lupane and n-hexane

A new pentacyclic triterpenoid fatty acid ester, lupan-20-ol-3(β)-yl hexadecanoate (1), together with lupan-20-ol-3(β)-yl acetate (2), olean-18-en-3(β)-yl hexadecanoate (3), dotriacontanoic acid (4), stigmasterol (5), rubiadin (6), nonadecanoic acid (7), palmitic acid (8) and camptothecin (9) were isolated from the hexane and chloroform extracts of Ophiorrhiza shendurunii from South India. Structures of the isolates were determined by (1)H, (13)C, (13)C DEPT, (1)H-(1)H COSY, HMBC, HSQC, NOESY NMR, FT-IR, DART-MS, ESI-MS, alkaline hydrolysis, derivatisation, GC-MS and HPTLC analyses. O. shendurunii hexane and chloroform extracts showed significant activities against Candida albicans and Fusarium oxysporum. Compounds 1 to 3 showed only moderate antiyeast/antifungal activities.

Topics: Antifungal Agents; Drug Evaluation, Preclinical; Fatty Acids; Gas Chromatography-Mass Spectrometry; Hexanes; Hydrolysis; India; Magnetic Resonance Spectroscopy; Microbial Sensitivity Tests; Molecular Structure; Plant Extracts; Rubiaceae; Spectrometry, Mass, Electrospray Ionization; Spectroscopy, Fourier Transform Infrared; Triterpenes