loxiglumide has been researched along with proglumide in 239 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 17 (7.11) | 18.7374 |
| 1990's | 193 (80.75) | 18.2507 |
| 2000's | 27 (11.30) | 29.6817 |
| 2010's | 2 (0.84) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Adler, G; Beglinger, C; Delco, F; Gyr, K; Hildebrand, P; Luo, H; Werth, B | 1 |
| Baum, F; Cantor, P; Choudhury, AR; Creutzfeldt, W; Ebert, R; Hoffmann, G; Nauck, MA; Schmidt, WE | 1 |
| Chijiiwa, Y; Harada, N; Misawa, T; Nawata, H; Yoshinaga, M | 1 |
| Jansen, JB; Jebbink, MC; Lamers, CB; Mooy, DM; Rovati, LC | 2 |
| Schmidt, WE | 1 |
| Jansen, JB; Jebbink, MC; Lamers, CB; Masclee, AA; Rovati, LC; Schipper, J; van der Kleij, FG | 1 |
| Beglinger, C; Drewe, J; Gyr, K; Hildebrand, P; Ketterer, S; Luo, H | 1 |
| Bekkering, M; Bonato, C; D'Amato, M; De Fazio, C; Festorazzi, S; Giacovelli, G; Malesci, A; Rovati, LC; Tacconi, M; Valentini, A | 1 |
| Funakoshi, A; Kono, A; Shimazoe, T | 1 |
| Bishop, LA; Black, JW; Gerskowitch, VP; Hull, RA; Shankley, NP | 1 |
| Miyazaki, N; Saito, Y; Tomioka, M; Yamamoto, M | 2 |
| Kurose, I; Miura, S; Nagata, H; Sekizuka, E; Serizawa, H; Suematsu, M; Tashiro, H; Tsuchiya, M; Yoshioka, M | 1 |
| Funakoshi, A; Kono, A | 1 |
| Lüthen, R; Niederau, C; Niederau, M; Rovati, L; Schwarzendrube, J; Strohmeyer, G | 1 |
| Choudhury, AR; Creutzfeldt, W; Fölsch, UR; Höcker, M; Nustede, R; Schafmayer, A; Schmidt, WE | 1 |
| Beglinger, C; Drewe, J; Gadient, A; Rovati, LC | 1 |
| Faber, S; Karaus, M; Niederau, C | 1 |
| Green, GM; Hatta, Y; Nakano, I; Taguchi, S | 1 |
| Almegård, B; Bill, A; Stjernschantz, J | 1 |
| Adler, G; Beglinger, C; Dahmen, G; Katschinski, M; Koop, H; Nustede, R; Reinshagen, M | 1 |
| Bauerfeind, P; Beglinger, C; Delco, F; Eberle, A; Gyr, K; Hasslocher, H; Hildebrand, P; Meier, R; Urscheler, N | 1 |
| Adler, G; Arnold, R; Beglinger, C; Braun, U; Koop, I; Reinshagen, M; Rovati, L; Schafmayer, A | 1 |
| Albano, O; Baldassarre, G; Belfiore, A; Palasciano, G; Portincasa, P | 1 |
| Choudhury, AR; Creutzfeldt, W; Fölsch, UR; Höcker, M; Nustede, R; Rovati, LC; Schleser, A; Schmidt, WE | 1 |
| Creutzfeldt, W; Fussek, M; Leonhardt, U; Seidensticker, F; Stöckmann, F | 1 |
| Berry, C; Johnston, S; Spencer, GS | 1 |
| Bruley des Varannes, S; Cloarec, D; Dubois, A; Galmiche, JP | 1 |
| Baba, N; Manabe, T; Nishimura, I; Tasi, Y; Tobe, T | 1 |
| Adler, G; Arnold, R; Beckh, K; Göke, R; Koop, I; Ruff, W | 1 |
| Beglinger, C; Fried, M; Jansen, JB; Keller, U; Lamers, CB; Schwizer, W | 1 |
| Choudhury, AR; Creutzfeldt, W; Fölsch, UR; Höcker, M; Nitsche, R; Nustede, R; Rovati, LC; Schleser, A; Schmidt, WE; Sostmann, H | 1 |
| Karaus, M; Niederau, C | 2 |
| Bennett, A; D'Amato, M; Stamford, IF | 1 |
| Lüthen, R; Niederau, C; Niederau, M; Schwarzendrube, J | 1 |
| Bangerter, U; Beglinger, C; Delco, F; Ensinck, JW; Hildebrand, P; Ketterer, S; Mossi, S | 1 |
| Beglinger, C; Bischof-Delaloye, A; Erlacher, U; Fried, M; Harder, F; Jansen, JB; Koerfer, J; Lamers, CB; Löchner, C; Schwizer, W | 1 |
| Chaussade, S | 1 |
| Albrecht, C; Beglinger, C; Gyr, K; Hildebrand, P; Meier, R; Studer, B; Thumshirn, M | 1 |
| Choudhury, AR; Creutzfeldt, W; Fölsch, UR; Höcker, M; Nitsche, R; Nustede, R; Rovati, LC; Schafmayer, A; Schleser, A; Schmidt, WE | 1 |
| Adler, G; Beglinger, C; Braun, U; Koop, I; Reinshagen, M; Schafmayer, A | 1 |
| Biliotti, D; Bontempo, I; Corazziari, E; De Medici, A; Pallotta, N; Ricci, R; Torsoli, A | 1 |
| Beglinger, C; Gyr, K; Hildebrand, P; Jansen, JB; Lamers, CB; Rovati, LC; Setnikar, I; Stalder, GA; Zuercher, M | 1 |
| Bonato, C; De Fazio, C; Festorazzi, S; Malesci, A; Rovati, L; Setnikar, I; Tacconi, M; Valentini, A | 1 |
| Baba, H; Fujimura, M; Toda, N | 1 |
| Konturek, SJ; Kopp, B; Kwiecien, N; Obtulowicz, W; Oleksy, J; Rovati, L | 1 |
| Fujii, M; Itoh, H; Nakamura, T; Okabayashi, Y; Otsuki, M; Tani, S | 1 |
| Douglas, BR; Jansen, JB; Jebbink, MC; Lamers, CB | 1 |
| Fujii, M; Fujisawa, T; Itoh, H; Koide, M; Nakamura, T; Okabayashi, Y; Otsuki, M; Tani, S | 1 |
| Barocelli, E; Grider, JR; Impicciatore, M; Makhlouf, GM; Morini, G | 1 |
| Jansen, JB; Jebbink, MC; Lamers, CB; Masclee, AA | 1 |
| Bastié, MJ; Pradayrol, L; Scemama, JL; Seva, C; Vaysse, N | 1 |
| Gabryelewicz, A; Konturek, SJ; Kulesza, E | 1 |
| Fanali, S; Farina, A; Nardi, A; Quaglia, MG | 1 |
| Grendell, JH; Niederau, C; Niederau, M; Strohmeyer, G | 1 |
| Baba, S; Fujii, M; Fujisawa, T; Koide, M; Nakamura, T; Okabayashi, Y; Otsuki, M; Tani, S | 2 |
| Beglinger, C; Hildebrand, P; Jansen, JB; Meyer, BM; Rovati, LC; Stalder, GA; Werth, BA; Zach, D | 1 |
| Adler, G; Beglinger, C; Dill, S; Meyer, B; Werth, B | 1 |
| Chisté, R; Giacovelli, G; Rovati, LC; Setnikar, I | 1 |
| Fujii, K; Kishimoto, M; Miyoshi, A | 1 |
| Adler, G; Arnold, R; Göke, B; Koop, I; Reinshagen, M; Rovati, LC; Schafmayer, A | 1 |
| Bogdal, J; Konturek, JW; Konturek, SJ; Kurek, A; Oleksy, J; Rovati, L | 1 |
| Douglas, BR; Jansen, JB; Jebbink, MC; Lamers, CB; Tjon a Tham, RT | 1 |
| Heintges, T; Niederau, C; Rovati, L; Strohmeyer, G | 1 |
| Moriyoshi, Y; Shimizu, K; Shiratori, K; Takeuchi, T; Watanabe, S | 1 |
| Chisté, R; Makovec, F; Rovati, LC; Setnikar, I; Warrington, SJ | 1 |
| Bani, M; Cereda, R; Chisté, R; Makovec, F; Pacini, MA; Revel, L; Setnikar, I | 2 |
| Beglinger, C; Gyr, K; Hildebrand, P; Köhler, E; Setnikar, I | 1 |
| Bani, M; Cereda, R; Chisté, R; Makovec, F; Pacini, MA; Revel, L; Rovati, LA; Rovati, LC; Setnikar, I | 1 |
| Domschke, W; Konturek, JW; Konturek, SJ | 2 |
| Domschke, W; Gillessen, A; Konturek, JW; Konturek, SJ | 1 |
| Kimura, I; Kimura, M; Wakasono, S | 1 |
| Almegård, B; Andersson, SE | 1 |
| Ito, H; Kadowaki, M; Matsuo, M; Nakarai, T; Sato, Y; Sogabe, H; Tokoro, K; Tomoi, M; Yoshida, K | 1 |
| Domschke, W; Gabryelewicz, A; Konturek, JW; Stoll, R | 1 |
| Kashima, K; Kataoka, K; Kato, M; Kuriyama, K; Mukainaka, T; Ohkuma, S | 1 |
| Brzozowski, T; Drozdowicz, D; Konturek, SJ; Pytko-Polonczyk, J | 1 |
| Funakoshi, A; Masuda, M; Miyasaka, K | 1 |
| Nakano, S; Otsuki, M; Tachibana, I | 3 |
| Moriyoshi, Y; Shiratori, K; Takeuchi, T; Watanabe, S | 1 |
| Hayakawa, T; Hirao, S; Kitagawa, M; Nakae, Y; Naruse, S; Yamamoto, R | 1 |
| Itoh, H; Koide, M; Okabayashi, Y; Otsuki, M; Tani, S | 1 |
| Bamba, T; Hosoda, S; Ishizuka, Y | 1 |
| Otsuki, M; Watanabe, N | 2 |
| Hayakawa, T; Kitagawa, M; Kondo, T; Naruse, S; Shibata, T; Tanikawa, M | 1 |
| Chang, TM; Chey, WY; Kim, CD; Lee, KY | 1 |
| Adler, G; Arnold, R; Beglinger, C; Dahmen, G; Katschinski, M; Reinshagen, M; Steinicke, C | 1 |
| Jansen, JB; Lamers, CB; Lieverse, RJ; Masclee, AA; Rovati, LC | 2 |
| Jansen, JB; Jebbink, MC; Lamers, CB; Lieverse, RJ; Masclee, AA; Rovati, LC | 1 |
| D'Amato, M; Rovati, LC | 1 |
| Konturek, JW | 1 |
| Funakoshi, A; Jimi, A; Mishima, Y; Miyasaka, K; Tomita, H | 1 |
| Badiali, D; Cicala, M; Corazziari, E; Diacinti, D; Torsoli, A | 1 |
| Gielkens, HA; Hopman, WP; Jansen, JB; Rovati, LC; Tangerman, A; van Schaik, A; Verhulst, ML | 1 |
| Bergin, A; French, SJ; Read, NW; Rovati, L; Sepple, CP | 1 |
| Fölsch, UR; Höcker, M; Hughes, J; Schmidt, WE | 1 |
| Domschke, W; Gabryelewicz, A; Gutwinska-Konturek, M; Konturek, JW; Konturek, SJ | 1 |
| Almegård, B; Bill, A | 1 |
| Fujii, K; Haruma, K; Kajiyama, G; Kishimoto, S; Kobayashi, H; Machino, H; Miyoshi, A | 1 |
| Chey, WY; Imamura, M; Yamauchi, H | 1 |
| Domschke, W; Konturek, JW; Konturek, SJ; Maczka, M; Stoll, R; Thor, P | 1 |
| Chang, TM; Chey, WY; Shimizu, K; Shiratori, K; Takeuchi, T; Watanabe, S | 1 |
| Chang, TM; Chey, WY; Dubois, A; Jin, HO; Lee, KY | 1 |
| Aufderhaar, U; Bauerfeind, P; Beglinger, C; Burckhardt, B; Delco, F; Ensinck, JW; Gyr, K; Ketterer, S; Meier, R | 1 |
| Creutzfeldt, W; Fölsch, UR; Holst, JJ; Nustede, R; Schenk, S; Schmidt, WE | 1 |
| Akiyama, T; Otsuki, M | 1 |
| Ballatori, N; Chey, WY; Li, P; Sztefko, K | 1 |
| Chang, TM; Chey, WY; Lee, KY; Lee, YL; Moriyasu, M | 1 |
| Mantovani, P; Milenov, K; Rakovska, A; Sgaragli, G; Valoti, M | 1 |
| Imaeda, H; Kimura, H; Miura, S; Ohkubo, N; Serizawa, H; Toda, K; Tso, P; Tsuchiya, M; Yoshioka, M | 1 |
| Blackmore, M; Doherty, E; Hirst, BH; Manning, JE | 1 |
| Beglinger, C; Drewe, J; Gutzwiller, JP; Hildebrand, P; Lauper, JZ; Rossi, L | 1 |
| Heintges, T; Lüthen, R; Niederau, C | 1 |
| Beglinger, C | 1 |
| Barbara, G; Barbara, L; Corinaldesi, R; De Giorgio, R; Franzoso, L; Go, VL; Morselli-Labate, AM; Ricci Maccarini, M; Rovati, LC; Stanghellini, V | 1 |
| Jansen, JB; Lamers, CB; Lieverse, RJ; Masclee, AA | 2 |
| Singer, MV; Teyssen, S | 1 |
| Ahluwalia, NK; D'Amato, M; Mesquita, MA; Rovati, LC; Thompson, DG; Troncon, LE | 1 |
| Domschke, W; Konturek, JW; Konturek, SJ; Stoll, R | 2 |
| Cann, PA; Rovati, LC; Smart, HL; Spiller, RC; Whorwell, PJ | 1 |
| Bekkering, M; Chua, AS; Keeling, PW; Rovati, LC | 1 |
| Jansen, JB; Jebbink, MC; Lamers, CB; Mooy, DM; Rovati, LC; van der Kleij, FG | 1 |
| Fukumoto, M; Hayashi, H; Imamura, M; Kawabata, K; Manabe, T; Masai, Y; Morimoto, H; Nio, Y; Tsubono, M | 1 |
| Milenov, K; Rakovska, A | 1 |
| Baba, N; Hayashi, H; Hosokawa, Y; Kawabata, K; Manabe, T; Masai, Y; Morimoto, H; Nio, Y; Tseng, CC; Tsubono, M | 1 |
| Jansen, JB; Lamers, CB; Masclee, AA; Rovati, LC | 1 |
| Heindges, T; Mecklenbeck, W; Niederau, C | 1 |
| Hamaoka, T; Hayakawa, T; Kitagawa, M; Kodaira, T; Kondo, T; Shibata, T; Tanikawa, M | 1 |
| Jansen, JB; Lamers, CB; Lieverse, RJ; Masclee, AA; Rovati, LC; Samson, L; van de Zwan, A | 1 |
| Domschke, W; Gutwinska-Konturek, M; Konturek, JW; Konturek, SJ; Stoll, R | 1 |
| Domschke, W; Gabryelewicz, A; Konturek, JW; Konturek, SJ; Kulesza, E | 1 |
| Funakoshi, A; Matsumoto, M; Miyasaka, K; Sazaki, N | 1 |
