Page last updated: 2024-09-03

luzindole and colforsin

luzindole has been researched along with colforsin in 16 studies

Compound Research Comparison

Studies
(luzindole)
Trials
(luzindole)
Recent Studies (post-2010)
(luzindole)
Studies
(colforsin)
Trials
(colforsin)
Recent Studies (post-2010) (colforsin)
265111913,460461,298

Protein Interaction Comparison

ProteinTaxonomyluzindole (IC50)colforsin (IC50)
nuclear receptor subfamily 0 group B member 1Homo sapiens (human)1.729
5-hydroxytryptamine receptor 1AHomo sapiens (human)0.041
Adenylate cyclase type 1Homo sapiens (human)0.0955

Research

Studies (16)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's5 (31.25)18.2507
2000's8 (50.00)29.6817
2010's3 (18.75)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Gan, J; Iuvone, PM1
Dubocovich, ML; Witt-Enderby, PA1
Barrett, P; Canning, SJ; Conway, S; Delagrange, P; Drew, JE; Guardiola-Lemaitre, B; Jockers, R; Morgan, PJ; Strosberg, AD1
Flanders, S; Lew, MJ1
Calvo, JR; García-Pergañeda, A; Guerrero, JM; Paz Romero, M; Pozo, D; Rafii-El-Idrissi, M1
Beckmann, A; Fauteck, JD; Musshoff, U; Peschke, D; Peschke, E; Schmidt, F1
Markowska, M; Mrozkowiak, A; Skwarlo-Sonta, K1
Chankiewitz, E; Csernus, VJ; Mühlbauer, E; Musshoff, U; Peschke, D; Peschke, E1
Markowska, M; Mrozkowiak, A; Pawlak, J; Skwarło-Sońta, K1
Alonso-Vale, MI; Andreotti, S; Anhê, GF; das Neves Borges-Silva, C; Lima, FB; Neto, JC; Peres, SB1
Mühlbauer, E; Peschke, E; Stumpf, I1
Genade, S; Genis, A; Huisamen, B; Lochner, A; Ytrehus, K1
Sampaio, Lde F1
Guerra, M; Pedreros, M; Ratto, M1
Albrecht, E; Bazwinsky-Wutschke, I; Mühlbauer, E; Peschke, E; Wolgast, S1
Hirai, K; Nishiyama, K1

Other Studies

16 other study(ies) available for luzindole and colforsin

ArticleYear
Melatonin receptor-mediated inhibition of cyclic AMP accumulation in chick retinal cell cultures.
    Journal of neurochemistry, 1994, Volume: 63, Issue:1

    Topics: 1-Methyl-3-isobutylxanthine; 5-Methoxytryptamine; Animals; Cells, Cultured; Chick Embryo; Colforsin; Cyclic AMP; Iodine Radioisotopes; Melatonin; Neurons; Pertussis Toxin; Photoreceptor Cells; Potassium; Receptors, Cell Surface; Receptors, Melatonin; Retina; Second Messenger Systems; Structure-Activity Relationship; Tryptamines; Virulence Factors, Bordetella

1994
Characterization and regulation of the human ML1A melatonin receptor stably expressed in Chinese hamster ovary cells.
    Molecular pharmacology, 1996, Volume: 50, Issue:1

    Topics: Animals; Binding, Competitive; CHO Cells; Colforsin; Cricetinae; Cyclic AMP; Humans; Kinetics; Melatonin; Receptors, Cell Surface; Receptors, Melatonin; Recombinant Proteins; Transfection; Tryptamines

1996
Identification of Mel1a melatonin receptors in the human embryonic kidney cell line HEK293: evidence of G protein-coupled melatonin receptors which do not mediate the inhibition of stimulated cyclic AMP levels.
    FEBS letters, 1997, Apr-21, Volume: 407, Issue:1

    Topics: Binding, Competitive; Cell Line; Colforsin; Cyclic AMP; Genomic Library; GTP-Binding Proteins; Humans; Kidney; Melatonin; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; RNA, Messenger; Sequence Analysis, DNA; Serotonin; Signal Transduction; Tryptamines

