Page last updated: 2024-08-26

ly 117018 and thiophenes

ly 117018 has been researched along with thiophenes in 99 studies

Research

Studies (99)

Timeframe	Studies, this research(%)	All Research%
pre-1990	35 (35.35)	18.7374
1990's	31 (31.31)	18.2507
2000's	31 (31.31)	29.6817
2010's	2 (2.02)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Carlson, KE; Katzenellenbogen, JA; Pinney, KG	1
Best, KL; Goode, RL; Heiman, ML; Hoover, DM; Merriman, RL; Neubauer, BL; Robertson, DW; Sarosdy, MF; Shaar, CJ; Tanzer, LR	1
Ballejo, G; Gong, Y; Murphy, LC; Murphy, LJ	1
Koga, M; Sutherland, RL	2
Hagino, Y; Kohno, K; Kuwano, M; Mizoguchi, H; Uchiumi, T	1
Curtis, SW; Korach, KS	1
Katzenellenbogen, BS; Keith, D; Read, LD; Slamon, DJ	1
Braunsberg, H; Coldham, NG; Patel, K	1
Durani, N; Durani, S; Jain, R; Kapil, RS; Saeed, A; Sharma, AP	1
Durani, S; Kapil, RS; Saeed, A; Sharma, AP	1
Arnold, AP; Mathews, GA	1
Boundy, V; Komm, BS; Lyttle, CR; Sundstrom, SA; Xu, Q	1
Galman, MS; Lyttle, CR; Sundstrom, SA	1
Davidson, NE; Gelmann, EP; Kasid, A; Lippman, ME	1
Hölzel, F; May, FE; Westley, BR	1
Dickson, RB; Katz, D; Lippman, ME; Shima, TB; Thompson, EW; Wakeling, AE	1
Johnson, MD; Kastner, P; May, FE; Wakeling, AE; Westley, BR; Wiseman, LR	1
Cheville, A; Freter, CE; Gelmann, EP; Lippman, ME; Zinn, S	1
Katzenellenbogen, BS; Toney, TW	1
Giambiagi, N; Pasqualini, JR; Sumida, C	1
May, FE; Westley, BR	1
Crastes de Paulet, A; Cypriani, B; Descomps, B; Tabacik, C	1
Lyttle, CR; Teuscher, C; Zheng, Y; Zhou, ZZ	1
Dey, SK; Huet, YM	1
Heimberg, M; Weinstein, I	1
Shimizu, S; Takeda, A	1
Bronzert, DA; Davidson, N; Lippman, M	1
Amara, JF; Dannies, PS	1
Henry, EC; Miller, RK	1
Amara, JF; Dannies, PS; Martinez-Campos, A	1
Donahoe, PK; Hutson, JM; MacLaughlin, DT	1
Campen, CA; Gorski, J; Jordan, VC	1
Finch, CE; Gordon, MN; Mobbs, CV	1
Bronzert, DA; Greene, GL; Lippman, ME	1
Gelmann, EP; Kasid, A; Lippman, ME; Lowy, DR; Papageorge, AG	1
Jordan, VC	1
Green, LR; Newboult, E; Valcaccia, B; Wakeling, AE	1
Newboult, E; O'Connor, KM; Wakeling, AE	1
Valcaccia, B; Wakeling, AE	1
Gosden, B; Jordan, VC	2
Jordan, VC; Mueller, GC; Olsen, MR; Tate, AC; Van Oosbree, TR	1
Huff, KK; Lippman, ME; Scholl, SM	1
Keeping, HS; Lyttle, CR	1
Black, LJ; Goode, RL; Jones, CD	1
Black, LJ; Goode, RL	2
Benvenuti, S; Brandi, ML; Falchetti, A; Fiorelli, G; Frediani, U; Gori, F; Masi, L; Morelli, AM	1
Borras, M; Bouhoute, A; Jin, L; Leclercq, G; Legros, N	1
Ma, ZQ; Maggi, A; Patrone, C; Pollio, G; Santagati, S; Vegeto, E	1
Berthois, Y; Crastes de Paulet, A; Dussert, C; Martin, PM; Pons, M	1
Anstead, GM; Katzenellenbogen, JA; Kym, PR; Pinney, KG; Wilson, SR	1
Cattaneo, E; Conti, E; Ma, ZQ; Maggi, A; Pollio, G; Santagati, S; Spreafico, E	1
Katzenellenbogen, BS; Kraus, WL	1
Bowman, AR; Epstein, S; Jee, WS; Liang, H; Ma, YF; Marshall, I; Sass, DA	1
Apelgren, LD; Bailey, DL; Bryan, N; Bumol, TF; Evans, GF; Fouts, RL; Glasebrook, A; Sandusky, GE; Short, L; Zuckerman, SH	1
Bryan, N; Zuckerman, SH	1
Dube, G; Laher, I; Rahimian, R; van Breemen, C	1
Calero, JA; Curiel, MD; de la Piedra, C; Gala, J; Gazapo, R; Guerrero, R	1
Arad, Y; Rattan, AK	1
Inoue, T; Kushida, K; Li, X; Takahashi, M	1
De Caterina, R; Genazzani, AR; Simoncini, T	1
Bryant, H; Drost, D; Fraher, LJ; Hock, J; Hodsman, AB; Holdsworth, D; Thornton, M; Watson, PH	2
Bernardi, F; Genazzani, AD; Genazzani, AR; Giardina, L; Luisi, M; Luisi, S; Monteleone, P; Petraglia, F; Rubino, S; Stomati, M	1
Essmann, M; Larsen, B	1
Benayahu, D; Graff, E; Liu, Z	1
Acharya, A; Lei, J; Neugarten, J; Silbiger, S	1
Berg, DT; Calnek, DS; Ciaccia, AV; Grinnell, BW; Joyce, DE; Richardson, MA	1
Bernardi, F; Casarosa, E; Farzati, A; Genazzani, AR; Luisi, M; Luisi, S; Monteleone, P; Petraglia, F; Rubino, S; Stomati, M	1
Carlsten, H; Erlandsson, MC; Gömöri, E; Taube, M	1
Dolphin, PJ; Dubé, PJ; McKendrick, JD; Radomski, MW; Russell, JC	1
Aguilar, R; Bellido, C; Garrido-Gracia, JC; Gonzalez, D; Sánchez-Criado, JE	1
Bentrem, D; Dardes, RC; De Los Reyes, A; Jordan, VC; Lee, ES; O'Regan, RM; Schafer, JM	1
Adachi, K; Hayakawa, J; Hisamoto, K; Kanda, Y; Mabuchi, S; Miyamoto, Y; Murata, Y; Nishio, Y; Ohmichi, M; Takahashi, K; Taniguchi, N; Tasaka, K	1
Bramlett, KS; Burris, TP	1
Aguilar, R; Bellido, C; Garrido-Gracia, JC; Sánchez-Criado, JE	1
Carlsten, H; Erlandsson, MC; Jonsson, CA; Lindberg, MK; Ohlsson, C	1
Alonso, C; Borges, R; Machado, JD; Morales, A	1
Alonso, R; Bellido, C; Glidewell-Kenney, C; Guelmes, P; Hernández, G; Hernández-Jiménez, JG; López, FJ; Marín, F; Martínez-Morales, JR; Prieto, L; Sánchez-Criado, JE	1
Islamov, R; McMurray, R; Murashov, AK	1
Balaguer, P; Bonnet, S; Cavaillès, V; Duong, V; Escande, A; Margueron, R; Vignon, F	1
Barone, G; Bollati, A; Bonfanti, C; Burattin, A; Cozzi, R; Giustina, A; Poiesi, C; Tulipano, G; Turazzi, S; Valle, D	1
Alvarez, L; Catalán, MP; De la Piedra, C; García-Moreno, C; Ortiz, A	1
Levine, L	1
Body, JJ; Journé, F; Laurent, G; Leclercq, G; Nonclercq, D	1
Aknin, C; Chalbos, D; Freiss, G; Galtier, F; Maudelonde, T; Puech, C; Vignon, F	1
Chin, WW; Dantzig, AH; Iversen, PW; Jin, S; Krishnan, V; Lesoon, A; Moore, RE; O'Brien, KA; Peek, VL; Perry, WL; Rolfe, M; Sampath, J; Shepard, RL; Shyjan, A; Tighe, M; Williamson, M; Yaden, B	1
Benjamins, JA; Deighton-Collins, S; Guzmán, CB; Kleerekoper, M; Martinez, A; Skafar, DF; Zhao, C	1
Clarke, R; Dai, P; Lou, MA; Lu, JF; Nazarov, V; Wong, LJ	1
Collishaw, S; Huber, C; Mosley, JR; Noble, BS; Reeve, J	1
Carlsten, H; Islander, U; Jochems, C; Kallkopf, A; Lagerquist, M; Ohlsson, C	1
Kudo, Y; Nobuzane, T; Tashiro, S	1
Akishita, M; Eto, M; Kozaki, K; Okabe, T; Ouchi, Y; Yu, J	1
Akishita, M; Eto, M; Okabe, T; Ouchi, Y; Yu, J	1
Carlsten, H; Engdahl, C; Gustafsson, JA; Jochems, C; Lagerquist, MK; van der Saag, PT	1
Abe, Y; Irie, T; Iwasaki, N; Komatsu, M; Majima, T; Minami, A; Takahata, M	1
Brosch, S; Brozek, W; Gruber, R; Hofbauer, G; Lernbass, I; Pietschmann, P; Wutzl, A	1

Reviews

4 review(s) available for ly 117018 and thiophenes

Article	Year
Pharmacodynamic and biological effects of anti-estrogens in different models. Journal of steroid biochemistry, 1988, Volume: 31, Issue:4B Topics: Animals; Antibodies, Monoclonal; Cell Division; Clomiphene; DNA-Binding Proteins; Estradiol; Estrogen Antagonists; Female; Growth Substances; Humans; Lipoproteins, LDL; Liver; Nafoxidine; Nitromifene; Polyunsaturated Alkamides; Pyrrolidines; Receptors, Estrogen; Receptors, Progesterone; Species Specificity; Structure-Activity Relationship; Tamoxifen; Thiophenes; Uterus	1988