| Funakoshi, A; Miyasaka, K; Nakamura, E; Teraoka, H | 1 |
| Rakovska, A | 2 |
| Fujii, M; Hasegawa, H; Koide, M; Nakamura, T; Okabayashi, Y; Otsuki, M; Shirohara, H | 1 |
| D'Amato, M; Feinle, C; Read, NW | 1 |
| Brotschi, EA; Hilbinger, CL; Kahl, EA; Midis, NA; Vaules, WA | 1 |
| Iwabe, C; Moriyoshi, Y; Shiratori, K; Takeuchi, T; Watanabe, S | 1 |
| Arii, S; Funaki, N; Imamura, M; Imamura, T; Kohmoto, M; Ohshio, G; Okada, N; Sasaoki, T; Tanaka, J; Tanaka, T; Wang, ZH; Yoshida, M | 1 |
| Inoue, K; Kubota, Y; Ogura, M | 1 |
| Akiyama, T; Hirohata, Y; Otsuki, M; Shirohara, H; Tachibana, I; Yamamoto, M | 1 |
| Hashimoto, S; Inoue, T; Izumi, T; Koyama, T; Ohmori, T; Tsuchiya, K | 1 |
| Bielański, W; Domschke, W; Konturek, JW; Konturek, SJ | 1 |
| D'Amato, M; Kisfalvi, I; Scarpignato, C; Varga, G | 1 |
| Endo, T; Nagasaki, M; Taniguchi, H; Yazaki, N | 1 |
| Beglinger, C; Hartel, M; Niebergall-Roth, E; Riepl, RL; Singer, MV; Teyssen, S; Wetzel, D | 1 |
| Kimura, T; Nakano, I; Nawata, H; Song, W; Yamaguchi, H | 1 |
| Adorni Ugolotti, MC; Mantovani, P; Rakowska, A; Valoti, M | 1 |
| Arai, M; Mitamura, K; Omachi, H; Tsubo, K | 1 |
| Arnold, R; Begliner, C; D'Amato, M; Katschinski, M; Langbein, S; Schirra, J; Wank, U | 1 |
| Funakoshi, A; Kobayashi, S; Miyasaka, K; Ohta, M | 1 |
| Endo, T; Nagasaki, M; Shikano, T; Taniguchi, H; Yazaki, N; Yomota, E | 1 |
| Beglinger, C; Chari, S; Niebergall-Roth, E; Rausch, A; Riepl, RL; Singer, MV; Teyssen, S | 1 |
| Hanada, K; Hirata, M; Itoh, M; Kajiyama, G; Ooishi, H; Tsuchida, A | 1 |
| Kondo, T; Liu, F; Naruse, S; Ozaki, T; Sazi, T; Toda, Y | 1 |
| Bosshammer, A; Koop, H; Koop, I; Scheibner, J; Schindler, M; Stange, E | 1 |
| Czakó, L; Otsuki, M; Yamamoto, M | 1 |
| Endo, T; Kume, E; Nagasaki, M; Shikano, T; Taniguchi, H; Yomota, E | 1 |
| Di Prima, F; Militello, C; Pedrazzoli, S; Sperti, C | 1 |
| Baintner, K; Bardocz, S; Ewen, SW; Gelencsér, E; Grant, G; Pusztai, A | 1 |
| Abergel, A; Bommelaer, G; Boulant, J; D'Amato, M; Dapoigny, M; Mathieu, S | 1 |
| Barlow, J; D'Amato, M; Mesquita, MA; Rovati, LC; Thompson, DG; Troncon, LE | 1 |
| Herberg, L; Klonowski-Stumpe, H; Meereis-Schwanke, K; Niederau, C | 2 |
| Nio, Y; Tamura, K | 1 |
| Borovicka, J; D'Amato, M; Fried, M; Read, NW; Wells, AS | 1 |
| Arai, I; Hirai, Y; Ida, Y; Komatsu, Y; Kuroiwa, Y; Sasaki, K; Shingu, K; Taguchi, S; Yamamoto, T; Yamaura, H | 1 |
| Fujii, M; Kasai, H; Kimura, K; Ninomiya, K; Saeki, M; Saito, T; Wakatsuki, K | 1 |
| Boesiger, P; Borovicka, J; Crelier, G; D'Amato, M; Fraser, R; Fried, M; Kreiss, C; Kunz, P; Schwizer, W | 1 |
| Adler, G; Beckh, K; Dirks, A; Koop, H; Koop, I | 1 |
| Imoto, I; Jia, DM; Otsuki, M; Yamamoto, M | 1 |
| Fujii, M; Kasai, H; Kimura, K; Masuda, T; Nakagawa, T; Saeki, M; Saito, T; Ukai, K; Wakatsuki, K | 1 |
| de Boer, SY; Gielkens, HA; Lam, WF; Lamers, CB; Masclee, AA; Rovati, LC | 1 |
| Barrell, GK; Dynes, RA; Poppi, DP; Sykes, AR | 1 |
| Kihara, Y; Nakano, S; Otsuki, M | 1 |
| Fujii, M; Kasai, H; Kato, T; Kimura, K; Ninomiya, K; Saeki, M; Saito, T; Wakatsuki, K | 1 |
| Edano, K; Fujii, M; Kasai, H; Kato, T; Kimura, K; Ninomiya, K; Saeki, M; Saito, T; Wakatsuki, K | 1 |
| Fujii, M; Fukamizu, Y; Kanda, H; Kasai, H; Kimura, K; Nakajima, T; Saito, T | 1 |
| Fujii, M; Kasai, H; Kimura, K; Saito, T; Tominaga, K | 1 |
| Boesiger, P; Borovicka, J; Crelier, GR; Fried, M; Kreiss, C; Kunz, P; Schwizer, W | 1 |
| Chang, TM; Chey, WY; Coy, D; Lee, KY; Lee, ST; Li, P | 1 |
| Hayashi, K; Kannbe, M; Kishimoto, S | 1 |
| Biemond, I; Lamers, CB; Ledeboer, M; Masclee, AA | 1 |
| Azpiroz, F; Clavé, P; Cussó, X; D'Amato, M; Farré, A; González, A; Lluís, F; López, R; Moreno, A | 1 |
| Boeckxstaens, GE; D'Amato, M; Fakhry, N; Hirsch, DP; Holloway, RH; Tytgat, GN | 1 |
| Bruley Des Varannes, S; D'Amato, M; Galmiche, JP; Leray, V; Rozé, C; Scarpignato, C; Zerbib, F | 1 |
| Izumi, T | 1 |
| Domschke, W; Hengst, K; Konturek, JW; Konturek, SJ; Sito, E; Stachura, J | 1 |
| D'Amato, M; Dockray, GJ; Grazia Lucà, M; Jones, MN; McLaughlin, J; Thompson, DG | 1 |
| Brzozowska, I; Brzozowski, T; Hahn, EG; Konturek, PC; Konturek, SJ; Kwiecién, S; Pajdo, R | 1 |
| Feinle, C | 1 |
| Kimura, K; Saito, T; Satake, K | 1 |
| Fukamizu, Y; Funakoshi, A; Miyasaka, K | 1 |
| Harada, H; Ochi, K; Satake, K | 1 |
| Akiyama, T; Hirohata, Y; Kihara, Y; Otsuki, M; Tashiro, M | 1 |
| Pelosini, I; Scarpignato, C | 1 |
| Brzozowski, T; Drozdowicz, D; Hahn, EG; Konturek, PC; Konturek, SJ; Kwiecień, S; Pajdo, R | 1 |
| Beglinger, C; D'Amato, M; Drewe, J; Engel, R; Gutzwiller, JP; Matzinger, D; Orban, A; Rovati, L | 1 |
| Katschinski, M | 1 |
| Beglinger, C; D'Amato, M; Degen, L; Drewe, J; Duebendorfer, R; Matzinger, D; Meuli, J; Rovati, L; Ruckstuhl, N | 1 |
| Beglinger, C; Drewe, J; Gutzwiller, JP; Hildebrand, P; Ketterer, S; Krautheim, A | 1 |
| Capellà, G; Clavé, P; Farré, R; González, AA; Monés, J | 1 |
| Beglinger, C; D'Amato, M; Degen, L; Drewe, J; Matzinger, D | 1 |
| Hayakawa, T; Ishiguro, H; Ito, O; Jin, C; Kitagawa, M; Nakajima, M; Naruse, S | 1 |
| Domschke, W; Konturek, JW; Konturek, M; Konturek, SJ; Menzel, J; Stoll, R | 1 |
| Ajjan, R; D'Amato, M; Hussain, FN; Moustafa, M; Riley, SA; Trudgill, NJ | 1 |
| Boeckxstaens, GE; Hirsch, DP; Tytgat, GN | 1 |
| Itho, M; Matsuda, S; Ogura, Y; Sasaki, H; Shimomura, M; Tanigawa, K | 1 |
| Matsuno, S; Satake, K; Shiratori, K; Takeuchi, T | 1 |
| Capellà, G; Clavé, P; Estorch, M; Greeley, GH; Hidalgo, L; Lluís, F; Rodríguez-Espinosa, J; Rovati, L | 1 |
| Boeckxstaens, GE; D'Amato, M; Fakhry, N; Hirsch, DP; Holloway, RH; Mathus-Vliegen, EM | 1 |
| Ishizaki, K; Kawamura, M; Kimura, K; Kinbara, S; Shiratori, K; Takeuchi, T | 1 |
| Akiyama, T; Fukumitsu, K; Jia, DM; Otani, M; Otsuki, M; Yamamoto, M; Yoshikawa, H | 1 |
| D'Amato, M; Malesci, A; Pezzilli, R; Rovati, L | 1 |
| Brzozowski, T; Drozdowicz, D; Hahn, EG; Konturek, PC; Konturek, SJ; Kwiecien, S; Moran, AP; Pajdo, R; Pawlik, WW; Sliwowski, Z | 1 |
| Anzini, M; Cappelli, A; De Sarro, G; Makovec, F; Monforte, F; Procopio, S; Rizzo, M; Ventrice, D | 1 |
| Funayama, Y; Matsuno, S; Naito, H; Sasaki, I; Shibata, C; Takahashi, M | 1 |
| Mostofsky, DI; Yehuda, S | 1 |
| D'Orazio, G; Fanali, S; Quaglia, MG; Rocco, A | 1 |
| Kuroda, Y; Takase, K; Ueda, T | 1 |
| Feinle-Bisset, C; Horowitz, M; Little, TJ | 1 |
| Kanemitsu, D; Kataoka, K; Motoyoshi, T; Nakajima, T; Sakagami, J | 1 |
| Aloj, L; De Luca, S; Lassiani, L; Morelli, G; Saviano, M; Stefanidou, P; Varnavas, A; Yannakopoulou, K | 1 |
| Chua, AS; Keeling, PW | 1 |
| Kanai, S; Miyasaka, K; Ohta, M; Suwa, Y; Tsutsumi, E | 1 |
| Duzman, R; Gonullu, D; Nihat Koksoy, F; Orhan Gurer, A; Sit, M; Yilmaz, N; Yucel, T | 1 |
| Jia, D; Otsuki, M; Yamamoto, M | 1 |
13 review(s) available for loxiglumide and proglumide
| Article | Year |
|---|---|
[Cholecystokinin and its antagonists: effects on digestive motility].
Topics: Benzodiazepinones; Brain; Cholecystokinin; Devazepide; Esophagus; Gallbladder; Gastric Emptying; Gastrointestinal Motility; Humans; Proglumide; Receptors, Cholecystokinin | 1991 |
Cholecystokinin in the control of gastric acid and plasma gastrin and somatostatin secretion in healthy subjects and duodenal ulcer patients before and after eradication of Helicobacter pylori.
Topics: Adult; Anti-Bacterial Agents; Cholecystokinin; Dietary Fats; Duodenal Ulcer; Eating; Gastric Acid; Gastrins; Helicobacter Infections; Helicobacter pylori; Hormones; Humans; Hydrogen-Ion Concentration; Male; Proglumide; Reference Values; Somatostatin | 1994 |
Role of cholecystokinin in the control of gastric acid secretion and gastrin release in dogs and healthy and duodenal ulcer subjects.
Topics: Animals; Cholecystokinin; Dogs; Duodenal Ulcer; Gastric Acid; Gastrins; Humans; Proglumide; Receptors, Cholecystokinin; Somatostatin | 1993 |
Effects of CCK on pancreatic function and morphology.
Topics: Animals; Cholecystokinin; Eating; Gallbladder; Humans; Islets of Langerhans; Pancreas; Proglumide | 1994 |
Effect of cholecystokinin on gastric motility in humans.
Topics: Benzodiazepinones; Cholecystokinin; Colon; Devazepide; Digestive System; Digestive System Physiological Phenomena; Duodenum; Gastric Emptying; Gastrointestinal Motility; Humans; Ileum; Infusions, Intravenous; Proglumide; Receptors, Cholecystokinin; Sincalide | 1994 |
Role of cholecystokinin in the regulation of satiation and satiety in humans.
Topics: Animals; Cholecystokinin; Humans; Infusions, Intravenous; Proglumide; Receptors, Cholecystokinin; Satiation; Satiety Response | 1994 |
[Newly-developing therapies of pancreatic cancer--immunotherapy, gene therapy, differentiation therapy, endocrine therapy and others].
Topics: Animals; Benzodiazepinones; Deuterium Oxide; Devazepide; Genetic Therapy; Humans; Immunotherapy; Pancreatic Neoplasms; Proglumide; Quinolones; Receptors, Cholecystokinin | 1997 |
Management of irritable bowel syndrome: novel approaches to the pharmacology of gut motility.
Topics: Animals; Cisapride; Colonic Diseases, Functional; Erythromycin; Gastrointestinal Agents; Gastrointestinal Motility; Hormone Antagonists; Humans; Octreotide; Parasympatholytics; Proglumide; Receptors, Adrenergic, beta; Receptors, Cholecystokinin; Receptors, Muscarinic; Receptors, Neurokinin-2; Receptors, Serotonin; Serotonin Antagonists | 1999 |
Nutritional implications of cephalic phase gastrointestinal responses.
Topics: Animals; Atropine; Digestion; Digestive System Physiological Phenomena; Eating; Gastric Acid; Gastrointestinal Hormones; Hormone Antagonists; Humans; Motor Neurons; Nutritional Physiological Phenomena; Parasympatholytics; Proglumide | 2000 |
Transient lower oesophageal sphincter relaxations--a pharmacological target for gastro-oesophageal reflux disease?
