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lucanthone hydrochloride and pyrazines

lucanthone hydrochloride has been researched along with pyrazines in 76 studies

Research

Studies (76)

Timeframe	Studies, this research(%)	All Research%
pre-1990	48 (63.16)	18.7374
1990's	19 (25.00)	18.2507
2000's	9 (11.84)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Abbondandolo, A; Barale, R; Bartsch, H; Bonatti, S; Davis, A; Kuroki, T; Loprieno, N; Malaveille, C; Rainaldi, G; Vogel, E	1
Andrews, P; Gönnert, R	1
Carlos, MA; Lima-Costa, FF; Mello, RT; Pellegrino, J	1
James, C; Nelson, GS; Webbe, G	1
Bell, DR; Brown, MC; Chavasse, CJ	1
Lorke, D; Machemer, L	1
Andrews, P	1
Bennett, JL; Fetterer, R; Pax, R	1
James, C; Webbe, G	1
Fleury, MB	1
Nare, B; Prichard, RK; Smith, JM	4
Bouchard, L; Castonguay, A; Nicole, P; Pepin, P	1
Davies, MH; Schamber, GJ; Schnell, RC	1
Davies, MH; Schnell, RC	1
Aboul-Atta, AM	1
Aboul-Atta, AM; Awadallah, FE; el-Ahl, SS; Hamdy, BH; Hassan, ZA	2
Davidson, NE; Egner, PA; Kensler, TW	1
Mkoji, GM; Prichard, RK; Smith, JM	2
Fleury, MB; Leroy, JP; Martens, T; Moreau, N	1
Aboul-Atta, AM; el-Ahl, SS; Hassan, ZA	3
Aboul-Atta, AM; Zeedan, AH	2
Ali, HM; Bennett, JL; Homeida, MM; Sulaiman, SM	3
Ali, HM; Bennet, JL; Homeida, MM; Sulaiman, SM	1
Charmot, G; Coulaud, JP; Marche, C; Penalba, C; Saimot, AG	1
Daffalla, AA; el Tayeb, M; Fenwick, A; Kardaman, MW; See, R	1
Hu, YZ; Wang, GF; Yang, YQ; Zheng, H	1
Hassan, MM; Madwar, MA; Strickland, GT	1
Bruce, JI	1
Cornford, EM	1
Azoulay, M; Frappier, F; Leroy, JP	1
Bennett, JL; Morrison, DD; Semeyn, DR; Thompson, DP	1
Bruce, JI; Coles, GC; Dias, EP; Katz, N; Kinoti, GK; Mutahi, WT	1
Archer, S	1
Daffalla, AA; Dixon, HG; el Igail, AB; el Tayeb, M; Fenwick, A; Kardaman, MW	1
Bennett, JL; Daffalla, AA; el Igail, AB; el Tayeb, M; Fenwick, A; Kardaman, MW	1
Bieder, A; Bredenbac, J; Decouvelaere, B; Heusse, D; Jumeau, H; Leroy, JP; Marlard, M	1
Lei, XH; Xu, ML	1
Brücker, G; Danis, M; Duflo, B; Gentilini, M; Meunier, Y; Niel, G; Richard-Lenoble, D	1
Charmot, G; Mouchet, F; Rey, JL; Sellin, B; Sellin, E; Simonkovich, E	1
Baltes, R; Burchard, GD; Dietrich, M; Kern, P	1
Burchard, GD; Dietrich, M; Kern, P	1
Abaza, H; El-Kady, A; Wasfy, E	1
Ancelle, T; Dupouy-Camet, J; Faurant, C; Heyer, F; Keita, A; Lapierre, J; Tourte-Schaefer, C	1
Ali, HM; Bennett, JL; Gaillot, J; Sulaiman, SM	1
Cavier, R	1
Ahmed, MA; Bella, H; Bennett, JL; Mustafa, MD; Rahim, AG; Wasfi, S	1
Bueding, E; Dolan, P; Leroy, JP	1
Breuil, J; Charmot, G; Coulanges, P; Moyroud, J	1
Breuil, J; Coulanges, P; Moyroud, J; Raveloarison, G	1
Basset, P; Grégoire, J; Lancastre, F; Lesobre, B; Mafart, Y; Meyniel, D; Piéron, R; Renard, A; Simon, J	1
Cerf, P; Coulanges, P; Moyroud, J	1
Clapper, ML; Engstrom, PF; Everley, LC; Strobel, LA; Townsend, AJ	1
Abdel-Rahman, SZ; el-Kholy, Z; el-Sharkawy, A; el-Toukhy, M; el-Zoghby, S; Farag, H; Gaber, N	1
Helzlsouer, KJ; Kensler, TW	1
Baron, P; Chavan, SJ; Polsky, B; Prochaska, HJ	1
Ahmed, SA; Gad, MZ	1
Clapper, ML	1
Bu, SC; Kim, EJ; Kim, SG; Kim, SH; Lee, MG	1
Abdel-Hamid, MA; El-Bassiouni, EA; Helmy, MH; Ismail, SS; Shohayeb, MA	1
Bae, SK; Kim, SG; Lee, I; Lee, JY; Lee, MG; Lee, SJ; Lee, Y	1
Bae, SK; Kim, JW; Kim, T; Kwon, JW; Lee, MG; Yang, SH	1
Bae, SK; Kang, HE; Kang, MK; Kim, JW; Kim, T; Lee, MG	1
Bae, SK; Kim, JW; Kim, SG; Kim, T; Lee, I; Lee, MG; Lee, SJ	1
Gharibzadeh, S; Hoseini, SS; Mahdavi, S	1
Ahn, CY; Bae, SH; Bae, SK; Jung, YS; Kim, T; Kim, YC; Lee, MG; Shin, WG	1
Morsy, GH	1

Reviews

5 review(s) available for lucanthone hydrochloride and pyrazines

Article	Year
New anthelmintics. International journal for parasitology, 1987, Volume: 17, Issue:1 Topics: Albendazole; Animals; Anthelmintics; Benzimidazoles; Diphenylamine; Helminthiasis; Humans; Isothiocyanates; Ivermectin; Pyrazines; Schistosomicides; Thiocyanates; Thiones; Thiophenes	1987
