Page last updated: 2024-09-04

lubazodone hydrochloride and fluoxetine

lubazodone hydrochloride has been researched along with fluoxetine in 5 studies

Compound Research Comparison

Studies
(lubazodone hydrochloride)
Trials
(lubazodone hydrochloride)
Recent Studies (post-2010)
(lubazodone hydrochloride)
Studies
(fluoxetine)
Trials
(fluoxetine)
Recent Studies (post-2010) (fluoxetine)
120110,1001,6633,263

Protein Interaction Comparison

ProteinTaxonomylubazodone hydrochloride (IC50)fluoxetine (IC50)
Gamma-aminobutyric acid receptor subunit piHomo sapiens (human)5.2
Gamma-aminobutyric acid receptor subunit deltaHomo sapiens (human)5.2
5-hydroxytryptamine receptor 4Cavia porcellus (domestic guinea pig)0.119
Aldo-keto reductase family 1 member B1Rattus norvegicus (Norway rat)1.303
Muscarinic acetylcholine receptor M5Homo sapiens (human)1.358
Cytochrome P450 2D6Homo sapiens (human)0.7
Muscarinic acetylcholine receptor M1Homo sapiens (human)3.203
Gamma-aminobutyric acid receptor subunit alpha-1Homo sapiens (human)5.2
Alpha-2B adrenergic receptorHomo sapiens (human)1.528
Gamma-aminobutyric acid receptor subunit beta-1Homo sapiens (human)5.2
Gamma-aminobutyric acid receptor subunit gamma-2Homo sapiens (human)5.2
Muscarinic acetylcholine receptor M3Homo sapiens (human)3.595
AcetylcholinesteraseHomo sapiens (human)0.13
Prostaglandin G/H synthase 1Homo sapiens (human)6
Sodium-dependent noradrenaline transporter Homo sapiens (human)2.8332
Sodium-dependent dopamine transporterRattus norvegicus (Norway rat)6
5-hydroxytryptamine receptor 2AHomo sapiens (human)0.452
5-hydroxytryptamine receptor 2CHomo sapiens (human)0.1395
Gamma-aminobutyric acid receptor subunit beta-3Homo sapiens (human)5.2
Gamma-aminobutyric acid receptor subunit alpha-5Homo sapiens (human)5.2
Sodium-dependent serotonin transporterHomo sapiens (human)0.0342
Sodium-dependent serotonin transporterRattus norvegicus (Norway rat)0.0538
Cytochrome P450 2C19Homo sapiens (human)0.0525
Gamma-aminobutyric acid receptor subunit alpha-3Homo sapiens (human)5.2
Gamma-aminobutyric acid receptor subunit alpha-2Homo sapiens (human)5.2
Gamma-aminobutyric acid receptor subunit beta-2Homo sapiens (human)5.2
Gamma-aminobutyric acid receptor subunit alpha-4Homo sapiens (human)5.2
5-hydroxytryptamine receptor 6Homo sapiens (human)1.661
Gamma-aminobutyric acid receptor subunit epsilonHomo sapiens (human)5.2
Sodium-dependent dopamine transporter Homo sapiens (human)5.984
Potassium voltage-gated channel subfamily H member 2Homo sapiens (human)1.3513
Gamma-aminobutyric acid receptor subunit alpha-6Homo sapiens (human)5.2
Beta-2 adrenergic receptorCavia porcellus (domestic guinea pig)0.0094
Gamma-aminobutyric acid receptor subunit gamma-1Homo sapiens (human)5.2
Sigma non-opioid intracellular receptor 1Homo sapiens (human)0.6751
Gamma-aminobutyric acid receptor subunit gamma-3Homo sapiens (human)5.2
Gamma-aminobutyric acid receptor subunit thetaHomo sapiens (human)5.2

