lovastatin and fti 277
lovastatin has been researched along with fti 277 in 12 studies
Research
Studies (12)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (50.00) | 18.2507 |
| 2000's | 6 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Hamilton, AD; McGuire, TF; Qian, Y; Sebti, SM; Vogt, A | 2 |
| Hamilton, AD; Qian, Y; Sebti, SM; Sun, J; Vogt, A | 1 |
| Blaskovich, MA; Davies, P; Hamilton, AD; Johnson, BA; Pitt, B; Qian, Y; Sebti, SM; Stark, WW; Vasudevan, A | 1 |
| Bifulco, M; Di Matola, T; Fenzi, G; Laezza, C; Rossi, G; Vitale, M | 1 |
| Bailey, R; Hamilton, AD; Harlan, JM; Kovach, NL; Liu, L; Moesner, P; Sebti, SM | 1 |
| Dimitroulakos, J; Minden, MD; Penn, LZ; Tan, MM; Wong, WW; Xia, Z | 1 |
| Bannerman, DD; Hamilton, AD; Harlan, JM; Li, X; Liu, L; Sebti, SM; Tupper, JC; Winn, RK | 1 |
| Hohl, RJ; Holstein, SA; Wohlford-Lenane, CL | 1 |
| Efuet, ET; Keyomarsi, K | 1 |
| Broers, JL; Hennekam, RC; Kamps, M; Kuijpers, HJ; Marcelis, CL; Merckx, D; Ramaekers, FC; Smeets, HJ; Steijlen, PM; van den Wijngaard, A; van Steensel, MA; Verstraeten, VL; Zinn-Justin, S | 1 |
| Beck, JF; Bumbul, B; Sonnemann, J | 1 |
Other Studies
12 other study(ies) available for lovastatin and fti 277
| Article | Year |
|---|---|
Platelet-derived growth factor receptor tyrosine phosphorylation requires protein geranylgeranylation but not farnesylation.
Topics: 3T3 Cells; Alkyl and Aryl Transferases; Animals; Calcium-Calmodulin-Dependent Protein Kinases; Diterpenes; Enzyme Inhibitors; Farnesol; Farnesyltranstransferase; Kinetics; Lovastatin; Methionine; Mice; Phosphorylation; Phosphotyrosine; Protein Prenylation; Receptors, Platelet-Derived Growth Factor; Recombinant Proteins; Structure-Activity Relationship; Transfection; Transferases | 1996 |
Protein geranylgeranylation, not farnesylation, is required for the G1 to S phase transition in mouse fibroblasts.
Topics: Actins; Alkyl and Aryl Transferases; Animals; Benzamides; Cell Cycle; Cell Division; Cell Transformation, Neoplastic; Cells, Cultured; Cytoskeleton; Diterpenes; DNA; Enzyme Inhibitors; Farnesol; Fibroblasts; G1 Phase; Genes, ras; GTP-Binding Proteins; Lovastatin; Methionine; Mevalonic Acid; Mice; Protein Prenylation; Protein Serine-Threonine Kinases; Proto-Oncogene Proteins; Proto-Oncogene Proteins c-raf; rap GTP-Binding Proteins; ras Proteins; Resting Phase, Cell Cycle; S Phase; Transferases | 1996 |
The geranylgeranyltransferase-I inhibitor GGTI-298 arrests human tumor cells in G0/G1 and induces p21(WAF1/CIP1/SDI1) in a p53-independent manner.
Topics: Alkyl and Aryl Transferases; Benzamides; Breast Neoplasms; Cell Cycle; Cells, Cultured; Cyclin-Dependent Kinase Inhibitor p21; Cyclins; Enzyme Inhibitors; Female; Fibrosarcoma; G1 Phase; Head and Neck Neoplasms; Humans; Lovastatin; Methionine; Oligopeptides; Pancreatic Neoplasms; Protein Prenylation; Resting Phase, Cell Cycle; Tumor Suppressor Protein p53; Urinary Bladder Neoplasms | 1997 |
Inhibiting geranylgeranylation blocks growth and promotes apoptosis in pulmonary vascular smooth muscle cells.
Topics: Alkyl and Aryl Transferases; Animals; Apoptosis; Benzamides; Cell Division; Cells, Cultured; Enzyme Inhibitors; Farnesyltranstransferase; Flow Cytometry; GTP-Binding Proteins; Kinetics; Lovastatin; Methionine; Microcirculation; Muscle, Smooth, Vascular; Protein Prenylation; Pulmonary Artery; rap GTP-Binding Proteins; ras Proteins; Rats; Transcription Factors | 1998 |
Prenyltransferase inhibitors induce apoptosis in proliferating thyroid cells through a p53-independent CrmA-sensitive, and caspase-3-like protease-dependent mechanism.