The chemotherapy of schistosomiasis. Annual review of pharmacology and toxicology, 1985, Volume: 25 Topics: Animals; Chemical Phenomena; Chemistry; Diphenylamine; Humans; Hycanthone; Isothiocyanates; Niridazole; Oxamniquine; Praziquantel; Pyrazines; Schistosomiasis; Schistosomicides; Thiocyanates; Thiones; Thiophenes; Trichlorfon	1985
Oltipraz: clinical opportunities for cancer chemoprevention. p. Journal of cellular biochemistry. Supplement, 1995, Volume: 22 Topics: Animals; Anticarcinogenic Agents; Clinical Trials as Topic; Disease Models, Animal; Evaluation Studies as Topic; Humans; Liver Neoplasms; Pyrazines; Risk Factors; Schistosomicides; Thiones; Thiophenes	1995
Oltipraz, a novel inhibitor of human immunodeficiency virus type 1 (HIV-1) replication. Journal of cellular biochemistry. Supplement, 1995, Volume: 22 Topics: Acquired Immunodeficiency Syndrome; Acute Disease; Antiviral Agents; Clinical Trials as Topic; HIV-1; Humans; Pyrazines; Schistosomicides; Thiones; Thiophenes; Virus Replication	1995
Chemopreventive activity of oltipraz. Pharmacology & therapeutics, 1998, Volume: 78, Issue:1 Topics: Administration, Oral; Animals; Anticarcinogenic Agents; Biological Availability; Clinical Trials, Phase I as Topic; Clinical Trials, Phase II as Topic; Enzyme Induction; Glutamate-Cysteine Ligase; Glutathione Transferase; Humans; NAD(P)H Dehydrogenase (Quinone); Pyrazines; Reverse Transcriptase Inhibitors; Schistosomicides; Thiones; Thiophenes; Tissue Distribution	1998

Trials

7 trial(s) available for lucanthone hydrochloride and pyrazines

Article	Year
Praziquantel and oltipraz: the treatment of schoolchildren infected with Schistosoma mansoni and/or Schistosoma haematobium in Gezira, Sudan. Annals of tropical medicine and parasitology, 1988, Volume: 82, Issue:1 Topics: Child; Female; Humans; Male; Parasite Egg Count; Praziquantel; Pyrazines; Random Allocation; Recurrence; Schistosomiasis haematobia; Schistosomiasis mansoni; Schistosomicides; Sex Factors; Sudan; Thiones; Thiophenes	1988
Dose-finding trial using Oltipraz to treat schoolchildren infected with Schistosoma mansoni in Gezira, Sudan. The Journal of tropical medicine and hygiene, 1985, Volume: 88, Issue:2 Topics: Abdomen; Administration, Oral; Child; Clinical Trials as Topic; Feces; Fingers; Follow-Up Studies; Humans; Pain; Parasite Egg Count; Pyrazines; Schistosoma mansoni; Schistosomiasis; Schistosomicides; Thiones; Thiophenes; Vision Disorders	1985
Field trials with Oltipraz against Schistosoma mansoni in the Gezira Irrigated Area, Sudan. The Journal of tropical medicine and hygiene, 1985, Volume: 88, Issue:2 Topics: Child; Clinical Trials as Topic; Dose-Response Relationship, Drug; Feces; Humans; Parasite Egg Count; Pyrazines; Schistosoma mansoni; Schistosomiasis; Schistosomicides; Sudan; Thiones; Thiophenes	1985
Comparative trial of oltipraz versus praziquantel in the treatment of urinary schistosomiasis in the Gabon. Tropenmedizin und Parasitologie, 1984, Volume: 35, Issue:2 Topics: Adolescent; Child; Female; Gabon; Humans; Isoquinolines; Male; Parasite Egg Count; Praziquantel; Pyrazines; Schistosoma; Schistosoma haematobium; Schistosomiasis; Schistosomicides; Species Specificity; Thiones; Thiophenes; Urine; Urologic Diseases	1984
Comparative study of oltipraz versus praziquantel for treatment of schistosomiasis with intestinal manifestation in the Gabon (Schistosoma intercalatum and S. haematobium). Tropenmedizin und Parasitologie, 1984, Volume: 35, Issue:2 Topics: Adolescent; Child; Child, Preschool; Feces; Female; Gabon; Humans; Intestinal Diseases, Parasitic; Isoquinolines; Male; Parasite Egg Count; Praziquantel; Pyrazines; Schistosoma; Schistosoma haematobium; Schistosomiasis; Schistosomicides; Species Specificity; Thiones; Thiophenes	1984
Diet-controlled blood levels of oltipraz in healthy male subjects. The Journal of antimicrobial chemotherapy, 1984, Volume: 13, Issue:5 Topics: Adult; Biological Availability; Diet; Dietary Fats; Fasting; Humans; Kinetics; Male; Pyrazines; Schistosomicides; Thiones; Thiophenes	1984
