ly 303511 has been researched along with 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one in 21 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (4.76) | 18.2507 |
| 2000's | 15 (71.43) | 29.6817 |
| 2010's | 5 (23.81) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Augustin, M; Davies, SP; Gao, Y; Harvey, KJ; Kovelman, R; Patel, UA; Woodward, A | 1 |
| Munoz, L | 1 |
| Badwey, JA; Brown, RF; Ding, J; Liu, R; Vlahos, CJ | 1 |
| El-Kholy, W; Fox, JM; Light, PE; Lin, JH; Macdonald, PE; Tsushima, RG; Wang, J; Wang, Q; Wheeler, MB | 1 |
| Estridge, TB; Matter, WF; McCall, E; McDowell, SA; Vlahos, CJ | 1 |
| Choi, EK; Kang, HC; Kang, IC; Kim, BG; Lee, HC; Ma, JS; Park, HJ | 1 |
| Pervaiz, S; Poh, TW | 1 |
| Choi, EK; Jang, HC; Kang, HC; Kang, IC; Kim, HJ; Kim, JH; Lee, HC; Lee, SH; Oh, WM; Paek, YW | 1 |
| Hamilton, T; Mandal, P | 1 |
| Sato, T; Wang, P; Wu, P; Yamagata, S; Yamagata, T; Zhang, J | 1 |
| Hirpara, JL; Huang, S; Pervaiz, S; Poh, TW | 1 |
| Cen, LP; Chiang, SW; Cui, Q; Fan, YM; Huang, Y; Lam, DS; Lin, D; Luo, JM; Pang, CP; van Rooijen, N; Zhang, XM | 1 |
| Collier, JJ; Eckert, DT; O'Doherty, RM; Scott, DK; Zhang, P | 1 |
| Chen, QM; Sheveleva, E; Sun, H; Xu, B | 1 |
| Li, J; Liu, P; Lu, H; Xu, B | 1 |
| Ashizawa, K; Katayama, S; Narumi, K; Omura, Y; Tatemoto, H; Tsuzuki, Y | 1 |
| Hughes, BA; Pattnaik, BR | 1 |
| Hoyer, PB; J Mark, C; Keating, AF; Sen, N; Sipes, IG | 1 |
| Beck, BH; Bodenstine, TM; Cook, LM; Diers, AR; Ismail, A; Landar, A; Vaidya, KS; Welch, DR | 1 |
| Kopantsev, EP; Korobko, EV; Korobko, IV; Shepelev, MV; Vinogradova, TV | 1 |
| Bantscheff, M; Chung, CW; Dittmann, A; Drewes, G; Fälth Savitski, M; Grandi, P; Hopf, C; Lindon, M; Neubauer, G; Prinjha, RK; Savitski, MM; Werner, T | 1 |
1 review(s) available for ly 303511 and 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one
| Article | Year |
|---|---|
Non-kinase targets of protein kinase inhibitors.
Topics: Animals; Drug Design; Drug Evaluation, Preclinical; Humans; Molecular Targeted Therapy; Protein Kinase Inhibitors; Protein Kinases | 2017 |
20 other study(ies) available for ly 303511 and 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one
| Article | Year |
|---|---|
A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery.
Topics: Aurora Kinases; Cluster Analysis; Drug Design; Drug Discovery; Drug Evaluation, Preclinical; ErbB Receptors; Humans; Intracellular Signaling Peptides and Proteins; MAP Kinase Kinase 4; p38 Mitogen-Activated Protein Kinases; Protein Kinase Inhibitors; Protein Kinases; Protein Serine-Threonine Kinases; Protein-Tyrosine Kinases; Receptors, Vascular Endothelial Growth Factor; Recombinant Proteins; Reproducibility of Results; Signal Transduction; Small Molecule Libraries; Structure-Activity Relationship; Syk Kinase | 2013 |
Antagonists of phosphatidylinositol 3-kinase block activation of several novel protein kinases in neutrophils.
Topics: Androstadienes; Animals; Chromones; Enzyme Activation; Enzyme Inhibitors; Guinea Pigs; In Vitro Techniques; Kinetics; Morpholines; N-Formylmethionine Leucyl-Phenylalanine; NADH, NADPH Oxidoreductases; NADPH Oxidases; Neutrophils; Phosphatidylinositol 3-Kinases; Phosphorylation; Phosphotransferases (Alcohol Group Acceptor); Piperazines; Protamine Kinase; Protein Denaturation; Protein Kinase Inhibitors; Protein Kinases; Superoxides; Tetradecanoylphorbol Acetate; Wortmannin | 1995 |
The phosphatidylinositol 3-kinase inhibitor LY294002 potently blocks K(V) currents via a direct mechanism.
