Page last updated: 2024-09-05

ly 293111 and leukotriene b4

ly 293111 has been researched along with leukotriene b4 in 20 studies

Compound Research Comparison

Studies (ly 293111)	Trials (ly 293111)	Recent Studies (post-2010) (ly 293111)	Studies (leukotriene b4)	Trials (leukotriene b4)	Recent Studies (post-2010) (leukotriene b4)
38	9	6	5,886	232	717

Protein Interaction Comparison

Protein	Taxonomy	ly 293111 (IC50)	leukotriene b4 (IC50)
Leukotriene B4 receptor 1	Homo sapiens (human)		0.0019

Research

Studies (20)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	8 (40.00)	18.2507
2000's	8 (40.00)	29.6817
2010's	4 (20.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Bach, NJ; Baker, SR; Baldwin, RF; Borromeo, PS; Cockerham, SL; Fleisch, JH; Floreancig, P; Froelich, LL; Jackson, WT; Sawyer, JS	1
Froelich, LL; Mann, LL; Marder, P; Sawyer, JS; Spaethe, SM	1
Abbott, DL; Allen, DL; Hoffman, WP; Leiter, PA; Marder, P; Matchett, MR; Wolff, RK	1
Barnes, NC; Christie, PE	1
de Jong, EM; Kuijpers, AL; Marder, P; Mitchell, MI; Spaethe, SM; van de Kerkhof, PC; van Erp, PE; van Hooijdonk, CA; van Pelt, JP	1
Bayley, D; Hill, SL; Llewellyn-Jones, CG; Mikami, M; Stockley, RA	1
Bach, N; Baker, SR; Baldwin, R; Cockerham, SL; Fleisch, JH; Floreancig, P; Froelich, LL; Jackson, WT; Marder, P; Nelson, K; Roman, CR; Saussy, DL; Sawyer, JS; Silbaugh, SA; Sofia, MJ; Spaethe, SM; Stengel, PW	1
Boyd, RJ; Fleisch, JH; Froelich, LL; Goodson, T; Herron, DK; Jackson, WT; Pechous, PA; Roman, CR; Saussy, DL; Sawyer, JS; Schrementi, JP; Schultz, RM; Snyder, DW; Sofia, MJ; Spaethe, SM	1
Kooijmans-Otero, ME; Mommers, JM; Parker, GL; van de Kerkhof, PC; Van Rossum, MM	1
Bendele, AM; Cockerham, SL; Froelich, LL; Jackson, WT; Sawyer, JS; Silbaugh, SA; Sofia, MJ; Spaethe, SM; Stengel, PW	1
Fleisch, JH; Hori, Y; Jyoyama, H; Kuwabara, K; Maruyama, T; Yasui, K	1
Anderskewitz, R; Birke, FW; Jennewein, HM; Meade, CJ; Speck, GA	1
Arimura, A; Asanuma, F; Fleisch, JH; Furue, Y; Hori, Y; Kuwabara, K	1
Adrian, TE; Ding, XZ; Hennig, R; Pour, PM; Standop, J; Tong, WG; Witt, RC	1
Fleisch, JH; Hori, Y; Jyoyama, H; Kuwabara, K	1
Adrian, TE; Bell, RH; Ding, XZ; Talamonti, MS; Tong, WG	1
Brail, L; Enas, N; Eschbach, C; Hirsh, V; Jänne, PA; Oh, Y; Paz-Ares, L; von Pawel, J	1
Beyrau, M; Bodkin, JV; Brohi, K; Chavakis, T; Colom, B; Imhof, BA; Nourshargh, S; Ody, C; Rourke, C; Woodfin, A	1
Hu, C; Liu, X; Mei, YA; Miao, L; Yang, T	1
Chen, C; Dai, J; Han, X; Hu, G; Li, B; Ni, J; Wan, R; Wang, X; Wu, J; Wu, Z; Ye, X	1

