losartan-potassium and 15-hydroxy-5-8-11-13-eicosatetraenoic-acid

losartan-potassium has been researched along with 15-hydroxy-5-8-11-13-eicosatetraenoic-acid* in 2 studies

Other Studies

2 other study(ies) available for losartan-potassium and 15-hydroxy-5-8-11-13-eicosatetraenoic-acid

Article	Year
Effects of lipoxygenase metabolites of arachidonic acid on the growth of human blood CD34(+) progenitors. Blood cells, molecules & diseases, 2000, Volume: 26, Issue:5 The influence of lipoxygenase metabolites of arachidonic acid on proliferation and differentiation of CD34(+) cells was studied. Their effects on the CFU-GM and BFU-E progenitors were investigated by culture of CD34(+) cells in liquid or semisolid medium. Only 12-HETE (1 microM) stimulated the [(3)H]thymidine as well as BrdU incorporation and increased the number of cell divisions (PKH2 tracking). Addition of 12-HETE and 15-HETE but not of LXA(4), LXB(4), LTB(4), and LTC(4) to liquid cultures of CD34(+) cells for 3 and 8 days reduced in a time-dependent manner the number of CFU-GM and BFU-E. Both HETEs also increased the percentage of glycophorin A(+) cells while they reduced the percentage of CD34(-)/CD33(+) cells after 3 and 5 days of liquid cultures. These results show that HETE treatment stimulates proliferation and accelerates the differentiation of CD34(+) cells, mostly toward the erythroid lineage. Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Antigens, CD34; Antigens, Differentiation; Arachidonic Acids; Cell Count; Cell Division; Colony-Forming Units Assay; Culture Media; Dose-Response Relationship, Drug; Erythroid Precursor Cells; Erythropoietin; Hematopoietic Stem Cells; Humans; Hydroxyeicosatetraenoic Acids; Leukotriene B4; Lipoxins; Lipoxygenase; Methylcellulose; Solutions; Thymidine; Time Factors	2000
The action of erythropoietin is mediated by lipoxygenase metabolites in murine fetal liver cells. Biochemical and biophysical research communications, 1987, Aug-31, Volume: 147, Issue:1 Erythroid progenitor cells synthesize 12-hydroxyeicosatetraenoic acid (12-HETE) and 15-hydroxyeicosatetraenoic acid (15-HETE) when stimulated by erythropoietin (Ep). Maximal stimulation of 12-HETE production occurred at one hour, whereas 15-HETE activity remained constant in response to Ep for 24 hours. Lipoxygenase-selective inhibitors of arachidonic acid metabolism blocked HETE production and Ep-stimulated growth and differentiation of erythroid progenitor cell-derived colonies (CFU-E). On the other hand, specific inhibitors of cyclooxygenase (aspirin and meclofenamate) did not significantly inhibit Ep-induced erythroid colony formation. It is hypothesized that the stimulation of HETE production from arachidonic acid (AA) is an essential step in the mechanism of action of Ep. Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Butylated Hydroxyanisole; Erythropoiesis; Erythropoietin; Hydroxyeicosatetraenoic Acids; Liver; Masoprocol; Meclofenamic Acid; Mice; Phosphatidylinositols; Pyrazoles	1987

Article

Year

Effects of lipoxygenase metabolites of arachidonic acid on the growth of human blood CD34(+) progenitors.

Blood cells, molecules & diseases, 2000, Volume: 26, Issue:5

The influence of lipoxygenase metabolites of arachidonic acid on proliferation and differentiation of CD34(+) cells was studied. Their effects on the CFU-GM and BFU-E progenitors were investigated by culture of CD34(+) cells in liquid or semisolid medium. Only 12-HETE (1 microM) stimulated the [(3)H]thymidine as well as BrdU incorporation and increased the number of cell divisions (PKH2 tracking). Addition of 12-HETE and 15-HETE but not of LXA(4), LXB(4), LTB(4), and LTC(4) to liquid cultures of CD34(+) cells for 3 and 8 days reduced in a time-dependent manner the number of CFU-GM and BFU-E. Both HETEs also increased the percentage of glycophorin A(+) cells while they reduced the percentage of CD34(-)/CD33(+) cells after 3 and 5 days of liquid cultures. These results show that HETE treatment stimulates proliferation and accelerates the differentiation of CD34(+) cells, mostly toward the erythroid lineage.

Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; Antigens, CD34; Antigens, Differentiation; Arachidonic Acids; Cell Count; Cell Division; Colony-Forming Units Assay; Culture Media; Dose-Response Relationship, Drug; Erythroid Precursor Cells; Erythropoietin; Hematopoietic Stem Cells; Humans; Hydroxyeicosatetraenoic Acids; Leukotriene B4; Lipoxins; Lipoxygenase; Methylcellulose; Solutions; Thymidine; Time Factors

2000

The action of erythropoietin is mediated by lipoxygenase metabolites in murine fetal liver cells.

Biochemical and biophysical research communications, 1987, Aug-31, Volume: 147, Issue:1

Erythroid progenitor cells synthesize 12-hydroxyeicosatetraenoic acid (12-HETE) and 15-hydroxyeicosatetraenoic acid (15-HETE) when stimulated by erythropoietin (Ep). Maximal stimulation of 12-HETE production occurred at one hour, whereas 15-HETE activity remained constant in response to Ep for 24 hours. Lipoxygenase-selective inhibitors of arachidonic acid metabolism blocked HETE production and Ep-stimulated growth and differentiation of erythroid progenitor cell-derived colonies (CFU-E). On the other hand, specific inhibitors of cyclooxygenase (aspirin and meclofenamate) did not significantly inhibit Ep-induced erythroid colony formation. It is hypothesized that the stimulation of HETE production from arachidonic acid (AA) is an essential step in the mechanism of action of Ep.

Topics: 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; 4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; Animals; Arachidonic Acid; Arachidonic Acids; Aspirin; Butylated Hydroxyanisole; Erythropoiesis; Erythropoietin; Hydroxyeicosatetraenoic Acids; Liver; Masoprocol; Meclofenamic Acid; Mice; Phosphatidylinositols; Pyrazoles

1987