Topics: Atropine; Baclofen; Endoscopy, Gastrointestinal; Esophagogastric Junction; Fundoplication; GABA Agonists; Gastroesophageal Reflux; Hormone Antagonists; Humans; Parasympatholytics; Proglumide; Vagus Nerve | 2002 |
[New aspects of pharmaco-therapy for acute pancreatitis].
Topics: Acute Disease; Animals; Blood Proteins; Clinical Trials as Topic; Drug Design; Humans; Imidazoles; Leucine; Octreotide; Pancreatitis; Platelet Activating Factor; Proglumide; Pyridines; Receptor, Cholecystokinin A; Somatostatin | 2004 |
Role of cholecystokinin in appetite control and body weight regulation.
Topics: Animals; Appetite; Body Weight; Cholecystokinin; Digestive System Physiological Phenomena; Energy Intake; Gastrointestinal Hormones; Hormone Antagonists; Humans; Obesity; Proglumide; Receptors, Cholecystokinin | 2005 |
Cholecystokinin hyperresponsiveness in functional dyspepsia.
Topics: Atropine; Cholecystokinin; Dyspepsia; Efferent Pathways; Food Hypersensitivity; Gastrointestinal Motility; Gastrointestinal Tract; Humans; Norepinephrine; Proglumide; Receptors, Adrenergic; Receptors, Serotonin; Serotonin; Stress, Psychological | 2006 |
54 trial(s) available for loxiglumide and proglumide
| Article | Year |
|---|---|
Postprandial control of gallbladder contraction and exocrine pancreatic secretion in man.
Topics: Adult; Amylases; Atropine; Cholecystokinin; Eating; Gallbladder; Humans; Lipase; Male; Pancreas; Proglumide | 1992 |
Effect of loxiglumide on basal and gastrin- and bombesin-stimulated gastric acid and serum gastrin levels.
Topics: Adult; Bombesin; Cholecystokinin; Female; Gastric Acid; Gastrins; Humans; Male; Proglumide; Receptors, Cholecystokinin | 1992 |
Dose-response effects of oral loxiglumide on postprandial gall-bladder emptying in man.
Topics: Adult; Cholecystokinin; Dose-Response Relationship, Drug; Double-Blind Method; Food; Gallbladder; Gallbladder Emptying; Humans; Male; Proglumide | 1992 |
Role of circulating cholecystokinin in control of fat-induced inhibition of food intake in humans.
Topics: Adult; Cholecystokinin; Dietary Fats; Eating; Energy Intake; Feeding Behavior; Humans; Male; Proglumide; Receptors, Cholecystokinin; Satiation | 1992 |
Cholecystokinin's role in regulation of colonic motility in health and in irritable bowel syndrome.
Topics: Adult; Ceruletide; Cholecystokinin; Colon; Colonic Diseases, Functional; Female; Gastrointestinal Motility; Humans; Male; Proglumide; Receptors, Cholecystokinin | 1992 |
Cholecystokinin receptor antagonist loxiglumide modulates plasma levels of gastro-entero-pancreatic hormones in man. Feedback control of cholecystokinin and gastrin secretion.
Topics: Adult; Cholecystokinin; Eating; Feedback; Gastrins; Hormones; Humans; Male; Proglumide; Receptors, Cholecystokinin | 1991 |
Physiological role of cholecystokinin on postprandial insulin secretion and gastric meal emptying in man. Studies with the cholecystokinin receptor antagonist loxiglumide.
Topics: Adult; C-Peptide; Cholecystokinin; Dietary Carbohydrates; Eating; Gastric Emptying; Glucose; Humans; Infusions, Intravenous; Insulin; Insulin Secretion; Middle Aged; Proglumide; Receptors, Cholecystokinin; Time Factors | 1991 |
Effect of a cholecystokinin antagonist on meal-stimulated insulin and pancreatic polypeptide release in humans.
Topics: Adult; Amino Acids; Cholecystokinin; Female; Food; Humans; Infusions, Intravenous; Insulin; Male; Pancreas; Pancreatic Polypeptide; Proglumide; Receptors, Cholecystokinin | 1991 |
Role of cholecystokinin in the regulation of gastric emptying and pancreatic enzyme secretion in humans. Studies with the cholecystokinin-receptor antagonist loxiglumide.
Topics: Adult; Cholecystokinin; Gastric Emptying; Humans; Lipase; Middle Aged; Pancreas; Pancreatic Polypeptide; Proglumide; Trypsin | 1991 |
Cholecystokinin receptor antagonist loxiglumide: influence on bilio-pancreatic secretion and gastrointestinal hormones in man.
Topics: Adult; Cholecystokinin; Gallbladder; Humans; Male; Muscle Contraction; Muscle, Smooth; Pancreas; Proglumide; Radioimmunoassay; Receptors, Cholecystokinin | 1990 |
Oral administration of loxiglumide (CCK antagonist) inhibits postprandial gallbladder contraction without affecting gastric emptying.
Topics: Administration, Oral; Adult; Cholecystokinin; Double-Blind Method; Female; Food; Gallbladder; Gastric Emptying; Glutamine; Humans; Male; Muscle Contraction; Proglumide; Random Allocation | 1990 |
Lack of effect of the specific cholecystokinin receptor antagonist loxiglumide on cholecystokinin clearance from plasma in man.
Topics: Adult; Cholecystokinin; Female; Glutamine; Half-Life; Humans; Male; Proglumide | 1990 |
Role of cholecystokinin in regulation of gastrointestinal motor functions.
Topics: 4-Aminobenzoic Acid; Administration, Oral; Adult; Cholecystokinin; Clinical Trials as Topic; Colon; Drug Evaluation; Eating; Gallbladder; Gastric Emptying; Gastrointestinal Transit; Homeostasis; Humans; Infusions, Intravenous; Intestine, Small; Male; para-Aminobenzoates; Proglumide; Random Allocation; Receptors, Cholecystokinin | 1989 |
Effects of loxiglumide on gallbladder emptying in healthy volunteers.
Topics: Adult; Ceruletide; Cholecystokinin; Food; Gallbladder; Humans; Infusions, Intravenous; Male; Proglumide; Receptors, Cholecystokinin | 1989 |
Gastrointestinal motor and secretory responses to cholinergic stimulation in humans. Differential modulation by muscarinic and cholecystokinin receptor blockade.
Topics: Adult; Atropine; Bethanechol; Cholinergic Agents; Cholinergic Agonists; Duodenum; Gastrins; Gastrointestinal Motility; Humans; Male; Muscarinic Antagonists; Pancreas; Pancreatic Polypeptide; Proglumide; Pyloric Antrum; Receptors, Cholecystokinin; Time Factors | 1995 |
Satiety effects of the type A CCK receptor antagonist loxiglumide in lean and obese women.
Topics: Adult; Appetite; Double-Blind Method; Female; Humans; Hunger; Infusions, Intravenous; Middle Aged; Obesity; Proglumide; Receptor, Cholecystokinin A; Receptors, Cholecystokinin; Satiety Response | 1995 |
Effects of somatostatin and loxiglumide on gallbladder motility.
Topics: Adult; Cholecystokinin; Double-Blind Method; Female; Gallbladder; Humans; Male; Proglumide; Somatostatin | 1995 |
Cholecystokinin in the control of gastric acid and plasma gastrin and somatostatin secretion in healthy subjects and duodenal ulcer patients before and after eradication of Helicobacter pylori.
Topics: Adult; Anti-Bacterial Agents; Cholecystokinin; Dietary Fats; Duodenal Ulcer; Eating; Gastric Acid; Gastrins; Helicobacter Infections; Helicobacter pylori; Hormones; Humans; Hydrogen-Ion Concentration; Male; Proglumide; Reference Values; Somatostatin | 1994 |
Effect of endogenous cholecystokinin on postprandial gallbladder refilling. Ultrasonographic study in healthy subjects and in gallstone patients.
Topics: Adult; Cholecystokinin; Cholelithiasis; Double-Blind Method; Eating; Female; Gallbladder; Gallbladder Emptying; Humans; Male; Proglumide; Ultrasonography | 1995 |
Loxiglumide inhibits cholecystokinin stimulated somatostatin secretion and simultaneously enhances gastric acid secretion in humans.
Topics: Adult; Cholecystokinin; Female; Gastric Acid; Gastric Mucosa; Humans; Infusions, Intravenous; Male; Proglumide; Receptors, Cholecystokinin; Somatostatin; Time Factors | 1994 |
The effects of loxiglumide on food intake in normal weight volunteers.
Topics: Adolescent; Adult; Body Mass Index; Cholecystokinin; Cross-Over Studies; Double-Blind Method; Eating; Female; Humans; Hunger; Male; Proglumide; Satiation | 1994 |
Role of cholecystokinin in the control of gastric emptying and secretory response to a fatty meal in normal subjects and duodenal ulcer patients.
Topics: Adult; Cholecystokinin; Dietary Fats; Duodenal Ulcer; Gastric Acid; Gastric Emptying; Gastrins; Humans; Hydrogen-Ion Concentration; Male; Pancreatic Polypeptide; Proglumide; Receptors, Cholecystokinin; Somatostatin | 1994 |
Cholecystokinin is a physiological regulator of gastric acid secretion in man.
Topics: Adult; Cholecystokinin; Dose-Response Relationship, Drug; Drug Interactions; Eating; Gastric Acid; Gastric Mucosa; Gastrins; Homeostasis; Hormones; Humans; Male; Middle Aged; Proglumide; Sincalide; Somatostatin | 1994 |
Cholecystokinin is a negative regulator of gastric acid secretion and postprandial release of gastrin in humans.
Topics: Adult; Cholecystokinin; Eating; Gastric Acid; Gastric Mucosa; Gastrins; Humans; Male; Proglumide; Radioimmunoassay; Receptors, Cholecystokinin; Somatostatin; Stomach | 1994 |
Effect of intravenous human gastrin-releasing peptide on food intake in humans.
Topics: Adult; Cholecystokinin; Dose-Response Relationship, Drug; Double-Blind Method; Eating; Gastrin-Releasing Peptide; Gastrins; Humans; Infusions, Intravenous; Longitudinal Studies; Male; Peptides; Proglumide; Satiation; Time Factors | 1994 |
Effect of a low dose of intraduodenal fat on satiety in humans: studies using the type A cholecystokinin receptor antagonist loxiglumide.
Topics: Adult; Cholecystokinin; Duodenum; Eating; Fat Emulsions, Intravenous; Female; Humans; Hunger; Male; Proglumide; Receptors, Cholecystokinin; Satiation; Time Factors | 1994 |
Loxiglumide, a CCK-A antagonist, in irritable bowel syndrome. A pilot multicenter clinical study.
Topics: Administration, Oral; Colonic Diseases, Functional; Diarrhea; Dose-Response Relationship, Drug; Pilot Projects; Proglumide; Receptors, Cholecystokinin | 1994 |
Clinical efficacy and prokinetic effect of the CCK-A antagonist loxiglumide in nonulcer dyspepsia.
Topics: Adult; Analysis of Variance; Double-Blind Method; Dyspepsia; Female; Gastric Emptying; Humans; Male; Middle Aged; Proglumide; Receptors, Cholecystokinin; Sincalide; Time Factors | 1994 |
Effect of duodenal juice on bombesin-stimulated cholecystokinin release during loxiglumide administration in man.
Topics: Adult; Bombesin; Cholecystokinin; Female; Humans; Infusions, Intravenous; Male; Pancreatic Juice; Proglumide | 1993 |
Bombesin reduces food intake after a preload in man by a cholecystokinin-independent mechanism.
Topics: Adult; Bombesin; Cholecystokinin; Double-Blind Method; Eating; Energy Intake; Feeding Behavior; Female; Humans; Infusions, Intravenous; Proglumide | 1993 |
Bombesin reduces food intake in lean man by a cholecystokinin-independent mechanism.
Topics: Adult; Bombesin; Cholecystokinin; Drug Combinations; Eating; Female; Humans; Male; Osmolar Concentration; Proglumide; Satiety Response | 1993 |
Oral glucose ingestion stimulates cholecystokinin release in normal subjects and patients with non-insulin-dependent diabetes mellitus.
Topics: Administration, Oral; Adult; Atropine; Blood Glucose; Case-Control Studies; Cholecystokinin; Diabetes Mellitus, Type 2; Dose-Response Relationship, Drug; Female; Glucose; Hormone Antagonists; Humans; Insulin; Male; Middle Aged; Proglumide; Radioimmunoassay; Receptors, Cholecystokinin | 1996 |
Cholecystokinin-A receptors modulate gastric sensory and motor responses to gastric distension and duodenal lipid.
Topics: Adult; Analysis of Variance; Chi-Square Distribution; Duodenum; Fat Emulsions, Intravenous; Female; Gastric Dilatation; Gastric Mucosa; Gastrointestinal Motility; Hormone Antagonists; Humans; Male; Nausea; Pressure; Proglumide; Receptors, Cholecystokinin; Sensation; Stomach | 1996 |
Eradication of Helicobacter pylori and gastrin-somatostatin link in duodenal ulcer patients.
Topics: Adult; Cholecystokinin; Duodenal Ulcer; Gastric Acid; Gastric Mucosa; Gastrins; Helicobacter Infections; Helicobacter pylori; Hormone Antagonists; Humans; Male; Proglumide; Somatostatin | 1996 |
Intestinal phase of human antro-pyloro-duodenal motility: cholinergic and CCK-mediated regulation.
Topics: Acetylcholine; Adult; Atropine; Cholecystokinin; Duodenum; Gastrins; Gastrointestinal Motility; Hormone Antagonists; Humans; Male; Muscarinic Antagonists; Pancreatic Polypeptide; Proglumide; Pyloric Antrum; Pylorus; Receptor, Cholecystokinin A; Receptors, Cholecystokinin | 1996 |
Physiological control of cholecystokinin release and pancreatic enzyme secretion by intraduodenal bile acids.
Topics: Adult; Bile Acids and Salts; Bilirubin; Cholecystokinin; Duodenum; Hormone Antagonists; Humans; Intestinal Secretions; Male; Pancreas; Pancreatic Polypeptide; Perfusion; Proglumide; Receptors, Cholecystokinin | 1996 |
Clinical evaluation and safety of loxiglumide (CCK-A receptor antagonist) in nonresectable pancreatic cancer patients. Italian Pancreatic Cancer Study Group.
Topics: Double-Blind Method; Female; Hormone Antagonists; Humans; Male; Middle Aged; Neoplasm Recurrence, Local; Neoplasm Staging; Pancreatic Neoplasms; Proglumide; Prospective Studies; Receptor, Cholecystokinin A; Receptors, Cholecystokinin; Safety; Survival Analysis | 1997 |
Cholecystokinin in transient lower oesophageal sphincter relaxation due to gastric distension in humans.
