losartan and saralasin

losartan has been researched along with saralasin in 75 studies

Research

Studies (75)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	58 (77.33)	18.2507
2000's	14 (18.67)	29.6817
2010's	3 (4.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Assens, JL; Bernhart, CA; Clément, J; Ferrari, BP; Haudricourt, F; Muneaux, CF; Muneaux, YA; Perreaut, PM; Taillades, JE; Vignal, MA	1
Åqvist, J; Gutiérrez-de-Terán, H; Hallberg, A; Sallander, J; Wallinder, C	1
Akabane, S; Imanishi, M; Kawamura, M; Kuramochi, M; Matsushima, Y; Omae, T	1
Andries, M; Denef, C; Robberecht, W	2
Fregly, MJ; Rowland, NE	1
Bogdal, Y; Bottari, SP; Deschepper, CF; Obermüller, N; Zahs, KR	1
Bjork, FA; Hodges, JC; Keiser, JA; Taylor, DG	1
Blantz, RC; De Nicola, L; Gabbai, FB	1
Christ, DD; Duncia, JV; Pierce, SK; Reilly, TM; Timmermans, PB	1
Byrd, EW; Carr, BR; Rainey, WE; Sinnokrot, RA	1
Bühlmayer, P; Criscione, L; de Gasparo, M; Herold, P; Kamber, B; Ostermayer, F; Thomann, H; Whitebread, S	1
Bottari, SP; Culman, J; de Gasparo, M; Gohlke, P; Obermüller, N; Unger, T	1
Hajj-ali, AF; Zimmerman, BG	1
Fontoura, BM; Maack, T; Nussenzveig, DR; Timmermans, PB	1
Gackenheimer, SL; Gehlert, DR; Schober, DA	2
Hart, SD; Timmermans, PB; Wong, PC	1
Ferrario, CM; Khosla, MC; Trachte, GJ	1
Chang, RS; Lotti, VJ	1
Andrews, CW; Cowan, CL; Norman, MH; Smith, HD; Steffen, RP; Tang, FL	1
Kunihara, M; Kushida, H; Morita, O	1
Catt, KJ; Ji, H; Sandberg, K; Zhang, Y; Zheng, W	1
Bornkessel, B	1
Ahn, DK; Kim, HJ; Lee, WJ; Park, JS; Park, YY; Yang, EK	1
Hanss, BG; Lewy, JE; Vari, RC	1
Adler-Graschinsky, E; Enero, MA; Gironacci, MM; Peña, C	1
Bihoreau, C; Clauser, E; Conchon, S; Corvol, P; Monnot, C; Sirieix, ME	1
Ardaillou, R; Bizet, T; Chansel, D; Levy, B; Pham, P; Vandermeersch, S	1
Heemskerk, FM; Michels, KM; Saavedra, JM	1
Brown, JA; Cobb, CS	1
Brunner, HR; Burnier, M; Nussberger, J; Waeber, B	1
Bensoussan, M; Mitchell, T; Reilly, T; Ronco, PM; Timmermans, PB; Verroust, PJ	1
Ardaillou, R; Chansel, D; Pham, P; Vandermeersch, S	1
Castillo, G; Esteban, S; Orce, G	1
Eberhardt, RT; Frishman, WH; Kang, PM; Kevak, RM	1
Armstrong, DL; Denny, JB; Polan-Curtain, JL; Wayner, MJ	1
Abassi, ZA; Golomb, E; Keiser, HR; Klein, H	1
Barnes, JC; Clark, SA; Marshall, FH; Michel, AD	1
Dagenais, P; Escher, E	1
Clyne, CD; MacDonald, S; Nicol, MR; Walker, SW; Williams, BC	1
Endoh, M; Ishihata, A	1
Cervoni, P; Crandall, DL; Feliciano, L; Herzlinger, HE; Saunders, BD; Zolotor, RC	1
Brunner, HR; Nussberger, J; Waeber, B	1
Barber, PC; Barnes, JM; Barnes, NM; Steward, LJ	1
Baubonis, W; Benfield, P; Chiu, AT; Dunscomb, JH; McCall, DE; Sauer, B	1
Dudley, DT; Summerfelt, RM	1
Perrone, MH; Scheuer, DA	1
Betteridge, LJ; Hughes, AD; Patel, MK; Schachter, M	1
Stebbins, CL; Symons, JD	1
Benhaïm, A; Féral, C; Leymarie, P	1
Kawaguchi, H; Kitabatake, A	1
Diaz, RJ; Wilson, GJ	1
Chen, X; Fogo, A; Ichikawa, I; Inagami, T; Matsusaka, T; Niimura, F; Nishimura, H; Okubo, S; Tsuchida, S; Utsunomiya, H	1
Barbera, F; Diamond, S; Gibson, RE; Herblin, WF; Timmermans, P	1
Guimarães, S; Moura, D; Paiva, MQ	1
Georgiev, V; Georgieva, D	1
Henrion, D; Heymes, C; Lévy, BI; Loufrani, L; Matrougui, K	1
de Arruda Camargo, LA; Saad, WA	1
Albrecht, D; Bader, M; Von Bohlen und Halbach, O; Walther, T	1
Albertin, G; Malendowicz, LK; Markowska, A; Mazzocchi, G; Nussdorfer, GG	1
Gardi, J; Hajdu, I; Krueger, JM; Laczi, F; Obál, F	1
Boegehold, MA; Nurkiewicz, TR	1
Burnier, M	1
Calaghan, SC; White, E	1
Breno, MC; Picarelli, ZP; Porto, CS	1
Bica, RB; Caruso-Neves, C; Correa, JS; Lara, LS; Lopes, AG; Marques-Fernandes, MF; Sena, SL	1
Badzyńska, B; Dobrowolski, L; Grzelec-Mojzesowicz, M; Sadowski, J	1
Camargo, LA; Saad, WA	1
Alova, L; Georgiev, V; Stancheva, S; Velkova, M	1
Hayashi, K; Iwamoto, K; Kizawa, Y; Koike, K; Kusama, T; Murakami, H; Ohsawa, M; Ohuchi, N; Sano, M; Taniguchi, Y	1
Beirão, PS; dos Santos, RA; Moreira, TH; Rodrigues, AL; Santos Cruz, J	1
Fernandes, R; Ferreira, R; Gonçalves, PB; Moraes, JF; Oliveira, JF	1
Brailoiu, E; Brailoiu, GC; Deliu, E; Motoc, D; Tica, AA	1
Brigadirova, AA; Bukatina, TM; Spasov, AA; Yakovlev, DS	1

Reviews

5 review(s) available for losartan and saralasin

Article	Year
[Angiotensin II receptor antagonists]. Medizinische Monatsschrift fur Pharmazeuten, 1995, Volume: 18, Issue:6 Topics: Amino Acid Sequence; Angiotensin II; Angiotensin Receptor Antagonists; Antihypertensive Agents; Biphenyl Compounds; Hemodynamics; Humans; Hypertension; Imidazoles; Losartan; Molecular Sequence Data; Pyridines; Receptors, Angiotensin; Renin-Angiotensin System; Saralasin; Tetrazoles	1995
Angiotensin II antagonists. Clinical and experimental hypertension (New York, N.Y. : 1993), 1993, Volume: 15, Issue:6 Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Humans; Hypertension; Imidazoles; Losartan; Reference Values; Renin-Angiotensin System; Saralasin; Tetrazoles	1993
