losartan has been researched along with ng-nitroarginine methyl ester in 161 studies
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 68 (42.24) | 18.2507 |
| 2000's | 61 (37.89) | 29.6817 |
| 2010's | 27 (16.77) | 24.3611 |
| 2020's | 5 (3.11) | 2.80 |
| Authors | Studies |
|---|---|
| Beierwaltes, WH; Carretero, OA; Sigmon, DH | 2 |
| Antunes, E; de Nucci, G; Lovisolo, SM; Ribeiro, MO; Zatz, R | 1 |
| Bennett, T; Compton, AM; Foulkes, R; Gardiner, SM; Hughes, B; Kemp, PA | 1 |
| Jover, B; Mimran, A; Nafrialdi, N | 1 |
| De Nucci, G; Fujihara, CK; Zatz, R | 1 |
| Brunner, HR; Grouzmann, E; Nussberger, J; Osterheld, MC; Schaad, NC; Waeber, B; Zanchi, A | 1 |
| Hartman, JC | 1 |
| Cachofeiro, V; Lahera, V; Maeso, R; Navarro, J; Rodrigo, E; Ruilope, LM | 1 |
| Hamann, M; Hegyi, I; Kaissling, B; Kurtz, A; Schricker, K | 1 |
| Ahima, RS; Kadowitz, PJ; Khosla, MC; Minkes, RK; Osei, SY; Weaver, JP | 1 |
| Carretero, OA; Farhy, RD; Ho, KL; Scicli, AG | 1 |
| Bennett, T; Gardiner, SM; Kemp, PA; March, JE; Rakhit, T | 1 |
| Beierwaltes, WH; Newman, JM; Sigmon, DH | 1 |
| Anderson, S; Houghton, DC; Tank, JE; Vora, JP | 1 |
| Chiyotani, A; Isono, K; Konno, K; Sugimoto, F; Tagaya, E; Tamaoki, J | 1 |
| Jover, B; Mimran, A | 1 |
| Baylis, C; Engels, K; Qiu, C | 1 |
| Dick, LB; Guan, H; Lin, L; Miller, KB; Nasjletti, A; Pucci, ML | 1 |
| Barrett, RJ; Droppleman, DA | 1 |
| Beierwaltes, WH; Sigmon, DH | 3 |
| Barbant, SD; Chatterjee, K; Gupta, M; MacGregor, JS; Redberg, R; Sudhir, K; Yock, PG | 1 |
| Baylis, C; Engels, K; Harton, P; Samsell, L | 1 |
| Dupont, M; Herizi, A; Jover, B; Mimran, A; Ventre, F | 1 |
| Cachofeiro, V; Guan, H; Kaminski, PM; Nasjletti, A; Pucci, ML; Wolin, MS | 1 |
| Brecher, P; Chobanian, AV; Hou, J; Kato, H | 1 |
| Fink, GD; Melaragno, MG | 1 |
| Domergue, V; Giudicelli, JF; Richer, C; Vincent, MP | 1 |
| Adachi, Y; Hashimoto, K; Hisa, H; Satoh, S; Suzuki-Kusaba, M; Yoshida, M | 1 |
| Cox, SL; Story, DF; Ziogas, J | 1 |
| Blanc, J; Elghozi, JL; Gaudet, E; Gouédard, O; Ponchon, P | 2 |
| Cachofeiro, V; Lahera, V; Maeso, R; Muñoz-García, R; Navarro-Cid, J; Rodrigo, E; Ruilope, LM | 4 |
| Hamaguchi, A; Iwao, H; Kim, S; Ohta, K; Takaori, K; Yagi, K | 1 |
| Lee, BH; Shin, HS | 1 |
| Carey, RM; Siragy, HM | 1 |
| Bolla, BS; de Guzman, FQ; Hussain, Y; Igić, R; Montiague, RR; Rabito, SF; Rajani, V | 1 |
| Comiter, CV; Kifor, I; Sullivan, MP; Yalla, SV | 1 |
| Dall'Aglio, P; Fasoli, E; Giberti, D; Montanari, A; Novarini, A; Perinotto, P; Tateo, E | 1 |
| Gohlke, P; Pees, C; Unger, T | 2 |
| Arnal, JF; Michel, JB; Pueyo, ME; Rami, J | 1 |
| Liu, JL; Murakami, H; Zucker, IH | 1 |
| Kadekaro, M; Liu, H; Summy-Long, JY; Terrell, ML | 1 |
| Cardinal, R; de Champlain, J; Foucart, S; K-Laflamme, A; Lambert, C; Moreau, P | 1 |
| Andoh, TF; Bennett, WM; Couser, WG; Johnson, RJ; Pichler, RH; Shankland, SJ; Thomas, SE | 1 |
| Carbonell, LF; Delgado, JL; Hernández, I; Pérez, MC; Quesada, T | 1 |
| Atucha, NM; Fortepiani, LA; García-Estañ, J; Ortíz, MC; Ruiz-Marcos, FM | 1 |
| Hagiwara, Y; Hanada, M; Kambe, T; Kubo, T; Saito, E | 1 |
| Demeilliers, B; Herizi, A; Jover, B; Mimran, A | 1 |
| Brecher, P; Chobanian, AV; Du, Y; Gavras, H; Makaritsis, KP | 1 |
| Hirata, K; Kanazawa, H; Yoshikawa, J | 1 |
| Baylis, C; Engels, K; Harvey, J; Santmyire, BR | 1 |
| Cardinal, R; de Champlain, J; K-Laflamme, A; Oster, L | 1 |
| Anderson, NH; Devlin, AM; Dominiczak, AF; Graham, D; Hamilton, CA; Morton, JJ; Reid, JL; Schork, NJ | 1 |
| Block, ER; Hill-Kapturczak, N; Kapturczak, MH; Madsen, KM; Malinski, T; Patel, JM; Tisher, CC | 1 |
| Kähönen, M; Kalliovalkama, J; Karjala, K; Mäkynen, H; Pörsti, I; Tolvanen, JP; Wu, X | 1 |
| Carbonell, LF; Fenoy, FJ; Hernández, I; Quesada, T | 1 |
| Musch, TI; Stebbins, CL; Symons, JD | 1 |
| Ardaillou, R; Chansel, D; Henrion, D; Levy, BI; Loufrani, L | 1 |
| Holm, P; Hutri-Kähönen, N; Jolma, P; Kähönen, M; Kalliovalkama, J; Pörsti, I; Tolvanen, JP; Wu, X | 1 |
| D'Amours, M; Grose, JH; Larivière, R; Lebel, M | 1 |
| Ardaillou, R; Boffa, JJ; Chatziantoniou, C; Dussaule, JC; Placier, S; Tharaux, PL | 1 |
| Blanc, J; Elghozi, JL; Jover, B; Laude, D; Ponchon, P | 1 |
| Cierco, M; Israel, A; Sosa, B | 1 |
| Arroyo, V; Bataller, R; Bosch, J; Garcia-Ramallo, E; Gasull, X; Ginès, P; Görbig, MN; Nicolás, JM; Rodés, J | 1 |
| Cierco, M; Gutierrez, CI; Israel, A; Sosa-Canache, B | 1 |
| Bui, V; Kadekaro, M; Liu, H; Summy-Long, JY; Terrell, ML | 1 |
| Manucha, WA; Valles, PG | 1 |
| DE Gracia, MC; Del Moral, RG; Del Rio, CG; O'Valle, F; Osuna, A; Vargas, F; Wangensteen, R | 1 |
| Buczko, W; Chabielska, E; Kucharewicz, I; Matys, T; Pawlak, R | 1 |
| Harada, S; Hatta, T; Itoh, H; Kawa, T; Nakagawa, M; Nakata, T; Oguni, A; Sasaki, S; Takeda, K | 1 |
| Chopra, K; Kulkarni, SK; Raghavendra, V | 1 |
| Biggi, A; Carra, N; Dall'aglio, P; Montanari, A; Novarini, A; Orrico, A; Perinotto, P; Valmadre, G | 1 |
| Asakura, M; Asanuma, H; Fukushima, T; Hori, M; Kitakaze, M; Kuzuya, T; Liao, Y; Minamino, T; Node, K; Ogai, A; Ogita, H; Sakata, Y; Sanada, S; Takashima, S; Yamada, J | 1 |
| Bautista, R; Escalante, B; Hernández, J; Oyekan, A; Sánchez, A | 1 |
| Carey, RM; Howell, NL; Jin, XH; Siragy, HM | 1 |
| Bergamaschi, CT; Biancardi, VC; Campos, RR; Lopes, OU | 1 |
| Dobesová, Z; Kunes, J; Zicha, J | 1 |
| Inoue, K; Kitaura, Y; Kubota, J; Nishimura, H | 1 |
| Chang, FY; Hou, MC; Huang, YT; Lee, FY; Lee, SD; Lee, TY; Lin, HC; Liu, RS; Yang, YY | 1 |
| Aukland, K; Roald, AB; Tenstad, O; Treeck, B | 1 |
| Arican, N; Cimen, V; Elmas, I; Kalayci, R; Kaya, M; Korkut, F; Kucuk, M; Kudat, H | 1 |
| Jolma, P; Kalliovalkama, J; Pörsti, I; Ruskoaho, H; Suo, M; Tolvanen, JP; Vuolteenaho, O | 1 |
| de Godoy, MA; de Oliveira, AM | 1 |
| Buczko, W; Chabielska, E; Kalinowski, L; Malinski, T; Matys, T | 1 |
| Deng, AY; Dobesova, Z; Hamet, P; Jacob, HJ; Kunes, J; Pausova, Z; Sun, YL; Tremblay, J; Ueno, T; Zicha, J | 1 |
| Boomsma, F; van den Meiracker, AH; van der Linde, NA | 1 |
| Grötsch, H; Hropot, M; Langer, KH; Linz, W; Wiemer, G | 1 |
| Giacca, A; Lapointe, N; Leung, N; Lewis, GF; Rouleau, JL; Szeto, L; Uffelman, KD; Wang, CH | 1 |
| Berg, T | 1 |
| Duarte, J; Moreno, JM; Osuna, A; Rodríguez-Gómez, I; Sainz, J; Vargas, F; Wangensteen, R | 1 |
| Bentley, MD; Fortepiani, LA; Garcia-Estan, J; Passardi, F; Ritman, EL; Romero, JC; Ruiz, MC | 1 |
| Kadekaro, M; Salas, N; Summy-Long, JY; Terrell, ML | 1 |
| Crozier, S; Endre, ZH; Gobe, G; Guan, Z; Manley, SW; Matthias, A; Willgoss, DA | 1 |
| Ketabchi, F; Najafipour, H | 1 |
| Arican, N; Elmas, I; Kalayci, R; Kaya, M; Korkut, F; Küçük, M; Kudat, H | 1 |
| Alanko, J; Jolma, P; Kalliovalkama, J; Kööbi, P; Pörsti, I; Riutta, A; Tolvanen, JP | 1 |
| Bäcker, A; Heller, J; Horacek, V; Kramer, HJ; Vaneckova, I | 1 |
| Deng, AY; Dobesová, Z; Hamet, P; Jacob, HJ; Kunes, J; Pausova, Z; Sun, Y; Tremblay, J; Ueno, T; Zicha, J | 1 |
| Beierwaltes, WH; Lum, C; Potter, DL; Shesely, EG | 1 |
| Drenjancevic-Peric, I; Frisbee, JC; Lombard, JH; Phillips, SA | 1 |
| Anand-Srivastava, MB; Hashim, S | 1 |
| de Godoy, MA; de Oliveira, AM; Rattan, S | 1 |
| Casarini, DE; Cavaglieri, Rde C; Dellê, H; Dominguez, WV; Graciano, ML; Malheiros, DM; Noronha, IL | 1 |
| Alonso, MJ; Balfagón, G; Rossoni, LV; Salaices, M; Vassallo, DV; Xavier, FE | 1 |
| Bennett, T; Davenport, AP; Gardiner, SM; Kemp, PA; March, JE; Wiley, KE | 1 |
| Bennett, T; Gardiner, SM; Kemp, PA; March, JE | 1 |
| Ma, R; Wang, W; Zhu, GQ | 1 |
| Frohlich, ED; Matavelli, LC; Ono, H; Zhou, X | 1 |