Topics: Adult; Cholecystokinin; Double-Blind Method; Esophagogastric Junction; Female; Gastroesophageal Reflux; Hormone Antagonists; Humans; Male; Manometry; Pressure; Proglumide; Receptors, Cholecystokinin; Stomach Diseases | 1997 |
Effect of cholecystokinin-A receptor blockade on lipid-induced gastric relaxation in humans.
Topics: Adult; Cross-Over Studies; Dietary Fats; Double-Blind Method; Fasting; Fat Emulsions, Intravenous; Female; Gastric Fundus; Hormone Antagonists; Humans; Injections, Intravenous; Instillation, Drug; Male; Muscle Relaxation; Muscle, Smooth; Pressure; Proglumide; Receptor, Cholecystokinin A; Receptors, Cholecystokinin; Stomach | 1997 |
Effects of a specific CCK-A antagonist, Loxiglumide, on postprandial mood and sleepiness.
Topics: Adult; Affect; Cross-Over Studies; Double-Blind Method; Hormone Antagonists; Humans; Male; Postprandial Period; Proglumide; Receptor, Cholecystokinin A; Receptors, Cholecystokinin; Sleep Stages | 1997 |
Role of cholecystokinin in the regulation of liquid gastric emptying and gastric motility in humans: studies with the CCK antagonist loxiglumide.
Topics: Adult; Cholecystokinin; Female; Gastric Emptying; Gastrointestinal Motility; Hormone Antagonists; Humans; Magnetic Resonance Imaging; Male; Proglumide; Receptors, Cholecystokinin; Single-Blind Method; Stomach | 1997 |
The role of cholecystokinin and the cholinergic system in intravenous amino acid-induced gallbladder emptying.
Topics: Adult; Amino Acids; Atropine; Cholecystokinin; Cholinergic Fibers; Gallbladder; Hormone Antagonists; Humans; Injections, Intravenous; Male; Muscarinic Antagonists; Proglumide; Ultrasonography | 1997 |
Involvement of cholecystokininA receptors in transient lower esophageal sphincter relaxations triggered by gastric distension.
Topics: Adult; Deglutition; Double-Blind Method; Esophagogastric Junction; Female; Gastroesophageal Reflux; Hormone Antagonists; Humans; Male; Manometry; Peristalsis; Proglumide; Receptor, Cholecystokinin A; Receptors, Cholecystokinin; Reflex; Stomach | 1998 |
Endogenous cholecystokinin in postprandial lower esophageal sphincter function and fundic tone in humans.
Topics: Adult; Cholecystokinin; Duodenum; Eating; Enteral Nutrition; Esophagogastric Junction; Fasting; Female; Gastric Fundus; Hormone Antagonists; Humans; Male; Manometry; Muscle Relaxation; Muscle Tonus; Proglumide; Receptor, Cholecystokinin A; Receptors, Cholecystokinin | 1998 |
Physiological role of cholecystokinin in gastroprotection in humans.
Topics: Adult; Cholecystokinin; Double-Blind Method; Duodenum; Ethanol; Gastric Mucosa; Gastroscopy; Hormone Antagonists; Humans; Injections, Intravenous; Male; Oleic Acid; Proglumide; Sincalide; Somatostatin; Stomach | 1998 |
Clinical evaluation of cholecystokinin-A- receptor antagonist (loxiglumide) for the treatment of acute pancreatitis. A preliminary clinical trial. Study Group of Loxiglumide in Japan.
Topics: Abdominal Pain; Acute Disease; Adult; Amylases; Dose-Response Relationship, Drug; Female; Hormone Antagonists; Humans; Injections, Intravenous; Male; Pancreatitis; Proglumide; Receptors, Cholecystokinin; Treatment Outcome | 1999 |
Inhibition of food intake in response to intestinal lipid is mediated by cholecystokinin in humans.
Topics: Adult; Cross-Over Studies; Dietary Fats; Double-Blind Method; Duodenum; Eating; Energy Intake; Hormone Antagonists; Humans; Infusions, Parenteral; Male; Proglumide; Receptor, Cholecystokinin A; Receptors, Cholecystokinin; Satiation | 1999 |
The role of long chain fatty acids in regulating food intake and cholecystokinin release in humans.
Topics: Adult; Cholecystokinin; Cross-Over Studies; Double-Blind Method; Duodenum; Eating; Energy Intake; Fatty Acids; Hormone Antagonists; Humans; Hunger; Male; Proglumide; Receptors, Cholecystokinin | 2000 |
Interaction between CCK and a preload on reduction of food intake is mediated by CCK-A receptors in humans.
Topics: Adult; Cholecystokinin; Cross-Over Studies; Double-Blind Method; Eating; Energy Intake; Humans; Hunger; Infusions, Intravenous; Male; Proglumide; Receptor, Cholecystokinin A; Receptors, Cholecystokinin; Satiety Response; Sincalide | 2000 |
Eradication of Helicobacter pylori restores the inhibitory effect of cholecystokinin on gastric motility in duodenal ulcer patients.
Topics: Adolescent; Adult; Analysis of Variance; Cholecystokinin; Duodenal Ulcer; Follow-Up Studies; Gastric Emptying; Gastric Mucosa; Gastrins; Gastroscopy; Helicobacter Infections; Helicobacter pylori; Hormone Antagonists; Humans; Injections, Intravenous; Male; Postprandial Period; Probability; Proglumide; Reference Values; Sensitivity and Specificity; Somatostatin; Sucralfate; Treatment Outcome | 2001 |
The effect of cholecystokinin antagonism on postprandial lower oesophageal sphincter function in asymptomatic volunteers and patients with reflux disease.
Topics: Adult; Aged; Cholecystokinin; Cross-Over Studies; Double-Blind Method; Esophagogastric Junction; Female; Gastroesophageal Reflux; Hormone Antagonists; Humans; Male; Middle Aged; Postprandial Period; Proglumide | 2001 |
Clinical evaluation of oral administration of a cholecystokinin-A receptor antagonist (loxiglumide) to patients with acute, painful attacks of chronic pancreatitis: a multicenter dose-response study in Japan.
Topics: Acute Disease; Administration, Oral; Adult; Amylases; Chronic Disease; Female; Hormone Antagonists; Humans; Lipase; Male; Middle Aged; Pain; Pancreatitis; Proglumide; Receptor, Cholecystokinin A; Receptors, Cholecystokinin; Treatment Outcome; Trypsin | 2002 |
Role of CCK(A) receptors in postprandial lower esophageal sphincter function in morbidly obese subjects.
Topics: Adult; Esophagogastric Junction; Hormone Antagonists; Humans; Manometry; Middle Aged; Obesity, Morbid; Postprandial Period; Proglumide; Receptor, Cholecystokinin A; Receptors, Cholecystokinin | 2002 |
CCK-1 receptor blockade for treatment of biliary colic: a pilot study.
Topics: Adolescent; Adult; Aged; Biliary Tract Diseases; Colic; Female; Humans; Male; Middle Aged; Pain Measurement; Pilot Projects; Proglumide; Receptors, Cholecystokinin | 2003 |
173 other study(ies) available for loxiglumide and proglumide
| Article | Year |
|---|---|
Role of endogenously released cholecystokinin in determining postprandial insulin levels in man: effects of loxiglumide, a specific cholecystokinin receptor antagonist.
Topics: Adult; Blood Glucose; Cholecystokinin; Gallbladder Emptying; Gastric Inhibitory Polypeptide; Humans; Insulin; Male; Pancreas; Proglumide; Receptors, Cholecystokinin | 1992 |
Direct contractile effect of motilin on isolated smooth muscle cells of guinea pig small intestine.
Topics: Animals; Atropine; Calcium; Cholecystokinin; Guinea Pigs; In Vitro Techniques; Intestine, Small; Male; Motilin; Muscle Contraction; Muscle, Smooth; Proglumide; Substance P | 1992 |
[Effects of cholecystokinin and its antagonists on the GI tract. Potent inhibition of gastrointestinal motility by loxiglumide].
Topics: Bile Acids and Salts; Cholecystokinin; Dose-Response Relationship, Drug; Gallbladder; Gastrointestinal Motility; Humans; Proglumide | 1992 |
Effect of loxiglumide and atropine on erythromycin-induced reduction in gallbladder volume in human subjects.
Topics: Adult; Atropine; Cholecystokinin; Erythromycin; Female; Gallbladder; Humans; Male; Pancreatic Polypeptide; Proglumide; Pulse; Ultrasonography | 1992 |
Role of cholecystokinin in mediating GRP-stimulated gastric, biliary and pancreatic functions in man.
Topics: Adult; Cholecystokinin; Gallbladder; Gastric Acid; Gastrin-Releasing Peptide; Gastrins; Gastrointestinal Hormones; Humans; Male; Pancreas; Peptides; Proglumide | 1992 |
[Effects of UFT and loxiglumide (CR1505) on liver metastasis of human pancreatic cancer cell line, KP-1 N in nude mice].
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Division; Cholecystokinin; Humans; Liver Neoplasms; Mice; Mice, Nude; Pancreatic Neoplasms; Proglumide; Tegafur; Tumor Cells, Cultured; Uracil | 1992 |
Combined dose-ratio analysis of cholecystokinin receptor antagonists, devazepide, lorglumide and loxiglumide in the guinea-pig gall bladder.
Topics: Analysis of Variance; Animals; Benzodiazepinones; Binding, Competitive; Biological Assay; Cholecystokinin; Devazepide; Dose-Response Relationship, Drug; Gallbladder; Guinea Pigs; Muscle, Smooth; Pentagastrin; Proglumide; Receptors, Cholecystokinin; Sincalide | 1992 |
[Effect of combined use of CR 1505 with UFT on tumor growth of transplanted pancreatic cancer in the Syrian golden hamster: preliminary report].
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Division; Cholecystokinin; Cricetinae; Drug Synergism; Mesocricetus; Neoplasm Transplantation; Pancreatic Neoplasms; Proglumide; Tegafur; Uracil | 1992 |
Intestinal microcirculatory changes during fat absorption and the effect of cholecystokinin inhibitor.
Topics: Animals; Blood Flow Velocity; Cholecystokinin; Dietary Fats; Erythrocytes; In Vitro Techniques; Intestinal Absorption; Intestinal Mucosa; Jejunum; Lymph; Male; Microcirculation; Muscle, Smooth; Muscle, Smooth, Vascular; Oleic Acid; Oleic Acids; Proglumide; Rats; Rats, Inbred Strains | 1992 |
Growth inhibition of human pancreatic cancer cells by cholecystokinin receptor antagonist in tissue culture and in nude mice.
Topics: Adenocarcinoma; Animals; Ceruletide; Cholecystokinin; Humans; In Vitro Techniques; Liver Neoplasms; Mice; Mice, Nude; Pancreatic Neoplasms; Proglumide; Tumor Cells, Cultured | 1992 |
Effects of cholecystokinin receptor blockade on circulating concentrations of glucose, insulin, C-peptide, and pancreatic polypeptide after various meals in healthy human volunteers.
Topics: Administration, Oral; Adult; Blood Glucose; C-Peptide; Cholecystokinin; Diet; Dose-Response Relationship, Drug; Glucose; Humans; Infusions, Intravenous; Insulin; Male; Pancreatic Polypeptide; Proglumide; Receptors, Cholecystokinin | 1992 |
Determination of plasma cholecystokinin (CCK) concentrations by bioassay and radioimmunoassay in man. A critical evaluation.
Topics: Adult; Animals; Biological Assay; Cholecystokinin; Eating; Evaluation Studies as Topic; Humans; Lipase; Male; Pancreas; Proglumide; Radioimmunoassay; Rats; Rats, Inbred Strains | 1992 |
Inhibitory effects of the cholecystokinin antagonist loxiglumide on pancreatic exocrine secretion and pancreatic growth in conscious rats.
Topics: Animals; Cholecystokinin; Male; Pancreas; Pancreatic Juice; Proglumide; Rats; Rats, Inbred Strains | 1992 |
Cholecystokinin contracts isolated human and monkey iris sphincters; a study with CCK receptor antagonists.
Topics: Aged; Aged, 80 and over; Animals; Cholecystokinin; Female; Humans; In Vitro Techniques; Iris; Macaca fascicularis; Male; Middle Aged; Muscle Contraction; Proglumide; Receptors, Cholecystokinin; Sincalide | 1992 |
Cephalic stimulation of gastrointestinal secretory and motor responses in humans.
Topics: Adult; Atropine; Brain; Cholecystokinin; Eating; Gastric Acid; Gastrins; Gastrointestinal Motility; Humans; Male; Pancreas; Pancreatic Polypeptide; Proglumide | 1992 |
A physiological role for cholecystokinin as a regulator of gastrin secretion.
Topics: Adult; Cholecystokinin; Food; Gastrin-Releasing Peptide; Gastrins; Humans; Male; Peptides; Proglumide | 1992 |
Interaction of the cholinergic system and cholecystokinin in the regulation of endogenous and exogenous stimulation of pancreatic secretion in humans.
Topics: Adult; Amylases; Atropine; Ceruletide; Cholecystokinin; Chymotrypsin; Food; Humans; Lipase; Male; Pancreas; Parasympathetic Nervous System; Proglumide; Trypsin | 1991 |
Effect of the specific cholecystokinin-receptor antagonist loxiglumide on bombesin stimulated pancreatic enzyme secretion in man.
Topics: Adult; Amylases; Bilirubin; Bombesin; Cholecystokinin; Duodenum; Female; Humans; Male; Pancreas; Proglumide; Receptors, Cholecystokinin | 1991 |
Opposite effects of cholestyramine and loxiglumide on gallbladder dynamics in humans.
Topics: Adult; Analysis of Variance; Cholestyramine Resin; Female; Food; Gallbladder; Gallbladder Emptying; Humans; Male; Proglumide; Receptors, Cholecystokinin; Reference Values; Time Factors; Ultrasonography | 1992 |
Influence of the CCK-antagonist loxiglumide on bile-induced experimental pancreatitis.
Topics: Animals; Male; Pancreatitis; Proglumide; Rats; Rats, Inbred Strains; Receptors, Cholecystokinin; Taurocholic Acid; Time Factors | 1991 |
Neuroendocrine regulation of growth hormone secretion in sheep. IV. Central and peripheral cholecystokinin.
Topics: Animals; Cholecystokinin; Growth Hormone; Immune Sera; Injections, Intravenous; Injections, Intraventricular; Male; Neurosecretory Systems; Proglumide; Sheep | 1991 |
[Effects of CR1505, a CCK antagonist, on pancreatic growth in hamsters].
Topics: Animals; Cholecystokinin; Cricetinae; Dose-Response Relationship, Drug; Male; Mesocricetus; Pancreas; Proglumide | 1991 |
CCK receptor antagonist loxiglumide alters uptake of CCK in perfused liver and pancreatic acini of the rat.
Topics: Animals; Ceruletide; Cholecystokinin; Liver; Male; Pancreas; Perfusion; Proglumide; Rats; Rats, Inbred Strains; Receptors, Cholecystokinin | 1991 |
Role of CCK in regulation of pancreaticobiliary functions and GI motility in humans: effects of loxiglumide.
