Page last updated: 2024-09-03

ly 243670 and naltrexone

ly 243670 has been researched along with naltrexone in 4 studies

Compound Research Comparison

Studies
(ly 243670)
Trials
(ly 243670)
Recent Studies (post-2010)
(ly 243670)
Studies
(naltrexone)
Trials
(naltrexone)
Recent Studies (post-2010) (naltrexone)
14028,7451,2282,642

Protein Interaction Comparison

ProteinTaxonomyly 243670 (IC50)naltrexone (IC50)
Cytochrome P450 2D6Homo sapiens (human)1
Delta-type opioid receptorMus musculus (house mouse)0.0051
Delta-type opioid receptorRattus norvegicus (Norway rat)0.0063
Kappa-type opioid receptorMus musculus (house mouse)0.006
Mu-type opioid receptorRattus norvegicus (Norway rat)0.0005
Kappa-type opioid receptorRattus norvegicus (Norway rat)0.0005
Mu-type opioid receptorHomo sapiens (human)0.006
Delta-type opioid receptorHomo sapiens (human)0.0319
Kappa-type opioid receptorCavia porcellus (domestic guinea pig)0.0093
Kappa-type opioid receptorHomo sapiens (human)0.0377
Mu-type opioid receptorMus musculus (house mouse)0.0076
Mu-type opioid receptorCavia porcellus (domestic guinea pig)0.0004

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (25.00)18.2507
2000's2 (50.00)29.6817
2010's1 (25.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Shaw, WN1
Emmerson, PJ; McKinzie, JH; Mitch, CH; Statnick, MA; Surface, PL; Suter, TM1
Gackenheimer, SL; Gehlert, DR; Mitch, CH; Pintar, JE; Quimby, SJ; Statnick, MA; Suter, TM; Wheeler, WJ1
Bell, RL; Dhaher, R; Hauser, SR; McBride, WJ; McKinzie, DL; Rodd, ZA; Toalston, JE1

Other Studies

4 other study(ies) available for ly 243670 and naltrexone

ArticleYear
Long-term treatment of obese Zucker rats with LY255582 and other appetite suppressants.
    Pharmacology, biochemistry, and behavior, 1993, Volume: 46, Issue:3

    Topics: Albuterol; Animals; Appetite Depressants; Cyclohexanes; Dextroamphetamine; Drug Tolerance; Eating; Endorphins; Female; Fenfluramine; Injections, Subcutaneous; Male; Naltrexone; Obesity; Piperidines; Rats; Rats, Zucker; Weight Gain

1993
Na+ modulation, inverse agonism, and anorectic potency of 4-phenylpiperidine opioid antagonists.
    European journal of pharmacology, 2004, Jun-28, Volume: 494, Issue:2-3

    Topics: Animals; Appetite Depressants; Binding, Competitive; Cell Membrane; CHO Cells; Cricetinae; Cyclohexanes; Diprenorphine; Dose-Response Relationship, Drug; Eating; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Guanosine 5'-O-(3-Thiotriphosphate); Ligands; Naltrexone; Narcotic Antagonists; Piperidines; Radioligand Assay; Rats; Rats, Zucker; Receptors, Opioid; Receptors, Opioid, delta; Sodium

2004
Localization of opioid receptor antagonist [3H]-LY255582 binding sites in mouse brain: comparison with the distribution of mu, delta and kappa binding sites.
    Neuropeptides, 2005, Volume: 39, Issue:6

    Topics: Animals; Autoradiography; Binding Sites; Brain; Cyclohexanes; Mice; Mice, Knockout; Molecular Structure; Naloxone; Naltrexone; Narcotic Antagonists; Piperidines; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Tritium

2005
Effects of naltrexone and LY255582 on ethanol maintenance, seeking, and relapse responding by alcohol-preferring (P) rats.
    Alcohol (Fayetteville, N.Y.), 2012, Volume: 46, Issue:1

    Topics: Alcohol Drinking; Animals; Central Nervous System Depressants; Conditioning, Operant; Cyclohexanes; Drug-Seeking Behavior; Ethanol; Extinction, Psychological; Female; Naltrexone; Narcotic Antagonists; Piperidines; Rats; Secondary Prevention

2012