ly 186126 has been researched along with indolidan in 5 studies
| Studies (ly 186126) | Trials (ly 186126) | Recent Studies (post-2010) (ly 186126) | Studies (indolidan) | Trials (indolidan) | Recent Studies (post-2010) (indolidan) |
|---|---|---|---|---|---|
| 7 | 0 | 0 | 25 | 1 | 0 |
| Protein | Taxonomy | ly 186126 (IC50) | indolidan (IC50) |
|---|---|---|---|
| cAMP-specific 3',5'-cyclic phosphodiesterase 4A | Homo sapiens (human) | 0.15 | |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4B | Homo sapiens (human) | 0.15 | |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4C | Homo sapiens (human) | 0.15 | |
| cAMP-specific 3',5'-cyclic phosphodiesterase 4D | Homo sapiens (human) | 0.15 | |
| cGMP-inhibited 3',5'-cyclic phosphodiesterase B | Homo sapiens (human) | 3.54 | |
| cGMP-inhibited 3',5'-cyclic phosphodiesterase A | Homo sapiens (human) | 3.54 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (80.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Artman, M; Mahony, L; Robertson, DW; Thompson, WJ | 1 |
| Kauffman, RF; Robertson, DW; Utterback, BG | 2 |
| Kauffman, RF; Krushinski, JH; Robertson, DW; Utterback, BG | 1 |
| Beaudry, C; Le Bec, A; Lugnier, C; Muller, B; Rousseau, E | 1 |
5 other study(ies) available for ly 186126 and indolidan
| Article | Year |
|---|---|
Analysis of the binding sites for the cardiotonic phosphodiesterase inhibitor [3H]LY186126 in ventricular myocardium.
Topics: Animals; Binding Sites; Cardiotonic Agents; Edetic Acid; Heart Ventricles; Indoles; Magnesium; Magnesium Chloride; Oxindoles; Phosphodiesterase Inhibitors; Pyridazines; Rabbits; Sarcoplasmic Reticulum; Sheep | 1989 |
Specific binding of [3H]LY186126, an analogue of indolidan (LY195115), to cardiac membranes enriched in sarcoplasmic reticulum vesicles.
Topics: Animals; Binding Sites; Cardiotonic Agents; Dogs; Indoles; Microsomes; Myocardium; Oxindoles; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pyridazines; Sarcoplasmic Reticulum; Tritium | 1989 |
Characterization and pharmacological relevance of high affinity binding sites for [3H]LY186126, a cardiotonic phosphodiesterase inhibitor, in canine cardiac membranes.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Binding Sites; Cardiotonic Agents; Cyclic GMP; Dogs; Enzyme Activation; Hydrogen-Ion Concentration; Indoles; Ions; Membranes; Myocardium; Oxindoles; Phosphodiesterase Inhibitors; Pyridazines; Sarcoplasmic Reticulum | 1989 |
Synthesis of a tritium-labeled indolidan analogue and its use as a radioligand for phosphodiesterase-inhibitor cardiotonic binding sites.
Topics: Animals; Binding Sites; Chemical Phenomena; Chemistry; Dogs; Female; Indoles; Ligands; Male; Myocardium; Oxindoles; Phosphodiesterase Inhibitors; Pyridazines; Radioligand Assay; Spectrophotometry, Ultraviolet; Tritium | 1989 |
Characterization of indolidan- and rolipram-sensitive cyclic nucleotide phosphodiesterases in canine and human cardiac microsomal fractions.
Topics: 3',5'-Cyclic-AMP Phosphodiesterases; Animals; Cardiotonic Agents; Chromatography, High Pressure Liquid; Dogs; Humans; In Vitro Techniques; Indoles; Intracellular Membranes; Kinetics; Microsomes; Myocardium; Oxindoles; Phosphodiesterase Inhibitors; Phosphoric Diester Hydrolases; Pyridazines; Pyrrolidinones; Rolipram; Sarcoplasmic Reticulum | 1993 |