Angiotensin II receptor blockade: an innovative approach to cardiovascular pharmacotherapy. Journal of clinical pharmacology, 1993, Volume: 33, Issue:11 Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Cardiovascular Diseases; Heart Failure; Homeostasis; Humans; Hypertension; Imidazoles; Losartan; Receptors, Angiotensin; Renin-Angiotensin System; Saralasin; Tetrazoles	1993
Angiotensin antagonists. Advances in nephrology from the Necker Hospital, 1993, Volume: 22 Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Humans; Hypertension; Imidazoles; Kidney; Losartan; Receptors, Angiotensin; Saralasin; Tetrazoles	1993
Angiotensin II type 1 receptor blockers. Circulation, 2001, Feb-13, Volume: 103, Issue:6 Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Benzimidazoles; Binding, Competitive; Biphenyl Compounds; Blood Pressure; Drug Design; Humans; Irbesartan; Losartan; Peptidyl-Dipeptidase A; Protein Binding; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Renin-Angiotensin System; Saralasin; Tetrazoles; Valine; Valsartan	2001

Other Studies

70 other study(ies) available for losartan and saralasin

Article	Year
A new series of imidazolones: highly specific and potent nonpeptide AT1 angiotensin II receptor antagonists. Journal of medicinal chemistry, 1993, Oct-29, Volume: 36, Issue:22 Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Female; Imidazoles; In Vitro Techniques; Irbesartan; Macaca fascicularis; Male; Rabbits; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Sensitivity and Specificity; Structure-Activity Relationship; Tetrazoles	1993
Structural determinants of subtype selectivity and functional activity of angiotensin II receptors. Bioorganic & medicinal chemistry letters, 2016, Feb-15, Volume: 26, Issue:4 Topics: Amino Acid Sequence; Angiotensin II Type 1 Receptor Blockers; Binding Sites; Ligands; Molecular Docking Simulation; Protein Binding; Protein Structure, Tertiary; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Sequence Alignment	2016
Angiotensin II does not increase renal prostaglandin E2 in response to pressure reduction. Kidney international, 1992, Volume: 42, Issue:2 Topics: Angiotensin II; Animals; Biphenyl Compounds; Blood Pressure; Dinoprostone; Dogs; Female; Imidazoles; Infusions, Intra-Arterial; Kidney; Losartan; Male; Renal Circulation; Renin; Saralasin; Tetrazoles	1992
Stimulation of prolactin secretion from rat pituitary by luteinizing hormone-releasing hormone: evidence against mediation by angiotensin II acting through a (Sar1-Ala8)-angiotensin II-sensitive receptor. Neuroendocrinology, 1992, Volume: 56, Issue:2 Topics: 1-Sarcosine-8-Isoleucine Angiotensin II; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensinogen; Animals; Biphenyl Compounds; Captopril; Cells, Cultured; Female; Gonadotropin-Releasing Hormone; Imidazoles; Losartan; Male; Pituitary Gland; Prolactin; Rats; Rats, Wistar; Receptors, Angiotensin; Saralasin; Tetrazoles	1992
Effect of losartan potassium and deoxycorticosterone acetate on tail skin temperature response to acute administration of angiotensin II. Pharmacology, biochemistry, and behavior, 1992, Volume: 43, Issue:1 Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Body Temperature; Desoxycorticosterone; Imidazoles; Losartan; Male; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Saralasin; Skin Temperature; Tail; Tetrazoles	1992
Angiotensin II is retained in gonadotrophs of pituitary cell aggregates cultured in serum-free medium but does not mimic the effects of exogenous angiotensins and luteinizing-hormone-releasing hormone on growth hormone release. Neuroendocrinology, 1992, Volume: 56, Issue:4 Topics: Angiotensin II; Angiotensins; Animals; Biphenyl Compounds; Cells, Cultured; Chromatography, High Pressure Liquid; Culture Media, Serum-Free; Female; Gonadotropin-Releasing Hormone; Growth Hormone; Imidazoles; Immunohistochemistry; Losartan; Pituitary Gland, Anterior; Radioimmunoassay; Rats; Rats, Wistar; Saralasin; Tetrazoles	1992
Characterization and distribution of angiotensin II binding sites in fetal and neonatal astrocytes from different rat brain regions. Brain research, 1992, Jul-10, Volume: 585, Issue:1-2 Topics: Angiotensin II; Animals; Animals, Newborn; Astrocytes; Binding Sites; Binding, Competitive; Biphenyl Compounds; Brain; Cells, Cultured; Fetus; Imidazoles; Losartan; Oligopeptides; Rats; Saralasin; Tetrazoles; Tissue Distribution	1992
Renal hemodynamic and excretory responses to PD 123319 and losartan, nonpeptide AT1 and AT2 subtype-specific angiotensin II ligands. The Journal of pharmacology and experimental therapeutics, 1992, Volume: 262, Issue:3 Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Dogs; Female; Glomerular Filtration Rate; Hemodynamics; Imidazoles; Kidney; Losartan; Male; Pyridines; Renal Circulation; Saralasin; Tetrazoles	1992
