luzindole has been researched along with melatonin in 229 studies
| Studies (luzindole) | Trials (luzindole) | Recent Studies (post-2010) (luzindole) | Studies (melatonin) | Trials (melatonin) | Recent Studies (post-2010) (melatonin) |
|---|---|---|---|---|---|
| 265 | 1 | 119 | 23,268 | 1,451 | 9,627 |
| Protein | Taxonomy | luzindole (IC50) | melatonin (IC50) |
|---|---|---|---|
| Myeloperoxidase | Homo sapiens (human) | 3 | |
| Ribosyldihydronicotinamide dehydrogenase [quinone] | Homo sapiens (human) | 3.3323 | |
| Metabotropic glutamate receptor 1 | Rattus norvegicus (Norway rat) | 0.0004 | |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | 0.0005 | |
| Melatonin receptor type 1A | Homo sapiens (human) | 0.0025 | |
| Melatonin receptor type 1B | Homo sapiens (human) | 0.0035 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (0.44) | 18.7374 |
| 1990's | 24 (10.48) | 18.2507 |
| 2000's | 93 (40.61) | 29.6817 |
| 2010's | 105 (45.85) | 24.3611 |
| 2020's | 6 (2.62) | 2.80 |
| Authors | Studies |
|---|---|
| Dubocovich, ML; Iacob, S; Masana, MI; Sauri, DM | 1 |
| Davies, DJ; Davies, J; Garratt, PJ; Sugden, D; Teh, MT; Tocher, DA; Vonhoff, S | 1 |
| Beresford, I; Browning, C; Fraser, N; Giles, H | 1 |
| Calogeropoulou, T; Faust, R; Garratt, PJ; Jones, R; Panoussopoulou, M; Sugden, D; Teh, MT; Tsotinis, A; Yeh, LK | 1 |
| Bedini, A; Fraschini, F; Lucini, V; Mor, M; Pannacci, M; Plazzi, PV; Rivara, S; Silva, C; Spadoni, G; Tarzia, G; Vacondio, F; Zuliani, V | 1 |
| Amossé, C; Audinot, V; Bonnaud, A; Boutin, JA; Delagrange, P; Dromaint, S; Galizzi, JP; Guillaumet, G; Lahaye-Brasseur, C; Le Gall, A; Lefoulon, F; Lesieur, D; Mailliet, F; Malpaux, B; Nagel, N; Renard, P; Rodriguez, M | 1 |
| Davidson, K; Eleutheriades, A; Panoussopoulou, M; Sugden, D; Tsotinis, A | 1 |
| Afroudakis, PA; Davidson, K; Prashar, A; Sugden, D; Tsotinis, A | 1 |
| Cecon, E; Jockers, R; Rivara, S; Witt-Enderby, PA; Zlotos, DP | 1 |
| Alonso-Gil, S; Conde, S; López, MG; López-Iglesias, B; Morales-García, JA; Pérez, C; Pérez-Castillo, A; Rodríguez-Franco, MI; Romero, A; Villarroya, M | 1 |
| Alonso-Gil, S; Caignard, DH; de la Fuente Revenga, M; Fernández-Sáez, N; Herrera-Arozamena, C; Morales-García, JA; Pérez-Castillo, A; Rivara, S; Rodríguez-Franco, MI | 1 |
| Bocianowska, A; Garratt, PJ; Kompogennitaki, R; Papanastasiou, I; Sugden, D; Tsotinis, A | 1 |
| Sugden, D | 1 |
| Dubocovich, ML | 2 |
| Dubocovich, ML; Duncan, MJ; Fang, JM | 1 |
| Dubocovich, ML; Fang, JM | 1 |
| Areso, PM; Dubocovich, ML; Mogilnicka, E | 1 |
| Gan, J; Iuvone, PM | 1 |
| Barrios, VE; Duckles, SP; Krause, DN | 1 |
| Chong, NW; Sugden, D | 1 |
| Beresford, IJ; Hagan, RM; Starkey, SJ; Walker, MP | 1 |
| Dubocovich, ML; Witt-Enderby, PA | 1 |
| Barrett, P; Canning, SJ; Conway, S; Delagrange, P; Drew, JE; Guardiola-Lemaitre, B; Jockers, R; Morgan, PJ; Strosberg, AD | 1 |
| Duckles, SP; Geary, GG; Krause, DN | 1 |
| Argyriou, A; Philippu, A; Prast, H | 1 |
| Al-Ghoul, WM; Benloucif, S; Dubocovich, ML; Masana, MI; Yun, K | 1 |
| Bush, RA; Iuvone, PM; Sieving, PA; Sugawara, T | 1 |
| Sugden, D; Teh, MT | 1 |
| Bucher, B; Gauer, F; Masson-Pévet, M; Pévet, P | 1 |
| Flanders, S; Lew, MJ | 1 |
| Calvo, JR; García-Pergañeda, A; Guerrero, JM; Paz Romero, M; Pozo, D; Rafii-El-Idrissi, M | 1 |
| Angeloni, D; Fraschini, F; Lucini, V; Nonno, R; Pannacci, M; Stankov, BM | 1 |
| Atkinson, J; Chillon, JM; Delagrange, P; Lartaud-Idjouadiene, I; Régrigny, O; Scalbert, E | 1 |
| Benelli, A; Bertolini, A; Busà, L; Drago, F | 1 |
| Cao, XD; Wu, GC; Xu, SF; Yu, CX; Zhu, CB | 1 |
| Kulkarni, SK; Raghavendra, V | 1 |
| Peschke, D; Peschke, E; Richter, K | 1 |
| Beckmann, A; Fauteck, JD; Musshoff, U; Peschke, D; Peschke, E; Schmidt, F | 1 |
| Ishizuka, B; Kanishi, Y; Kobayashi, Y; Noda, S; Saito, K | 1 |
| Beraldo, FH; Garcia, CR; Gazarini, ML; Hotta, CT; Lopes, C; Markus, RP; Pozzan, T; Varotti, FP | 1 |
| Busa', L; Drago, F | 1 |
| Al-Ghoul, WM; Dubocovich, ML; Gillette, MU; Hunt, AE | 1 |
| Isobe, Y; Nishino, H; Torii, T | 1 |
| Cosma, GN; Frank, AA; Gardner, HS; Scott, AE; Wells, RL | 1 |
| El-Sherif, Y; Hogan, MV; Wieraszko, A | 1 |
| Hoyle, CH; Martin, L; Pelaez, T; Peral, A; Pintor, J | 1 |
| Bilbo, SD; Bilu, D; Drazen, DL; Nelson, RJ | 1 |
| Barrett, P; Conway, S; Delagrange, P; Drew, JE; Morgan, PJ; Mowat, ES | 1 |
| Alonso-Bedate, M; Alonso-Gómez, AL; De Pedro, N; Delgado, MJ; Pinillos, ML | 1 |
| Kulkarni, SK; Naidu, PS; Raghavendra, V | 1 |
| Carta, G; Nava, F | 1 |
| Flemström, G; Jedstedt, G; Sjöblom, M | 1 |
| Drazen, DL; Nelson, RJ | 1 |
| Atkinson, J; Chillon, JM; Delagrange, P; Régrigny, O; Scalbert, E | 1 |
| Angelini, NL; Belsham, DD; Brown, GM; Fujieda, H; Roy, D | 1 |
| Bucelli, R; Lis, A; Rosenblatt, T; Roth, JA | 1 |
| Dubocovich, ML; Farsky, SH; Lopes, C; Lotufo, CM; Markus, RP | 1 |
| Cao, YX; Ding, CN; Fei, MY; Shen, ZY; Yu, P; Zhou, L; Zhu, DN | 1 |
| Bac, P; Evrard, P; Gressens, P; Husson, I; Mesplès, B; Vamecq, J | 1 |
| Berger, E; Fauteck, JD; Musshoff, U; Riewenherm, D; Speckmann, EJ | 1 |
| Markowska, M; Mrozkowiak, A; Skwarlo-Sonta, K | 1 |
| Brzozowska, I; Brzozowski, T; Drozdowicz, D; Hahn, EG; Konturek, PC; Konturek, SJ; Kwiecien, S; Pajdo, R; Pawlik, M; Ptak, A | 1 |
| Kravtsov, GM; Pang, SF; Poon, AM | 1 |
| Chankiewitz, E; Csernus, VJ; Mühlbauer, E; Musshoff, U; Peschke, D; Peschke, E | 1 |
| Drago, F; Macauda, S; Salehi, S | 1 |
| Bonior, J; Jaworek, J; Konturek, SJ; Leja-Szpak, A; Nawrot, K; Pawlik, WW; Stachura, J; Tomaszewska, R | 1 |
| Korf, HW; Mutoh, T; Okamura, H; Shibata, S | 1 |
| Dubocovich, ML; Gerdin, MJ; Masana, MI; Miller, RJ; Ren, D | 1 |
| Castrucci, AM; Souza, AV; Visconti, MA | 1 |
| Flemström, G; Sjöblom, M | 1 |
| Cao, XD; Huang, YS; Jiang, JW; Wu, GC | 1 |
| Hamada, N; Ishizuka, B; Itoh, MT; Kanishi, Y; Kiguchi, K; Kobayashi, Y; Kondo, H; Okuma, Y; Sato, S | 1 |
| Musshoff, U; Speckmann, EJ | 1 |
| Chen, Y; Fung, ML; Ip, SF; Liong, EC; Tipoe, GL; Tjong, YW | 1 |
| Alonso-Bedate, M; Alonso-Gómez, AL; Delgado, MJ; Guijarro, A; Isorna, E | 1 |
| Jaworek, J; Konturek, SJ; Leja-Szpak, A; Nawrot, K; Pawlik, WW; Thor, P | 1 |
| Bujalance, I; Feijóo, M; Montilla, P; Muñoz, MC; Muñoz-Castañeda, JR; Túnez, I | 1 |
| Anhê, GF; Caperuto, LC; Carvalho, CR; Cipolla-Neto, J; Hirata, AE; Pereira-Da-Silva, M; Souza, LC; Velloso, LA | 1 |
| Boccalon, S; Ortolani, F; Perissin, L; Petrelli, L; Porro, CA; Scaggiante, B | 1 |
| Markowska, M; Mrozkowiak, A; Pawlak, J; Skwarło-Sońta, K | 1 |
| Calandra, RS; Frungieri, MB; Gonzalez-Calvar, SI; Mayerhofer, A; Pignataro, OP; Zitta, K | 1 |
| Calvo, JR; Carrillo-Vico, A; Fernández-Santos, JM; Guerrero, JM; Karasek, M; Lardone, PJ; Martín-Lacave, I | 1 |
| Alonso-Vale, MI; Andreotti, S; Anhê, GF; das Neves Borges-Silva, C; Lima, FB; Neto, JC; Peres, SB | 1 |
| Cevík, H; Ercan, F; Erkanli, G; Işman, CA; Yeğen, BC | 1 |
| Chen, Y; Fung, ML; Ip, SF; Tipoe, GL; Tjong, YW | 1 |
| Bryla, J; Derlacz, RA; Jagielski, AK; Napierala, M; Poplawski, P | 1 |
| Hamassaki-Britto, DE; Markus, RP; Sampaio, LF | 1 |
| Audinot, V; Boutin, JA; Delagrange, P; Ferry, G | 1 |
| Carrillo-Vico, A; De Felipe, B; Guerrero, JM; Karasek, M; Lardone, PJ; Naranjo, MC; Vallejo, A | 1 |
| Dubocovich, ML; Masana, MI; Sumaya, IC | 1 |
| Huang, H; Lee, SC; Yang, XL | 1 |
| Chaudhury, D; Colwell, CS; Suthana, NA; Wang, LM; Weaver, DR | 1 |
| Davids, A; Genade, S; Lochner, A; Moolman, JA; Ytrehus, K | 1 |
| Arezzi, A; Drago, F; Micale, V; Rampello, L | 1 |
| Bianchi, R; Bonomini, F; Reiter, RJ; Rezzani, R; Rodella, LF; Tengattini, S | 1 |
| Hoyle, CH; Peral, A; Pintor, J | 1 |
| Acuna-Castroviejo, D; Escames, G; Maldonado, MD; Sánchez-Hidalgo, M; Siu, AW | 1 |
| Brattstroem, A; Butterweck, V; Grundmann, O; Koetter, U | 1 |
| Chen, Q; Cui, SG; Dai, X; Li, SR; Wang, R | 1 |
| Accorsi, A; Albertini, MC; Bucchini, A; Cerella, C; D'Alessio, M; De Nicola, M; Diamantini, G; Ghibelli, L; Paternoster, L; Radogna, F; Spadoni, G; Tarzia, G | 1 |
| Li, F; Liu, RY; Qian, ZX; Zhou, L | 1 |
| Davidson, K; Eleutheriades, A; Sugden, D; Tsotinis, A | 1 |
| Haraguchi, S; Inoue, K; Miyabara, H; Ogura, Y; Suzuki, S; Tsutsui, K | 1 |
| Bennett, JM; Bondi, CD; Brydon, L; Ignatius, PF; Jockers, R; McKeon, RM; Melan, MA; Witt-Enderby, PA | 1 |
| Cerella, C; Cristofanon, S; D'Alessio, M; De Nicola, M; Dicato, M; Diederich, M; Ghibelli, L; Paternoster, L; Radogna, F | 1 |
| Mühlbauer, E; Peschke, E; Stumpf, I | 1 |
| Chattoraj, A; Maitra, SK; Seth, M | 1 |
| Gressens, P; Husson, I; Mocaer, E; Sarkozy, G; Schwendimann, L; Spedding, M; Vamecq, J | 1 |
| Añez, F; Bonilla, E; Chacin-Bonilla, L; Espina, LM; Maldonado, M; Meleán, E; Nery, A; Valero, N | 1 |
| Aras, HC; Ekström, J | 1 |
| Chan, KW; Liu, VW; Pang, B; Shiu, SY; Tam, CW; Yao, KM | 1 |
| Genade, S; Genis, A; Huisamen, B; Lochner, A; Ytrehus, K | 1 |
| Han, J; Shen, J; Wei, YM; Xu, Y; Yu, CX | 1 |
| Fujinoki, M | 1 |
| Kumar, S; Rai, U; Roy, B; Singh, R | 1 |
| Lahiri, S; Palit, G; Pant, KK; Rasheed, N; Singh, P; Singh, S | 1 |
| Carrillo-Vico, A; Guerrero, JM; Lardone, PJ; Molinero, P; Rubio, A | 1 |
| Babu, H; Benítez-King, G; Kempermann, G; Klempin, F; Ramírez-Rodríguez, G | 1 |
| Sampaio, Lde F | 1 |
| Ghibelli, L; Mengoni, F; Nuccitelli, S; Radogna, F | 1 |
| Brown, GM; Cardinali, DP; Moscovitch, A; Pandi-Perumal, SR; Spence, DW; Srinivasan, V; Trakht, I | 1 |
| Fuss-Chmielewska, J; Karasek, M; Lawnicka, H; Pawlikowski, M; Winczyk, K | 1 |
| Banik, NL; Das, A; McDowell, M; Pava, MJ; Ray, SK; Reiter, RJ; Smith, JA; Varma, AK; Woodward, JJ | 1 |
| Markus, RP; Sampaio, Lde F | 1 |
| Mickle, A; Miranda, A; Sengupta, JN; Shahmohammadi, G; Sood, M; Zhang, Z | 1 |
| Cheng, JC; Hung, WY; Lee, SK; Man, GC; Ng, BK; Ng, TB; Qiu, Y; Wang, WW; Wong, JH; Yeung, BH | 1 |
| Egea, J; García, AG; López, MG; Romero, A | 1 |
| Jaworek, J; Leja-Szpak, A; Pierzchalski, P; Reiter, RJ | 1 |
| Govitrapong, P; Phansuwan-Pujito, P; Sotthibundhu, A | 1 |
| Pang, B; Shiu, SY; Tam, CW; Yao, KM | 1 |
| Chen, C; Du, K; Huang, D; Liang, A; Peng, Y; Su, P; Xu, C; Zhang, L | 1 |
| Belle, MD; Delagrange, P; Piggins, HD; Scott, FF | 1 |
| Cevik-Aras, H; Ekström, J | 1 |
| Brodsky, VY; Dubovaya, ND; Fateeva, VI; Mal'chenko, LA; Zvezdina, TK | 1 |
| Burow, ME; Hill, SM; Jones, FE; Mao, L; Slakey, LM; Yuan, L | 1 |
| Alarma-Estrany, P; Guzman-Aranguez, A; Huete, F; Pelaez, T; Peral, A; Pintor, J; Plourde, R; Yerxa, B | 1 |
| Guerra, M; Pedreros, M; Ratto, M | 1 |
