Page last updated: 2024-09-03

luzindole and prazosin

luzindole has been researched along with prazosin in 16 studies

Compound Research Comparison

Studies
(luzindole)
Trials
(luzindole)
Recent Studies (post-2010)
(luzindole)
Studies
(prazosin)
Trials
(prazosin)
Recent Studies (post-2010) (prazosin)
26511197,914713682

Protein Interaction Comparison

ProteinTaxonomyluzindole (IC50)prazosin (IC50)
Solute carrier family 22 member 1 Homo sapiens (human)5.87
Interstitial collagenaseHomo sapiens (human)4.036
Alpha-2A adrenergic receptorHomo sapiens (human)2.638
Matrix metalloproteinase-9Homo sapiens (human)6.963
Alpha-1B adrenergic receptorRattus norvegicus (Norway rat)0.0008
Ribosyldihydronicotinamide dehydrogenase [quinone]Homo sapiens (human)0.0078
Alpha-2B adrenergic receptorHomo sapiens (human)0.29
Alpha-2C adrenergic receptorHomo sapiens (human)0.647
Alpha-1D adrenergic receptorRattus norvegicus (Norway rat)0.0008
Alpha-1D adrenergic receptorHomo sapiens (human)0.0007
Bromodomain-containing protein 2Homo sapiens (human)0.0009
Alpha-1A adrenergic receptorHomo sapiens (human)0.0006
Alpha-1B adrenergic receptorHomo sapiens (human)0.0006
5-hydroxytryptamine receptor 2BHomo sapiens (human)4.118
Alpha-1A adrenergic receptorRattus norvegicus (Norway rat)0.0008
5-hydroxytryptamine receptor 7Cavia porcellus (domestic guinea pig)9.9
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)1.5849
Multidrug and toxin extrusion protein 1Homo sapiens (human)1.6

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's5 (31.25)29.6817
2010's11 (68.75)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Cao, XD; Wu, GC; Xu, SF; Yu, CX; Zhu, CB1
Kulkarni, SK; Naidu, PS; Raghavendra, V1
Flemström, G; Jedstedt, G; Sjöblom, M1
Cao, YX; Ding, CN; Fei, MY; Shen, ZY; Yu, P; Zhou, L; Zhu, DN1
Castrucci, AM; Souza, AV; Visconti, MA1
Cardaci, E; Colantuoni, A; Lapi, D; Paterni, M; Vagnani, S1
Dehpour, AR; Hojati, A; Moezi, L; Shafaroodi, H1
Ahmed, F; Mubashshir, M; Ovais, M1
Ahmed, F; Mubashshir, MD; Ovais, M; Sumoona, S1
Adamczyk-Sowa, M; Bartosz, G; Pierzchala, K; Sadowska-Bartosz, I; Sowa, P; Zwirska-Korczala, K1
Cao, J; Chen, Y; Dong, Y; Li, J; Wang, Z1
Adamczyk-Sowa, M; Pierzchala, K; Sowa, P; Zwirska-Korczala, K1
Adam, T; Lamont, K; Lecour, S; Nduhirabandi, F; Opie, LH; Thomas, DP1
Cao, J; Chen, F; Chen, Y; Dong, Y; Reheman, A; Wang, Z; Zhang, Y1
Li, W; Lv, J; Mao, C; Tao, J; Xu, Z; Zhang, P1
Aydin, L; Baltaci, AK; Mogulkoc, R1

Other Studies

16 other study(ies) available for luzindole and prazosin

ArticleYear
Selective MT(2) melatonin receptor antagonist blocks melatonin-induced antinociception in rats.
    Neuroscience letters, 2000, Mar-24, Volume: 282, Issue:3

    Topics: Analgesics; Animals; Injections, Intraventricular; Male; Melatonin; Pain Measurement; Pain Threshold; Prazosin; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Tryptamines