Oltipraz--antischistosomal efficacy in Sudanese infected with Schistosoma mansoni. The American journal of tropical medicine and hygiene, 1982, Volume: 31, Issue:4 Topics: Administration, Oral; Adolescent; Adult; Child; Clinical Trials as Topic; Dose-Response Relationship, Drug; Feces; Humans; Male; Middle Aged; Parasite Egg Count; Pyrazines; Schistosoma mansoni; Schistosomiasis; Schistosomicides; Sudan; Thiones; Thiophenes	1982

Other Studies

64 other study(ies) available for lucanthone hydrochloride and pyrazines

Article	Year
Absence of mutagenicity of praziquantel, a new, effective, anti-schistosomal drug, in bacteria, yeasts, insects and mammalian cells. Mutation research, 1978, Volume: 58, Issue:2-3 Topics: Animals; Cell Line; Cricetinae; Drosophila melanogaster; Drug Evaluation, Preclinical; Genetic Techniques; Humans; Isoquinolines; Mutagens; Pyrazines; Saccharomyces cerevisiae; Salmonella typhimurium; Schistosomicides; Schizosaccharomyces	1978
Praziquantel, a new board-spectrum antischistosomal agent. Zeitschrift fur Parasitenkunde (Berlin, Germany), 1977, Jul-21, Volume: 52, Issue:2 Topics: Animals; Cricetinae; Female; Haplorhini; Isoquinolines; Male; Mice; Pyrazines; Schistosoma mansoni; Schistosomiasis; Schistosomicides	1977
Experimental chemotherapy of schistosomiasis mansoni. XIII. Activity of praziquantel, an isoquinoline-pyrazino derivative, on mice, hamsters and Cebus monkeys. Zeitschrift fur Parasitenkunde (Berlin, Germany), 1977, Jul-21, Volume: 52, Issue:2 Topics: Animals; Cricetinae; Haplorhini; Isoquinolines; Mice; Pyrazines; Schistosoma mansoni; Schistosomiasis; Schistosomicides	1977
The susceptibility to praziquantel of Schistosoma haematobium in the baboon (Papio anubis) and of S. japonicum in the vervet monkey (Cercopithecus aethiops). Zeitschrift fur Parasitenkunde (Berlin, Germany), 1977, Jul-21, Volume: 52, Issue:2 Topics: Animals; Chlorocebus aethiops; Haplorhini; Isoquinolines; Papio; Parasite Egg Count; Pyrazines; Schistosoma; Schistosoma haematobium; Schistosomiasis; Schistosomicides	1977
Schistosoma mansoni: activity responses in vitro to praziquantel. Zeitschrift fur Parasitenkunde (Berlin, Germany), 1979, Feb-28, Volume: 58, Issue:2 Topics: Animals; Dose-Response Relationship, Drug; In Vitro Techniques; Isoquinolines; Pyrazines; Schistosoma mansoni; Schistosomicides; Solutions; Time Factors	1979
Mutagenicity studies with praziquantel, a new anthelmintic drug, in mammalian systems. Archives of toxicology, 1978, Jan-25, Volume: 39, Issue:3 Topics: Animals; Cell Nucleus; Cricetinae; Cricetulus; Cyclophosphamide; Female; Genes, Dominant; Genes, Lethal; Isoquinolines; Male; Mice; Mutagens; Pregnancy; Pyrazines; Schistosomicides; Spermatogonia	1978
Effect of praziquantel on the free living stages of Schistosoma mansoni. Zeitschrift fur Parasitenkunde (Berlin, Germany), 1978, Jul-03, Volume: 56, Issue:1 Topics: Animals; Female; Isoquinolines; Mice; Pyrazines; Schistosoma mansoni; Schistosomiasis; Schistosomicides	1978
A benzodiazepine derivative and praziquantel: effects on musculature of Schistosoma mansoni and Schistosoma japonicum. Naunyn-Schmiedeberg's archives of pharmacology, 1978, Volume: 304, Issue:3 Topics: Animals; Benzodiazepinones; Calcium; Dopamine; Isoquinolines; Muscle Contraction; Muscles; Potassium; Pyrazines; Schistosoma japonicum; Schistosoma mansoni; Schistosomicides; Sodium; Time Factors	1978
A comparison of the susceptibility to praziquantel of Schistosoma haematobium, S. japonicum, S. mansoni, S. intercalatum and S. mattheei im hamsters. Zeitschrift fur Parasitenkunde (Berlin, Germany), 1977, Jul-21, Volume: 52, Issue:2 Topics: Animals; Cricetinae; Isoquinolines; Male; Pyrazines; Schistosoma; Schistosoma haematobium; Schistosoma mansoni; Schistosomiasis; Schistosomicides; Species Specificity	1977
[The role of electrochemical techniques in the understanding of the mechanism of drug actions. Example of an anti-Bilharzia agent]. Annales pharmaceutiques francaises, 1992, Volume: 50, Issue:4 Topics: Electrochemistry; Glutathione Reductase; In Vitro Techniques; Pyrazines; Schistosomicides; Thiones; Thiophenes	1992