| Cevik-Aras, H; Ekstrom, J; Godoy, T | 1 |
| Cardaci, E; Colantuoni, A; Lapi, D; Paterni, M; Vagnani, S | 1 |
| Dash, D; Kumari, S | 1 |
| Alonso-González, C; Alvarez-García, V; Cos, S; González, A; Martínez-Campa, C | 1 |
| Bambico, FR; Domínguez-López, S; Gobbi, G; Labonté, B; Leyton, M; Mahar, I; Ochoa-Sánchez, R | 1 |
| Dehpour, AR; Hojati, A; Moezi, L; Shafaroodi, H | 1 |
| Howland, H; Li, T; Takagi, Y; Wahl, C | 1 |
| Ahmad, R; Gupta, S; Haldar, C | 1 |
| Levi, V; Pecci, A; Pignataro, OP; Presman, DM | 1 |
| Alcin, E; Ayar, A; Kacar, E; Kelestimur, H; Ozcan, M; Yılmaz, B | 1 |
| Cary, GA; Cuttler, AS; Duda, KA; Kusema, ET; Myers, JA; Tilden, AR | 1 |
| Ahmed, F; Mubashshir, MD; Ovais, M; Sumoona, S | 1 |
| Jee, HJ; Kim, AJ; Kim, HJ; Kim, M; Song, N; Yoo, YH; Yun, J | 1 |
| Ahmad, AH; Mohamed, M; Srinivasan, V; Zakaria, R | 1 |
| Albrecht, E; Bazwinsky-Wutschke, I; Mühlbauer, E; Peschke, E; Wolgast, S | 1 |
| Cheng, XP; Sun, H; Ye, ZY; Zhou, JN | 1 |
| Chen, M; Hu, DN; McCormick, SA; Roberts, JE; Rosen, RB; Walsh, J | 1 |
| Bedini, A; Comai, S; Fraschini, F; Gobbi, G; Mor, M; Ochoa-Sanchez, R; Rainer, Q; Rivara, S; Spadoni, G; Tarzia, G | 1 |
| Ben Soussia, I; Mies, F; Naeije, R; Shlyonsky, V | 1 |
| Nylander, O; Sjöblom, M; Sommansson, A | 1 |
| Gupta, S; Haldar, C | 1 |
| Ceballos, NR; Regueira, E; Sassone, AG; Scaia, MF; Volonteri, MC | 1 |
| Bahadir, GM; Berna, T; Berrak, Y; Can, E; Handan, K; Ipek, E; Umit, UM | 1 |
| Bedrosian, TA; Fonken, LK; Herring, KL; Nelson, RJ; Walton, JC; Weil, ZM | 1 |
| Adamczyk-Sowa, M; Bartosz, G; Pierzchala, K; Sadowska-Bartosz, I; Sowa, P; Zwirska-Korczala, K | 1 |
| Nylander, O; Saudi, WS; Sjöblom, M; Sommansson, A | 1 |
| Markus, RP; Pires-Lapa, MA; Salustiano, EM; Tamura, EK | 1 |
| Camacho, LE; Lemley, CO; Vonnahme, KA | 1 |
| Ciosek, J; Drobnik, J; Hrabec, E; Olczak, S; Owczarek, K; Piera, L; Tosik, D | 1 |
| Cai, S; Hu, X; Li, X; Yin, W | 1 |
| Fink, T; Glas, M; Kiefer, D; Kleber, A; Mathes, AM; Rensing, H; Reus, E; Volk, T; Wolf, A; Wolf, B; Wolff, M | 1 |
| Bae, JH; Bae, KC; Cho, HC; Im, SS; Na, AY; Park, JH; Shim, HM; Song, DK | 1 |
| Cao, J; Chen, Y; Dong, Y; Li, J; Wang, Z | 1 |
| Ciosek, J; Drobnik, J; Liberski, PP; Olczak, S; Piera, L; Szczepanowska, A; Tosik, D; Zielinska, A | 1 |
| Bustamante-García, R; Espejo-González, O; Gómez-Martínez, AE; Lira-Rocha, AS; Picazo, O | 1 |
| Chang, HM; Chen, KY; Chen, LY; Ho, WH; Hsu, WM; Liao, WC; Liu, CH; Wang, HP; Wu, TH | 1 |
| Dash, D; Haldar, C; Kumar Singh, S; Kumar Yadav, S | 1 |
| Laredo, SA; McMackin, MZ; Orr, VN; Trainor, BC | 1 |
| Enomoto, M; Furuyama, W; Kawai, S; Kawazu, S; Mikoshiba, K; Mossaad, E | 1 |
| Adamczyk-Sowa, M; Pierzchala, K; Sowa, P; Zwirska-Korczala, K | 1 |
| Fu, Y; Gao, C; He, C; Ji, P; Li, N; Li, Y; Liu, G; Tian, X; Wang, F; Zhang, L | 1 |
| Chen, CR; Chen, L; Cheng, NN; Huang, ZL; Laudon, M; Liu, YY; Qu, WM; Urade, Y; Yin, D | 1 |
| Alarma-Estrany, P; Carracedo, G; Crooke, A; Guzman-Aranguez, A; Mediero, A; Pelaez, T; Peral, A; Pintor, J | 1 |
| Cheng, L; Duan, W; Jin, Z; Meng, Q; Pei, H; Sun, Y; Wang, X; Yang, Y; Yu, L; Yu, S; Zhai, M; Zhang, H; Zhang, Y | 1 |
| Chel'naia, NA; Iasnetsov, VV; Ivanov, IuV; Karsanova, SK; Motin, VG | 1 |
| Mubashshir, M; Ovais, M; Srivastava, SK; Sumoona, S | 1 |
| del Mar Arriero, M; Monjo, M; Ramis, JM; Satué, M | 1 |
| Juszczak, M; Kowalczyk, E; Roszczyk, M; Stempniak, B | 1 |
| Niles, LP; Pan, Y | 1 |
| Benítez-King, G; Domínguez-Alonso, A; Solís-Chagoyán, H; Valdés-Tovar, M | 1 |
| Govitrapong, P; Wongprayoon, P | 1 |
| Adam, T; Lamont, K; Lecour, S; Nduhirabandi, F; Opie, LH; Thomas, DP | 1 |
| Andrews, MT; Ballinger, MA; Schwartz, C | 1 |
| Chen, H; Jang, L; Li, Z; Rui, BB; Wei, W; Xu, WP; Yang, JM | 1 |
| Bonior, J; Goralska, M; Jastrzebska, M; Jaworek, J; Leja-Szpak, A; Link-Lenczowski, P; Nawrot-Porabka, K; Pierzchalski, P | 1 |
| Ogiwara, K; Takahashi, T | 1 |
| Fonseca, B; Martínez-Águila, A; Pérez de Lara, MJ; Pintor, J | 1 |
| Cai, S; Hu, X; Laudon, M; Li, X; Li, Z; Yin, W; Zhang, S | 1 |
| Liu, B; Liu, C; Pang, M; Rong, L; Shu, T; Wang, J; Wang, X; Wu, T | 1 |
| Cao, J; Chen, F; Chen, Y; Dong, Y; Reheman, A; Wang, Z; Zhang, Y | 1 |
| Dowse, HB; Powers, E; VanKirk, T | 1 |
| Bodinga, BM; Chen, HL; Deng, HH; Han, ZS; He, YM; Jiang, ZL; Li, QW; Shi, MH | 1 |
| Li, W; Lv, J; Mao, C; Tao, J; Xu, Z; Zhang, P | 1 |
| Chen, Y; Dai, ZS; He, LJ; Huang, L; Ke, QF; Wu, JZ; Wu, WH | 1 |
| Govitrapong, P; Jumnongprakhon, P; Sivasinprasasn, S; Tocharus, C; Tocharus, J | 1 |
| Jiang, J; Jin, X; Lu, F; Ma, X; Xia, X; Yang, S; Zheng, C; Zhu, W | 1 |
| Chan, MTV; Li, X; Li, Z; Shen, J; Tan, D; Wu, WKK | 1 |
| Bi, Z; Bikkuzin, T; Cai, B; Cao, Y; Ding, F; Dong, C; Feng, C; Gong, R; Han, Z; Huang, Q; Idiiatullina, E; Li, Y; Liu, T; Pavlov, V; Wang, D; Wang, N; Yan, G; Yang, F; Yang, L; Yuan, Y; Zhang, L | 1 |
| Barberino, RS; Jiang, X; Matos, MHT; Menezes, VG; Palheta, RC; Ribeiro, AEAS; Smitz, JEJ | 1 |
| Chan, MTV; Chen, C; Li, X; Li, Z; Shen, J; Wu, WKK | 1 |
| Lemley, CO; Vonnahme, KA | 1 |
| Deng, SL; Lian, ZX; Liu, YX; Sun, TC; Wang, XX; Wang, ZP; Yu, K; Zhang, BL; Zhang, Y | 1 |
| Bu, Y; Fan, L; He, L; Liu, B; Liu, C; Pang, M; Rong, L; Shu, T; Wang, J; Wang, X; Wu, T | 1 |
| Azizi, M; Kashani, IR; Mokhtari, T; Nadji, SA; Omidi, N; Pasbakhsh, P; Pourabdollah, M; Sadr, M; Zendehdel, A | 1 |
| Acuña-Castroviejo, D; Antequera, D; Carro, E; de la Fuente Revenga, M; Figueiro-Silva, J; Pascual, C; Rodríguez-Franco, MI; Volt, H | 1 |
| Chen, ZJ; Li, H; Shi, F; Wang, E; Zhang, C | 1 |
| Li, R; Lv, Y; Zeng, W; Zhu, Z | 1 |
| Ikeuchi, T; Sakai, K; Yamamoto, Y | 1 |
| Fang, R; Guo, Y; Jin, T; Li, F; Li, Y; Liang, H; Shan, H; Su, X; Wang, Y; Yang, R; Zhang, L; Zhao, X | 1 |
| Bamba, D; Bi, Z; Cai, B; Ding, F; Feng, C; Fu, Y; Gao, M; Gong, R; He, M; Huang, Q; Jin, M; Li, Y; Liu, T; Ma, W; Reiters, R; Sukhareva, N; Sun, Y; Xu, C; Yan, G; Yang, F; Yang, L; Yuan, Y; Zhang, L | 1 |
| Aydin, L; Baltaci, AK; Mogulkoc, R | 1 |
| Andreeva-Gateva, P; Angelova, VT; Rangelov, M; Tchekalarova, J; Todorova, N | 1 |
| Heo, JS; Kim, BY; Kim, GJ; Kim, J; Kim, JH; Lee, SG; Lim, JY; Pyo, S; Yoon, DW | 1 |
| Fan, XY; Fei, GH; Wu, HM; Xie, QM; Xu, J; Zhao, CC | 1 |
| Huang, J; Li, L; Luo, Y; Shen, Y; Tang, L; Yang, Y; Zhang, L | 1 |
| Barbosa-Méndez, S; Salazar-Juárez, A | 1 |
| Qi, ZX; Wei, ZX; Zhou, N | 1 |
| Fischer-Sternjak, J; Gengatharan, A; Ghareghani, M; Götz, M; Malvaut, S; Marymonchyk, A; Ninkovic, J; Saghatelyan, A; Snapyan, M | 1 |
| Bruin, PFC; Bruin, VMS; Duarte, ASG; Matos, RS; Oriá, RB; Pinto, DV; Santos, FA; Viana, AFSC | 1 |
| Albeshr, MF; Alrefaei, AF; B, B; Karuppusamy, I; Kumar, TC; Kumarasamy, S; Muthusamy, R; Nhung, TC; Ramkumar, G | 1 |
| Azarov, JE; Bernikova, OG; Cuprova, J; Diez, ER; Durkina, AV; Gonotkov, MA; Prado, NJ; Sedova, KA; Szeiffova Bacova, B; Vaykshnorayte, MA | 1 |
5 review(s) available for luzindole and melatonin
| Article | Year |
|---|---|
Melatonin receptors in the central nervous system.
Topics: Animals; Brain Chemistry; Calcium; Chickens; Circadian Rhythm; Dopamine; Hypothalamus; Mammals; Melatonin; Mice; Mice, Inbred C3H; Periodicity; Pineal Gland; Receptors, Melatonin; Receptors, Neurotransmitter; Reproduction; Retina; Seasons; Suprachiasmatic Nucleus; Tryptamines | 1991 |
Molecular tools to study melatonin pathways and actions.
Topics: Animals; Antioxidants; Humans; Melatonin; Molecular Structure; Receptors, Melatonin; Signal Transduction; Tetrahydronaphthalenes; Tryptamines | 2005 |
Malaria: therapeutic implications of melatonin.
Topics: Animals; Antimalarials; Apoptosis; Humans; Malaria; Melatonin; Models, Biological; Plasmodium falciparum; Receptors, Melatonin; Tryptamines | 2010 |
Melatonin effects on Plasmodium life cycle: new avenues for therapeutic approach.
Topics: Animals; Antimalarials; Humans; Life Cycle Stages; Malaria, Falciparum; Melatonin; Plasmodium falciparum; Signal Transduction; Tryptamines | 2012 |
PHYSIOLOGY AND ENDOCRINOLOGY SYMPOSIUM: Alterations in uteroplacental hemodynamics during melatonin supplementation in sheep and cattle.
Topics: Animals; Antioxidants; Cattle; Diet; Dietary Supplements; Endocrinology; Female; Fetal Development; Fetus; Hemodynamics; Melatonin; Placenta; Pregnancy; Receptors, Melatonin; Sheep; Tryptamines; Umbilical Cord; Uterus | 2017 |
1 trial(s) available for luzindole and melatonin
| Article | Year |
|---|---|
Melatonin synthesis in human colostrum mononuclear cells enhances dectin-1-mediated phagocytosis by mononuclear cells.
Topics: Adolescent; Adult; Animals; Cell Line; Colostrum; DNA-Binding Proteins; Female; Humans; Infant, Newborn; Lectins, C-Type; Leukocytes, Mononuclear; Melatonin; Mice; Nuclear Proteins; Phagocytosis; Proto-Oncogene Proteins c-rel; Tetrahydronaphthalenes; Transcription Factor RelA; Tryptamines | 2013 |
223 other study(ies) available for luzindole and melatonin
| Article | Year |
|---|---|
Melatonin receptor antagonists that differentiate between the human Mel1a and Mel1b recombinant subtypes are used to assess the pharmacological profile of the rabbit retina ML1 presynaptic heteroreceptor.
Topics: Animals; Cell Line; Humans; In Vitro Techniques; Iodine Radioisotopes; Kinetics; Melatonin; Rabbits; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Receptors, Presynaptic; Recombinant Proteins; Retina | 1997 |
Mapping the melatonin receptor. 5. Melatonin agonists and antagonists derived from tetrahydrocyclopent[b]indoles, tetrahydrocarbazoles and hexahydrocyclohept[b]indoles.
Topics: Animals; Binding, Competitive; Brain; Carbazoles; Cell Membrane; Chickens; Crystallography, X-Ray; Indicators and Reagents; Indoles; Melanophores; Melatonin; Models, Molecular; Molecular Conformation; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Structure-Activity Relationship; Xenopus laevis | 1998 |
Pharmacological characterization of human recombinant melatonin mt(1) and MT(2) receptors.
Topics: Animals; Binding, Competitive; Cell Membrane; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Humans; Isotope Labeling; Kinetics; Melatonin; Pertussis Toxin; Radioligand Assay; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Recombinant Proteins; Virulence Factors, Bordetella | 2000 |
Mapping the melatonin receptor. 6. Melatonin agonists and antagonists derived from 6H-isoindolo[2,1-a]indoles, 5,6-dihydroindolo[2,1-a]isoquinolines, and 6,7-dihydro-5H-benzo[c]azepino[2,1-a]indoles.
