losartan-potassium has been researched along with 3-hydroxykynurenine* in 1 studies
1 other study(ies) available for losartan-potassium and 3-hydroxykynurenine
| Article | Year |
|---|---|
Mechanism of inhibitory effect of 3-hydroxykynurenine on erythropoiesis in patients with renal insufficiency.
Increase of 3-hydroxykynurenine (3-HKYN) concentration was observed in plasma patients with chronic renal insufficiency (CRI). These changes positively correlated with the concentration of creatinine, but negatively correlated with haematological parameters: haematocrit, haemoglobin and red blood cells count. The changes were accompanied by a slight decrease of the concentration of erythropoietin (EPO) in plasma of patients with CRI. The "in vitro" study in the conditions of hypoxia showed that 3-HKYN inhibited the release of EPO from HepG2 cells to the culture base. In conclusion, the erythropoiesis in CRI could be attributed to the influence of 3-HKYN on EPO synthesis. Thus, we propose that 3-HKYN can be an uraemic of toxin partially responsible for anaemia patients with CRI. Topics: Adult; Aged; Anemia; Case-Control Studies; Cell Line; Erythropoiesis; Erythropoietin; Female; Humans; In Vitro Techniques; Kidney Failure, Chronic; Kynurenine; Male; Middle Aged | 2003 |