ly 293558 has been researched along with glutamic acid in 8 studies
| Studies (ly 293558) | Trials (ly 293558) | Recent Studies (post-2010) (ly 293558) | Studies (glutamic acid) | Trials (glutamic acid) | Recent Studies (post-2010) (glutamic acid) |
|---|---|---|---|---|---|
| 103 | 4 | 18 | 41,757 | 452 | 12,876 |
| Protein | Taxonomy | ly 293558 (IC50) | glutamic acid (IC50) |
|---|---|---|---|
| Chain A, GLUTAMATE RECEPTOR SUBUNIT 2 | Rattus norvegicus (Norway rat) | 0.821 | |
| Chain A, Glutamate Receptor Subunit 2 | Rattus norvegicus (Norway rat) | 0.821 | |
| Chain B, Glutamate Receptor Subunit 2 | Rattus norvegicus (Norway rat) | 0.821 | |
| Metabotropic glutamate receptor 8 | Homo sapiens (human) | 0.0057 | |
| Glutamate receptor ionotropic, NMDA 2D | Homo sapiens (human) | 0.07 | |
| Glutamate receptor ionotropic, NMDA 3B | Homo sapiens (human) | 0.07 | |
| Glutamate receptor 1 | Rattus norvegicus (Norway rat) | 0.5885 | |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | 0.5885 | |
| Glutamate receptor 3 | Rattus norvegicus (Norway rat) | 0.5885 | |
| Glutamate receptor 4 | Rattus norvegicus (Norway rat) | 0.5885 | |
| Glutamate receptor ionotropic, kainate 1 | Rattus norvegicus (Norway rat) | 0.38 | |
| Glutamate receptor ionotropic, NMDA 1 | Rattus norvegicus (Norway rat) | 0.1533 | |
| Glutamate receptor ionotropic, kainate 2 | Rattus norvegicus (Norway rat) | 0.38 | |
| Glutamate receptor 1 | Homo sapiens (human) | 0.613 | |
| Glutamate receptor 2 | Homo sapiens (human) | 0.613 | |
| Glutamate receptor 3 | Homo sapiens (human) | 0.613 | |
| Glutamate receptor ionotropic, kainate 3 | Rattus norvegicus (Norway rat) | 0.38 | |
| Excitatory amino acid transporter 1 | Homo sapiens (human) | 207 | |
| Glutamate receptor 4 | Homo sapiens (human) | 0.613 | |
| Glutamate receptor ionotropic, NMDA 2A | Rattus norvegicus (Norway rat) | 0.1533 | |
| Glutamate receptor ionotropic, NMDA 2B | Rattus norvegicus (Norway rat) | 0.1533 | |
| Glutamate receptor ionotropic, NMDA 2C | Rattus norvegicus (Norway rat) | 0.1533 | |
| Glutamate receptor ionotropic, kainate 4 | Rattus norvegicus (Norway rat) | 0.38 | |
| Glutamate receptor ionotropic, NMDA 1 | Homo sapiens (human) | 0.07 | |
| Glutamate receptor ionotropic, NMDA 2A | Homo sapiens (human) | 0.07 | |
| Glutamate receptor ionotropic, NMDA 2B | Homo sapiens (human) | 0.07 | |
| Glutamate receptor ionotropic, NMDA 2C | Homo sapiens (human) | 0.07 | |
| Glutamate receptor ionotropic, NMDA 2D | Rattus norvegicus (Norway rat) | 0.1533 | |
| Glutamate receptor ionotropic, kainate 5 | Rattus norvegicus (Norway rat) | 0.38 | |
| Glutamate receptor ionotropic, NMDA 3A | Homo sapiens (human) | 0.07 | |
| Glutamate receptor ionotropic, NMDA 3B | Rattus norvegicus (Norway rat) | 0.1533 | |
| Glutamate receptor ionotropic, NMDA 3A | Rattus norvegicus (Norway rat) | 0.1533 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (50.00) | 18.2507 |
| 2000's | 4 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cebers, G; Kalda, A; Liljequist, S | 1 |
| McGinty, JF; Rawls, SM | 1 |
| Adams, B; Daly, D; Moghaddam, B; Verma, A | 1 |
| Moghaddam, B; Takahata, R | 2 |
| Jackson, ME; Moghaddam, B | 1 |
| de Groat, WC; Yoshiyama, M | 1 |
| Brennan, TJ; Lee, HJ; Pogatzki-Zahn, EM | 1 |
8 other study(ies) available for ly 293558 and glutamic acid
| Article | Year |
|---|---|
Effects of decahydroisoquinoline-3-carboxylic acid monohydrate, a novel AMPA receptor antagonist, on glutamate-induced CA2+ responses and neurotoxicity in rat cortical and cerebellar granule neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Cells, Cultured; Cerebellum; Cerebral Cortex; Dose-Response Relationship, Drug; Glutamic Acid; Isoquinolines; Kainic Acid; N-Methylaspartate; Neurons; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Tetrazoles | 1995 |
L-trans-pyrrolidine-2,4-dicarboxylic acid-evoked striatal glutamate levels are attenuated by calcium reduction, tetrodotoxin, and glutamate receptor blockade.