Topics: 3T3 Cells; Animals; Binding, Competitive; Cyclic AMP; Humans; Indoles; Isoindoles; Melatonin; Mice; Pigments, Biological; Radioligand Assay; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Recombinant Proteins; Structure-Activity Relationship; Xenopus laevis | 2000 |
Three-dimensional quantitative structure-activity relationship studies on selected MT1 and MT2 melatonin receptor ligands: requirements for subtype selectivity and intrinsic activity modulation.
Topics: Ligands; Melatonin; Models, Molecular; Models, Statistical; Pyrroles; Quantitative Structure-Activity Relationship; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin | 2003 |
New selective ligands of human cloned melatonin MT1 and MT2 receptors.
Topics: Animals; Cell Line; CHO Cells; Cloning, Molecular; Cricetinae; Dose-Response Relationship, Drug; Humans; Ligands; Melatonin; Protein Binding; Receptor, Melatonin, MT1; Receptor, Melatonin, MT2 | 2003 |
Design, synthesis and melatoninergic activity of new unsubstituted and beta,beta'-difunctionalised 2,3-dihydro-1H-pyrrolo[3,2,1-ij]quinolin-6-alkanamides.
Topics: 3T3 Cells; Animals; Drug Design; Humans; Melanophores; Mice; Molecular Structure; Quinolines; Receptor, Melatonin, MT1; Receptor, Melatonin, MT2; Xenopus laevis | 2007 |
Design, synthesis, and melatoninergic activity of new azido- and isothiocyanato-substituted indoles.
Topics: Animals; Azides; Drug Design; Indoles; Isothiocyanates; Ligands; Melatonin; Receptors, Melatonin; Structure-Activity Relationship; Xenopus laevis | 2007 |
MT1 and MT2 melatonin receptors: ligands, models, oligomers, and therapeutic potential.
Topics: Animals; Binding Sites; Depressive Disorder; Humans; Ligands; Melatonin; Models, Molecular; Protein Multimerization; Receptor, Melatonin, MT1; Receptor, Melatonin, MT2; Sleep Initiation and Maintenance Disorders; Structure-Activity Relationship | 2014 |
New melatonin-N,N-dibenzyl(N-methyl)amine hybrids: potent neurogenic agents with antioxidant, cholinergic, and neuroprotective properties as innovative drugs for Alzheimer's disease.
Topics: Alzheimer Disease; Antioxidants; Blood-Brain Barrier; Cell Line; Cholinesterase Inhibitors; Humans; Inhibitory Concentration 50; Magnetic Resonance Spectroscopy; Melatonin; Neuroprotective Agents; Spectrometry, Mass, Electrospray Ionization | 2014 |
Novel N-Acetyl Bioisosteres of Melatonin: Melatonergic Receptor Pharmacology, Physicochemical Studies, and Phenotypic Assessment of Their Neurogenic Potential.
Topics: Animals; Cells, Cultured; CHO Cells; Cricetulus; Humans; Male; Melatonin; Models, Molecular; Neural Stem Cells; Neurogenesis; Oxadiazoles; Rats; Rats, Wistar; Receptors, Melatonin; Thiadiazoles | 2015 |
Fluorine substituted methoxyphenylalkyl amides as potent melatonin receptor agonists.
Topics: | 2019 |
Effect of putative melatonin receptor antagonists on melatonin-induced pigment aggregation in isolated Xenopus laevis melanophores.
Topics: Animals; Cell Aggregation; Dose-Response Relationship, Drug; Melanophores; Melatonin; Pigmentation; Receptors, Melatonin; Receptors, Neurotransmitter; Tryptamines; Xenopus laevis | 1992 |
Effects of melatonin agonists and antagonists on reproduction and body weight in the Siberian hamster.
Topics: Animals; Binding, Competitive; Body Weight; Cricetinae; Light; Male; Median Eminence; Melatonin; Methysergide; Organ Size; Periodicity; Pituitary Gland, Anterior; Receptors, Melatonin; Receptors, Neurotransmitter; Testis; Tryptamines | 1990 |
Activation of melatonin receptor sites retarded the depletion of norepinephrine following inhibition of synthesis in the C3H/HeN mouse hypothalamus.
Topics: alpha-Methyltyrosine; Animals; Brain; Circadian Rhythm; Hypothalamus; Male; Melatonin; Methyltyrosines; Mice; Mice, Inbred C3H; Norepinephrine; Receptors, Melatonin; Receptors, Neurotransmitter; Tissue Distribution; Tryptamines | 1990 |
Antidepressant-like activity of the melatonin receptor antagonist, luzindole (N-0774), in the mouse behavioral despair test.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Calcium; Cerebral Cortex; Desipramine; Dose-Response Relationship, Drug; Male; Melatonin; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Motor Activity; Norepinephrine; Receptors, Melatonin; Receptors, Neurotransmitter; Tryptamines | 1990 |
Luzindole (N-0774): a novel melatonin receptor antagonist.
Topics: Animals; Apomorphine; Binding, Competitive; Calcium; Clonidine; Dopamine; Electric Stimulation; Melatonin; Rabbits; Receptors, Melatonin; Receptors, Neurotransmitter; Retina; Tryptamines | 1988 |
Melatonin receptor-mediated inhibition of cyclic AMP accumulation in chick retinal cell cultures.
Topics: 1-Methyl-3-isobutylxanthine; 5-Methoxytryptamine; Animals; Cells, Cultured; Chick Embryo; Colforsin; Cyclic AMP; Iodine Radioisotopes; Melatonin; Neurons; Pertussis Toxin; Photoreceptor Cells; Potassium; Receptors, Cell Surface; Receptors, Melatonin; Retina; Second Messenger Systems; Structure-Activity Relationship; Tryptamines; Virulence Factors, Bordetella | 1994 |
Melatonin receptors mediate potentiation of contractile responses to adrenergic nerve stimulation in rat caudal artery.
Topics: Animals; Arteries; Electric Stimulation; In Vitro Techniques; Isometric Contraction; Ketanserin; Male; Melatonin; Muscle Contraction; Muscle, Smooth, Vascular; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Receptors, Melatonin; Regional Blood Flow; Serotonin; Sympathetic Nervous System; Tail; Tryptamines; Vasoconstriction | 1995 |
Thermodynamic analysis of agonist and antagonist binding to the chicken brain melatonin receptor.
Topics: Animals; Binding Sites; Brain; Chickens; Guanosine Triphosphate; Iodine Radioisotopes; Kinetics; Melatonin; Receptors, Cell Surface; Receptors, Melatonin; Regression Analysis; Temperature; Thermodynamics; Tryptamines | 1994 |
Modulation of the rat suprachiasmatic circadian clock by melatonin in vitro.
Topics: Action Potentials; Animals; Circadian Rhythm; In Vitro Techniques; Male; Melatonin; Neurons; Rats; Suprachiasmatic Nucleus; Tryptamines | 1995 |
Characterization and regulation of the human ML1A melatonin receptor stably expressed in Chinese hamster ovary cells.
Topics: Animals; Binding, Competitive; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Humans; Kinetics; Melatonin; Receptors, Cell Surface; Receptors, Melatonin; Recombinant Proteins; Transfection; Tryptamines | 1996 |
Identification of Mel1a melatonin receptors in the human embryonic kidney cell line HEK293: evidence of G protein-coupled melatonin receptors which do not mediate the inhibition of stimulated cyclic AMP levels.
Topics: Binding, Competitive; Cell Line; Colforsin; Cyclic AMP; Genomic Library; GTP-Binding Proteins; Humans; Kidney; Melatonin; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; RNA, Messenger; Sequence Analysis, DNA; Serotonin; Signal Transduction; Tryptamines | 1997 |
Melatonin directly constricts rat cerebral arteries through modulation of potassium channels.
Topics: Animals; Apamin; Benzimidazoles; Cerebral Arteries; Charybdotoxin; GTP-Binding Proteins; Ketanserin; Male; Melatonin; Muscle Contraction; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Pertussis Toxin; Potassium; Potassium Channels; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Tetraethylammonium; Tetraethylammonium Compounds; Tryptamines; Vasoconstriction; Virulence Factors, Bordetella | 1997 |
Melatonin facilitates short-term memory.
Topics: Animals; Injections, Intraventricular; Male; Melatonin; Memory; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Social Behavior; Tryptamines | 1998 |
Selective MT2 melatonin receptor antagonists block melatonin-mediated phase advances of circadian rhythms.
Topics: Animals; Base Sequence; CHO Cells; Circadian Rhythm; Cricetinae; Darkness; Humans; Male; Melatonin; Mice; Mice, Inbred C3H; Motor Activity; Oligonucleotides, Antisense; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Tetrahydronaphthalenes; Transfection; Tryptamines | 1998 |
The melatonin antagonist luzindole protects retinal photoreceptors from light damage in the rat.
Topics: Animals; Dark Adaptation; Electroretinography; Light; Male; Melatonin; Photoreceptor Cells; Radiation Injuries, Experimental; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Retinal Degeneration; Tryptamines | 1998 |
Comparison of the structure-activity relationships of melatonin receptor agonists and antagonists: lengthening the N-acyl side-chain has differing effects on potency on Xenopus melanophores.
Topics: 3T3 Cells; Animals; Binding, Competitive; COS Cells; Melanophores; Melanosomes; Melatonin; Mice; Radioligand Assay; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Structure-Activity Relationship; Tryptamines; Xenopus laevis | 1998 |
Vasoconstrictor effects of various melatonin analogs on the rat tail artery in the presence of phenylephrine.
Topics: Acetamides; Animals; Dose-Response Relationship, Drug; Drug Interactions; Endothelium; Male; Melatonin; Muscle, Smooth; Nerve Endings; Norepinephrine; Perfusion; Phenylephrine; Rats; Rats, Wistar; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sympathetic Nervous System; Tail; Tryptamines; Vasoconstriction | 1999 |
Mechanisms of melatonin-induced vasoconstriction in the rat tail artery: a paradigm of weak vasoconstriction.
Topics: Acetamides; Animals; Anticonvulsants; Arteries; Calcium Channel Blockers; Charybdotoxin; Colforsin; Dose-Response Relationship, Drug; Hypnotics and Sedatives; In Vitro Techniques; Indoles; Male; Melatonin; Nifedipine; Nitroprusside; Potassium Channels; Rats; Rats, Sprague-Dawley; Tail; Tryptamines; Vasoconstriction; Vasoconstrictor Agents; Vasodilator Agents; Vasopressins | 1999 |
Characterization of membrane melatonin receptor in mouse peritoneal macrophages: inhibition of adenylyl cyclase by a pertussis toxin-sensitive G protein.
Topics: Adenosine Diphosphate Ribose; Adenylate Cyclase Toxin; Adenylyl Cyclase Inhibitors; Animals; Blotting, Western; Colforsin; Cyclic AMP; GTP-Binding Protein alpha Subunits, Gi-Go; Iodine Radioisotopes; Kinetics; Macrophages, Peritoneal; Melatonin; Mice; Neuroimmunomodulation; Pertussis Toxin; Radioligand Assay; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Serotonin; Signal Transduction; Tryptamines; Virulence Factors, Bordetella | 1999 |
Ligand efficacy and potency at recombinant human MT2 melatonin receptors: evidence for agonist activity of some mt1-antagonists.
Topics: 3T3 Cells; Animals; Dose-Response Relationship, Drug; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Melatonin; Mice; Pertussis Toxin; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Recombinant Proteins; Tryptamines; Virulence Factors, Bordetella | 1999 |
Effects of melatonin on rat pial arteriolar diameter in vivo.
Topics: Algorithms; Animals; Antioxidants; Arterioles; Benzimidazoles; Dose-Response Relationship, Drug; Enzyme Inhibitors; Male; Melatonin; Muscle Contraction; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide Donors; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Penicillamine; Pia Mater; Potassium Channels; Rats; Rats, Wistar; Regional Blood Flow; S-Nitroso-N-Acetylpenicillamine; Tetraethylammonium; Tryptamines | 1999 |
Acute low doses of melatonin stimulate rat sex behavior: the role of serotonin neurotransmission.
Topics: Amphetamines; Animals; Dose-Response Relationship, Drug; Ejaculation; Female; Injections, Intraperitoneal; Male; Melatonin; Rats; Rats, Wistar; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Receptors, Serotonin; Serotonin; Serotonin Receptor Agonists; Sexual Behavior, Animal; Synaptic Transmission; Tryptamines | 1999 |
Selective MT(2) melatonin receptor antagonist blocks melatonin-induced antinociception in rats.
Topics: Analgesics; Animals; Injections, Intraventricular; Male; Melatonin; Pain Measurement; Pain Threshold; Prazosin; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Tryptamines | 2000 |
Melatonin reversal of DOI-induced hypophagia in rats; possible mechanism by suppressing 5-HT(2A) receptor-mediated activation of HPA axis.
Topics: Adrenal Glands; Amphetamines; Animals; Anorexia; Ascorbic Acid; Exploratory Behavior; Feeding Behavior; Fever; Gastrointestinal Transit; Hypothalamo-Hypophyseal System; Injections, Intraperitoneal; Injections, Intraventricular; Male; Melatonin; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT2A; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Receptors, Serotonin; Ritanserin; Serotonin Antagonists; Suprachiasmatic Nucleus; Tryptamines | 2000 |
A neuroendocrine releasing effect of melatonin in the brain of an insect, Periplaneta americana (L.).
Topics: Animals; Brain; Dose-Response Relationship, Drug; Ecdysterone; Endocrine Glands; Free Radical Scavengers; Insect Hormones; Melatonin; Neuropeptides; Periplaneta; Radioimmunoassay; Serotonin; Tryptamines | 2000 |
Evidence for a melatonin receptor within pancreatic islets of neonate rats: functional, autoradiographic, and molecular investigations.
Topics: Animals; Animals, Newborn; Autoradiography; Colforsin; DNA Primers; Dose-Response Relationship, Drug; Female; Gene Expression; Guanosine 5'-O-(3-Thiotriphosphate); Insulin; Insulin Secretion; Islets of Langerhans; Male; Melatonin; Rats; Rats, Wistar; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tryptamines | 2000 |
Differential growth inhibitory effect of melatonin on two endometrial cancer cell lines.
Topics: Adenocarcinoma; Antineoplastic Agents; Cell Count; Cell Division; Endometrial Neoplasms; Estradiol; Female; Humans; Melatonin; Neoplasms, Hormone-Dependent; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Estrogen; Receptors, Melatonin; Tryptamines; Tumor Cells, Cultured | 2000 |
Calcium-dependent modulation by melatonin of the circadian rhythm in malarial parasites.
Topics: Animals; Calcium; Circadian Rhythm; Dose-Response Relationship, Drug; Estrenes; Female; Malaria; Melatonin; Mice; Mice, Inbred BALB C; Pineal Gland; Plasmodium chabaudi; Plasmodium falciparum; Pyrrolidinones; Thapsigargin; Tryptamines | 2000 |
Acute low doses of melatonin restore full sexual activity in impotent male rats.
Topics: Amphetamines; Amygdala; Animals; Dose-Response Relationship, Drug; Ejaculation; Erectile Dysfunction; Hypothalamus; Injections; Male; Melatonin; Rats; Rats, Wistar; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Serotonin; Serotonin Receptor Agonists; Sexual Behavior, Animal; Time Factors; Tryptamines | 2000 |
Activation of MT(2) melatonin receptors in rat suprachiasmatic nucleus phase advances the circadian clock.
Topics: Action Potentials; Animals; Biological Clocks; Circadian Rhythm; Iodine Radioisotopes; Male; Melatonin; Neurons; Oligoribonucleotides, Antisense; Protein Kinase C; Radioligand Assay; Rats; Rats, Long-Evans; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Suprachiasmatic Nucleus; Tetrahydronaphthalenes; Tryptamines | 2001 |
Melatonin inhibits Arg-vasopressin release via MT(2) receptor in the suprachiasmatic nucleus-slice culture of rats.
Topics: Animals; Antioxidants; Arginine Vasopressin; Circadian Rhythm; Dose-Response Relationship, Drug; Melatonin; Motor Activity; Organ Culture Techniques; Photoperiod; Rats; Rats, Wistar; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Suprachiasmatic Nucleus; Tryptamines | 2001 |
Disruption of mitochondrial respiration by melatonin in MCF-7 cells.
