Mapping; Protein Precursors; Protein Processing, Post-Translational; RNA-Binding Proteins; Spermidine | 1988 |
Cell-free synthesis of deoxyhypusine. Separation of protein substrate and enzyme and identification of 1,3-diaminopropane as a product of spermidine cleavage.
Topics: Animals; Cell Line; Cell-Free System; Chromatography, Ion Exchange; Cricetinae; Diamines; Eflornithine; Eukaryotic Translation Initiation Factor 5A; Lysine; NAD; Peptide Initiation Factors; RNA-Binding Proteins; Spermidine | 1988 |
Hydralazine inhibition of the post-translational hydroxylation of deoxyhypusine, a polyamine-derived amino acid.
Topics: Animals; Cell Line; Cricetinae; Cricetulus; DNA Replication; Female; Hydralazine; Hydroxylation; Lysine; Ovary; Protein Biosynthesis; Putrescine | 1984 |
The biosynthesis of hypusine (N epsilon-(4-amino-2-hydroxybutyl)lysine). Alignment of the butylamine segment and source of the secondary amino nitrogen.
Topics: Animals; Butylamines; Cell Line; Chromatography, High Pressure Liquid; Cricetinae; Cricetulus; Female; Isotope Labeling; Lysine; Mass Spectrometry; Putrescine; Spermidine | 1984 |
The biosynthesis of protein-bound hypusine (N epsilon -(4-amino-2-hydroxybutyl)lysine). Lysine as the amino acid precursor and the intermediate role of deoxyhypusine (N epsilon -(4-aminobutyl)lysine).
Topics: Animals; Cell Line; Cricetinae; Cricetulus; Female; Kinetics; Lysine; Ovary; Putrescine; Radioisotope Dilution Technique; Spermidine; Tritium | 1982 |
Structural features of the eIF-5A precursor required for posttranslational synthesis of deoxyhypusine.
Topics: Amino Acid Sequence; Base Sequence; Conserved Sequence; DNA Mutational Analysis; Eukaryotic Translation Initiation Factor 5A; Humans; Lysine; Molecular Sequence Data; Oligopeptides; Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; Protein Precursors; Protein Processing, Post-Translational; RNA-Binding Proteins; Sequence Deletion; Substrate Specificity | 1994 |
Molecular characterization of a cDNA encoding functional human deoxyhypusine synthase and chromosomal mapping of the corresponding gene locus.
Topics: Amino Acid Sequence; Base Sequence; Chromosome Mapping; Chromosomes, Human, Pair 19; DNA, Complementary; Escherichia coli; Gene Expression; HeLa Cells; Humans; Lysine; Molecular Sequence Data; Molecular Weight; Oxidoreductases Acting on CH-NH Group Donors; Recombinant Proteins; Sequence Analysis, DNA | 1996 |
Determination of covalently bound hypusine and deoxyhypusine to protein using submilligram of protein samples by HPLC.
Topics: Animals; Carcinoma, Hepatocellular; Cell Line; Chromatography, High Pressure Liquid; Lysine; Protein Binding; Rats; Reference Standards; Tumor Cells, Cultured | 1996 |
Enzyme-substrate intermediate at a specific lysine residue is required for deoxyhypusine synthesis. The role of Lys329 in human deoxyhypusine synthase.
Topics: Biopolymers; Humans; Lysine; Mutagenesis, Site-Directed; Oxidoreductases Acting on CH-NH Group Donors; Spermidine; Substrate Specificity | 1997 |
Crystal structure of the NAD complex of human deoxyhypusine synthase: an enzyme with a ball-and-chain mechanism for blocking the active site.
Topics: Binding Sites; Crystallography, X-Ray; Humans; Hydrogen Bonding; Lysine; Models, Molecular; NAD; Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; Protein Conformation; Protein Processing, Post-Translational; Protein Structure, Secondary; Recombinant Proteins; Spermidine | 1998 |
Synthesis of reagents for the construction of hypusine and deoxyhypusine peptides and their application as peptidic antigens.