| Berti, F; Bianchi, M; Bonomo, S; De Gennaro Colonna, V; Ferrario, P; Fioretti, S; Manfredi, B; Muller, EE; Rigamonti, A; Rossoni, G | 1 |
| Ahmad, M; Al-Shabanah, OA; Khattab, M; Raza, M | 1 |
| Alenina, N; Almeida, AP; Bader, M; Castro, CH; Ferreira, AJ; Santos, RA | 1 |
| Berti, F; Bonomo, S; De Gennaro Colonna, V; Fioretti, S; Manfredi, B; Muller, EE; Rigamonti, A; Rossoni, G | 1 |
| Hussain, T; Siddiqui, AH | 1 |
| da Cruz-Höfling, MA; da Silva, GH; Hyslop, S; Paffaro, VA; Pauli, JR; Saad, MJ; Salgado, I; Tarsitano, CA | 1 |
| Jerkić, M; Jovović, D; Marković-Lipkovski, J; Mihailović-Stanojević, N; Milanović, JG; Miloradović, Z; Stosić, G | 1 |
| Gironacci, MM; Peña, C; Polizio, AH; Tomaro, ML | 1 |
| Akita, Y; Imamura, H; Iwasaka, T; Matsuhisa, S; Moriguchi, A; Okazaki, T; Otani, H; Sato, D; Yamashita, K | 1 |
| Akita, Y; Iwasaka, T; Matsuhisa, S; Moriguchi, A; Okazaki, T; Otani, H; Sato, D; Yamashita, K | 1 |
| Akira, T; Egi, Y; Maruyama, T; Matsumura, Y; Ohkita, M; Sasaoka, T; Takaoka, M; Tawa, M; Yamamoto, A | 1 |
| Costa, CA; Criddle, DN; Espinoza, LA; Marins de Carvalho, LC; Ognibene, DT; Oliveira, PR; Resende, AC; Soares de Moura, R; Tano, T | 1 |
| Agharazii, M; Bélanger, S; Larivière, R; Lebel, M; Lemieux, P; Therrien, F | 1 |
| Bagchi, D; Echard, B; Perricone, NV; Preuss, HG | 1 |
| Cassis, LA; Daugherty, A; Guo, Z; McNamara, CA; Moorleghen, JJ; Owens, AP; Subramanian, V | 1 |
| Chatziantoniou, C; Helle, F; Iversen, BM | 1 |
| Artyushkova, EB; Belous, AS; Kochkarov, VI; Pashin, EN; Pokrovskaya, TG; Pokrovskii, MV; Zhavbert, ES | 1 |
| Durand, MJ; Greene, AS; Lombard, JH; Moreno, C | 1 |
| Herring, N; Lee, CW; Paterson, DJ; Sunderland, N; Wright, K | 1 |
| Barreto-Chaves, ML; Carrillo-Sepúlveda, MA; Chies, AB; da Silva, OG; Rossignoli, Pde S | 1 |
| Angeli, JK; Casali, EA; Fürstenau, CR; Ramos, DB; Sarkis, JJ; Souza, DO; Stefanon, I; Vassallo, DV | 1 |
| Clouatre, DL; Preuss, HG; Rao, SN | 1 |
| Chaswal, M; Das, S; Fahim, M; Katyal, A; Mishra, AK; Prasad, J | 1 |
| Chatziantoniou, C; Dussaule, JC; Guerrot, D; Mael-Ainin, M; Placier, S; Rondeau, E; Xu-Dubois, YC | 1 |
| Cao, W; Chai, W; Liu, Z; Tao, L; Wang, N; Zhao, L | 1 |
| Dunning, L; Ferrell, WR; Lockhart, JC; Mackenzie, A | 1 |
| Biggi, A; Boeti, L; Cabassi, A; Cherney, DZ; Crocamo, A; Montanari, A; Musiari, L; Pelà, G | 1 |
| Almeida, JF; Alves, GM; Castro, CH; Colugnati, DB; Ferreira, AJ; Macedo, LM; Mendes, EP; Porto, JE; Santos, RA; Sobrinho, DB; Souza, ÁP; Vêncio, EF | 1 |
| Abdulla, MH; Johns, EJ | 2 |
| Almenara, CC; Angeli, JK; Broseghini-Filho, GB; Faria, Tde O; Padilha, AS; Stefanon, I; Vassallo, DV; Vescovi, MV | 1 |
| de Oliveira Faria, T; Furieri, LB; Lizardo, JH; Padilha, AS; Silveira, EA; Siman, FD; Stefanon, I; Vassallo, DV; Vescovi, MV | 1 |
| Flavahan, NA; Flavahan, S; Leung, SW; Vanhoutte, PM; Xu, A; Zhao, Y | 1 |
| Arcaya, JL; Chávez, M; Correia, D; Fernández, A; Finol, E; Pérez, M; Rincón, J; Romero, F; Summer, R; Talavera, E; Yaguas, K | 1 |
| Chatsudthipong, V; Kongrat, S; Muanprasat, C; Srisawat, U | 1 |
| Brzozowski, T; Konturek, SJ; Korbut, R; Kwiecien, S; Madej, J; Olszanecki, R; Pajdo, R; Pawlik, MW; Ptak-Belowska, A; Suski, M; Targosz, A | 1 |
| Cabassi, A; Cherney, DZI; Crocamo, A; Lazzeroni, D; Lytvyn, Y; Montanari, A; Musiari, L; Pelà, G | 1 |
| De Mey, JG; Janssen, B; Lemkens, P; Meens, MJ; Nelissen, J; Peters, SL; Schiffers, PM; Spijkers, LJ | 1 |
| Aghaei, I; Arjmand, S; Shabani, M; Tondar, M; Yousefzadeh Chabok, S | 1 |
| Abd-Eldayem, AM; Abdel-Zaher, AO; El-Refaiy, AEM; Farghaly, HSM | 1 |
| Ahmed, MM; Kamar, SS; Mahmoud, MM; Rashed, L; Sabry, MM; Shoukry, HS | 1 |
| Adumekwe, CW; Agomuo, EN; Amadi, PU | 1 |
| Andereggen, L; Kashefiolasl, S; Konczalla, J; Marbacher, S; Mrosek, J; Wanderer, S | 1 |
| Kamkar-Del, Y; Mohebbati, R; Shafei, MN | 1 |
| Ali, NA; El Gendy, ANG; Farrag, AH; Mohamed, SH; Ragab, TIM; Shalaby, ASG; Shalby, AB | 1 |
| Ahante, E; Anachuna, KK; Asiwe, JN; Ben-Azu, B; Edje, KE; Eduviere, AT; Moke, EG; Oghoghovwe, IJ; Omogbai, EKI; Omogbiya, AI; Osagie-Eweka, SDE; Uchendu, AP; Umukoro, EK | 1 |
1 review(s) available for losartan and ng-nitroarginine methyl ester
| Article | Year |
|---|---|
Modulatory properties of cardiac and quercetin glycosides from Dacryodes edulis seeds during L-NAME-induced vascular perturbation.
Topics: Animals; Biomarkers; Burseraceae; Cardiac Glycosides; Dose-Response Relationship, Drug; Drug Synergism; Endothelium, Vascular; Losartan; Male; Metoprolol; Mice; NG-Nitroarginine Methyl Ester; Plant Extracts; Quercetin; Rats; Seeds | 2020 |
5 trial(s) available for losartan and ng-nitroarginine methyl ester
| Article | Year |
|---|---|
Angiotensin II blockade does not prevent renal effects of L-NAME in sodium-repleted humans.
Topics: Adult; Angiotensin II; Biphenyl Compounds; Enzyme Inhibitors; Female; Humans; Imidazoles; Kidney; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Sodium, Dietary; Tetrazoles | 1997 |
Angiotensin II and prostaglandin interactions on systemic and renal effects of L-NAME in humans.
Topics: Adult; Angiotensin II; Blood Pressure; Cyclooxygenase Inhibitors; Drug Synergism; Enzyme Inhibitors; Female; Humans; Indomethacin; Kidney; Losartan; Male; NG-Nitroarginine Methyl Ester; Prostaglandins; Renal Circulation; Sodium; Vasoconstriction | 2001 |
Role of angiotensin II in L-NAME-induced systemic and renal hemodynamic effects in hydrochlorothiazide-pretreated hypertensive subjects.
Topics: Angiotensin II; Antihypertensive Agents; Diuresis; Diuretics; Drug Synergism; Drug Therapy, Combination; Enzyme Inhibitors; Glomerular Filtration Rate; Hemodynamics; Hormones; Humans; Hydrochlorothiazide; Hypertension; Losartan; Male; Middle Aged; Natriuresis; NG-Nitroarginine Methyl Ester; Renal Circulation; Sodium Chloride Symporter Inhibitors | 2003 |
Nitric oxide-angiotensin II interactions and renal hemodynamic function in patients with uncomplicated type 1 diabetes.
Topics: Adult; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Biomarkers; Case-Control Studies; Diabetes Mellitus, Type 1; Enzyme Inhibitors; Glomerular Filtration Rate; Hemodynamics; Humans; Kidney; Losartan; Male; Natriuresis; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Renal Circulation; Renin-Angiotensin System; Signal Transduction; Up-Regulation; Young Adult | 2013 |
Calcium channel blockade blunts the renal effects of acute nitric oxide synthase inhibition in healthy humans.
Topics: Adult; Arterial Pressure; Biomarkers; Calcium Channel Blockers; Dihydropyridines; Dinoprost; Enzyme Inhibitors; Female; Glomerular Filtration Rate; Healthy Volunteers; Hemodynamics; Humans; Infusions, Intravenous; Kidney; Losartan; Male; Natriuresis; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitrobenzenes; Oxidative Stress; Piperazines; Renal Circulation; Time Factors | 2017 |
155 other study(ies) available for losartan and ng-nitroarginine methyl ester
| Article | Year |
|---|---|
Angiotensin dependence of endothelium-mediated renal hemodynamics.
Topics: Angiotensin II; Animals; Arginine; Biphenyl Compounds; Blood Pressure; Enalaprilat; Endothelium, Vascular; Hemodynamics; Imidazoles; Kinins; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Sprague-Dawley; Renal Circulation; Tetrazoles | 1992 |
Plasma renin activity and the renal response to nitric oxide synthesis inhibition.
Topics: Animals; Arginine; Biphenyl Compounds; Blood Pressure; Imidazoles; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Sprague-Dawley; Renal Circulation; Renin; Tetrazoles | 1992 |
Chronic inhibition of nitric oxide synthesis. A new model of arterial hypertension.