Topics: Adult; Bilirubin; Cholecystokinin; Eating; Feces; Gallbladder; Gastrointestinal Motility; Humans; Lipase; Lipid Metabolism; Male; Muscle Contraction; Muscle, Smooth; Pancreas; Pancreatic Juice; Proglumide; Reference Values; Trypsin | 1991 |
Effects of CCK receptor blockade on intestinal motor activity in conscious dogs.
Topics: Animals; Ceruletide; Cholecystokinin; Digestion; Dogs; Eating; Female; Gastrointestinal Motility; Male; Muscle Contraction; Myoelectric Complex, Migrating; Neostigmine; Proglumide; Receptors, Cholecystokinin | 1991 |
Studies of three non-peptide cholecystokinin antagonists (devazepide, lorglumide and loxiglumide) in human isolated alimentary muscle and guinea-pig ileum.
Topics: Animals; Benzodiazepinones; Cholecystokinin; Devazepide; Digestive System; Digestive System Physiological Phenomena; Female; Guinea Pigs; Humans; Ileum; In Vitro Techniques; Male; Muscle Contraction; Proglumide; Receptors, Cholecystokinin; Sincalide | 1991 |
Effects of cholecystokinin-receptor blockade on pancreatic and biliary function in healthy volunteers.
Topics: Adult; Bilirubin; Cholecystokinin; Female; Gallbladder; Humans; Intestinal Absorption; Male; Pancreas; Pancreatic Juice; Proglumide; Receptors, Cholecystokinin | 1991 |
[Therapeutic perspectives in the irritable bowel syndrome].
Topics: Abdominal Pain; Antidiarrheals; Benzodiazepines; Cholecystokinin; Colonic Diseases, Functional; Constipation; Diarrhea; Female; Humans; Male; Proglumide | 1990 |
Effect of loxiglumide, a cholecystokinin antagonist, on pancreatic polypeptide release in humans.
Topics: Adult; Cholecystokinin; Duodenum; Eating; Female; Humans; Intubation, Gastrointestinal; Male; Pancreatic Polypeptide; Perfusion; Proglumide | 1990 |
Cholecystokinin is a regulator of intestinal phase-stimulated PP release.
Topics: Adult; Atropine; Ceruletide; Cholecystokinin; Humans; Infusions, Intravenous; Intestinal Mucosa; Male; Pancreatic Polypeptide; Proglumide | 1990 |
Effects of a cholecystokinin receptor antagonist on intestinal phase of pancreatic and biliary responses in man.
Topics: Adult; Bile Acids and Salts; Cholecystokinin; Food; Glutamine; Humans; Intestines; Male; Pancreas; Pancreatic Polypeptide; Proglumide; Receptors, Cholecystokinin | 1990 |
Effect of loxiglumide on gallbladder contractile response to cerulein and food in humans.
Topics: Adult; Ceruletide; Cholecystokinin; Dose-Response Relationship, Drug; Drug Interactions; Feeding Behavior; Gallbladder; Glutamine; Humans; Male; Muscle Contraction; Proglumide; Reference Values; Time Factors | 1990 |
Mechanism of inhibitory action of peptide YY on cholecystokinin-induced contractions of isolated dog ileum.
Topics: Animals; Cholecystokinin; Dogs; Female; Gallbladder; Glutamine; Ileum; Isometric Contraction; Male; Muscle Contraction; Peptide YY; Peptides; Proglumide; Sincalide | 1990 |
Cholecystokinin in the inhibition of gastric secretion and gastric emptying in humans.
Topics: Adult; Cholecystokinin; Dietary Fats; Gastric Acid; Gastric Emptying; Gastrins; Humans; Male; Pancreatic Polypeptide; Peptones; Proglumide; Receptors, Cholecystokinin | 1990 |
Effect of a new cholecystokinin receptor antagonist loxiglumide on acute pancreatitis in two experimental animal models.
Topics: Acute Disease; Animals; Ceruletide; Cholecystokinin; Disease Models, Animal; Glutamine; Male; Pancreatitis; Proglumide; Rats; Rats, Inbred Strains; Receptors, Cholecystokinin; Taurocholic Acid | 1990 |
Effect of loxiglumide (CR-1505) on bombesin- and meal-stimulated plasma cholecystokinin in man.
Topics: Adult; Bombesin; Cholecystokinin; Female; Food; Glutamine; Humans; Male; Proglumide; Receptors, Cholecystokinin | 1990 |
Fasting prevents acute pancreatitis induced by cerulein in rats.
Topics: Acute Disease; Animals; Ceruletide; Cholecystokinin; Fasting; Male; Pancreas; Pancreatitis; Proglumide; Rats; Rats, Inbred Strains; Secretin | 1990 |
Receptor type for cholecystokinin on isolated intestinal muscle cells of the guinea pig.
Topics: Animals; Cholecystokinin; Dose-Response Relationship, Drug; Gallbladder; Gastrins; Guinea Pigs; Hormones; Intestinal Mucosa; Intestines; Muscle, Smooth; Pancreas; Pentagastrin; Proglumide; Receptors, Cholecystokinin | 1990 |
Lorglumide and loxiglumide inhibit gastrin-stimulated DNA synthesis in a rat tumoral acinar pancreatic cell line (AR42J).
Topics: Animals; DNA, Neoplasm; Gastrins; Glutamine; Ornithine Decarboxylase; Pancreatic Neoplasms; Proglumide; Rats; Receptors, Cholecystokinin; Thymidine; Tumor Cells, Cultured | 1990 |
Comparison of loxiglumide, a cholecystokinin receptor antagonist, and atropine on hormonal and meal-stimulated pancreatic secretion in man.
Topics: Adult; Atropine; Bicarbonates; Cholecystokinin; Duodenum; Eating; Food, Formulated; Glutamine; Humans; Infusions, Intravenous; Pancreas; Proglumide; Receptors, Cholecystokinin; Secretin; Secretory Rate | 1990 |
Determination of loxiglumide in pharmaceutical preparations by using capillary zone electrophoresis.
Topics: Electrophoresis; Glutamine; Proglumide; Tablets | 1990 |
Comparative effects of CCK receptor antagonists on rat pancreatic secretion in vivo.
Topics: Amylases; Animals; Benzodiazepinones; Ceruletide; Cholecystokinin; Chymotrypsinogen; Devazepide; Dose-Response Relationship, Drug; Male; Pancreas; Proglumide; Proteins; Rats; Rats, Inbred Strains; Receptors, Cholecystokinin; Secretin | 1989 |
Loxiglumide. A new proglumide analog with potent cholecystokinin antagonistic activity in the rat pancreas.
Topics: Amylases; Animals; Binding, Competitive; Cholecystokinin; Dose-Response Relationship, Drug; Glutamine; Pancreas; Proglumide; Rats; Receptors, Cholecystokinin; Sincalide | 1989 |
[Inhibitory effect of a new proglumide derivative, loxiglumide, on CCK action in isolated rat pancreatic acini].
Topics: Amylases; Animals; Cholecystokinin; Glutamine; In Vitro Techniques; Male; Pancreas; Proglumide; Rats; Rats, Inbred Strains; Sincalide | 1989 |
Treatment of biliary colic with loxiglumide.
Topics: Biliary Tract Diseases; Cholecystokinin; Colic; Female; Glutamine; Humans; Male; Proglumide; Time Factors | 1989 |
Pharmacokinetics and tolerance of repeated oral doses of loxiglumide.
Topics: Adult; Biotransformation; Cholecystokinin; Female; Glutamine; Humans; Male; Patient Compliance; Proglumide | 1989 |
[Effect of CCK on the large intestine].
Topics: Animals; Cholecystokinin; Gastrointestinal Motility; Glutamine; Intestine, Large; Male; Muscle Contraction; Muscle, Smooth; Proglumide; Rats; Rats, Inbred Strains | 1989 |
Differential effects of atropine and a cholecystokinin receptor antagonist on pancreatic secretion.
Topics: Adult; Atropine; Cholecystokinin; Dose-Response Relationship, Drug; Esters; Feedback; Gabexate; Glutamine; Guanidines; Humans; Male; Pancreas; Peptide Hydrolases; Proglumide; Protease Inhibitors; Pulse; Reference Values | 1989 |
CCK receptor antagonism by loxiglumide and gall bladder contractions in response to cholecystokinin, sham feeding and ordinary feeding in man.
Topics: Adolescent; Adult; Cholecystokinin; Food; Gallbladder; Glutamine; Humans; Male; Muscle Contraction; Proglumide; Receptors, Cholecystokinin; Sincalide | 1989 |
The effect of loxiglumide (CR-1505) on basal and bombesin-stimulated gallbladder volume in man.
Topics: Adult; Bombesin; Cholecystokinin; Female; Gallbladder; Humans; Male; Muscle Contraction; Muscle, Smooth; Proglumide; Time Factors | 1989 |
Effect of CCK antagonists CR 1409 and CR 1505 on rat pancreatic exocrine secretion in vivo.
Topics: Animals; Caseins; Cholecystokinin; Male; Pancreas; Proglumide; Rats; Rats, Inbred Strains | 1989 |
Pharmacokinetics of loxiglumide after single intravenous or oral doses in man.
Topics: Administration, Oral; Adult; Cholecystokinin; Chromatography, High Pressure Liquid; Glutamine; Humans; Infusions, Intravenous; Injections, Intravenous; Proglumide | 1988 |
Anticholecystokinin activities of loxiglumide.
Topics: Anesthesia; Animals; Ceruletide; Cholecystokinin; Dogs; Female; Gallbladder; Gastrointestinal Motility; Glutamine; Guinea Pigs; In Vitro Techniques; Male; Mice; Pancreas; Proglumide; Rabbits; Rats; Rats, Inbred Strains; Species Specificity | 1987 |
Loxiglumide protects against experimental pancreatitis.
Topics: Animals; Ceruletide; Diet; Female; Glutamine; Male; Mice; Pancreatitis; Proglumide; Rats; Rats, Inbred Strains; Taurocholic Acid | 1987 |
Biological effects of a proglumide derivative as cholecystokinin antagonist in conscious dogs.
Topics: Animals; Cholecystokinin; Dogs; Dose-Response Relationship, Drug; Gastric Acid; Glutamine; Infusions, Intravenous; Pancreatic Juice; Pancreatic Polypeptide; Pentagastrin; Proglumide; Sincalide | 1987 |
Pharmacological characterisation of a new potent and specific nonpolypeptidic cholecystokinin antagonist.
Topics: Animals; Cerebral Cortex; Cholecystokinin; Female; Gallbladder; Glutamine; Guinea Pigs; Ileum; In Vitro Techniques; Male; Mice; Muscle, Smooth; Pancreas; Proglumide; Rats; Rats, Inbred Strains; Receptors, Cholecystokinin; Species Specificity | 1987 |
Cholecystokinin in the control of gastric acid secretion and gastrin release in response to a meal at low and high pH in healthy subjects and duodenal ulcer patients.
Topics: Adult; Case-Control Studies; Cholecystokinin; Duodenal Ulcer; Food; Gastric Acid; Gastrins; Hormone Antagonists; Humans; Hydrogen-Ion Concentration; Male; Premedication; Proglumide; Receptors, Cholecystokinin; Somatostatin; Time Factors | 1995 |
Eradication of Helicobacter pylori restores the inhibitory effect of cholecystokinin on postprandial gastrin release in duodenal ulcer patients.
Topics: Adult; Cholecystokinin; Duodenal Ulcer; Eating; Gastric Acid; Gastrins; Helicobacter Infections; Helicobacter pylori; Humans; Hydrogen-Ion Concentration; Male; Monitoring, Physiologic; Proglumide; Somatostatin | 1995 |
Loxiglumide, L-364,718 and L-365,260 prevent the inhibition of spontaneous acetylcholine release from the frontal cerebral cortex of freely moving rat peripherally administered with cholecystokinin-8S.
Topics: Acetylcholine; Animals; Benzodiazepinones; Cerebral Cortex; Cholecystokinin; Devazepide; Injections, Intraperitoneal; Injections, Subcutaneous; Male; Phenylurea Compounds; Proglumide; Rats; Rats, Wistar; Receptors, Cholecystokinin | 1995 |
CGRP(8-37) and CGRP(32-37) contract the iris sphincter in the rabbit eye: antagonism by spantide and GR82334.
Topics: Animals; Calcitonin Gene-Related Peptide; Female; Male; Miotics; Neurokinin-1 Receptor Antagonists; Peptide Fragments; Physalaemin; Proglumide; Rabbits; Receptors, Calcitonin Gene-Related Peptide; Receptors, Cholecystokinin; Receptors, Tachykinin; Substance P; Tetrodotoxin | 1993 |
Pharmacological profile of FK480, a novel cholecystokinin type-A receptor antagonist: comparison to loxiglumide.
Topics: Amylases; Animals; Benzodiazepinones; Female; Gastric Emptying; Guinea Pigs; Indoles; Male; Mice; Mice, Inbred ICR; Proglumide; Rats; Rats, Sprague-Dawley; Receptors, Cholecystokinin; Sincalide | 1994 |
Cholecystokinin in the hormonal stimulation of amino acid uptake and pancreatic enzyme secretion.
Topics: Adult; Amino Acids; Amylases; Bicarbonates; Ceruletide; Cholecystokinin; Gallbladder; Humans; Male; Pancreas; Pancreatic Polypeptide; Proglumide; Secretin | 1994 |
Mechanisms for pancreatic hypertrophy induced by long-term administration of bethanechol.
Topics: Amylases; Animals; Atropine; Bethanechol; Cholinergic Agonists; Cholinergic Antagonists; Drug Administration Schedule; Drug Interactions; Gastrins; Hypertrophy; Male; Organ Size; Pancreas; Pentagastrin; Proglumide; Rats; Rats, Wistar; Receptors, Cholecystokinin; Sincalide | 1994 |
Exogenous and endogenous cholecystokinin protects gastric mucosa against the damage caused by ethanol in rats.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Aspirin; Cholecystokinin; Dose-Response Relationship, Drug; Duodenum; Ethanol; Gastric Mucosa; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Proglumide; Rats; Rats, Wistar; Receptors, Cholecystokinin; Regional Blood Flow; Stomach Ulcer | 1995 |
Cholinergic stimulatory effect of intragastric administration of a prostaglandin E2 analogue on pancreatic exocrine secretion in conscious rats.
Topics: Amylases; Animals; Antibodies; Atropine; Cholecystokinin; Cyclic AMP; Enprostil; Injections, Intravenous; Kinetics; Male; Pancreas; Proglumide; Rats; Rats, Wistar; Secretin; Stomach; Vagotomy | 1995 |
Effect of the cholecystokinin receptor antagonist loxiglumide on pancreatic exocrine function in rats after acute pancreatitis.
