Page last updated: 2024-09-03

luzindole and 1-methyl-3-isobutylxanthine

luzindole has been researched along with 1-methyl-3-isobutylxanthine in 4 studies

Compound Research Comparison

Studies (luzindole)	Trials (luzindole)	Recent Studies (post-2010) (luzindole)	Studies (1-methyl-3-isobutylxanthine)	Trials (1-methyl-3-isobutylxanthine)	Recent Studies (post-2010) (1-methyl-3-isobutylxanthine)
265	1	119	5,148	5	279

Protein Interaction Comparison

Protein	Taxonomy	1-methyl-3-isobutylxanthine (IC50)
Chain A, High-affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A	Homo sapiens (human)	8.1
Chain A, cAMP-specific 3',5'-cyclic phosphodiesterase 4D	Homo sapiens (human)	31
Chain A, Phosphodiesterase 9A	Homo sapiens (human)	500
Chain A, Class I phosphodiesterase PDEB1	Leishmania major	580
Chain A, High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A	Homo sapiens (human)	698
Chain A, cGMP-dependent 3',5'-cyclic phosphodiesterase	Homo sapiens (human)	40
Chain A, High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	Homo sapiens (human)	117.2
Chain A, High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	Homo sapiens (human)	117.2
Phosphodiesterase	Bos taurus (cattle)	9.9
cGMP-dependent 3',5'-cyclic phosphodiesterase	Homo sapiens (human)	4
cGMP-specific 3',5'-cyclic phosphodiesterase	Homo sapiens (human)	3.1667
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	Bos taurus (cattle)	9.9
Adenosine receptor A1	Rattus norvegicus (Norway rat)	7
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	Homo sapiens (human)	3.4
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	Bos taurus (cattle)	9.9
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	Homo sapiens (human)	3.4
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	Rattus norvegicus (Norway rat)	0.1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	Homo sapiens (human)	0.242
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	Homo sapiens (human)	3.4
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	Homo sapiens (human)	7
Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C	Rattus norvegicus (Norway rat)	0.1
Phosphodiesterase	Rattus norvegicus (Norway rat)	0.1

Research

Studies (4)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	1 (25.00)	18.2507
2000's	2 (50.00)	29.6817
2010's	1 (25.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Gan, J; Iuvone, PM	1
Chankiewitz, E; Csernus, VJ; Mühlbauer, E; Musshoff, U; Peschke, D; Peschke, E	1
Mühlbauer, E; Peschke, E; Stumpf, I	1
Albrecht, E; Bazwinsky-Wutschke, I; Mühlbauer, E; Peschke, E; Wolgast, S	1

Other Studies

4 other study(ies) available for luzindole and 1-methyl-3-isobutylxanthine

Article	Year
Melatonin receptor-mediated inhibition of cyclic AMP accumulation in chick retinal cell cultures. Journal of neurochemistry, 1994, Volume: 63, Issue:1 Topics: 1-Methyl-3-isobutylxanthine; 5-Methoxytryptamine; Animals; Cells, Cultured; Chick Embryo; Colforsin; Cyclic AMP; Iodine Radioisotopes; Melatonin; Neurons; Pertussis Toxin; Photoreceptor Cells; Potassium; Receptors, Cell Surface; Receptors, Melatonin; Retina; Second Messenger Systems; Structure-Activity Relationship; Tryptamines; Virulence Factors, Bordetella	1994
Receptor (MT(1)) mediated influence of melatonin on cAMP concentration and insulin secretion of rat insulinoma cells INS-1. Journal of pineal research, 2002, Volume: 33, Issue:2 Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Animals; Biological Transport; Colforsin; Cyclic AMP; Cyclic AMP-Dependent Protein Kinases; Insulin; Insulin Secretion; Insulinoma; Islets of Langerhans; Melatonin; Pancreatic Neoplasms; Phosphodiesterase Inhibitors; Polymerase Chain Reaction; Probenecid; Rats; Receptors, Cell Surface; Receptors, Cytoplasmic and Nuclear; Receptors, Melatonin; Signal Transduction; Tryptamines; Tumor Cells, Cultured	2002
Involvement of the cGMP pathway in mediating the insulin-inhibitory effect of melatonin in pancreatic beta-cells. Journal of pineal research, 2008, Volume: 45, Issue:3 Topics: 1-Methyl-3-isobutylxanthine; Animals; Brain; Cell Line, Tumor; Colforsin; Cyclic GMP; Cyclic Nucleotide Phosphodiesterases, Type 2; Cyclic Nucleotide-Gated Cation Channels; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Glucose; Guanylate Cyclase; Insulin; Insulin Secretion; Insulin-Secreting Cells; Insulinoma; Melatonin; Pineal Gland; Rats; Rats, Wistar; Receptor, Melatonin, MT2; Signal Transduction; Tetrahydronaphthalenes; Tryptamines	2008
Phosphorylation of cyclic AMP-response element-binding protein (CREB) is influenced by melatonin treatment in pancreatic rat insulinoma β-cells (INS-1). Journal of pineal research, 2012, Volume: 53, Issue:4 Topics: 1-Methyl-3-isobutylxanthine; Animals; Calcium-Calmodulin-Dependent Protein Kinase Type 2; Cell Line, Tumor; Colforsin; Cyclic AMP Response Element-Binding Protein; Dose-Response Relationship, Drug; Fluorescent Antibody Technique; Humans; Insulin-Secreting Cells; Insulinoma; Melatonin; Microscopy, Confocal; Pancreatic Neoplasms; Phosphorylation; Rats; Receptor, Melatonin, MT1; Receptor, Melatonin, MT2; Signal Transduction; Tetrahydronaphthalenes; Time Factors; Transfection; Tryptamines	2012