losartan-potassium and parthenolide

losartan-potassium has been researched along with parthenolide* in 1 studies

Other Studies

1 other study(ies) available for losartan-potassium and parthenolide

ArticleYear
Effect of carbamylated erythropoietin on major histocompatibility complex expression and neural differentiation of human neural stem cells.
    Journal of neuroimmunology, 2010, Apr-15, Volume: 221, Issue:1-2

    The expression of major histocompatibility complex (MHC) on human neural stem cells (hNSCs) is tightly related to the fate of these cells in transplantation, therefore strategies to relieve rejection and promote graft survival are necessary to be applied. This study investigated the effect of carbamylated erythropoietin (CEPO) on MHC expression and differentiation of hNSCs with or without IFN-gamma incubation. Results showed that low levels of MHC molecules were expressed on hNSCs and increased by IFN-gamma. CEPO enhanced MHC-I antigens in both proliferative and differentiated hNSCs, but decreased MHC-II antigens in differentiated hNSCs and those cells exposed to IFN-gamma. Furthermore, CEPO promoted neural differentiation of hNSCs and outgrowth of neurites. Western blot analysis revealed activation of Stat3, Stat5 and Akt during these processes. These results suggest that CEPO may have immunoregulatory function in hNSCs besides its neuroprotection.

    Topics: Androstadienes; Anti-Inflammatory Agents, Non-Steroidal; Cell Differentiation; Cells, Cultured; Cytokines; Embryonic Stem Cells; Epidermal Growth Factor; Erythropoietin; Fetus; Fibroblast Growth Factor 2; Flow Cytometry; Gene Expression Regulation, Developmental; Histocompatibility Antigens; Humans; Immunosuppressive Agents; Nerve Tissue Proteins; Neurites; Neurons; Sesquiterpenes; Wortmannin

2010