Trials

3 trial(s) available for ly 293111 and leukotriene b4

Article	Year
The regulation of CD11b integrin levels on human blood leukocytes and leukotriene B4-stimulated skin by a specific leukotriene B4 receptor antagonist (LY293111). Biochemical pharmacology, 1997, Apr-04, Volume: 53, Issue:7 Topics: Anti-Inflammatory Agents, Non-Steroidal; Benzoates; CD11 Antigens; Flow Cytometry; Humans; Immunohistochemistry; Leukocytes; Leukotriene B4; Male; Receptors, Leukocyte-Adhesion; Receptors, Leukotriene B4; Skin; Up-Regulation	1997
VML 295 (LY-293111), a novel LTB4 antagonist, is not effective in the prevention of relapse in psoriasis. The British journal of dermatology, 2000, Volume: 142, Issue:2 Topics: Administration, Topical; Anti-Inflammatory Agents; Benzoates; Clobetasol; Drug Therapy, Combination; Flow Cytometry; Glucocorticoids; Humans; Leukotriene Antagonists; Leukotriene B4; Psoriasis; Recurrence; Severity of Illness Index	2000
Randomized, double-blind, phase II trial comparing gemcitabine-cisplatin plus the LTB4 antagonist LY293111 versus gemcitabine-cisplatin plus placebo in first-line non-small-cell lung cancer. Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer, 2014, Volume: 9, Issue:1 Topics: Adiponectin; Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Benzoates; Carcinoma, Non-Small-Cell Lung; Cisplatin; Deoxycytidine; Double-Blind Method; Female; Gemcitabine; Humans; Leukotriene B4; Lung Neoplasms; Male; Middle Aged	2014