Topics: Animals; Antibodies, Monoclonal; CHO Cells; Cricetinae; Cross Reactions; Enzyme-Linked Immunosorbent Assay; Eukaryotic Translation Initiation Factor 5A; Haptens; Hemocyanins; Humans; Lysine; Maleimides; Mice; Mice, Inbred BALB C; Oligopeptides; Ovalbumin; Peptide Initiation Factors; RNA-Binding Proteins; Stereoisomerism | 1998 |
Effect of polyamine analogues on hypusine content in JURKAT T-cells.
Topics: Adenosylmethionine Decarboxylase; Animals; Antineoplastic Agents; Biological Transport; Cell Division; Chromatography, High Pressure Liquid; Dansyl Compounds; Enzyme Inhibitors; Humans; Jurkat Cells; Leukemia L1210; Lysine; Ornithine Decarboxylase Inhibitors; Spermidine; Spermine; Tumor Cells, Cultured | 1998 |
The antifungal drug ciclopirox inhibits deoxyhypusine and proline hydroxylation, endothelial cell growth and angiogenesis in vitro.
Topics: Antifungal Agents; Cell Cycle; Cell Division; Cells, Cultured; Ciclopirox; DNA; Endothelium, Vascular; Humans; Hydroxylation; Lysine; Models, Biological; Neovascularization, Physiologic; Proline; Pyridones | 2002 |
Reversal of the deoxyhypusine synthesis reaction. Generation of spermidine or homospermidine from deoxyhypusine by deoxyhypusine synthase.
Topics: Eukaryotic Translation Initiation Factor 5A; Humans; Hydrogen-Ion Concentration; Kinetics; Lysine; Models, Chemical; NAD; Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; Putrescine; RNA-Binding Proteins; Spermidine; Time Factors; Trichloroacetic Acid | 2003 |
Higher activity of recombinant bovine deoxyhypusine synthase vs. human deoxyhypusine synthase.
Topics: Amino Acid Sequence; Animals; Cattle; Cloning, Molecular; Escherichia coli; Eukaryotic Translation Initiation Factor 5A; Genetic Vectors; Humans; Lysine; Molecular Sequence Data; Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; Protein Processing, Post-Translational; Recombinant Proteins; RNA-Binding Proteins; Sequence Alignment | 2004 |
Completing the hypusine pathway in Plasmodium.
Topics: Amino Acid Sequence; Animals; Blotting, Western; Gas Chromatography-Mass Spectrometry; Lysine; Mixed Function Oxygenases; Molecular Sequence Data; Molecular Structure; Plasmodium; Polymerase Chain Reaction; Protozoan Proteins; Sequence Homology, Amino Acid | 2009 |
Inactivation of eukaryotic initiation factor 5A (eIF5A) by specific acetylation of its hypusine residue by spermidine/spermine acetyltransferase 1 (SSAT1).
Topics: Acetylation; Acetyltransferases; Animals; Cattle; Cell Line, Tumor; Eukaryotic Translation Initiation Factor 5A; Humans; Lysine; Peptide Initiation Factors; Protein Binding; RNA-Binding Proteins | 2011 |
Production of active recombinant eIF5A: reconstitution in E.coli of eukaryotic hypusine modification of eIF5A by its coexpression with modifying enzymes.
Topics: Animals; Cattle; Cloning, Molecular; Escherichia coli; Eukaryotic Translation Initiation Factor 5A; Gene Expression; Genetic Vectors; Humans; Lysine; Mixed Function Oxygenases; Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; Recombinant Proteins; RNA-Binding Proteins; Temperature; Time Factors | 2011 |
Assay of deoxyhypusine synthase activity.
Topics: Biosynthetic Pathways; Cell Extracts; Chemical Precipitation; Chromatography, Ion Exchange; Electrophoresis, Polyacrylamide Gel; Enzyme Assays; Eukaryotic Translation Initiation Factor 5A; HeLa Cells; Humans; Lysine; Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; Radioactivity; RNA-Binding Proteins; Trichloroacetic Acid | 2011 |
Assay of deoxyhypusine hydroxylase activity.