Estrogen and antiestrogen resistance in human breast cancer cell lines. Advances in experimental medicine and biology, 1986, Volume: 196 Topics: Breast Neoplasms; Cell Division; Cell Line; Diethylstilbestrol; Drug Resistance; Estradiol; Estrogen Antagonists; Estrogens; Female; Glycoproteins; Humans; Molecular Weight; Pyrrolidines; Tamoxifen; Thiophenes; Time Factors	1986
Laboratory studies to develop general principles for the adjuvant treatment of breast cancer with antiestrogens: problems and potential for future clinical applications. Breast cancer research and treatment, 1983, Volume: 3 Suppl Topics: 9,10-Dimethyl-1,2-benzanthracene; Animals; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Combined Modality Therapy; Disease Models, Animal; Dose-Response Relationship, Drug; Estrogen Antagonists; Female; Half-Life; Humans; Mammary Neoplasms, Experimental; Models, Biological; Piperidines; Pyrrolidines; Raloxifene Hydrochloride; Rats; Rats, Inbred Strains; Receptors, Estrogen; Tamoxifen; Thiophenes	1983
A novel nongenomic action of estrogens: the regulation of exocytotic kinetics. Annals of the New York Academy of Sciences, 2002, Volume: 971 Topics: Animals; Catecholamines; Cattle; Chromaffin Cells; Cyclic AMP; Estradiol; Estrogens; Exocytosis; Kinetics; Pyrrolidines; Rats; Selective Estrogen Receptor Modulators; Thiophenes; Time Factors	2002

Other Studies

95 other study(ies) available for ly 117018 and thiophenes

Article	Year
Nonsteroidal estrogens bearing acyl azide functions: potential electrophilic and photoaffinity labeling agents for the estrogen receptor. Steroids, 1992, Volume: 57, Issue:5 Topics: Affinity Labels; Animals; Azides; Cytosol; Electrochemistry; Estrogen Antagonists; Female; Molecular Conformation; Molecular Structure; Photochemistry; Pyrrolidines; Rats; Receptors, Estrogen; Sheep; Tetrahydronaphthalenes; Thiophenes; Uterus	1992
Comparative antitumor effects of hormonal ablation, estrogen agonist, estrogen cytotoxic derivative, and antiestrogen in the PAIII rat prostatic adenocarcinoma. Cancer research, 1992, Sep-01, Volume: 52, Issue:17 Topics: Adenocarcinoma; Adrenal Glands; Animals; Aromatase Inhibitors; Body Weight; Chlorobenzenes; Estradiol; Estramustine; Hypophysectomy; Male; Neoplasm Metastasis; Neoplasms, Experimental; Orchiectomy; Organ Size; Prostatic Neoplasms; Pyrimidines; Pyrrolidines; Rats; Rats, Inbred Strains; Seminal Vesicles; Testis; Thiophenes	1992
Differential effects of estrogen and antiestrogen on transforming growth factor gene expression in endometrial adenocarcinoma cells. Cancer research, 1992, Apr-01, Volume: 52, Issue:7 Topics: Adenocarcinoma; Analysis of Variance; Cell Division; Cell Line; Dose-Response Relationship, Drug; Endometrial Neoplasms; ErbB Receptors; Estradiol; Estrogen Antagonists; Female; Gene Expression; Humans; Kinetics; Polyunsaturated Alkamides; Pyrrolidines; RNA, Messenger; Tamoxifen; Thiophenes; Transforming Growth Factor alpha; Tumor Cells, Cultured	1992
Retinoic acid acts synergistically with 1,25-dihydroxyvitamin D3 or antioestrogen to inhibit T-47D human breast cancer cell proliferation. The Journal of steroid biochemistry and molecular biology, 1991, Volume: 39, Issue:4A Topics: Breast Neoplasms; Calcitriol; Cell Division; Cell Line; Clomiphene; Drug Synergism; Estradiol; Estrogen Antagonists; Female; Humans; Kinetics; Pyrrolidines; Receptors, Calcitriol; Receptors, Estradiol; Receptors, Steroid; Tamoxifen; Thiophenes; Tretinoin	1991
Counteraction of estradiol-induced activation of tissue-type plasminogen activator in a human breast cancer cell line by an anti-estrogen, LY117018. International journal of cancer, 1991, Jan-02, Volume: 47, Issue:1 Topics: Breast Neoplasms; Cell Division; Cell Line; Colony-Forming Units Assay; Dose-Response Relationship, Drug; Enzyme-Linked Immunosorbent Assay; Estradiol; Estrogen Antagonists; Gene Expression Regulation, Neoplastic; Humans; In Vitro Techniques; Pyrrolidines; Receptors, Estrogen; RNA; Tamoxifen; Thiophenes; Tissue Plasminogen Activator	1991
Uterine estrogen receptor-DNA complexes: effects of different ERE sequences, ligands, and receptor forms. Molecular endocrinology (Baltimore, Md.), 1991, Volume: 5, Issue:7 Topics: Animals; Cell Nucleus; DNA; Estradiol; Estrogen Antagonists; Estrogens; Female; Gene Expression Regulation; Kinetics; Mice; Pyrrolidines; Receptors, Estrogen; Regulatory Sequences, Nucleic Acid; Thiophenes; Uterus; Vitellogenins	1991
Hormonal modulation of HER-2/neu protooncogene messenger ribonucleic acid and p185 protein expression in human breast cancer cell lines. Cancer research, 1990, Jul-01, Volume: 50, Issue:13 Topics: Breast Neoplasms; Estrogen Antagonists; Estrogens; Humans; Mifepristone; Neoplasms, Hormone-Dependent; Progestins; Prognosis; Promegestone; Proto-Oncogene Proteins; Pyrrolidines; Receptor, ErbB-2; RNA, Messenger; RNA, Neoplasm; Thiophenes; Tumor Cells, Cultured	1990
Hormone and cytotoxic drug responsiveness of cultured human breast cancer cells resistant to specific hormones. International journal of cancer, 1990, Apr-15, Volume: 45, Issue:4 Topics: Breast Neoplasms; Cell Division; Dexamethasone; Drug Resistance; Estradiol; Humans; Medroxyprogesterone; Medroxyprogesterone Acetate; Methotrexate; Pyrrolidines; Tamoxifen; Thiophenes; Tumor Cells, Cultured; Vincristine	1990
Structure-activity relationship of antiestrogens. Studies on 2,3-diaryl-1-benzopyrans. Journal of medicinal chemistry, 1990, Volume: 33, Issue:12 Topics: Animals; Benzopyrans; Biological Assay; Chemical Phenomena; Chemistry; Cytosol; Estrogen Antagonists; Female; Molecular Structure; Organ Size; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Estrogen; Structure-Activity Relationship; Tamoxifen; Thiophenes; Uterus	1990
Structure-activity relationship of antiestrogens. Effect of the side chain and its position on the activity of 2,3-diaryl-2H-1-benzopyrans. Journal of medicinal chemistry, 1990, Volume: 33, Issue:12 Topics: Animals; Benzopyrans; Binding, Competitive; Chemical Phenomena; Chemistry; Cytosol; Estrogen Antagonists; Female; Mice; Microsomes, Liver; Molecular Structure; Organ Size; Piperidines; Pyrrolidines; Rats; Receptors, Estrogen; Structure-Activity Relationship; Tamoxifen; Thiophenes; Uterus	1990
Antiestrogens fail to prevent the masculine ontogeny of the zebra finch song system. General and comparative endocrinology, 1990, Volume: 80, Issue:1 Topics: Animals; Birds; Brain; Estrogen Antagonists; Female; Male; Pyrrolidines; Sex Differentiation; Stilbenes; Tamoxifen; Thiophenes; Vocalization, Animal	1990
