ly2409021 and cyclopropanol

ly2409021 has been researched along with cyclopropanol* in 1 studies

Other Studies

1 other study(ies) available for ly2409021 and cyclopropanol

Article	Year
Efficient Synthesis of β-CF3/SCF3-Substituted Carbonyls via Copper-Catalyzed Electrophilic Ring-Opening Cross-Coupling of Cyclopropanols. Organic letters, 2015, May-01, Volume: 17, Issue:9 The first copper-catalyzed ring-opening electrophilic trifluoromethylation and trifluoromethylthiolation of cyclopropanols to form Csp3-CF3 and Csp3-SCF3 bonds have been realized. These transformations are efficient for the synthesis of β-CF3- and β-SCF3-substituted carbonyl compounds that are otherwise challenging to access. The reaction conditions are mild and tolerate a wide range of functional groups. Application to a concise synthesis of LY2409021, a glucagon receptor antagonist that is used in clinical trials for type 2 diabetes mellitus, is reported as well. Topics: Alkenes; Biphenyl Compounds; Catalysis; Copper; Diabetes Mellitus, Type 2; Ethers, Cyclic; Hydrocarbons, Fluorinated; Iodides; Molecular Structure; Receptors, Glucagon; Stereoisomerism	2015

Article

Year

Efficient Synthesis of β-CF3/SCF3-Substituted Carbonyls via Copper-Catalyzed Electrophilic Ring-Opening Cross-Coupling of Cyclopropanols.

Organic letters, 2015, May-01, Volume: 17, Issue:9

The first copper-catalyzed ring-opening electrophilic trifluoromethylation and trifluoromethylthiolation of cyclopropanols to form Csp3-CF3 and Csp3-SCF3 bonds have been realized. These transformations are efficient for the synthesis of β-CF3- and β-SCF3-substituted carbonyl compounds that are otherwise challenging to access. The reaction conditions are mild and tolerate a wide range of functional groups. Application to a concise synthesis of LY2409021, a glucagon receptor antagonist that is used in clinical trials for type 2 diabetes mellitus, is reported as well.

Topics: Alkenes; Biphenyl Compounds; Catalysis; Copper; Diabetes Mellitus, Type 2; Ethers, Cyclic; Hydrocarbons, Fluorinated; Iodides; Molecular Structure; Receptors, Glucagon; Stereoisomerism

2015