Other Studies

17 other study(ies) available for ly 293111 and leukotriene b4

Article	Year
Synthetic and structure/activity studies on acid-substituted 2-arylphenols: discovery of 2-[2-propyl-3-[3-[2-ethyl-4-(4-fluorophenyl)-5- hydroxyphenoxy]-propoxy]phenoxy]benzoic acid, a high-affinity leukotriene B4 receptor antagonist. Journal of medicinal chemistry, 1995, Oct-27, Volume: 38, Issue:22 Topics: Airway Obstruction; Animals; Benzoates; Guinea Pigs; Humans; Leukotriene B4; Lung; Neutrophils; Phenols; Receptors, Leukotriene B4; Structure-Activity Relationship; Tetrazoles	1995
Blockade of human neutrophil activation by 2-[2-propyl-3-[3-[2-ethyl-4-(4-fluorophenyl)-5- hydroxyphenoxy]propoxy]phenoxy]benzoic acid (LY293111), a novel leukotriene B4 receptor antagonist. Biochemical pharmacology, 1995, May-26, Volume: 49, Issue:11 Topics: Benzoates; Benzopyrans; Binding, Competitive; Calcium; CD11 Antigens; Dose-Response Relationship, Drug; Humans; Leukotriene B4; Neutrophil Activation; Neutrophils; Receptors, Leukotriene B4; Up-Regulation	1995
The effects of LY293111Na, a leukotriene B4 receptor antagonist, on the pulmonary neutrophilia and CD11b expression caused by inhalation of a leukotriene B4 aerosol in rhesus monkeys. The Journal of pharmacology and experimental therapeutics, 1996, Volume: 277, Issue:1 Topics: Aerosols; Animals; Benzoates; Flow Cytometry; Leukotriene B4; Lung; Macaca mulatta; Macrophage-1 Antigen; Male; Neutrophils; Receptors, Leukotriene B4	1996
Leukotriene B4 and asthma. Thorax, 1996, Volume: 51, Issue:12 Topics: Adult; Animals; Asthma; Benzoates; Child; Child, Preschool; Dogs; Guinea Pigs; Humans; Infant; Leukotriene B4; Lymphokines; Rats; Receptors, Leukotriene B4	1996
The chemotactic activity of sputum from patients with bronchiectasis. American journal of respiratory and critical care medicine, 1998, Volume: 157, Issue:3 Pt 1 Topics: Acute Disease; Anti-Bacterial Agents; Antibodies, Monoclonal; Benzoates; Bronchiectasis; Bronchitis; Cell Movement; Chemotactic Factors; Chemotaxis, Leukocyte; Chronic Disease; Disease Progression; Female; Humans; Interleukin-8; Leukotriene B4; Male; Middle Aged; Mucus; Neutrophils; Receptors, Leukotriene B4; Reproducibility of Results; Sputum; Suppuration	1998
The discovery of LY293111, a novel, potent and orally active leukotriene B4 receptor antagonist of the biphenylphenol class. Advances in experimental medicine and biology, 1997, Volume: 400A Topics: Administration, Oral; Animals; Benzoates; Bronchoconstriction; Cell Membrane; Guinea Pigs; Humans; Leukotriene B4; Lung; Neutrophils; Phenols; Receptors, Leukotriene B4; Structure-Activity Relationship	1997
Pharmacologic actions of the second-generation leukotriene B4 receptor antagonist LY293111: in vitro studies. The Journal of pharmacology and experimental therapeutics, 1999, Volume: 288, Issue:1 Topics: Animals; Benzoates; Binding, Competitive; Cell Aggregation; Cell Membrane; Chemotaxis, Leukocyte; Eicosanoids; Guinea Pigs; Humans; Leukotriene Antagonists; Leukotriene B4; Lung; Male; Neutrophils; Oxidants; Receptors, Leukotriene B4; Spleen; Trachea	1999
Pharmacologic actions of the second generation leukotriene B4 receptor antagonist LY29311: in vivo pulmonary studies. Naunyn-Schmiedeberg's archives of pharmacology, 2000, Volume: 361, Issue:4 Topics: Airway Obstruction; Animals; Benzoates; Benzopyrans; Bronchoalveolar Lavage Fluid; Calcimycin; Chemotaxis, Leukocyte; Dinoprostone; Granulocytes; Guinea Pigs; Inflammation; Leukotriene Antagonists; Leukotriene B4; Lung; Male; Receptors, Leukotriene B4; Thromboxane B2	2000
Effects of the second-generation leukotriene B(4) receptor antagonist, LY293111Na, on leukocyte infiltration and collagen-induced arthritis in mice. European journal of pharmacology, 2000, Aug-25, Volume: 402, Issue:3 Topics: Animals; Arthritis, Experimental; Benzoates; Collagen; Cyclooxygenase Inhibitors; Dinoprostone; Hypersensitivity, Delayed; Interleukin-1; Leukotriene Antagonists; Leukotriene B4; Lipoxygenase Inhibitors; Male; Mice; Mice, Inbred BALB C; Mice, Inbred DBA; Neutrophil Infiltration; Receptors, Leukotriene B4	2000