The stimulation of uterine complement component C3 gene expression by antiestrogens. Endocrinology, 1990, Volume: 126, Issue:3 Topics: Animals; Complement C3; Drug Interactions; Drug Synergism; Estradiol; Estrogen Antagonists; Female; Gene Expression Regulation; Kinetics; Nucleic Acid Hybridization; Piperidines; Progesterone; Pyrrolidines; Raloxifene Hydrochloride; Rats; Rats, Inbred Strains; RNA, Messenger; Tamoxifen; Thiophenes; Uterus	1990
Antagonism of estrogen- and antiestrogen-induced uterine complement component C3 expression by ICI 164,384. Journal of steroid biochemistry, 1990, Jul-04, Volume: 36, Issue:4 Topics: Animals; Complement C3; Epithelial Cells; Estradiol; Estrogen Antagonists; Female; Organ Size; Polyunsaturated Alkamides; Pyrrolidines; Rats; Rats, Inbred Strains; RNA, Messenger; Tamoxifen; Thiophenes; Uterus	1990
Transcriptional control of thymidine kinase gene expression by estrogen and antiestrogens in MCF-7 human breast cancer cells. The Journal of biological chemistry, 1986, Apr-25, Volume: 261, Issue:12 Topics: Amanitins; Breast Neoplasms; Cell Cycle; Cell Line; DNA; Estradiol; Estrogen Antagonists; Estrogens; Gene Expression Regulation; Humans; Methylation; Pyrrolidines; RNA; RNA, Messenger; Tamoxifen; Thiophenes; Thymidine; Thymidine Kinase; Time Factors	1986
Effects of oestrogen and the antioestrogens, tamoxifen and LY117018, on four oestrogen-regulated RNAs in the EFM-19 breast cancer cell line. Journal of steroid biochemistry, 1989, Volume: 32, Issue:3 Topics: Breast Neoplasms; Dose-Response Relationship, Drug; Estradiol; Estrogen Antagonists; Gene Expression Regulation; Humans; Nucleic Acid Hybridization; Pyrrolidines; Receptors, Estrogen; RNA; RNA, Messenger; Tamoxifen; Thiophenes; Tumor Cells, Cultured	1989
ICI 164,384, a pure antagonist of estrogen-stimulated MCF-7 cell proliferation and invasiveness. Cancer research, 1989, Dec-15, Volume: 49, Issue:24 Pt 1 Topics: Basement Membrane; Binding, Competitive; Breast Neoplasms; Cell Cycle; Estradiol; Estrogen Antagonists; Humans; Neoplasm Invasiveness; Polyunsaturated Alkamides; Pyrrolidines; Receptors, Estrogen; Stimulation, Chemical; Tamoxifen; Thiophenes; Tumor Cells, Cultured	1989
Regulation of progesterone receptor mRNA by oestradiol and antioestrogens in breast cancer cell lines. Journal of steroid biochemistry, 1989, Volume: 33, Issue:6 Topics: Animals; Autoradiography; Blotting, Northern; Electrophoresis, Polyacrylamide Gel; Estradiol; Estrogen Antagonists; Mammary Neoplasms, Experimental; Polyunsaturated Alkamides; Pyrrolidines; Receptors, Progesterone; RNA, Messenger; Tamoxifen; Thiophenes; Tumor Cells, Cultured	1989
Alterations in phosphoinositide metabolism associated with 17 beta-estradiol and growth factor treatment of MCF-7 breast cancer cells. Molecular endocrinology (Baltimore, Md.), 1988, Volume: 2, Issue:2 Topics: Breast Neoplasms; Estradiol; Female; Growth Substances; Humans; Phosphatidylinositols; Pyrrolidines; Thiophenes; Tumor Cells, Cultured	1988
An evaluation of the interactions of antiestrogens with pituitary and striatal dopamine receptors. Journal of receptor research, 1987, Volume: 7, Issue:5 Topics: Animals; Binding, Competitive; Cell Membrane; Corpus Striatum; Diethylamines; Estrogen Antagonists; Female; Nitromifene; Pituitary Gland, Anterior; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Dopamine; Receptors, Dopamine D2; Spiperone; Tamoxifen; Thiophenes	1987
Oestrogen regulates oestrogen receptor mRNA levels in an oestrogen-responsive human breast cancer cell line. Biochemical and biophysical research communications, 1988, Sep-30, Volume: 155, Issue:3 Topics: Breast Neoplasms; Cell Line; Estradiol; Female; Humans; Pyrrolidines; Receptors, Estrogen; RNA, Messenger; Thiophenes	1988
Role of estrogen receptors and antiestrogen binding sites in an early effect of antiestrogens, the inhibition of cholesterol biosynthesis. Journal of steroid biochemistry, 1988, Volume: 31, Issue:5 Topics: Animals; Binding Sites; Cell Division; Cell Line; Cholesterol; Humans; Molecular Weight; Pyrrolidines; Rats; Receptors, Drug; Receptors, Estrogen; Tamoxifen; Thiophenes; Tumor Cells, Cultured	1988
Immunohistochemical characterization of the estrogen-stimulated leukocyte influx in the immature rat uterus. Journal of leukocyte biology, 1988, Volume: 44, Issue:1 Topics: Animals; Antigens, Differentiation, T-Lymphocyte; Cell Movement; Estrogens; Female; Histocompatibility Antigens Class II; Immunohistochemistry; Leukocytes; Pertussis Toxin; Pyrrolidines; Rats; Rats, Inbred Strains; Thiophenes; Uterus; Virulence Factors, Bordetella	1988
Role of early and late oestrogenic effects on implantation in the mouse. Journal of reproduction and fertility, 1987, Volume: 81, Issue:2 Topics: Animals; Clomiphene; Embryo Implantation; Embryo Implantation, Delayed; Estradiol; Estriol; Estrogens; Female; Mice; Mice, Inbred Strains; Nafoxidine; Nitromifene; Organ Size; Ovariectomy; Progesterone; Pyrrolidines; Tamoxifen; Thiophenes; Uterus	1987
Effects of the antiestrogen LY 117018 on the modulation by ethinyl estradiol of the metabolism of [1-14C]oleic acid by perfused livers from normal and ovariectomized rats. Biochemical pharmacology, 1988, Jan-15, Volume: 37, Issue:2 Topics: Animals; Body Weight; Carbon Radioisotopes; Cholesterol Esters; Estrogen Antagonists; Ethinyl Estradiol; Female; Ketone Bodies; Kinetics; Liver; Oleic Acid; Oleic Acids; Organ Size; Ovariectomy; Perfusion; Pyrrolidines; Rats; Rats, Inbred Strains; Reference Values; Thiophenes; Triglycerides	1988
Molecular effects of antiestrogens (tamoxifen and LY117018) on estrogen-dependent glycoprotein (USP-1) synthesized and secreted by rat uterine epithelial cells. Endocrinology, 1988, Volume: 123, Issue:1 Topics: Animals; Epithelium; Estradiol; Estrogen Antagonists; Female; Kinetics; Neoplasm Proteins; Ovariectomy; Pyrrolidines; Rats; Rats, Inbred Strains; Reference Values; Tamoxifen; Thiophenes; Uterus	1988
Epidermal growth factor partially reverses the inhibitory effects of antiestrogens on T 47D human breast cancer cell growth. Biochemical and biophysical research communications, 1987, Jul-31, Volume: 146, Issue:2 Topics: Breast Neoplasms; Cell Division; Cell Line; Clomiphene; Epidermal Growth Factor; Estrogen Antagonists; Humans; Pyrrolidines; Tamoxifen; Thiophenes	1987