Topics: Adenocarcinoma; Adenosine Triphosphate; Antioxidants; Breast Neoplasms; Cell Respiration; Electron Transport Complex IV; Female; GTP-Binding Proteins; Humans; Luminescent Measurements; Melatonin; Microscopy, Electron; Mitochondria; Oxygen Consumption; Polarography; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Succinate Dehydrogenase; Thymidine; Tryptamines; Tumor Cells, Cultured | 2001 |
The modulation of neuronal activity by melatonin: in vitro studies on mouse hippocampal slices.
Topics: Animals; Dose-Response Relationship, Drug; Evoked Potentials; Female; Hippocampus; Male; Melatonin; Mice; Neurons; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Tryptamines | 2001 |
Involvement of melatonin MT(3) receptors in the regulation of intraocular pressure in rabbits.
Topics: Animals; Dose-Response Relationship, Drug; Intraocular Pressure; Male; Melatonin; Rabbits; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Time Factors; Tryptamines | 2001 |
Melatonin enhancement of splenocyte proliferation is attenuated by luzindole, a melatonin receptor antagonist.
Topics: Animals; Cell Division; Cells, Cultured; Circadian Rhythm; Concanavalin A; Darkness; Light; Lymphocyte Activation; Male; Melatonin; Mice; Mice, Inbred C57BL; Photoperiod; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Spleen; T-Lymphocytes; Tryptamines | 2001 |
Serine residues 110 and 114 are required for agonist binding but not antagonist binding to the melatonin MT(1) receptor.
Topics: Acetamides; Amides; Amino Acid Substitution; Animals; Binding Sites; Binding, Competitive; COS Cells; Cyclic AMP; Dose-Response Relationship, Drug; Heterotrimeric GTP-Binding Proteins; Humans; Indoles; Melatonin; Mutagenesis, Site-Directed; Naphthalenes; Protein Binding; Radioligand Assay; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Recombinant Fusion Proteins; Serine; Structure-Activity Relationship; Transfection; Tryptamines | 2001 |
Food intake inhibition by melatonin in goldfish (Carassius auratus).
Topics: Animals; Antioxidants; Depression, Chemical; Eating; Goldfish; Injections, Intraperitoneal; Injections, Intraventricular; Melatonin; Tryptamines | 2001 |
Reversal of reserpine-induced vacuous chewing movements in rats by melatonin: involvement of peripheral benzodiazepine receptors.
Topics: Adrenergic alpha-Antagonists; Adrenergic Uptake Inhibitors; Animals; Antineoplastic Agents; Dose-Response Relationship, Drug; Drug Interactions; Dyskinesia, Drug-Induced; Flumazenil; GABA Modulators; GABA-A Receptor Agonists; gamma-Aminobutyric Acid; Isoquinolines; Male; Mastication; Melatonin; Neostriatum; Prazosin; Rats; Rats, Wistar; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, GABA-A; Receptors, Melatonin; Reserpine; Tryptamines | 2001 |
Melatonin reduces anxiety induced by lipopolysaccharide in the rat.
Topics: Animals; Anxiety; Bacterial Infections; Behavior, Animal; Brain; Circadian Rhythm; Dose-Response Relationship, Drug; Drug Interactions; Endotoxins; Lipopolysaccharides; Male; Maze Learning; Melatonin; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Tryptamines | 2001 |
Peripheral melatonin mediates neural stimulation of duodenal mucosal bicarbonate secretion.
Topics: Adrenocorticotropic Hormone; Animals; Bicarbonates; Blood Pressure; Circadian Rhythm; Corticotropin-Releasing Hormone; Duodenum; Enterochromaffin Cells; gamma-MSH; Hypophysectomy; Injections, Intra-Arterial; Injections, Intraventricular; Intestinal Mucosa; Melatonin; Neurosecretion; Phenylephrine; Pineal Gland; Prazosin; Protein Isoforms; Rats; Rats, Inbred Lew; Rats, Sprague-Dawley; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Tetrahydronaphthalenes; Thiopental; Tryptamines; Vagotomy | 2001 |
Melatonin receptor subtype MT2 (Mel 1b) and not mt1 (Mel 1a) is associated with melatonin-induced enhancement of cell-mediated and humoral immunity.
Topics: Animals; Antibody Formation; Cell Division; Immunity; Immunity, Cellular; Male; Melatonin; Mice; Mice, Knockout; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Reference Values; Spleen; Tryptamines | 2001 |
Melatonin increases pial artery tone and decreases the lower limit of cerebral blood flow autoregulation.
Topics: Animals; Cerebral Arteries; Cerebrovascular Circulation; Free Radical Scavengers; Homeostasis; Infusions, Intravenous; Male; Melatonin; Pia Mater; Rats; Rats, Wistar; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Tryptamines; Vasodilation | 2001 |
Cyclical regulation of GnRH gene expression in GT1-7 GnRH-secreting neurons by melatonin.
Topics: Animals; Base Sequence; Cell Line; Circadian Rhythm; Enhancer Elements, Genetic; Gene Expression; Gonadotropin-Releasing Hormone; Melatonin; Mice; Molecular Sequence Data; Neurons; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; RNA, Messenger; Transcription, Genetic; Tryptamines | 2001 |
Melatonin-induced suppression of PC12 cell growth is mediated by its Gi coupled transmembrane receptors.
Topics: Adenylate Cyclase Toxin; Animals; Cyclic AMP-Dependent Protein Kinases; Growth Inhibitors; GTP-Binding Protein alpha Subunits, Gi-Go; Melatonin; PC12 Cells; Pertussis Toxin; Rats; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Tryptamines; Virulence Factors, Bordetella; Vitamin D | 2001 |
Melatonin and N-acetylserotonin inhibit leukocyte rolling and adhesion to rat microcirculation.
Topics: Animals; Arterioles; Blood Flow Velocity; Cell Adhesion; Dose-Response Relationship, Drug; Leukocytes; Male; Melatonin; Microcirculation; Rats; Rats, Wistar; Serotonin; Tetrahydronaphthalenes; Tryptamines | 2001 |
Effects of microinjection of melatonin and its receptor antagonists into anterior hypothalamic area on blood pressure and heart rate in rats.
Topics: Animals; Anterior Hypothalamic Nucleus; Blood Pressure; Heart Rate; Male; Melatonin; Microinjections; Prazosin; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Tryptamines | 2001 |
Melatoninergic neuroprotection of the murine periventricular white matter against neonatal excitotoxic challenge.
Topics: Animals; Animals, Newborn; Antioxidants; Cell Death; Cerebral Palsy; Cystine; Denervation; Disease Models, Animal; Excitatory Amino Acid Agonists; Free Radical Scavengers; Humans; Hypothermia, Induced; Ibotenic Acid; Infant, Newborn; Leukomalacia, Periventricular; Melatonin; Mice; Mice, Inbred C57BL; Mice, Transgenic; Neocortex; Neuroprotective Agents; Neurotoxins; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; RNA, Messenger; Tetrahydronaphthalenes; Tryptamines | 2002 |
Melatonin receptors in rat hippocampus: molecular and functional investigations.
Topics: Animals; Circadian Rhythm; Electrophysiology; Hippocampus; Male; Melatonin; Membrane Potentials; Oocytes; Organ Culture Techniques; Rats; Rats, Wistar; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tetrahydronaphthalenes; Tryptamines; Xenopus | 2002 |
Influence of melatonin on chicken lymphocytes in vitro: involvement of membrane receptors.
Topics: Animals; Antioxidants; Cell Division; Cell Membrane; Cells, Cultured; Chickens; Colforsin; Cyclic AMP; Lymphocytes; Male; Melatonin; Phytohemagglutinins; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Signal Transduction; Spleen; Tryptamines | 2002 |
Role of prostaglandins, nitric oxide, sensory nerves and gastrin in acceleration of ulcer healing by melatonin and its precursor, L-tryptophan.
Topics: Actins; Animals; Capsaicin; Dinoprostone; Enzyme Inhibitors; Gastric Mucosa; Gastrins; Male; Melatonin; Neurons, Afferent; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Prostaglandins; Rats; Rats, Wistar; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Regional Blood Flow; Stomach Ulcer; Tryptamines; Tryptophan | 2002 |
Receptor-mediated modulation of avian caecal muscle contraction by melatonin: role of tyrosine protein kinase.
Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Animals; Apamin; Binding, Competitive; Cecum; Dose-Response Relationship, Drug; Enzyme Inhibitors; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Triphosphate; Indoles; Melatonin; Muscle Contraction; Muscle, Smooth; Naphthalenes; Potassium Channels; Protein-Tyrosine Kinases; Quail; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Tetrahydronaphthalenes; Tryptamines | 2002 |
Receptor (MT(1)) mediated influence of melatonin on cAMP concentration and insulin secretion of rat insulinoma cells INS-1.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Biological Transport; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Insulin; Insulin Secretion; Insulinoma; Islets of Langerhans; Melatonin; Pancreatic Neoplasms; Phosphodiesterase Inhibitors; Polymerase Chain Reaction; Probenecid; Rats; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Signal Transduction; Tryptamines; Tumor Cells, Cultured | 2002 |
Small doses of melatonin increase intestinal motility in rats.
Topics: Animals; Atropine; Gastrointestinal Motility; Male; Melatonin; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Stimulation, Chemical; Tryptamines | 2002 |
Role of endogenous melatonin and its MT2 receptor in the modulation of caerulein-induced pancreatitis in the rat.
Topics: Amylases; Animals; Ceruletide; Dose-Response Relationship, Drug; Lipase; Lipid Peroxidation; Male; Melatonin; Organ Size; Pancreas; Pancreatitis; Rats; Rats, Wistar; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Tryptamines; Tumor Necrosis Factor-alpha | 2002 |
Melatonin modulates the light-induced sympathoexcitation and vagal suppression with participation of the suprachiasmatic nucleus in mice.
Topics: Animals; Anticonvulsants; Circadian Rhythm; Denervation; Injections, Intraventricular; Male; Melatonin; Mice; Mice, Inbred BALB C; Photic Stimulation; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Suprachiasmatic Nucleus; Sympathetic Nervous System; Tryptamines; Vagus Nerve | 2003 |
Short-term exposure to melatonin differentially affects the functional sensitivity and trafficking of the hMT1 and hMT2 melatonin receptors.
Topics: Animals; Arrestin; CHO Cells; Cricetinae; Humans; Iodine Radioisotopes; Melatonin; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Tetrahydronaphthalenes; Transfection; Tryptamines | 2003 |
Melatonin biological activity and binding sites in human melanoma cells.
Topics: Binding Sites; Binding, Competitive; Cell Division; Humans; Iodine Radioisotopes; Melanoma; Melatonin; Monophenol Monooxygenase; Prazosin; Serotonin; Tryptamines; Tumor Cells, Cultured | 2003 |
Melatonin in the duodenal lumen is a potent stimulant of mucosal bicarbonate secretion.
Topics: Animals; Bicarbonates; Domperidone; Dopamine Antagonists; Duodenum; Ganglionic Blockers; Hexamethonium; Intestinal Mucosa; Male; Melatonin; Perfusion; Rats; Rats, Inbred Strains; Receptor, Melatonin, MT2; Tryptamines | 2003 |
Melatonin enhances lymphocyte proliferation and decreases the release of pituitary pro-opiomelanocortin-derived peptides in surgically traumatized rats.
Topics: Adrenocorticotropic Hormone; Animals; Antioxidants; beta-Endorphin; Cell Division; Culture Media, Conditioned; Dose-Response Relationship, Drug; Drug Interactions; Enzyme-Linked Immunosorbent Assay; In Vitro Techniques; Lymphocytes; Male; Melatonin; Pituitary Gland; Rats; Rats, Sprague-Dawley; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Spleen; Tryptamines; Wounds and Injuries | 2003 |
Melatonin binding sites in estrogen receptor-positive cells derived from human endometrial cancer.
Topics: Binding Sites; Endometrial Neoplasms; Endometrium; Female; Humans; Melatonin; Receptors, Estrogen; Receptors, Melatonin; Time Factors; Tryptamines; Tumor Cells, Cultured | 2003 |
Diurnal actions of melatonin on epileptic activity in hippocampal slices of rats.
Topics: Animals; Bicuculline; Circadian Rhythm; Electroencephalography; Epilepsy; GABA Antagonists; Hippocampus; In Vitro Techniques; Magnesium; Melatonin; Membrane Potentials; Pyramidal Cells; Rats; Rats, Wistar; Tryptamines | 2003 |
Melatonin attenuates rat carotid chemoreceptor response to hypercapnic acidosis.
Topics: Acidosis, Respiratory; Animals; Calcium; Carotid Body; Chemoreceptor Cells; Electrophysiology; Fura-2; Hypercapnia; Melatonin; Rats; Rats, Sprague-Dawley; Receptor, Melatonin, MT1; Receptor, Melatonin, MT2; Receptors, Melatonin; Tetrahydronaphthalenes; Tryptamines | 2004 |
Characterization of melatonin binding sites in the brain and retina of the frog Rana perezi.
Topics: Animals; Binding Sites; Binding, Competitive; Brain; Cell Membrane; Diencephalon; Guanosine 5'-O-(3-Thiotriphosphate); Intracellular Membranes; Kinetics; Magnesium; Melatonin; Pertussis Toxin; Radioligand Assay; Ranidae; Receptors, Melatonin; Retina; Sodium; Subcellular Fractions; Superior Colliculi; Telencephalon; Tetrahydronaphthalenes; Tryptamines | 2004 |
Melatonin and its precursor, L-tryptophan: influence on pancreatic amylase secretion in vivo and in vitro.
Topics: Amylases; Animals; Benzodiazepines; Capsaicin; Cells, Cultured; Cholecystokinin; Devazepide; Dose-Response Relationship, Drug; Melatonin; Pancreas; Pancreatic Juice; Rats; Rats, Wistar; Receptors, Melatonin; Tryptamines; Tryptophan; Vagotomy; Vagus Nerve | 2004 |
Effect of melatonin on the oxidative stress in N1E-115 cells is not mediated by mt1 receptors.
Topics: Animals; Cell Line, Tumor; Enzyme Inhibitors; Lipid Peroxidation; Melatonin; Mice; Neuroblastoma; Okadaic Acid; Oxidative Stress; Receptor, Melatonin, MT1; Tryptamines | 2003 |
In vivo activation of insulin receptor tyrosine kinase by melatonin in the rat hypothalamus.
Topics: Animals; Dose-Response Relationship, Drug; Hypothalamus; Injections, Intraventricular; Insulin; Insulin Receptor Substrate Proteins; Intracellular Signaling Peptides and Proteins; Male; Melatonin; Mitogen-Activated Protein Kinase 1; Phosphatidylinositol 3-Kinases; Phosphoproteins; Phosphorylation; Protein Binding; Protein Serine-Threonine Kinases; Protein Tyrosine Phosphatase, Non-Receptor Type 11; Protein Tyrosine Phosphatases; Protein-Tyrosine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Receptors, Melatonin; Tetrahydronaphthalenes; Tryptamines | 2004 |
Diurnal changes of tonic nociceptive responses in mice: evidence for a proalgesic role of melatonin.
Topics: Animals; Autoradiography; Behavior, Animal; Binding Sites; Circadian Rhythm; Formaldehyde; Grooming; In Vitro Techniques; Iodine Isotopes; Male; Melatonin; Mice; Mice, Inbred CBA; Motor Activity; Pain; Pain Measurement; Pineal Gland; Receptors, Melatonin; Spinal Cord; Tryptamines | 2004 |
Intracellular second messengers involved in melatonin signal transduction in chicken splenocytes in vitro.
Topics: Animals; Cell Proliferation; Cells, Cultured; Chickens; Colforsin; Cyclic AMP; Inositol 1,4,5-Trisphosphate; Male; Melatonin; Receptor, Melatonin, MT2; Receptors, Melatonin; Second Messenger Systems; Signal Transduction; Spleen; Tetrahydronaphthalenes; Tryptamines | 2004 |
Direct effect of melatonin on Syrian hamster testes: melatonin subtype 1a receptors, inhibition of androgen production, and interaction with the local corticotropin-releasing hormone system.
