lyngbyaloside-b and 3-hydroxybutanal

lyngbyaloside-b has been researched along with 3-hydroxybutanal* in 1 studies

Other Studies

1 other study(ies) available for lyngbyaloside-b and 3-hydroxybutanal

Article	Year
Total synthesis, stereochemical reassignment, and biological evaluation of (-)-lyngbyaloside B. Angewandte Chemie (International ed. in English), 2015, Jan-12, Volume: 54, Issue:3 (-)-Lyngbyaloside B is a 14-membered macrolide glycoside isolated from the marine cyanobacterium Lyngbya sp. as a cytotoxic substance by Moore and co-workers. The first total synthesis of (-)-lyngbyaloside B and the reassignment of its stereostructure is described. The synthesis features an Abiko-Masamune aldol reaction, a vinylogous Mukaiyama aldol reaction, and a macrocyclization involving an acyl ketene intermediate for the construction of the macrocyclic backbone, which contains an acylated tertiary alcohol. The antiproliferative activity of selected compounds against a small panel of human cancer cell lines is also reported. Topics: Aldehydes; Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Cyanobacteria; Cyclization; HL-60 Cells; Humans; Macrolides; Stereoisomerism	2015

Article

Year

Total synthesis, stereochemical reassignment, and biological evaluation of (-)-lyngbyaloside B.

Angewandte Chemie (International ed. in English), 2015, Jan-12, Volume: 54, Issue:3

(-)-Lyngbyaloside B is a 14-membered macrolide glycoside isolated from the marine cyanobacterium Lyngbya sp. as a cytotoxic substance by Moore and co-workers. The first total synthesis of (-)-lyngbyaloside B and the reassignment of its stereostructure is described. The synthesis features an Abiko-Masamune aldol reaction, a vinylogous Mukaiyama aldol reaction, and a macrocyclization involving an acyl ketene intermediate for the construction of the macrocyclic backbone, which contains an acylated tertiary alcohol. The antiproliferative activity of selected compounds against a small panel of human cancer cell lines is also reported.

Topics: Aldehydes; Antineoplastic Agents; Cell Line, Tumor; Cell Survival; Cyanobacteria; Cyclization; HL-60 Cells; Humans; Macrolides; Stereoisomerism

2015