Induction of glutathione S-transferase isoenzymes in mouse liver by 5-(2-pyrazynl)-4-methyl-1,2-dithiole-3-thione (oltipraz). Biochemical pharmacology, 1992, Feb-18, Volume: 43, Issue:4 Topics: Animals; Cytosol; Enzyme Induction; Glutathione Transferase; Isoenzymes; Liver; Mice; Pyrazines; Schistosomicides; Substrate Specificity; Thiones; Thiophenes	1992
Effects of sulindac and oltipraz on the tumorigenicity of 4-(methylnitrosamino)1-(3-pyridyl)-1-butanone in A/J mouse lung. Carcinogenesis, 1992, Volume: 13, Issue:3 Topics: Adenoma; Animals; Carcinogens; Drug Screening Assays, Antitumor; Female; Intestinal Absorption; Lung; Lung Neoplasms; Male; Mice; Mice, Inbred Strains; Nitrosamines; Oxidation-Reduction; Pyrazines; Schistosomicides; Sulindac; Thiones; Thiophenes	1992
Mechanisms of inactivation of Schistosoma mansoni and mammalian glutathione S-transferase activity by the antischistosomal drug oltipraz. Biochemical pharmacology, 1992, Mar-17, Volume: 43, Issue:6 Topics: Animals; Binding Sites; Dithiothreitol; Enzyme Activation; Ethylmaleimide; Glutathione Transferase; Humans; Pyrazines; Schistosoma mansoni; Schistosomicides; Thiones; Thiophenes	1992
Oltipraz-induced decrease in the activity of cytosolic glutathione S-transferase in Schistosoma mansoni. International journal for parasitology, 1991, Volume: 21, Issue:8 Topics: Animals; Cytosol; Glutathione Peroxidase; Glutathione Transferase; Isoenzymes; Male; Pyrazines; Schistosoma mansoni; Schistosomicides; Thiones; Thiophenes	1991
Differential effects of oltipraz and its oxy-analogue on the viability of Schistosoma mansoni and the activity of glutathione S-transferase. Biochemical pharmacology, 1991, Aug-22, Volume: 42, Issue:6 Topics: Animals; Dinitrochlorobenzene; Female; Glutathione; Glutathione Transferase; Kinetics; Male; Mice; Pyrazines; Schistosoma mansoni; Schistosomiasis mansoni; Schistosomicides; Tetrazolium Salts; Thiazoles; Thiones; Thiophenes	1991
Oltipraz-induced amelioration of acetaminophen hepatotoxicity in hamsters. I. Lack of dependence on glutathione. Toxicology and applied pharmacology, 1991, Jun-01, Volume: 109, Issue:1 Topics: Acetaminophen; Animals; Cricetinae; Glutathione; Glutathione Disulfide; Liver; Male; Mesocricetus; Oxidation-Reduction; Pyrazines; Schistosomicides; Thiones; Thiophenes	1991
Oltipraz-induced amelioration of acetaminophen hepatotoxicity in hamsters. II. Competitive shunt in metabolism via glucuronidation. Toxicology and applied pharmacology, 1991, Jun-01, Volume: 109, Issue:1 Topics: Acetaminophen; Animals; Cricetinae; Glutathione; Liver; Male; Mesocricetus; Models, Biological; Pyrazines; Schistosomicides; Thiones; Thiophenes; Uridine Diphosphate Glucuronic Acid	1991
The prophylactic and curative effect of oltipraz in experimental schistosomiasis mansoni in mice. Journal of the Egyptian Society of Parasitology, 1990, Volume: 20, Issue:1 Topics: Animals; Drug Administration Schedule; Male; Mice; Pyrazines; Schistosomiasis mansoni; Schistosomicides; Thiones; Thiophenes	1990
Oltipraz treatment in experimental schistosomiasis mansoni:VII. Effect of high dose oral therapy on alkaline phosphatase level in livers of infected mice. Journal of the Egyptian Society of Parasitology, 1990, Volume: 20, Issue:1 Topics: Alkaline Phosphatase; Animals; Liver; Male; Mice; Pyrazines; Schistosomiasis mansoni; Schistosomicides; Thiones; Thiophenes	1990
Transcriptional control of glutathione S-transferase gene expression by the chemoprotective agent 5-(2-pyrazinyl)-4-methyl-1,2-dithiole-3-thione (oltipraz) in rat liver. Cancer research, 1990, Apr-15, Volume: 50, Issue:8 Topics: Animals; Base Sequence; Enzyme Induction; Enzyme-Linked Immunosorbent Assay; Gene Expression Regulation, Enzymologic; Genes; Glutathione Transferase; Kinetics; Liver; Macromolecular Substances; Male; Methylation; Pyrazines; Rats; Rats, Inbred F344; Restriction Mapping; Schistosomicides; Thiones; Thiophenes; Transcription, Genetic	1990