Topics: Acute Disease; Amylases; Animals; DNA; Lipase; Male; Pancreas; Pancreatitis; Proglumide; Proteins; Rats; Rats, Wistar; Receptors, Cholecystokinin; Regeneration; Trypsin | 1995 |
Effect of a novel cholecystokinin receptor antagonist, FK480, administered intraduodenally, on pancreatic secretion in rats.
Topics: Amylases; Animals; Benzodiazepinones; Caseins; Duodenum; Indoles; Male; Pancreas; Pancreatic Juice; Proglumide; Rats; Rats, Wistar; Receptors, Cholecystokinin; Sincalide | 1995 |
Activation of trypsinogen in experimental models of acute pancreatitis in rats.
Topics: Acute Disease; alpha-Macroglobulins; Animals; Benzamidines; Ceruletide; Disease Models, Animal; Guanidines; Male; Oligopeptides; Pancreatitis; Proglumide; Protease Inhibitors; Rats; Rats, Wistar; Receptors, Cholecystokinin; Taurocholic Acid; Trypsin; Trypsinogen | 1995 |
Effects of CCK-receptor antagonist on colonic motor activity in dogs.
Topics: Animals; Ceruletide; Colon; Depression, Chemical; Dogs; Fasting; Female; Gastrointestinal Motility; Male; Neostigmine; Proglumide; Receptors, Cholecystokinin | 1995 |
Involvement of endogenous cholecystokinin in the development of acute pancreatitis induced by closed duodenal loop.
Topics: Acute Disease; Amylases; Animals; Cholecystokinin; Disease Models, Animal; Duodenum; Lipase; Male; Pancreas; Pancreatitis; Proglumide; Rats; Rats, Wistar | 1993 |
Effect of intrinsic CCK and CCK antagonist on pancreatic growth and pancreatic enzyme secretion in pancreaticobiliary diversion rats.
Topics: Amylases; Animals; Biliary Tract Surgical Procedures; Cholecystokinin; Hypertrophy; Lipase; Male; Pancreas; Proglumide; Rats; Rats, Wistar; Secretin; Time Factors; Trypsinogen | 1993 |
A cholecystokinin receptor antagonist, loxiglumide, stimulates biliary secretion in conscious rats.
Topics: Analysis of Variance; Animals; Benzodiazepinones; Bile; Bile Acids and Salts; Bile Ducts; Bilirubin; Cholecystokinin; Devazepide; Dose-Response Relationship, Drug; Injections, Subcutaneous; Male; Proglumide; Rats; Rats, Wistar; Receptors, Cholecystokinin | 1994 |
Regulation of pancreatic polypeptide release is mediated through M3 muscarinic receptors.
Topics: Animals; Atropine; Cholecystokinin; Dogs; Female; Gastric Acid; Male; Pancreatic Juice; Pancreatic Polypeptide; Parasympatholytics; Piperidines; Pirenzepine; Proglumide; Receptors, Muscarinic; Vagus Nerve | 1994 |
Negative feedback regulation of pancreatic exocrine secretion in guinea pigs.
Topics: Animals; Atropine; Cholecystokinin; Chymotrypsin; Feedback; Guinea Pigs; Male; Oleic Acid; Oleic Acids; Pancreas; Pancreatic Juice; Proglumide; Radioimmunoassay; Secretin; Trypsin | 1995 |
CCK-A antagonists: which and how.
Topics: Benzodiazepinones; Devazepide; Gallbladder; Humans; Muscle Contraction; Muscle, Smooth; Proglumide; Receptor, Cholecystokinin A; Receptors, Cholecystokinin; Stereoisomerism | 1995 |
Lack of effect of cholecystokinin receptor antagonist (CR1505) on recovery of experimental pancreatitis after pancreatic duct occlusion in rats.
Topics: Animals; Body Weight; Cholecystokinin; Duodenum; Eating; Intestinal Mucosa; Ligation; Male; Organ Size; Pancreatic Ducts; Pancreatitis; Proglumide; Proteins; Rats; Rats, Wistar; Receptors, Cholecystokinin; Regeneration | 1994 |
PD 135158, a CCKB/gastrin receptor antagonist, stimulates rat pancreatic enzyme secretion as a CCKA receptor agonist.
Topics: Animals; Anti-Anxiety Agents; Cholecystokinin; Drug Interactions; Indoles; Lipase; Meglumine; Pancreas; Proglumide; Rats; Sincalide | 1993 |
Cholecystokinin in the control of gastric acid secretion in humans.
Topics: Adult; Ceruletide; Cholecystokinin; Dose-Response Relationship, Drug; Gastric Acid; Gastrin-Releasing Peptide; Gastrins; Humans; Male; Peptides; Proglumide; Receptors, Cholecystokinin; Somatostatin | 1993 |
C-terminal calcitonin gene-related peptide fragments and vasopressin but not somatostatin-28 induce miosis in monkeys.
Topics: Analysis of Variance; Animals; Calcitonin Gene-Related Peptide; Dose-Response Relationship, Drug; Female; Macaca fascicularis; Male; Miosis; Peptide Fragments; Proglumide; Pupil; Receptors, Cholecystokinin; Somatostatin; Somatostatin-28; Tetrodotoxin; Vasopressins | 1993 |
Inhibitory action of CCK-OP on rat proximal colon.
Topics: Acetylcholine; Animals; Atropine; Colon; Fasting; Hexamethonium; Hexamethonium Compounds; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Proglumide; Rats; Receptors, Cholecystokinin; Sincalide | 1994 |
Effect of intraduodenal infusion of tocamphyl on pancreatic exocrine secretion and gastrointestinal hormone release in rats.
Topics: Analysis of Variance; Animals; Atropine; Bile; Camphor; Cholagogues and Choleretics; Cholecystokinin; Dose-Response Relationship, Drug; Drug Interactions; Ethanolamines; Gastrointestinal Hormones; Male; Pancreatic Juice; Proglumide; Radioimmunoassay; Rats; Rats, Wistar; Secretin; Sincalide | 1994 |
Effects of cholecystokinin receptor antagonist loxiglumide on rat exocrine pancreas.
Topics: Administration, Oral; Animals; DNA; Dose-Response Relationship, Drug; Injections, Subcutaneous; Male; Organ Size; Pancreas; Proglumide; Proteins; Rats; Rats, Wistar; Receptors, Cholecystokinin | 1994 |
Effect of protein derivatives on pancreatic secretion and release of secretin and CCK in rats.
Topics: Amino Acids; Animals; Cholecystokinin; Immune Sera; Male; Oligopeptides; Pancreas; Proglumide; Proteins; Rats; Rats, Wistar; Receptors, Cholecystokinin; Secretin; Solutions | 1994 |
Physiological role of cholecystokinin on gastric emptying and acid output in dogs.
Topics: Animals; Cholecystokinin; Dogs; Gastric Acid; Gastric Emptying; Gastrins; Proglumide; Somatostatin | 1994 |
Treatment with cholecystokinin receptor antagonist loxiglumide enhances insulin response to intravenous glucose stimulation in postpancreatitic rats.
Topics: Acute Disease; Animals; Ceruletide; Glucose; Injections, Intravenous; Injections, Subcutaneous; Insulin; Insulin Resistance; Insulin Secretion; Islets of Langerhans; Male; Pancreatitis; Proglumide; Rats; Rats, Wistar; Receptors, Cholecystokinin; Sincalide | 1994 |
Characterization of a new cholecystokinin receptor antagonist FK480 in in vitro isolated rat pancreatic acini.
Topics: Animals; Benzodiazepinones; Devazepide; In Vitro Techniques; Indoles; Male; Pancreas; Proglumide; Rats; Rats, Wistar; Receptors, Cholecystokinin; Sincalide | 1994 |
CCK-receptor antagonists proglumide and loxiglumide stimulate bile flow and biliary glutathione excretion.
Topics: Animals; Bile; Bile Acids and Salts; Cholagogues and Choleretics; Dose-Response Relationship, Drug; Glutathione; Infusions, Intravenous; Liver; Male; Proglumide; Rats; Rats, Sprague-Dawley; Receptors, Cholecystokinin | 1994 |
Effect of digested protein on pancreatic exocrine secretion and gut hormone release in the dog.
Topics: Animals; Bicarbonates; Cholecystokinin; Dogs; Female; Kinetics; Liver; Male; Pancreas; Pancreatic Juice; Proglumide; Proteins; Receptors, Cholecystokinin; Secretin | 1994 |
Effect of loxiglumide (CR 1505) on CCK-induced contractions and 3H-acetylcholine release from guinea-pig gallbladder.
Topics: Acetylcholine; Animals; Cholecystokinin; Female; Gallbladder; Guinea Pigs; In Vitro Techniques; Male; Muscle Contraction; Proglumide; Tritium | 1993 |
Influence of fatty acid absorption on bidirectional release of immunoglobulin A into intestinal lumen and intestinal lymph in rats.
Topics: Animals; Cholecystokinin; Fatty Acids; Immunoglobulin A, Secretory; Intestinal Absorption; Intestines; Lymph; Male; Micelles; Poloxalene; Proglumide; Rats; Rats, Wistar | 1993 |
Autocrine growth stimulation of human renal Wilms' tumour G401 cells by a gastrin-like peptide.
Topics: Benzamides; Benzodiazepinones; Cell Division; Devazepide; Gastrins; Humans; Indoles; Kidney Neoplasms; Meglumine; Phenylurea Compounds; Proglumide; Receptors, Cholecystokinin; Tumor Cells, Cultured; Wilms Tumor | 1994 |
Effects of dietary fat on postprandial gastrointestinal motility are inhibited by a cholecystokinin type A receptor antagonist.
Topics: Adult; Corn Oil; Dietary Fats; Duodenum; Eating; Female; Gastrointestinal Motility; Humans; Infusions, Intravenous; Male; Manometry; Muscle Contraction; Muscle, Smooth; Proglumide; Pyloric Antrum; Random Allocation; Receptors, Cholecystokinin | 1994 |
Comparison of the effects of the CCK-receptor antagonist loxiglumide and the M1-receptor antagonist telenzepine on the pancreatic protein response to intraduodenal tryptophan in dogs. First results.
Topics: Animals; Dogs; Duodenum; Female; Male; Pancreas; Pancreatic Juice; Parasympatholytics; Pirenzepine; Proglumide; Proteins; Receptors, Cholecystokinin; Secretin; Tryptophan | 1994 |
Role of CCK in the regulation of dynamic and tonic mechanical response of the human gastric fundus to lipids.
Topics: Adult; Double-Blind Method; Fat Emulsions, Intravenous; Female; Gastric Fundus; Humans; Infusions, Intravenous; Male; Muscle Tonus; Muscle, Smooth; Pressure; Proglumide; Random Allocation; Receptors, Cholecystokinin | 1994 |
Endogenous CCK in the control of gastric secretory response to meal in normal subjects and duodenal ulcer patients.
Topics: Adult; Cholecystokinin; Duodenal Ulcer; Eating; Gastric Acid; Gastric Mucosa; Humans; Hydrogen-Ion Concentration; Proglumide; Receptors, Cholecystokinin; Reference Values | 1994 |
Loxiglumide (CR1505), a cholecystokinin antagonist, specifically inhibits the growth of human pancreatic cancer lines xenografted into nude mice.
Topics: Animals; Cell Division; Chloroquine; Cholecystokinin; DNA; Esters; Gabexate; Guanidines; Humans; Mice; Mice, Inbred BALB C; Mice, Nude; Neoplasm Transplantation; Organ Culture Techniques; Pancreatic Neoplasms; Proglumide; Sincalide; Transplantation, Heterologous | 1993 |
Neuronal receptors for caerulein in gallbladder.
Topics: Acetylcholine; Animals; Ceruletide; Gallbladder; Guinea Pigs; Muscle Contraction; Neurons; Proglumide; Receptors, Cholecystokinin | 1993 |
Inhibitory effects of a cholecystokinin antagonist, loxiglumide (CR-1505), on the growth of freshly separated and xenografted human pancreatic cancer.
Topics: Animals; Carcinoma, Intraductal, Noninfiltrating; Cholecystokinin; DNA, Neoplasm; Dose-Response Relationship, Drug; Humans; Mice; Mice, Nude; Neoplasm Transplantation; Pancreatic Neoplasms; Proglumide; RNA, Neoplasm; Transplantation, Heterologous; Tumor Cells, Cultured | 1993 |
Effect of cholestyramine and cholecystokinin receptor antagonist CR1505 (loxiglumide) on lower esophageal sphincter pressure in man.
Topics: Adult; Aged; Cholecystokinin; Cholestyramine Resin; Esophagogastric Junction; Female; Humans; Male; Middle Aged; Pressure; Proglumide; Receptors, Cholecystokinin | 1993 |
Cholecystokinin does not delay gastric emptying of regular meals in healthy humans.
Topics: Cholecystokinin; Dose-Response Relationship, Drug; Gastric Emptying; Humans; Proglumide | 1993 |
Inhibitory effect of intraduodenal infusion of loxiglumide on pancreatic exocrine secretion.
Topics: Animals; Cholecystokinin; Dogs; Duodenum; Female; Infusions, Intravenous; Intubation, Gastrointestinal; Male; Pancreas; Proglumide; Proteins | 1993 |
Cholecystokinin in the control of gastric acid secretion in man.
Topics: Adult; Ceruletide; Cholecystokinin; Dose-Response Relationship, Drug; Food; Gastric Acid; Gastrin-Releasing Peptide; Gastrins; Humans; Hydrogen-Ion Concentration; Male; Pentagastrin; Peptides; Proglumide; Receptors, Cholecystokinin; Secretory Rate | 1993 |
Duration and potency of anticholecystokinin action of subcutaneous and oral loxiglumide on cerulein-stimulated pancreatic exocrine secretion.
Topics: Administration, Oral; Animals; Ceruletide; Cholecystokinin; Injections, Subcutaneous; Male; Pancreas; Proglumide; Rats; Rats, Wistar; Time Factors | 1993 |
Cholecystokinin in the regulation of gastric acid and endocrine pancreatic secretion in humans.
Topics: Adult; Cholecystokinin; Food; Gastric Acid; Gastrins; Humans; Hydrogen-Ion Concentration; Male; Monitoring, Physiologic; Pancreas; Pancreatic Hormones; Proglumide; Radioimmunoassay | 1993 |
[Effect of combined use of CR1505 with UFT for the tumor growth of the subcutaneously transplanted pancreatic cancer in the Syrian golden hamsters].
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cell Division; Cholecystokinin; Cricetinae; Mesocricetus; Neoplasm Transplantation; Nitrosamines; Pancreatic Neoplasms; Proglumide; Tegafur; Uracil | 1993 |
Cholecystokinin (CCK) in the amino acid uptake and enzyme protein secretion by the pancreas in humans.
Topics: Adult; Amino Acids; Ceruletide; Gallbladder; Hormone Antagonists; Humans; Male; Pancreas; Pancreatic Hormones; Proglumide; Receptor, Cholecystokinin A; Receptors, Cholecystokinin; Secretin | 1995 |
Effects of intraduodenal administration of a low dose of cholecystokinin (CCK) antagonist (CR-1505) on plasma CCK concentration, intestinal CCK content, and levels of CCK mRNA.