Nitric oxide and angiotensin II. Glomerular and tubular interaction in the rat. The Journal of clinical investigation, 1992, Volume: 89, Issue:4 Topics: Angiotensin II; Animals; Arginine; Biphenyl Compounds; Glomerular Filtration Rate; Glycine; Imidazoles; Kidney Glomerulus; Kidney Tubules; Losartan; Male; Nitric Oxide; omega-N-Methylarginine; Rats; Rats, Inbred Strains; Saralasin; Tetrazoles	1992
Monoclonal antibodies to the nonpeptide angiotensin II receptor antagonist, losartan. European journal of pharmacology, 1992, Jun-05, Volume: 226, Issue:2 Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antibodies, Monoclonal; Antibody Specificity; Biphenyl Compounds; Cross Reactions; Enzyme-Linked Immunosorbent Assay; Imidazoles; Losartan; Mice; Mice, Inbred BALB C; Pyridines; Saralasin; Structure-Activity Relationship; Tetrazoles	1992
Angiotensin-II activation of cAMP and corticosterone production in bovine adrenocortical cells: effects of nonpeptide angiotensin-II antagonists. Molecular and cellular endocrinology, 1991, Volume: 81, Issue:1-3 Topics: Adrenal Cortex; Angiotensin I; Angiotensin II; Angiotensin III; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biphenyl Compounds; Cattle; Corticosterone; Cyclic AMP; Imidazoles; Losartan; Pyridines; Saralasin; Tetrazoles	1991
Binding characteristics and vascular effects of various angiotensin II antagonists. Journal of cardiovascular pharmacology, 1990, Volume: 16 Suppl 4 Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensins; Animals; Aorta; Biphenyl Compounds; Dose-Response Relationship, Drug; Female; Humans; Imidazoles; In Vitro Techniques; Ligands; Losartan; Muscle, Smooth, Vascular; Oligopeptides; Rabbits; Rats; Receptors, Angiotensin; Saralasin; Uterus	1990
Distribution of angiotensin II receptor subtypes in rat brain nuclei. Neuroscience letters, 1991, Oct-28, Volume: 132, Issue:1 Topics: Angiotensin II; Animals; Binding, Competitive; Biphenyl Compounds; Brain; Brain Stem; Hypothalamus; Imidazoles; Iodine Radioisotopes; Losartan; Male; Mesencephalon; Oligopeptides; Organ Specificity; Radioligand Assay; Rats; Rats, Inbred Strains; Receptors, Angiotensin; Saralasin; Tetrazoles	1991
Kinin contribution to renal vasodilator effect of captopril in rabbit. Hypertension (Dallas, Tex. : 1979), 1991, Volume: 17, Issue:4 Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Blood Pressure; Bradykinin; Captopril; Imidazoles; Kidney; Losartan; Rabbits; Receptors, Bradykinin; Receptors, Neurotransmitter; Renal Circulation; Saralasin; Tetrazoles; Vasodilation	1991
DuP 753 is a potent nonpeptide antagonist of angiotensin II receptors in isolated perfused rat kidney and cultured renal cells. American journal of hypertension, 1991, Volume: 4, Issue:4 Pt 2 Topics: Angiotensin Receptor Antagonists; Animals; Binding, Competitive; Cells, Cultured; Imidazoles; In Vitro Techniques; Kidney; Losartan; Male; Perfusion; Rats; Rats, Inbred Strains; Saralasin; Tetrazoles	1991
Angiotensin II receptor subtypes in rat brain: dithiothreitol inhibits ligand binding to AII-1 and enhances binding to AII-2. Brain research, 1991, Apr-12, Volume: 546, Issue:1 Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Autoradiography; Brain Chemistry; Dithiothreitol; Imidazoles; In Vitro Techniques; Iodine Radioisotopes; Losartan; Male; Pyridines; Rats; Rats, Inbred Strains; Receptors, Angiotensin; Saralasin; Tetrazoles	1991
Autoradiographic localization of subtypes of angiotensin II antagonist binding in the rat brain. Neuroscience, 1991, Volume: 44, Issue:2 Topics: Angiotensin II; Animals; Autoradiography; Binding Sites; Biphenyl Compounds; Brain; Imidazoles; Losartan; Male; Pyridines; Rats; Rats, Inbred Strains; Saralasin; Tetrazoles; Tissue Distribution	1991
Effect of angiotensin II antagonism on canine renal sympathetic nerve function. Hypertension (Dallas, Tex. : 1979), 1991, Volume: 17, Issue:6 Pt 2 Topics: Angiotensin II; Animals; Blood Pressure; Captopril; Dogs; Electric Stimulation; Female; Imidazoles; Kidney; Losartan; Male; Norepinephrine; Pyridines; Saralasin; Sympathetic Nervous System; Tetrazoles; Vascular Resistance; Vasoconstriction	1991
Selective blockade of angiotensin responses in the rabbit isolated vas deferens by angiotensin receptor antagonists. The Journal of pharmacology and experimental therapeutics, 1990, Volume: 255, Issue:3 Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Imidazoles; Losartan; Male; Prostaglandins E; Rabbits; Receptors, Angiotensin; Saralasin; Tetrazoles; Vas Deferens	1990
Two distinct angiotensin II receptor binding sites in rat adrenal revealed by new selective nonpeptide ligands. Molecular pharmacology, 1990, Volume: 37, Issue:3 Topics: Adrenal Glands; Aldosterone; Angiotensin II; Angiotensin III; Angiotensin Receptor Antagonists; Animals; Azoles; Binding, Competitive; Biphenyl Compounds; Cell Membrane; Dithiothreitol; Imidazoles; In Vitro Techniques; Ligands; Losartan; Pyridines; Rats; Receptors, Angiotensin; Saralasin	1990