Topics: Androstadienes; Animals; Cell Line; Cells, Cultured; Chromones; Dichlororibofuranosylbenzimidazole; Dose-Response Relationship, Drug; Enzyme Inhibitors; Glucose; Humans; Insulin; Insulin Secretion; Islets of Langerhans; Membrane Potentials; Morpholines; Patch-Clamp Techniques; Phosphoinositide-3 Kinase Inhibitors; Piperazines; Potassium Channels, Voltage-Gated; Rats; Signal Transduction; Transfection; Wortmannin | 2003 |
Phosphoinositide 3-kinase regulates excitation-contraction coupling in neonatal cardiomyocytes.
Topics: 3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; Animals; Animals, Newborn; Calcium; Calcium Channels, L-Type; Calcium-Transporting ATPases; Cells, Cultured; Chromones; Endoplasmic Reticulum; Enzyme Inhibitors; Heart Ventricles; Kinetics; Morpholines; Myocardial Contraction; Myocytes, Cardiac; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Piperazines; Platelet-Derived Growth Factor; Rats; Rats, Sprague-Dawley; Ryanodine Receptor Calcium Release Channel; Sarcoplasmic Reticulum; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Sodium-Calcium Exchanger; Ventricular Function | 2004 |
LY294002 inhibits monocyte chemoattractant protein-1 expression through a phosphatidylinositol 3-kinase-independent mechanism.
Topics: Androstadienes; Chemokine CCL2; Chromones; Endothelium, Vascular; Humans; Interleukin-1; Morpholines; NF-kappa B; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Piperazines; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; RNA, Messenger; Umbilical Veins; Wortmannin | 2004 |
LY294002 and LY303511 sensitize tumor cells to drug-induced apoptosis via intracellular hydrogen peroxide production independent of the phosphoinositide 3-kinase-Akt pathway.
Topics: Apoptosis; Caspase Inhibitors; Catalase; Cell Growth Processes; Cell Line, Tumor; Chromones; Enzyme Inhibitors; HL-60 Cells; Humans; Hydrogen Peroxide; Male; Morpholines; Neoplastic Stem Cells; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Piperazines; Prostatic Neoplasms; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Transfection; Vincristine | 2005 |
Enhancement of cytokine-mediated NF-kappaB activation by phosphatidylinositol 3-kinase inhibitors in monocytic cells.
Topics: Active Transport, Cell Nucleus; Cell Line; Cell Line, Tumor; Cell Nucleus; Chromones; Cyclooxygenase 2; Cytokines; Endothelial Cells; Enzyme Inhibitors; Epithelial Cells; Gene Expression; HL-60 Cells; Humans; I-kappa B Kinase; Interleukin-1; Lipopolysaccharides; Lymphocytes; Membrane Proteins; Monocytes; Morpholines; NF-kappa B; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Piperazines; Protein Binding; Tumor Necrosis Factor-alpha | 2006 |
Signaling in lipopolysaccharide-induced stabilization of formyl peptide receptor 1 mRNA in mouse peritoneal macrophages.
Topics: 3' Untranslated Regions; Androstadienes; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cell-Free System; Chromones; Female; Gene Expression Regulation; I-kappa B Kinase; Lipopolysaccharides; Macrophages, Peritoneal; Mice; Morpholines; p38 Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Piperazines; Protein Kinase Inhibitors; Protein Kinases; Receptors, Formyl Peptide; Ribosomal Protein S6 Kinases, 70-kDa; RNA Stability; RNA, Messenger; Sesquiterpenes; Signal Transduction; Toll-Like Receptor 4; TOR Serine-Threonine Kinases; Wortmannin | 2007 |
Positive regulation of tumor necrosis factor-alpha by ganglioside GM3 through Akt in mouse melanoma B16 cells.
Topics: Androstadienes; Animals; Chromones; G(M3) Ganglioside; Melanoma; Mice; Morpholines; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Piperazines; Proto-Oncogene Proteins c-akt; Signal Transduction; Skin Neoplasms; Tumor Cells, Cultured; Tumor Necrosis Factor-alpha; Wortmannin | 2007 |
LY303511 amplifies TRAIL-induced apoptosis in tumor cells by enhancing DR5 oligomerization, DISC assembly, and mitochondrial permeabilization.
Topics: Apoptosis; Caspase 8; Cell Line, Tumor; Chromones; Cytochromes c; Death Domain Receptor Signaling Adaptor Proteins; Dose-Response Relationship, Drug; HeLa Cells; HT29 Cells; Humans; Mitochondria; Mitochondrial Membranes; Morpholines; Piperazines; Receptors, TNF-Related Apoptosis-Inducing Ligand; TNF-Related Apoptosis-Inducing Ligand | 2007 |
PI3K/akt, JAK/STAT and MEK/ERK pathway inhibition protects retinal ganglion cells via different mechanisms after optic nerve injury.
Topics: Analgesics, Non-Narcotic; Animals; Axons; Axotomy; Blotting, Western; Butadienes; Chromones; Clodronic Acid; Enzyme Inhibitors; Extracellular Signal-Regulated MAP Kinases; Flavonoids; Immunohistochemistry; Janus Kinases; Macrophages; Morpholines; Neuroprotective Agents; Nitriles; Optic Nerve Injuries; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Piperazines; Proto-Oncogene Proteins c-akt; Rats; Rats, Inbred F344; Retinal Ganglion Cells; Signal Transduction; STAT Transcription Factors; Tyrphostins | 2007 |
Detailed molecular analysis of the induction of the L-PK gene by glucose.
