ly 353381 has been researched along with raloxifene hydrochloride in 23 studies
| Studies (ly 353381) | Trials (ly 353381) | Recent Studies (post-2010) (ly 353381) | Studies (raloxifene hydrochloride) | Trials (raloxifene hydrochloride) | Recent Studies (post-2010) (raloxifene hydrochloride) |
|---|---|---|---|---|---|
| 70 | 12 | 15 | 2,818 | 481 | 810 |
| Protein | Taxonomy | ly 353381 (IC50) | raloxifene hydrochloride (IC50) |
|---|---|---|---|
| Estrogen receptor | Homo sapiens (human) | 0.0053 | |
| Gastric inhibitory polypeptide receptor | Homo sapiens (human) | 0.0004 | |
| Estrogen receptor beta | Homo sapiens (human) | 0.1297 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (4.35) | 18.2507 |
| 2000's | 15 (65.22) | 29.6817 |
| 2010's | 7 (30.43) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Adrian, MD; Bryant, HU; Rowley, E; Sato, M; Turner, CH; Wang, T | 1 |
| Galid, A; Kubista, E; Seifert, M | 1 |
| Elit, L; Hirte, H | 1 |
| Gajdos, C; Jordan, VC | 1 |
| Bethea, CL; Michelson, D; Mirkes, SJ; Su, A | 1 |
| Chan, S | 1 |
| Cox, DA; Hurn, PD; Littleton-Kearney, MT; Ostrowski, NL; Rossberg, MI | 1 |
| Fried, A; Segev, E; Wientroub, S; Zeitlin, L | 1 |
| Sporn, MB | 1 |
| David, E; Fournier dit Chabert, J; Lemaire, M; Pellet-Rostaing, S; Perrin, J | 1 |
| Johansen, AM | 1 |
| Bolton, JL; Liu, H; Qin, Z; Thatcher, GR | 1 |
| Asghodom, RT; Bolton, JL; Frasor, J; Kastrati, I; Lantvit, DD; Overk, CR; Peng, KW; Qin, Z; Thatcher, GR | 1 |
| Bolton, JL; Dietz, BM; Dunlap, T; Kastrati, I; Lantvit, DD; Overk, CR; Qin, Z; Thatcher, GR; Yao, P; Yu, B | 1 |
| Bolton, JL; Edirisinghe, P; Qin, Z; Thatcher, GR; Wijewickrama, GT; Yu, B | 1 |
| Cox, DA; Downs, RW; Dowsett, SA; Ghosh, A; Harper, K; Moffett, AM | 1 |
| Lewiecki, EM | 1 |
| Alam, J; Cox, DA; Dowsett, SA; Kendler, DL; Palacios, S; Stock, J; Zanchetta, J | 1 |
| Arun, B; Brown, PH; Castiglione, M; Cuzick, J; DeCensi, A; Dunn, B; Forbes, JF; Glaus, A; Howell, A; Vogel, V; von Minckwitz, G; Zwierzina, H | 1 |
| Alam, J; Bhattoa, HP; Cox, DA; Dowsett, SA; Goldstein, SR; Muram, D; Neven, P; Sipos, A | 1 |
| Bolton, JL; Chandrasena, ER; Choi, J; Edirisinghe, PD; Hemachandra, LP; Kastrati, I; Thatcher, GR; Wang, YT | 1 |
| Cuzick, J; Sestak, I | 1 |
| Briarava, M; Mocellin, S; Nitti, D; Pilati, P | 1 |
9 review(s) available for ly 353381 and raloxifene hydrochloride
| Article | Year |
|---|---|
Current status and future innovations of hormonal agents, chemotherapy and investigational agents in endometrial cancer.
Topics: Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Endometrial Neoplasms; Female; Genes, Tumor Suppressor; Humans; Neoplasm Staging; Phosphoric Monoester Hydrolases; Piperidines; Progestins; PTEN Phosphohydrolase; Raloxifene Hydrochloride; Selective Estrogen Receptor Modulators; Survival Rate; Thiophenes; Tumor Suppressor Proteins | 2002 |
Selective estrogen receptor modulators as a new therapeutic drug group: concept to reality in a decade.
