Compounds > ly 293558
Page last updated: 2024-09-03

ly 293558 and 2,3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline

ly 293558 has been researched along with 2,3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline in 13 studies

Compound Research Comparison

Studies
(ly 293558)		Trials
(ly 293558)		Recent Studies (post-2010)
(ly 293558)		Studies
(2,3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline)		Trials
(2,3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline)		Recent Studies (post-2010) (2,3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline)
1034181,2160229

Protein Interaction Comparison

ProteinTaxonomyly 293558 (IC50)2,3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline (IC50)
Glutamate receptor 1Rattus norvegicus (Norway rat)0.5781
Glutamate receptor 2Rattus norvegicus (Norway rat)0.5781
Glutamate receptor 3Rattus norvegicus (Norway rat)0.5781
Glutamate receptor 4Rattus norvegicus (Norway rat)0.5781
Glutamate receptor ionotropic, kainate 1Rattus norvegicus (Norway rat)2.909
Glutamate receptor ionotropic, NMDA 1 Rattus norvegicus (Norway rat)0.2
Glutamate receptor ionotropic, kainate 2Rattus norvegicus (Norway rat)2.909
Glutamate receptor 1Homo sapiens (human)6
Glutamate receptor 2Homo sapiens (human)2.5
Glutamate receptor 3Homo sapiens (human)1.9
Glutamate receptor ionotropic, kainate 3Rattus norvegicus (Norway rat)2.909
Glutamate receptor 4Homo sapiens (human)1.1
Glutamate receptor ionotropic, NMDA 2A Rattus norvegicus (Norway rat)0.2
Glutamate receptor ionotropic, NMDA 2BRattus norvegicus (Norway rat)0.2
Glutamate receptor ionotropic, NMDA 2CRattus norvegicus (Norway rat)0.2
Glutamate receptor ionotropic, kainate 4Rattus norvegicus (Norway rat)2.909
Glutamate receptor ionotropic, NMDA 2DRattus norvegicus (Norway rat)0.2
Glutamate receptor ionotropic, kainate 5Rattus norvegicus (Norway rat)2.909
Glutamate receptor ionotropic, NMDA 3BRattus norvegicus (Norway rat)0.2
Glutamate receptor ionotropic, NMDA 3ARattus norvegicus (Norway rat)0.2

Research

Studies (13)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's5 (38.46)18.2507
2000's7 (53.85)29.6817
2010's1 (7.69)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Bohme, GA; Boireau, A; Damour, D; Debono, MW; Genevois-Borella, A; Imperato, A; Jimonet, P; Mignani, S; Pratt, J; Randle, JC; Ribeill, Y; Stutzmann, JM; Vuilhorgne, M1
Bohme, GA; Boireau, A; Damour, D; Debono, MW; Genevois-Borella, A; Jimonet, P; Mignani, S; Pratt, J; Randle, JC; Ribeill, Y; Stutzmann, JM; Vuilhorgne, M2
Bohme, GA; Boireau, A; Bouquerel, J; Damour, D; Debono, MW; Genevois-Borella, A; Hardy, JC; Hubert, P; Jimonet, P; Manfré, F; Mignani, S; Nemecek, P; Pratt, J; Randle, JC; Ribeill, Y; Stutzmann, JM; Vuilhorgne, M1
Bell, MG; Bleakman, D; Bleisch, TJ; Castaño, AM; Clemens-Smith, A; del Prado, M; Dieckman, DK; Dominguez, E; Escribano, A; Filla, SA; Ho, KH; Hudziak, KJ; Johnson, KW; Katofiasc, MA; Martinez-Perez, JA; Mateo, A; Mathes, BM; Mattiuz, EL; Ogden, AM; Ornstein, PL; Phebus, LA; Stack, DR; Stratford, RE; Winter, MA1
Alt, A; Arnold, BM; Bell, MG; Bleakman, D; Bleisch, TJ; Buckmaster, JL; Castano, AM; Del Prado, M; Dominguez, E; Escribano, A; Filla, SA; Ho, KH; Hudziak, KJ; Iyengar, S; Jones, CK; Martinez-Perez, JA; Mateo, A; Mathes, BM; Mattiuz, EL; Ogden, AM; Ornstein, PL; Shannon, HE; Simmons, RM; Stack, DR; Stratford, RE; Winter, MA; Wu, Z1
Carcache, D; Kalkman, HO; Koller, M; Mattes, H1
Browne, SE; McCulloch, J1
Ballyk, B; Bleakman, R; Bufton, H; Kamboj, RK; Ornstein, PL; Schoepp, DD; Sharpe, EF; Thomas, K1
Vanover, KE1
Deverill, M; Hoo, KH; Iyengar, S; Li, DL; Ornstein, PL; Simmons, RM1
Bleakman, D; Hoo, K; Ogden, AM; Ornstein, PL1
Bogaert, L; Bond, A; Ebinger, G; Hicks, CA; Lodge, D; Michotte, Y; O'Neill, MJ; Ornstein, PL; Ward, MA1