Characterization of antiestrogen stimulation of cell number and prolactin production. Molecular and cellular endocrinology, 1986, Volume: 47, Issue:3 Topics: Cell Cycle; Cell Line; Estradiol; Pituitary Gland; Prolactin; Pyrrolidines; Tamoxifen; Thiophenes	1986
The antiestrogen LY117018 is estrogenic in the fetal rat. Teratology, 1986, Volume: 34, Issue:1 Topics: Abnormalities, Drug-Induced; Animals; Binding, Competitive; Diethylstilbestrol; Estradiol; Estrogen Antagonists; Female; Fetus; Pregnancy; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Estrogen; Teratogens; Thiophenes	1986
Antiestrogens are partial estrogen agonists for prolactin production in primary pituitary cultures. Molecular and cellular endocrinology, 1986, Volume: 48, Issue:2-3 Topics: Animals; Cells, Cultured; Estradiol; Estrogen Antagonists; Kinetics; Male; Pituitary Gland, Anterior; Prolactin; Pyrrolidines; Rats; Rats, Inbred Strains; Tamoxifen; Thiophenes	1986
Steroid modulation of Mullerian duct regression in the chick embryo. General and comparative endocrinology, 1985, Volume: 57, Issue:1 Topics: Aminoglutethimide; Androstenedione; Animals; Anti-Mullerian Hormone; Chick Embryo; Drug Interactions; Estrogen Antagonists; Estrogens; Female; Glycoproteins; Growth Inhibitors; Male; Mullerian Ducts; Norethindrone; Pyrrolidines; Tamoxifen; Testicular Hormones; Thiophenes	1985
Opposing biological actions of antiestrogens in vitro and in vivo: induction of progesterone receptor in the rat and mouse uterus. Endocrinology, 1985, Volume: 116, Issue:6 Topics: Animals; Cells, Cultured; Estradiol; Estrogen Antagonists; Female; In Vitro Techniques; Mice; Mice, Inbred ICR; Pyrrolidines; Rats; Receptors, Progesterone; Species Specificity; Stereoisomerism; Structure-Activity Relationship; Tamoxifen; Thiophenes; Uterus	1985
The antiestrogen LY117018 blocks effects of estradiol on pituitary glucose-6-phosphate dehydrogenase specific activity and on serum LH. Neuroendocrinology, 1985, Volume: 40, Issue:5 Topics: Animals; Castration; Estradiol; Estrogen Antagonists; Feedback; Female; Glucosephosphate Dehydrogenase; Luteinizing Hormone; Mice; Mice, Inbred C57BL; Organ Size; Pituitary Gland; Pyrrolidines; Thiophenes; Uterus	1985
Selection and characterization of a breast cancer cell line resistant to the antiestrogen LY 117018. Endocrinology, 1985, Volume: 117, Issue:4 Topics: Binding, Competitive; Breast Neoplasms; Cell Division; Cell Line; Drug Resistance; Estradiol; Female; Humans; Molecular Weight; Phenotype; Pyrrolidines; Receptors, Estrogen; Receptors, Progesterone; Tamoxifen; Thiophenes	1985
Transfection of v-rasH DNA into MCF-7 human breast cancer cells bypasses dependence on estrogen for tumorigenicity. Science (New York, N.Y.), 1985, May-10, Volume: 228, Issue:4700 Topics: Animals; Breast Neoplasms; Cell Line; Cell Transformation, Neoplastic; DNA, Neoplasm; Estrogens; Female; Humans; Mice; Mice, Nude; Neoplasms, Experimental; Oncogenes; Pyrrolidines; Repetitive Sequences, Nucleic Acid; Thiophenes; Transfection	1985
Non-steroidal antioestrogens--receptor binding and biological response in rat uterus, rat mammary carcinoma and human breast cancer cells. Journal of steroid biochemistry, 1984, Volume: 20, Issue:1 Topics: Animals; Breast Neoplasms; Cell Line; Estrogen Antagonists; Female; Humans; Mammary Neoplasms, Experimental; Piperidines; Pyrrolidines; Raloxifene Hydrochloride; Rats; Receptors, Estrogen; Tamoxifen; Thiophenes; Uterus	1984
Comparison of the biological effects of tamoxifen and a new antioestrogen (LY 117018) on the immature rat uterus. The Journal of endocrinology, 1983, Volume: 99, Issue:3 Topics: Animals; Estradiol; Estrogen Antagonists; Female; Organ Size; Pyrrolidines; Rats; Rats, Inbred Strains; Sexual Maturation; Tamoxifen; Thiophenes; Uterus	1983
Antioestrogenic and antitumour activities of a series of non-steroidal antioestrogens. The Journal of endocrinology, 1983, Volume: 99, Issue:3 Topics: Animals; Estradiol; Estrogen Antagonists; Female; Mammary Neoplasms, Experimental; Organ Size; Piperidines; Pyrrolidines; Raloxifene Hydrochloride; Rats; Rats, Inbred Strains; Tamoxifen; Thiophenes; Uterus	1983
Differential antiestrogen action in the immature rat uterus: a comparison of hydroxylated antiestrogens with high affinity for the estrogen receptor. Journal of steroid biochemistry, 1983, Volume: 19, Issue:3 Topics: Animals; Binding, Competitive; Estrogen Antagonists; Female; Kinetics; Organ Size; Promegestone; Pyrrolidines; Rats; Rats, Inbred Strains; Receptors, Estrogen; Sexual Maturation; Tamoxifen; Thiophenes; Uterus	1983
An immobilized antiestrogen binds a specific uterine protein in addition to estrogen receptor proteins. Molecular and cellular endocrinology, 1984, Volume: 35, Issue:2-3 Topics: Agar; Animals; Carrier Proteins; Cytosol; Estrogen Antagonists; Female; Molecular Weight; Pyrrolidines; Rats; Receptors, Estrogen; Tamoxifen; Thiophenes; Uterus	1984
Inhibition of the uterotropic activity of estrogens and antiestrogens by the short acting antiestrogen LY117018. Endocrinology, 1983, Volume: 113, Issue:2 Topics: Animals; Castration; Estradiol; Estrogen Antagonists; Female; Mice; Organ Size; Pyrrolidines; Rats; Rats, Inbred Strains; Structure-Activity Relationship; Tamoxifen; Thiophenes; Uterus	1983
Antiestrogenic effects of LY 117018 in MCF-7 cells. Endocrinology, 1983, Volume: 113, Issue:2 Topics: Binding, Competitive; Breast Neoplasms; Cell Division; Cell Line; DNA Replication; Estradiol; Estrogen Antagonists; Female; Humans; Kinetics; Pyrrolidines; Receptors, Estrogen; Receptors, Progesterone; Tamoxifen; Thiophenes	1983
Modulation of rat uterine progesterone receptor levels and peroxidase activity by tamoxifen citrate, LY117018, and estradiol. Endocrinology, 1982, Volume: 111, Issue:6 Topics: Animals; Cytosol; Estradiol; Female; Organ Size; Peroxidases; Progesterone; Promegestone; Pyrrolidines; Rats; Receptors, Progesterone; Tamoxifen; Thiophenes; Uterus	1982
Differential interaction of antiestrogens with cytosol estrogen receptors. Molecular and cellular endocrinology, 1981, Volume: 22, Issue:1 Topics: Animals; Binding, Competitive; Cytosol; Estradiol; Estrogen Antagonists; Female; Pyrrolidines; Rats; Receptors, Estrogen; Tamoxifen; Temperature; Thiophenes; Uterus	1981
Evidence for biological action of the antiestrogens LY117018 and tamoxifen by different mechanisms. Endocrinology, 1981, Volume: 109, Issue:3 Topics: Animals; Castration; Estradiol; Estrogen Antagonists; Female; Pyrrolidines; Rats; Receptors, Estradiol; Receptors, Estrogen; Structure-Activity Relationship; Tamoxifen; Thiophenes; Uterus	1981