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (20.00)18.2507
2000's3 (60.00)29.6817
2010's1 (20.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Jung, ME; Kang, SY; Kim, HJ; Kim, J; Kim, MJ; Kim, MS; Lee, J; Lee, KN; Lee, M; Lee, SH; Park, EJ; Park, WK; Seo, HJ; Son, EJ1
Fujii, M; Hatanaka, K; Hattori, H; Koshiya, K; Nakato, K; Sonoda, R; Takeuchi, H; Yamaguchi, T; Yatsugi, S1
Hatanaka, K; Yamaguchi, T; Yatsugi, S2
Takeuchi, H; Yamaguchi, T; Yatsugi, S1

Other Studies

5 other study(ies) available for lubazodone hydrochloride and fluoxetine

ArticleYear
Design and synthesis of novel arylpiperazine derivatives containing the imidazole core targeting 5-HT(2A) receptor and 5-HT transporter.
    Journal of medicinal chemistry, 2011, Sep-22, Volume: 54, Issue:18

    Topics: Animals; Antidepressive Agents; Binding, Competitive; CHO Cells; Cricetinae; Cricetulus; Drug Design; Humans; Imidazoles; Male; Mice; Motor Activity; Piperazines; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2A; Selective Serotonin Reuptake Inhibitors; Serotonin 5-HT2 Receptor Antagonists; Serotonin Plasma Membrane Transport Proteins; Stereoisomerism; Structure-Activity Relationship

2011
Pharmacological studies on YM992, a novel antidepressant with selective serotonin re-uptake inhibitory and 5-HT2A receptor antagonistic activity.
    European journal of pharmacology, 1997, Jun-18, Volume: 329, Issue:1

    Topics: Animals; Citalopram; Fluoxetine; Learning; Mice; Mice, Inbred ICR; Morpholines; Olfactory Bulb; Oxotremorine; Rats; Rats, Wistar; Receptor, Serotonin, 5-HT2A; Receptors, Serotonin; Selective Serotonin Reuptake Inhibitors; Serotonin Antagonists; Tremor

1997
Effect of acute treatment with YM992 on extracellular serotonin levels in the rat frontal cortex.
    European journal of pharmacology, 2000, Apr-21, Volume: 395, Issue:1

    Topics: Analysis of Variance; Animals; Antidepressive Agents; Cerebral Cortex; Citalopram; Cyclohexanols; Dose-Response Relationship, Drug; Extracellular Space; Fluorobenzenes; Fluoxetine; Frontal Lobe; Male; Morpholines; p-Chloroamphetamine; Piperidines; Rats; Rats, Wistar; Serotonin; Serotonin Agents; Serotonin Antagonists; Synaptosomes; Tritium; Venlafaxine Hydrochloride

2000
Effect of acute treatment with YM992 on extracellular norepinephrine levels in the rat frontal cortex.
    European journal of pharmacology, 2000, Apr-21, Volume: 395, Issue:1

    Topics: Analysis of Variance; Animals; Antidepressive Agents; Citalopram; Cyclohexanols; Dose-Response Relationship, Drug; Extracellular Space; Fluorobenzenes; Fluoxetine; Frontal Lobe; Male; Morpholines; Norepinephrine; Piperidines; Rats; Rats, Wistar; Selective Serotonin Reuptake Inhibitors; Serotonin Antagonists; Venlafaxine Hydrochloride

2000
Effect of YM992, a novel antidepressant with selective serotonin re-uptake inhibitory and 5-HT 2A receptor antagonistic activity, on a marble-burying behavior test as an obsessive-compulsive disorder model.
    Japanese journal of pharmacology, 2002, Volume: 90, Issue:2

    Topics: Animals; Antidepressive Agents; Behavior, Animal; Citalopram; Disease Models, Animal; Dose-Response Relationship, Drug; Fluoxetine; Injections, Intraperitoneal; Male; Mice; Mice, Inbred ICR; Morpholines; Motor Activity; Obsessive-Compulsive Disorder; Receptor, Serotonin, 5-HT2A; Selective Serotonin Reuptake Inhibitors

2002