Topics: 3-Hydroxysteroid Dehydrogenases; Androgens; Animals; Corticotropin-Releasing Hormone; Cricetinae; Cyclic AMP; DNA Primers; Immunoblotting; Immunoenzyme Techniques; Immunohistochemistry; Leydig Cells; Light; Male; Melatonin; Mesocricetus; Receptors, Melatonin; Reverse Transcriptase Polymerase Chain Reaction; Testis; Testosterone; Time Factors; Tryptamines | 2005 |
Human lymphocyte-synthesized melatonin is involved in the regulation of the interleukin-2/interleukin-2 receptor system.
Topics: Adult; Cells, Cultured; Gene Expression Regulation; Humans; Interleukin-2; Lymphocytes; Melatonin; Middle Aged; Receptors, Interleukin-2; Receptors, Melatonin; Tryptamines | 2005 |
Melatonin enhances leptin expression by rat adipocytes in the presence of insulin.
Topics: Adipocytes; Animals; Colforsin; Dexamethasone; Dose-Response Relationship, Drug; Drug Interactions; Gene Expression; Glucocorticoids; Inhibitory Concentration 50; Insulin; Leptin; Male; Melatonin; Pertussis Toxin; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Receptor, Insulin; Receptor, Melatonin, MT1; Reverse Transcriptase Polymerase Chain Reaction; RNA; Tryptamines | 2005 |
Exposure to continuous darkness ameliorates gastric and colonic inflammation in the rat: both receptor and non-receptor-mediated processes.
Topics: Acetic Acid; Animals; Colitis; Darkness; Ethanol; Female; Gastric Mucosa; Inflammation; Intestinal Mucosa; Light; Male; Melatonin; Oxidative Stress; Rats; Rats, Wistar; Receptor, Melatonin, MT2; Stomach Ulcer; Tryptamines | 2005 |
Melatonin enhances the hypoxic response of rat carotid body chemoreceptor.
Topics: Animals; Calcium; Carotid Body; Chemoreceptor Cells; Circadian Rhythm; Hypoxia; In Vitro Techniques; Melatonin; Rats; Rats, Sprague-Dawley; Receptors, Melatonin; Respiration; Tetrahydronaphthalenes; Tryptamines | 2005 |
Melatonin-induced modulation of glucose metabolism in primary cultures of rabbit kidney-cortex tubules.
Topics: Alanine; Animals; Diabetes Mellitus; Fructose-Bisphosphatase; Gluconeogenesis; Glucose; Glycerol; Insulin; Kidney Cortex; Kidney Tubules; Kinetics; Lactic Acid; Melatonin; Rabbits; Receptor, Melatonin, MT1; Tissue Culture Techniques; Tryptamines | 2005 |
Influence of melatonin on the development of functional nicotinic acetylcholine receptors in cultured chick retinal cells.
Topics: Animals; Bungarotoxins; Cells, Cultured; Chick Embryo; Immunohistochemistry; Melatonin; Microchemistry; Nicotinic Antagonists; Receptors, Nicotinic; Retina; Time Factors; Tryptamines | 2005 |
Melatonin synthesized by Jurkat human leukemic T cell line is implicated in IL-2 production.
Topics: Acetylserotonin O-Methyltransferase; Arylalkylamine N-Acetyltransferase; Dinoprostone; Enzyme Inhibitors; Humans; Interleukin-2; Jurkat Cells; Lymphocytes; Melatonin; Phytohemagglutinins; Receptors, Melatonin; RNA, Messenger; Tryptamines | 2006 |
The antidepressant-like effect of the melatonin receptor ligand luzindole in mice during forced swimming requires expression of MT2 but not MT1 melatonin receptors.
Topics: Animals; Antidepressive Agents; Ligands; Melatonin; Mice; Mice, Inbred C3H; Mice, Knockout; Receptor, Melatonin, MT1; Receptor, Melatonin, MT2; Swimming; Tryptamines | 2005 |
Modulation by melatonin of glutamatergic synaptic transmission in the carp retina.
Topics: Animals; Carps; Cyclic GMP; Dose-Response Relationship, Drug; Glutamic Acid; In Vitro Techniques; Light; Melatonin; Membrane Potentials; Receptor, Melatonin, MT1; Receptors, Glutamate; Retina; Retinal Cone Photoreceptor Cells; Retinal Horizontal Cells; Synaptic Transmission; Tryptamines; Vision, Ocular | 2005 |
Melatonin inhibits hippocampal long-term potentiation.
Topics: Animals; Antioxidants; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Electric Stimulation; Excitatory Postsynaptic Potentials; Hippocampus; In Vitro Techniques; Isoquinolines; Long-Term Potentiation; Male; Melatonin; Mice; Mice, Inbred C57BL; Mice, Knockout; Protein Kinase Inhibitors; Receptor, Melatonin, MT1; Receptor, Melatonin, MT2; Sulfonamides; Synaptic Transmission; Tryptamines | 2005 |
Short- and long-term effects of melatonin on myocardial post-ischemic recovery.
Topics: Animals; Cardiotonic Agents; In Vitro Techniques; Male; Melatonin; Myocardial Contraction; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion Injury; Perfusion; Rats; Rats, Wistar; Receptors, Melatonin; Tryptamines | 2006 |
Melatonin affects the immobility time of rats in the forced swim test: the role of serotonin neurotransmission.
Topics: Animals; Antidepressive Agents; Behavior, Animal; Clomipramine; Dose-Response Relationship, Drug; Drug Administration Routes; Drug Interactions; Immobility Response, Tonic; Male; Melatonin; Rats; Rats, Wistar; Serotonin; Serotonin Agents; Swimming; Time Factors; Tryptamines | 2006 |
Beneficial effects of melatonin in protecting against cyclosporine A-induced cardiotoxicity are receptor mediated.
Topics: Animals; Cyclosporine; HSP70 Heat-Shock Proteins; Male; Melatonin; Myocardium; Rats; Rats, Wistar; Receptors, Melatonin; Tryptamines | 2006 |
Melatonin potentiates tear secretion induced by diadenosine tetraphosphate in the rabbit.
Topics: Animals; Dinucleoside Phosphates; Drug Synergism; Male; Melatonin; Rabbits; Tears; Tryptamines | 2006 |
Melatonin and lipid uptake by murine fibroblasts: clinical implications.
Topics: Animals; Azo Compounds; Dose-Response Relationship, Drug; Fibroblasts; Lipid Metabolism; Melatonin; Mice; NIH 3T3 Cells; Oleic Acid; Receptors, Melatonin; Tryptamines | 2006 |
Hypothermic effects of hops are antagonized with the competitive melatonin receptor antagonist luzindole in mice.
Topics: Animals; Antioxidants; Body Temperature; Humulus; Hypnotics and Sedatives; Hypothermia; Male; Medicine, Traditional; Melatonin; Mice; Plant Extracts; Receptor, Melatonin, MT1; Receptor, Melatonin, MT2; Rectum; Sleep; Tryptamines | 2007 |
Melatonin attenuates the development of antinociceptive tolerance to delta-, but not to mu-opioid receptor agonist in mice.
Topics: Analgesics, Opioid; Analysis of Variance; Animals; Antioxidants; Behavior, Animal; Dose-Response Relationship, Drug; Drug Administration Schedule; Drug Combinations; Drug Tolerance; Injections, Intraventricular; Male; Melatonin; Mice; Mice, Inbred Strains; Nociceptors; Oligopeptides; Pain Measurement; Pain Threshold; Receptors, Opioid, delta; Tryptamines | 2007 |
Melatonin antagonizes apoptosis via receptor interaction in U937 monocytic cells.
Topics: Apoptosis; Calcium; Cytoprotection; Humans; Melatonin; Monocytes; Pertussis Toxin; Receptors, Melatonin; Tryptamines; Type C Phospholipases; U937 Cells | 2007 |
[The effect of melatonin on the regulation of collagen accumulation and matrix metalloproteinase-9 and tissue inhibitor of matrix metalloproteinase-1 mRNA and protein in a murine model of chronic asthma].
Topics: Animals; Asthma; Collagen; Dexamethasone; Disease Models, Animal; Male; Matrix Metalloproteinase 9; Melatonin; Mice; Mice, Inbred BALB C; RNA, Messenger; Tissue Inhibitor of Metalloproteinase-1; Tryptamines | 2007 |
Design and synthesis of new N1 and C3-substituted 4-fluoroindolic melatoninergics.
Topics: Animals; Chromatography; Drug Design; Humans; Indenes; Indoles; Iodine Radioisotopes; Mass Spectrometry; Melanophores; Melatonin; Mice; Molecular Structure; NIH 3T3 Cells; Protein Binding; Radioligand Assay; Receptor, Melatonin, MT1; Receptor, Melatonin, MT2; Transition Temperature; Tryptamines; Xenopus laevis | 2007 |
7Alpha-hydroxypregnenolone mediates melatonin action underlying diurnal locomotor rhythms.
Topics: 17-alpha-Hydroxypregnenolone; Animals; Behavior, Animal; Brain; Brain Chemistry; Chlorocebus aethiops; Chromatography, High Pressure Liquid; Circadian Rhythm; Cloning, Molecular; COS Cells; Eye Enucleation; Female; Male; Melatonin; Motor Activity; Pineal Gland; Quail; Transfection; Tryptamines | 2008 |
MT1 melatonin receptor internalization underlies melatonin-induced morphologic changes in Chinese hamster ovary cells and these processes are dependent on Gi proteins, MEK 1/2 and microtubule modulation.
Topics: Animals; Cadaverine; Cell Differentiation; CHO Cells; Clathrin; Cricetinae; Cricetulus; Demecolcine; Extracellular Signal-Regulated MAP Kinases; Guanosine 5'-O-(3-Thiotriphosphate); Humans; Lumicolchicines; MAP Kinase Kinase 1; MAP Kinase Kinase Kinase 2; Melatonin; Microtubules; Pertussis Toxin; Receptor, Melatonin, MT1; Tryptamines | 2008 |
Melatonin antagonizes the intrinsic pathway of apoptosis via mitochondrial targeting of Bcl-2.
Topics: Apoptosis; bcl-2-Associated X Protein; Cytochromes c; Humans; Melatonin; Microscopy, Fluorescence; Mitochondria; Proto-Oncogene Proteins c-bcl-2; Puromycin; Receptor, Melatonin, MT1; Receptor, Melatonin, MT2; RNA, Small Interfering; Tryptamines; U937 Cells | 2008 |
Involvement of the cGMP pathway in mediating the insulin-inhibitory effect of melatonin in pancreatic beta-cells.
Topics: 1-Methyl-3-isobutylxanthine; Animals; Brain; Cell Line, Tumor; Colforsin; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 2; Cyclic Nucleotide-Gated Cation Channels; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Glucose; Guanylate Cyclase; Insulin; Insulin Secretion; Insulin-Secreting Cells; Insulinoma; Melatonin; Pineal Gland; Rats; Rats, Wistar; Receptor, Melatonin, MT2; Signal Transduction; Tetrahydronaphthalenes; Tryptamines | 2008 |
Influence of serotonin on the action of melatonin in MIH-induced meiotic resumption in the oocytes of carp Catla catla.
Topics: Animals; Carps; CDC2 Protein Kinase; Cell Extracts; Cyclin B; Electrophoresis, Polyacrylamide Gel; Female; Immunoblotting; Maturation-Promoting Factor; Meiosis; Melatonin; Metoclopramide; Molecular Weight; Oocytes; Ovary; Receptors, Melatonin; Serotonin; Serotonin Antagonists; Tryptamines | 2008 |
Agomelatine, a melatonin receptor agonist with 5-HT(2C) receptor antagonist properties, protects the developing murine white matter against excitotoxicity.
Topics: Acetamides; Animals; Brain; Brain Diseases; Excitatory Amino Acid Agonists; Ibotenic Acid; Melatonin; Mice; Neuroprotective Agents; Receptor, Serotonin, 5-HT2C; Receptors, Melatonin; Serotonin Antagonists; Tryptamines | 2008 |
Antagonistic effect of luzindole in mice treated with melatonin during the infection with the venezuelan equine encephalomyelitis virus.
Topics: Animals; Encephalitis Virus, Venezuelan Equine; Encephalomyelitis, Venezuelan Equine; Enzyme-Linked Immunosorbent Assay; Male; Melatonin; Mice; Tryptamines | 2009 |
Melatonin-evoked in vivo secretion of protein and amylase from the parotid gland of the anaesthetised rat.
Topics: Amylases; Analysis of Variance; Anesthesia; Animals; Autonomic Denervation; Blotting, Western; Female; Melatonin; Methacholine Chloride; Nitric Oxide Synthase; Parotid Gland; Pentobarbital; Proglumide; Rats; Rats, Sprague-Dawley; Receptors, Melatonin; Saliva; Salivary Proteins and Peptides; Tryptamines | 2008 |
Melatonin as a negative mitogenic hormonal regulator of human prostate epithelial cell growth: potential mechanisms and clinical significance.
Topics: Analysis of Variance; Cell Line, Transformed; Cell Line, Tumor; Cell Proliferation; Cells, Cultured; Cyclin-Dependent Kinase Inhibitor p27; Epithelial Cells; Gene Expression Regulation; Growth Substances; Humans; Immunoblotting; Immunohistochemistry; Male; Melatonin; Prostate; Prostatic Neoplasms; Protein Kinases; Receptors, Androgen; Receptors, Melatonin; Reverse Transcriptase Polymerase Chain Reaction; RNA, Small Interfering; Signal Transduction; Tetrahydronaphthalenes; Tryptamines | 2008 |
Melatonin receptor-mediated protection against myocardial ischaemia/reperfusion injury: role of its anti-adrenergic actions.
Topics: Adrenergic Antagonists; Animals; Colforsin; Cyclic AMP; Guanylate Cyclase; Heart; Indoles; Isoproterenol; Male; Maleimides; Melatonin; Myocardial Infarction; Myocardial Reperfusion Injury; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxadiazoles; p38 Mitogen-Activated Protein Kinases; Propranolol; Protein Kinase C; Quinoxalines; Rats; Rats, Wistar; Receptors, Melatonin; Tryptamines | 2008 |
Melatonin reverses the expression of morphine-induced conditioned place preference through its receptors within central nervous system in mice.
Topics: Animals; Central Nervous System; Conditioning, Operant; Dose-Response Relationship, Drug; Indoles; Injections, Intraperitoneal; Injections, Intraventricular; Male; Melatonin; Mice; Morphine; Morphine Dependence; Narcotic Antagonists; Narcotics; Receptor, Melatonin, MT1; Receptor, Melatonin, MT2; Tryptamines | 2008 |
Melatonin-enhanced hyperactivation of hamster sperm.
Topics: Animals; Calcium; Cells, Cultured; Cricetinae; Culture Media; Dose-Response Relationship, Drug; Male; Melatonin; Mesocricetus; Receptor, Melatonin, MT1; Receptor, Melatonin, MT2; Serum Albumin; Sperm Motility; Spermatozoa; Stimulation, Chemical; Tetrahydronaphthalenes; Time; Tryptamines | 2008 |
Diurnal variation in phagocytic activity of splenic phagocytes in freshwater teleost Channa punctatus: melatonin and its signaling mechanism.
Topics: Adenine; Adenylyl Cyclase Inhibitors; Adenylyl Cyclases; Animals; Cell Survival; Central Nervous System Depressants; Circadian Rhythm; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Enzyme Inhibitors; Estrenes; Fenclonine; Isoquinolines; Melatonin; Perciformes; Phagocytes; Phagocytosis; Pyrrolidinones; Receptors, Melatonin; Signal Transduction; Spleen; Sulfonamides; Tryptamines; Tryptophan Hydroxylase | 2008 |
Melatonin protects against experimental reflux esophagitis.
Topics: Animals; Antioxidants; Cytokines; Drug Antagonism; Esophagitis, Peptic; Hemorrhage; Humans; Inflammation; Inflammation Mediators; Melatonin; Mucous Membrane; Rats; Rats, Sprague-Dawley; Reactive Oxygen Species; Receptor, Melatonin, MT2; Th1 Cells; Tryptamines; Up-Regulation | 2009 |
A novel interplay between membrane and nuclear melatonin receptors in human lymphocytes: significance in IL-2 production.
Topics: Adult; Animals; Cell Membrane; Cell Nucleus; Cyclic AMP; Dinoprostone; Humans; Interleukin-2; Jurkat Cells; Lymphocytes; Melatonin; Middle Aged; Nuclear Receptor Subfamily 1, Group F, Member 1; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Trans-Activators; Tryptamines | 2009 |
Melatonin modulates cell survival of new neurons in the hippocampus of adult mice.