Topics: Acetylation; Animals; Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; Cell Line, Tumor; Chromones; Gene Expression Regulation; Glucose; Hepatocyte Nuclear Factor 4; Histones; Liver; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Piperazines; Promoter Regions, Genetic; Pyruvate Kinase; Rats; RNA Polymerase II; RNA Stability; RNA, Messenger; Serine; Transcription Initiation Site; Transcription, Genetic | 2008 |
LY294002 inhibits glucocorticoid-induced COX-2 gene expression in cardiomyocytes through a phosphatidylinositol 3 kinase-independent mechanism.
Topics: Androstadienes; Animals; Animals, Newborn; Calcium; Calcium Channel Blockers; Chromones; Cyclooxygenase 2; Dose-Response Relationship, Drug; Enzyme Induction; Glucocorticoids; Morpholines; Myocytes, Cardiac; Nimodipine; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Piperazines; Potassium Channel Blockers; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Receptors, Glucocorticoid; Signal Transduction; Tetraethylammonium; Time Factors; Wortmannin | 2008 |
LY294002 inhibits leukemia cell invasion and migration through early growth response gene 1 induction independent of phosphatidylinositol 3-kinase-Akt pathway.
Topics: Cell Movement; Chromones; Early Growth Response Protein 1; Gene Expression; HL-60 Cells; Humans; Leukemia, Promyelocytic, Acute; Morpholines; Neoplasm Invasiveness; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Piperazines; Protein Kinase Inhibitors; Proto-Oncogene Proteins c-akt | 2008 |
Intracellular signal transduction pathways in the regulation of fowl sperm motility: evidence for the involvement of phosphatidylinositol 3-kinase (PI3-K) cascade.
Topics: Adenosine Triphosphate; Animals; Chickens; Chromones; Enzyme Inhibitors; Linear Models; Male; Morpholines; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Piperazines; Proto-Oncogene Proteins c-akt; Signal Transduction; Sperm Motility; Spermatozoa; Statistics, Nonparametric; Time Factors | 2009 |
Regulation of Kir channels in bovine retinal pigment epithelial cells by phosphatidylinositol 4,5-bisphosphate.
Topics: 1-Phosphatidylinositol 4-Kinase; Adenosine Triphosphate; Androstadienes; Animals; Cattle; Chromones; Ion Channel Gating; Magnesium; Morpholines; Neomycin; Patch-Clamp Techniques; Phosphatidylinositol 3-Kinases; Phosphatidylinositol 4,5-Diphosphate; Phosphatidylinositols; Phosphoinositide-3 Kinase Inhibitors; Pigment Epithelium of Eye; Piperazines; Potassium Channels, Inwardly Rectifying; Wortmannin | 2009 |
Effect of phosphatidylinositol-3 kinase inhibition on ovotoxicity caused by 4-vinylcyclohexene diepoxide and 7, 12-dimethylbenz[a]anthracene in neonatal rat ovaries.
Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Animals, Newborn; Chromones; Cyclohexenes; Female; In Vitro Techniques; Morpholines; Ovarian Diseases; Ovarian Follicle; Phosphoinositide-3 Kinase Inhibitors; Piperazines; Rats; Time Factors; Vinyl Compounds | 2009 |
Homotypic gap junctional communication associated with metastasis suppression increases with PKA activity and is unaffected by PI3K inhibition.
Topics: Androstadienes; Cell Communication; Cell Line, Tumor; Cell Membrane; Chromones; Connexin 43; Cyclic AMP-Dependent Protein Kinases; Cytosol; Enzyme Activation; Enzyme Inhibitors; Fluoresceins; Fluorescent Antibody Technique; Gap Junctions; Humans; Immunoblotting; Isoquinolines; Morpholines; Neoplasm Metastasis; Neoplasms; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Piperazines; Proto-Oncogene Proteins c-akt; Signal Transduction; Sulfonamides; Wortmannin | 2010 |
LY294002 enhances expression of proteins encoded by recombinant replication-defective adenoviruses via mTOR- and non-mTOR-dependent mechanisms.
Topics: Adenoviridae; Antineoplastic Agents; Blotting, Western; Cell Line, Tumor; Chromones; Flow Cytometry; Gene Expression; Humans; Morpholines; Piperazines; Recombinant Proteins; TOR Serine-Threonine Kinases | 2013 |
The commonly used PI3-kinase probe LY294002 is an inhibitor of BET bromodomains.
Topics: Cell Cycle Proteins; Cell Line; Chromones; Crystallography, X-Ray; Enzyme Inhibitors; HEK293 Cells; Humans; Models, Molecular; Morpholines; Nuclear Proteins; Phosphoinositide-3 Kinase Inhibitors; Piperazines; Protein Serine-Threonine Kinases; RNA-Binding Proteins; Transcription Factors | 2014 |