Other Studies

13 other study(ies) available for ly 293558 and 2,3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline

ArticleYear
4,10-Dihydro-4-oxo-4H-imidazo[1,2-a]indeno[1,2-e]pyrazin-2-carboxylic acid derivatives: highly potent and selective AMPA receptors antagonists with in vivo activity.
    Bioorganic & medicinal chemistry letters, 2000, May-15, Volume: 10, Issue:10

    Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Drug Evaluation, Preclinical; Inhibitory Concentration 50; Isoquinolines; Mice; Mice, Inbred DBA; Pyrazines; Quinoxalines; Rats; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Structure-Activity Relationship; Tetrazoles; Urea

2000
Synthesis and potent anticonvulsant activities of 4-oxo-imidazo[1,2-a]inden.
    Bioorganic & medicinal chemistry letters, 2000, Dec-18, Volume: 10, Issue:24

    Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Brain; Cell Membrane; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Administration Routes; Excitatory Amino Acid Agonists; Heterocyclic Compounds, 4 or More Rings; Imidazoles; Inhibitory Concentration 50; Male; Mice; Mice, Inbred DBA; Oocytes; Protein Binding; Pyrazines; Rats; Receptors, AMPA; Seizures; Structure-Activity Relationship; Time Factors; Xenopus

2000
Bioisosteres of 9-carboxymethyl-4-oxo-imidazo[1,2-a]indeno-[1,2-e]pyrazin-2-carboxylic acid derivatives. Progress towards selective, potent in vivo AMPA antagonists with longer durations of action.
    Bioorganic & medicinal chemistry letters, 2001, Jan-22, Volume: 11, Issue:2

    Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Anticonvulsants; Combinatorial Chemistry Techniques; Disease Models, Animal; Excitatory Amino Acid Antagonists; Imidazoles; Inhibitory Concentration 50; Male; Mice; Oocytes; Pyrazinamide; Pyrazines; Receptors, AMPA; Receptors, N-Methyl-D-Aspartate; Seizures; Structure-Activity Relationship

2001
Ethyl (3S,4aR,6S,8aR)-6-(4-ethoxycar- bonylimidazol-1-ylmethyl)decahydroiso-quinoline-3-carboxylic ester: a prodrug of a GluR5 kainate receptor antagonist active in two animal models of acute migraine.
    Journal of medicinal chemistry, 2002, Sep-26, Volume: 45, Issue:20

    Topics: Acute Disease; Administration, Oral; Animals; Biological Availability; Calcium; Carboxylic Acids; Cell Line; Disease Models, Animal; Dose-Response Relationship, Drug; Esters; Excitatory Amino Acid Antagonists; Humans; Isoquinolines; Migraine Disorders; Prodrugs; Radioligand Assay; Rats; Rats, Wistar; Receptors, Kainic Acid

2002
Two prodrugs of potent and selective GluR5 kainate receptor antagonists actives in three animal models of pain.
    Journal of medicinal chemistry, 2005, Jun-30, Volume: 48, Issue:13

    Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Amino Acids; Analgesics; Animals; Biological Availability; Cell Line; Disease Models, Animal; Humans; Hyperalgesia; Pain; Rats; Receptors, AMPA; Receptors, Kainic Acid; Recombinant Proteins; Spinal Cord

2005
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) antagonists: from bench to bedside.
    Journal of medicinal chemistry, 2010, Aug-12, Volume: 53, Issue:15

    Topics: Analgesics; Animals; Anticonvulsants; Antipsychotic Agents; Clinical Trials as Topic; Drug Evaluation, Preclinical; Humans; Neuroprotective Agents; Protein Subunits; Receptors, AMPA

2010
AMPA receptor antagonists and local cerebral glucose utilization in the rat.
    Brain research, 1994, Mar-28, Volume: 641, Issue:1

    Topics: Animals; Autoradiography; Brain; Dose-Response Relationship, Drug; Glucose; Isoquinolines; Male; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Tetrazoles

1994
Pharmacological discrimination of GluR5 and GluR6 kainate receptor subtypes by (3S,4aR,6R,8aR)-6-[2-(1(2)H-tetrazole-5-yl)ethyl]decahyd roisdoquinoline-3 carboxylic-acid.
    Molecular pharmacology, 1996, Volume: 49, Issue:4

    Topics: Animals; Cell Line; Ganglia, Spinal; Humans; Isoquinolines; Purkinje Cells; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, AMPA; Receptors, Kainic Acid; Tetrazoles

1996
Effects of AMPA receptor antagonists on dopamine-mediated behaviors in mice.
    Psychopharmacology, 1998, Volume: 136, Issue:2

    Topics: Animals; Anti-Anxiety Agents; Benzodiazepines; Dopamine; Excitatory Amino Acid Antagonists; Isoquinolines; Male; Mice; Motor Activity; Quinoxalines; Receptors, AMPA; Stereotyped Behavior; Tetrazoles

1998
Kainate GluR5 receptor subtype mediates the nociceptive response to formalin in the rat.
    Neuropharmacology, 1998, Volume: 37, Issue:1

    Topics: Animals; Benzodiazepines; Excitatory Amino Acid Antagonists; Formaldehyde; Humans; Isoquinolines; Male; Pain Threshold; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Kainic Acid; Tetrazoles

1998
Pharmacological characterization of a GluR6 kainate receptor in cultured hippocampal neurons.
    European journal of pharmacology, 1999, Aug-13, Volume: 378, Issue:3

    Topics: alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; Animals; Binding, Competitive; Cell Line; Dose-Response Relationship, Drug; Excitatory Amino Acid Agonists; Excitatory Amino Acid Antagonists; Gene Expression; GluK2 Kainate Receptor; Glutamates; Hippocampus; Humans; Isoquinolines; Kainic Acid; Membrane Potentials; Neurons; Patch-Clamp Techniques; Quinoxalines; Radioligand Assay; Receptors, AMPA; Receptors, Kainic Acid; Recombinant Fusion Proteins; Tetrazoles

1999
LY377770, a novel iGlu5 kainate receptor antagonist with neuroprotective effects in global and focal cerebral ischaemia.
    Neuropharmacology, 2000, Jul-10, Volume: 39, Issue:9

    Topics: Animals; Brain Ischemia; Carotid Stenosis; Cell Death; Dizocilpine Maleate; Excitatory Amino Acid Antagonists; Gerbillinae; Hippocampus; In Situ Nick-End Labeling; Isoquinolines; Male; Microdialysis; Motor Activity; Neuroprotective Agents; Quinoxalines; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Kainic Acid; Tetrazoles

2000
Synthesis of anticonvulsive AMPA antagonists: 4-oxo-10-substituted-imidaz.
    Bioorganic & medicinal chemistry letters, 2001, May-07, Volume: 11, Issue:9

    Topics: Animals; Anticonvulsants; Carboxylic Acids; Dose-Response Relationship, Drug; Electroshock; Injections, Intraperitoneal; Injections, Intravenous; Isoquinolines; Mice; Pyrazines; Quinoxalines; Rats; Receptors, AMPA; Structure-Activity Relationship; Tetrazoles; Xenopus

2001