ly 255283 has been researched along with leukotriene b4 in 31 studies
| Studies (ly 255283) | Trials (ly 255283) | Recent Studies (post-2010) (ly 255283) | Studies (leukotriene b4) | Trials (leukotriene b4) | Recent Studies (post-2010) (leukotriene b4) |
|---|---|---|---|---|---|
| 54 | 0 | 15 | 5,886 | 232 | 717 |
| Protein | Taxonomy | ly 255283 (IC50) | leukotriene b4 (IC50) |
|---|---|---|---|
| Leukotriene B4 receptor 1 | Homo sapiens (human) | 0.0019 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 17 (54.84) | 18.2507 |
| 2000's | 7 (22.58) | 29.6817 |
| 2010's | 6 (19.35) | 24.3611 |
| 2020's | 1 (3.23) | 2.80 |
| Authors | Studies |
|---|---|
| Bach, NJ; Baker, SR; Baldwin, RF; Borromeo, PS; Cockerham, SL; Fleisch, JH; Floreancig, P; Froelich, LL; Jackson, WT; Sawyer, JS | 1 |
| Cho, AE; Choi, Y; Goo, JI; Harmalkar, DS; Kim, JH; Kim, M; Lee, K; Wei, JD | 1 |
| Bollinger, NG; Froelich, LL; Goodson, T; Herron, DK; Jackson, WT; Staten, GS; Swanson-Bean, D; Thompson, AR; Wright, IG | 1 |
| Rola-Pleszczynski, M; Stanková, J | 1 |
| Grisham, MB; Keenan, CM; Vaananen, PM; Wallace, JL | 1 |
| Herron, DK; Marder, P; Schultz, RM; Sofia, MJ; Spaethe, SM | 2 |
| Donigi-Gale, D; Edwards, R; Norman, KE; Rossi, AG; Shoupe, TS; Williams, TJ | 1 |
| Cockerham, SL; Fleisch, JH; Goodson, T; Herron, DK; Roman, CR; Saussy, DL; Silbaugh, SA; Spaethe, SM; Stengel, PW | 1 |
| Guo, JP; Karasawa, A; Lefer, AM; Ma, XL; Tsao, PS | 1 |
| Johnson, RA; Richards, IM; Shields, SK; Smith, HW | 1 |
| Hahn, RA; MacDonald, BR; Parli, CJ; Potts, BD; Simpson, PJ | 1 |
| Nixon, AB; O'Flaherty, JT; Wijkander, J; Wykle, RL | 1 |
| Fink, MP; Fleisch, JH; Menconi, MJ; O'Sullivan, BP; Wang, H; Wollert, PS; Youssef, ME | 1 |
| Cordes, J; O'Flaherty, JT; Redman, J; Thomas, MJ | 1 |
| Gravel, S; Hashefi, M; MacLeod, RJ; Mills, E; Powell, WS | 1 |
| Baker, JR; Bigby, TD; Riddick, CA; Ring, WL; Serio, KJ | 1 |
| Giembycz, MA; Hellewell, PG; Lindsay, MA; Teixeira, MM | 1 |
| Harris, J; Rola-Pleszczynski, M; Stankova, J; Turcotte, S | 1 |
| Ji, X; Kurahashi, K; Nishihashi, T; Trandafir, CC; Wang, A | 1 |
| Haeggström, JZ; Johansson, AS; Palmblad, J; Qiu, H; Schröder, O; Sjöström, M; Wan, M | 1 |
| Bae, YS; Lee, HY; Shin, EH | 1 |
| Anderson, R; Steel, HC; Theron, AJ; Tintinger, GR | 1 |
| Cho, SH; Kim, GY; Kim, JH; Lee, JW; Seo, JM | 1 |
| Ba, X; Cui, L; Sun, R; Xue, Y; Zeng, X | 1 |
| Choi, JA; Kim, EY; Kim, H; Kim, JH; Ko, J; Lee, JW; Seo, JM | 1 |
| Chung, JH; Kim, C; Kim, JH; Kim, JY; Ryu, HC | 1 |
| Kim, C; Kim, EY; Kim, JH; Lee, JE; Lee, KM; Seo, JM | 1 |
| Kim, KA; Kim, SH; Lee, YA; Min, A; Nam, YH; Shin, MH; Song, KJ | 1 |
| Brown, CR; Olson, RM; Zhang, Y | 1 |
| Jang, JH; Kim, JH; Park, J | 1 |
31 other study(ies) available for ly 255283 and leukotriene b4
| Article | Year |
|---|---|
Synthetic and structure/activity studies on acid-substituted 2-arylphenols: discovery of 2-[2-propyl-3-[3-[2-ethyl-4-(4-fluorophenyl)-5- hydroxyphenoxy]-propoxy]phenoxy]benzoic acid, a high-affinity leukotriene B4 receptor antagonist.
