lu 25-109 has been researched along with xanomeline in 3 studies
| Studies (lu 25-109) | Trials (lu 25-109) | Recent Studies (post-2010) (lu 25-109) | Studies (xanomeline) | Trials (xanomeline) | Recent Studies (post-2010) (xanomeline) |
|---|---|---|---|---|---|
| 14 | 2 | 1 | 124 | 16 | 41 |
| Protein | Taxonomy | lu 25-109 (IC50) | xanomeline (IC50) |
|---|---|---|---|
| Muscarinic acetylcholine receptor M2 | Homo sapiens (human) | 0.1644 | |
| Muscarinic acetylcholine receptor M4 | Homo sapiens (human) | 0.0251 | |
| Muscarinic acetylcholine receptor M1 | Homo sapiens (human) | 1.3967 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (33.33) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 1 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Allen, JR; Bures, MG; Bymaster, F; Croy, CH; Evans, D; Felder, CC; Hansen, MM; Hitchcock, SA; Hoogestraat, PJ; Jamison, JA; Liu, B; McKinzie, DL; Okha-Mokube, FM; Rao, Z; Stratford, RE; Stuart Gregory, G; Turner, W; Watt, ML | 1 |
| Bymaster, FP; Calligaro, DO; Carter, PA; DeLapp, N; Fink-Jensen, A; Jeppesen, L; Mitch, CH; Peters, SC; Rimvall, K; Sauerberg, P; Shannon, HE; Sheardown, MJ; Ward, JS; Whitesitt, CA; Zhang, W | 1 |
| Anderton, BH; Dayanandan, R; Forlenza, OV; Lovestone, S; Olesen, OF; Spink, JM | 1 |
3 other study(ies) available for lu 25-109 and xanomeline
| Article | Year |
|---|---|
Design and synthesis of N-[6-(Substituted Aminoethylideneamino)-2-Hydroxyindan-1-yl]arylamides as selective and potent muscarinic M₁ agonists.
Topics: Amides; Animals; Dose-Response Relationship, Drug; Drug Design; Humans; Molecular Structure; Rats; Receptor, Muscarinic M1; Structure-Activity Relationship | 2015 |
Xanomeline compared to other muscarinic agents on stimulation of phosphoinositide hydrolysis in vivo and other cholinomimetic effects.
Topics: Animals; Binding, Competitive; Brain Chemistry; Bridged Bicyclo Compounds, Heterocyclic; Cholinergic Agents; Cholinesterase Inhibitors; Dihydropyridines; Dose-Response Relationship, Drug; Hydrolysis; Hypothermia; Imines; Lithium; Male; Mice; Mice, Inbred Strains; Muscarinic Agonists; Oximes; Parasympathomimetics; Phosphatidylinositols; Physostigmine; Pilocarpine; Pyridines; Quinuclidines; Radioligand Assay; Salivation; Tacrine; Tetrazoles; Thiadiazoles; Tremor | 1998 |
Muscarinic agonists reduce tau phosphorylation in non-neuronal cells via GSK-3beta inhibition and in neurons.
Topics: Acetylcholine; Alzheimer Disease; Amyloid beta-Protein Precursor; Animals; Binding Sites; Calcium-Calmodulin-Dependent Protein Kinases; Carbachol; Cells, Cultured; Fetus; Glycogen Synthase Kinase 3; Glycogen Synthase Kinases; Lithium Chloride; Microtubules; Muscarinic Agonists; Neurons; Phosphorylation; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; tau Proteins; Tetrazoles; Thiadiazoles | 2000 |