2000
Reversal of reserpine-induced vacuous chewing movements in rats by melatonin: involvement of peripheral benzodiazepine receptors.
    Brain research, 2001, Jun-15, Volume: 904, Issue:1

    Topics: Adrenergic alpha-Antagonists; Adrenergic Uptake Inhibitors; Animals; Antineoplastic Agents; Dose-Response Relationship, Drug; Drug Interactions; Dyskinesia, Drug-Induced; Flumazenil; GABA Modulators; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Isoquinolines; Male; Mastication; Melatonin; Neostriatum; Prazosin; Rats; Rats, Wistar; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, GABA-A; Receptors, Melatonin; Reserpine; Tryptamines

2001
Peripheral melatonin mediates neural stimulation of duodenal mucosal bicarbonate secretion.
    The Journal of clinical investigation, 2001, Volume: 108, Issue:4

    Topics: Adrenocorticotropic Hormone; Animals; Bicarbonates; Blood Pressure; Circadian Rhythm; Corticotropin-Releasing Hormone; Duodenum; Enterochromaffin Cells; gamma-MSH; Hypophysectomy; Injections, Intra-Arterial; Injections, Intraventricular; Intestinal Mucosa; Melatonin; Neurosecretion; Phenylephrine; Pineal Gland; Prazosin; Protein Isoforms; Rats; Rats, Inbred Lew; Rats, Sprague-Dawley; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Tetrahydronaphthalenes; Thiopental; Tryptamines; Vagotomy

2001
Effects of microinjection of melatonin and its receptor antagonists into anterior hypothalamic area on blood pressure and heart rate in rats.
    Acta pharmacologica Sinica, 2001, Volume: 22, Issue:11

    Topics: Animals; Anterior Hypothalamic Nucleus; Blood Pressure; Heart Rate; Male; Melatonin; Microinjections; Prazosin; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Tryptamines

2001
Melatonin biological activity and binding sites in human melanoma cells.
    Journal of pineal research, 2003, Volume: 34, Issue:4

    Topics: Binding Sites; Binding, Competitive; Cell Division; Humans; Iodine Radioisotopes; Melanoma; Melatonin; Monophenol Monooxygenase; Prazosin; Serotonin; Tryptamines; Tumor Cells, Cultured

2003
Rat pial microvascular responses to melatonin during bilateral common carotid artery occlusion and reperfusion.
    Journal of pineal research, 2011, Volume: 51, Issue:1

    Topics: Analysis of Variance; Animals; Capillary Permeability; Carotid Artery, Common; Carotid Stenosis; Cerebral Veins; Male; Melatonin; Microvessels; Pia Mater; Prazosin; Rats; Rats, Wistar; Reactive Oxygen Species; Receptors, Melatonin; Reperfusion; Statistics, Nonparametric; Tryptamines

2011
The interaction of melatonin and agmatine on pentylenetetrazole-induced seizure threshold in mice.
    Epilepsy & behavior : E&B, 2011, Volume: 22, Issue:2

    Topics: Agmatine; Analysis of Variance; Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Male; Melatonin; Mice; Pentylenetetrazole; Prazosin; Receptors, Melatonin; Seizures; Time Factors; Tryptamines

2011
Study of the effects of the casein derived bitter tastant on the melanophores in milieu with the melatonin receptors.
    Journal of receptor and signal transduction research, 2011, Volume: 31, Issue:5

    Topics: Animals; Carps; Caseins; Cell Size; Denervation; Indoles; Melanophores; Neurotransmitter Agents; Piperazines; Prazosin; Receptor, Melatonin, MT1; Receptor, Melatonin, MT2; Receptors, Adrenergic; Tryptamines; Yohimbine

2011
Analyzing the responses of saccharin in context with melatonin receptors on the melanophores of the fish Labeo rohita (Ham.).
    Journal of receptor and signal transduction research, 2012, Volume: 32, Issue:2

