ly 293558 has been researched along with alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid in 13 studies
| Studies (ly 293558) | Trials (ly 293558) | Recent Studies (post-2010) (ly 293558) | Studies (alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) | Trials (alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) | Recent Studies (post-2010) (alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) |
|---|---|---|---|---|---|
| 103 | 4 | 18 | 2,899 | 11 | 609 |
| Protein | Taxonomy | ly 293558 (IC50) | alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (IC50) |
|---|---|---|---|
| Glutamate receptor 1 | Rattus norvegicus (Norway rat) | 0.157 | |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | 0.1765 | |
| Glutamate receptor 3 | Rattus norvegicus (Norway rat) | 0.1765 | |
| Glutamate receptor 4 | Rattus norvegicus (Norway rat) | 0.1765 | |
| Glutamate receptor 1 | Mus musculus (house mouse) | 0.04 | |
| Glutamate receptor 2 | Mus musculus (house mouse) | 0.04 | |
| Glutamate receptor 1 | Homo sapiens (human) | 0.1353 | |
| Glutamate receptor 2 | Homo sapiens (human) | 0.1353 | |
| Glutamate receptor 3 | Homo sapiens (human) | 0.1353 | |
| Glutamate receptor 4 | Homo sapiens (human) | 0.1353 | |
| Glutamate receptor 4 | Mus musculus (house mouse) | 0.04 | |
| Glutamate receptor 3 | Mus musculus (house mouse) | 0.04 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 10 (76.92) | 18.2507 |
| 2000's | 3 (23.08) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Burnett, JP; Desai, MA; Ornstein, PL; Schoepp, DD | 1 |
| Benvenga, MJ; Leander, JD; Ornstein, PL | 1 |
| Huang, M; LeBlanc, MH; Li, XQ; Patel, DM; Smith, EE | 1 |
| Bleakman, D; Leander, JD; Lodge, D; Ornstein, PL; Palmer, AJ; Salhoff, CR; Schoepp, DD; Tizzano, JP; Wright, RA | 1 |
| Cebers, G; Kalda, A; Liljequist, S | 1 |
| Bowes, MP; Swanson, S; Zivin, JA | 1 |
| Fuson, KS; May, PC; Ornstein, PL; Sacaan, AI; Salhoff, CR; Schoepp, DD; Tizzano, JP | 1 |
| Beart, PM; Cheung, NS; Larm, JA | 1 |
| Bleakman, D; Bristow, DR; Savidge, JR | 1 |
| Bleakman, D; Hoo, K; Ogden, AM; Ornstein, PL | 1 |
| Cebers, G; Kovács, AD; Liljequist, S | 1 |
| Bohme, GA; Boireau, A; Damour, D; Debono, MW; Genevois-Borella, A; Imperato, A; Jimonet, P; Mignani, S; Pratt, J; Randle, JC; Ribeill, Y; Stutzmann, JM; Vuilhorgne, M | 1 |
| de Groat, WC; Yoshiyama, M | 1 |
13 other study(ies) available for ly 293558 and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid
| Article | Year |
|---|---|
Cyclothiazide acts at a site on the alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor complex that does not recognize competitive or noncompetitive AMPA receptor antagonists.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzodiazepines; Benzothiadiazines; Binding Sites; Binding, Competitive; Hippocampus; In Vitro Techniques; Isoquinolines; Kainic Acid; Male; Norepinephrine; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Tetrazoles | 1995 |
Schedule-controlled behavioral effects of the selective 2-amino-3-(5-methyl-3-hydroxyisoxazol-4-yl)propanoic acid antagonist LY293558 in pigeons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Behavior, Animal; Columbidae; Electroshock; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Isoquinolines; Isoxazoles; Male; N-Methylaspartate; Propionates; Receptors, AMPA; Receptors, Glutamate; Receptors, N-Methyl-D-Aspartate; Reinforcement Schedule; Stereoisomerism; Tetrazoles | 1995 |
AMPA antagonist LY293558 does not affect the severity of hypoxic-ischemic injury in newborn pigs.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Animals, Newborn; Blood Pressure; Body Temperature; Brain; Brain Ischemia; Carbon Dioxide; Disease Models, Animal; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Heart Rate; Hydrogen-Ion Concentration; Hypnotics and Sedatives; Hypoxia, Brain; Isoquinolines; Oxygen; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Swine; Tetrazoles; Time Factors | 1995 |
In vitro and in vivo antagonism of AMPA receptor activation by (3S, 4aR, 6R, 8aR)-6-[2-(1(2)H-tetrazole-5-yl) ethyl] decahydroisoquinoline-3-carboxylic acid.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Brain; Dose-Response Relationship, Drug; In Vitro Techniques; Isoquinolines; Male; Mice; N-Methylaspartate; Quisqualic Acid; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Tetrazoles; Time Factors | 1995 |