1997
Mechanisms of melatonin-induced vasoconstriction in the rat tail artery: a paradigm of weak vasoconstriction.
    British journal of pharmacology, 1999, Volume: 126, Issue:6

    Topics: Acetamides; Animals; Anticonvulsants; Arteries; Calcium Channel Blockers; Charybdotoxin; Colforsin; Dose-Response Relationship, Drug; Hypnotics and Sedatives; In Vitro Techniques; Indoles; Male; Melatonin; Nifedipine; Nitroprusside; Potassium Channels; Rats; Rats, Sprague-Dawley; Tail; Tryptamines; Vasoconstriction; Vasoconstrictor Agents; Vasodilator Agents; Vasopressins

1999
Characterization of membrane melatonin receptor in mouse peritoneal macrophages: inhibition of adenylyl cyclase by a pertussis toxin-sensitive G protein.
    Journal of neuroimmunology, 1999, Mar-01, Volume: 95, Issue:1-2

    Topics: Adenosine Diphosphate Ribose; Adenylate Cyclase Toxin; Adenylyl Cyclase Inhibitors; Animals; Blotting, Western; Colforsin; Cyclic AMP; GTP-Binding Protein alpha Subunits, Gi-Go; Iodine Radioisotopes; Kinetics; Macrophages, Peritoneal; Melatonin; Mice; Neuroimmunomodulation; Pertussis Toxin; Radioligand Assay; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Serotonin; Signal Transduction; Tryptamines; Virulence Factors, Bordetella

1999
Evidence for a melatonin receptor within pancreatic islets of neonate rats: functional, autoradiographic, and molecular investigations.
    Journal of pineal research, 2000, Volume: 28, Issue:3

    Topics: Animals; Animals, Newborn; Autoradiography; Colforsin; DNA Primers; Dose-Response Relationship, Drug; Female; Gene Expression; Guanosine 5'-O-(3-Thiotriphosphate); Insulin; Insulin Secretion; Islets of Langerhans; Male; Melatonin; Rats; Rats, Wistar; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Tryptamines

2000
Influence of melatonin on chicken lymphocytes in vitro: involvement of membrane receptors.
    Neuro endocrinology letters, 2002, Volume: 23 Suppl 1

    Topics: Animals; Antioxidants; Cell Division; Cell Membrane; Cells, Cultured; Chickens; Colforsin; Cyclic AMP; Lymphocytes; Male; Melatonin; Phytohemagglutinins; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Signal Transduction; Spleen; Tryptamines

2002
Receptor (MT(1)) mediated influence of melatonin on cAMP concentration and insulin secretion of rat insulinoma cells INS-1.
    Journal of pineal research, 2002, Volume: 33, Issue:2

    Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Biological Transport; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Insulin; Insulin Secretion; Insulinoma; Islets of Langerhans; Melatonin; Pancreatic Neoplasms; Phosphodiesterase Inhibitors; Polymerase Chain Reaction; Probenecid; Rats; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Signal Transduction; Tryptamines; Tumor Cells, Cultured

2002
Intracellular second messengers involved in melatonin signal transduction in chicken splenocytes in vitro.
    Journal of pineal research, 2004, Volume: 37, Issue:3

    Topics: Animals; Cell Proliferation; Cells, Cultured; Chickens; Colforsin; Cyclic AMP; Inositol 1,4,5-Trisphosphate; Male; Melatonin; Receptor, Melatonin, MT2; Receptors, Melatonin; Second Messenger Systems; Signal Transduction; Spleen; Tetrahydronaphthalenes; Tryptamines

2004
Melatonin enhances leptin expression by rat adipocytes in the presence of insulin.
    American journal of physiology. Endocrinology and metabolism, 2005, Volume: 288, Issue:4