Topics: Anticarcinogenic Agents; Antineoplastic Agents, Phytogenic; Breast Neoplasms; Cinnamates; Drug Design; Forecasting; Humans; Molecular Biology; Piperidines; Pyrrolidines; Raloxifene Hydrochloride; Selective Estrogen Receptor Modulators; Stilbenes; Tamoxifen; Tetrahydronaphthalenes; Thiophenes; Toremifene; Treatment Outcome | 2002 |
A review of selective estrogen receptor modulators in the treatment of breast and endometrial cancer.
Topics: Antineoplastic Agents, Hormonal; Breast Neoplasms; Endometrial Neoplasms; Estradiol; Female; Fulvestrant; Humans; Piperidines; Raloxifene Hydrochloride; Selective Estrogen Receptor Modulators; Tamoxifen; Thiophenes | 2002 |
Selective estrogen receptor modulators: tissue actions and potential for CNS protection.
Topics: Animals; Breast Neoplasms; Cardiovascular System; Central Nervous System; Cognition; Estrogen Antagonists; Estrogen Receptor Modulators; Female; Hormone Replacement Therapy; Humans; Hypothalamo-Hypophyseal System; Male; Neuroprotective Agents; Osteoporosis, Postmenopausal; Piperidines; Raloxifene Hydrochloride; Receptors, Neurotransmitter; Structure-Activity Relationship; Tamoxifen; Thiophenes; Uterus | 2002 |
Arzoxifene: a promising new selective estrogen receptor modulator for clinical chemoprevention of breast cancer.
Topics: Anticarcinogenic Agents; Breast Neoplasms; Female; Humans; Molecular Structure; Neoplasm Staging; Piperidines; Raloxifene Hydrochloride; Selective Estrogen Receptor Modulators; Structure-Activity Relationship; Thiophenes | 2004 |
Breast cancer chemoprevention: a review of selective estrogen receptor modulators.
Topics: Breast Neoplasms; Female; Humans; Piperidines; Raloxifene Hydrochloride; Risk Assessment; Selective Estrogen Receptor Modulators; Tamoxifen; Thiophenes | 2005 |
Current and emerging pharmacologic therapies for the management of postmenopausal osteoporosis.
Topics: Aged; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Bone Density Conservation Agents; Denosumab; Drug Therapy, Combination; Female; Humans; Indoles; Middle Aged; Osteoporosis, Postmenopausal; Parathyroid Hormone; Piperidines; Postmenopause; Pyrrolidines; Raloxifene Hydrochloride; RANK Ligand; Selective Estrogen Receptor Modulators; Tamoxifen; Tetrahydronaphthalenes; Thiophenes; Vitamin D; Women's Health | 2009 |
Preventive therapy for breast cancer: a consensus statement.
Topics: Anastrozole; Androstadienes; Anti-Inflammatory Agents, Non-Steroidal; Anticarcinogenic Agents; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Consensus Development Conferences as Topic; Diphosphonates; Estrogen Receptor Modulators; Expert Testimony; Female; Fenretinide; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Metformin; Nitriles; Norpregnenes; Piperidines; Premenopause; Pyrrolidines; Raloxifene Hydrochloride; Retinoids; Selective Estrogen Receptor Modulators; Tamoxifen; Tetrahydronaphthalenes; Thiophenes; Triazoles | 2011 |
Breast Cancer Chemoprevention: A Network Meta-Analysis of Randomized Controlled Trials.
