ly 300164 has been researched along with gyki 52466 in 15 studies
| Studies (ly 300164) | Trials (ly 300164) | Recent Studies (post-2010) (ly 300164) | Studies (gyki 52466) | Trials (gyki 52466) | Recent Studies (post-2010) (gyki 52466) |
|---|---|---|---|---|---|
| 73 | 7 | 12 | 312 | 0 | 38 |
| Protein | Taxonomy | ly 300164 (IC50) | gyki 52466 (IC50) |
|---|---|---|---|
| Glutamate receptor 1 | Rattus norvegicus (Norway rat) | 10 | |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | 10 | |
| Glutamate receptor 3 | Rattus norvegicus (Norway rat) | 10 | |
| Glutamate receptor 4 | Rattus norvegicus (Norway rat) | 10 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (13.33) | 18.2507 |
| 2000's | 13 (86.67) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Andrási, F; Berzsenyi, P; Hámori, T; Sólyom, S; Tarnawa, I | 1 |
| Barreca, ML; Chimirri, A; Constanti, A; De Luca, L; De Sarro, G; Ferreri, G; Gitto, R; Quartarone, S; Russo, E | 1 |
| Chimirri, A; De Sarro, A; De Sarro, G; Ferreri, G; Gitto, R; Orlando, V; Quartarone, S; Russo, E | 1 |
| Caruso, R; Chimirri, A; Citraro, R; De Luca, L; De Sarro, G; Gitto, R; Pagano, B; Russo, E | 1 |
| Cagnotto, A; Colleoni, S; Diana, V; Grasso, S; Lazzaro, J; Mennini, T; Micale, N; Pellicanò, A; Postorino, G; Zappalà, M | 1 |
| Ballyk, BA; Bath, CP; Bleakman, D; Bufton, HR; Kamboj, RK; Lodge, D; Palmer, AJ; Schoepp, DD; Sharpe, EF; Tarnawa, I; Woolley, ML | 1 |
| Gacsályi, I; Gigler, G; Gyertyán, I; Lévay, G; Szabados, T | 2 |
| Banczerowski-Pelyhe, I; Gulyás-Kovács, A; Takács, J; Tarnawa, I; Világi, I | 1 |
| Barreca, ML; Caruso, R; Chimirri, A; De Sarro, G; Ferreri, G; Gitto, R; Orlando, V; Quartarone, S; Russo, E | 1 |
| Ando, RD; Bagdy, G; Balogh, B; Gacsalyi, I; Graf, M; Jakus, R; Kantor, S; Levay, G | 1 |
| Andrási, F; Berzsenyi, P; Botka, P; Farkas, L; Hámori, T; Körösi, J; Láng, T; Ling, I | 1 |
| Barkoczy, J; Gigler, G; Gressens, P; Harsing, LG; Kapus, G; Kertesz, S; Levay, G; Medja, F; Spedding, M; Szenasi, G; Villa, P; Williamson, T | 1 |
| Barreca, ML; Caruso, R; Chimirri, A; Citraro, R; De Luca, L; De Sarro, G; Gitto, R; Quartarone, S | 1 |
| Gacsalyi, I; Harsing, LG; Juranyi, Z; Levay, G; Marko, B; Megyeri, K; Sziray, N | 1 |
15 other study(ies) available for ly 300164 and gyki 52466
| Article | Year |
|---|---|
Structural analogues of some highly active non-competitive AMPA antagonists.
Topics: Animals; Anti-Anxiety Agents; Anticonvulsants; Azepines; Behavior, Animal; Benzodiazepines; Brain Ischemia; Cells, Cultured; Chickens; Electroshock; Humans; Mice; Patch-Clamp Techniques; Purkinje Cells; Rats; Receptors, AMPA; Retina; Structure-Activity Relationship | 2000 |
Discovery of a novel and highly potent noncompetitive AMPA receptor antagonist.
Topics: Acoustic Stimulation; Animals; Anticonvulsants; Excitatory Amino Acid Antagonists; Isoquinolines; Ligands; Mice; Mice, Inbred DBA; Receptors, AMPA; Seizures; Structure-Activity Relationship; Tetrahydroisoquinolines | 2003 |
Synthesis and evaluation of pharmacological properties of novel annelated 2,3-benzodiazepine derivatives.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Benzodiazepines; Disease Models, Animal; Epilepsy; Excitatory Amino Acid Agonists; In Vitro Techniques; Magnetic Resonance Spectroscopy; Mice; Mice, Inbred DBA; Neurons; Olfactory Pathways; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Structure-Activity Relationship; Triazoles | 2003 |
Novel potent anticonvulsant agent containing a tetrahydroisoquinoline skeleton.
Topics: Acoustic Stimulation; Animals; Anticonvulsants; In Vitro Techniques; Isoquinolines; Male; Mice; Mice, Inbred DBA; Olfactory Pathways; Piperidines; Rats; Rats, Wistar; Receptors, AMPA; Seizures; Structure-Activity Relationship; Tetrahydroisoquinolines | 2006 |
Structure-activity study of 2,3-benzodiazepin-4-ones noncompetitive AMPAR antagonists: identification of the 1-(4-amino-3-methylphenyl)-3,5-dihydro-7,8-ethylenedioxy-4H-2,3-benzodiazepin-4-one as neuroprotective agent.