Uterine bioassay of tamoxifen, trioxifene and a new estrogen antagonist (LY117018) in rats and mice. Life sciences, 1980, Apr-28, Volume: 26, Issue:17 Topics: Aging; Animals; Biological Assay; Castration; Dose-Response Relationship, Drug; Estradiol; Estrogen Antagonists; Female; Mice; Pyrrolidines; Rats; Species Specificity; Tamoxifen; Thiophenes; Uterus	1980
Evidence for bioeffects of LY 139478 on the human pre-osteoclastic cell line FLG 29.1. Biochemical and biophysical research communications, 1995, Jun-26, Volume: 211, Issue:3 Topics: Bone Marrow Cells; Calcitonin; Cell Division; Cell Line; Cyclic AMP; DNA Damage; Dose-Response Relationship, Drug; Drug Interactions; Estradiol; Estrogen Antagonists; Filaggrin Proteins; Humans; Interleukin-6; Osteoclasts; Pyrrolidines; Stem Cells; Thiophenes	1995
Evaluation of estrogen receptor, antiestrogen binding sites and calmodulin for antiestrogen resistance of two clones derived from the MCF-7 breast cancer cell line. Biochemical pharmacology, 1994, Nov-29, Volume: 48, Issue:11 Topics: Binding Sites; Calmodulin; Cell Division; Clone Cells; Drug Resistance; Estrogen Antagonists; Humans; Imidazoles; Pyrrolidines; Receptors, Estrogen; Receptors, Progesterone; Tamoxifen; Thiophenes; Tumor Cells, Cultured	1994
Insulin-like growth factors activate estrogen receptor to control the growth and differentiation of the human neuroblastoma cell line SK-ER3. Molecular endocrinology (Baltimore, Md.), 1994, Volume: 8, Issue:7 Topics: Animals; Brain; Cell Differentiation; Cell Division; Estradiol; Estrogens; Fulvestrant; Gene Expression Regulation, Neoplastic; Humans; Insulin-Like Growth Factor I; Insulin-Like Growth Factor II; Models, Neurological; Morphogenesis; Neoplasm Proteins; Neuroblastoma; Neurons; Pyrrolidines; Rats; Receptors, Estrogen; Recombinant Fusion Proteins; Thiophenes; Transfection; Tumor Cells, Cultured	1994
Agonist-antagonist activity of anti-estrogens in the human breast cancer cell line MCF-7: an hypothesis for the interaction with a site distinct from the estrogen binding site. Molecular and cellular endocrinology, 1994, Volume: 99, Issue:2 Topics: Binding, Competitive; Breast Neoplasms; Cell Division; Cell Fractionation; Centrifugation, Density Gradient; Cytosol; Estradiol; Estrogen Antagonists; Humans; Pyrrolidines; Receptors, Estrogen; Tamoxifen; Thiophenes; Tumor Cells, Cultured	1994
Molecular structures, conformational analysis, and preferential modes of binding of 3-aroyl-2-arylbenzo[b]thiophene estrogen receptor ligands: LY117018 and aryl azide photoaffinity labeling analogs. Journal of medicinal chemistry, 1993, Nov-26, Volume: 36, Issue:24 Topics: Affinity Labels; Azides; Chemical Phenomena; Chemistry, Physical; Computer Simulation; Crystallography, X-Ray; Estrogen Antagonists; Models, Molecular; Molecular Conformation; Molecular Structure; Photochemistry; Pyrrolidines; Receptors, Estrogen; Thiophenes	1993
Activated estrogen receptor mediates growth arrest and differentiation of a neuroblastoma cell line. Proceedings of the National Academy of Sciences of the United States of America, 1993, Apr-15, Volume: 90, Issue:8 Topics: Cell Differentiation; Cell Division; Chloramphenicol O-Acetyltransferase; Estradiol; Estrogen Antagonists; Humans; Kinetics; Neuroblastoma; Pyrrolidines; Receptors, Estrogen; Recombinant Fusion Proteins; Thiophenes; Thymidine; Time Factors; Transfection; Tumor Cells, Cultured	1993
Regulation of progesterone receptor gene expression and growth in the rat uterus: modulation of estrogen actions by progesterone and sex steroid hormone antagonists. Endocrinology, 1993, Volume: 132, Issue:6 Topics: Animals; Dose-Response Relationship, Drug; Estradiol; Estrogen Antagonists; Estrogens; Female; Gene Expression Regulation; Gonadal Steroid Hormones; Mifepristone; Progesterone; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Estrogen; Receptors, Progesterone; Thiophenes; Uterus	1993
Raloxifene analog (LY117018 HCL) ameliorates cyclosporin A-induced osteopenia in oophorectomized rats. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 1996, Volume: 11, Issue:8 Topics: Animals; Bone and Bones; Bone Diseases, Metabolic; Cyclosporine; Drug Evaluation, Preclinical; Drug Synergism; Estrogen Antagonists; Estrogens; Female; Liver; Ovariectomy; Ovary; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Estrogen; Thiophenes; Uterus	1996
The effect of a selective estrogen receptor modulator on the progression of spontaneous autoimmune disease in MRL lpr/lpr mice. Cellular immunology, 1996, Oct-10, Volume: 173, Issue:1 Topics: Animals; Autoimmune Diseases; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Disease Models, Animal; Disease Progression; Estradiol Congeners; Estrogen Antagonists; Ethinyl Estradiol; Female; Kidney; Lupus Erythematosus, Systemic; Lymph Nodes; Mice; Mice, Inbred MRL lpr; Molecular Structure; Pyrrolidines; Receptors, Estrogen; Thiophenes; Thymus Gland	1996
Inhibition of LDL oxidation and myeloperoxidase dependent tyrosyl radical formation by the selective estrogen receptor modulator raloxifene (LY139481 HCL). Atherosclerosis, 1996, Sep-27, Volume: 126, Issue:1 Topics: Animals; Antioxidants; Copper; Dexamethasone; Estradiol; Estrogen Antagonists; Free Radicals; Horseradish Peroxidase; Humans; Lipoproteins, LDL; Macrophages, Peritoneal; Mice; Mice, Inbred BALB C; Oxidation-Reduction; Peroxidase; Phagocytosis; Piperidines; Probucol; Pyrrolidines; Raloxifene Hydrochloride; Receptors, Estrogen; Thiobarbituric Acid Reactive Substances; Thiophenes; Tyrosine	1996
Estrogen and selective estrogen receptor modulator LY117018 enhance release of nitric oxide in rat aorta. The Journal of pharmacology and experimental therapeutics, 1997, Volume: 283, Issue:1 Topics: Acetylcholine; Animals; Aorta, Thoracic; Calcium; Dose-Response Relationship, Drug; Estradiol; Estrogens; Female; In Vitro Techniques; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroprusside; Pyrrolidines; Rats; Rats, Sprague-Dawley; Thiophenes	1997
Effects of LY-117018 HCl on bone remodeling and mineral density in the oophorectomized rat. American journal of obstetrics and gynecology, 1998, Volume: 178, Issue:2 Topics: Acid Phosphatase; Alkaline Phosphatase; Animals; Body Weight; Bone Density; Bone Remodeling; Calcium; Collagen; Collagen Type I; Creatinine; Estrogen Antagonists; Ethinyl Estradiol; Female; Organ Size; Osteocalcin; Ovariectomy; Peptides; Pyrrolidines; Rats; Rats, Wistar; Tartrates; Thiophenes; Uterus	1998