4-(Heteroarylthio)-2-biphenylyltetrazoles as nonpeptide angiotensin II antagonists. Journal of medicinal chemistry, 1995, Nov-10, Volume: 38, Issue:23 Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Aorta, Abdominal; Binding, Competitive; Biphenyl Compounds; Imidazoles; Losartan; Male; Models, Molecular; Muscle Contraction; Naphthyridines; Quinolines; Rabbits; Radioligand Assay; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Saralasin; Structure-Activity Relationship; Sulfides; Tetrazoles	1995
Effects of U-97018 on pressor responses to intracerebroventricularly administered angiotensin II in conscious normotensive rats. Journal of cardiovascular pharmacology, 1995, Volume: 25, Issue:6 Topics: Administration, Oral; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Disease Models, Animal; Dose-Response Relationship, Drug; Hypertension; Imidazoles; Injections, Intravenous; Injections, Intraventricular; Losartan; Male; Pyridazines; Pyridines; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley; Saralasin; Tetrazoles	1995
Genetic transfer of a nonpeptide antagonist binding site to a previously unresponsive angiotensin receptor. Proceedings of the National Academy of Sciences of the United States of America, 1995, Sep-26, Volume: 92, Issue:20 Topics: Amino Acid Sequence; Amphibians; Animals; Antihypertensive Agents; Binding Sites; Binding, Competitive; Biphenyl Compounds; Cell Line; Chlorocebus aethiops; DNA Mutational Analysis; Imidazoles; Kidney; Kinetics; Ligands; Losartan; Mammals; Molecular Sequence Data; Mutagenesis, Site-Directed; Protein Structure, Secondary; Rats; Receptors, Angiotensin; Recombinant Proteins; Saralasin; Tetrazoles; Transfection; Xenopus	1995
Central ANG II-receptor antagonists impair cardiovascular and vasopressin response to hemorrhage in rats. The American journal of physiology, 1995, Volume: 268, Issue:6 Pt 2 Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Arginine Vasopressin; Biphenyl Compounds; Blood Pressure; Cerebral Ventricles; Heart Rate; Hemodynamics; Hemorrhage; Homeostasis; Imidazoles; Injections, Intraventricular; Losartan; Male; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Rats, Wistar; Reference Values; Renin; Saralasin; Species Specificity; Tetrazoles; Time Factors	1995
Alterations in glomerular dynamics in congenital, unilateral hydronephrosis. Kidney international, 1994, Volume: 46, Issue:1 Topics: Angiotensin II; Animals; Biphenyl Compounds; Bridged Bicyclo Compounds, Heterocyclic; Disease Models, Animal; Fatty Acids, Unsaturated; Glomerular Filtration Rate; Hydrazines; Hydronephrosis; Imidazoles; Kidney Glomerulus; Losartan; Male; Rats; Rats, Inbred Strains; Rats, Wistar; Saralasin; Tetrazoles; Thromboxane A2	1994
Effects of angiotensin II and angiotensin-(1-7) on the release of [3H]norepinephrine from rat atria. Hypertension (Dallas, Tex. : 1979), 1994, Volume: 24, Issue:4 Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biphenyl Compounds; Drug Interactions; Electric Stimulation; Female; Heart; Heart Atria; Imidazoles; Losartan; Myocardium; Norepinephrine; Peptide Fragments; Pyridines; Rats; Rats, Wistar; Receptors, Angiotensin; Saralasin; Tetrazoles	1994
Synthetic cDNA encoding the rat AT1a receptor: a useful tool for structure-function relationship analysis. Biochemical and biophysical research communications, 1994, Mar-30, Volume: 199, Issue:3 Topics: Angiotensin II; Angiotensin III; Angiotensin Receptor Antagonists; Animals; Base Sequence; Biphenyl Compounds; CHO Cells; Codon; Cricetinae; DNA, Complementary; Imidazoles; Kinetics; Losartan; Molecular Sequence Data; Mutagenesis, Site-Directed; Oligodeoxyribonucleotides; Oligopeptides; Open Reading Frames; Pyridines; Rats; Receptors, Angiotensin; Restriction Mapping; Saralasin; Signal Transduction; Structure-Activity Relationship; Tetrazoles; Transfection	1994
Differential regulation of angiotensin II and losartan binding sites in glomeruli and mesangial cells. The American journal of physiology, 1994, Volume: 266, Issue:3 Pt 2 Topics: Administration, Oral; Angiotensin II; Animals; Binding Sites; Biphenyl Compounds; Glomerular Mesangium; Imidazoles; In Vitro Techniques; Kidney Glomerulus; Losartan; Male; Rats; Rats, Wistar; Receptors, Angiotensin; RNA, Messenger; Saralasin; Tetrazoles	1994
Selective changes in angiotensin II AT1 and AT2 receptor subtypes in the rat superior colliculus following eye enucleation. Neuroscience, 1994, Volume: 58, Issue:4 Topics: Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Autoradiography; Biphenyl Compounds; Eye Enucleation; Geniculate Bodies; Imidazoles; Iodine Radioisotopes; Losartan; Male; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Retina; Saralasin; Subcellular Fractions; Superior Colliculi; Suprachiasmatic Nucleus; Synapses; Tetrazoles; Visual Pathways	1994
