Compounds > ly 97241
Page last updated: 2024-09-05

ly 97241 and terfenadine

ly 97241 has been researched along with terfenadine in 4 studies

Compound Research Comparison

Studies
(ly 97241)		Trials
(ly 97241)		Recent Studies (post-2010)
(ly 97241)		Studies
(terfenadine)		Trials
(terfenadine)		Recent Studies (post-2010) (terfenadine)
11011,751568346

Protein Interaction Comparison

ProteinTaxonomyly 97241 (IC50)terfenadine (IC50)
Voltage-dependent L-type calcium channel subunit alpha-1FHomo sapiens (human)0.93
5-hydroxytryptamine receptor 4Cavia porcellus (domestic guinea pig)1.231
Epidermal growth factor receptorHomo sapiens (human)3.566
Tyrosine-protein kinase FynHomo sapiens (human)6.123
ATP-dependent translocase ABCB1Mus musculus (house mouse)2
Aldo-keto reductase family 1 member B1Rattus norvegicus (Norway rat)1.928
ATP-dependent translocase ABCB1Homo sapiens (human)1.8167
Cytochrome P450 3A4Homo sapiens (human)0.32
Muscarinic acetylcholine receptor M1Homo sapiens (human)2.9
D(2) dopamine receptorHomo sapiens (human)6.167
Dipeptidyl peptidase 4Rattus norvegicus (Norway rat)0.35
Alpha-1B adrenergic receptorRattus norvegicus (Norway rat)2.34
Alpha-2C adrenergic receptorHomo sapiens (human)3.748
DRattus norvegicus (Norway rat)0.1288
Alpha-2B adrenergic receptorRattus norvegicus (Norway rat)0.1288
Substance-K receptorHomo sapiens (human)2.677
D(1A) dopamine receptorHomo sapiens (human)2.673
Alpha-2C adrenergic receptorRattus norvegicus (Norway rat)0.1288
Alpha-2A adrenergic receptorRattus norvegicus (Norway rat)0.1288
Alpha-1D adrenergic receptorRattus norvegicus (Norway rat)2.34
Sodium-dependent noradrenaline transporter Homo sapiens (human)1.928
Sodium-dependent dopamine transporterRattus norvegicus (Norway rat)0.1288
Alpha-1D adrenergic receptorHomo sapiens (human)2.34
5-hydroxytryptamine receptor 2AHomo sapiens (human)0.255
5-hydroxytryptamine receptor 2CHomo sapiens (human)1.231
Histamine H1 receptorCavia porcellus (domestic guinea pig)0.094
Alpha-1A adrenergic receptorHomo sapiens (human)2.34
Histamine H1 receptorHomo sapiens (human)0.0115
Alpha-1B adrenergic receptorHomo sapiens (human)2.34
D(3) dopamine receptorHomo sapiens (human)1.503
5-hydroxytryptamine receptor 2BHomo sapiens (human)0.048
Alpha-1A adrenergic receptorRattus norvegicus (Norway rat)2.34
5-hydroxytryptamine receptor 6Homo sapiens (human)1.306
Cytochrome P450 2J2Homo sapiens (human)8.1
C-C chemokine receptor type 5Homo sapiens (human)1.103
Voltage-dependent L-type calcium channel subunit alpha-1D Homo sapiens (human)0.93
Sodium-dependent dopamine transporter Homo sapiens (human)0.255
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)0.2233
Voltage-dependent L-type calcium channel subunit alpha-1SHomo sapiens (human)0.93
Voltage-dependent L-type calcium channel subunit alpha-1CHomo sapiens (human)1.125
Sodium channel protein type 5 subunit alphaHomo sapiens (human)0.971

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's3 (75.00)29.6817
2010's1 (25.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bechstedt, S; Gessner, G; Heinemann, SH; Schönherr, R; Zacharias, M1
Du, LP; Li, MY; Tsai, KC; Xia, L; You, QD1
Sen, S; Sinha, N1
Finlayson, K; January, CT; Kelly, JS; Sharkey, J; Turnbull, L1

Other Studies

4 other study(ies) available for ly 97241 and terfenadine

ArticleYear
Molecular determinants for high-affinity block of human EAG potassium channels by antiarrhythmic agents.
    Molecular pharmacology, 2004, Volume: 65, Issue:5

    Topics: Amino Acid Sequence; Animals; Cells, Cultured; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Humans; Models, Molecular; Molecular Sequence Data; Mutagenesis, Site-Directed; Oocytes; Potassium Channels; Potassium Channels, Voltage-Gated; Quaternary Ammonium Compounds; Sequence Homology, Amino Acid; Xenopus laevis

2004
The pharmacophore hypotheses of I(Kr) potassium channel blockers: novel class III antiarrhythmic agents.
    Bioorganic & medicinal chemistry letters, 2004, Sep-20, Volume: 14, Issue:18

    Topics: Anti-Arrhythmia Agents; Models, Biological; Models, Molecular; Potassium Channel Blockers; Potassium Channels; Quantitative Structure-Activity Relationship; Technology, Pharmaceutical

2004
Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model.
    European journal of medicinal chemistry, 2011, Volume: 46, Issue:2

    Topics: Computer Simulation; Ether-A-Go-Go Potassium Channels; Humans; Molecular Structure; Organic Chemicals; Quantitative Structure-Activity Relationship

2011
[3H]dofetilide binding to HERG transfected membranes: a potential high throughput preclinical screen.
    European journal of pharmacology, 2001, Oct-26, Volume: 430, Issue:1

    Topics: Anti-Arrhythmia Agents; Benzimidazoles; Binding, Competitive; Cation Transport Proteins; Cell Line; Cell Membrane; DNA-Binding Proteins; Drug Evaluation, Preclinical; Electrocardiography; ERG1 Potassium Channel; Ether-A-Go-Go Potassium Channels; Haloperidol; Humans; Patch-Clamp Techniques; Phenethylamines; Pimozide; Potassium Channel Blockers; Potassium Channels; Potassium Channels, Voltage-Gated; Quaternary Ammonium Compounds; Sulfanilamides; Sulfonamides; Terfenadine; Trans-Activators; Transcriptional Regulator ERG; Transfection; Tritium

2001