Topics: Animals; Antihypertensive Agents; Arginine; Biphenyl Compounds; Blood Pressure; Hemodynamics; Hypertension; Imidazoles; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Inbred Strains; Renal Circulation; Tail; Tetrazoles; Time Factors | 1992 |
Haemodynamic effects of human alpha-calcitonin gene-related peptide following administration of endothelin-1 or NG-nitro-L-arginine methyl ester in conscious rats.
Topics: Angiotensin II; Animals; Arginine; Biphenyl Compounds; Blood Pressure; Calcitonin Gene-Related Peptide; Captopril; Endothelins; Heart Rate; Hemodynamics; Hindlimb; Imidazoles; In Vitro Techniques; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitroarginine; Rats; Regional Blood Flow; Renal Circulation; Splanchnic Circulation; Tetrazoles; Vasoconstriction | 1991 |
Endogenous vasoactive systems and the pressor effect of acute N omega-nitro-L-arginine methyl ester administration.
Topics: Adrenergic alpha-Antagonists; Angiotensin II; Animals; Arginine; Biphenyl Compounds; Blood Pressure; Desoxycorticosterone; Diet, Sodium-Restricted; Enalapril; Imidazoles; Losartan; Male; NG-Nitroarginine Methyl Ester; Nicardipine; Nitric Oxide; Rats; Rats, Wistar; Renin-Angiotensin System; Tetrazoles; Vasoconstriction | 1994 |
Chronic nitric oxide synthase inhibition aggravates glomerular injury in rats with subtotal nephrectomy.
Topics: Amino Acid Oxidoreductases; Angiotensin Receptor Antagonists; Animals; Arginine; Biphenyl Compounds; Glomerulosclerosis, Focal Segmental; Hemodynamics; Hypertrophy; Imidazoles; Kidney; Kidney Glomerulus; Losartan; Male; Nephrectomy; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Rats; Rats, Wistar; Renal Circulation; Tetrazoles; Time Factors | 1995 |
Effects of chronic NO synthase inhibition in rats on renin-angiotensin system and sympathetic nervous system.
Topics: Amino Acid Oxidoreductases; Analysis of Variance; Animals; Antihypertensive Agents; Arginine; Biphenyl Compounds; Blood Pressure; Brain; Creatinine; Diet, Sodium-Restricted; Epinephrine; Heart Rate; Hypertension; Imidazoles; Kidney; Losartan; Male; Neuropeptide Y; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Norepinephrine; Phentolamine; Rats; Rats, Wistar; Reference Values; Renin; Renin-Angiotensin System; Sympathetic Nervous System; Tetrazoles; Weight Gain | 1995 |
The role of bradykinin and nitric oxide in the cardioprotective action of ACE inhibitors.
Topics: Adrenergic beta-Antagonists; Amino Acid Oxidoreductases; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Arginine; Biphenyl Compounds; Bradykinin; Bradykinin Receptor Antagonists; Heart; Imidazoles; Losartan; Myocardial Infarction; Myocardial Ischemia; Myocardial Reperfusion; Myocardial Reperfusion Injury; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Rabbits; Ramipril; Receptors, Angiotensin; Receptors, Bradykinin; Tetrazoles | 1995 |
Nitric oxide and prostaglandins in the prolonged effects of losartan and ramipril in hypertension.
Topics: Animals; Antihypertensive Agents; Arginine; Biphenyl Compounds; Blood Pressure; Bradykinin; Drug Interactions; Hypertension; Imidazoles; Indomethacin; Kidney Function Tests; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Prostaglandins; Ramipril; Rats; Rats, Inbred SHR; Tetrazoles | 1995 |
Tonic stimulation of renin gene expression by nitric oxide is counteracted by tonic inhibition through angiotensin II.
Topics: Analysis of Variance; Angiotensin II; Animals; Arginine; Biphenyl Compounds; Enzyme Precursors; Enzyme Repression; Gene Expression Regulation, Enzymologic; Imidazoles; Indomethacin; Kidney; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Ramipril; Rats; Rats, Sprague-Dawley; Renin; RNA, Messenger; Tetrazoles | 1995 |
Differential responses to angiotensin-(1-7) in the feline mesenteric and hindquarters vascular beds.
Topics: Amino Acid Oxidoreductases; Angiotensin I; Angiotensin II; Angiotensin III; Animals; Arginine; Biphenyl Compounds; Cats; Hindlimb; Imidazoles; Losartan; Meclofenamic Acid; Mesenteric Artery, Superior; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Peptide Fragments; Perfusion; Tetrazoles; Vascular Resistance; Vasoconstriction | 1993 |
Role of kinins and nitric oxide in the effects of angiotensin converting enzyme inhibitors on neointima formation.
Topics: Amino Acid Oxidoreductases; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Arginine; Biphenyl Compounds; Bradykinin; Carotid Arteries; Imidazoles; Kinins; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Receptors, Bradykinin; Receptors, Neurotransmitter; Tetrazoles; Tunica Intima | 1993 |
Regional haemodynamic responses to pituitary adenylate cyclase-activating polypeptide and vasoactive intestinal polypeptide in conscious rats.
Topics: Adrenergic beta-Antagonists; Angiotensin II; Animals; Arginine; Biphenyl Compounds; Dose-Response Relationship, Drug; Heart Rate; Hemodynamics; Imidazoles; Infusions, Intravenous; Losartan; Male; Neuropeptides; Neurotransmitter Agents; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pituitary Adenylate Cyclase-Activating Polypeptide; Propanolamines; Rats; Regional Blood Flow; Sodium Chloride; Tetrazoles; Vasoactive Intestinal Peptide | 1994 |
Angiotensin II: endothelium-derived nitric oxide interaction in conscious rats.
Topics: Angiotensin II; Animals; Arginine; Biphenyl Compounds; Diet, Sodium-Restricted; Endothelium, Vascular; Hemodynamics; Imidazoles; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Sprague-Dawley; Renal Circulation; Renin; Tetrazoles | 1994 |
Altered renal vascular responses in the aging rat kidney.
Topics: Aging; Angiotensin II; Animals; Arginine; Biphenyl Compounds; Blood Pressure; Endothelins; Glomerular Filtration Rate; Imidazoles; Kidney; Losartan; Male; NG-Nitroarginine Methyl Ester; Rats; Rats, Sprague-Dawley; Renal Circulation; Tetrazoles | 1994 |
Angiotensin II 1 receptor-mediated contraction of pulmonary artery and its modulation by prolylcarboxypeptidase.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Arginine; Biphenyl Compounds; Carboxypeptidases; Dogs; Endothelium, Vascular; Imidazoles; In Vitro Techniques; Isometric Contraction; Losartan; Male; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Protease Inhibitors; Pulmonary Artery; Pyridines; Receptors, Angiotensin; Tetrazoles | 1994 |
Renin-angiotensin system in the pressor effect of acute N-omega-nitro-L-arginine methyl ester.
Topics: Animals; Arginine; Biphenyl Compounds; Blood Pressure; Desoxycorticosterone; Enalapril; Heart Rate; Imidazoles; Losartan; Male; Nephrectomy; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Wistar; Renin-Angiotensin System; Tetrazoles | 1993 |
Angiotensin II and alpha 1-adrenergic tone in chronic nitric oxide blockade-induced hypertension.
Topics: Administration, Oral; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Arginine; Biphenyl Compounds; Blood Pressure; Glomerular Filtration Rate; Hematocrit; Hypertension; Imidazoles; Kidney; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Prazosin; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1; Receptors, Angiotensin; Reference Values; Regional Blood Flow; Renal Circulation; Tetrazoles; Vascular Resistance | 1994 |
Vascular responsiveness to nitric oxide synthesis inhibition in hypertensive rats.
Topics: Animals; Antihypertensive Agents; Aorta, Thoracic; Aortic Coarctation; Arginine; Biphenyl Compounds; Blood Pressure; Hypertension; Imidazoles; In Vitro Techniques; Losartan; Male; Methylene Blue; NG-Nitroarginine Methyl Ester; Nitric Oxide; Phenylephrine; Rats; Rats, Sprague-Dawley; Tetrazoles; Vasoconstriction | 1994 |
Interactions of adenosine A1 receptor-mediated renal vasoconstriction with endogenous nitric oxide and ANG II.
Topics: Adenine; Adenosine; Angiotensin II; Animals; Arginine; Arginine Vasopressin; Biphenyl Compounds; Blood Pressure; Dose-Response Relationship, Drug; Heart Rate; Imidazoles; Kidney; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Phenylephrine; Purinergic Antagonists; Rats; Rats, Sprague-Dawley; Receptors, Purinergic P1; Regional Blood Flow; Renal Circulation; Serotonin; Tetrazoles; Thromboxane A2; Vascular Resistance; Vasoconstriction | 1993 |
Angiotensin II: nitric oxide interaction and the distribution of blood flow.
Topics: Angiotensin II; Animals; Arginine; Biphenyl Compounds; Blood Circulation; Blood Pressure; Cardiac Output; Heart Rate; Hemodynamics; Imidazoles; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Sprague-Dawley; Tetrazoles; Vascular Resistance | 1993 |
Renal nitric oxide and angiotensin II interaction in renovascular hypertension.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Arginine; Biphenyl Compounds; Endothelium, Vascular; Hemodynamics; Hypertension, Renovascular; Imidazoles; Kidney; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Sprague-Dawley; Renal Circulation; Tetrazoles | 1993 |
Effect of selective angiotensin II receptor antagonism and angiotensin converting enzyme inhibition on the coronary vasculature in vivo. Intravascular two-dimensional and Doppler ultrasound studies.
Topics: Adenosine; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Arginine; Biphenyl Compounds; Blood Flow Velocity; Coronary Circulation; Coronary Vessels; Dogs; Enalaprilat; Female; Imidazoles; Losartan; Male; NG-Nitroarginine Methyl Ester; Rest; Tetrazoles; Ultrasonography; Vasodilation | 1993 |
Renal effects of acute endothelial-derived relaxing factor blockade are not mediated by angiotensin II.
Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Arginine; Biphenyl Compounds; Blood Pressure; Diuresis; Glomerular Filtration Rate; Imidazoles; Kidney; Losartan; Male; Natriuresis; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Sprague-Dawley; Renal Circulation; Tetrazoles; Time Factors | 1993 |
Sodium and angiotensin in hypertension induced by long-term nitric oxide blockade.
Topics: Angiotensin II; Animals; Arginine; Biphenyl Compounds; Diet, Sodium-Restricted; Electrolytes; Hemodynamics; Hypertension; Imidazoles; Losartan; Male; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide; Organ Size; Rats; Rats, Wistar; Renin-Angiotensin System; Tetrazoles; Time Factors | 1993 |
Nitric oxide and the depressor response to angiotensin blockade in hypertension.
Topics: Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Aortic Coarctation; Arginine; Biphenyl Compounds; Blood Pressure; Hypertension; Imidazoles; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Ramipril; Rats; Rats, Sprague-Dawley; Renin; Tetrazoles; Vasoconstrictor Agents | 1996 |
Effects of angiotensin II infusion and inhibition of nitric oxide synthase on the rat aorta.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Aorta; Arginine; Biphenyl Compounds; Cell Division; Dose-Response Relationship, Drug; Drug Interactions; Endothelium, Vascular; Enzyme Inhibitors; Imidazoles; Infusion Pumps, Implantable; Losartan; Macrophages; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Proliferating Cell Nuclear Antigen; Rats; Rats, Wistar; Tetrazoles | 1996 |
Role of ANG II in hypertension produced by chronic inhibition of nitric oxide synthase in conscious rats.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Enalapril; Hypertension; Imidazoles; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Reference Values; Tetrazoles; Time Factors | 1996 |
Involvement of nitric oxide, but not prostaglandins, in the vascular sympathoinhibitory effects of losartan in the pithed spontaneously hypertensive rat.