Inhibition of LDL oxidation by a new estradiol receptor modulator compound LY-139478, comparative effect with other steroids. Atherosclerosis, 1998, Volume: 136, Issue:2 Topics: Antioxidants; Copper Sulfate; Dehydroepiandrosterone; Dehydroepiandrosterone Sulfate; Dose-Response Relationship, Drug; Electrophoresis, Agar Gel; Estradiol; Estrogen Antagonists; Gonadal Steroid Hormones; Humans; In Vitro Techniques; Lipoproteins, LDL; Malondialdehyde; Oxidation-Reduction; Pyrrolidines; Superoxides; Testosterone; Thiobarbituric Acid Reactive Substances; Thiophenes	1998
The preventive and interventional effects of raloxifene analog (LY117018 HCL) on osteopenia in ovariectomized rats. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 1998, Volume: 13, Issue:6 Topics: Absorptiometry, Photon; Amino Acids; Animals; Bone Density; Bone Diseases, Metabolic; Bone Resorption; Cholesterol; Estrogen Antagonists; Female; Humans; Injections, Subcutaneous; Lumbar Vertebrae; Osteocalcin; Ovariectomy; Pyrrolidines; Rats; Rats, Wistar; Thiophenes	1998
Selective estrogen receptor modulators: different actions on vascular cell adhesion molecule-1 (VCAM-1) expression in human endothelial cells. The Journal of clinical endocrinology and metabolism, 1999, Volume: 84, Issue:2 Topics: Cells, Cultured; Endothelium, Vascular; Estradiol; Estrogen Antagonists; Gene Expression; Humans; Lipopolysaccharides; Pyrrolidines; Receptors, Estrogen; RNA, Messenger; Saphenous Vein; Tamoxifen; Thiophenes; Vascular Cell Adhesion Molecule-1	1999
The addition of a raloxifene analog (LY117018) allows for reduced PTH(1-34) dosing during reversal of osteopenia in ovariectomized rats. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, 1999, Volume: 14, Issue:5 Topics: Animals; Bone Density; Bone Diseases, Metabolic; Estrogen Antagonists; Female; Humans; Ovariectomy; Pyrrolidines; Rats; Rats, Sprague-Dawley; Teriparatide; Thiophenes	1999
Assessment of maintenance therapy with reduced doses of PTH(1-34) in combination with a raloxifene analogue (LY117018) following anabolic therapy in the ovariectomized rat. Bone, 1999, Volume: 24, Issue:5 Topics: Absorptiometry, Photon; Animals; Bone and Bones; Bone Density; Bone Diseases, Metabolic; Dose-Response Relationship, Drug; Drug Therapy, Combination; Estrogen Antagonists; Female; Humans; Ovariectomy; Pyrrolidines; Rats; Rats, Sprague-Dawley; Teriparatide; Thiophenes; Treatment Outcome	1999
Raloxifene analog LY 117018 effects on central and peripheral beta-endorphin. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 1999, Volume: 13, Issue:4 Topics: Animals; beta-Endorphin; Estradiol; Estrogen Antagonists; Female; Hippocampus; Hypothalamus; Nervous System; Ovariectomy; Pituitary Gland, Anterior; Pituitary Gland, Posterior; Pyrrolidines; Raloxifene Hydrochloride; Rats; Rats, Wistar; Thiophenes	1999
Protective effect of the selective estrogen receptor modulator LY117018 on rat vaginal Candida albicans colonization. Gynecologic and obstetric investigation, 2000, Volume: 49, Issue:1 Topics: Animals; Candida albicans; Estradiol; Estrogen Antagonists; Female; Ovariectomy; Pyrrolidines; Rats; Rats, Sprague-Dawley; Thiophenes; Vagina; Vaginal Smears	2000
Effect of raloxifene-analog (LY 117018-Hcl) on the bone marrow of ovariectomized mice. Journal of cellular biochemistry, 2000, Volume: 76, Issue:3 Topics: Alkaline Phosphatase; Animals; Bone Marrow Cells; Cell Differentiation; Colony-Forming Units Assay; Estrogen Receptor Modulators; Female; Hematopoiesis; Hematopoietic Stem Cells; Mice; Ovariectomy; Pyrrolidines; Selective Estrogen Receptor Modulators; Stromal Cells; Thiophenes; Triglycerides	2000
Selective estrogen receptor modulators suppress mesangial cell collagen synthesis. American journal of physiology. Renal physiology, 2000, Volume: 279, Issue:2 Topics: Angiotensin II; Animals; Cell Line, Transformed; Collagen; Endothelin-1; Estrogen Receptor beta; Estrogens; Glomerular Mesangium; Mice; Mice, Inbred Strains; Mitogen-Activated Protein Kinases; Pyrrolidines; Receptors, Estrogen; Selective Estrogen Receptor Modulators; Tamoxifen; Thiophenes; Transcription Factor AP-1; Transcription, Genetic; Transforming Growth Factor beta; Up-Regulation	2000
17beta-estradiol, but not raloxifene, decreases thrombomodulin in the antithrombotic protein C pathway. Endocrinology, 2000, Volume: 141, Issue:10 Topics: Cells, Cultured; Dose-Response Relationship, Drug; Endothelium, Vascular; Estradiol; Estrogen Antagonists; Humans; Protein C; Pyrrolidines; Raloxifene Hydrochloride; Thiophenes; Thrombomodulin; Thrombosis; Umbilical Veins	2000
Effects of estradiol and raloxifene analog on brain, adrenal and serum allopregnanolone content in fertile and ovariectomized female rats. Neuroendocrinology, 2000, Volume: 72, Issue:3 Topics: Adrenal Glands; Animals; Brain; Drug Combinations; Drug Interactions; Estradiol; Estrogen Antagonists; Female; Fertility; Hippocampus; Hypothalamus; Ovariectomy; Pituitary Gland; Pregnanolone; Pyrrolidines; Raloxifene Hydrochloride; Rats; Rats, Wistar; Thiophenes	2000
Effects of raloxifene, a selective estrogen receptor modulator, on thymus, T cell reactivity, and inflammation in mice. Cellular immunology, 2000, Nov-01, Volume: 205, Issue:2 Topics: Animals; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cell Division; Estradiol; Estrogen Antagonists; Female; Hypersensitivity, Delayed; Mice; Mice, Inbred C57BL; Mice, Inbred MRL lpr; Mice, SCID; Molecular Structure; Pyrrolidines; Raloxifene Hydrochloride; Selective Estrogen Receptor Modulators; Thiophenes; Thymus Gland	2000
Effects of LY117018 and the estrogen analogue, 17alpha-ethinylestradiol, on vascular reactivity, platelet aggregation, and lipid metabolism in the insulin-resistant JCR:LA-cp male rat: role of nitric oxide. Journal of cardiovascular pharmacology, 2001, Volume: 37, Issue:1 Topics: Animals; Aorta; Blood Pressure; Body Weight; Cholesterol Esters; Eating; Enzyme Inhibitors; Estradiol Congeners; Estrogen Antagonists; Ethinyl Estradiol; Insulin Resistance; Lipid Metabolism; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Platelet Aggregation; Pyrrolidines; Rats; Thiophenes; Triglycerides; Vasoconstriction	2001
The in vitro inhibitory action of antiprogestin RU486 on LH and FSH secretion in the absence of progesterone in rats is estrogen-dependent. Pituitary, 2000, Volume: 3, Issue:3 Topics: Animals; Estradiol; Estrogen Antagonists; Estrus; Female; Follicle Stimulating Hormone; Gonadotropin-Releasing Hormone; Hormone Antagonists; In Vitro Techniques; Luteinizing Hormone; Male; Mifepristone; Ovariectomy; Pituitary Gland; Progesterone; Progestins; Pyrrolidines; Rats; Rats, Wistar; Thiophenes	2000