Topics: Airway Obstruction; Animals; Benzoates; Guinea Pigs; Humans; Leukotriene B4; Lung; Neutrophils; Phenols; Receptors, Leukotriene B4; Structure-Activity Relationship; Tetrazoles | 1995 |
Elucidation of Mechanism for Ligand Efficacy at Leukotriene B
Topics: | 2020 |
Leukotriene B4 receptor antagonists: the LY255283 series of hydroxyacetophenones.
Topics: Acetophenones; Humans; Leukotriene B4; Magnetic Resonance Spectroscopy; Neutrophils; Receptors, Immunologic; Receptors, Leukotriene B4; Structure-Activity Relationship; Tetrazoles | 1992 |
Leukotriene B4 enhances interleukin-6 (IL-6) production and IL-6 messenger RNA accumulation in human monocytes in vitro: transcriptional and posttranscriptional mechanisms.
Topics: Cells, Cultured; Cycloheximide; Dactinomycin; Genistein; Humans; Interleukin-6; Isoflavones; Kinetics; Leukotriene B4; Monocytes; Protein Biosynthesis; Protein-Tyrosine Kinases; RNA, Messenger; Signal Transduction; Tetrazoles; Transcription, Genetic | 1992 |
Pharmacological investigation of the role of leukotrienes in the pathogenesis of experimental NSAID gastropathy.
Topics: 5-Lipoxygenase-Activating Proteins; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Benzopyrans; Carrier Proteins; Free Radical Scavengers; Gastric Mucosa; Hydroxyurea; Indoles; Indomethacin; Leukotriene Antagonists; Leukotriene B4; Leukotrienes; Lipoxygenase Inhibitors; Male; Masoprocol; Membrane Proteins; Organic Chemicals; Permeability; Phenylcarbamates; Propionates; Quinolines; Rats; Rats, Inbred Strains; Receptors, Immunologic; Receptors, Leukotriene; Receptors, Leukotriene B4; Single-Blind Method; Stomach Ulcer; Sulfonamides; Tetrazoles; Tosyl Compounds | 1992 |
Flow cytometric evaluation of the effects of leukotriene B4 receptor antagonists (LY255283 and SC-41930) on calcium mobilization and integrin expression of activated human neutrophils.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Benzopyrans; Calcium; Cells, Cultured; Dose-Response Relationship, Drug; Flow Cytometry; Humans; Integrins; Leukotriene B4; Neutrophils; Receptors, Immunologic; Receptors, Leukotriene B4; Tetrazoles; Up-Regulation | 1992 |
The role of complement, platelet-activating factor and leukotriene B4 in a reversed passive Arthus reaction.
Topics: Animals; Arthus Reaction; Azepines; Complement System Proteins; Edema; Isoquinolines; Leukotriene B4; Platelet Activating Factor; Rabbits; Radioimmunoassay; Receptors, Complement; Tetrazoles; Triazoles; Zymosan | 1992 |
Pulmonary actions of LY255283, a leukotriene B4 receptor antagonist.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Airway Obstruction; Analgesics; Animals; Dinoprostone; Guinea Pigs; In Vitro Techniques; Leukotriene B4; Lung; Lung Volume Measurements; Male; Membranes; Muscle Contraction; Prostaglandin Endoperoxides, Synthetic; Pulmonary Gas Exchange; Radioligand Assay; Receptors, Immunologic; Receptors, Leukotriene B4; Tetrazoles; Thromboxane A2 | 1992 |
Protective actions of a leukotriene B4 antagonist in splanchnic ischemia and reperfusion in rats.