Topics: Animals; Antihypertensive Agents; Biphenyl Compounds; Cyclooxygenase Inhibitors; Decerebrate State; Diclofenac; Electric Stimulation; Enzyme Inhibitors; Hemodynamics; Hypertension; Imidazoles; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Prostaglandins; Rats; Rats, Inbred SHR; Regional Blood Flow; Spinal Cord; Sympatholytics; Tetrazoles | 1996 |
Angiotensin II-induced renal responses in anesthetized rabbits: effects of N omega-nitro-L-arginine methyl ester and losartan.
Topics: Angiotensin II; Animals; Biphenyl Compounds; Enzyme Inhibitors; Hemodynamics; Imidazoles; Kidney; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Rabbits; Receptors, Angiotensin; Tetrazoles; Vasoconstrictor Agents | 1996 |
Multiple prejunctional actions of angiotensin II on noradrenergic transmission in the caudal artery of the rat.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Arteries; Biphenyl Compounds; Enzyme Inhibitors; Imidazoles; In Vitro Techniques; Indomethacin; Losartan; Male; NG-Nitroarginine Methyl Ester; Norepinephrine; Pyridines; Rats; Rats, Sprague-Dawley; Tetrazoles; Vasoconstriction | 1996 |
Contribution of the renin-angiotensin system to short-term blood pressure variability during blockade of nitric oxide synthesis in the rat.
Topics: Animals; Biphenyl Compounds; Blood Pressure; Heart Rate; Imidazoles; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Wistar; Renin-Angiotensin System; Tetrazoles | 1996 |
[Contribution of the renin-angiotensin system to the variability of blood pressure in hypertensive rat after blockade of nitric oxide synthesis].
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Heart Rate; Hypertension; Imidazoles; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Wistar; Renin-Angiotensin System; Tetrazoles | 1996 |
Losartan reduces phenylephrine constrictor response in aortic rings from spontaneously hypertensive rats. Role of nitric oxide and angiotensin II type 2 receptors.
Topics: Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Aorta, Thoracic; Biphenyl Compounds; Dose-Response Relationship, Drug; Drug Interactions; Enzyme Inhibitors; Imidazoles; Losartan; Male; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Phenylephrine; Pyridines; Rats; Rats, Inbred SHR; Receptors, Angiotensin; Tetrazoles; Vasoconstriction | 1996 |
Inhibition of nitric oxide synthase causes cardiac phenotypic modulation in rat.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Blotting, Northern; Collagen; Contractile Proteins; DNA Probes; Enzyme Inhibitors; Gene Expression Regulation; Heart; Imidazoles; Losartan; Male; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Organ Size; Phenotype; Rats; Rats, Wistar; RNA; Tetrazoles | 1997 |
Interaction of nitric oxide and the renin angiotensin system in renal hypertensive rats.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Enzyme Inhibitors; Heart Rate; Hypertension, Renovascular; Imidazoles; In Vitro Techniques; Losartan; Male; Muscle Contraction; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Renin; Renin-Angiotensin System; Tetrazoles; Vasoconstrictor Agents | 1997 |
Endothelial dysfunction in spontaneously hypertensive rats: consequences of chronic treatment with losartan or captopril.
Topics: Acetylcholine; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Aorta, Thoracic; Biphenyl Compounds; Blood Pressure; Captopril; Endothelium, Vascular; Hypertension; Imidazoles; In Vitro Techniques; Losartan; Male; NG-Nitroarginine Methyl Ester; Rats; Rats, Inbred SHR; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Superoxide Dismutase; Tetrazoles; Vasoconstriction; Vasodilation | 1997 |
The subtype 2 (AT2) angiotensin receptor mediates renal production of nitric oxide in conscious rats.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Blood Pressure; Cyclic GMP; Enzyme Inhibitors; Extracellular Space; Female; Imidazoles; Indazoles; Kidney; Losartan; Microdialysis; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Renin-Angiotensin System; Sodium; Tetrazoles | 1997 |
Attenuation of epinephrine-induced dysrhythmias by bradykinin: role of nitric oxide and prostaglandins.
Topics: Adrenergic beta-Antagonists; Analysis of Variance; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Biphenyl Compounds; Blood Pressure; Bradykinin; Bradykinin Receptor Antagonists; Cyclooxygenase Inhibitors; Enzyme Inhibitors; Epinephrine; Heart Rate; Imidazoles; Indomethacin; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Prostaglandins; Rats; Rats, Sprague-Dawley; Tetrazoles | 1997 |
Effect of angiotensin II on corpus cavernosum smooth muscle in relation to nitric oxide environment: in vitro studies in canines.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Dogs; Electric Stimulation; Enzyme Inhibitors; Losartan; Male; Muscle Contraction; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Penis; Phenylephrine | 1997 |
AT2 receptor stimulation increases aortic cyclic GMP in SHRSP by a kinin-dependent mechanism.
Topics: Angiotensin II; Animals; Aorta; Blood Pressure; Bradykinin; Bradykinin Receptor Antagonists; Cerebrovascular Disorders; Cyclic GMP; Hypertension; Imidazoles; Losartan; Male; Minoxidil; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Pyridines; Rats; Rats, Inbred SHR; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Reference Values | 1998 |
Angiotensin II stimulates the production of NO and peroxynitrite in endothelial cells.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Aorta, Thoracic; Arginine; Bradykinin; Calcium; Calmodulin; Cells, Cultured; Endothelium, Vascular; Losartan; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Oxidants; Rats; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Sulfonamides | 1998 |
Influence of nitric oxide in the chronic phase of two-kidney, one clip renovascular hypertension.
Topics: Animals; Antihypertensive Agents; Chronic Disease; Enzyme Inhibitors; Hemodynamics; Hypertension, Renovascular; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Renal Circulation | 1998 |
Losartan reduces constrictor responses to endothelin-1 and the thromboxane A2 analogue in aortic rings from spontaneously hypertensive rats: role of nitric oxide.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Animals; Antihypertensive Agents; Aorta, Thoracic; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelin-1; Enzyme Inhibitors; Hypertension; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Inbred SHR; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Thromboxane A2; Vasoconstriction; Vasoconstrictor Agents | 1997 |
Angiotensin II-nitric oxide interaction on sympathetic outflow in conscious rabbits.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Blood Pressure; Consciousness; Kidney; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Phenylephrine; Rabbits; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Sympathetic Nervous System | 1998 |
Brain ANG II and prostaglandins mediate the pressor response after central blockade of nitric oxide synthase.
Topics: Animals; Arginine; Blood Pressure; Cerebral Ventricles; Dose-Response Relationship, Drug; Heart Rate; Indomethacin; Injections, Intravenous; Injections, Intraventricular; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Prazosin; Rats; Rats, Sprague-Dawley | 1998 |
Sympathetic functions in NG-nitro-L-arginine-methyl-ester-induced hypertension: modulation by the renin-angiotensin system.
Topics: Adenylyl Cyclases; Animals; Antihypertensive Agents; Enalaprilat; Enzyme Inhibitors; Epinephrine; GTP-Binding Proteins; Heart; Hemodynamics; Hypertension; In Vitro Techniques; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Norepinephrine; Organ Size; Rats; Rats, Sprague-Dawley; Receptors, Adrenergic, beta; Renin-Angiotensin System; Sympathetic Nervous System | 1998 |
Accelerated apoptosis characterizes cyclosporine-associated interstitial fibrosis.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Apoptosis; Arginine; Biotin; Cyclosporine; Deoxyuracil Nucleotides; DNA Fragmentation; Enzyme Inhibitors; Fibrosis; Hydralazine; Immunosuppressive Agents; Ischemia; Kidney; Losartan; Macrophages; Male; Nephritis, Interstitial; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Staining and Labeling | 1998 |
Hemodynamic effect of 17 beta-estradiol in absence of NO in ovariectomized rats: role of angiotensin II.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Cardiac Output; Enzyme Inhibitors; Estradiol; Female; Hemodynamics; Losartan; NG-Nitroarginine Methyl Ester; Nitric Oxide; Ovariectomy; Rats; Rats, Sprague-Dawley; Vascular Resistance | 1998 |
Role of AT1 receptors in the renal papillary effects of acute and chronic nitric oxide inhibition.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Blood Pressure; Enzyme Inhibitors; Kidney Medulla; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Rats; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Regional Blood Flow | 1998 |
Evidence that angiotensin II, endothelins and nitric oxide regulate mitogen-activated protein kinase activity in rat aorta.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Aorta; Calcium-Calmodulin-Dependent Protein Kinases; Endothelin Receptor Antagonists; Endothelins; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitroprusside; Peptides, Cyclic; Rats; Rats, Wistar | 1998 |
[Renal alterations in L-NAME hypertension: influence of losartan and bosentan].
Topics: Albuminuria; Animals; Antihypertensive Agents; Bosentan; Endothelin Receptor Antagonists; Enzyme Inhibitors; Hemodynamics; Hypertension; Kidney; Kidney Function Tests; Losartan; Male; NG-Nitroarginine Methyl Ester; Rats; Rats, Wistar; Sulfonamides | 1998 |
Factors involved in the effects of losartan on endothelial dysfunction induced by aging in SHR.
Topics: Acetylcholine; Aging; Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Kidney; Losartan; Male; Mesenteric Arteries; NG-Nitroarginine Methyl Ester; Nitrites; Phenylephrine; Potassium Chloride; Rats; Rats, Inbred SHR; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Vasoconstrictor Agents; Vasodilation | 1998 |
Alpha1-adrenergic plus angiotensin receptor blockade reduces atherosclerosis in apolipoprotein E-deficient mice.
Topics: Adrenergic alpha-Antagonists; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Apolipoproteins E; Arteriosclerosis; Blood Pressure; Drug Therapy, Combination; Hypercholesterolemia; Losartan; Mice; Mice, Inbred C57BL; NG-Nitroarginine Methyl Ester; Prazosin; Propranolol; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Time Factors | 1998 |
Guinea pig airway hyperresponsiveness induced by blockade of the angiotensin II type 1 receptor. Role for endogenous nitric oxide.
Topics: Acetylcholine; Airway Obstruction; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Bronchi; Bronchial Hyperreactivity; Bronchoconstriction; Cells, Cultured; Enzyme Inhibitors; Epithelial Cells; Guinea Pigs; Imidazoles; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Pyridines | 1999 |
Pressor and renal vasoconstrictor responses to acute systemic nitric oxide synthesis inhibition are independent of the sympathetic nervous system and angiotensin II.
Topics: Adrenergic alpha-Antagonists; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Blood Pressure; Enzyme Inhibitors; Kidney; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Prazosin; Pressoreceptors; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Renal Circulation; Sympathetic Nervous System; Vasoconstriction | 1999 |
Role of NO and angiotensin II in the early development of endothelial functions impairment and cardiac hypertrophy in deoxycorticosterone acetate-salt hypertension.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Cardiomegaly; Desoxycorticosterone; Endothelium, Vascular; Hypertension; In Vitro Techniques; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Organ Size; Rats; Rats, Sprague-Dawley; Sodium Chloride; Splanchnic Circulation | 1998 |
Telemetry for cardiovascular monitoring in a pharmacological study: new approaches to data analysis.