    Topics: Adrenergic alpha-1 Receptor Antagonists; Animals; Denervation; Fishes; Indoles; Melanophores; Melatonin; Prazosin; Receptors, Melatonin; Saccharin; Signal Transduction; Sweetening Agents; Tryptamines

2012
Role of melatonin receptor MT(2) and quinone reductase II in the regulation of the redox status of 3T3-L1 preadipocytes in vitro.
    Cell biology international, 2013, Volume: 37, Issue:8

    Topics: 3T3-L1 Cells; Adipocytes; Animals; Catalase; Glutathione Peroxidase; Glutathione Reductase; Malondialdehyde; Melatonin; Mice; Oxidation-Reduction; Oxidative Stress; Prazosin; Quinone Reductases; Receptor, Melatonin, MT2; Superoxide Dismutase; Tryptamines

2013
Melatonin receptor subtypes Mel1a and Mel1c but not Mel1b are associated with monochromatic light-induced B-lymphocyte proliferation in broilers.
    Domestic animal endocrinology, 2013, Volume: 45, Issue:4

    Topics: Animals; B-Lymphocytes; Bucladesine; Bursa of Fabricius; Cell Proliferation; Chickens; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dibucaine; Light; Melatonin; Prazosin; Receptors, Melatonin; RNA, Messenger; Tryptamines

2013
Labeled [³H]--thymidine incorporation in the DNA of 3T3-L1 preadipocytes due to MT₂- and not MT₃- melatonin receptor.
    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2014, Volume: 65, Issue:1

    Topics: 3T3-L1 Cells; Adipocytes; Animals; Cell Proliferation; DNA; Melatonin; Mice; Prazosin; Receptor, Melatonin, MT2; Receptors, Melatonin; Thymidine; Tryptamines

2014
Role of melatonin, melatonin receptors and STAT3 in the cardioprotective effect of chronic and moderate consumption of red wine.
    Biochemical and biophysical research communications, 2015, Oct-02, Volume: 465, Issue:4

    Topics: Animals; Cardiotonic Agents; Male; Melatonin; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocardial Infarction; Prazosin; Rats; Rats, Wistar; Receptor, Melatonin, MT1; Receptor, Melatonin, MT2; Receptors, Melatonin; Receptors, Tumor Necrosis Factor, Type II; STAT3 Transcription Factor; Tryptamines; Tyrphostins; Wine

2015
Effect of melatonin on monochromatic light-induced T-lymphocyte proliferation in the thymus of chickens.
    Journal of photochemistry and photobiology. B, Biology, 2016, Volume: 161

    Topics: Animals; Cell Proliferation; Cells, Cultured; Chickens; Concanavalin A; Gene Expression; Immunohistochemistry; Light; Male; Melatonin; Prazosin; Proliferating Cell Nuclear Antigen; Receptors, Melatonin; RNA, Messenger; T-Lymphocytes; Tetrahydronaphthalenes; Thymus Gland; Tryptamines

2016
Exogenous melatonin reduced blood pressure in late-term ovine fetus via MT1/MT2 receptor pathways.
    Reproductive biology, 2016, Volume: 16, Issue:3

    Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenocorticotropic Hormone; Aldosterone; Angiotensin I; Angiotensin II; Animals; Atrial Natriuretic Factor; Blood Pressure; Corticotropin-Releasing Hormone; Endothelins; Fetus; Heart Rate; Hydrocortisone; Melatonin; Prazosin; Receptor, Melatonin, MT1; Receptor, Melatonin, MT2; Sheep; Sheep, Domestic; Signal Transduction; Tryptamines

2016
Role of Melatonin Receptors in Hyperthermia-Induced Acute Seizure Model of Rats.
    Journal of molecular neuroscience : MN, 2019, Volume: 69, Issue:4

    Topics: Animals; Anticonvulsants; Brain; Central Nervous System Depressants; Fever; Male; Melatonin; Prazosin; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Melatonin; Seizures, Febrile; Tryptamines

2019