Effect of oltipraz on the susceptibility of adult Schistosoma mansoni to killing by mouse peritoneal exudate cells. Parasitology research, 1990, Volume: 76, Issue:5 Topics: Animals; Glutathione; Immunity, Cellular; Mice; Mice, Inbred C57BL; Oxidation-Reduction; Peritoneal Cavity; Phagocytes; Pyrazines; Schistosoma mansoni; Schistosomicides; Thiones; Thiophenes	1990
Metabolism of oltipraz and glutathione reductase inhibition. Biochemical pharmacology, 1990, Sep-15, Volume: 40, Issue:6 Topics: Animals; Glutathione Reductase; Pyrazines; Schistosoma mansoni; Schistosomicides; Thiones; Thiophenes	1990
Oltipraz treatment in experimental schistosomiasis mansoni. I. Morphological changes among S. mansoni worms induced by high dose oral therapy in mice. Journal of the Egyptian Society of Parasitology, 1989, Volume: 19, Issue:1 Topics: Animals; Female; Male; Mice; Pyrazines; Schistosoma mansoni; Schistosomiasis mansoni; Schistosomicides; Thiones; Thiophenes	1989
Oltipraz treatment in experimental schistosomiasis mansoni. II. Effect of high dose oral therapy on worm load and process of copulation in infected mice. Journal of the Egyptian Society of Parasitology, 1989, Volume: 19, Issue:2 Topics: Animals; Female; Male; Mice; Pyrazines; Schistosoma mansoni; Schistosomiasis mansoni; Schistosomicides; Thiones; Thiophenes	1989
Oltipraz treatment in experimental schistosomiasis mansoni: III. Effect of high dose oral therapy on hepatic shift of worms and tissue bound ova pattern in infected mice. Journal of the Egyptian Society of Parasitology, 1989, Volume: 19, Issue:2 Topics: Animals; Liver; Male; Mice; Pyrazines; Schistosoma mansoni; Schistosomiasis mansoni; Schistosomicides; Thiones; Thiophenes	1989
Oltipraz treatment in experimental schistosomiasis mansoni: IV. Histopathological changes in the intestines of infected mice induced by high dose oral therapy. Journal of the Egyptian Society of Parasitology, 1989, Volume: 19, Issue:2 Suppl Topics: Animals; Intestine, Small; Male; Mice; Pyrazines; Schistosomiasis mansoni; Schistosomicides; Thiones; Thiophenes	1989
Oltipraz treatment in experimental schistosomiasis mansoni: V. Histopathological changes in the livers of infected mice induced by high dose oral therapy. Journal of the Egyptian Society of Parasitology, 1989, Volume: 19, Issue:2 Suppl Topics: Animals; Liver; Liver Diseases, Parasitic; Male; Mice; Pyrazines; Schistosomiasis mansoni; Schistosomicides; Thiones; Thiophenes	1989
Oltipraz treatment in experimental schistosomiasis mansoni: VI. Effect of high dose oral therapy on alkaline phosphatase level in the intestines of infected mice. Journal of the Egyptian Society of Parasitology, 1989, Volume: 19, Issue:2 Suppl Topics: Alkaline Phosphatase; Animals; Intestines; Male; Mice; Pyrazines; Schistosomiasis mansoni; Schistosomicides; Thiones; Thiophenes	1989
Glutathione redox state, lipid peroxide levels, and activities of glutathione enzymes in oltipraz-treated adult Schistosoma mansoni. Biochemical pharmacology, 1989, Dec-01, Volume: 38, Issue:23 Topics: Animals; Glutathione; Glutathione Peroxidase; Glutathione Reductase; Lipid Peroxides; Mice; Oxidation-Reduction; Pyrazines; Schistosoma mansoni; Schistosomiasis mansoni; Schistosomicides; Thiones; Thiophenes	1989
Measurement of peak blood levels of oltipraz in patients infected with S. mansoni: correlation with the drug's antischistosomal action. Annals of tropical medicine and parasitology, 1986, Volume: 80, Issue:3 Topics: Adolescent; Adult; Child; Dose-Response Relationship, Drug; Feces; Humans; Male; Parasite Egg Count; Pyrazines; Schistosomiasis mansoni; Schistosomicides; Thiones; Thiophenes	1986
Oltipraz: administration with food increases its anti-schistosomal activity. Transactions of the Royal Society of Tropical Medicine and Hygiene, 1986, Volume: 80, Issue:6 Topics: Administration, Oral; Adolescent; Adult; Biological Availability; Child; Feces; Food; Humans; Kinetics; Male; Middle Aged; Parasite Egg Count; Pyrazines; Schistosomiasis mansoni; Schistosomicides; Thiones; Thiophenes	1986