Topics: Adult; Aged; Anticarcinogenic Agents; Antineoplastic Agents, Hormonal; Aromatase Inhibitors; Breast Neoplasms; Female; Humans; Middle Aged; Norpregnenes; Piperidines; Postmenopause; Primary Prevention; Pyrrolidines; Raloxifene Hydrochloride; Randomized Controlled Trials as Topic; Risk Assessment; Selective Estrogen Receptor Modulators; Tamoxifen; Tetrahydronaphthalenes; Thiophenes | 2016 |
3 trial(s) available for ly 353381 and raloxifene hydrochloride
| Article | Year |
|---|---|
Effects of arzoxifene on bone, lipid markers, and safety parameters in postmenopausal women with low bone mass.
Topics: Aged; Biomarkers; Bone Density; Bone Density Conservation Agents; Bone Remodeling; Dose-Response Relationship, Drug; Double-Blind Method; Endometrium; Female; Humans; Lipids; Middle Aged; Osteoporosis, Postmenopausal; Piperidines; Raloxifene Hydrochloride; Selective Estrogen Receptor Modulators; Thiophenes; Vasomotor System | 2010 |
Arzoxifene versus raloxifene: effect on bone and safety parameters in postmenopausal women with osteoporosis.
Topics: Absorptiometry, Photon; Aged; Bone Density; Bone Density Conservation Agents; Bone Remodeling; Double-Blind Method; Female; Femur Neck; Hip Joint; Hot Flashes; Humans; Lumbar Vertebrae; Middle Aged; Osteoporosis, Postmenopausal; Piperidines; Raloxifene Hydrochloride; Thiophenes; Treatment Outcome | 2012 |
Gynecologic effects of arzoxifene in postmenopausal women with osteoporosis or low bone mass.
Topics: Aged; Aged, 80 and over; Endometrial Neoplasms; Endometrium; Female; Genital Diseases, Female; Humans; Middle Aged; Osteoporosis, Postmenopausal; Piperidines; Placebos; Polyps; Postmenopause; Raloxifene Hydrochloride; Selective Estrogen Receptor Modulators; Thiophenes; Uterine Hemorrhage; Vaginitis; Vulvitis | 2012 |
11 other study(ies) available for ly 353381 and raloxifene hydrochloride
| Article | Year |
|---|---|
LY353381.HCl: a novel raloxifene analog with improved SERM potency and efficacy in vivo.
Topics: Animals; Biomechanical Phenomena; Body Weight; Bone and Bones; Cholesterol; Estrogen Antagonists; Female; Organ Size; Ovariectomy; Piperidines; Raloxifene Hydrochloride; Rats; Rats, Sprague-Dawley; Receptors, Estrogen; Thiophenes; Uterus | 1998 |
The oestrogen receptor and its selective modulators in gynaecological oncology.
Topics: Antineoplastic Agents, Hormonal; Cinnamates; Estrogen Antagonists; Female; Genital Neoplasms, Female; Humans; Norpregnenes; Piperidines; Raloxifene Hydrochloride; Selective Estrogen Receptor Modulators; Stilbenes; Tamoxifen; Thiophenes; Toremifene | 2000 |
Effects of oral estrogen, raloxifene and arzoxifene on gene expression in serotonin neurons of macaques.
Topics: Animals; Carrier Proteins; Estradiol; Estrogen Antagonists; Estrogen Replacement Therapy; Female; Gene Expression; Macaca mulatta; Membrane Glycoproteins; Membrane Transport Proteins; Mesencephalon; Nerve Tissue Proteins; Piperidines; Raloxifene Hydrochloride; Receptors, Serotonin; Receptors, Serotonin, 5-HT1; RNA, Messenger; Selective Estrogen Receptor Modulators; Serotonin Plasma Membrane Transport Proteins; Thiophenes; Tryptophan Hydroxylase | 2002 |
Effects of long-term administration of N-3 polyunsaturated fatty acids (PUFA) and selective estrogen receptor modulator (SERM) derivatives in ovariectomized (OVX) mice.