Topics: Animals; Calcium; Chromatography, High Pressure Liquid; Dicarboxylic Acids; Excitatory Amino Acid Antagonists; Glutamic Acid; Isoquinolines; Male; Microdialysis; Neostriatum; Neurotransmitter Uptake Inhibitors; Oxidation-Reduction; Piperazines; Pyrrolidines; Rats; Rats, Wistar; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Tetrazoles; Tetrodotoxin | 1997 |
Activation of glutamatergic neurotransmission by ketamine: a novel step in the pathway from NMDA receptor blockade to dopaminergic and cognitive disruptions associated with the prefrontal cortex.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; Amino Acids; Analysis of Variance; Animals; Cognition; Corpus Striatum; Dopamine; Glutamic Acid; Homoserine; Isoquinolines; Ketamine; Maze Learning; Prefrontal Cortex; Rats; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Stereotaxic Techniques; Tetrazoles | 1997 |
Glutamatergic regulation of basal and stimulus-activated dopamine release in the prefrontal cortex.
Topics: 2-Amino-5-phosphonovalerate; Animals; Dopamine; Glutamic Acid; Handling, Psychological; Injections, Intraventricular; Isoquinolines; Male; Microdialysis; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate; Stress, Physiological; Tetrazoles; Ventral Tegmental Area; Wakefulness | 1998 |
Target-specific glutamatergic regulation of dopamine neurons in the ventral tegmental area.
Topics: Animals; Dopamine; Glutamic Acid; Isoquinolines; Male; Microdialysis; Neurons; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Tetrazoles; Ventral Tegmental Area; Wakefulness | 2000 |
Amygdala regulation of nucleus accumbens dopamine output is governed by the prefrontal cortex.
Topics: Amygdala; Animals; Appetitive Behavior; Behavior, Animal; Bridged Bicyclo Compounds; Dopamine; Electric Stimulation; Electrodes, Implanted; Excitatory Amino Acid Agonists; Glutamic Acid; Isoquinolines; Male; Microdialysis; Microinjections; Nucleus Accumbens; Prefrontal Cortex; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Stereotyped Behavior; Tetrazoles; Wakefulness | 2001 |
Supraspinal and spinal alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid and N-methyl-D-aspartate glutamatergic control of the micturition reflex in the urethane-anesthetized rat.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Anesthesia; Anesthetics, Intravenous; Animals; Brain; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Synergism; Electromyography; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Injections, Intraventricular; Injections, Spinal; Isoquinolines; N-Methylaspartate; Neural Pathways; Rats; Rats, Sprague-Dawley; Spinal Cord; Tetrazoles; Urethane; Urinary Bladder; Urination | 2005 |
The effect of the AMPA/kainate receptor antagonist LY293558 in a rat model of postoperative pain.
Topics: Afferent Pathways; Analgesics; Animals; Carboxylic Acids; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Routes; Excitatory Amino Acid Antagonists; Glutamic Acid; Hyperalgesia; Injections, Intraperitoneal; Injections, Spinal; Injections, Subcutaneous; Isoquinolines; Male; Nociceptors; Pain Measurement; Pain Threshold; Pain, Postoperative; Physical Stimulation; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Tetrazoles; Treatment Outcome | 2006 |