losartan-potassium and dimazine

losartan-potassium has been researched along with dimazine* in 1 studies

Other Studies

1 other study(ies) available for losartan-potassium and dimazine

Article	Year
Effects of prostaglandin E2 on the micronucleus formation in mouse bone marrow cells by various mutagens. Mutation research, 1994, Dec-01, Volume: 311, Issue:2 The effects of prostaglandin E2 (PGE2), as a trigger of erythroid progenitor cells into the cell cycle, were studied on the induction of micronuclei by various mutagens; with mitomicin C (MMC) the optimal protocol was established. PGE2 itself did not induce any micronuclei in this experiment. The highest frequency of micronuclei and dose-response relationship between PGE2 doses and micronucleus frequency were observed 30 h after injection of MMC to mice administered PGE2 24 h previously. Sensitization by PGE2 pretreatment was also found for other mutagens, such as vincristine, 5-fluorouracil, benzo[a]pyrene, 1,1-dimethylhydrazine and 2-naphthylamine. These results support the hypothesis that accelerating the erythropoiesis increases the frequency of micronuclei induced by mutagens. Topics: 2-Naphthylamine; Animals; Benzo(a)pyrene; Blood Cell Count; Bone Marrow; Bone Marrow Cells; Dimethylhydrazines; Dinoprostone; Dose-Response Relationship, Drug; Drug Synergism; Erythroblasts; Erythropoiesis; Erythropoietin; Fluorouracil; Male; Mice; Mice, Inbred BALB C; Micronucleus Tests; Mitomycin; Mutagens; Time Factors; Vincristine	1994

Article

Year

Effects of prostaglandin E2 on the micronucleus formation in mouse bone marrow cells by various mutagens.

Mutation research, 1994, Dec-01, Volume: 311, Issue:2

The effects of prostaglandin E2 (PGE2), as a trigger of erythroid progenitor cells into the cell cycle, were studied on the induction of micronuclei by various mutagens; with mitomicin C (MMC) the optimal protocol was established. PGE2 itself did not induce any micronuclei in this experiment. The highest frequency of micronuclei and dose-response relationship between PGE2 doses and micronucleus frequency were observed 30 h after injection of MMC to mice administered PGE2 24 h previously. Sensitization by PGE2 pretreatment was also found for other mutagens, such as vincristine, 5-fluorouracil, benzo[a]pyrene, 1,1-dimethylhydrazine and 2-naphthylamine. These results support the hypothesis that accelerating the erythropoiesis increases the frequency of micronuclei induced by mutagens.

Topics: 2-Naphthylamine; Animals; Benzo(a)pyrene; Blood Cell Count; Bone Marrow; Bone Marrow Cells; Dimethylhydrazines; Dinoprostone; Dose-Response Relationship, Drug; Drug Synergism; Erythroblasts; Erythropoiesis; Erythropoietin; Fluorouracil; Male; Mice; Mice, Inbred BALB C; Micronucleus Tests; Mitomycin; Mutagens; Time Factors; Vincristine

1994