Topics: Adipose Tissue; Animals; Body Weight; Bone Marrow Cells; Cholesterol; Fatty Acids, Omega-3; Fatty Acids, Unsaturated; Female; Fish Oils; Hypolipidemic Agents; Interleukin-1; Interleukin-10; Interleukin-6; Mice; Mice, Inbred BALB C; Ovariectomy; Ovary; Piperidines; Raloxifene Hydrochloride; Selective Estrogen Receptor Modulators; Skin; Spleen; Thiophenes; Triglycerides; Tumor Necrosis Factor-alpha | 2003 |
Efficient access to 2-aryl-3-substituted benzo[b]thiophenes.
Topics: Cyclization; Molecular Structure; Oxidation-Reduction; Piperidines; Raloxifene Hydrochloride; Selective Estrogen Receptor Modulators; Structure-Activity Relationship; Thiophenes | 2005 |
Uterine peroxidase-catalyzed formation of diquinone methides from the selective estrogen receptor modulators raloxifene and desmethylated arzoxifene.
Topics: Alkylation; Animals; Catalysis; Female; Glutathione; Horseradish Peroxidase; Indolequinones; Microsomes; Piperidines; Quinones; Raloxifene Hydrochloride; Rats; Selective Estrogen Receptor Modulators; Thiophenes; Uterus | 2007 |
Structure-activity relationships for a family of benzothiophene selective estrogen receptor modulators including raloxifene and arzoxifene.
Topics: Animals; Female; Lipids; Organ Size; Piperidines; Raloxifene Hydrochloride; Rats; Rats, Sprague-Dawley; Receptors, Estrogen; Selective Estrogen Receptor Modulators; Structure-Activity Relationship; Thiophenes; Uterus | 2007 |
Structural modulation of reactivity/activity in design of improved benzothiophene selective estrogen receptor modulators: induction of chemopreventive mechanisms.
Topics: Animals; Antioxidants; Breast Neoplasms; Carcinoma, Hepatocellular; Chemoprevention; Female; Humans; Liver; Liver Neoplasms; Luciferases; Mice; NAD(P)H Dehydrogenase (Quinone); Oxidation-Reduction; Peroxides; Piperidines; Raloxifene Hydrochloride; Rats; Rats, Sprague-Dawley; Receptors, Estrogen; Selective Estrogen Receptor Modulators; Thiophenes; Tumor Cells, Cultured | 2007 |
Comparative methods for analysis of protein covalent modification by electrophilic quinoids formed from xenobiotics.
Topics: Animals; Azides; Biotinylation; Cell Extracts; Cell Line, Tumor; Hepatocytes; Indicators and Reagents; Ligands; Mass Spectrometry; Oxidation-Reduction; Piperidines; Proteins; Quinones; Raloxifene Hydrochloride; Rats; Receptors, Estrogen; Selective Estrogen Receptor Modulators; Staining and Labeling; Thiophenes; Xenobiotics | 2009 |
Raloxifene and desmethylarzoxifene block estrogen-induced malignant transformation of human breast epithelial cells.
Topics: 8-Hydroxy-2'-Deoxyguanosine; Animals; Biomarkers; Breast; Catechols; Cell Line; Cell Transformation, Neoplastic; Cytochrome P-450 Enzyme System; Deoxyguanosine; DNA Adducts; Enzyme Induction; Epithelial Cells; Estrogens; Female; Histone Deacetylase Inhibitors; Horses; Humans; Oxidation-Reduction; Oxidative Stress; Piperidines; Raloxifene Hydrochloride; Selective Estrogen Receptor Modulators; Thiophenes | 2011 |
Preventive therapy for breast cancer.
Topics: Aromatase Inhibitors; Breast Neoplasms; Chemotherapy, Adjuvant; Endometrial Neoplasms; Female; Humans; Meta-Analysis as Topic; Middle Aged; Piperidines; Preventive Medicine; Pyrrolidines; Raloxifene Hydrochloride; Receptor, ErbB-2; Selective Estrogen Receptor Modulators; Tamoxifen; Tetrahydronaphthalenes; Thiophenes | 2012 |