[Eosinophilic granulomatous hepatitis. Apropos of 3 cases]. Bulletin de la Societe de pathologie exotique et de ses filiales, 1987, Volume: 80, Issue:1 Topics: Adult; Chemical and Drug Induced Liver Injury; Eosinophilic Granuloma; Humans; Male; Pyrazines; Schistosomiasis haematobia; Schistosomicides; Thiones; Thiophenes	1987
[The therapeutic effectiveness of oltipraz on mice with Schistosomiasis japonica]. Yao xue xue bao = Acta pharmaceutica Sinica, 1988, Volume: 23, Issue:3 Topics: Animals; Mice; Pyrazines; Schistosomiasis japonica; Schistosomicides; Thiones; Thiophenes	1988
Circulating antigens for assessing cure in schistosomiasis mansoni. Transactions of the Royal Society of Tropical Medicine and Hygiene, 1988, Volume: 82, Issue:6 Topics: Adolescent; Adult; Antibodies, Helminth; Antigens, Helminth; Child; Enzyme-Linked Immunosorbent Assay; Feces; Female; Humans; Male; Oxamniquine; Parasite Egg Count; Praziquantel; Pyrazines; Schistosomiasis mansoni; Schistosomicides; Thiones; Thiophenes	1988
Oltipraz-induced reduction in schistosomal glucose utilization rates. The American journal of tropical medicine and hygiene, 1988, Volume: 38, Issue:2 Topics: Animals; Deoxyglucose; Female; Glucose; Male; Phosphorylation; Pyrazines; Schistosoma mansoni; Schistosomicides; Thiones; Thiophenes	1988
Effect of oltipraz on the metabolism of glutathione in Schistosoma mansoni. Biochemical pharmacology, 1988, Jul-15, Volume: 37, Issue:14 Topics: Animals; Cysteine; Glutathione; Glutathione Synthase; Pyrazines; Schistosoma mansoni; Schistosomicides; Thiones; Thiophenes	1988
Acute effects of oltipraz on adult Schistosoma mansoni and its antagonism in vitro. Biochemical pharmacology, 1987, Apr-01, Volume: 36, Issue:7 Topics: Animals; Biological Transport; Cysteine; Cystine; Glutathione; Kinetics; Male; Membrane Potentials; Mice; Pyrazines; Schistosoma mansoni; Schistosomicides; Thiones; Thiophenes	1987
Drug resistance in schistosomiasis. Transactions of the Royal Society of Tropical Medicine and Hygiene, 1986, Volume: 80, Issue:2 Topics: Animals; Drug Resistance; Mice; Oxamniquine; Praziquantel; Pyrazines; Schistosoma mansoni; Schistosomicides; Thiones; Thiophenes	1986
Disposition of 14C-oltipraz in animals. Pharmacokinetics in mice, rats and monkeys. Comparison of the biotransformation in the infected mouse and in the schistosomes. Arzneimittel-Forschung, 1985, Volume: 35, Issue:9 Topics: Animals; Biotransformation; Female; Macaca mulatta; Male; Mice; Pyrazines; Rats; Rats, Inbred Strains; Schistosoma mansoni; Schistosomiasis mansoni; Schistosomicides; Species Specificity; Thiones; Thiophenes	1985
[Chemotherapeutic studies on schistosomiasis. XXXVI. Synthesis of derivatives of 4-phenyl-and 4-allyl-5-(pyrazinyl-2)-1, 2, 4-triazole-3-thio-ketone]. Yao xue xue bao = Acta pharmaceutica Sinica, 1985, Volume: 20, Issue:2 Topics: Animals; Mice; Pyrazines; Schistosoma japonicum; Schistosomicides; Structure-Activity Relationship; Thiones; Triazoles	1985
Assessment of 35972 RP (oltipraz) a new antischistosomal drug against Schistosoma haematobium, Schistosoma mansoni, and Schistosoma intercalatum. Acta tropica, 1980, Volume: 37, Issue:3 Topics: Adolescent; Adult; Child; Drug Administration Schedule; Drug Tolerance; Humans; Pyrazines; Schistosoma haematobium; Schistosoma mansoni; Schistosomiasis; Schistosomicides; Thiones; Thiophenes	1980
[Urinary schistosomiasis. 1st trial of mass treatment in the field (Niger)]. La semaine des hopitaux : organe fonde par l'Association d'enseignement medical des hopitaux de Paris, 1983, Mar-10, Volume: 59, Issue:10 Topics: Adolescent; Adult; Age Factors; Child; Child, Preschool; Female; Humans; Infant; Male; Mass Screening; Niger; Parasite Egg Count; Pyrazines; Schistosomiasis; Schistosomicides; Sex Factors; Thiones; Thiophenes; Urinary Tract Infections	1983