Characterization of putative glomerular receptors for angiotensin II in the rainbow trout Oncorhynchus mykiss using the antagonists Losartan, PD 123177, and saralasin. General and comparative endocrinology, 1993, Volume: 92, Issue:1 Topics: Analysis of Variance; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Imidazoles; Iodine Radioisotopes; Kidney Glomerulus; Kinetics; Losartan; Oncorhynchus mykiss; Pyridines; Receptors, Angiotensin; Saralasin; Tetrazoles	1993
Immunological reactivity of angiotensin II receptor antagonists: possible implications for receptor binding sites. European journal of pharmacology, 1993, Oct-15, Volume: 247, Issue:2 Topics: 1-Sarcosine-8-Isoleucine Angiotensin II; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antibodies, Monoclonal; Antihypertensive Agents; Biphenyl Compounds; Imidazoles; In Vitro Techniques; Indicators and Reagents; Iodine Radioisotopes; Losartan; Molecular Conformation; Oligopeptides; Pyridines; Rats; Receptors, Angiotensin; Saralasin; Tetrazoles	1993
Characterization of [3H]losartan receptors in isolated rat glomeruli. European journal of pharmacology, 1993, Oct-15, Volume: 247, Issue:2 Topics: Animals; Binding, Competitive; Biphenyl Compounds; Dithiothreitol; Guanosine 5'-O-(3-Thiotriphosphate); Imidazoles; In Vitro Techniques; Iodine Radioisotopes; Kidney Glomerulus; Losartan; Male; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Saralasin; Tetrazoles	1993
Oxytocic effect of trypsin on the isolated rat uterus. Hypertension (Dallas, Tex. : 1979), 1994, Volume: 23, Issue:1 Suppl Topics: Angiotensin I; Angiotensin II; Animals; Biphenyl Compounds; Bradykinin; Dose-Response Relationship, Drug; Enalaprilat; Female; Imidazoles; In Vitro Techniques; Isometric Contraction; Losartan; Oxytocin; Pepstatins; Rats; Saralasin; Tetrazoles; Trypsin; Uterine Contraction; Uterus	1994
Role of angiotensin II and AT1 receptors in hippocampal LTP. Pharmacology, biochemistry, and behavior, 1993, Volume: 45, Issue:2 Topics: Angiotensin II; Animals; Biphenyl Compounds; Diazepam; Electric Stimulation; Electrophysiology; Ethanol; Hippocampus; Imidazoles; Learning; Losartan; Male; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Saralasin; Tetrazoles	1993
Regulation of the urinary excretion of endothelin in the rat. American journal of hypertension, 1993, Volume: 6, Issue:6 Pt 1 Topics: Analysis of Variance; Angiotensin II; Animals; Antihypertensive Agents; Arginine Vasopressin; Biphenyl Compounds; Blood Pressure; Captopril; Dose-Response Relationship, Drug; Endothelins; Glomerular Filtration Rate; Imidazoles; Kidney; Losartan; Male; Nifedipine; Radioimmunoassay; Rats; Rats, Wistar; Saralasin; Tetrazoles	1993
Binding of angiotensin antagonists to rat liver and brain membranes measured ex vivo. British journal of pharmacology, 1993, Volume: 109, Issue:3 Topics: 1-Sarcosine-8-Isoleucine Angiotensin II; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Binding, Competitive; Biphenyl Compounds; Blood-Brain Barrier; Brain; Imidazoles; In Vitro Techniques; Iodine Radioisotopes; Liver; Losartan; Male; Membranes; Nicotinic Acids; Pyridines; Rats; Receptors, Angiotensin; Saralasin; Tetrazoles	1993
Anti-angiotensin antibodies cross-reactive with nonpeptide angiotensin antagonists as angiotensin receptor model. Regulatory peptides, 1993, Mar-19, Volume: 44, Issue:2 Topics: Adrenocorticotropic Hormone; Amino Acid Sequence; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antibodies; Biphenyl Compounds; Cross Reactions; Enzyme-Linked Immunosorbent Assay; Imidazoles; Losartan; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Naloxone; Pyridines; Saralasin; Structure-Activity Relationship; Tetrazoles	1993
Angiotensin II stimulates growth and steroidogenesis in zona fasciculata/reticularis cells from bovine adrenal cortex via the AT1 receptor subtype. Endocrinology, 1993, Volume: 132, Issue:5 Topics: Angiotensin II; Animals; Biphenyl Compounds; Cattle; Cell Division; Cells, Cultured; Hydrocortisone; Imidazoles; Losartan; Phosphoric Diester Hydrolases; Saralasin; Tetrazoles; Zona Fasciculata; Zona Reticularis	1993
Pharmacological characteristics of the positive inotropic effect of angiotensin II in the rabbit ventricular myocardium. British journal of pharmacology, 1993, Volume: 108, Issue:4 Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Bupranolol; Heart Ventricles; Imidazoles; In Vitro Techniques; Losartan; Male; Myocardial Contraction; Myocardium; Papillary Muscles; Phorbol 12,13-Dibutyrate; Phosphatidylinositols; Prazosin; Pyridines; Rabbits; Saralasin; Tetrazoles	1993
Identification and characterization of angiotensin II receptors in rat epididymal adipocyte membranes. Metabolism: clinical and experimental, 1993, Volume: 42, Issue:4 Topics: 1-Sarcosine-8-Isoleucine Angiotensin II; Adipose Tissue; Angiotensin II; Angiotensin III; Angiotensin Receptor Antagonists; Animals; Binding, Competitive; Biphenyl Compounds; Cell Membrane; Epididymis; Imidazoles; Losartan; Male; Peptidyl-Dipeptidase A; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Saralasin; Temperature; Tetrazoles	1993
