lyngbyabellin-a and jasplakinolide

lyngbyabellin-a has been researched along with jasplakinolide* in 1 studies

Other Studies

1 other study(ies) available for lyngbyabellin-a and jasplakinolide

Article	Year
Structure and absolute stereochemistry of hectochlorin, a potent stimulator of actin assembly. Journal of natural products, 2002, Volume: 65, Issue:6 Hectochlorin (1) was isolated from marine isolates of Lyngbya majuscula collected from Hector Bay, Jamaica, and Boca del Drago Beach, Bocas del Toro, Panama. The planar structure was deduced by one- and two-dimensional NMR spectroscopy. X-ray crystallography was used to determine the absolute stereochemistry of hectochlorin as 2S,3S,14S,22S. Hectochlorin is equipotent to jasplakinolide (5) in its ability to promote actin polymerization, but unlike jasplakinolide, is unable to displace a fluorescent phalloidin analogue from polymerized actin. In addition, hectochlorin shows both a unique profile of cytotoxicity by the COMPARE algorithm and potent inhibitory activity toward the fungus Candida albicans. Structurally, hectochlorin resembles dolabellin and the recently reported lyngbyabellin class of compounds. Topics: Actins; Anti-Bacterial Agents; Antifungal Agents; Candida albicans; Crystallography, X-Ray; Cyanobacteria; Depsipeptides; Fluorescein-5-isothiocyanate; Inhibitory Concentration 50; Jamaica; Lactones; Lyngbya Toxins; Molecular Conformation; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Panama; Peptides, Cyclic; Thiazoles	2002

Article

Year

Structure and absolute stereochemistry of hectochlorin, a potent stimulator of actin assembly.

Journal of natural products, 2002, Volume: 65, Issue:6

Hectochlorin (1) was isolated from marine isolates of Lyngbya majuscula collected from Hector Bay, Jamaica, and Boca del Drago Beach, Bocas del Toro, Panama. The planar structure was deduced by one- and two-dimensional NMR spectroscopy. X-ray crystallography was used to determine the absolute stereochemistry of hectochlorin as 2S,3S,14S,22S. Hectochlorin is equipotent to jasplakinolide (5) in its ability to promote actin polymerization, but unlike jasplakinolide, is unable to displace a fluorescent phalloidin analogue from polymerized actin. In addition, hectochlorin shows both a unique profile of cytotoxicity by the COMPARE algorithm and potent inhibitory activity toward the fungus Candida albicans. Structurally, hectochlorin resembles dolabellin and the recently reported lyngbyabellin class of compounds.

Topics: Actins; Anti-Bacterial Agents; Antifungal Agents; Candida albicans; Crystallography, X-Ray; Cyanobacteria; Depsipeptides; Fluorescein-5-isothiocyanate; Inhibitory Concentration 50; Jamaica; Lactones; Lyngbya Toxins; Molecular Conformation; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Panama; Peptides, Cyclic; Thiazoles

2002