Topics: Animals; Antihypertensive Agents; Aorta; Blood Pressure; Cardiomegaly; Cell Nucleus; Diastole; DNA; Female; Heart Rate; Humans; Hydralazine; Hydrochlorothiazide; Hypertension; Indoles; Losartan; Lymphocytes; Male; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Perindopril; Rats; Rats, Inbred SHR; Systole; Telemetry; Time Factors | 1999 |
Angiotensin II-stimulated nitric oxide release from porcine pulmonary endothelium is mediated by angiotensin IV.
Topics: Angiotensin II; Animals; Bradykinin; Cells, Cultured; Dose-Response Relationship, Drug; Drug Interactions; Endothelium, Vascular; Enzyme Activation; Enzyme Inhibitors; Losartan; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Pulmonary Artery; Reference Values; Swine; Vasoconstrictor Agents | 1999 |
Losartan and enalapril therapies enhance vasodilatation in the mesenteric artery of spontaneously hypertensive rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Body Weight; Diclofenac; Enalapril; Endothelium; Enzyme Inhibitors; Heart Rate; Hypertension; In Vitro Techniques; Losartan; Male; Mesenteric Arteries; Muscle Contraction; Muscle Relaxation; NG-Nitroarginine Methyl Ester; Potassium Chloride; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Vasoconstrictor Agents; Vasodilation | 1999 |
Role of angiotensin II in modulating the hemodynamic effects of nitric oxide synthesis inhibition.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Capillary Permeability; Enzyme Inhibitors; Extravasation of Diagnostic and Therapeutic Materials; Female; Hemodynamics; Laser-Doppler Flowmetry; Losartan; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Sprague-Dawley | 1999 |
Interactions between angiotensin II and nitric oxide during exercise in normal and heart failure rats.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Blood Pressure; Female; Heart Diseases; Heart Rate; Losartan; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Physical Conditioning, Animal; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Regional Blood Flow | 1999 |
Functional evidence for an angiotensin IV receptor in rat resistance arteries.
Topics: Animals; Benzimidazoles; Biphenyl Compounds; Drug Interactions; Imidazoles; In Vitro Techniques; Indomethacin; Losartan; Male; Mesenteric Arteries; NG-Nitroarginine Methyl Ester; Perfusion; Phenylephrine; Pyridines; Rats; Rats, Wistar; Receptors, Angiotensin; Serotonin; Tachyphylaxis; Tetrazoles; Vascular Resistance | 1999 |
Arterial function in nitric oxide-deficient hypertension: influence of long-term angiotensin II receptor antagonism.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Cromakalim; Cyclooxygenase Inhibitors; Diclofenac; Hypertension; In Vitro Techniques; Isoproterenol; Losartan; Male; Mesenteric Arteries; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitroprusside; Rats; Rats, Wistar; Vasodilator Agents | 1999 |
Renal and vascular effects of chronic nitric oxide synthase inhibition: involvement of endothelin 1 and angiotensin II.
Topics: Angiotensin II; Animals; Blood Pressure; Endothelin-1; Enzyme Inhibitors; Kidney; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley | 1999 |
Angiotensin II activates collagen type I gene in the renal vasculature of transgenic mice during inhibition of nitric oxide synthesis: evidence for an endothelin-mediated mechanism.
Topics: Angiotensin Receptor Antagonists; Animals; Collagen; Endothelins; Enzyme Inhibitors; Gene Expression Regulation; Kidney; Losartan; Male; Mice; Mice, Transgenic; NG-Nitroarginine Methyl Ester; Nitric Oxide; Promoter Regions, Genetic; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin | 1999 |
Blood pressure variability in established L-NAME hypertension in rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Enzyme Inhibitors; Hypertension; Losartan; Male; NG-Nitroarginine Methyl Ester; Prazosin; Rats; Rats, Wistar; Time Factors | 1999 |
Angiotensin AT(2) receptors mediate vasodepressor response to footshock in rats. Role of kinins, nitric oxide and prostaglandins.
Topics: Animals; Blood Pressure; Bradykinin; Electroshock; Heart Rate; Imidazoles; Kinins; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Prostaglandins; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin | 2000 |
Angiotensin II induces contraction and proliferation of human hepatic stellate cells.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Cell Division; Cell Size; Cells, Cultured; Cyclooxygenase Inhibitors; Dinoprostone; Enzyme Inhibitors; Humans; Imidazoles; Indomethacin; Iodine Radioisotopes; Liver; Losartan; Mitogen-Activated Protein Kinases; NG-Nitroarginine Methyl Ester; Nitric Oxide Donors; Penicillamine; Pyridines; Radioligand Assay; Rats; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Sodium Nitrite; Thymidine; Vasoconstrictor Agents | 2000 |
Role of bradykinins and nitric oxide in the AT2 receptor-mediated hypotension.
Topics: Adrenergic beta-Antagonists; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Blood Pressure; Bradykinin; Bradykinin Receptor Antagonists; Drug Administration Routes; Enzyme Inhibitors; Hot Temperature; Hypertension; Hypotension; Imidazoles; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Shock; Vasodilation | 2000 |
Indomethacin prevents the L-NAME-induced increase in plasma levels of oxytocin in dehydrated rats.
Topics: Angiotensin II; Animals; Dehydration; Hypothalamo-Hypophyseal System; Indomethacin; Injections, Intraventricular; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Oxytocin; Prostaglandins; Rats; Rats, Sprague-Dawley; Vasopressins; Water Deprivation; Water-Electrolyte Balance | 2000 |
H+-ATPase activity on unilateral ureteral obstruction: interaction of endogenous nitric oxide and angiotensin II.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Enzyme Activation; Enzyme Inhibitors; Female; Kidney Medulla; Losartan; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitrites; Proton-Translocating ATPases; Rats; Rats, Inbred WKY; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Renal Circulation; Ureteral Obstruction | 2000 |
Deoxycorticosterone suppresses the effects of losartan in nitric oxide-deficient hypertensive rats.
Topics: Albuminuria; Animals; Blood Pressure; Blood Proteins; Creatinine; Desoxycorticosterone; Enzyme Inhibitors; Hypertension; Kidney; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Wistar; Renin; Sodium, Dietary | 2000 |
Losartan inhibits the adhesion of rat platelets to fibrillar collagen--a potential role of nitric oxide and prostanoids.
Topics: Animals; Antihypertensive Agents; Collagen; Cyclooxygenase Inhibitors; Dose-Response Relationship, Drug; Enzyme Inhibitors; In Vitro Techniques; Indomethacin; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Platelet Adhesiveness; Prostaglandins; Rats; Rats, Wistar | 2000 |
Role of the central nervous system in the development of hypertension produced by chronic nitric oxide blockade in rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Body Weight; Central Nervous System; Enzyme Inhibitors; gamma-Aminobutyric Acid; Hypertension; Losartan; Male; Microelectrodes; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Rats; Rats, Wistar; Renin-Angiotensin System | 2001 |
Comparative studies on the memory-enhancing actions of captopril and losartan in mice using inhibitory shock avoidance paradigm.
Topics: Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Antihypertensive Agents; Avoidance Learning; Captopril; Dizocilpine Maleate; Electroshock; Enzyme Inhibitors; Losartan; Male; Memory; Mice; Mice, Inbred Strains; Muscarinic Antagonists; Neuroprotective Agents; NG-Nitroarginine Methyl Ester; Reaction Time; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Scopolamine | 2001 |
Differential subcellular actions of ACE inhibitors and AT(1) receptor antagonists on cardiac remodeling induced by chronic inhibition of NO synthesis in rats.
Topics: Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Body Weight; Cardiomegaly; Coronary Vessels; Enalapril; Enzyme Inhibitors; Heart Rate; Heart Ventricles; Imidazoles; Losartan; Male; Mitogen-Activated Protein Kinases; Myocardium; Neutrophil Infiltration; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Olmesartan Medoxomil; Organ Size; Rats; Rats, Inbred WKY; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Ribosomal Protein S6 Kinases; Tetrazoles; Thiazepines | 2001 |
Angiotensin II type AT(2) receptor mRNA expression and renal vasodilatation are increased in renal failure.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 5,8,11,14-Eicosatetraynoic Acid; Angiotensin II; Animals; Antihypertensive Agents; Arachidonic Acid; Clotrimazole; Cytochrome P-450 Enzyme System; Dose-Response Relationship, Drug; Gene Expression Regulation; Imidazoles; In Vitro Techniques; Indomethacin; Kidney; Losartan; Male; NG-Nitroarginine Methyl Ester; Oligopeptides; Pyridines; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Renal Insufficiency; RNA, Messenger; Vasodilation | 2001 |
Angiotensin type 2 receptor-mediated hypotension in angiotensin type-1 receptor-blocked rats.
Topics: Angiotensin Receptor Antagonists; Animals; Blood Pressure Determination; Diet, Sodium-Restricted; Hypotension; Losartan; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Oligopeptides; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin; Tetrazoles; Valine; Valsartan; Vasodilation | 2001 |
Effects of angiotensin blockade in the rostral ventrolateral medulla on maintenance of hypertension induced by chronic L-NAME treatment.
Topics: Administration, Oral; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Enzyme Inhibitors; Glycine; Hypertension; Injections, Intraventricular; Losartan; Male; Medulla Oblongata; Microinjections; NG-Nitroarginine Methyl Ester; Rats; Rats, Wistar; Receptors, Angiotensin | 2002 |
Altered balance of main vasopressor and vasodepressor systems in rats with genetic hypertension and hypertriglyceridaemia.
Topics: Analysis of Variance; Animals; Cyclic N-Oxides; Enzyme Inhibitors; Female; Hypertension; Hypertriglyceridemia; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Pentolinium Tartrate; Rats; Rats, Inbred Lew; Rats, Wistar; Renin-Angiotensin System; Sex Factors; Spin Labels; Superoxides; Sympathetic Nervous System | 2002 |
Nitric oxide mediates inhibitory effect of losartan on angiotensin-induced contractions in hamster but not rat aorta.
Topics: Angiotensins; Animals; Aorta; Cricetinae; Enzyme Inhibitors; In Vitro Techniques; Losartan; Male; Mesocricetus; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Species Specificity; Vasoconstriction | 2000 |
Effect of 1-week losartan administration on bile duct-ligated cirrhotic rats with portal hypertension.
Topics: Angiotensin II; Animals; Antihypertensive Agents; Blotting, Western; Common Bile Duct; Enzyme Inhibitors; Hematocrit; Hypertension, Portal; Ligation; Liver Circulation; Liver Cirrhosis; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Norepinephrine; Plasma Volume; Rats; Rats, Sprague-Dawley; Renin | 2002 |
Effect of exogenous and endogenous angiotensin II on intrarenal distribution of glomerular filtration rate in rats.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Aprotinin; Glomerular Filtration Rate; Hemostatics; Juxtaglomerular Apparatus; Kidney; Kidney Cortex; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Renal Circulation; Vascular Resistance | 2002 |
Effects of losartan on the blood-brain barrier permeability in long-term nitric oxide blockade-induced hypertensive rats.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Blood Pressure; Blood-Brain Barrier; Coloring Agents; Enzyme Inhibitors; Evans Blue; Hypertension; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Rats; Rats, Wistar | 2002 |
N(G)-nitro-L-arginine methyl ester-induced hypertension and natriuretic peptide gene expression: inhibition by angiotensin II type 1 receptor antagonism.
