ly-334370 has been researched along with naratriptan* in 1 studies
1 other study(ies) available for ly-334370 and naratriptan
Article | Year |
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5-HT1F receptor agonists inhibit neurogenic dural inflammation in guinea pigs.
The serotonin (5-HT) receptor subtype mediating inhibition of neurogenic dural inflammation in guinea pigs was investigated using a series of serotonin agonists with differing affinities for the 5-HT1B, 5-HT1D and 5-HT1F receptors. When agonist potencies for inhibiting neurogenic inflammation were compared with affinities for these receptor subtypes, a significant positive correlation was seen only with the 5-HT1F receptor. The potency of agonists in inhibiting adenylate cyclase in cells transfected with human 5-HT1F receptor was also highly correlated with their potency in the animal model of migraine. In situ hybridization demonstrated 5-HT1F receptor mRNA in guinea pig trigeminal ganglion neurons. These data suggest that the 5-HT1F receptor is a rational target for migraine therapeutics. Topics: Animals; Benzamides; Carbazoles; Disease Models, Animal; Guinea Pigs; In Situ Hybridization; Indoles; Inflammation; Male; Piperidines; Pyrazoles; Rabbits; Receptor, Serotonin, 5-HT1F; Receptors, Serotonin; RNA, Messenger; Serotonin Receptor Agonists; Trigeminal Ganglion; Tryptamines | 1997 |