Analysis of cross-resistance of the selective estrogen receptor modulators arzoxifene (LY353381) and LY117018 in tamoxifen-stimulated breast cancer xenografts. Clinical cancer research : an official journal of the American Association for Cancer Research, 2001, Volume: 7, Issue:8 Topics: Animals; Breast Neoplasms; Drug Resistance, Neoplasm; Estradiol; Female; Humans; Mice; Mice, Nude; Piperidines; Pyrrolidines; Selective Estrogen Receptor Modulators; Tamoxifen; Thiophenes; Time Factors; Treatment Outcome; Tumor Cells, Cultured; Xenograft Model Antitumor Assays	2001
Induction of endothelial nitric-oxide synthase phosphorylation by the raloxifene analog LY117018 is differentially mediated by Akt and extracellular signal-regulated protein kinase in vascular endothelial cells. The Journal of biological chemistry, 2001, Dec-14, Volume: 276, Issue:50 Topics: Animals; Cell Line, Transformed; Cells, Cultured; CHO Cells; Cricetinae; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Estradiol; Estrogen Antagonists; Estrogens; Flavonoids; Fulvestrant; Humans; Lung; Mitogen-Activated Protein Kinases; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Phosphorylation; Protein Binding; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pyrrolidines; Raloxifene Hydrochloride; Rats; Receptors, Estradiol; Thiophenes; Time Factors; Umbilical Veins	2001
Effects of selective estrogen receptor modulators (SERMs) on coactivator nuclear receptor (NR) box binding to estrogen receptors. Molecular genetics and metabolism, 2002, Volume: 76, Issue:3 Topics: Amino Acid Sequence; Estradiol; Fluorescence; Fulvestrant; Molecular Sequence Data; Protein Binding; Pyrrolidines; Receptors, Cytoplasmic and Nuclear; Selective Estrogen Receptor Modulators; Thiophenes	2002
Effects of progesterone (P) and antiprogestin RU486 on LH and FSH release by incubated pituitaries from rats treated with the SERM LY11701 8-HCl and/or recombinant human FSH. Journal of endocrinological investigation, 2002, Volume: 25, Issue:8 Topics: Animals; Control Groups; Estradiol; Female; Follicle Stimulating Hormone; Gonadotropin-Releasing Hormone; Hormone Antagonists; Humans; In Vitro Techniques; Luteinizing Hormone; Mifepristone; Pituitary Gland; Progesterone; Pyrrolidines; Rats; Rats, Wistar; Recombinant Proteins; Selective Estrogen Receptor Modulators; Thiophenes	2002
Raloxifene- and estradiol-mediated effects on uterus, bone and B lymphocytes in mice. The Journal of endocrinology, 2002, Volume: 175, Issue:2 Topics: Animals; B-Lymphocytes; Bone and Bones; Estradiol; Female; Flow Cytometry; Immunoenzyme Techniques; Insulin-Like Growth Factor I; Lymphopoiesis; Mice; Mice, Inbred C57BL; Pyrrolidines; Selective Estrogen Receptor Modulators; Spleen; Thiophenes; Tomography, X-Ray Computed; Uterus	2002
Effect of treatment with the selective oestrogen receptor modulator LY117018-HCl on pituitary sensitivity to GnRH and subsequent ovulation. Reproduction (Cambridge, England), 2003, Volume: 125, Issue:4 Topics: Animals; Depression, Chemical; Diestrus; Estradiol; Feedback, Physiological; Female; Gonadotropin-Releasing Hormone; Luteinizing Hormone; Ovariectomy; Ovulation; Pituitary Gland; Pyrrolidines; Rats; Rats, Sprague-Dawley; Selective Estrogen Receptor Modulators; Thiophenes	2003
Raloxifene analog LY117018 enhances the regeneration of sciatic nerve in ovariectomized female mice. Brain research, 2003, Aug-01, Volume: 980, Issue:1 Topics: Animals; Estrogen Antagonists; Female; Histological Techniques; Mice; Mice, Inbred ICR; Nerve Regeneration; Ovariectomy; Pyrrolidines; Raloxifene Hydrochloride; Sciatic Nerve; Selective Estrogen Receptor Modulators; Thiophenes; Time Factors	2003
Histone deacetylase inhibition and estrogen receptor alpha levels modulate the transcriptional activity of partial antiestrogens. Journal of molecular endocrinology, 2004, Volume: 32, Issue:2 Topics: Breast Neoplasms; Enzyme Inhibitors; Estradiol; Estrogen Receptor alpha; Estrogen Receptor beta; Estrogen Receptor Modulators; Female; Fulvestrant; Genes, Reporter; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Pyrrolidines; Raloxifene Hydrochloride; Response Elements; Tamoxifen; Thiophenes; Transcription, Genetic; Tumor Cells, Cultured	2004
Effects of the selective estrogen receptor modulator LY117018 on growth hormone secretion: In vitro studies. Metabolism: clinical and experimental, 2004, Volume: 53, Issue:5 Topics: Adenoma; Adult; Aged; Animals; Cell Division; Cells, Cultured; Dose-Response Relationship, Drug; Estradiol; Female; Growth Hormone; Growth Hormone-Releasing Hormone; Humans; Male; Middle Aged; Pituitary Gland; Pyrrolidines; Raloxifene Hydrochloride; Rats; Rats, Sprague-Dawley; Secretory Rate; Selective Estrogen Receptor Modulators; Tamoxifen; Thiophenes	2004
Modulation of survival in osteoblasts from postmenopausal women. Bone, 2004, Volume: 35, Issue:1 Topics: Aged; Apoptosis; Cell Survival; Cells, Cultured; Estradiol; Estrogens; fas Receptor; Female; Humans; Middle Aged; Osteoblasts; Osteoporosis, Postmenopausal; Postmenopause; Pyrrolidines; Receptors, Tumor Necrosis Factor; Selective Estrogen Receptor Modulators; Thiophenes; Tumor Necrosis Factor-alpha	2004
Tamoxifen and the Rafoxifene analog LY117018: their effects on arachidonic acid release from cells in culture and on prostaglandin I2 production by rat liver cells. BMC cancer, 2004, Aug-13, Volume: 4 Topics: Animals; Antineoplastic Agents, Hormonal; Arachidonic Acid; Breast Neoplasms; Colonic Neoplasms; Cyclooxygenase 2; Epoprostenol; Estrogen Antagonists; Humans; Isoenzymes; Liver; Membrane Proteins; Prostaglandin-Endoperoxide Synthases; Pyrrolidines; Rats; Receptors, Estrogen; Tamoxifen; Thiophenes; Tumor Cells, Cultured	2004
Ligand-independent and agonist-mediated degradation of estrogen receptor-alpha in breast carcinoma cells: evidence for distinct degradative pathways. Molecular and cellular endocrinology, 2004, Nov-30, Volume: 227, Issue:1-2 Topics: Breast Neoplasms; Cycloheximide; Enzyme Inhibitors; Estrogen Antagonists; Estrogen Receptor alpha; Female; Fluorescent Antibody Technique; Gene Expression Regulation, Neoplastic; HSP90 Heat-Shock Proteins; Humans; Immunoenzyme Techniques; Lactones; Leupeptins; Ligands; Macrolides; Molecular Chaperones; Proteasome Inhibitors; Protein Synthesis Inhibitors; Protein-Tyrosine Kinases; Pyrrolidines; Signal Transduction; Tamoxifen; Thiophenes; Tumor Cells, Cultured	2004