Topics: Angiotensin Receptor Antagonists; Animals; Atrial Natriuretic Factor; Enzyme Inhibitors; Gene Expression Regulation; Hypertension; In Vitro Techniques; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptors, Angiotensin | 2002 |
Cross-talk between AT(1) and AT(2) angiotensin receptors in rat anococcygeus smooth muscle.
Topics: Angiotensin II; Animals; Imidazoles; Kinetics; Losartan; Male; Muscle Contraction; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Prazosin; Pyridines; Rats; Rats, Wistar; Receptor Cross-Talk; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin | 2002 |
Angiotensin II AT1 receptor antagonists inhibit platelet adhesion and aggregation by nitric oxide release.
Topics: Angiotensin Receptor Antagonists; Blood Platelets; Cells, Cultured; Dose-Response Relationship, Drug; Endothelium, Vascular; Enzyme Inhibitors; Imidazoles; Kinetics; Losartan; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Platelet Adhesiveness; Platelet Aggregation; Platelet Aggregation Inhibitors; Receptor, Angiotensin, Type 1; Tetrazoles; Valine; Valsartan | 2002 |
Resolving the composite trait of hypertension into its pharmacogenetic determinants by acute pharmacological modulation of blood pressure regulatory systems.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Enzyme Inhibitors; Hypertension; Lod Score; Losartan; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pentolinium Tartrate; Quantitative Trait Loci; Quantitative Trait, Heritable; Rats; Rats, Wistar; Renin-Angiotensin System; Sympathetic Nervous System | 2003 |
Angiotensin II subtype AT1 receptor blockade prevents hypertension and renal insufficiency induced by chronic NO-synthase inhibition in rats.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Biphenyl Compounds; Glomerular Filtration Rate; Heart; Hypertension; Imidazoles; Kidney; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Rats; Rats, Wistar; Renal Insufficiency; Ventricular Fibrillation | 2003 |
Vasopeptidase inhibitor omapatrilat induces profound insulin sensitization and increases myocardial glucose uptake in Zucker fatty rats: Studies comparing a vasopeptidase inhibitor, angiotensin-converting enzyme inhibitor, and angiotensin II type I recept
Topics: Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Animals; Biological Transport; Blood Glucose; Bradykinin; Bradykinin Receptor Antagonists; Drug Synergism; Enzyme Inhibitors; Glucose; Glucose Clamp Technique; Insulin; Insulin Resistance; Losartan; Male; Myocardium; Neprilysin; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Protease Inhibitors; Pyridines; Ramipril; Rats; Rats, Zucker; Receptor, Angiotensin, Type 1; Receptor, Bradykinin B2; Thiazepines | 2003 |
Effect of angiotensin AT2 receptor stimulation on vascular cyclic GMP production in normotensive Wistar Kyoto rats.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Aorta; Blood Pressure; Cyclic GMP; Endothelium, Vascular; Enzyme Inhibitors; Imidazoles; Losartan; Male; Minoxidil; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Pyridines; Rats; Rats, Inbred WKY; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, Angiotensin | 2003 |
The vascular response to the K+ channel inhibitor 4-aminopyridine in hypertensive rats.
Topics: 4-Aminopyridine; Adrenalectomy; Adrenergic Antagonists; Amifampridine; Angiotensin Receptor Antagonists; Animals; Blood Pressure; Endothelin Receptor Antagonists; Enzyme Inhibitors; Hypertension; In Vitro Techniques; Indomethacin; Losartan; Male; Muscarinic Antagonists; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Phentolamine; Potassium Channel Blockers; Prazosin; Protein Kinase C; Pyrazines; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptor, Angiotensin, Type 1; Receptor, Endothelin A; Staurosporine; Sulfonamides; Vascular Resistance; Vasoconstriction | 2003 |
Increased pressor sensitivity to chronic nitric oxide deficiency in hyperthyroid rats.
Topics: Angiotensin II; Animals; Blood Pressure; Creatinine; Enzyme Inhibitors; Heart Rate; Hyperthyroidism; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide; Nitric Oxide Synthase; Nitrites; Potassium; Proteinuria; Rats; Rats, Wistar; Sodium; Thyroxine | 2003 |
Effect of losartan on renal microvasculature during chronic inhibition of nitric oxide visualized by micro-CT.
Topics: Angiography; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Blood Vessels; Enzyme Inhibitors; Kidney; Losartan; Male; Microcirculation; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Sprague-Dawley; Renal Circulation; Tomography, X-Ray Computed | 2003 |
Role of prostaglandin, endothelin and sympathetic nervous system on the L-NAME-induced pressor responses in spontaneously hypertensive rats.
Topics: Acetamides; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Chlorisondamine; Cyclooxygenase Inhibitors; Endothelin Receptor Antagonists; Endothelins; Enzyme Inhibitors; Ganglionic Blockers; Heart Rate; Indomethacin; Injections, Intraventricular; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Oligopeptides; Prostaglandins; Rats; Rats, Inbred SHR; Sympathetic Nervous System | 2003 |
Facilitation of renal autoregulation by angiotensin II is mediated through modulation of nitric oxide.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Cyclic N-Oxides; Endothelium-Dependent Relaxing Factors; Erythrocytes; Glomerular Filtration Rate; Homeostasis; Indomethacin; Kidney; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Perfusion; Phenylephrine; Prostaglandin-Endoperoxide Synthases; Rats; Rats, Sprague-Dawley; Spin Labels; Vasoconstriction | 2003 |
The receptors and role of angiotensin II in knee joint blood flow regulation and role of nitric oxide in modulation of their function.
Topics: Angiotensin II; Animals; Knee Joint; Losartan; Microcirculation; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rabbits; Receptor, Angiotensin, Type 1; Vascular Resistance; Vasoconstriction | 2003 |
Effect of losartan on the blood-brain barrier permeability in diabetic hypertensive rats.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Blood-Brain Barrier; Diabetes Mellitus, Experimental; Epinephrine; Evans Blue; Hypertension; Losartan; Male; NG-Nitroarginine Methyl Ester; Permeability; Rats; Rats, Wistar | 2003 |
Prostacyclin and thromboxane A2 production in nitric oxide-deficient hypertension in vivo. Effects of high calcium diet and angiotensin receptor blockade.
Topics: Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Calcium, Dietary; Enzyme Inhibitors; Epoprostenol; Hypertension; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Wistar; Receptors, Angiotensin; Thromboxane A2 | 2003 |
Relative roles of nitric oxide, prostanoids and angiotensin II in the regulation of canine glomerular hemodynamics. A micropuncture study.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Cyclooxygenase Inhibitors; Dogs; Enzyme Inhibitors; Female; Glomerular Filtration Rate; Hemodynamics; Imidazoles; Indomethacin; Kidney Glomerulus; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Prostaglandins; Renal Circulation; Tetrazoles; Time Factors | 2004 |
Gender-specific genetic determinants of blood pressure and organ weight: pharmacogenetic approach.
Topics: Animals; Blood Pressure; Body Weight; Chromosomes, Mammalian; Crosses, Genetic; Disease Models, Animal; Female; Genotype; Heart; Hypertension; Kidney; Lod Score; Losartan; Male; Microvascular Angina; Multifactorial Inheritance; NG-Nitroarginine Methyl Ester; Organ Size; Pentolinium Tartrate; Pharmacogenetics; Phenotype; Polymorphism, Genetic; Quantitative Trait Loci; Rats; Rats, Inbred Lew; Rats, Wistar; Sex Factors | 2003 |
Cardiovascular and renal phenotype in mice with one or two renin genes.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Blood Pressure; Enzyme Inhibitors; Losartan; Male; Mice; Mice, Inbred C57BL; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Phenotype; Renal Circulation; Renin | 2004 |
Chronic AT(1) receptor blockade alters mechanisms mediating responses to hypoxia in rat skeletal muscle resistance arteries.
Topics: Acetylcholine; Angiotensin II Type 1 Receptor Blockers; Animals; Arteries; Cardiovascular Agents; Enzyme Inhibitors; Epoprostenol; Hypoxia; In Vitro Techniques; Indomethacin; Losartan; Male; Muscle, Skeletal; NG-Nitroarginine Methyl Ester; Oxygen; Partial Pressure; Rats; Rats, Sprague-Dawley; Receptors, Thromboxane A2, Prostaglandin H2; Thromboxane A2; Thromboxanes; Time Factors; Vascular Resistance; Vasoconstriction; Vasodilation; Vasodilator Agents | 2004 |
Losartan-induced attenuation of blood pressure in L-NAME hypertensive rats is associated with reversal of the enhanced expression of Gi alpha proteins.
Topics: Adenylyl Cyclases; Animals; Antihypertensive Agents; Blood Pressure; Colforsin; Disease Models, Animal; Enzyme Inhibitors; GTP-Binding Protein alpha Subunit, Gi2; GTP-Binding Protein alpha Subunits, Gi-Go; Guanosine 5'-O-(3-Thiotriphosphate); Hypertension; Losartan; Male; Models, Cardiovascular; NG-Nitroarginine Methyl Ester; Proto-Oncogene Proteins; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley; RNA, Messenger; Sodium Fluoride; Statistics as Topic | 2004 |
Angiotensin II-induced relaxation of anococcygeus smooth muscle via desensitization of AT1 receptor, and activation of AT2 receptor associated with nitric-oxide synthase pathway.
Topics: Adenine; Angiotensin II; Animals; Blotting, Western; CD13 Antigens; Drug Interactions; Glutamyl Aminopeptidase; Imidazoles; Losartan; Male; Muscle Contraction; Muscle Relaxation; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Peptide Fragments; Peptides; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Tetrodotoxin; Thiorphan | 2004 |
Intrarenal Renin-Angiotensin system is upregulated in experimental model of progressive renal disease induced by chronic inhibition of nitric oxide synthesis.
Topics: Albumins; Angiotensin-Converting Enzyme Inhibitors; Angiotensinogen; Angiotensins; Animals; Antihypertensive Agents; Blood Pressure; Blotting, Western; Cathepsin D; Enalapril; Enzyme Inhibitors; Glomerulonephritis; Immunohistochemistry; Kidney; Kidney Diseases; Losartan; Male; Mycophenolic Acid; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Wistar; Renin; Renin-Angiotensin System; Time Factors; Up-Regulation | 2004 |
Ouabain-induced hypertension alters the participation of endothelial factors in alpha-adrenergic responses differently in rat resistance and conductance mesenteric arteries.
Topics: Animals; Antihypertensive Agents; Blotting, Western; Cardiotonic Agents; Cyclooxygenase Inhibitors; Endothelium, Vascular; Enzyme Inhibitors; Hypertension; In Vitro Techniques; Losartan; Male; Mesenteric Arteries; Mesenteric Artery, Superior; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Norepinephrine; Ouabain; Phenylephrine; Potassium Chloride; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptors, Adrenergic, alpha; Vascular Resistance; Vasoconstrictor Agents | 2004 |
Regional hemodynamic actions of selective corticotropin-releasing factor type 2 receptor ligands in conscious rats.
Topics: Animals; Corticotropin-Releasing Hormone; Drug Interactions; Hemodynamics; Indans; Indomethacin; Losartan; Male; NG-Nitroarginine Methyl Ester; Rats; Rats, Sprague-Dawley; Receptors, Corticotropin-Releasing Hormone; Urocortins | 2005 |
Bolus injection of human UII in conscious rats evokes a biphasic haemodynamic response.