Topics: Animals; Benzodiazepines; Benzodiazepinones; Calcium; Cells, Cultured; Hippocampus; Inhibitory Concentration 50; Kainic Acid; Ligands; Mice; Molecular Structure; Neurons; Neuroprotective Agents; Protein Binding; Receptors, AMPA; Structure-Activity Relationship | 2008 |
Activity of 2,3-benzodiazepines at native rat and recombinant human glutamate receptors in vitro: stereospecificity and selectivity profiles.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anti-Anxiety Agents; Benzodiazepines; Benzothiadiazines; Cell Line; Cerebellum; Cerebral Cortex; Excitatory Amino Acid Antagonists; Ganglia, Spinal; Humans; Kidney; Membrane Potentials; Molecular Structure; Neurons; Purkinje Cells; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Recombinant Proteins; Spinal Cord; Structure-Activity Relationship; Transfection | 1996 |
Duration of action of GYKI 52466 and its analogues in antiepileptic, anti-ischaemic and muscle relaxant tests.
Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Brain Ischemia; Epilepsy; Excitatory Amino Acid Antagonists; Mice; Muscle Relaxants, Central | 1999 |
Comparison of anticonvulsive and acute neuroprotective activity of three 2,3-benzodiazepine compounds, GYKI 52466, GYKI 53405, and GYKI 53655.
Topics: Acoustic Stimulation; Animals; Anti-Anxiety Agents; Anticonvulsants; Benzodiazepines; Brain Ischemia; Dose-Response Relationship, Drug; Electroshock; Magnesium Chloride; Male; Mice; Mice, Inbred Strains; Neuroprotective Agents; Seizures; Survival Analysis; Time Factors | 2001 |
Protective effect of the antiepileptic drug candidate talampanel against AMPA-induced striatal neurotoxicity in neonatal rats.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Anti-Anxiety Agents; Asphyxia Neonatorum; Behavior, Animal; Benzodiazepines; Cell Death; Epilepsy; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Humans; Hypoxia-Ischemia, Brain; Infant, Newborn; Male; Movement Disorders; Neostriatum; Neuroprotective Agents; Neurotoxins; Rats; Receptors, AMPA; Synaptic Transmission | 2002 |
Synthesis and anticonvulsant properties of tetrahydroisoquinoline derivatives.
Topics: Animals; Anticonvulsants; Benzodiazepines; Benzodiazepinones; Drug Evaluation, Preclinical; Excitatory Amino Acid Antagonists; Female; Male; Mice; Mice, Inbred DBA; Models, Molecular; Molecular Structure; Receptors, AMPA; Seizures; Structure-Activity Relationship; Tetrahydroisoquinolines | 2004 |
Effect of two noncompetitive AMPA receptor antagonists GYKI 52466 and GYKI 53405 on vigilance, behavior and spike-wave discharges in a genetic rat model of absence epilepsy.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Arousal; Behavior, Animal; Benzodiazepines; Dose-Response Relationship, Drug; Electroencephalography; Electromyography; Epilepsy, Absence; Excitatory Amino Acid Antagonists; Male; Rats; Receptors, AMPA; Serotonin Receptor Agonists; Sleep; Wakefulness | 2004 |
Omeprazole and talampanel as two examples of retrometabolic drug design.
Topics: Anticonvulsants; Benzodiazepines; Drug Design; Enzyme Inhibitors; Indicators and Reagents; Omeprazole; Proton Pump Inhibitors; Structure-Activity Relationship | 2004 |
The effects of AMPA receptor antagonists in models of stroke and neurodegeneration.
Topics: Animals; Animals, Newborn; Anticonvulsants; Benzodiazepines; Brain; Brain Ischemia; Cell Survival; Chickens; Cortical Spreading Depression; Disease Models, Animal; Dose-Response Relationship, Drug; Electroshock; Excitatory Amino Acid Antagonists; Infarction, Middle Cerebral Artery; Male; Mice; Mice, Inbred Strains; Motor Neurons; Nerve Degeneration; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Retina; Seizures; Stroke | 2005 |
3D pharmacophore models for 1,2,3,4-tetrahydroisoquinoline derivatives acting as anticonvulsant agents.
Topics: Animals; Anticonvulsants; Benzodiazepines; Drug Design; Drug Evaluation, Preclinical; Epilepsy, Reflex; Female; Isoquinolines; Male; Mice; Mice, Inbred DBA; Models, Animal; Models, Molecular; Molecular Conformation; Molecular Structure; Structure-Activity Relationship; Tetrahydroisoquinolines | 2006 |
Effects of 2,3-benzodiazepine AMPA receptor antagonists on dopamine turnover in the striatum of rats with experimental parkinsonism.
Topics: 3,4-Dihydroxyphenylacetic Acid; Analysis of Variance; Animals; Benzodiazepines; Corpus Striatum; Dopamine; Dopamine Agents; Drug Interactions; Functional Laterality; Homovanillic Acid; Levodopa; Male; Oxidopamine; Parkinsonian Disorders; Rats; Rats, Sprague-Dawley; Receptors, AMPA | 2007 |