Topics: Animals; Arteries; Blood Pressure; Cathepsin D; Constriction; Endothelium, Vascular; Ileum; Ischemia; Leukotriene B4; Male; Neutrophils; Peroxidase; Rats; Rats, Inbred Strains; Reperfusion; Splanchnic Circulation; Tetrazoles | 1991 |
Effects of two leukotriene B4 (LTB4) receptor antagonists (LY255283 and SC-41930) on LTB4-induced human neutrophil adhesion and superoxide production.
Topics: Adult; Benzopyrans; Cell Adhesion; Humans; In Vitro Techniques; Leukotriene B4; Neutrophils; Receptors, Immunologic; Receptors, Leukotriene B4; Superoxides; Tetrazoles | 1991 |
Effect of the selective leukotriene B4 antagonists U-75302 and Ly255283 on bronchoalveolar eosinophilia induced by inhalation of leukotriene B4 or allergen in brown-Norway rats.
Topics: Allergens; Animals; Bronchi; Eosinophilia; Fatty Alcohols; Glycols; Leukotriene B4; Lung; Pulmonary Alveoli; Rats; Rats, Inbred BN; Tetrazoles | 1991 |
Antagonism of leukotriene B4 receptors does not limit canine myocardial infarct size.
Topics: Animals; Azoles; Blood Pressure; Coronary Circulation; Dogs; Heart Rate; Leukopenia; Leukotriene B4; Male; Myocardial Infarction; Neutrophils; Receptors, Immunologic; Receptors, Leukotriene B4; SRS-A; Tetrazoles | 1990 |
5-Lipoxygenase products modulate the activity of the 85-kDa phospholipase A2 in human neutrophils.
Topics: 5,8,11,14-Eicosatetraynoic Acid; alpha-Linolenic Acid; Arachidonate 5-Lipoxygenase; Arachidonic Acid; Arachidonic Acids; Cytosol; Enzyme Activation; Exocytosis; Humans; Hydroxyeicosatetraenoic Acids; Kinetics; Leukotriene B4; Molecular Weight; N-Formylmethionine Leucyl-Phenylalanine; Neutrophils; Phospholipases A; Phospholipases A2; Tetrazoles | 1995 |
A novel leukotriene B4-receptor antagonist in endotoxin shock: a prospective, controlled trial in a porcine model.
Topics: 6-Ketoprostaglandin F1 alpha; Animals; Bronchoalveolar Lavage Fluid; Disease Models, Animal; Drug Evaluation, Preclinical; Escherichia coli Infections; Extravascular Lung Water; Hemodynamics; Leukotriene B4; Male; Peroxidase; Proteins; Random Allocation; Respiratory Distress Syndrome; Shock, Septic; Swine; Tetrazoles; Thromboxane B2 | 1993 |
5-Oxo-eicosatetraenoate, a potent human neutrophil stimulus.
Topics: Arachidonic Acids; Calcium; Cell Degranulation; Cells, Cultured; Humans; Hydroxyeicosatetraenoic Acids; In Vitro Techniques; Leukotriene B4; Neutrophils; Tetrazoles | 1993 |
Stimulation of human neutrophils by 5-oxo-6,8,11,14-eicosatetraenoic acid by a mechanism independent of the leukotriene B4 receptor.
Topics: Arachidonic Acids; Calcium; Cytosol; Eicosanoids; Humans; In Vitro Techniques; Kinetics; Leukotriene B4; Neutrophils; Receptors, Immunologic; Receptors, Leukotriene B4; Tetrazoles; Time Factors | 1993 |
Leukotriene B4 costimulates 5-lipoxygenase activity in neutrophils via increased 5-lipoxygenase translocation.