Identification and characterisation of angiotensin II receptor subtypes in human brain. European journal of pharmacology, 1993, Jan-19, Volume: 230, Issue:3 Topics: Aged; Angiotensin II; Angiotensin Receptor Antagonists; Autoradiography; Binding, Competitive; Biphenyl Compounds; Brain Chemistry; Female; Humans; Imidazoles; In Vitro Techniques; Iodine Radioisotopes; Losartan; Male; Middle Aged; Pyridines; Radioligand Assay; Receptors, Angiotensin; Saralasin; Tetrazoles	1993
Characterization of angiotensin AT1A receptor isoform by its ligand binding signature. Regulatory peptides, 1993, Mar-19, Volume: 44, Issue:2 Topics: Adrenal Cortex; Angiotensin I; Angiotensin III; Animals; Base Sequence; Binding, Competitive; Biphenyl Compounds; CHO Cells; Cricetinae; Guanosine 5'-O-(3-Thiotriphosphate); Imidazoles; Losartan; Molecular Sequence Data; Muscle, Smooth, Vascular; Nicotinic Acids; Pyridines; Rats; Receptors, Angiotensin; Recombinant Proteins; Saralasin; Tetrazoles; Transfection	1993
Regulated expression of angiotensin II (AT2) binding sites in R3T3 cells. Regulatory peptides, 1993, Mar-19, Volume: 44, Issue:2 Topics: 1-Sarcosine-8-Isoleucine Angiotensin II; 3T3 Cells; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Bombesin; Cell Division; Fibroblast Growth Factor 2; Imidazoles; Losartan; Mice; Mitogens; Pyridines; Receptors, Angiotensin; Saralasin; Tetrazoles; Up-Regulation	1993
Angiotensin type 2 receptors mediate depressor phase of biphasic pressure response to angiotensin. The American journal of physiology, 1993, Volume: 264, Issue:5 Pt 2 Topics: Angiotensin II; Angiotensin III; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Blood Pressure; Dose-Response Relationship, Drug; Heart Rate; Imidazoles; Losartan; Male; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Saralasin; Tetrazoles	1993
Angiotensin II receptors are exclusively of the AT1 subtype in cultured human vascular smooth muscle cells. Biochemical Society transactions, 1995, Volume: 23, Issue:3 Topics: 1-Sarcosine-8-Isoleucine Angiotensin II; Angiotensin II; Angiotensin Receptor Antagonists; Binding, Competitive; Biphenyl Compounds; Cells, Cultured; Humans; Imidazoles; Kinetics; Losartan; Muscle, Smooth, Vascular; Oligopeptides; Receptors, Angiotensin; Saralasin; Tetrazoles	1995
Effects of angiotensin II receptor blockade during exercise: comparison of losartan and saralasin. Journal of cardiovascular pharmacology, 1996, Volume: 28, Issue:2 Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Biphenyl Compounds; Blood Pressure; Coronary Circulation; Heart Rate; Hemodynamics; Imidazoles; Losartan; Physical Exertion; Receptors, Angiotensin; Regional Blood Flow; Renal Circulation; Saralasin; Splanchnic Circulation; Swine; Swine, Miniature; Tetrazoles; Water-Electrolyte Balance	1996
Angiotensin II receptor type 1 on granulosa and thecal cells of rabbit preovulatory follicles. Biochimica et biophysica acta, 1996, Oct-23, Volume: 1284, Issue:2 Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Binding Sites; Biphenyl Compounds; Cells, Cultured; Chorionic Gonadotropin; Female; Gonadotropins, Equine; Granulosa Cells; Imidazoles; Kinetics; Losartan; Pyridines; Rabbits; Receptors, Angiotensin; Saralasin; Tetrazoles; Theca Cells; Up-Regulation	1996
Altered signal transduction system in hypertrophied myocardium: angiotensin II stimulates collagen synthesis in hypertrophied hearts. Journal of cardiac failure, 1996, Volume: 2, Issue:4 Suppl Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Biphenyl Compounds; Cardiomegaly; Cells, Cultured; Collagen; Fibroblasts; Imidazoles; Losartan; Male; Myocardium; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Renin-Angiotensin System; RNA, Messenger; Saralasin; Signal Transduction; Tetrazoles	1996
Selective blockade of AT1 angiotensin II receptors abolishes ischemic preconditioning in isolated rabbit hearts. Journal of molecular and cellular cardiology, 1997, Volume: 29, Issue:1 Topics: Analysis of Variance; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Coronary Circulation; Drug Evaluation, Preclinical; Female; Imidazoles; In Vitro Techniques; Ischemic Preconditioning, Myocardial; Losartan; Male; Myocardial Infarction; Myocardial Reperfusion; Rabbits; Renin-Angiotensin System; Saralasin; Tetrazoles; Ventricular Dysfunction, Left	1997
Murine double nullizygotes of the angiotensin type 1A and 1B receptor genes duplicate severe abnormal phenotypes of angiotensinogen nullizygotes. The Journal of clinical investigation, 1998, Feb-15, Volume: 101, Issue:4 Topics: Adrenal Glands; Anesthetics; Angiotensin II; Angiotensinogen; Animals; Benzimidazoles; beta-Galactosidase; Biphenyl Compounds; Blood Pressure; Imidazoles; Infusions, Intravenous; Kidney; Losartan; Mice; Mice, Knockout; Myocardium; Phenotype; Pyridines; Receptor, Angiotensin, Type 1; Receptors, Angiotensin; Saralasin; Staining and Labeling; Tetrazoles; Thiopental; Zygote	1998