The oral treatment of urinary schistosomiasis in Egyptian patients with 'Oltipraz'. Tropical and geographical medicine, 1984, Volume: 36, Issue:2 Topics: Administration, Oral; Adolescent; Adult; Follow-Up Studies; Humans; Parasite Egg Count; Pyrazines; Schistosoma haematobium; Schistosomiasis; Schistosomicides; Thiones; Thiophenes; Urologic Diseases	1984
[Treatment of 700 cases of bilharziasis with the new drugs oxamniquine, oltipraz, praziquantel]. Bulletin de la Societe de pathologie exotique et de ses filiales, 1983, Volume: 76, Issue:5 Topics: Adolescent; Adult; Child; Child, Preschool; Humans; Isoquinolines; Middle Aged; Nitroquinolines; Oxamniquine; Paris; Praziquantel; Pyrazines; Schistosoma haematobium; Schistosoma mansoni; Schistosomiasis; Schistosomicides; Thiones; Thiophenes; Togo	1983
Method for the determination of oltipraz, a new antischistosomal agent, in blood. Journal of chromatography, 1984, Feb-10, Volume: 305, Issue:2 Topics: Chromatography, Gas; Humans; Pyrazines; Schistosomicides; Thiones; Thiophenes	1984
Effect of cysteine on oltipraz blood levels in green monkeys (Cercopithecus aethiops). Chemotherapy, 1984, Volume: 30, Issue:4 Topics: Animals; Biological Availability; Chlorocebus aethiops; Cysteine; Diet; Female; Kinetics; Male; Pyrazines; Schistosomicides; Sex Characteristics; Thiones; Thiophenes	1984
[Praziquantel and oltipraz, 2 new polyvalent anthelmintics]. Bulletin de l'Academie nationale de medecine, 1982, Volume: 166, Issue:1 Topics: Animals; Anthelmintics; Humans; Isoquinolines; Mice; Praziquantel; Pyrazines; Rats; Schistosomiasis; Schistosomicides; Thiones; Thiophenes	1982
The antischistosomal activity of oltipraz. Research communications in chemical pathology and pharmacology, 1982, Volume: 37, Issue:2 Topics: Animals; Enzyme Induction; Female; Glutathione; Mice; Pyrazines; Schistosoma mansoni; Schistosomiasis; Schistosomicides; Structure-Activity Relationship; Thiones; Thiophenes; Time Factors	1982
[Treatment of bilharziasis in Madagascar. Use of oltipraz in mass campaign against S. mansoni and S. haematobium]. La Nouvelle presse medicale, 1982, Dec-11, Volume: 11, Issue:50 Topics: Humans; Madagascar; Pyrazines; Schistosoma haematobium; Schistosoma mansoni; Schistosomiasis; Schistosomicides; Thiones; Thiophenes	1982
[Mass treatment of urinary bilharziasis with a single dose of oltipraz in Madagascar]. Archives de l'Institut Pasteur de Madagascar, 1982, Volume: 50, Issue:1 Topics: Adolescent; Child; Child, Preschool; Female; Humans; Madagascar; Male; Pyrazines; Schistosomiasis; Schistosomicides; Thiones; Thiophenes; Urinary Tract Infections	1982
[Oltipraz in one-day treatment of Schistosoma haematobium bilharziasis (pharmacokinetic data, therapeutic effects)]. La Revue de medecine interne, 1981, Volume: 2, Issue:2 Topics: Drug Administration Schedule; Female; Humans; Kinetics; Male; Pyrazines; Schistosoma haematobium; Schistosomiasis; Schistosomicides; Thiones; Thiophenes	1981
[Therapy of Schistosoma mansoni bilharziasis with RP. 35972 (Oltipraz). Preliminary results of initial therapy in Madagascar]. Archives de l'Institut Pasteur de Madagascar, 1981, Volume: 48, Issue:1 Topics: Adult; Aged; Female; Humans; Madagascar; Male; Middle Aged; Pyrazines; Schistosoma mansoni; Schistosomiasis; Schistosomicides; Thiones; Thiophenes	1981
Coordinate induction of glutathione S-transferase alpha, mu, and pi expression in murine liver after a single administration of oltipraz. Molecular pharmacology, 1994, Volume: 45, Issue:3 Topics: Animals; Enzyme Induction; Female; Glutathione Transferase; Isoenzymes; Liver; Mice; Mice, Inbred ICR; Pyrazines; RNA; Schistosomicides; Thiones; Thiophenes	1994
An experimental study on the effect of praziquantel and oltipraz on some lysosomal enzymes. The Journal of tropical medicine and hygiene, 1993, Volume: 96, Issue:1 Topics: Animals; Follow-Up Studies; Glucuronidase; Liver; Lysosomes; Male; Mice; Naphthol AS D Esterase; Praziquantel; Pyrazines; Ribonucleases; Schistosomiasis mansoni; Schistosomicides; Thiones; Thiophenes	1993