Topics: Amidines; Animals; Arginine; Arginine Vasopressin; Benzylamines; Blood Pressure; Cardiovascular Physiological Phenomena; Cardiovascular System; Consciousness; Enzyme Inhibitors; Heart Rate; Hemodynamics; Humans; Indans; Indomethacin; Injections, Intravenous; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Propranolol; Rats; Rats, Inbred F344; Rats, Inbred Lew; Rats, Inbred SHR; Rats, Inbred WKY; Rats, Sprague-Dawley; Urotensins; Vasoconstriction; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents | 2004 |
Interaction of central Ang II and NO on the cardiac sympathetic afferent reflex in dogs.
Topics: Afferent Pathways; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Blood Pressure; Citrulline; Dogs; Dose-Response Relationship, Drug; Dose-Response Relationship, Radiation; Drug Administration Routes; Drug Interactions; Electric Stimulation; Enzyme Inhibitors; Female; Heart; Heart Rate; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Reflex; Sympathectomy; Sympathetic Nervous System; Thiourea; Time Factors; Vagotomy | 2005 |
Superiority of combination of thiazide with angiotensin-converting enzyme inhibitor or AT1-receptor blocker over thiazide alone on renoprotection in L-NAME/SHR.
Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Body Weight; Diuretics; Enalapril; Enzyme Inhibitors; Hematocrit; Hemodynamics; Hydrochlorothiazide; Kidney; Kidney Diseases; Kidney Glomerulus; Losartan; Male; NG-Nitroarginine Methyl Ester; Organ Size; Rats; Rats, Inbred SHR; Renal Circulation; Vascular Resistance | 2005 |
Angiotensin-converting enzyme inhibition and angiotensin AT1-receptor antagonism equally improve endothelial vasodilator function in L-NAME-induced hypertensive rats.
Topics: 6-Ketoprostaglandin F1 alpha; Acetylcholine; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Aorta, Thoracic; Blood Pressure; Bradykinin; Bradykinin Receptor Antagonists; Enalapril; Endothelium, Vascular; Enzyme Inhibitors; Hypertension; In Vitro Techniques; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide Synthase; Nitric Oxide Synthase Type III; Nitrites; Norepinephrine; Peptidyl-Dipeptidase A; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger; Systole; Vasoconstriction; Vasodilation; Vasodilator Agents | 2005 |
Effects of losartan on blood pressure, oxidative stress, and nitrate/nitrite levels in the nitric oxide deficient hypertensive rats.
Topics: Analysis of Variance; Animals; Antihypertensive Agents; Antioxidants; Blood Pressure; Body Weight; Creatinine; Dose-Response Relationship, Drug; Heart; Hypertension; Kidney; Lipid Peroxidation; Losartan; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide; Nitrites; Organ Size; Oxidative Stress; Peptidyl-Dipeptidase A; Rats; Rats, Wistar; Time Factors | 2004 |
Evidence for a functional interaction of the angiotensin-(1-7) receptor Mas with AT1 and AT2 receptors in the mouse heart.
Topics: Angiotensin I; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Drug Synergism; Enzyme Inhibitors; Imidazoles; In Vitro Techniques; Indomethacin; Losartan; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocardium; NG-Nitroarginine Methyl Ester; Peptide Fragments; Perfusion; Pressure; Proto-Oncogene Mas; Proto-Oncogene Proteins; Pyridines; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Receptors, G-Protein-Coupled; Vasoconstrictor Agents | 2005 |
Angiotensin II type 1 receptor antagonism improves endothelial vasodilator function in L-NAME-induced hypertensive rats by a kinin-dependent mechanism.
Topics: 6-Ketoprostaglandin F1 alpha; Acetylcholine; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Bradykinin; Bradykinin B2 Receptor Antagonists; Endothelium, Vascular; Gene Expression Regulation, Enzymologic; Hypertension; Kinins; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitrates; Nitric Oxide Synthase Type III; Nitrites; Nitroprusside; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1; Receptor, Bradykinin B2; RNA, Messenger; Vasodilation | 2006 |
Enhanced AT1 receptor-mediated vasocontractile response to ANG II in endothelium-denuded aorta of obese Zucker rats.
Topics: Acetylcholine; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Aorta, Thoracic; Body Weight; Endothelial Cells; Endothelin-1; Enzyme Inhibitors; In Vitro Techniques; Losartan; Male; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type III; Nitroprusside; Obesity; Potassium Chloride; Rats; Rats, Zucker; Receptor, Angiotensin, Type 1; RNA, Messenger; Vasoconstriction; Vasoconstrictor Agents; Vasodilator Agents | 2007 |
Hepatic morphological alterations, glycogen content and cytochrome P450 activities in rats treated chronically with N(omega)-nitro-L-arginine methyl ester (L-NAME).
Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Chronic Disease; Cytochrome P-450 Enzyme System; Enalapril; Enzyme Activation; Enzyme Inhibitors; Fasting; Glucose; Glycogen; Glycogen Synthase Kinase 3; Hypertension; Hypertrophy; Liver; Liver Cirrhosis; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Peptidyl-Dipeptidase A; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Rats, Wistar; Renin-Angiotensin System | 2007 |
Bosentan and losartan ameliorate acute renal failure associated with mild but not strong NO blockade.
Topics: Acute Kidney Injury; Animals; Antihypertensive Agents; Blood Pressure; Bosentan; Cardiac Output; Heart Rate; Infusions, Intravenous; Kidney; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Wistar; Regional Blood Flow; Sulfonamides; Vascular Resistance | 2007 |
Angiotensin-(1-7) blocks the angiotensin II-stimulated superoxide production.
Topics: Acetophenones; Allopurinol; Angiotensin I; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Aorta, Thoracic; Drug Antagonism; Enzyme Inhibitors; Imidazoles; In Vitro Techniques; Indomethacin; Losartan; Male; NADH, NADPH Oxidoreductases; NG-Nitroarginine Methyl Ester; Onium Compounds; Peptide Fragments; Pyridines; Rats; Rats, Sprague-Dawley; Receptors, G-Protein-Coupled; Superoxides | 2007 |
Angiotensin II type 1 receptor blocker preserves tolerance to ischemia-reperfusion injury in Dahl salt-sensitive rat heart.
Topics: Aldehydes; Amidines; Angiotensin II Type 1 Receptor Blockers; Animals; Antioxidants; Benzylamines; Disease Models, Animal; Enzyme Activation; Enzyme Inhibitors; Hypertension; Losartan; Male; Malondialdehyde; Myocardial Infarction; Myocardial Reperfusion Injury; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oxidative Stress; Phosphorylation; Rats; Rats, Inbred Dahl; Sodium Chloride, Dietary; Tiopronin; Up-Regulation; Ventricular Function, Left | 2008 |
N-acetylcysteine abolishes the protective effect of losartan against left ventricular remodeling in cardiomyopathy hamster.
Topics: Acetylcysteine; Amidines; Angiotensin II Type 1 Receptor Blockers; Animals; Benzylamines; Cardiomyopathies; Cricetinae; Drug Interactions; Enzyme Inhibitors; Fibrosis; Free Radical Scavengers; Heart; Heart Ventricles; Losartan; Male; Myocardium; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Organ Size; Oxidative Stress; Phosphatidylinositol 3-Kinases; Phosphorylation; Proto-Oncogene Proteins c-akt; Ventricular Function, Left; Ventricular Remodeling | 2008 |
Angiotensin II type 2 receptor-mediated inhibition of norepinephrine release in isolated rat hearts.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin II Type 2 Receptor Blockers; Animals; Bradykinin; Heart; Imidazoles; In Vitro Techniques; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Norepinephrine; Oligopeptides; Phenylalanine; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Sympathetic Nervous System; Tranexamic Acid; Vasoconstrictor Agents | 2008 |
Angiotensin II-mediated vasodilation is reduced in adult spontaneously hypertensive rats despite enhanced expression of AT2 receptors.
Topics: Acetylcholine; Aging; Angiotensin II; Animals; Blotting, Western; Bradykinin; Gene Expression Regulation; Imidazoles; Losartan; Mesenteric Arteries; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Peptide Fragments; Pyridines; Rats; Rats, Inbred SHR; Receptor, Angiotensin, Type 2; Vasodilation | 2009 |
Protective effects of angiotensin AT1 receptor blockade in malignant hypertension in the rat.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Atrasentan; Blood Pressure; Endothelin-1; Hydralazine; Hypertension, Malignant; Losartan; Male; Necrosis; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Renal Insufficiency | 2009 |
Long-term metabolic effects of different doses of niacin-bound chromium on Sprague-Dawley rats.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Blood Chemical Analysis; Blood Glucose; Blood Pressure; Body Weight; Chromium; Diet; Dietary Supplements; Drinking; Eating; Enzyme Inhibitors; Female; Glucose Tolerance Test; Insulin; Losartan; Male; NG-Nitroarginine Methyl Ester; Niacin; Rats; Rats, Sprague-Dawley | 2010 |
Angiotensin II induces a region-specific hyperplasia of the ascending aorta through regulation of inhibitor of differentiation 3.
Topics: Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Aorta; Blood Pressure; Hyperplasia; Hypertension; Inhibitor of Differentiation Proteins; Losartan; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; NG-Nitroarginine Methyl Ester; Norepinephrine; Organ Specificity; Receptor, Angiotensin, Type 1; Renin; Tunica Media | 2010 |
Losartan increases NO release in afferent arterioles during regression of L-NAME-induced renal damage.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Antihypertensive Agents; Arterioles; Blood Pressure; Disease Models, Animal; Endothelins; Endothelium, Vascular; Enzyme Inhibitors; Hydralazine; Kidney; Kidney Diseases; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Sprague-Dawley; Renin-Angiotensin System; Vasoconstriction | 2010 |
Correction of endothelial dysfunction with impaza preparation in complex with enalapril and losartan during modeling of NO deficiency.
Topics: Animals; Antibodies; Enalapril; Hypertension; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Wistar | 2009 |
Impaired relaxation of cerebral arteries in the absence of elevated salt intake in normotensive congenic rats carrying the Dahl salt-sensitive renin gene.
Topics: Acetylcholine; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Animals, Congenic; Antioxidants; Blood Pressure; Captopril; Crosses, Genetic; Cyclic N-Oxides; Dose-Response Relationship, Drug; Enzyme Inhibitors; Infusions, Intravenous; Losartan; Male; Middle Cerebral Artery; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Inbred BN; Rats, Inbred Dahl; Renin; Renin-Angiotensin System; Sodium Chloride, Dietary; Spin Labels; Superoxides; Vasodilation; Vasodilator Agents | 2010 |
Pravastatin normalises peripheral cardiac sympathetic hyperactivity in the spontaneously hypertensive rat.
Topics: Animals; Blotting, Western; Cholesterol; Guanylate Cyclase; Heart Rate; Immunohistochemistry; Losartan; Male; NADPH Oxidases; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Nitric Oxide Synthase Type III; Peptidyl-Dipeptidase A; Pravastatin; Rats; Rats, Inbred SHR; Rats, Inbred WKY; Receptors, Angiotensin; Tyrosine 3-Monooxygenase | 2011 |
Involvement of the AT1 receptor in the venoconstriction induced by angiotensin II in both the inferior vena cava and femoral vein.
Topics: Angiotensin II; Animals; Femoral Vein; Imidazoles; Losartan; Male; NG-Nitroarginine Methyl Ester; Pyridines; Rats; Receptor, Angiotensin, Type 1; Vasoconstriction; Vena Cava, Inferior | 2011 |
Gadolinium increases the vascular reactivity of rat aortic rings.