    Topics: Adipocytes; Animals; Colforsin; Dexamethasone; Dose-Response Relationship, Drug; Drug Interactions; Gene Expression; Glucocorticoids; Inhibitory Concentration 50; Insulin; Leptin; Male; Melatonin; Pertussis Toxin; Phosphorylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Receptor, Insulin; Receptor, Melatonin, MT1; Reverse Transcriptase Polymerase Chain Reaction; RNA; Tryptamines

2005
Involvement of the cGMP pathway in mediating the insulin-inhibitory effect of melatonin in pancreatic beta-cells.
    Journal of pineal research, 2008, Volume: 45, Issue:3

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Brain; Cell Line, Tumor; Colforsin; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 2; Cyclic Nucleotide-Gated Cation Channels; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Glucose; Guanylate Cyclase; Insulin; Insulin Secretion; Insulin-Secreting Cells; Insulinoma; Melatonin; Pineal Gland; Rats; Rats, Wistar; Receptor, Melatonin, MT2; Signal Transduction; Tetrahydronaphthalenes; Tryptamines

2008
Melatonin receptor-mediated protection against myocardial ischaemia/reperfusion injury: role of its anti-adrenergic actions.
    Journal of pineal research, 2008, Volume: 45, Issue:4

    Topics: Adrenergic Antagonists; Animals; Colforsin; Cyclic AMP; Guanylate Cyclase; Heart; Indoles; Isoproterenol; Male; Maleimides; Melatonin; Myocardial Infarction; Myocardial Reperfusion Injury; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxadiazoles; p38 Mitogen-Activated Protein Kinases; Propranolol; Protein Kinase C; Quinoxalines; Rats; Rats, Wistar; Receptors, Melatonin; Tryptamines

2008
An unexpected effect of 5-MCA-NAT in chick retinal development.
    International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience, 2009, Volume: 27, Issue:6

    Topics: Aging; Animals; Binding Sites; Chick Embryo; Chickens; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Melatonin; Neurogenesis; Neurons; Organ Culture Techniques; Organogenesis; Quinone Reductases; Receptors, G-Protein-Coupled; Receptors, Melatonin; Retina; Second Messenger Systems; Tryptamines; Up-Regulation

2009
Expression of functional melatonin MT(1) receptors in equine luteal cells: in vitro effects of melatonin on progesterone secretion.
    Reproduction, fertility, and development, 2011, Volume: 23, Issue:3

    Topics: Animals; Blotting, Western; Cholesterol Side-Chain Cleavage Enzyme; Chorionic Gonadotropin; Colforsin; Female; Horses; Luteal Cells; Melatonin; Ovarian Follicle; Progesterone; Receptor, Melatonin, MT1; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Statistics, Nonparametric; Tryptamines

2011
Phosphorylation of cyclic AMP-response element-binding protein (CREB) is influenced by melatonin treatment in pancreatic rat insulinoma β-cells (INS-1).
    Journal of pineal research, 2012, Volume: 53, Issue:4

    Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cell Line, Tumor; Colforsin; Cyclic AMP Response Element-Binding Protein; Dose-Response Relationship, Drug; Fluorescent Antibody Technique; Humans; Insulin-Secreting Cells; Insulinoma; Melatonin; Microscopy, Confocal; Pancreatic Neoplasms; Phosphorylation; Rats; Receptor, Melatonin, MT1; Receptor, Melatonin, MT2; Signal Transduction; Tetrahydronaphthalenes; Time Factors; Transfection; Tryptamines

2012
The melatonin agonist ramelteon induces duration-dependent clock gene expression through cAMP signaling in pancreatic INS-1 β-cells.
    PloS one, 2014, Volume: 9, Issue:7

    Topics: Animals; ARNTL Transcription Factors; Cell Line; Colforsin; Cyclic AMP; Cyclic AMP Response Element-Binding Protein; Humans; Indenes; Insulin-Secreting Cells; Nuclear Receptor Subfamily 1, Group D, Member 1; Phosphorylation; Rats; Receptors, Melatonin; Tryptamines

2014