Topics: Adult Stem Cells; Animals; Cell Differentiation; Cell Proliferation; Cell Survival; Cells, Cultured; Depression; Female; Hippocampus; Melatonin; Mice; Mice, Inbred C57BL; Neurogenesis; Neuroglia; Neurons; Neuropsychological Tests; Receptors, Melatonin; Swimming; Tryptamines | 2009 |
An unexpected effect of 5-MCA-NAT in chick retinal development.
Topics: Aging; Animals; Binding Sites; Chick Embryo; Chickens; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Melatonin; Neurogenesis; Neurons; Organ Culture Techniques; Organogenesis; Quinone Reductases; Receptors, G-Protein-Coupled; Receptors, Melatonin; Retina; Second Messenger Systems; Tryptamines; Up-Regulation | 2009 |
Neuroprotection by melatonin on astrocytoma cell death.
Topics: Antioxidants; Apoptosis; Astrocytoma; Benzoquinones; Biological Transport; Calcium; Calcium Channel Blockers; Cell Line, Tumor; Dose-Response Relationship, Drug; Humans; Lipoxygenase Inhibitors; Melatonin; Neomycin; Neuroprotective Agents; Nifedipine; Protein Synthesis Inhibitors; Receptors, Melatonin; Tryptamines; Type C Phospholipases | 2009 |
Luzindole but not 4-phenyl-2- propionamidotetralin (4P-PDOT) diminishes the inhibitory effect of melatonin on murine Colon 38 cancer growth in vitro.
Topics: Animals; Cell Line, Tumor; Colonic Neoplasms; Humans; Melatonin; Mice; Receptors, Melatonin; Tetrahydronaphthalenes; Tryptamines | 2009 |
The inhibition of apoptosis by melatonin in VSC4.1 motoneurons exposed to oxidative stress, glutamate excitotoxicity, or TNF-alpha toxicity involves membrane melatonin receptors.
Topics: Animals; Apoptosis; BH3 Interacting Domain Death Agonist Protein; Calcium; Caspase 8; Cells, Cultured; Glutamic Acid; Hydrogen Peroxide; Melatonin; Membrane Potential, Mitochondrial; Mice; Motor Neurons; Oxidative Stress; Receptor, Melatonin, MT1; Receptor, Melatonin, MT2; Receptors, Melatonin; Tryptamines; Tumor Necrosis Factor-alpha | 2010 |
Melatonin and the time window for the expression of the alpha8 nicotinic acetylcholine receptor in the membrane of chick retinal cells in culture.
Topics: Animals; Cell Differentiation; Cells, Cultured; Chick Embryo; Gene Expression Regulation, Developmental; Iodine Radioisotopes; Melatonin; Protein Isoforms; Receptors, Melatonin; Receptors, Nicotinic; Retina; Time Factors; Tryptamines | 2010 |
Antinociceptive effects of melatonin in a rat model of post-inflammatory visceral hyperalgesia: a centrally mediated process.
Topics: Analgesics; Animals; Colitis; Disease Models, Animal; Hyperalgesia; Inflammation; Male; Melatonin; Narcotic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Melatonin; Tryptamines; Visceral Afferents | 2010 |
Abnormal proliferation and differentiation of osteoblasts from girls with adolescent idiopathic scoliosis to melatonin.
Topics: Adolescent; Adult; Alkaline Phosphatase; Analysis of Variance; Cell Differentiation; Cell Proliferation; Cell Survival; Cells, Cultured; Dose-Response Relationship, Drug; Female; Humans; Male; Melatonin; Osteoblasts; Photomicrography; Receptor, Melatonin, MT2; Scoliosis; Tetrahydronaphthalenes; Tryptamines | 2010 |
Synergistic neuroprotective effect of combined low concentrations of galantamine and melatonin against oxidative stress in SH-SY5Y neuroblastoma cells.
Topics: Analysis of Variance; Cell Death; Cell Line, Tumor; Drug Synergism; Galantamine; Histocytochemistry; Humans; Mecamylamine; Melatonin; Neuroblastoma; Neuroprotective Agents; Oxidative Stress; Signal Transduction; Tryptamines | 2010 |
Melatonin induces pro-apoptotic signaling pathway in human pancreatic carcinoma cells (PANC-1).
Topics: Antioxidants; Apoptosis; bcl-2-Associated X Protein; Blotting, Western; Caspase 3; Caspase 9; Cell Line, Tumor; HSP27 Heat-Shock Proteins; HSP90 Heat-Shock Proteins; Humans; Melatonin; Pancreatic Neoplasms; Receptors, Melatonin; Signal Transduction; Tryptamines | 2010 |
Melatonin increases proliferation of cultured neural stem cells obtained from adult mouse subventricular zone.
Topics: Analysis of Variance; Animals; Antioxidants; Blotting, Western; Cell Proliferation; Cells, Cultured; Immunohistochemistry; Lateral Ventricles; Melatonin; Mice; Neural Stem Cells; Receptors, Melatonin; Tryptamines | 2010 |
Signal transduction of receptor-mediated antiproliferative action of melatonin on human prostate epithelial cells involves dual activation of Gα(s) and Gα(q) proteins.
Topics: Antioxidants; Cell Line, Tumor; Cell Proliferation; Cyclin-Dependent Kinase Inhibitor p27; GTP-Binding Protein alpha Subunit, Gi2; GTP-Binding Protein alpha Subunits, Gq-G11; GTP-Binding Protein alpha Subunits, Gs; Human papillomavirus 18; Humans; Melatonin; Radioimmunoassay; Receptors, Melatonin; Reverse Transcriptase Polymerase Chain Reaction; RNA Interference; Signal Transduction; Tetrahydronaphthalenes; Tryptamines | 2010 |
Melatonin inhibits adipogenesis and enhances osteogenesis of human mesenchymal stem cells by suppressing PPARγ expression and enhancing Runx2 expression.
Topics: Adipogenesis; Alkaline Phosphatase; Analysis of Variance; Biomarkers; Bone Marrow Cells; Cell Proliferation; Cells, Cultured; Core Binding Factor Alpha 1 Subunit; Histocytochemistry; Humans; Melatonin; Mesenchymal Stem Cells; Osteogenesis; PPAR gamma; Tryptamines | 2010 |
Electrophysiological effects of melatonin on mouse Per1 and non-Per1 suprachiasmatic nuclei neurones in vitro.
Topics: Animals; Cell Membrane; Electrophysiological Phenomena; Female; GABA Antagonists; gamma-Aminobutyric Acid; Green Fluorescent Proteins; Hypothalamus; In Vitro Techniques; Male; Melatonin; Mice; Neurons; Patch-Clamp Techniques; Period Circadian Proteins; Pyridazines; Receptor, Melatonin, MT1; Receptor, Melatonin, MT2; Receptors, GABA-A; Suprachiasmatic Nucleus; Synaptic Transmission; Tetrodotoxin; Tryptamines | 2010 |
Anti-inflammatory action of cholecystokinin and melatonin in the rat parotid gland.
Topics: Animals; Anti-Inflammatory Agents; Escherichia coli; Hormone Antagonists; Injections, Intraperitoneal; Lipopolysaccharides; Lysine; Melatonin; Neutrophil Infiltration; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type II; Organ Size; Parasympathectomy; Parotid Gland; Parotitis; Peroxidase; Proglumide; Rats; Rats, Sprague-Dawley; Receptor, Cholecystokinin A; Receptor, Melatonin, MT2; Sincalide; Sympathectomy; Tryptamines | 2010 |
Melatonin modifies the rhythm of protein synthesis.
Topics: Animals; Cells, Cultured; Hepatocytes; Melatonin; Periodicity; Protein Biosynthesis; Rats; Receptors, Melatonin; Tryptamines | 2010 |
Inhibition of breast cancer cell invasion by melatonin is mediated through regulation of the p38 mitogen-activated protein kinase signaling pathway.
Topics: Blotting, Western; Breast Neoplasms; Cell Line, Tumor; Chemokine CXCL12; Female; Gene Expression; Humans; MAP Kinase Signaling System; Matrix Metalloproteinases; Melatonin; Neoplasm Invasiveness; p38 Mitogen-Activated Protein Kinases; Phosphorylation; Receptor, Melatonin, MT1; Reverse Transcriptase Polymerase Chain Reaction; Tryptamines | 2010 |
Design of novel melatonin analogs for the reduction of intraocular pressure in normotensive rabbits.
Topics: Animals; Dose-Response Relationship, Drug; Drug Design; Eye; Glaucoma; Intraocular Pressure; Isoindoles; Melatonin; Ocular Hypertension; Rabbits; Receptor, Melatonin, MT2; Receptors, Melatonin; Structure-Activity Relationship; Time Factors; Tryptamines | 2011 |
Expression of functional melatonin MT(1) receptors in equine luteal cells: in vitro effects of melatonin on progesterone secretion.
Topics: Animals; Blotting, Western; Cholesterol Side-Chain Cleavage Enzyme; Chorionic Gonadotropin; Colforsin; Female; Horses; Luteal Cells; Melatonin; Ovarian Follicle; Progesterone; Receptor, Melatonin, MT1; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Statistics, Nonparametric; Tryptamines | 2011 |
Melatonin-induced protein synthesis in the rat parotid gland.
Topics: Amylases; Animals; Enzyme Inhibitors; Female; Melatonin; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type I; Parotid Gland; Protein Biosynthesis; Rats; Rats, Sprague-Dawley; Receptors, Melatonin; Salivary Glands; Tryptamines; Xerostomia | 2011 |
Rat pial microvascular responses to melatonin during bilateral common carotid artery occlusion and reperfusion.
Topics: Analysis of Variance; Animals; Capillary Permeability; Carotid Artery, Common; Carotid Stenosis; Cerebral Veins; Male; Melatonin; Microvessels; Pia Mater; Prazosin; Rats; Rats, Wistar; Reactive Oxygen Species; Receptors, Melatonin; Reperfusion; Statistics, Nonparametric; Tryptamines | 2011 |
Melatonin elevates intracellular free calcium in human platelets by inositol 1,4,5-trisphosphate independent mechanism.
Topics: Blood Platelets; Calcium; Enzyme Inhibitors; Humans; Inositol 1,4,5-Trisphosphate; Inositol 1,4,5-Trisphosphate Receptors; Macrolides; Melatonin; Mitochondria; Platelet Aggregation; Receptors, Melatonin; Sarcoplasmic Reticulum Calcium-Transporting ATPases; Thrombin; Tryptamines; Type C Phospholipases | 2011 |
Melatonin promotes differentiation of 3T3-L1 fibroblasts.
Topics: 3T3-L1 Cells; Adipocytes; Analysis of Variance; Animals; Aromatase; CCAAT-Enhancer-Binding Protein-alpha; Cell Differentiation; Fibroblasts; Melatonin; Mice; PPAR gamma; Tryptamines | 2012 |
Short-term effects of melatonin and pinealectomy on serotonergic neuronal activity across the light-dark cycle.
Topics: Adrenergic alpha-2 Receptor Antagonists; Animals; Idazoxan; Male; Melatonin; Mood Disorders; Neurons; Photoperiod; Pineal Gland; Piperazines; Pyridines; Raphe Nuclei; Rats; Rats, Sprague-Dawley; Receptor, Melatonin, MT1; Receptor, Melatonin, MT2; Serotonin; Serotonin 5-HT1 Receptor Antagonists; Synaptic Transmission; Tetrahydronaphthalenes; Tryptamines | 2012 |
The interaction of melatonin and agmatine on pentylenetetrazole-induced seizure threshold in mice.
Topics: Agmatine; Analysis of Variance; Animals; Anticonvulsants; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Male; Melatonin; Mice; Pentylenetetrazole; Prazosin; Receptors, Melatonin; Seizures; Time Factors; Tryptamines | 2011 |
The effects of light regimes and hormones on corneal growth in vivo and in organ culture.
Topics: Animals; Central Nervous System Depressants; Chickens; Cornea; Corneal Stroma; Endothelium, Corneal; Light; Melatonin; Ophthalmic Solutions; Organ Culture Techniques; Tretinoin; Tryptamines; Water | 2011 |
Melatonin membrane receptor type MT1 modulates cell-mediated immunity in the seasonally breeding tropical rodent Funambulus pennanti.
Topics: Analysis of Variance; Animals; Breeding; Cell Proliferation; Cells, Cultured; Concanavalin A; Dose-Response Relationship, Drug; Gene Expression Regulation; Immunity; In Vitro Techniques; Interleukin-2; Lymphocytes; Male; Melatonin; Mitogens; Random Allocation; Receptor, Melatonin, MT1; Sciuridae; Seasons; Spleen; Tetrahydronaphthalenes; Tryptamines | 2012 |
Melatonin inhibits glucocorticoid-dependent GR-TIF2 interaction in newborn hamster kidney (BHK) cells.
Topics: Active Transport, Cell Nucleus; Animals; Cell Line; Cricetinae; Cyclic AMP; Dexamethasone; Dimerization; Gene Expression; Glucocorticoids; Immunoprecipitation; Mammary Tumor Virus, Mouse; Melatonin; Microscopy, Fluorescence; Nuclear Receptor Coactivator 2; Receptors, Glucocorticoid; Receptors, Melatonin; Signal Transduction; Tryptamines | 2012 |
Melatonin elicits protein kinase C-mediated calcium response in immortalized GT1-7 GnRH neurons.
Topics: Analysis of Variance; Animals; Benzophenanthridines; Calcium; Cell Line, Transformed; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Gonadotropin-Releasing Hormone; Melatonin; Neurons; Protein Kinase C; Rats; Tryptamines | 2012 |
Melatonin: neuritogenesis and neuroprotective effects in crustacean x-organ cells.
Topics: Animals; Arthropod Proteins; Brachyura; Cells, Cultured; Dose-Response Relationship, Drug; Hydrogen Peroxide; Melatonin; Neurites; Neuroprotective Agents; Neurosecretory Systems; Oxidative Stress; Receptors, Melatonin; Time Factors; Tryptamines | 2012 |
Analyzing the responses of saccharin in context with melatonin receptors on the melanophores of the fish Labeo rohita (Ham.).
Topics: Adrenergic alpha-1 Receptor Antagonists; Animals; Denervation; Fishes; Indoles; Melanophores; Melatonin; Prazosin; Receptors, Melatonin; Saccharin; Signal Transduction; Sweetening Agents; Tryptamines | 2012 |
Melatonin suppresses doxorubicin-induced premature senescence of A549 lung cancer cells by ameliorating mitochondrial dysfunction.
Topics: Antibiotics, Antineoplastic; CDC2 Protein Kinase; Cell Line, Tumor; Cellular Senescence; Cyclin B; Cyclin-Dependent Kinases; Dose-Response Relationship, Drug; Doxorubicin; G2 Phase Cell Cycle Checkpoints; Humans; Lung Neoplasms; Melatonin; Membrane Potential, Mitochondrial; Mitochondria; Oxidative Stress; Reactive Oxygen Species; Receptors, Melatonin; Time Factors; Tryptamines | 2012 |
Phosphorylation of cyclic AMP-response element-binding protein (CREB) is influenced by melatonin treatment in pancreatic rat insulinoma β-cells (INS-1).
Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cell Line, Tumor; Colforsin; Cyclic AMP Response Element-Binding Protein; Dose-Response Relationship, Drug; Fluorescent Antibody Technique; Humans; Insulin-Secreting Cells; Insulinoma; Melatonin; Microscopy, Confocal; Pancreatic Neoplasms; Phosphorylation; Rats; Receptor, Melatonin, MT1; Receptor, Melatonin, MT2; Signal Transduction; Tetrahydronaphthalenes; Time Factors; Transfection; Tryptamines | 2012 |
Melatonin modulates the GABAergic response in cultured rat hippocampal neurons.
Topics: Animals; gamma-Aminobutyric Acid; Hippocampus; Inhibitory Postsynaptic Potentials; Melatonin; Neurons; Neuroprotective Agents; Pyramidal Cells; Rats; Rats, Wistar; Receptors, Melatonin; Tryptamines | 2012 |
Effects of melatonin and its receptor antagonist on retinal pigment epithelial cells against hydrogen peroxide damage.