Effect of schistosomal infection and its treatment on some key enzymes of glucose metabolism in mice livers. Arzneimittel-Forschung, 1995, Volume: 45, Issue:12 Topics: Animals; Body Weight; Citric Acid Cycle; Female; Glucose; Glycolysis; Liver; Liver Glycogen; Male; Mice; Organ Size; Oxamniquine; Pentose Phosphate Pathway; Praziquantel; Pyrazines; Schistosomiasis mansoni; Schistosomicides; Thiones; Thiophenes	1995
Stability, blood partition and protein binding of an antifibrotic agent, oltipraz. Research communications in molecular pathology and pharmacology, 2001, Volume: 109, Issue:5-6 Topics: Animals; Chromatography, High Pressure Liquid; Drug Stability; Humans; Protein Binding; Pyrazines; Rabbits; Rats; Schistosomicides; Serum Albumin; Thiones; Thiophenes	2001
In vitro effect of low concentrations of oltipraz on the antioxidant defence of mouse hepatocytes and Schistosoma mansoni worms. British journal of biomedical science, 2004, Volume: 61, Issue:1 Topics: Animals; Cells, Cultured; Hepatocytes; Mice; Oxidative Stress; Pyrazines; Schistosoma mansoni; Schistosomicides; Thiones; Thiophenes	2004
Pharmacokinetic changes of oltipraz after intravenous and oral administration to rats with liver cirrhosis induced by dimethylnitrosamine. International journal of pharmaceutics, 2004, May-04, Volume: 275, Issue:1-2 Topics: Administration, Oral; Animals; Area Under Curve; Blood Proteins; Dimethylnitrosamine; Injections, Intravenous; Liver Cirrhosis, Experimental; Male; Microsomes, Liver; Protein Binding; Pyrazines; Rats; Rats, Sprague-Dawley; Schistosomicides; Thiones; Thiophenes; Time Factors; Tissue Distribution	2004
Effects of cysteine on the pharmacokinetics of oltipraz in rats with protein-calorie malnutrition. Journal of pharmaceutical sciences, 2005, Volume: 94, Issue:7 Topics: Animals; Chromatography, High Pressure Liquid; Cysteine; Dose-Response Relationship, Drug; Injections, Intravenous; Male; Microsomes, Liver; Protein-Energy Malnutrition; Pyrazines; Rats; Rats, Sprague-Dawley; Schistosomicides; Thiones; Thiophenes	2005
Pharmacokinetics of oltipraz in mutant Nagase analbuminemic rats. Journal of pharmaceutical sciences, 2006, Volume: 95, Issue:5 Topics: Acetylglucosaminidase; Administration, Oral; Albumins; Animals; Area Under Curve; Blood Proteins; Cytochrome P-450 CYP1A2; Dialysis; Half-Life; Injections, Intravenous; Male; Microsomes, Liver; Mutation; Protein Binding; Pyrazines; Rats; Rats, Sprague-Dawley; Schistosomicides; Thiones; Thiophenes	2006
Pharmacokinetics and therapeutic effects of oltipraz after consecutive or intermittent oral administration in rats with liver cirrhosis induced by dimethylnitrosamine. Journal of pharmaceutical sciences, 2006, Volume: 95, Issue:5 Topics: Administration, Oral; Alkylating Agents; Animals; Area Under Curve; Chromatography, High Pressure Liquid; Creatinine; Dimethylnitrosamine; Half-Life; Hematocrit; Liver; Liver Cirrhosis; Male; Organ Size; Pyrazines; Rats; Rats, Wistar; Schistosomicides; Thiones; Thiophenes	2006
Oltipraz may be useful in the prevention or treatment of Alzheimer's disease. Medical hypotheses, 2007, Volume: 68, Issue:4 Topics: Alzheimer Disease; Animals; Humans; Mice; Neurodegenerative Diseases; Oxidative Stress; Pyrazines; Schistosomicides; Thiones; Thiophenes	2007
Pharmacokinetics of oltipraz in diabetic rats with liver cirrhosis. British journal of pharmacology, 2009, Volume: 156, Issue:6 Topics: Animals; Area Under Curve; Cytochrome P-450 Enzyme System; Diabetes Mellitus, Experimental; Liver; Liver Cirrhosis, Experimental; Pyrazines; Rats; Schistosomicides; Thiones; Thiophenes	2009
Parasitological and histo-pathological studies on schistosomiasis mansoni infected mice and treated with praziquatel and/or oltipraz. Journal of the Egyptian Society of Parasitology, 2009, Volume: 39, Issue:2 Topics: Animals; Drug Therapy, Combination; Humans; Liver; Male; Mice; Parasite Egg Count; Praziquantel; Pyrazines; Random Allocation; Schistosoma mansoni; Schistosomiasis mansoni; Schistosomicides; Thiones; Thiophenes; Treatment Outcome	2009