Effects of decahydroisoquinoline-3-carboxylic acid monohydrate, a novel AMPA receptor antagonist, on glutamate-induced CA2+ responses and neurotoxicity in rat cortical and cerebellar granule neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Calcium; Cells, Cultured; Cerebellum; Cerebral Cortex; Dose-Response Relationship, Drug; Glutamic Acid; Isoquinolines; Kainic Acid; N-Methylaspartate; Neurons; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Tetrazoles | 1995 |
The AMPA antagonist LY293558 improves functional neurological outcome following reversible spinal cord ischemia in rabbits.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Blood Pressure; Ischemia; Ischemic Attack, Transient; Isoquinolines; Kinetics; Male; Paraplegia; Rabbits; Reperfusion Injury; Spinal Cord; Tetrazoles | 1996 |
Selective protection against AMPA- and kainate-evoked neurotoxicity by (3S,4aR,6R,8aR)-6-[2-(1(2)H-tetrazole-5-yl)ethyl]decahyd roisoquinoline- 3-carboxylic acid (LY293558) and its racemate (LY215490).
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Cells, Cultured; Excitatory Amino Acid Antagonists; Isoquinolines; Kainic Acid; Male; Mice; Mice, Inbred Strains; Neuroprotective Agents; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Kainic Acid; Seizures; Stereoisomerism; Tetrazoles | 1996 |
Apoptosis induced via AMPA-selective glutamate receptors in cultured murine cortical neurons.
Topics: 6-Cyano-7-nitroquinoxaline-2,3-dione; alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Apoptosis; Cells, Cultured; Cerebral Cortex; Chromatin; DNA Fragmentation; Electrophoresis, Agar Gel; Embryo, Mammalian; Embryo, Nonmammalian; Isoquinolines; Neurites; Neurons; Receptors, AMPA; Tetrazoles | 1997 |
Identification of kainate receptor-mediated intracellular calcium increases in cultured rat cerebellar granule cells.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzodiazepines; Calcium; Cells, Cultured; Cerebellum; Concanavalin A; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Intracellular Membranes; Isoquinolines; Kainic Acid; Neurons; Rats; Receptors, Kainic Acid; Tetrazoles | 1997 |
Pharmacological characterization of a GluR6 kainate receptor in cultured hippocampal neurons.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding, Competitive; Cell Line; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Gene Expression; GluK2 Kainate Receptor; Glutamates; Hippocampus; Humans; Isoquinolines; Kainic Acid; Membrane Potentials; Neurons; Patch-Clamp Techniques; Quinoxalines; Radioligand Assay; Receptors, AMPA; Receptors, Kainic Acid; Recombinant Fusion Proteins; Tetrazoles | 1999 |
Kainate receptor-mediated activation of the AP-1 transcription factor complex in cultured rat cerebellar granule cells.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Benzodiazepines; Benzothiadiazines; Cells, Cultured; Cerebellum; Concanavalin A; Dimerization; Excitatory Amino Acid Antagonists; Isoquinolines; Kainic Acid; Neurons; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Kainic Acid; Tetrazoles; Transcription Factor AP-1 | 2000 |
4,10-Dihydro-4-oxo-4H-imidazo[1,2-a]indeno[1,2-e]pyrazin-2-carboxylic acid derivatives: highly potent and selective AMPA receptors antagonists with in vivo activity.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Drug Evaluation, Preclinical; Inhibitory Concentration 50; Isoquinolines; Mice; Mice, Inbred DBA; Pyrazines; Quinoxalines; Rats; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship; Tetrazoles; Urea | 2000 |
Supraspinal and spinal alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid and N-methyl-D-aspartate glutamatergic control of the micturition reflex in the urethane-anesthetized rat.
Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Anesthesia; Anesthetics, Intravenous; Animals; Brain; Dizocilpine Maleate; Dose-Response Relationship, Drug; Drug Synergism; Electromyography; Excitatory Amino Acid Antagonists; Female; Glutamic Acid; Injections, Intraventricular; Injections, Spinal; Isoquinolines; N-Methylaspartate; Neural Pathways; Rats; Rats, Sprague-Dawley; Spinal Cord; Tetrazoles; Urethane; Urinary Bladder; Urination | 2005 |