Topics: Antioxidants; Apoptosis; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Epithelial Cells; Humans; Hydrogen Peroxide; Male; Melatonin; Middle Aged; Oxidative Stress; Primary Cell Culture; Receptors, Melatonin; Retinal Pigment Epithelium; Tetrazolium Salts; Thiazoles; Tryptamines | 2012 |
Anxiolytic effects of the melatonin MT(2) receptor partial agonist UCM765: comparison with melatonin and diazepam.
Topics: Acetamides; Aniline Compounds; Animals; Anti-Anxiety Agents; Anxiety; Diazepam; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Interactions; Drug Partial Agonism; Feeding Behavior; Male; Maze Learning; Melatonin; Motor Activity; Rats; Rats, Sprague-Dawley; Receptor, Melatonin, MT2; Tetrahydronaphthalenes; Tryptamines | 2012 |
Melatonin down-regulates volume-sensitive chloride channels in fibroblasts.
Topics: Animals; Cell Movement; Cell Proliferation; Cell Size; Chloride Channels; Fibroblasts; Indoles; Maleimides; Melatonin; Patch-Clamp Techniques; Protein Kinase C; Rats; Receptor, Melatonin, MT2; Tryptamines | 2012 |
Melatonin decreases duodenal epithelial paracellular permeability via a nicotinic receptor-dependent pathway in rats in vivo.
Topics: Analysis of Variance; Animals; Bicarbonates; Cell Membrane Permeability; Duodenum; Gastrointestinal Motility; Intestinal Mucosa; Intestinal Secretions; Male; Mecamylamine; Melatonin; Perfusion; Rats; Rats, Sprague-Dawley; Receptors, Melatonin; Tryptamines | 2013 |
Physiological crosstalk between melatonin and glucocorticoid receptor modulates T-cell mediated immune responses in a wild tropical rodent, Funambulus pennanti.
Topics: Animals; Cell Proliferation; Corticosterone; Dexamethasone; Gene Expression Regulation; Glucocorticoids; Immunity, Humoral; Interleukin-2; Lymphocyte Activation; Male; Melatonin; Receptors, Glucocorticoid; Receptors, Melatonin; Sciuridae; Seasons; Spleen; T-Lymphocytes; Tryptamines | 2013 |
Seasonal changes and regulation of the glucocorticoid receptor in the testis of the toad Rhinella arenarum.
Topics: Anilides; Animals; Binding Sites; Blotting, Western; Bufo marinus; Cyanoketone; Dexamethasone; Gene Expression Regulation; Glucocorticoids; In Vitro Techniques; Kinetics; Male; Melatonin; Mifepristone; Nitriles; Random Allocation; Receptors, Glucocorticoid; Seasons; Testis; Testosterone; Tosyl Compounds; Tryptamines | 2013 |
Role of melatonin and luzindole in rat mammary cancer.
Topics: Animals; Apoptosis; Biomarkers, Tumor; Disease Models, Animal; DNA Fragmentation; Estradiol; Female; Heme Oxygenase-1; Mammary Neoplasms, Animal; Mammary Neoplasms, Experimental; Melatonin; Methylnitrosourea; Oxidative Stress; Progesterone; Prolactin; Rats; Rats, Sprague-Dawley; Tryptamines | 2012 |
Evidence for feedback control of pineal melatonin secretion.
Topics: Animals; Darkness; Feedback, Physiological; Female; Melatonin; Peromyscus; Pineal Gland; Receptor, Melatonin, MT1; Receptor, Melatonin, MT2; Tetrahydronaphthalenes; Tryptamines | 2013 |
Role of melatonin receptor MT(2) and quinone reductase II in the regulation of the redox status of 3T3-L1 preadipocytes in vitro.
Topics: 3T3-L1 Cells; Adipocytes; Animals; Catalase; Glutathione Peroxidase; Glutathione Reductase; Malondialdehyde; Melatonin; Mice; Oxidation-Reduction; Oxidative Stress; Prazosin; Quinone Reductases; Receptor, Melatonin, MT2; Superoxide Dismutase; Tryptamines | 2013 |
Melatonin inhibits alcohol-induced increases in duodenal mucosal permeability in rats in vivo.
Topics: Animals; Duodenum; Ethanol; Hexamethonium; Intestinal Mucosa; Male; Mecamylamine; Melatonin; Nicotinic Antagonists; Permeability; Rats; Rats, Sprague-Dawley; Receptors, Melatonin; Tryptamines; Wine | 2013 |
Uterine infusion of melatonin or melatonin receptor antagonist alters ovine feto-placental hemodynamics during midgestation.
Topics: Animals; Female; Fetus; Hemodynamics; Melatonin; Placenta; Pregnancy; Receptors, Melatonin; Regional Blood Flow; Sheep; Tryptamines; Umbilical Arteries; Uterus | 2013 |
Melatonin-induced augmentation of collagen deposition in cultures of fibroblasts and myofibroblasts is blocked by luzindole--a melatonin membrane receptors inhibitor.
Topics: Animals; Cells, Cultured; Cicatrix; Collagen; Fibroblasts; Heart; Male; Melatonin; Myocardial Infarction; Myofibroblasts; Rats; Rats, Wistar; Receptors, Melatonin; Tryptamines; Wound Healing | 2013 |
Neu-p11 reduces clock/apelin expression in insulin-resistant mouse adipocyte model.
Topics: 3T3-L1 Cells; Adipocytes; Adipokines; Animals; Apelin; CLOCK Proteins; Glucose; Hypoglycemic Agents; Indoles; Insulin; Insulin Resistance; Intercellular Signaling Peptides and Proteins; Melatonin; Mice; Pyrans; Tryptamines | 2013 |
Melatonin receptors mediate improvements of survival in a model of polymicrobial sepsis.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Indenes; Interleukin-10; Interleukin-6; Male; Melatonin; Mice; Mice, Inbred C3H; Mice, Knockout; Rats; Rats, Sprague-Dawley; Receptor, Melatonin, MT1; Receptor, Melatonin, MT2; Receptors, Melatonin; Sepsis; Tryptamines; Tumor Necrosis Factor-alpha | 2014 |
Melatonin prevents pancreatic β-cell loss due to glucotoxicity: the relationship between oxidative stress and endoplasmic reticulum stress.
Topics: Animals; Antioxidants; Cell Line, Tumor; Cell Survival; Endoplasmic Reticulum Stress; Glucose; Insulin; Insulin-Secreting Cells; Male; Melatonin; Oxidative Stress; Pancreas; Rats; Rats, Sprague-Dawley; Tryptamines | 2014 |
Melatonin receptor subtypes Mel1a and Mel1c but not Mel1b are associated with monochromatic light-induced B-lymphocyte proliferation in broilers.
Topics: Animals; B-Lymphocytes; Bucladesine; Bursa of Fabricius; Cell Proliferation; Chickens; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Dibucaine; Light; Melatonin; Prazosin; Receptors, Melatonin; RNA, Messenger; Tryptamines | 2013 |
Melatonin-induced glycosaminoglycans augmentation in myocardium remote to infarction.
Topics: Animals; Cells, Cultured; Collagen; Fibroblasts; Glycosaminoglycans; Heart Ventricles; Male; Melatonin; Myocardial Infarction; Myocardium; Rats; Rats, Wistar; Receptors, Melatonin; Tryptamines | 2013 |
Anxiolytic-like effects of a new 1-N substituted analog of melatonin in pinealectomized rats.
Topics: Analysis of Variance; Animals; Anti-Anxiety Agents; Defense Mechanisms; Dose-Response Relationship, Drug; Exploratory Behavior; Male; Maze Learning; Melatonin; Pineal Gland; Rats; Rats, Wistar; Reaction Time; Statistics, Nonparametric; Tryptamines | 2014 |
Proliferative effects of melatonin on Schwann cells: implication for nerve regeneration following peripheral nerve injury.
Topics: Animals; Cell Line; Cell Proliferation; Extracellular Signal-Regulated MAP Kinases; Male; Melatonin; Nerve Regeneration; Peripheral Nerve Injuries; Rats; Rats, Wistar; Receptor, Melatonin, MT1; Schwann Cells; Signal Transduction; Tryptamines | 2014 |
Melatonin regulates splenocytes proliferation via IP3-dependent intracellular Ca2+ release in seasonally breeding bird, Perdicula asiatica.
Topics: Animals; Breeding; Calcium Signaling; Cell Proliferation; Galliformes; Gene Expression Regulation, Developmental; Inositol 1,4,5-Trisphosphate Receptors; Lymphocytes; Melatonin; Receptor, Melatonin, MT1; Receptors, Melatonin; Spleen; Tryptamines | 2014 |
The effects of exogenous melatonin and melatonin receptor blockade on aggression and estrogen-dependent gene expression in male California mice (Peromyscus californicus).
Topics: Aggression; Animals; Estrogen Receptor alpha; Estrogens; Gene Expression Regulation; Letrozole; Male; Melatonin; Nitriles; Peromyscus; Proto-Oncogene Proteins c-fos; Receptors, Melatonin; Receptors, Oxytocin; Triazoles; Tryptamines | 2014 |
An interplay between 2 signaling pathways: melatonin-cAMP and IP3-Ca2+ signaling pathways control intraerythrocytic development of the malaria parasite Plasmodium falciparum.
Topics: Animals; Calcium Signaling; Cyclic AMP; Erythrocytes; Humans; Imines; Inositol 1,4,5-Trisphosphate; Malaria, Falciparum; Melatonin; Models, Biological; Plasmodium falciparum; Receptors, Melatonin; Signal Transduction; Tryptamines | 2014 |
Labeled [³H]--thymidine incorporation in the DNA of 3T3-L1 preadipocytes due to MT₂- and not MT₃- melatonin receptor.
Topics: 3T3-L1 Cells; Adipocytes; Animals; Cell Proliferation; DNA; Melatonin; Mice; Prazosin; Receptor, Melatonin, MT2; Receptors, Melatonin; Thymidine; Tryptamines | 2014 |
Beneficial effects of melatonin on in vitro bovine embryonic development are mediated by melatonin receptor 1.
Topics: Animals; Blastocyst; Cattle; Embryonic Development; Glutathione Peroxidase; Melatonin; Receptor, Melatonin, MT1; Receptor, Melatonin, MT2; Superoxide Dismutase; Superoxide Dismutase-1; Tetrahydronaphthalenes; Tryptamines | 2014 |
Piromelatine exerts antinociceptive effect via melatonin, opioid, and 5HT1A receptors and hypnotic effect via melatonin receptors in a mouse model of neuropathic pain.
Topics: Analgesics; Animals; Disease Models, Animal; Hyperalgesia; Hypnotics and Sedatives; Indoles; Male; Melatonin; Mice; Naloxone; Narcotic Antagonists; Neuralgia; Pain Measurement; Peripheral Nerve Injuries; Piperazines; Pyrans; Pyridines; Receptor, Serotonin, 5-HT1A; Receptors, Melatonin; Receptors, Opioid; Sciatic Nerve; Serotonin Antagonists; Sleep Wake Disorders; Tryptamines | 2014 |
Effect of melatonin and analogues on corneal wound healing: involvement of Mt2 melatonin receptor.
Topics: Animals; Antioxidants; Blotting, Western; Burns, Chemical; Cell Line; Epithelium, Corneal; Eye Burns; Eye Proteins; Heptanol; Immunohistochemistry; Isoindoles; Male; Melatonin; Rabbits; Receptor, Melatonin, MT2; Reverse Transcriptase Polymerase Chain Reaction; Tears; Tryptamines; Wound Healing | 2015 |
Melatonin receptor-mediated protection against myocardial ischemia/reperfusion injury: role of SIRT1.
Topics: Animals; Apoptosis; Carbazoles; Caspase 3; L-Lactate Dehydrogenase; Male; Melatonin; Myocardial Reperfusion Injury; Myocardium; Oxidative Stress; Rats; Rats, Sprague-Dawley; Receptors, Melatonin; Signal Transduction; Sirtuin 1; Superoxide Dismutase; Tryptamines | 2014 |
[Investigation into the vestibular protective properties of melatoninergic agents].
Topics: Acetamides; Animals; Animals, Newborn; Animals, Outbred Strains; Bicuculline; Central Nervous System Depressants; Excitatory Postsynaptic Potentials; GABA-A Receptor Antagonists; Male; Medulla Oblongata; Melatonin; Neurons; Patch-Clamp Techniques; Rats; Receptor, Melatonin, MT1; Receptor, Melatonin, MT2; Tryptamines; Vestibule, Labyrinth | 2014 |
Evidence for the presence of novel β-melatonin receptors along with classical α-melatonin receptors in the fish Rasbora daniconius (Ham.).
Topics: Animals; Cell Aggregation; Cyprinidae; Denervation; Dose-Response Relationship, Drug; Female; Fish Proteins; Guanethidine; Indoles; Male; Melanophores; Melatonin; Phentolamine; Propranolol; Receptors, Melatonin; Tryptamines; Yohimbine | 2015 |
A new role for 5-methoxytryptophol on bone cells function in vitro.
Topics: Animals; Cell Differentiation; Cell Line; Cell Survival; Dose-Response Relationship, Drug; Gene Expression Regulation; In Vitro Techniques; Indoles; MAP Kinase Signaling System; Melatonin; Mice; Osteoblasts; Osteoclasts; RANK Ligand; Tryptamines | 2015 |
The influence od melatonin receptors antagonists, luzindole and 4-phenyl-2-propionamidotetralin (4-P-PDOT), on melatonin-dependent vasopressin and adrenocorticotropic hormone (ACTH) release from the rat hypothalamo-hypophysial system. In vitro and in vivo
Topics: Adrenocorticotropic Hormone; Animals; Corticosterone; Hypothalamo-Hypophyseal System; Male; Melatonin; Rats, Wistar; Receptor, Melatonin, MT1; Receptor, Melatonin, MT2; Tetrahydronaphthalenes; Tryptamines; Vasopressins | 2014 |
Epigenetic mechanisms of melatonin action in human SH-SY5Y neuroblastoma cells.
Topics: Acetylation; Cell Line, Tumor; Chromatin Assembly and Disassembly; Epigenesis, Genetic; Gene Expression Regulation, Neoplastic; Histones; Humans; Melatonin; Neuroblastoma; p300-CBP Transcription Factors; Protein Processing, Post-Translational; Proto-Oncogene Proteins c-akt; Receptor, Melatonin, MT1; Signal Transduction; Tryptamines | 2015 |
Melatonin stimulates dendrite formation and complexity in the hilar zone of the rat hippocampus: participation of the Ca++/Calmodulin complex.
Topics: Animals; Calcium; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Calmodulin; Dendrites; Hippocampus; Male; Melatonin; Neurogenesis; Phosphorylation; Protein Kinase C; Rats, Wistar; Receptors, Melatonin; Tryptamines | 2015 |
Melatonin attenuates methamphetamine-induced neuroinflammation through the melatonin receptor in the SH-SY5Y cell line.
Topics: Antioxidants; Cell Line, Tumor; Central Nervous System Stimulants; Culture Media, Serum-Free; Gene Expression Regulation, Neoplastic; Humans; I-kappa B Proteins; Inflammation; Melatonin; Methamphetamine; Neuroblastoma; Protein Transport; Receptors, Melatonin; RNA, Small Interfering; Time Factors; Transfection; Tryptamines; Tumor Necrosis Factor-alpha | 2015 |
Role of melatonin, melatonin receptors and STAT3 in the cardioprotective effect of chronic and moderate consumption of red wine.
Topics: Animals; Cardiotonic Agents; Male; Melatonin; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocardial Infarction; Prazosin; Rats; Rats, Wistar; Receptor, Melatonin, MT1; Receptor, Melatonin, MT2; Receptors, Melatonin; Receptors, Tumor Necrosis Factor, Type II; STAT3 Transcription Factor; Tryptamines; Tyrphostins; Wine | 2015 |
Melatonin receptor signaling contributes to neuroprotection upon arousal from torpor in thirteen-lined ground squirrels.
Topics: Adaptation, Physiological; Animals; Brain; Caspase 3; Central Nervous System; Female; Gene Expression Regulation, Enzymologic; Hibernation; Male; Melatonin; Mitochondria; Receptor, Melatonin, MT1; Receptor, Melatonin, MT2; Sciuridae; Seasons; Signal Transduction; Tryptamines | 2015 |
Melatonin Upregulates the Activity of AMPK and Attenuates Lipid Accumulation in Alcohol-induced Rats.
