Compounds > ly 293558
Page last updated: 2024-09-03

ly 293558 and tetrodotoxin

ly 293558 has been researched along with tetrodotoxin in 3 studies

Compound Research Comparison

Studies
(ly 293558)		Trials
(ly 293558)		Recent Studies (post-2010)
(ly 293558)		Studies
(tetrodotoxin)		Trials
(tetrodotoxin)		Recent Studies (post-2010) (tetrodotoxin)
10341812,992111,477
10341820015

Protein Interaction Comparison

ProteinTaxonomyly 293558 (IC50)tetrodotoxin (IC50)
Sodium channel protein type 9 subunit alphaHomo sapiens (human)0.0203
Sodium channel protein type 11 subunit alphaRattus norvegicus (Norway rat)1
Sodium channel protein type 1 subunit alphaRattus norvegicus (Norway rat)0.01
Sodium channel protein type 2 subunit alphaRattus norvegicus (Norway rat)0.0093
Sodium channel protein type 3 subunit alphaRattus norvegicus (Norway rat)0.015
Sodium channel protein type 5 subunit alphaRattus norvegicus (Norway rat)2
Sodium channel protein type 1 subunit alphaHomo sapiens (human)0.017
Sodium channel protein type 4 subunit alphaHomo sapiens (human)0.0209
Sodium channel protein type 7 subunit alphaHomo sapiens (human)0.036
Sodium channel protein type 5 subunit alphaHomo sapiens (human)1
Sodium channel protein type 2 subunit alphaHomo sapiens (human)0.022
Sodium channel protein type 3 subunit alphaHomo sapiens (human)0.0176
Sodium channel protein type 11 subunit alphaHomo sapiens (human)0.03
Sodium channel protein type 8 subunit alphaHomo sapiens (human)0.0161
Sodium channel protein type 8 subunit alphaMus musculus (house mouse)0.006

Research

Studies (3)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (33.33)18.2507
2000's1 (33.33)29.6817
2010's1 (33.33)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
McGinty, JF; Rawls, SM1
Aghajanian, GK; Jolas, T; Nestler, EJ1
Bagal, SK; Brown, AD; Cox, PJ; Omoto, K; Owen, RM; Pryde, DC; Sidders, B; Skerratt, SE; Stevens, EB; Storer, RI; Swain, NA1

Reviews

1 review(s) available for ly 293558 and tetrodotoxin

ArticleYear
Ion channels as therapeutic targets: a drug discovery perspective.
    Journal of medicinal chemistry, 2013, Feb-14, Volume: 56, Issue:3

    Topics: Drug Discovery; Humans; Ion Channels; Models, Molecular; Phylogeny

2013

Other Studies

2 other study(ies) available for ly 293558 and tetrodotoxin

ArticleYear
L-trans-pyrrolidine-2,4-dicarboxylic acid-evoked striatal glutamate levels are attenuated by calcium reduction, tetrodotoxin, and glutamate receptor blockade.
    Journal of neurochemistry, 1997, Volume: 68, Issue:4

    Topics: Animals; Calcium; Chromatography, High Pressure Liquid; Dicarboxylic Acids; Excitatory Amino Acid Antagonists; Glutamic Acid; Isoquinolines; Male; Microdialysis; Neostriatum; Neurotransmitter Uptake Inhibitors; Oxidation-Reduction; Piperazines; Pyrrolidines; Rats; Rats, Wistar; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Tetrazoles; Tetrodotoxin

1997
Chronic morphine increases GABA tone on serotonergic neurons of the dorsal raphe nucleus: association with an up-regulation of the cyclic AMP pathway.
    Neuroscience, 2000, Volume: 95, Issue:2

    Topics: Adenylyl Cyclases; Analgesics, Opioid; Animals; Cardiovascular Agents; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Electrophysiology; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enzyme Inhibitors; Excitatory Amino Acid Agonists; gamma-Aminobutyric Acid; In Vitro Techniques; Interneurons; Isoquinolines; Male; Membrane Potentials; Morphine; N-Methylaspartate; Neural Inhibition; Periaqueductal Gray; Phenylephrine; Pyrimidines; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Serotonin; Substance Withdrawal Syndrome; Sulfonamides; Sympathomimetics; Tetrazoles; Tetrodotoxin; Thionucleotides

2000