A novel angiotensin II binding site in murine tissues. Life sciences, 1998, Volume: 63, Issue:3 Topics: Amino Acid Sequence; Angiotensin II; Animals; Autoradiography; Binding Sites; Humans; Imidazoles; Losartan; Mice; Mice, Inbred C57BL; Mice, Nude; Pyridines; Saralasin; Tumor Cells, Cultured	1998
Different receptors for angiotensin II at pre- and postjunctional level of the canine mesenteric and pulmonary arteries. British journal of pharmacology, 1998, Volume: 124, Issue:6 Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Dogs; Female; Imidazoles; Losartan; Male; Mesenteric Arteries; Neuroeffector Junction; Pulmonary Artery; Pyridines; Receptors, Angiotensin; Saralasin	1998
The role of angiotensin II and of its receptor subtypes in the acetic acid-induced abdominal constriction test. Pharmacology, biochemistry, and behavior, 1999, Volume: 62, Issue:2 Topics: Acetic Acid; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Colic; Imidazoles; Losartan; Male; Mice; Mice, Inbred ICR; Pain; Pain Measurement; Pyridines; Receptors, Angiotensin; Saralasin	1999
Activation of AT(2) receptors by endogenous angiotensin II is involved in flow-induced dilation in rat resistance arteries. Hypertension (Dallas, Tex. : 1979), 1999, Volume: 34, Issue:4 Pt 1 Topics: Analysis of Variance; Angiotensin II; Animals; Antihypertensive Agents; Blotting, Western; Imidazoles; Losartan; Mesenteric Arteries; Pyridines; Rats; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Reverse Transcriptase Polymerase Chain Reaction; Saralasin; Stress, Mechanical; Vascular Resistance; Vasodilation	1999
Renal effects of angiotensin II receptor subtype 1 and 2-selective ligands injected into the paraventricular nucleus of conscious rats. Regulatory peptides, 1999, Oct-22, Volume: 84, Issue:1-3 Topics: Angiotensin II; Animals; Injections, Intraventricular; Kidney; Ligands; Losartan; Male; Oligopeptides; Paraventricular Hypothalamic Nucleus; Potassium; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Saralasin; Sodium	1999
Interaction between Mas and the angiotensin AT1 receptor in the amygdala. Journal of neurophysiology, 2000, Volume: 83, Issue:4 Topics: Action Potentials; Amygdala; Angiotensin II; Animals; Antihypertensive Agents; Electrophysiology; Immunoenzyme Techniques; In Vitro Techniques; Losartan; Mice; Mice, Knockout; Proto-Oncogene Mas; Proto-Oncogene Proteins; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Receptors, G-Protein-Coupled; Saralasin; Vasoconstrictor Agents	2000
Role of adrenal renin-angiotensin system in the control of aldosterone secretion in sodium-restricted rats. American journal of physiology. Endocrinology and metabolism, 2000, Volume: 278, Issue:6 Topics: Adrenal Glands; Aldosterone; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Captopril; Diet, Sodium-Restricted; Losartan; Male; Potassium; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Renin-Angiotensin System; Saralasin	2000
Octreotide-induced drinking, vasopressin, and pressure responses: role of central angiotensin and ACh. American journal of physiology. Regulatory, integrative and comparative physiology, 2000, Volume: 279, Issue:1 Topics: Acetylcholine; Analysis of Variance; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Behavior, Animal; Blood Pressure; Dose-Response Relationship, Drug; Drinking; Injections, Intraventricular; Injections, Subcutaneous; Losartan; Male; Muscarinic Antagonists; Narcotic Antagonists; Octreotide; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Saralasin; Vasopressins	2000
Reinforcement of arteriolar myogenic activity by endogenous ANG II: susceptibility to dietary salt. American journal of physiology. Heart and circulatory physiology, 2000, Volume: 279, Issue:1 Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Arterioles; Blood Pressure; Bradykinin; Diet, Sodium-Restricted; Losartan; Male; Microcirculation; Muscle, Skeletal; Muscle, Smooth, Vascular; Rats; Rats, Inbred WKY; Saralasin; Sodium, Dietary	2000
Contribution of angiotensin II, endothelin 1 and the endothelium to the slow inotropic response to stretch in ferret papillary muscle. Pflugers Archiv : European journal of physiology, 2001, Volume: 441, Issue:4 Topics: Angiotensin II; Animals; Endothelin-1; Endothelium; Female; Ferrets; Kinetics; Losartan; Male; Muscle Spindles; Myocardial Contraction; Octoxynol; Oligopeptides; Papillary Muscles; Peptides, Cyclic; Saralasin	2001
Angiotensin receptor in the heart of Bothrops jararaca snake. European journal of pharmacology, 2001, Apr-06, Volume: 417, Issue:1-2 Topics: 1-Sarcosine-8-Isoleucine Angiotensin II; Angiotensin Amide; Angiotensin II; Animals; Binding, Competitive; Bothrops; Colforsin; Cyclic AMP; Dose-Response Relationship, Drug; Female; Imidazoles; Inositol Phosphates; Losartan; Male; Membranes; Myocardium; Pyridines; Receptors, Angiotensin; Saralasin; Tritium	2001