Topics: Alanine Transaminase; AMP-Activated Protein Kinases; Animals; Antioxidants; Aspartate Aminotransferases; Disease Models, Animal; Fatty Liver, Alcoholic; Hep G2 Cells; Humans; Lipid Metabolism; Lipid Peroxidation; Liver; Malondialdehyde; Melatonin; Rats; Receptor, Melatonin, MT1; Superoxide Dismutase; Triglycerides; Tryptamines; Up-Regulation | 2016 |
Kynuramines induce overexpression of heat shock proteins in pancreatic cancer cells via 5-hydroxytryptamine and MT1/MT2 receptors.
Topics: Cell Line, Tumor; Heat-Shock Proteins; Humans; Ketanserin; Kynuramine; Melatonin; Pancreatic Neoplasms; Receptor, Melatonin, MT1; Receptor, Melatonin, MT2; Serotonin; Tropanes; Tryptamines; Tryptophan | 2015 |
A Dual Role for Melatonin in Medaka Ovulation: Ensuring Prostaglandin Synthesis and Actin Cytoskeleton Rearrangement in Follicular Cells.
Topics: Actins; Animals; Cytoskeleton; Female; Gene Expression Regulation; Melatonin; Oryzias; Ovarian Follicle; Ovulation; Prostaglandins; Receptors, Melatonin; Tryptamines | 2016 |
Effect of Melatonin and 5-Methoxycarbonylamino-N-Acetyltryptamine on the Intraocular Pressure of Normal and Glaucomatous Mice.
Topics: Animals; Dose-Response Relationship, Drug; Glaucoma; Intraocular Pressure; Melatonin; Mice; Mice, Inbred C57BL; Mice, Inbred DBA; Receptor, Melatonin, MT2; Tetrahydronaphthalenes; Tryptamines | 2016 |
Role of Neu-p11/luzindole in the regulation of insulin signaling pathways and insulin resistance.
Topics: 3T3-L1 Cells; Adipocytes; Animals; Glycogen Synthase Kinase 3 beta; Indoles; Insulin; Insulin Receptor Substrate Proteins; Insulin Resistance; Melatonin; Mice; Phosphatidylinositol 3-Kinases; Pyrans; Signal Transduction; Tryptamines | 2016 |
Effects and mechanisms of melatonin on neural differentiation of induced pluripotent stem cells.
Topics: Animals; Cell Differentiation; Cell Survival; Cells, Cultured; Cellular Reprogramming Techniques; Chromones; Induced Pluripotent Stem Cells; Melatonin; Mice; Morpholines; Neural Stem Cells; Neurogenesis; Neurons; Receptors, Melatonin; Tryptamines | 2016 |
Effect of melatonin on monochromatic light-induced T-lymphocyte proliferation in the thymus of chickens.
Topics: Animals; Cell Proliferation; Cells, Cultured; Chickens; Concanavalin A; Gene Expression; Immunohistochemistry; Light; Male; Melatonin; Prazosin; Proliferating Cell Nuclear Antigen; Receptors, Melatonin; RNA, Messenger; T-Lymphocytes; Tetrahydronaphthalenes; Thymus Gland; Tryptamines | 2016 |
Melatonin increases the regularity of cardiac rhythmicity in the Drosophila heart in both wild-type and strains bearing pathogenic mutations.
Topics: Animals; Ascorbic Acid; Cardiovascular Physiological Phenomena; Drosophila; Female; Heart; Male; Melatonin; Mutation; Receptors, G-Protein-Coupled; Serotonin; Tryptamines | 2017 |
Melatonin modulates the functions of porcine granulosa cells via its membrane receptor MT2 in vitro.
Topics: Animals; Apoptosis; Cells, Cultured; Female; Gene Expression Regulation; Granulosa Cells; Isoindoles; Melatonin; Receptor, Melatonin, MT2; Swine; Tryptamines | 2016 |
Exogenous melatonin reduced blood pressure in late-term ovine fetus via MT1/MT2 receptor pathways.
Topics: Adrenergic alpha-1 Receptor Antagonists; Adrenocorticotropic Hormone; Aldosterone; Angiotensin I; Angiotensin II; Animals; Atrial Natriuretic Factor; Blood Pressure; Corticotropin-Releasing Hormone; Endothelins; Fetus; Heart Rate; Hydrocortisone; Melatonin; Prazosin; Receptor, Melatonin, MT1; Receptor, Melatonin, MT2; Sheep; Sheep, Domestic; Signal Transduction; Tryptamines | 2016 |
Effect of Melatonin and Calmodulin in an Idiopathic Scoliosis Model.
Topics: Animals; Calmodulin; Disease Models, Animal; Female; Humans; Lighting; Melatonin; Rats; Scoliosis; Tamoxifen; Tryptamines | 2016 |
Activation of melatonin receptor (MT1/2) promotes P-gp transporter in methamphetamine-induced toxicity on primary rat brain microvascular endothelial cells.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 1; Brain; Cells, Cultured; Central Nervous System Stimulants; Endothelial Cells; Melatonin; Methamphetamine; Microvessels; Neuroprotective Agents; Rats; Reactive Nitrogen Species; Reactive Oxygen Species; Receptor, Melatonin, MT1; Receptor, Melatonin, MT2; Rhodamine 123; Tryptamines; Verapamil | 2017 |
The value of applying a melatonin antagonist (Luzindole) in improving the success rate of the bipedal rat scoliosis model.
Topics: Animals; Disease Models, Animal; Melatonin; Random Allocation; Rats, Sprague-Dawley; Scoliosis; Tryptamines | 2017 |
Melatonin antagonizes interleukin-18-mediated inhibition on neural stem cell proliferation and differentiation.
Topics: Animals; Brain-Derived Neurotrophic Factor; Cell Differentiation; Cell Proliferation; Glial Cell Line-Derived Neurotrophic Factor; Interleukin-18; Melatonin; Mice; Neural Stem Cells; Rats, Wistar; Receptor, trkB; Receptors, Melatonin; Tryptamines | 2017 |
Melatonin protects bone marrow mesenchymal stem cells against iron overload-induced aberrant differentiation and senescence.
Topics: Adipogenesis; Animals; Bone Marrow Cells; Cell Differentiation; Cell Proliferation; Cellular Senescence; Ferric Compounds; Iron Overload; Iron-Dextran Complex; Male; MAP Kinase Signaling System; Melatonin; Mesenchymal Stem Cells; Mice, Inbred C57BL; Mitochondria; Osteogenesis; Quaternary Ammonium Compounds; Reactive Oxygen Species; Tryptamines | 2017 |
Melatonin protects against cisplatin-induced ovarian damage in mice via the MT1 receptor and antioxidant activity.
Topics: Animals; Antioxidants; Apoptosis; Biomarkers; Cell Proliferation; Cisplatin; Dose-Response Relationship, Drug; Female; Gene Expression Regulation; Melatonin; Mice; Ovary; Receptor, Melatonin, MT1; Receptor, Melatonin, MT2; Tetrahydronaphthalenes; Tryptamines | 2017 |
Melatonin inhibits nucleus pulposus (NP) cell proliferation and extracellular matrix (ECM) remodeling via the melatonin membrane receptors mediated PI3K-Akt pathway.
Topics: Aggrecans; Cell Proliferation; Collagen Type II; Extracellular Matrix; Humans; Intervertebral Disc Degeneration; Matrix Metalloproteinase 3; Matrix Metalloproteinase 9; Melatonin; Nucleus Pulposus; Phosphatidylinositol 3-Kinases; Primary Cell Culture; Proto-Oncogene Proteins c-akt; Receptor, Melatonin, MT1; Receptor, Melatonin, MT2; Signal Transduction; Tryptamines | 2017 |
Melatonin reduces oxidative damage and upregulates heat shock protein 90 expression in cryopreserved human semen.
Topics: Adenosine Triphosphate; Antioxidants; Benzoquinones; Cell Survival; Cryopreservation; Cryoprotective Agents; Gene Expression Regulation; HSP90 Heat-Shock Proteins; Humans; Lactams, Macrocyclic; Lipid Peroxidation; Male; Melatonin; NF-E2-Related Factor 2; Oxidative Stress; Protein Biosynthesis; Proto-Oncogene Proteins c-bcl-2; Reactive Oxygen Species; Receptor, Melatonin, MT1; Semen; Semen Analysis; Sperm Motility; Tetrahydronaphthalenes; Tryptamines | 2017 |
Melatonin promotes neuroprotection of induced pluripotent stem cells-derived neural stem cells subjected to H
Topics: Animals; Apoptosis; Cell Proliferation; Cells, Cultured; Chromones; Hydrogen Peroxide; Induced Pluripotent Stem Cells; Melatonin; Membrane Potential, Mitochondrial; Mice; Morpholines; Neural Stem Cells; Neuroprotection; Neuroprotective Agents; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Receptors, Melatonin; Signal Transduction; Tryptamines | 2018 |
Therapeutic effect of perinatal exogenous melatonin on behavioral and histopathological changes and antioxidative enzymes in neonate mouse model of cortical malformation.
Topics: Animals; Animals, Newborn; Antioxidants; Carcinogens; Catalase; Disease Models, Animal; Exploratory Behavior; Female; Gene Expression Regulation, Developmental; Glutathione Peroxidase; Intermediate Filaments; Malformations of Cortical Development; Malondialdehyde; Maze Learning; Melatonin; Methylazoxymethanol Acetate; Mice; Mice, Inbred BALB C; Nitroprusside; Pregnancy; Prenatal Exposure Delayed Effects; Superoxide Dismutase; Tryptamines | 2018 |
The Melatonin Analog IQM316 May Induce Adult Hippocampal Neurogenesis and Preserve Recognition Memories in Mice.
Topics: Animals; Cell Differentiation; Cell Proliferation; Hippocampus; Male; Melatonin; Memory; Memory, Long-Term; Mice; Mice, Inbred C57BL; Neural Stem Cells; Neurogenesis; Neurons; Tryptamines | 2018 |
Melatonin reduces two-cell block via nonreceptor pathway in mice.
Topics: Animals; Antioxidants; Female; Glutathione Peroxidase; Matrix Metalloproteinase 14; Matrix Metalloproteinase 15; Melatonin; Mice; Superoxide Dismutase; Tryptamines | 2018 |
Melatonin protects rabbit spermatozoa from cryo-damage via decreasing oxidative stress.
Topics: Acrosome; Animals; Antioxidants; Catalase; Cryopreservation; Cryoprotective Agents; Glutathione; Glutathione Peroxidase; Hydrogen Peroxide; Lipid Peroxidation; Male; Melatonin; Membrane Potential, Mitochondrial; Oxidative Stress; Rabbits; Reactive Oxygen Species; Receptor, Melatonin, MT1; Semen; Semen Analysis; Semen Preservation; Sperm Motility; Spermatozoa; Superoxide Dismutase; Tryptamines | 2019 |
Vertebrates originally possess four functional subtypes of G protein-coupled melatonin receptor.
Topics: Animals; Brain; Down-Regulation; Eye; Melatonin; Oryzias; Phylogeny; Pituitary Gland; Receptors, Melatonin; Synteny; Tetrahydronaphthalenes; Tryptamines; Vertebrates | 2019 |
Melatonin prevents lung injury by regulating apelin 13 to improve mitochondrial dysfunction.
Topics: Animals; Apelin; Apoptosis; Bleomycin; Cell Line, Tumor; Cellular Senescence; Epithelial Cells; Lung; Lung Injury; Male; Melatonin; Mice; Mice, Inbred C57BL; Mitochondria; Pulmonary Fibrosis; Reactive Oxygen Species; Receptors, Melatonin; Respiratory Mucosa; Tryptamines | 2019 |
MicroRNA-92b-5p modulates melatonin-mediated osteogenic differentiation of bone marrow mesenchymal stem cells by targeting ICAM-1.
Topics: Bone Resorption; Cell Differentiation; Cell Line; Humans; Intercellular Adhesion Molecule-1; Melatonin; Mesenchymal Stem Cells; MicroRNAs; Osteoblasts; Osteogenesis; Osteoporosis; Tryptamines | 2019 |
Role of Melatonin Receptors in Hyperthermia-Induced Acute Seizure Model of Rats.
Topics: Animals; Anticonvulsants; Brain; Central Nervous System Depressants; Fever; Male; Melatonin; Prazosin; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptors, Melatonin; Seizures, Febrile; Tryptamines | 2019 |
Evaluation of the anticonvulsant effect of novel melatonin derivatives in the intravenous pentylenetetrazol seizure test in mice.
Topics: Administration, Intravenous; Animals; Anticonvulsants; Drug Interactions; Male; Melatonin; Mice; Molecular Docking Simulation; Pentylenetetrazole; Protein Conformation; Receptor, Melatonin, MT1; Receptor, Melatonin, MT2; Seizures; Tryptamines | 2019 |
Biological effects of melatonin on human adipose‑derived mesenchymal stem cells.
Topics: Adipogenesis; Adult; Cell Differentiation; Cell Proliferation; Female; Gene Expression Regulation, Developmental; Humans; Leukocytes, Mononuclear; Melatonin; Mesenchymal Stem Cells; Middle Aged; Signal Transduction; SOXB1 Transcription Factors; Tryptamines | 2019 |
Melatonin biosynthesis restored by CpG oligodeoxynucleotides attenuates allergic airway inflammation via regulating NLRP3 inflammasome.
Topics: Animals; Asthma; Bronchoalveolar Lavage Fluid; Cytokines; Female; Hypersensitivity; Inflammasomes; Inflammation; Lung; Melatonin; Mice; Mice, Inbred C57BL; NLR Family, Pyrin Domain-Containing 3 Protein; Oligodeoxyribonucleotides; Th2 Cells; Tryptamines | 2019 |
Luzindole attenuates LPS/d-galactosamine-induced acute hepatitis in mice.
Topics: Acute Disease; Animals; Anti-Inflammatory Agents; Apoptosis; Disease Models, Animal; Galactosamine; Hepatitis; Humans; Interleukin-6; Lipopolysaccharides; Liver; Melatonin; Mice; Mice, Inbred BALB C; Receptors, Melatonin; Tryptamines; Tumor Necrosis Factor-alpha | 2020 |
Melatonin decreases cocaine-induced locomotor activity in pinealectomized rats.
Topics: Animals; Central Nervous System Depressants; Circadian Rhythm; Cocaine-Related Disorders; Enzyme-Linked Immunosorbent Assay; Humans; Locomotion; Male; Melatonin; Pinealectomy; Random Allocation; Rats, Wistar; Reproducibility of Results; Time Factors; Treatment Outcome; Tryptamines | 2020 |
Inhibition of autophagy triggers melatonin-induced apoptosis in glioblastoma cells.
Topics: Acetamides; Antineoplastic Agents; Apoptosis; Autophagy; Brain Neoplasms; Cell Line, Tumor; Dose-Response Relationship, Drug; Glioblastoma; Humans; Macrolides; Melatonin; Receptors, Melatonin; Tryptamines | 2019 |
Adult neural stem cell activation in mice is regulated by the day/night cycle and intracellular calcium dynamics.
Topics: Adult Stem Cells; Animals; Astrocytes; Behavior, Animal; Calcium; Cell Division; Cell Proliferation; Circadian Rhythm; Cytosol; Epidermal Growth Factor; Inositol 1,4,5-Trisphosphate Receptors; Intracellular Space; Melatonin; Mice; Neural Stem Cells; Optogenetics; Signal Transduction; Tryptamines | 2021 |
Acute blockade of endogenous melatonin by Luzindole, with or without peripheral LPS injection, induces jejunal inflammation and morphological alterations in Swiss mice.
Topics: Animals; Inflammation; Jejunum; Lipopolysaccharides; Melatonin; Mice; Tryptamines | 2021 |
Effect of melatonin and luzindole antagonist on fipronil toxicity, detoxification and antioxidant enzyme system in different tissues of Helicoverpa armigera (Lepidoptera: Noctuidae).
Topics: Animals; Antioxidants; Larva; Melatonin; Moths; Superoxide Dismutase | 2023 |
Blockade of Melatonin Receptors Abolishes Its Antiarrhythmic Effect and Slows Ventricular Conduction in Rat Hearts.
Topics: Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Connexin 43; Melatonin; Myocytes, Cardiac; Rats; Receptors, Melatonin | 2023 |