Anti-growth factor activities of benzothiophenes in human breast cancer cells. The Journal of steroid biochemistry and molecular biology, 2005, Volume: 94, Issue:5 Topics: Breast Neoplasms; Cell Proliferation; Estrogen Antagonists; Humans; Insulin-Like Growth Factor I; Phosphorylation; Protein Serine-Threonine Kinases; Protein Tyrosine Phosphatase, Non-Receptor Type 13; Protein Tyrosine Phosphatases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Pyrrolidines; Raloxifene Hydrochloride; Selective Estrogen Receptor Modulators; Thiophenes; Transcription Factor AP-1; Transcription, Genetic	2005
Human splicing factor SPF45 (RBM17) confers broad multidrug resistance to anticancer drugs when overexpressed--a phenotype partially reversed by selective estrogen receptor modulators. Cancer research, 2005, Aug-01, Volume: 65, Issue:15 Topics: Antineoplastic Agents; Cell Line, Tumor; Doxorubicin; Drug Resistance, Multiple; Drug Resistance, Neoplasm; Estrogen Receptor beta; Etoposide; Female; Humans; Mitoxantrone; Ovarian Neoplasms; Pyrrolidines; RNA Splicing; RNA Splicing Factors; RNA-Binding Proteins; RNA, Catalytic; Selective Estrogen Receptor Modulators; Tamoxifen; Thiophenes; Transfection	2005
Activity of estradiol and selective estrogen receptor modulators in the mouse N20.1 oligodendrocyte/astrocytes cell line. Neuro endocrinology letters, 2005, Volume: 26, Issue:5 Topics: Animals; Astrocytes; Blotting, Western; Cell Line; Estradiol; Estrogen Antagonists; Estrogen Receptor alpha; Estrogen Receptor beta; Gene Expression Regulation; Ligands; Luciferases; Mice; Neuroglia; Oligodendroglia; Plasmids; Pyrrolidines; Raloxifene Hydrochloride; Selective Estrogen Receptor Modulators; Tamoxifen; Thiophenes; Transfection	2005
AIB1 gene amplification and the instability of polyQ encoding sequence in breast cancer cell lines. BMC cancer, 2006, May-02, Volume: 6 Topics: Acetyltransferases; Alleles; Breast Neoplasms; Cell Line, Tumor; Cloning, Molecular; Drug Resistance, Neoplasm; Estradiol; Fulvestrant; Histone Acetyltransferases; Humans; Nuclear Receptor Coactivator 3; Oncogene Proteins; Peptides; Polymerase Chain Reaction; Pyrrolidines; Raloxifene Hydrochloride; Reverse Transcriptase Polymerase Chain Reaction; Selective Estrogen Receptor Modulators; Sequence Analysis, DNA; Tamoxifen; Thiophenes; Trans-Activators	2006
Selective estrogen receptor modulator inhibits osteocyte apoptosis during abrupt estrogen withdrawal: implications for bone quality maintenance. Calcified tissue international, 2007, Volume: 81, Issue:2 Topics: Animals; Apoptosis; Bone and Bones; Bone Density; Cell Survival; Dose-Response Relationship, Drug; Estradiol; Estrogen Receptor alpha; Estrogens; Female; Humans; Osteocytes; Osteoporosis, Postmenopausal; Pyrrolidines; Rats; Rats, Sprague-Dawley; Selective Estrogen Receptor Modulators; Thiophenes; Treatment Outcome	2007
Role of raloxifene as a potent inhibitor of experimental postmenopausal polyarthritis and osteoporosis. Arthritis and rheumatism, 2007, Volume: 56, Issue:10 Topics: Animals; Arthritis; Arthritis, Experimental; Bone Density; Cytokines; Female; Humans; Mice; Osteoporosis, Postmenopausal; Postmenopause; Pyrrolidines; Raloxifene Hydrochloride; RANK Ligand; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Selective Estrogen Receptor Modulators; Thiophenes; Treatment Outcome; Tumor Necrosis Factor-alpha	2007
Morphologic effects of epithelial ion channels on the mouse uterus: differences between raloxifene analog (LY117018) and estradiol treatments. American journal of obstetrics and gynecology, 2008, Volume: 199, Issue:4 Topics: Animals; Cystic Fibrosis Transmembrane Conductance Regulator; Epithelial Sodium Channels; Estradiol; Female; Mice; Mice, Inbred ICR; Organ Size; Pyrrolidines; RNA, Messenger; Selective Estrogen Receptor Modulators; Thiophenes; Uterus	2008
Raloxifene analogue LY117018 suppresses oxidative stress-induced endothelial cell apoptosis through activation of ERK1/2 signaling pathway. European journal of pharmacology, 2008, Jul-28, Volume: 589, Issue:1-3 Topics: Animals; Apoptosis; Cattle; Cells, Cultured; Dose-Response Relationship, Drug; Endothelial Cells; Enzyme Activation; Estradiol; Estrogen Antagonists; Flavonoids; Fulvestrant; Hydrogen Peroxide; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Oxidants; Oxidative Stress; Phosphorylation; Protein Kinase Inhibitors; Pyrrolidines; Raloxifene Hydrochloride; Receptors, Estrogen; Selective Estrogen Receptor Modulators; Thiophenes	2008
A selective estrogen receptor modulator inhibits TNF-alpha-induced apoptosis by activating ERK1/2 signaling pathway in vascular endothelial cells. Vascular pharmacology, 2009, Volume: 51, Issue:1 Topics: Animals; Apoptosis; Cattle; Cell Survival; Cells, Cultured; Endothelial Cells; Enzyme Activation; MAP Kinase Signaling System; Mitogen-Activated Protein Kinase 1; Mitogen-Activated Protein Kinase 3; Pyrrolidines; Selective Estrogen Receptor Modulators; Thiophenes; Tumor Necrosis Factor-alpha	2009
In vivo activation of gene transcription via oestrogen response elements by a raloxifene analogue. The Journal of endocrinology, 2009, Volume: 203, Issue:3 Topics: Animals; Bone Density; Estradiol; Estrogen Antagonists; Estrogens; Female; Femur; Luciferases; Mice; Mice, Inbred CBA; Mice, Transgenic; Organ Size; Pyrrolidines; Raloxifene Hydrochloride; Receptors, Estrogen; Response Elements; Thiophenes; Thymus Gland; Transcription, Genetic; Uterus	2009
Effect of selective estrogen receptor modulator/raloxifene analogue on proliferation and collagen metabolism of tendon fibroblast. Connective tissue research, 2010, Volume: 51, Issue:3 Topics: Achilles Tendon; Animals; Bromodeoxyuridine; Cell Proliferation; Cell Survival; Cells, Cultured; Collagen Type I; Collagen Type III; Elastin; Estradiol; Estrogen Antagonists; Extracellular Matrix; Female; Fibroblasts; Fulvestrant; Matrix Metalloproteinase 13; Pyrrolidines; Raloxifene Hydrochloride; Rats; Selective Estrogen Receptor Modulators; Tetrazolium Salts; Thiophenes	2010
Mechanisms involved in the inhibition of osteoclast generation by the benzothiophene SERM LY117018. Wiener klinische Wochenschrift, 2010, Volume: 122, Issue:21-22 Topics: Animals; Animals, Newborn; Cell Differentiation; Cell Proliferation; Cell Survival; Cells, Cultured; Cytokines; Dose-Response Relationship, Drug; Mice; Osteoclasts; Pyrrolidines; Selective Estrogen Receptor Modulators; Thiophenes	2010