Topics: Animals; Antihypertensive Agents; Aorta; Dose-Response Relationship, Drug; Enalaprilat; Endothelium, Vascular; Female; Gadolinium; Losartan; Male; NG-Nitroarginine Methyl Ester; Phenylephrine; Rats; Rats, Wistar; Vasoconstriction; Vasodilation | 2011 |
Bitter melon extracts in diabetic and normal rats favorably influence blood glucose and blood pressure regulation.
Topics: Animals; Blood Glucose; Blood Pressure; Cucurbitaceae; Diabetes Mellitus, Experimental; Fruit; Glucose Tolerance Test; Hypoglycemic Agents; Losartan; Male; Metformin; NG-Nitroarginine Methyl Ester; Nitric Oxide; Plant Extracts; Rats; Rats, Sprague-Dawley; Rats, Wistar; Renin-Angiotensin System | 2011 |
Effect of losartan, an angiotensin II type 1 receptor antagonist on cardiac autonomic functions of rats during acute and chronic inhibition of nitric oxide synthesis.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Autonomic Agents; Heart; Losartan; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Wistar; Receptor, Angiotensin, Type 1 | 2012 |
Identification of periostin as a critical marker of progression/reversal of hypertensive nephropathy.
Topics: Animals; Biomarkers; Blood Pressure; Cell Adhesion Molecules; Disease Progression; Gene Expression Regulation; Humans; Hypertension; Kidney Diseases; Kidney Transplantation; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Rats; Rats, Sprague-Dawley; Transplantation, Homologous; Vascular Diseases | 2012 |
Losartan increases muscle insulin delivery and rescues insulin's metabolic action during lipid infusion via microvascular recruitment.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Blood Pressure; Capillaries; Cells, Cultured; Endothelial Cells; Enzyme Inhibitors; Hypoglycemic Agents; Insulin; Lipids; Losartan; Male; MAP Kinase Signaling System; Microcirculation; Muscle, Skeletal; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Phosphorylation; Proto-Oncogene Proteins c-akt; Rats; Rats, Sprague-Dawley; Signal Transduction | 2013 |
Angiotensin II Type 1 receptor blockade protects endothelium-derived hyperpolarising factor-mediated relaxation in a rat model of monoarthritis.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Arteries; Arthritis, Experimental; Aspirin; Charybdotoxin; Disease Models, Animal; Dose-Response Relationship, Drug; Endothelium-Dependent Relaxing Factors; Female; Losartan; Muscle Relaxation; Muscle, Smooth, Vascular; Myography; NG-Nitroarginine Methyl Ester; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1 | 2013 |
Angiotensin II type 1 receptor blockade restores angiotensin-(1-7)-induced coronary vasodilation in hypertrophic rat hearts.
Topics: Angiotensin I; Animals; Cardiomegaly; Imidazoles; In Vitro Techniques; Losartan; Male; NG-Nitroarginine Methyl Ester; Peptide Fragments; Proto-Oncogene Mas; Proto-Oncogene Proteins; Pyridines; Rats; Receptor, Angiotensin, Type 1; Receptors, G-Protein-Coupled; Vasodilation | 2013 |
Role of angiotensin AT2 receptors and nitric oxide in the cardiopulmonary baroreflex control of renal sympathetic nerve activity in rats.
Topics: Angiotensin II; Angiotensin II Type 2 Receptor Blockers; Animals; Baroreflex; Blood Pressure; Enzyme Inhibitors; Imidazoles; Kidney; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oligopeptides; Pyridines; Rats; Rats, Wistar; Receptor, Angiotensin, Type 2; Sympathetic Nervous System | 2013 |
Chronic cadmium treatment promotes oxidative stress and endothelial damage in isolated rat aorta.
Topics: Acetophenones; Acetylcholine; Animals; Aorta; Blood Pressure; Body Weight; Cadmium; Catalase; Densitometry; Enalapril; Endothelium, Vascular; In Vitro Techniques; Losartan; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type III; Nitroprusside; Oxidative Stress; Phenylephrine; Rats; Superoxide Dismutase; Systole | 2013 |
Low-dose chronic lead exposure increases systolic arterial pressure and vascular reactivity of rat aortas.
Topics: Acetophenones; Animals; Antioxidants; Aorta; Blood Pressure; Chronic Disease; Cyclooxygenase 2 Inhibitors; Indomethacin; Lead Poisoning; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Phenylephrine; Prostaglandins; Rats; Rats, Wistar; Renin-Angiotensin System; Superoxide Dismutase; Vascular Resistance; Vasoconstriction; Vasoconstrictor Agents; Vasodilation; Vasodilator Agents | 2014 |
Elevated pressure causes endothelial dysfunction in mouse carotid arteries by increasing local angiotensin signaling.
Topics: Acetylcholine; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Animals; Blood Pressure; Captopril; Carotid Arteries; Endothelium, Vascular; Hydrazines; Hypertension; Indoles; Losartan; Male; Mice; Mice, Inbred C57BL; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type III; Reactive Oxygen Species; Signal Transduction; Tetrazoles; Valine; Valsartan; Vasodilation | 2015 |
Role of Angiotensin II type 1 receptor on renal NAD(P)H oxidase, oxidative stress and inflammation in nitric oxide inhibition induced-hypertension.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Blood Pressure; Hypertension; Inflammation; Interleukin-17; Interleukin-6; Losartan; Male; NADH, NADPH Oxidoreductases; NADPH Oxidase 4; NF-kappa B; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oxidative Stress; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1; Renin-Angiotensin System; Up-Regulation | 2015 |
Losartan and Sodium Nitroprusside Effectively Protect against Renal Impairments after Ischemia and Reperfusion in Rats.
Topics: Adenosine Triphosphatases; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Animals; Arginine; Captopril; Ischemia; Kidney; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide Donors; Nitroprusside; Peptides, Cyclic; Rats, Wistar; Renal Insufficiency; Reperfusion; Reperfusion Injury | 2015 |
The renin-angiotensin system and its vasoactive metabolite angiotensin-(1-7) in the mechanism of the healing of preexisting gastric ulcers. The involvement of Mas receptors, nitric oxide, prostaglandins and proinflammatory cytokines.
Topics: Angiotensin I; Angiotensin II; Angiotensin-Converting Enzyme Inhibitors; Animals; Cytokines; Enzyme Inhibitors; Gastric Mucosa; Imidazoles; Indomethacin; Interleukin-1beta; Lisinopril; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase; Peptide Fragments; Prostaglandins; Proto-Oncogene Mas; Proto-Oncogene Proteins; Rats; Rats, Wistar; Receptors, G-Protein-Coupled; Renin-Angiotensin System; Stomach Ulcer; Superoxide Dismutase; Tumor Necrosis Factor-alpha | 2016 |
The role of brain angiotensin II (type 2) receptors and nitric oxide in the renal sympathoinhibitory response to acute volume expansion in conscious rats.
Topics: Administration, Intravenous; Angiotensin II; Angiotensin II Type 1 Receptor Blockers; Angiotensin II Type 2 Receptor Blockers; Animals; Arterial Pressure; Body Fluids; Brain; Enzyme Inhibitors; Heart Rate; Imidazoles; Infusions, Intraventricular; Kidney; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Oligopeptides; Pyridines; Rats; Receptor, Angiotensin, Type 2; Sodium Chloride; Sympathetic Nervous System | 2017 |
Dual NEP/ECE inhibition improves endothelial function in mesenteric resistance arteries of 32-week-old SHR.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Benzazepines; Bosentan; Endothelin-Converting Enzymes; Endothelium, Vascular; Enzyme Inhibitors; Hydralazine; Hypertension; Losartan; Mesenteric Arteries; Muscle Contraction; Neprilysin; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type III; Protease Inhibitors; Rats; Rats, Inbred SHR; Sulfonamides; Vascular Resistance | 2017 |
Nitric oxide pathway presumably does not contribute to antianxiety and memory retrieval effects of losartan.
Topics: Angiotensins; Animals; Anti-Anxiety Agents; Behavior, Animal; Hypertension; Hypothalamo-Hypophyseal System; Imidazoles; Kidney; Losartan; Male; Memory; NG-Nitroarginine Methyl Ester; Nitric Oxide; Pituitary-Adrenal System; Rats; Rats, Wistar; Receptors, Angiotensin; Soluble Guanylyl Cyclase | 2017 |
Protective effect of the standardized leaf extract of Ginkgo biloba (EGb761) against hypertension-induced renal injury in rats.
Topics: Animals; Antihypertensive Agents; Arterial Pressure; Cardiovascular Agents; Ginkgo biloba; Glutathione; Hypertension; Hypertension, Renal; Interleukin-1beta; Interleukin-6; Kidney; Kidney Diseases; Losartan; Male; Malondialdehyde; NG-Nitroarginine Methyl Ester; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Oxidative Stress; Plant Extracts; Rats; Tumor Necrosis Factor-alpha | 2018 |
Interactive effects of apelin, renin-angiotensin system and nitric oxide in treatment of obesity-induced type 2 diabetes mellitus in male albino rats.
Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Apelin; Biomarkers; Blood Glucose; Diabetes Mellitus, Experimental; Diabetes Mellitus, Type 2; Diet, High-Fat; Drug Therapy, Combination; Enzyme Inhibitors; Insulin; Insulin Resistance; Losartan; Male; NG-Nitroarginine Methyl Ester; Nitric Oxide; Obesity; Rats; Renin-Angiotensin System | 2019 |
The Role of Losartan as a Potential Neuroregenerative Pharmacological Agent after Aneurysmal Subarachnoid Haemorrhage.
Topics: Animals; Basilar Artery; Disease Models, Animal; Endothelin-1; Losartan; Male; NG-Nitroarginine Methyl Ester; Rats; Rats, Sprague-Dawley; Receptor, Endothelin B; Regenerative Medicine; Subarachnoid Hemorrhage; Vasoconstriction; Vasodilation; Vasodilator Agents; Vasospasm, Intracranial | 2020 |
The Possible Regulatory Mechanisms of Aqueous, Ethyl Acetate and NHexane Fractions of the Ribes khorassanicum Extract on Acute Hypertension in Rats.
Topics: Acetates; Acute Disease; Angiotensin II; Animals; Antihypertensive Agents; Blood Pressure; Cardiovascular System; Disease Models, Animal; Hexanes; Hypertension; Losartan; Male; NG-Nitroarginine Methyl Ester; Plant Extracts; Rats; Rats, Wistar; Ribes; Signal Transduction; Water | 2021 |
Renoprotective and therapeutic effects of newly water, ethanol, and butanol ginseng fractions in hypertensive and chronic kidney disease with L-NAME.
Topics: Animals; Butanols; Disease Models, Animal; Ethanol; Female; Gas Chromatography-Mass Spectrometry; Gene Expression Regulation; Hypertension; Losartan; NG-Nitroarginine Methyl Ester; Panax; Plant Extracts; Rats; Renal Insufficiency, Chronic; Tumor Necrosis Factor-alpha; Water | 2021 |
Co-administration of metformin and/or glibenclamide with losartan reverse N
Topics: Animals; Antihypertensive Agents; Blood Pressure; Diabetes Mellitus, Experimental; Esters; Glyburide; Hypertension; Hypoglycemic Agents; Losartan; Metformin; NG-Nitroarginine Methyl Ester; Rats; Streptozocin; Water | 2023 |