losartan-potassium has been researched along with ukrain* in 1 studies
1 other study(ies) available for losartan-potassium and ukrain
| Article | Year |
|---|---|
Effects of Ukrain on the activities of DNA-nicking enzymes.
We studied the effects of Ukrain, a novel antitumor drug, on the activities of calcium, magnesium-dependent endonuclease (CME) and manganese-dependent endonuclease (MnDE) in rat liver nuclei, the activity of topoisomerase I assessed by pUC19 plasmid relaxation and CME activity in the nuclei of lymphocytes from colon cancer patients. Ukrain was found to exert a dose-dependent inhibiting effect on both CME and MnDE, similar to that exerted by erythropoietin, which was used as a reference preparation. Both Ukrain and erythropoietin also caused dose-dependent inhibition of topoisomerase I activity. The influence of Ukrain on CME activity in the nuclei of the lymphocytes of colon cancer patients was differential, depending on treatment efficacy. The results suggest that DNA-nicking enzymes may be a target of Ukrain and may mediate its antitumor effects. Topics: Alkaloids; Animals; Antineoplastic Agents, Phytogenic; Berberine Alkaloids; Cell Nucleus; DNA Topoisomerases, Type I; Endodeoxyribonucleases; Erythropoietin; Liver; Male; Phenanthridines; Rats; Recombinant Proteins | 2000 |