Angiotensin-(1-7) reverts the stimulatory effect of angiotensin II on the proximal tubule Na(+)-ATPase activity via a A779-sensitive receptor. Regulatory peptides, 2002, Jan-15, Volume: 103, Issue:1 Topics: Angiotensin I; Angiotensin II; Angiotensin III; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Cell Membrane; Dose-Response Relationship, Drug; Imidazoles; In Vitro Techniques; Kidney Tubules, Proximal; Losartan; Peptide Fragments; Pyridines; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Saralasin; Sodium-Potassium-Exchanging ATPase; Swine	2002
Differential effect of angiotensin II on blood circulation in the renal medulla and cortex of anaesthetised rats. The Journal of physiology, 2002, Jan-01, Volume: 538, Issue:Pt 1 Topics: Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Imidazoles; Kidney Cortex; Kidney Medulla; Losartan; Male; Pyridines; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Renal Circulation; Saralasin; Vasoconstrictor Agents	2002
Influence of angiotensin II receptor subtypes of the paraventricular nucleus on the physiological responses induced by angiotensin II injection into the medial septal area. Arquivos brasileiros de cardiologia, 2003, Volume: 80, Issue:4 Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Blood Pressure; Diuresis; Drinking; Homeostasis; Imidazoles; Losartan; Male; Paraventricular Hypothalamic Nucleus; Pyridines; Rats; Rats, Sprague-Dawley; Saralasin; Septum of Brain; Sodium; Vasoconstrictor Agents	2003
The effects of peptide and nonpeptide antagonists of angiotensin II receptors on the noradrenaline uptake of different brain structures in rats with angiotensin II-induced increase of water intake. Acta physiologica et pharmacologica Bulgarica, 2003, Volume: 27, Issue:2-3 Topics: Analysis of Variance; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Brain; Drinking Behavior; Imidazoles; Losartan; Male; Norepinephrine; Rats; Rats, Wistar; Saralasin; Tetrazoles	2003
Pharmacological properties of angiotensin II receptors in cultured rabbit gingival fibroblasts. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP, 2004, Volume: 137, Issue:3 Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin Receptor Antagonists; Animals; Benzimidazoles; Binding, Competitive; Biphenyl Compounds; Blotting, Western; Cell Division; Cells, Cultured; Dose-Response Relationship, Drug; Fibroblasts; Gingiva; Kinetics; Losartan; Rabbits; Radioligand Assay; Receptors, Angiotensin; Saralasin; Tetrazoles; Tritium	2004
Angiotensin II inhibition of Ca2+ currents is independent of ATR1 angiotensin II receptor activation in rat adult vagal afferent neurons. Autonomic neuroscience : basic & clinical, 2005, Feb-07, Volume: 117, Issue:2 Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Calcium Channel Blockers; Calcium Channels; Cells, Cultured; Drug Interactions; Losartan; Membrane Potentials; Neural Inhibition; Neurons, Afferent; Nifedipine; Nodose Ganglion; Patch-Clamp Techniques; Rats; Receptor, Angiotensin, Type 1; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Saralasin	2005
The role of angiotensin II in the early stages of bovine ovulation. Reproduction (Cambridge, England), 2007, Volume: 134, Issue:5 Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin II Type 2 Receptor Blockers; Angiotensin Receptor Antagonists; Animals; Cattle; Female; Gonadotropin-Releasing Hormone; Imidazoles; Injections; Losartan; Luteinizing Hormone; Ovarian Follicle; Ovulation; Pyridines; Random Allocation; Receptor, Angiotensin, Type 2; Renin-Angiotensin System; Saralasin; Ultrasonography	2007
Intracellular angiotensin II activates rat myometrium. American journal of physiology. Cell physiology, 2011, Volume: 301, Issue:3 Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin II Type 2 Receptor Blockers; Animals; Arsenicals; Autophagy; Brefeldin A; Calcium Signaling; Carbolines; Cells, Cultured; Egtazic Acid; Endocytosis; Endoplasmic Reticulum; Endosomes; Enzyme Inhibitors; Estrenes; Female; Heparin; Imidazoles; Inositol 1,4,5-Trisphosphate Receptors; Losartan; Lysosomes; Macrocyclic Compounds; Macrolides; Models, Biological; Myometrium; NADP; Oxazoles; Piperazines; Pyridines; Pyrrolidinones; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Ryanodine; Saralasin; Signal Transduction; Sirolimus; Type C Phospholipases; Uterus	2011
In vitro method of studying the angiotensin activity of chemical compounds. Bulletin of experimental biology and medicine, 2014, Volume: 158, Issue:1 Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Drug Evaluation, Preclinical; Female; In Vitro Techniques; Inhibitory Concentration 50; Losartan; Male; Muscle Contraction; Muscle, Smooth, Vascular; Portal Vein; Rats, Wistar; Saralasin; Vasoconstriction	2014