Topics: Animals; Base Sequence; Body Weight; Cholecystokinin; Drug Administration Routes; Gene Expression; Hormone Antagonists; Intestinal Mucosa; Male; Molecular Sequence Data; Pancreas; Proglumide; Radioimmunoassay; Rats; Rats, Sprague-Dawley; RNA, Messenger; Trypsin | 1995 |
Regulation of gene expression of pancreatic secretory trypsin inhibitor-61 and -56 by bile and pancreatic juice in rats.
Topics: Animals; Base Sequence; Bile; Biliopancreatic Diversion; Ceruletide; Cholecystokinin; Gastrointestinal Agents; Gene Expression; Hormone Antagonists; Infusions, Intravenous; Male; Molecular Sequence Data; Pancreas; Pancreatic Juice; Proglumide; Rats; Rats, Wistar; RNA, Messenger; Sincalide; Trypsin Inhibitor, Kazal Pancreatic | 1995 |
Cholecystokinin [corrected] octapeptide modulates dopamine release in rat striatum.
Topics: Animals; Anti-Ulcer Agents; Apomorphine; Dopamine; Dopamine Agonists; Electric Stimulation; Hormone Antagonists; Male; Neostriatum; Proglumide; Rats; Rats, Wistar; Receptors, Cholecystokinin; Sincalide; Tritium | 1995 |
Cholecystokinin-GABA interactions in rat striatum.
Topics: Animals; Calcium; Cholecystokinin; Corpus Striatum; Electric Stimulation; gamma-Aminobutyric Acid; Hormone Antagonists; Indoles; Male; Meglumine; Proglumide; Rats; Rats, Wistar; Receptors, Cholecystokinin; Sincalide; Tetrodotoxin; Tritium | 1995 |
Luminal cholecystokinin and gastrin cause gallbladder contraction.
Topics: Animals; Bile; Cholecystokinin; Female; Gallbladder; Gastrins; Guinea Pigs; Hormone Antagonists; In Vitro Techniques; Muscle Contraction; Pentagastrin; Proglumide; Receptors, Cholecystokinin; Sincalide | 1996 |
Duration of anti-cholecystokinin (CCK) action on the rat exocrine pancreas of new CCK receptor antagonist FK480 administered orally.
Topics: Administration, Oral; Animals; Benzodiazepinones; Hormone Antagonists; Indoles; Infusions, Intravenous; Male; Pancreas; Pancreatic Juice; Proglumide; Rats; Rats, Wistar; Receptors, Cholecystokinin | 1996 |
Effects of cholecystokinin and carbachol on membrane fluidity in pancreatic acini.
Topics: Animals; Bombesin; Carbachol; Cholecystokinin; Dose-Response Relationship, Drug; Hormone Antagonists; L-Lactate Dehydrogenase; Male; Membrane Fluidity; Pancreas; Pancreatitis; Phosphatidylcholines; Proglumide; Rats; Rats, Wistar; Secretin; Sincalide | 1996 |
Role of endogenous platelet-activating factor in the regulation of pancreatic blood flow during caerulein stimulation.
Topics: Animals; Ceruletide; Cholecystokinin; Gastrointestinal Agents; Hormone Antagonists; Laser-Doppler Flowmetry; Male; Pancreas; Platelet Activating Factor; Proglumide; Pyridinium Compounds; Rats; Rats, Wistar; Regional Blood Flow; Stimulation, Chemical; Time Factors | 1996 |
Pharmacological profile of TP-680, a new cholecystokininA receptor antagonist.
Topics: Amylases; Animals; Benzodiazepinones; Binding, Competitive; Cerebral Cortex; Cysteine; Devazepide; In Vitro Techniques; Intracellular Membranes; Male; Niacin; Pancreas; Proglumide; Rats; Rats, Wistar; Receptor, Cholecystokinin A; Receptors, Cholecystokinin; Sincalide | 1996 |
Effect of the selective CCKB receptor antagonist LY288513 on conditioned fear stress in rats.
Topics: Animals; Behavior, Animal; Conditioning, Operant; Fear; Hormone Antagonists; Male; Proglumide; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptors, Cholecystokinin; Stress, Physiological | 1996 |
Effect of dexloxiglumide and spiroglumide, two new CCK-receptor antagonists, on gastric emptying and secretion in the rat: evaluation of their receptor selectivity in vivo.
Topics: Animals; Dose-Response Relationship, Drug; Gastric Acid; Gastric Emptying; Hormone Antagonists; Keto Acids; Male; Pentagastrin; Pentanoic Acids; Proglumide; Rats; Rats, Sprague-Dawley; Receptors, Cholecystokinin; Sincalide; Spiro Compounds | 1996 |
Pharmacological profile of T-0632, a novel potent and selective CCKA receptor antagonist, in vitro.
Topics: Amylases; Animals; Benzodiazepinones; Binding, Competitive; Brain; Cell Membrane; Devazepide; Gallbladder; Guinea Pigs; Hormone Antagonists; In Vitro Techniques; Indoles; Male; Muscle Contraction; Muscle, Smooth; Pancreas; Proglumide; Protein Binding; Rabbits; Rats; Rats, Sprague-Dawley; Receptors, Cholecystokinin; Sincalide | 1996 |
Comparison of the effects of two cholecystokinin-receptor antagonists, loxiglumide and L-364,718, on the pancreatic secretory response to intraduodenal tryptophan in dogs.
Topics: Animals; Benzodiazepinones; Bicarbonates; Cholecystokinin; Devazepide; Dogs; Duodenum; Female; Male; Pancreas; Perfusion; Proglumide; Receptors, Cholecystokinin; Secretin; Sincalide; Tryptophan | 1996 |
Role of endogenous cholecystokinin in the regeneration of pancreatic tissue after acute hemorrhagic pancreatitis in rats.
Topics: Acute Disease; Animals; Cholecystokinin; Hemorrhage; Male; Pancreas; Pancreatitis; Proglumide; Rats; Rats, Sprague-Dawley; Receptors, Cholecystokinin; Regeneration | 1996 |
Ca2+ antagonists reveal a novel inhibitory effect of caerulein on guinea pig ileum.
Topics: Acetylcholine; Animals; Calcium Channel Blockers; Ceruletide; Dibutyryl Cyclic GMP; Electric Stimulation; Female; Gastrointestinal Agents; Guinea Pigs; Hormone Antagonists; Ileum; Male; Muscle Contraction; Muscle, Smooth; Proglumide | 1995 |
Effect of a cholecystokinin receptor antagonist (loxiglumide) on gallbladder contractile function in guinea pigs.
Topics: Animals; Ceruletide; Cholecystokinin; Depression, Chemical; Gallbladder; Gallbladder Emptying; Gastrointestinal Agents; Guinea Pigs; Hormone Antagonists; Male; Proglumide; Receptors, Cholecystokinin | 1996 |
Decrease in exploratory behavior in naturally occurring cholecystokinin (CCK)-A receptor gene knockout rats.
Topics: Animals; Behavior, Animal; Exploratory Behavior; Grooming; Hormone Antagonists; Male; Motor Activity; Mutation; Proglumide; Rats; Rats, Inbred Strains; Rats, Mutant Strains; Receptor, Cholecystokinin A; Receptors, Cholecystokinin; Reference Values | 1996 |
Pharmacological profile of T-0632, a novel potent and selective CCKA receptor antagonist, in vivo.
Topics: Animals; Benzodiazepinones; Ceruletide; Devazepide; Dogs; Female; Gastric Emptying; Indoles; Male; Pancreas; Pancreatitis; Pregnancy; Proglumide; Rats; Rats, Sprague-Dawley; Receptor, Cholecystokinin A; Receptors, Cholecystokinin; Sincalide | 1996 |
Comparison of the effects of the M1-receptor antagonist telenzepine and the CCK-receptor antagonist loxiglumide on the pancreatic secretory response to intraduodenal tryptophan in dogs.
Topics: Animals; Bicarbonates; Dogs; Duodenum; Female; Heart Rate; Male; Muscarinic Antagonists; Pancreas; Pirenzepine; Proglumide; Proteins; Receptors, Cholecystokinin; Receptors, Muscarinic; Secretin; Tryptophan | 1996 |
Cholecystokinin receptor antagonist, loxiglumide, inhibits invasiveness of human pancreatic cancer cell lines.
Topics: Blotting, Western; Cell Line; Collagenases; Dose-Response Relationship, Drug; Electrophoresis, Polyacrylamide Gel; Gelatin; Hormone Antagonists; Humans; Kinetics; Matrix Metalloproteinase 9; Neoplasm Invasiveness; Pancreatic Neoplasms; Proglumide; Sincalide; Tumor Cells, Cultured | 1996 |
Effect of gastrin-releasing peptide (GRP) on guinea pig gallbladder contraction in vitro.
Topics: Acetylcholine; Animals; Atropine; Bombesin; Dose-Response Relationship, Drug; Gallbladder; Gastrin-Releasing Peptide; Guinea Pigs; Hormone Antagonists; In Vitro Techniques; Male; Muscarinic Antagonists; Muscle Contraction; Muscle, Smooth; Peptides; Proglumide; Sincalide | 1995 |
Pancreatic fluid hypersecretion in rats after acute pancreatitis.
Topics: Acute Disease; Animals; Antibodies; Atropine; Bicarbonates; Cell Division; Ceruletide; Chlorides; Cholinergic Antagonists; Hormone Antagonists; Male; Pancreas; Pancreatic Juice; Pancreatitis; Proglumide; Proteins; Rats; Rats, Wistar; Receptors, Cholecystokinin; Secretin | 1997 |
Effect of T-0632, a cholecystokininA receptor antagonist, on experimental acute pancreatitis.
Topics: Acute Disease; Amylases; Animals; Ceruletide; Disease Models, Animal; Dogs; Esters; Female; Gabexate; Guanidines; Hormone Antagonists; Indoles; Ligation; Male; Pancreatic Ducts; Pancreatitis; Proglumide; Protease Inhibitors; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptor, Cholecystokinin A; Receptors, Cholecystokinin | 1997 |
Both free and complexed trypsin inhibitors stimulate pancreatic secretion and change duodenal enzyme levels.
Topics: Animals; Benzodiazepinones; Cholecystokinin; Devazepide; Duodenum; Enteral Nutrition; Epithelial Cells; Epithelium; Hormone Antagonists; Intestine, Small; Pancreas; Peptides; Plant Proteins; Proglumide; Rats; Receptor, Cholecystokinin A; Receptors, Cholecystokinin; Stimulation, Chemical; Trypsin Inhibitors | 1997 |
CCK-resistance in Zucker obese versus lean rats.
Topics: Amylases; Animals; Capsaicin; Cholecystokinin; Eating; Female; Injections, Subcutaneous; Male; Obesity; Proglumide; Rats; Rats, Zucker; Receptors, Cholecystokinin | 1997 |
Stimulative effects of saponin from kikyo-to, a Japanese herbal medicine, on pancreatic exocrine secretion of conscious rats.
Topics: Animals; Atropine; Cholecystokinin; Duodenum; Esters; Gabexate; Glycyrrhizic Acid; Guanidines; Japan; Male; Pancreas; Pancreatic Juice; Plant Extracts; Plant Roots; Plants, Medicinal; Proglumide; Rats; Rats, Wistar; Receptors, Cholecystokinin; Saponins; Triterpenes; Trypsin; Trypsin Inhibitors | 1997 |
Cholecystokinin antagonistic activities of loxiglumide.
Topics: Animals; Cholecystokinin; Gallbladder; Gallbladder Emptying; Gastric Emptying; Gastrointestinal Motility; Gastrointestinal Transit; Guinea Pigs; Hormone Antagonists; In Vitro Techniques; Injections, Intravenous; Male; Mice; Mice, Inbred ICR; Proglumide; Rabbits; Rats; Rats, Sprague-Dawley | 1997 |
Impairment of hepatic transport processes in perfused rat liver by the specific CCK receptor antagonist loxiglumide.
Topics: Animals; Bile; Biological Transport; Cholagogues and Choleretics; Gastrins; Hormone Antagonists; Indocyanine Green; Leukotriene D4; Liver; Male; Portal Vein; Proglumide; Rats; Rats, Wistar; Receptors, Cholecystokinin; Sincalide; Taurocholic Acid | 1997 |
Effect of chronic oral administration of the CCK receptor antagonist loxiglumide on exocrine and endocrine pancreas in normal rats.
Topics: Administration, Oral; Animals; Body Weight; DNA; Dose-Response Relationship, Drug; Hormone Antagonists; Insulin; Islets of Langerhans; Male; Organ Size; Pancreas; Proglumide; Proteins; Rats; Rats, Wistar; Receptors, Cholecystokinin | 1997 |
General pharmacological profile of the novel cholecystokinin-A antagonist loxiglumide.
Topics: Animals; Autonomic Nervous System; Behavior, Animal; Central Nervous System; Cholecystokinin; Digestive System; Dogs; Female; Guinea Pigs; Hemodynamics; Hormone Antagonists; In Vitro Techniques; Male; Mice; Mice, Inbred ICR; Mice, Inbred Strains; Proglumide; Rabbits; Rats; Rats, Sprague-Dawley; Rats, Wistar; Respiration | 1997 |
Long-term effects of CCK-agonist and -antagonist on food intake and body weight in Zucker lean and obese rats.
Topics: Animals; Body Weight; Ceruletide; Cholecystokinin; Drug Resistance; Eating; Female; Male; Obesity; Organ Size; Pancreas; Proglumide; Rats; Rats, Zucker; Receptor, Cholecystokinin A; Receptors, Cholecystokinin; Satiety Response | 1998 |
Elevation of feed intake in parasite-infected lambs by central administration of a cholecystokinin receptor antagonist.
Topics: Animals; Benzodiazepinones; Devazepide; Dose-Response Relationship, Drug; Eating; Female; Gastric Emptying; Hormone Antagonists; Injections, Intraventricular; Proglumide; Receptors, Cholecystokinin; Sheep; Sheep Diseases; Time Factors; Trichostrongylosis | 1998 |
CCK administration after CCK receptor blockade accelerates recovery from cerulein-induced acute pancreatitis in rats.
Topics: Acute Disease; Amylases; Animals; Ceruletide; Cholecystokinin; DNA; Hormone Antagonists; Lipase; Male; Organ Size; Pancreas; Pancreatitis; Proglumide; Rats; Rats, Wistar; Receptors, Cholecystokinin; Regeneration; Sincalide; Trypsin | 1998 |
Effects of loxiglumide on pancreatic exocrine secretion stimulated by cholecystokinin-8 in conscious dogs.
Topics: Amylases; Animals; Cholecystokinin; Dogs; Female; Hormone Antagonists; In Vitro Techniques; Pancreas; Pancreatic Juice; Proglumide; Proteins; Receptors, Cholecystokinin; Trypsin | 1998 |
Effects of loxiglumide on pancreatic exocrine secretion stimulated by meal in conscious dogs.