Topics: Arachidonate 5-Lipoxygenase; Arachidonic Acid; Biological Transport; Cell Count; Cell Membrane; Humans; Leukotriene B4; Neutrophils; Receptors, Leukotriene B4; Tetrazoles | 1997 |
Role of arachidonic acid in leukotriene B(4)-induced guinea-pig eosinophil homotypic aggregation.
Topics: Animals; Arachidonic Acid; Calcium; Cell Aggregation; Dose-Response Relationship, Drug; Eosinophils; Female; Guinea Pigs; Leukotriene Antagonists; Leukotriene B4; Lipoxygenase Inhibitors; Male; Phospholipases A; Pyrans; Quinacrine; Quinolones; Tetradecanoylphorbol Acetate; Tetrazoles | 1999 |
Modulation of leukotriene B4 receptor-1 expression by dexamethasone: potential mechanism for enhanced neutrophil survival.
Topics: Adjuvants, Immunologic; Calcium; Cell Survival; Dactinomycin; Dexamethasone; Fatty Alcohols; Flow Cytometry; Glycols; Half-Life; Humans; Intracellular Fluid; Leukotriene B4; Neutrophils; Receptors, Leukotriene B4; RNA, Messenger; Tetrazoles; Transcription, Genetic; Up-Regulation | 2002 |
Cysteinyl leukotrienes and leukotriene B mediate vasoconstriction to arginine vasopressin in rat basilar artery.
Topics: Animals; Arginine Vasopressin; Basilar Artery; Benzopyrans; Carboxylic Acids; Female; In Vitro Techniques; Leukotriene Antagonists; Leukotriene B4; Leukotriene C4; Leukotriene D4; Lipoxygenase Inhibitors; Muscle, Smooth, Vascular; Propionates; Quinolines; Rats; Rats, Sprague-Dawley; Receptors, Leukotriene; Receptors, Leukotriene B4; Tetrazoles; Vasoconstriction; Vasoconstrictor Agents | 2005 |
Differential induction of BLT receptor expression on human endothelial cells by lipopolysaccharide, cytokines, and leukotriene B4.
Topics: Calcium; Cells, Cultured; Chemokine CCL2; Endothelial Cells; Humans; Interleukin-1; Leukotriene Antagonists; Leukotriene B4; Lipopolysaccharides; Nitrites; Protein Isoforms; Receptors, Leukotriene B4; Receptors, Purinergic P2; Signal Transduction; Tetrazoles; Tumor Necrosis Factor-alpha | 2006 |
Leukotriene B4 stimulates human monocyte-derived dendritic cell chemotaxis.
Topics: Calcium; Cells, Cultured; Chemotaxis, Leukocyte; Dendritic Cells; Extracellular Signal-Regulated MAP Kinases; GTP-Binding Proteins; Humans; Leukotriene B4; Monocytes; Pertussis Toxin; Phosphatidylinositol 3-Kinases; Receptors, Leukotriene B4; Receptors, Purinergic P2; Tetrazoles | 2006 |
Itraconazole-mediated inhibition of calcium entry into platelet-activating factor-stimulated human neutrophils is due to interference with production of leukotriene B4.
Topics: Adenosine Triphosphate; Antifungal Agents; Calcium; Cells, Cultured; Cytosol; Dose-Response Relationship, Drug; Humans; Indoles; Itraconazole; Leukotriene Antagonists; Leukotriene B4; Lipoxygenase Inhibitors; Neutrophil Activation; Neutrophils; Platelet Activating Factor; Spectrometry, Fluorescence; Tetrazoles | 2007 |
Role of the low-affinity leukotriene B4 receptor BLT2 in VEGF-induced angiogenesis.