Topics: Biosynthetic Pathways; Cells, Cultured; Chromatography, Ion Exchange; Enzyme Assays; Eukaryotic Translation Initiation Factor 5A; Humans; Lysine; Mixed Function Oxygenases; Oxidation-Reduction; Peptide Initiation Factors; Periodic Acid; Protein Binding; RNA-Binding Proteins; Substrate Specificity | 2011 |
A rapid and robust assay for the determination of the amino acid hypusine as a possible biomarker for a high-throughput screening of antimalarials and for the diagnosis and therapy of different diseases.
Topics: Animals; Antimalarials; Catalytic Domain; Chromatography, High Pressure Liquid; Eukaryotic Initiation Factor-5; Humans; Lysine; Malaria; Mice; Mixed Function Oxygenases; Oxidoreductases Acting on CH-NH Group Donors; Plasmodium; Protein Hydrolysates | 2012 |
Eukaryotic translation initiation factor 5A inhibition alters physiopathology and immune responses in a "humanized" transgenic mouse model of type 1 diabetes.
Topics: Animals; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 1; Enzyme Inhibitors; Eukaryotic Translation Initiation Factor 5A; Female; Glutamate Decarboxylase; Guanine; HLA-DQ alpha-Chains; HLA-DQ beta-Chains; Humans; Immunity, Innate; Lysine; Mice; Mice, Transgenic; Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; RNA-Binding Proteins | 2014 |
Enantiomers of 3-methylspermidine selectively modulate deoxyhypusine synthesis and reveal important determinants for spermidine transport.
Topics: Biological Transport; Cell Line, Tumor; Eflornithine; Eukaryotic Translation Initiation Factor 5A; Gene Expression; Humans; Lysine; Male; Ornithine Decarboxylase Inhibitors; Oxidoreductases Acting on CH-NH Group Donors; Peptide Initiation Factors; Protein Processing, Post-Translational; RNA-Binding Proteins; Spermidine; Stereoisomerism; Substrate Specificity | 2015 |
Crystal Structure of the Peroxo-diiron(III) Intermediate of Deoxyhypusine Hydroxylase, an Oxygenase Involved in Hypusination.
Topics: Catalytic Domain; Crystallography, X-Ray; Enzyme Stability; Eukaryotic Translation Initiation Factor 5A; Glycerol; Humans; Lysine; Mixed Function Oxygenases; Models, Molecular; Molecular Docking Simulation; Peptide Initiation Factors; RNA-Binding Proteins; Substrate Specificity | 2015 |
Deoxyhypusine Modification of Eukaryotic Translation Initiation Factor 5A (eIF5A) Is Essential for Trypanosoma brucei Growth and for Expression of Polyprolyl-containing Proteins.
Topics: Amino Acid Sequence; Animals; Escherichia coli; Eukaryotic Translation Initiation Factor 5A; Flagella; Gene Knockdown Techniques; Humans; Lysine; Microfilament Proteins; Molecular Sequence Data; Peptide Initiation Factors; Peptides; Protein Processing, Post-Translational; Proteome; Protozoan Proteins; Recombinant Proteins; RNA-Binding Proteins; RNA, Messenger; RNA, Protozoan; RNA, Small Interfering; Sequence Alignment; Sequence Homology, Amino Acid; Trypanosoma brucei brucei | 2015 |
Structural Analysis and Optimization of Context-Independent Anti-Hypusine Antibodies.
Topics: Amino Acid Sequence; Animals; Antibodies, Monoclonal; Antibody Affinity; Crystallography, X-Ray; Eukaryotic Translation Initiation Factor 5A; Humans; Lysine; Models, Molecular; Molecular Sequence Data; Peptide Initiation Factors; Protein Processing, Post-Translational; Rabbits; RNA-Binding Proteins | 2016 |
Oxygen level regulates N-terminal translation elongation of selected proteins through deoxyhypusine hydroxylation.
Topics: Hydroxylation; Lysine; Oxygen; Peptide Initiation Factors; Peptides; Protein Biosynthesis; Saccharomyces cerevisiae | 2022 |