Topics: Amylases; Animals; Bicarbonates; Dogs; Female; Food-Drug Interactions; Hormone Antagonists; Male; Pancreas; Pancreatic Juice; Proglumide; Receptors, Cholecystokinin; Trypsin | 1998 |
Biochemical and pharmacological profiles of loxiglumide, a novel cholecystokinin-A receptor antagonist.
Topics: Animals; Cattle; Cerebral Cortex; Gallbladder; Gastric Mucosa; Guinea Pigs; Hormone Antagonists; Male; Pancreas; Proglumide; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Cholecystokinin; Tissue Distribution | 1998 |
Effects of loxiglumide on experimental acute pancreatitis in comparison with gabexate mesilate.
Topics: Acute Disease; Amylases; Animals; Ceruletide; Duodenum; Female; Gabexate; Hormone Antagonists; Injections, Intravenous; Male; Mice; Mice, Inbred ICR; Organ Size; Pancreas; Pancreatitis; Proglumide; Rats; Rats, Sprague-Dawley; Receptors, Cholecystokinin; Serine Proteinase Inhibitors | 1998 |
Gastric emptying and motility: assessment with MR imaging--preliminary observations.
Topics: Adult; Contrast Media; Female; Gastric Emptying; Gastrointestinal Motility; Humans; Magnetic Resonance Imaging; Male; Meglumine; Organometallic Compounds; Proglumide; Stomach | 1998 |
Pituitary adenylate cyclase-activating peptide stimulates rat pancreatic secretion via secretin and cholecystokinin releases.
Topics: Animals; Cholecystokinin; Hormone Antagonists; Immune Sera; Male; Neuropeptides; Pancreas; Pituitary Adenylate Cyclase-Activating Polypeptide; Proglumide; Rats; Rats, Sprague-Dawley; Secretin | 1998 |
Endogenous CCK inhibits colonic contractions in unrestrained conscious rats.
Topics: Animal Feed; Animals; Colon; Dose-Response Relationship, Drug; Duodenum; Eating; Fasting; Gastrointestinal Motility; Hormone Antagonists; Intubation, Gastrointestinal; Male; Muscle Contraction; Muscle, Smooth; Portal Vein; Proglumide; Radioimmunoassay; Rats; Rats, Wistar; Receptor, Cholecystokinin A; Receptors, Cholecystokinin; Reference Values; Sincalide; Telemetry; Transducers | 1997 |
Effect of medium- and long-chain triglycerides on lower esophageal sphincter pressure: role of CCK.
Topics: Adult; Cholecystokinin; Dietary Fats; Duodenum; Esophagogastric Junction; Female; Gallbladder; Hormone Antagonists; Humans; Infusions, Intravenous; Kinetics; Male; Pressure; Proglumide; Receptors, Cholecystokinin; Triglycerides; Ultrasonography | 1998 |
Endogenous cholecystokinin enhances postprandial gastroesophageal reflux in humans through extrasphincteric receptors.
Topics: Adult; Cholecystokinin; Cholestyramine Resin; Eating; Electric Stimulation; Esophagogastric Junction; Esophagus; Gallbladder; Gastroesophageal Reflux; Humans; Hydrogen-Ion Concentration; In Vitro Techniques; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; Proglumide; Receptor, Cholecystokinin A; Receptors, Cholecystokinin; Sincalide | 1998 |
[Behavioral and neurochemical study on the role of the brain cholecystokinin system in anxiety].
Topics: Animals; Anxiety; Biogenic Monoamines; Brain; Cholecystokinin; Disease Models, Animal; Hormone Antagonists; Male; Proglumide; Pyrazoles; Rats; Rats, Sprague-Dawley; Receptor, Cholecystokinin A; Receptor, Cholecystokinin B; Receptors, Cholecystokinin | 1998 |
Fatty acid chain length determines cholecystokinin secretion and effect on human gastric motility.
Topics: Adolescent; Adult; Cholecystokinin; Fatty Acids; Female; Gallbladder; Gastric Mucosa; Gastrointestinal Motility; Hormone Antagonists; Humans; Male; Middle Aged; Muscle Tonus; Proglumide; Pyloric Antrum; Radioimmunoassay; Receptor, Cholecystokinin A; Receptors, Cholecystokinin; Stomach; Structure-Activity Relationship; Ultrasonography | 1999 |
Involvement of endogenous cholecystokinin and somatostatin in gastroprotection induced by intraduodenal fat.
Topics: Animals; Capsaicin; Cholecystokinin; Denervation; Dinoprostone; Dopamine Agents; Enzyme Inhibitors; Gastric Acid; Gastric Mucosa; Hormone Antagonists; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oleic Acid; Pepsin A; Proglumide; Rats; Rats, Wistar; Receptor, Cholecystokinin A; Receptors, Cholecystokinin; Sincalide; Somatostatin; Stomach Ulcer; Vagotomy | 1998 |
Role of intestinal chemoreception in the induction of gastrointestinal sensations.
Topics: Adult; Anesthetics, Local; Catheterization; Chemoreceptor Cells; Duodenum; Female; Hormone Antagonists; Humans; Hunger; Intestinal Mucosa; Intestine, Small; Male; Middle Aged; Nausea; Pain; Proglumide; Receptor, Cholecystokinin A; Receptors, Cholecystokinin; Satiation; Sensation; Stomach; Surveys and Questionnaires | 1998 |
Therapeutic effects of loxiglumide on experimental acute pancreatitis using various models.
Topics: Animals; Ceruletide; Disease Models, Animal; Female; Hormone Antagonists; Male; Mice; Pancreatitis, Acute Necrotizing; Proglumide; Rats; Rats, Sprague-Dawley; Survival Analysis | 1999 |
Mechanism of cholecystokinin-A- receptor antagonist on human pancreatic exocrine secretion. Localization of CCK-A receptor in the human duodenum.
Topics: Autoradiography; Base Sequence; Blotting, Northern; Devazepide; Duodenum; Gene Expression; Humans; Molecular Sequence Data; Pancreas; Proglumide; Receptors, Cholecystokinin; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger | 1999 |
Pharmacologic profile of TS-941, a new benzodiazepine derivative cholecystokinin-receptor antagonist, in in vitro isolated rat pancreatic acini.
Topics: Amylases; Animals; Benzodiazepines; Binding, Competitive; Cell Membrane; Cell Survival; Cells, Cultured; Cerebral Cortex; Devazepide; Dose-Response Relationship, Drug; Hormone Antagonists; Male; Pancreas; Proglumide; Rats; Rats, Wistar; Receptors, Cholecystokinin; Sincalide | 1999 |
Acceleration of ulcer healing by cholecystokinin (CCK): role of CCK-A receptors, somatostatin, nitric oxide and sensory nerves.
Topics: Animals; Cholecystokinin; DNA Replication; Dopamine Agents; Esters; Gabexate; Gastric Mucosa; Gastrins; Guanidines; Hormone Antagonists; Male; Nitric Oxide; Nitric Oxide Synthase; Nitroarginine; Pancreatin; Proglumide; Protease Inhibitors; Rats; Rats, Wistar; Receptors, Cholecystokinin; Regional Blood Flow; RNA, Messenger; Sensory Receptor Cells; Sincalide; Somatostatin; Stomach; Stomach Ulcer | 1999 |
Pharmacological and molecular characterization of muscular cholecystokinin receptors in the human lower oesophageal sphincter.
Topics: Adult; Aged; Benzodiazepines; Benzodiazepinones; Esophagogastric Junction; Female; Gastric Emptying; Gastrins; Gastrointestinal Agents; Gene Expression; Hormone Antagonists; Humans; In Vitro Techniques; Indoleacetic Acids; Male; Middle Aged; Phenylurea Compounds; Proglumide; Receptors, Cholecystokinin; Restriction Mapping; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Sincalide; Thiazoles | 2000 |
Loxiglumide, a CCK-A receptor antagonist, stimulates calorie intake and hunger feelings in humans.
Topics: Adult; Cross-Over Studies; Double-Blind Method; Drinking Behavior; Energy Intake; Feeding Behavior; Hormone Antagonists; Humans; Hunger; Male; Proglumide; Random Allocation; Receptor, Cholecystokinin A; Receptors, Cholecystokinin; Reference Values; Satiation | 2001 |
Role of cholecystokinin in the intestinal phase of pancreatic circulation in dogs.
Topics: Animals; Cholecystokinin; Dogs; Female; Hemodynamics; Hormone Antagonists; Intestines; Male; Milk; Pancreas; Proglumide; Proteins; Receptor, Cholecystokinin A; Receptors, Cholecystokinin; Regional Blood Flow | 2001 |
Inhibitory effect of loxiglumide (CR 1505), a cholecystokinin receptor antagonist, on N-nitrosobis(2-oxopropyl) amine-induced biliary carcinogenesis in Syrian hamsters.
Topics: Adenocarcinoma, Papillary; Animals; Autoradiography; Biliary Tract Neoplasms; Carcinogens; Cholecystectomy, Laparoscopic; Cricetinae; Disease Models, Animal; Duodenostomy; Female; Hormone Antagonists; Mesocricetus; Nitrosamines; Proglumide; Radiography; Receptors, Cholecystokinin | 2002 |
Effect of cholecystokinin-A receptor blockade on postprandial insulinaemia and gastric emptying in humans.
Topics: Adult; Blood Glucose; Gallbladder Emptying; Gastric Emptying; Humans; Insulin; Male; Postprandial Period; Proglumide; Receptor, Cholecystokinin A; Receptors, Cholecystokinin; Statistics, Nonparametric | 2002 |
Effect of cholecystokinin1 receptor antagonist loxiglumide (CR1505) on basal pancreatic exocrine secretion in conscious rats.
Topics: Amylases; Animals; Hormone Antagonists; Infusions, Intravenous; Islets of Langerhans; Kinetics; Male; Pancreatic Juice; Proglumide; Proteins; Rats; Rats, Sprague-Dawley; Receptor, Cholecystokinin A; Receptors, Cholecystokinin; Wakefulness | 2003 |
Differential mechanism and site of action of CCK on the pancreatic secretion and growth in rats.
Topics: Afferent Pathways; Amylases; Animals; Capsaicin; Cholecystokinin; Duodenum; Eating; Lipase; Male; Organ Size; Pancreas; Proglumide; Rats; Rats, Wistar; Sincalide; Trypsin; Trypsinogen; Vagotomy; Vagus Nerve | 2003 |
Involvement of capsaicin-sensitive afferent nerves and cholecystokinin 2/gastrin receptors in gastroprotection and adaptation of gastric mucosa to Helicobacter pylori-lipopolysaccharide.
Topics: Adaptation, Biological; Animals; Aspirin; Blotting, Western; Capsaicin; Gastric Acid; Gastric Mucosa; Gastrins; Helicobacter pylori; Hormone Antagonists; Interleukin-1; Leptin; Lipopolysaccharides; Male; Neurons, Afferent; Proglumide; Protective Agents; Rats; Rats, Wistar; Receptor, Cholecystokinin B; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Stomach Diseases; Tumor Necrosis Factor-alpha | 2004 |
Sensitive SPE-HPLC method to determine a novel angiotensin-AT1 antagonist in biological samples.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Chromatography, High Pressure Liquid; Proglumide; Purines; Quinolines; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Sensitivity and Specificity | 2004 |
Long-term bile diversion enhances basal and duodenal oleate-stimulated pancreatic exocrine secretion in dogs.
Topics: Animals; Bicarbonates; Bile Ducts; Cholecystokinin; Dogs; Duodenum; Gastric Fistula; Hormone Antagonists; Humans; Oleic Acid; Pancreas; Pancreatic Fistula; Proglumide; Receptor, Cholecystokinin A; Time Factors; Urinary Bladder | 2004 |
The effects of an essential fatty acid compound and a cholecystokinin-8 antagonist on iron deficiency induced anorexia and learning deficits.
Topics: Animal Feed; Animals; Avoidance Learning; Cholecystokinin; Energy Intake; Hormone Antagonists; Iron Deficiencies; Islets of Langerhans; Linoleic Acid; Male; Motor Activity; Peptide Fragments; Proglumide; Rats; Rats, Long-Evans; Swimming; Weight Gain | 2004 |
Use of a hepta-Tyr antibiotic modified silica stationary phase for the enantiomeric resolution of D,L-loxiglumide by electrochromatography and nano-liquid chromatography.
Topics: Anti-Bacterial Agents; Chromatography, Liquid; Chromatography, Micellar Electrokinetic Capillary; Nanotechnology; Proglumide; Reproducibility of Results; Sensitivity and Specificity; Stereoisomerism | 2004 |
Effects of the cholecystokinin A receptor antagonist loxiglumide on the proliferation and cell cycle time of pancreatic acinar cells in rats.
Topics: Animals; Cell Cycle; Cell Division; Hormone Antagonists; Kinetics; Male; Pancreas; Proglumide; Rats; Rats, Wistar; Receptor, Cholecystokinin B | 2006 |
Anthranilic acid based CCK1 receptor antagonists and CCK-8 have a common step in their "receptor desmodynamic processes".
Topics: Animals; Binding, Competitive; Biological Assay; Humans; Indoles; Ligands; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Structure; ortho-Aminobenzoates; Pancreas; Proglumide; Protein Conformation; Rats; Receptor, Cholecystokinin A; Sincalide; Spectrometry, Fluorescence; Structure-Activity Relationship | 2006 |
Stimulatory effect of N-methyltyramine, a congener of beer, on pancreatic secretion in conscious rats.
Topics: Amylases; Animals; Atropine; Beer; Benzodiazepines; Gastrins; Infusions, Intravenous; Injections; Male; Omeprazole; Pancreas; Pancreatic Juice; Proglumide; Proton Pump Inhibitors; Rats; Rats, Sprague-Dawley; Rats, Wistar; Receptor, Cholecystokinin A; Receptor, Cholecystokinin B; Solutions; Stomach; Tyramine | 2010 |
The effects on diet, anastomotic type, and loxiglumide on gastric emptying following gastrojejunostomy.
Topics: Anastomosis, Surgical; Animals; Cholecystokinin; Disease Models, Animal; Enteral Nutrition; Female; Gastric Bypass; Gastric Emptying; Hormone Antagonists; Jejunum; Male; Proglumide; Rats; Rats, Wistar; Stomach | 2009 |
Effect of endogenous cholecystokinin on the course of acute pancreatitis in rats.
Topics: Administration, Oral; Animals; Biomarkers; Bombesin; Cell Proliferation; Cholecystokinin; Disease Models, Animal; DNA Replication; Esters; Gabexate; Guanidines; Hormone Antagonists; Insulin Resistance; Male; Pancreas; Pancreatic Function Tests; Pancreatitis; Proglumide; Rats, Wistar; Receptor, Cholecystokinin A; Recovery of Function; Taurocholic Acid; Time Factors | 2015 |