Topics: Apoptosis; Benzamides; Caspases; Cell Division; Cell Line; Cysteine Proteinase Inhibitors; Dimethylallyltranstransferase; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Lovastatin; Methionine; Serpins; Thyroid Gland; Tumor Suppressor Protein p53; Viral Proteins | 1999 |
Integrin-dependent leukocyte adhesion involves geranylgeranylated protein(s).
Topics: Benzamides; Cell Adhesion; Diterpenes; Fibronectins; Humans; Integrins; Jurkat Cells; Leukocytes; Lovastatin; Methionine; Mitogen-Activated Protein Kinases; Phosphatidylinositol 3-Kinases; Tetradecanoylphorbol Acetate; U937 Cells | 1999 |
Blocking protein geranylgeranylation is essential for lovastatin-induced apoptosis of human acute myeloid leukemia cells.
Topics: Acute Disease; Apoptosis; Benzamides; Deoxyuracil Nucleotides; Fluorescein-5-isothiocyanate; Humans; Hydroxymethylglutaryl CoA Reductases; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Leukemia, Myeloid; Lovastatin; Methionine; Mevalonic Acid; Polyisoprenyl Phosphates; Protein Prenylation; Sesquiterpenes; Tumor Cells, Cultured | 2001 |
Inhibition of protein geranylgeranylation and RhoA/RhoA kinase pathway induces apoptosis in human endothelial cells.
Topics: Apoptosis; Benzamides; Caspase 3; Caspases; Cell Death; Cells, Cultured; Diterpenes; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Intracellular Signaling Peptides and Proteins; Lovastatin; Methionine; Polyisoprenyl Phosphates; Protein Prenylation; Protein Serine-Threonine Kinases; rho-Associated Kinases; rhoA GTP-Binding Protein; Umbilical Veins | 2002 |
Isoprenoids influence expression of Ras and Ras-related proteins.
Topics: Antineoplastic Agents; Blotting, Northern; Blotting, Western; Cycloheximide; Enzyme Inhibitors; Farnesyl-Diphosphate Farnesyltransferase; Humans; K562 Cells; Leucine; Lovastatin; Methionine; Mevalonic Acid; Polyisoprenyl Phosphates; Protein Biosynthesis; Protein Processing, Post-Translational; Protein Synthesis Inhibitors; rap1 GTP-Binding Proteins; ras Proteins; rhoA GTP-Binding Protein; rhoB GTP-Binding Protein; RNA, Messenger; Sesquiterpenes; Time Factors; Transcription, Genetic; Up-Regulation | 2002 |
Farnesyl and geranylgeranyl transferase inhibitors induce G1 arrest by targeting the proteasome.
Topics: Antineoplastic Agents; Benzamides; Breast Neoplasms; Cyclin-Dependent Kinase Inhibitor p21; Enzyme Inhibitors; G1 Phase; Humans; Lactic Acid; Lovastatin; Methionine; Proteasome Endopeptidase Complex; Protein Prenylation; rap1 GTP-Binding Proteins; ras Proteins; Tumor Cells, Cultured; Up-Regulation | 2006 |
Compound heterozygosity for mutations in LMNA causes a progeria syndrome without prelamin A accumulation.
Topics: Adult; Bone and Bones; Cell Survival; Cells, Cultured; Child, Preschool; Female; Fibroblasts; Heterozygote; Humans; Imaging, Three-Dimensional; Immunohistochemistry; Lamin Type A; Lovastatin; Male; Methionine; Models, Molecular; Mutation; Nuclear Proteins; Progeria; Protein Precursors; Protein Prenylation; Radiography | 2006 |
Synergistic activity of the histone deacetylase inhibitor suberoylanilide hydroxamic acid and the bisphosphonate zoledronic acid against prostate cancer cells in vitro.
Topics: Antineoplastic Agents; Benzamides; Cell Death; Cell Line, Tumor; Diphosphonates; Drug Screening Assays, Antitumor; Drug Synergism; Histone Deacetylase Inhibitors; Humans; Hydroxamic Acids; Imidazoles; Lovastatin; Male; Methionine; Mitochondria; Prostatic Neoplasms; Vorinostat; Zoledronic Acid | 2007 |