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Animals; Arachidonate 12-Lipoxygenase; Cell Movement; Cells, Cultured; Endothelial Cells; Humans; Leukotriene Antagonists; Leukotriene B4; Ligands; Mice; Mice, Transgenic; Neovascularization, Physiologic; Receptors, Leukotriene B4; RNA Interference; RNA, Messenger; RNA, Small Interfering; Tetrazoles; Up-Regulation; Vascular Endothelial Growth Factor A | 2009 |
Leukotriene B4 regulates proliferation and differentiation of cultured rat myoblasts via the BLT1 pathway.
Topics: Animals; Cell Differentiation; Cell Growth Processes; Cells, Cultured; Fatty Alcohols; Fluorescent Antibody Technique; Glycols; Leukotriene Antagonists; Leukotriene B4; Myoblasts; Rats; Receptors, Leukotriene B4; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Satellite Cells, Skeletal Muscle; Signal Transduction; Tetrazoles | 2009 |
Pro-survival of estrogen receptor-negative breast cancer cells is regulated by a BLT2-reactive oxygen species-linked signaling pathway.
Topics: Breast Neoplasms; Cells, Cultured; Female; Humans; Leukotriene B4; NADPH Oxidase 1; NADPH Oxidases; Reactive Oxygen Species; Receptors, Estrogen; Receptors, Leukotriene B4; Signal Transduction; Tetrazoles | 2010 |
UVB radiation induces apoptosis in keratinocytes by activating a pathway linked to "BLT2-reactive oxygen species".
Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Animals; Apoptosis; Cell Line, Transformed; Epidermis; Humans; Keratinocytes; Leukotriene Antagonists; Leukotriene B4; Male; MAP Kinase Signaling System; Membrane Potential, Mitochondrial; Mice; Mice, Inbred Strains; Mice, Transgenic; NADPH Oxidase 1; NADPH Oxidases; Reactive Oxygen Species; Receptors, Leukotriene B4; Tetrazoles; Ultraviolet Rays | 2010 |
BLT2 promotes the invasion and metastasis of aggressive bladder cancer cells through a reactive oxygen species-linked pathway.
Topics: Animals; Carcinoma; Cell Line, Tumor; Humans; Leukotriene B4; Lung Neoplasms; Mice; Mice, Nude; NADPH Oxidase 1; NADPH Oxidase 4; NADPH Oxidases; Neoplasm Invasiveness; Neoplasm Staging; Neoplasm Transplantation; NF-kappa B; Prognosis; Reactive Oxygen Species; Receptors, Leukotriene B4; RNA, Small Interfering; Signal Transduction; Tetrazoles; Transcriptional Activation; Urinary Bladder Neoplasms | 2010 |
Leukotriene B(4) receptors BLT1 and BLT2 are involved in interleukin-8 production in human neutrophils induced by Trichomonas vaginalis-derived secretory products.
Topics: Benzoquinones; Endopeptidase K; Fatty Alcohols; Glycols; Hot Temperature; Humans; Interleukin-8; Leukotriene Antagonists; Leukotriene B4; Lipase; Lipoxygenase Inhibitors; Neutrophil Activation; Neutrophils; Piperazines; Receptors, Leukotriene B4; Tetrazoles; Thiazoles; Trichomonas Infections; Trichomonas vaginalis | 2012 |
Macrophage LTB
Topics: Animals; Arachidonate 5-Lipoxygenase; Borrelia burgdorferi; Disease Models, Animal; Humans; Leukotriene B4; Lyme Disease; Macrophages; Mice; Mice, Transgenic; Phagocytosis; Receptors, Leukotriene B4; Tetrazoles | 2017 |
Mediatory role of BLT2 in the proliferation of KRAS mutant colorectal cancer cells.
Topics: Animals; Cell Line, Tumor; Cell Movement; Cell Proliferation; Colorectal Neoplasms; Female; Humans; Hydroxyeicosatetraenoic Acids; Leukotriene B4; Mice; Mice, Inbred BALB C; Mice, Nude; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins p21(ras); Receptors, Leukotriene B4; Signal Transduction; Tetrazoles; Up-Regulation; Xenograft Model Antitumor Assays | 2019 |