ly 134046 has been researched along with 7,8-dichloro-1,2,3,4-tetrahydroisoquinoline in 16 studies
| Studies (ly 134046) | Trials (ly 134046) | Recent Studies (post-2010) (ly 134046) | Studies (7,8-dichloro-1,2,3,4-tetrahydroisoquinoline) | Trials (7,8-dichloro-1,2,3,4-tetrahydroisoquinoline) | Recent Studies (post-2010) (7,8-dichloro-1,2,3,4-tetrahydroisoquinoline) |
|---|---|---|---|---|---|
| 31 | 0 | 0 | 79 | 0 | 0 |
| Protein | Taxonomy | ly 134046 (IC50) | 7,8-dichloro-1,2,3,4-tetrahydroisoquinoline (IC50) |
|---|---|---|---|
| Phenylethanolamine N-methyltransferase | Homo sapiens (human) | 2.5057 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (37.50) | 18.7374 |
| 1990's | 5 (31.25) | 18.2507 |
| 2000's | 5 (31.25) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Caldwell, TM; Criscione, KR; Dahanukar, VH; Grunewald, GL; Jalluri, RK | 1 |
| Caldwell, TM; Criscione, KR; Grunewald, GL; Li, Q | 2 |
| Borchardt, RT; Caldwell, TM; Criscione, KR; Grunewald, GL; Li, Q; Slavica, M; Wang, W | 1 |
| Criscione, KR; Grunewald, GL; McLeish, MJ | 1 |
| Archbold, J; Caine, JM; Criscione, KR; Grunewald, GL; Martin, JL; McLeish, MJ; McMillan, FM | 1 |
| Criscione, KR; Grunewald, GL; McLeish, MJ; Wu, Q | 1 |
| Gee, CL; Grunewald, GL; Lin, F; Martin, JL; McLeish, MJ; Tyndall, JD; Wu, Q | 1 |
| Antunes-Rodrigues, J; Cobas, C; de-Castro-e-Silva, E; Fregoneze, JB; Machado, A; Midlej, M; Nonaka, KO; Ramalho, MJ | 1 |
| Linnoila, M; Lister, RG; Mefford, IN; Ota, M | 1 |
| Coen, CW; Gallo, RV | 1 |
| Guchhait, RB; Perry, BD; Stolk, JM; U'Prichard, DC; Vantini, G | 1 |
| Fuller, RW; Hemrick-Luecke, S; Horng, JS; Molloy, BB; Ruffolo, RR; Toomey, RE | 1 |
| Franz, DN; Sangdee, C | 1 |
| Biollaz, B; Biollaz, J; Bresnahan, M; Gavras, H; Gavras, I; Kohlman, O | 1 |
| Fuller, RW; Hemrick-Luecke, SK | 1 |
16 other study(ies) available for ly 134046 and 7,8-dichloro-1,2,3,4-tetrahydroisoquinoline
| Article | Year |
|---|---|
Comparative molecular field analysis (CoMFA) models of phenylethanolamine N-methyltransferase (PNMT) and the alpha2-adrenoceptor: the development of new, highly selective inhibitors of PNMT.
Topics: Enzyme Inhibitors; Models, Chemical; Phenylethanolamine N-Methyltransferase; Receptors, Adrenergic, alpha-2; Structure-Activity Relationship | 1999 |
Synthesis and evaluation of 3-trifluoromethyl-7-substituted-1,2,3, 4-tetrahydroisoquinolines as selective inhibitors of phenylethanolamine N-methyltransferase versus the alpha(2)-adrenoceptor.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Cattle; Cerebral Cortex; Clonidine; Enzyme Inhibitors; In Vitro Techniques; Isoquinolines; Male; Phenylethanolamine N-Methyltransferase; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Structure-Activity Relationship; Tetrahydroisoquinolines | 1999 |
Synthesis and biochemical evaluation of 3-fluoromethyl-1,2,3, 4-tetrahydroisoquinolines as selective inhibitors of phenylethanolamine N-methyltransferase versus the alpha(2)-adrenoceptor.
Topics: Adrenal Glands; Adrenergic alpha-2 Receptor Antagonists; Animals; Binding, Competitive; Blood-Brain Barrier; Cattle; Clonidine; Enzyme Inhibitors; Fluorine Compounds; Isoquinolines; Models, Molecular; Permeability; Phenylethanolamine N-Methyltransferase | 1999 |
Phenylethanolamine N-methyltransferase kinetics: bovine versus recombinant human enzyme.
Topics: Animals; Cattle; Epinephrine; Humans; Kinetics; Models, Molecular; Phenylethanolamine N-Methyltransferase; Recombinant Proteins; Stereoisomerism; Structure-Activity Relationship; Substrate Specificity | 2001 |
Synthesis and evaluation of 4-fluoro-8-substituted-2,3,4,5-tetrahydro-1H-2-benzazapines as selective inhibitors of phenylethanolamine N-methyltransferase versus the alpha(2)-adrenoceptor.
