Page last updated: 2024-09-03

ly 293558 and lofepramine hydrochloride

ly 293558 has been researched along with lofepramine hydrochloride in 6 studies

Compound Research Comparison

Studies
(ly 293558)
Trials
(ly 293558)
Recent Studies (post-2010)
(ly 293558)
Studies
(lofepramine hydrochloride)
Trials
(lofepramine hydrochloride)
Recent Studies (post-2010) (lofepramine hydrochloride)
1034181701

Protein Interaction Comparison

ProteinTaxonomyly 293558 (IC50)lofepramine hydrochloride (IC50)
Integrin beta-3Homo sapiens (human)0.35
Integrin alpha-IIbHomo sapiens (human)0.35
Glutamate receptor 1Rattus norvegicus (Norway rat)0.3371
Glutamate receptor 2Rattus norvegicus (Norway rat)0.3371
Glutamate receptor 3Rattus norvegicus (Norway rat)0.3371
Glutamate receptor 4Rattus norvegicus (Norway rat)0.3371
Glutamate receptor ionotropic, kainate 1Rattus norvegicus (Norway rat)0.28
Glutamate receptor ionotropic, NMDA 1 Rattus norvegicus (Norway rat)10
Glutamate receptor ionotropic, kainate 2Rattus norvegicus (Norway rat)0.28
Glutamate receptor ionotropic, kainate 3Rattus norvegicus (Norway rat)0.28
Glutamate receptor ionotropic, NMDA 2A Rattus norvegicus (Norway rat)10
Glutamate receptor ionotropic, NMDA 2BRattus norvegicus (Norway rat)10
Glutamate receptor ionotropic, NMDA 2CRattus norvegicus (Norway rat)10
Glutamate receptor ionotropic, kainate 4Rattus norvegicus (Norway rat)0.28
Glutamate receptor ionotropic, NMDA 2DRattus norvegicus (Norway rat)10
Glutamate receptor ionotropic, kainate 5Rattus norvegicus (Norway rat)0.28
Glutamate receptor ionotropic, NMDA 3BRattus norvegicus (Norway rat)10
P2Y purinoceptor 12Homo sapiens (human)0.35
Glutamate receptor ionotropic, NMDA 3ARattus norvegicus (Norway rat)10

Research

Studies (6)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (16.67)18.2507
2000's4 (66.67)29.6817
2010's1 (16.67)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Boireau, A; Chevé, M; Damour, D; Genevois-Borella, A; Imperato, A; Jimonet, P; Mignani, S; Pratt, J; Randle, JC; Ribeill, Y; Stutzmann, JM1
Bohme, GA; Boireau, A; Damour, D; Debono, MW; Genevois-Borella, A; Imperato, A; Jimonet, P; Mignani, S; Pratt, J; Randle, JC; Ribeill, Y; Stutzmann, JM; Vuilhorgne, M1
Bohme, GA; Boireau, A; Damour, D; Debono, MW; Genevois-Borella, A; Jimonet, P; Mignani, S; Pratt, J; Randle, JC; Ribeill, Y; Stutzmann, JM; Vuilhorgne, M2
Bohme, GA; Boireau, A; Bouquerel, J; Damour, D; Debono, MW; Genevois-Borella, A; Hardy, JC; Hubert, P; Jimonet, P; Manfré, F; Mignani, S; Nemecek, P; Pratt, J; Randle, JC; Ribeill, Y; Stutzmann, JM; Vuilhorgne, M1
Carcache, D; Kalkman, HO; Koller, M; Mattes, H1

Other Studies

6 other study(ies) available for ly 293558 and lofepramine hydrochloride

ArticleYear
Spiro-imidazo[1,2-a]indeno[1,2-e]pyrazine-4-one derivatives are mixed AMPA and NMDA glycine-site antagonists active in vivo.
    Bioorganic & medicinal chemistry letters, 1999, Oct-18, Volume: 9, Issue:20

    Topics: Animals; Binding Sites; Excitatory Amino Acid Antagonists; Glycine; Mice; Pyrazines; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Spiro Compounds; Structure-Activity Relationship

1999
4,10-Dihydro-4-oxo-4H-imidazo[1,2-a]indeno[1,2-e]pyrazin-2-carboxylic acid derivatives: highly potent and selective AMPA receptors antagonists with in vivo activity.
    Bioorganic & medicinal chemistry letters, 2000, May-15, Volume: 10, Issue:10

    Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Drug Evaluation, Preclinical; Inhibitory Concentration 50; Isoquinolines; Mice; Mice, Inbred DBA; Pyrazines; Quinoxalines; Rats; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship; Tetrazoles; Urea

2000
Synthesis and potent anticonvulsant activities of 4-oxo-imidazo[1,2-a]inden.
    Bioorganic & medicinal chemistry letters, 2000, Dec-18, Volume: 10, Issue:24

    Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Brain; Cell Membrane; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Routes; Excitatory Amino Acid Agonists; Heterocyclic Compounds, 4 or More Rings; Imidazoles; Inhibitory Concentration 50; Male; Mice; Mice, Inbred DBA; Oocytes; Protein Binding; Pyrazines; Rats; Receptors, AMPA; Seizures; Structure-Activity Relationship; Time Factors; Xenopus

2000
Bioisosteres of 9-carboxymethyl-4-oxo-imidazo[1,2-a]indeno-[1,2-e]pyrazin-2-carboxylic acid derivatives. Progress towards selective, potent in vivo AMPA antagonists with longer durations of action.
    Bioorganic & medicinal chemistry letters, 2001, Jan-22, Volume: 11, Issue:2

    Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Combinatorial Chemistry Techniques; Disease Models, Animal; Excitatory Amino Acid Antagonists; Imidazoles; Inhibitory Concentration 50; Male; Mice; Oocytes; Pyrazinamide; Pyrazines; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Seizures; Structure-Activity Relationship

2001
Synthesis of anticonvulsive AMPA antagonists: 4-oxo-10-substituted-imidaz.
    Bioorganic & medicinal chemistry letters, 2001, May-07, Volume: 11, Issue:9

    Topics: Animals; Anticonvulsants; Carboxylic Acids; Dose-Response Relationship, Drug; Electroshock; Injections, Intraperitoneal; Injections, Intravenous; Isoquinolines; Mice; Pyrazines; Quinoxalines; Rats; Receptors, AMPA; Structure-Activity Relationship; Tetrazoles; Xenopus

2001
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) antagonists: from bench to bedside.
    Journal of medicinal chemistry, 2010, Aug-12, Volume: 53, Issue:15

    Topics: Analgesics; Animals; Anticonvulsants; Antipsychotic Agents; Clinical Trials as Topic; Drug Evaluation, Preclinical; Humans; Neuroprotective Agents; Protein Subunits; Receptors, AMPA

2010