In vitro and in vivo pharmacological characterization of BIIL 284, a novel and potent leukotriene B(4) receptor antagonist. The Journal of pharmacology and experimental therapeutics, 2001, Volume: 297, Issue:1 Topics: Amidines; Animals; Anti-Inflammatory Agents; Benzoates; Calcium; Carbamates; Cell Line; Chemotaxis, Leukocyte; Guinea Pigs; Humans; Leukotriene B4; Macrophage-1 Antigen; Neutrophils; Rabbits; Rats; Receptors, Leukotriene B4; Species Specificity; Succinates	2001
Effects of leukotriene B4 receptor antagonist, LY293111Na, on antigen-induced bronchial hyperresponsiveness and leukocyte infiltration in sensitized guinea pigs. Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2001, Volume: 50, Issue:3 Topics: Acetylcholine; Animals; Benzoates; Bronchial Hyperreactivity; Bronchoconstriction; Dexamethasone; Guinea Pigs; Leukocytes; Leukotriene Antagonists; Leukotriene B4; Male; Receptors, Leukotriene B4	2001
Leukotriene B4 receptor antagonist LY293111 inhibits proliferation and induces apoptosis in human pancreatic cancer cells. Clinical cancer research : an official journal of the American Association for Cancer Research, 2002, Volume: 8, Issue:10 Topics: Animals; Apoptosis; Benzoates; Blotting, Western; Cell Division; Female; Humans; In Situ Nick-End Labeling; In Vitro Techniques; Leukotriene B4; Mice; Mice, Inbred BALB C; Microscopy, Polarization; Mitogen-Activated Protein Kinase 3; Mitogen-Activated Protein Kinases; Neoplasm Transplantation; Neoplasms, Experimental; Pancreatic Neoplasms; Receptors, Leukotriene B4; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction; Tumor Cells, Cultured	2002
Inhibition of antigen-induced arthritis in guinea pigs by a selective LTB4 receptor antagonist LY293111Na. Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2002, Volume: 51, Issue:11 Topics: Animals; Anti-Inflammatory Agents; Anti-Inflammatory Agents, Non-Steroidal; Arthritis, Experimental; Benzoates; Dexamethasone; Dinoprostone; Female; Guinea Pigs; Indomethacin; Joints; Leukotriene Antagonists; Leukotriene B4; Neutrophil Infiltration; Peroxidase; Rats; Rats, Inbred Lew; Receptors, Leukotriene B4; Serum Albumin, Bovine	2002
LTB4 stimulates growth of human pancreatic cancer cells via MAPK and PI-3 kinase pathways. Biochemical and biophysical research communications, 2005, Sep-30, Volume: 335, Issue:3 Topics: Androstadienes; Arachidonate 5-Lipoxygenase; Benzoates; Butadienes; Cell Division; Cell Line, Tumor; Electrophoresis, Polyacrylamide Gel; Enzyme Inhibitors; Flavonoids; Humans; Leukotriene B4; Mitogen-Activated Protein Kinases; Nitriles; Pancreatic Neoplasms; Phosphatidylinositol 3-Kinases; Phosphoinositide-3 Kinase Inhibitors; Phosphorylation; Signal Transduction; Wortmannin	2005
Leukotriene B4-Neutrophil Elastase Axis Drives Neutrophil Reverse Transendothelial Cell Migration In Vivo. Immunity, 2015, Jun-16, Volume: 42, Issue:6 Topics: Animals; Benzoates; Cell Adhesion Molecules; Cells, Cultured; Endothelial Cells; Humans; Immunoglobulins; Intercellular Junctions; Leukocyte Elastase; Leukotriene B4; Macrophage-1 Antigen; Mice; Mice, Inbred C57BL; Mice, Knockout; Neutrophils; Reperfusion Injury; Transendothelial and Transepithelial Migration; Venules; Wounds and Injuries	2015
Leukotriene B4 Inhibits L-Type Calcium Channels via p38 Signaling Pathway in Vascular Smooth Muscle Cells. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 2015, Volume: 37, Issue:5 Topics: Action Potentials; Animals; Benzoates; Calcium Channels, L-Type; Imidazoles; Leukotriene B4; MAP Kinase Kinase Kinases; Muscle, Smooth, Vascular; p38 Mitogen-Activated Protein Kinases; Patch-Clamp Techniques; Pyridines; Rats; Receptors, Leukotriene B4; RNA, Messenger; Signal Transduction	2015
Substance P-regulated leukotriene B4 production promotes acute pancreatitis-associated lung injury through neutrophil reverse migration. International immunopharmacology, 2018, Volume: 57 Topics: Acinar Cells; Acute Lung Injury; Animals; Benzoates; Cells, Cultured; Ceruletide; Disease Models, Animal; Humans; Leukotriene B4; Male; MAP Kinase Signaling System; Mice; Mice, Inbred BALB C; Neutrophils; Pancreatitis, Acute Necrotizing; Protein Kinase C; Receptors, Leukotriene B4; Receptors, Neurokinin-1; Substance P; Transendothelial and Transepithelial Migration	2018