Topics: Adrenergic alpha-Antagonists; Animals; Benzazepines; Cerebral Cortex; Clonidine; Enzyme Inhibitors; In Vitro Techniques; Male; Models, Molecular; Phentolamine; Phenylethanolamine N-Methyltransferase; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-2; Structure-Activity Relationship | 2001 |
Molecular recognition of sub-micromolar inhibitors by the epinephrine-synthesizing enzyme phenylethanolamine N-methyltransferase.
Topics: Benzazepines; Binding Sites; Crystallography, X-Ray; Epinephrine; Humans; Isoquinolines; Models, Molecular; Phenylethanolamine N-Methyltransferase; Protein Binding; Quinolines; S-Adenosylhomocysteine; Substrate Specificity | 2004 |
Phenylethanolamine N-methyltransferase inhibition: re-evaluation of kinetic data.
Topics: Enzyme Inhibitors; Kinetics; Phenylethanolamine N-Methyltransferase | 2004 |
Structural, mutagenic, and kinetic analysis of the binding of substrates and inhibitors of human phenylethanolamine N-methyltransferase.
Topics: 2-Hydroxyphenethylamine; Binding Sites; Catalysis; Crystallography, X-Ray; Humans; Kinetics; Models, Molecular; Mutation; Phenylethanolamine N-Methyltransferase; Protein Binding; S-Adenosylhomocysteine; S-Adenosylmethionine; Tetrahydroisoquinolines | 2005 |
Effects of central epinephrine synthesis inhibition on stress-induced prolactin secretion in male rats.
Topics: Albuterol; Animals; Benzazepines; Epinephrine; Injections, Intraventricular; Isoquinolines; Male; Monoamine Oxidase Inhibitors; Prolactin; Rats; Rats, Inbred Strains; Stress, Physiological; Tetrahydroisoquinolines | 1991 |
Antagonism of ethanol intoxication in rats by inhibitors of phenylethanolamine N-methyltransferase.
Topics: Alcoholic Intoxication; Animals; Benzazepines; Benzylamines; Diazepam; Isoquinolines; Male; Pentobarbital; Phenylethanolamine N-Methyltransferase; Rats; Rats, Inbred Strains; Tetrahydroisoquinolines | 1990 |
Effects of various inhibitors of phenylethanolamine N-methyltransferase on pulsatile release of LH in ovariectomized rats.
Topics: Animals; Benzazepines; Dopamine; Epinephrine; Female; Hypothalamus; Isoquinolines; Luteinizing Hormone; Norepinephrine; Ovariectomy; Phenylethanolamine N-Methyltransferase; Rats; Rats, Inbred Strains; Tetrahydroisoquinolines | 1986 |
Assessment of the functional role of brain adrenergic neurons: chronic effects of phenylethanolamine N-methyltransferase inhibitors and alpha adrenergic receptor antagonists on brain norepinephrine metabolism.
Topics: Adrenergic alpha-Antagonists; Animals; Benzazepines; Brain; Female; Isoquinolines; Norepinephrine; Phenylethanolamine N-Methyltransferase; Prazosin; Rats; Rats, Inbred F344; Tetrahydroisoquinolines; Tissue Distribution; Tyrosine 3-Monooxygenase; Yohimbine | 1984 |
Properties of 8,9-dichloro-2,3,4,5-tetrahydro-1H-2-benzazepine, an inhibitor of norepinephrine N-methyltransferase.
Topics: Adrenal Glands; Animals; Aorta, Thoracic; Benzazepines; Benzylamines; Brain; In Vitro Techniques; Isoquinolines; Male; Muscle Contraction; Phenylethanolamine N-Methyltransferase; Rabbits; Rats; Receptors, Adrenergic, alpha; Tetrahydroisoquinolines | 1981 |
Evidence for inhibition of sympathetic preganglionic neurons by bulbospinal epinephrine pathways.
Topics: Adrenergic Fibers; Animals; Autonomic Fibers, Preganglionic; Benzazepines; Cats; Dose-Response Relationship, Drug; Epinephrine; Evoked Potentials; Ganglia, Sympathetic; Isoquinolines; Norepinephrine; Phenylethanolamine N-Methyltransferase; Reflex; Spinal Cord; Synaptic Transmission; Tetrahydroisoquinolines | 1983 |
Acute cardiovascular effects of two central phenylethanolamine-N-methyl-transferase inhibitors in unanesthetized desoxycorticosterone-salt hypertensive rats.
Topics: Animals; Benzazepines; Blood Pressure; Brain; Desoxycorticosterone; Heart Rate; Hemodynamics; Hypertension; Isoquinolines; Male; Phenylethanolamine N-Methyltransferase; Rats; Rats, Inbred Strains; Tetrahydroisoquinolines | 1984 |
Comparison of some conformationally rigid benzylamine analogs as substrates for rabbit lung N-methyltransferase.
Topics: Amines; Animals; Benzazepines; Benzylamines; In Vitro Techniques; Isoquinolines; Kinetics; Lung; Methyltransferases; Molecular Conformation; Rabbits; Serotonin; Tetrahydroisoquinolines; Tryptamines | 1980 |