ly-2140023 has been researched along with eglumetad* in 1 studies
1 other study(ies) available for ly-2140023 and eglumetad
| Article | Year |
|---|---|
Discovery of 1,5-disubstituted pyridones: a new class of positive allosteric modulators of the metabotropic glutamate 2 receptor.
A series of 1,5-disubstituted pyridones was identified as positive allosteric modulators (PAMs) of the metabotropic glutamate receptor 2 (mGluR2) via high throughput screening (HTS). Subsequent SAR exploration led to the identification of several compounds with improved in vitro activity. Lead compound 8 was further profiled and found to attenuate the increase in PCP induced locomotor activity in mice. Topics: Allosteric Regulation; Amino Acids; Animals; Bridged Bicyclo Compounds; Drug Evaluation, Preclinical; Drug Stability; Excitatory Amino Acid Agonists; Humans; Hydrophobic and Hydrophilic Interactions; Mice; Molecular Structure; Motor Activity; Pyridines; Pyridones; Receptors, Metabotropic Glutamate; Recombinant Proteins; Structure-Activity Relationship; Sulfonamides | 2010 |