losartan and metoprolol

losartan has been researched along with metoprolol in 39 studies

Research

Studies (39)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	4 (10.26)	18.2507
2000's	10 (25.64)	29.6817
2010's	22 (56.41)	24.3611
2020's	3 (7.69)	2.80

Authors

Authors	Studies
Funakoshi, J; Kakumoto, M; Okumura, K; Sakaeda, T; Takara, K; Tanigawara, Y	1
Benz, RD; Contrera, JF; Kruhlak, NL; Matthews, EJ; Weaver, JL	1
Lombardo, F; Obach, RS; Waters, NJ	1
Chupka, J; El-Kattan, A; Feng, B; Miller, HR; Obach, RS; Troutman, MD; Varma, MV	1
Barnes, JC; Bradley, P; Day, NC; Fourches, D; Reed, JZ; Tropsha, A	1
Chang, G; El-Kattan, A; Miller, HR; Obach, RS; Rotter, C; Steyn, SJ; Troutman, MD; Varma, MV	1
Avdeef, A; Tam, KY	1
Chen, M; Hu, C; Suzuki, A; Thakkar, S; Tong, W; Yu, K	1
Hasegawa, S; Imai, S; Kanda, T; Kobayashi, I; Ma, H; Matsuzaki, S; Nakano, M; Suzuki, T	1
Karjalainen, L; Laakso, M; Lempiäinen-Kuosa, P	1
Kees, F; Krämer, BK; Kurtz, A; Wagner, C	1
Irlbeck, M; Iwai, T; Zimmer, HG	1
Ushkvarok, LB	1
Baruch, L; Kunamneni, P	1
Weber, MA	1
de Santi, GL; Maciel, BC; Marin-Neto, JA; O'Connell, JL; Romano, MM; Simões, MV	1
Baskurt, M; Kaya, A; Kucukoglu, S; Okcun, B; Ortak, K; Yigit, Z; Yildiz, A	1
Chandurkar, NB; Gupta, BS; Pareek, A; Sharma, R; Tiwari, D	1
Kerkelä, R; Kubin, AM; Leskinen, H; Pieviläinen, O; Ruskoaho, H; Serpi, R; Soini, Y; Tenhunen, O; Tolonen, AM; Vaskivuo, T	1
Handler, J	1
Giraldo-Giraldo, C; Machado-Alba, JE; Moncada-Escobar, JC	1
Balestra, B; Bianchetti, MG; Esposito, F; Galfetti, M; Lava, SA	1
Günzel, C; Marx, N; Mischke, K; Noor-Ebad, F; Rana, OR; Saygili, E; Schauerte, P; Schwinger, RH	1
Amidon, GL; Dahan, A; Lennernäs, H	1
Bakris, G; Briasoulis, A; Flynn, C; Kalaitzidis, R; Lazich, I; Oliva, R; Schlaffer, C	1
Ahonen, R; Hartikainen, S; Koponen, M; Taipale, H; Tanskanen, A; Tiihonen, J; Tolppanen, AM	1
Balderia, PG; Patel, M; Stanek, M; Wongrakpanich, S	1
Berger, B; Derungs, A; Donzelli, M; Haschke, M; Krähenbühl, S; Noppen, C	1
Aro, J; Kelloniemi, A; Koivisto, E; Mustonen, E; Näpänkangas, J; Ruskoaho, H; Rysä, J	1
Bacchiani, G; Beggiato, M; Cardinale, D; Casiraghi, M; Cipolla, CM; Civelli, M; Colombo, A; Colombo, N; Lamantia, G; Meroni, CA; Salvatici, M; Sandri, MT; Spaggiari, L; Tedeschi, I; Veglia, F; Venturino, M	1
Kotegawa, T; Koya, Y; Machi, Y; Namiki, N; Shobu, Y; Uchida, S	1
Bongartz, LG; Braam, B; Cheng, C; Cramer, MJ; Doevendans, PA; Gaillard, CA; Goldschmeding, R; Joles, JA; Oosterhuis, NR; van Koppen, A; Verhaar, MC; Xu, YJ	1
Gawlak, M; Huc, T; Skrzypecki, J; Szulczyk, P; Ufnal, M	1
Jan, SU; Khan, GM; Khan, KA; Mehsud, S; Rehman, A	1
Chamorro-Pareja, N; Chirilă, RM; Marin-Acevedo, JA	1
Cintra, MACT; Coelho, EB; Cusinato, DAC; Filgueira, GCO; Lanchote, VL; Rocha, A	1
Adumekwe, CW; Agomuo, EN; Amadi, PU	1
Glick, A; Johnson, C; Sista, V	1
Agra, RM; Almengló, C; Álvarez, E; Couselo-Seijas, M; Eiras, S; García-Acuña, JM; González-Juanatey, JR; González-Peteiro, M; Varela-Román, A	1

Reviews

5 review(s) available for losartan and metoprolol

Article	Year
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans. Drug discovery today, 2016, Volume: 21, Issue:4 Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Preparations; Risk	2016
Beta-blockers in heart failure: is more better? Current heart failure reports, 2004, Volume: 1, Issue:2 Topics: Adrenergic beta-Antagonists; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Carbazoles; Carvedilol; Dose-Response Relationship, Drug; Heart Failure; Humans; Losartan; Metoprolol; Propanolamines; Prospective Studies; Randomized Controlled Trials as Topic; Renin-Angiotensin System; Sympathetic Nervous System	2004
The role of the new beta-blockers in treating cardiovascular disease. American journal of hypertension, 2005, Volume: 18, Issue:12 Pt 2 Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Aged; Antihypertensive Agents; Atenolol; Benzopyrans; Cardiovascular Diseases; Clinical Trials as Topic; Enalapril; Ethanolamines; Female; Heart Failure; Hemodynamics; Humans; Hypertension; Labetalol; Losartan; Male; Metoprolol; Middle Aged; Nebivolol; Nifedipine; Receptors, Adrenergic, beta-1; Receptors, Adrenergic, beta-2; Sympathomimetics	2005
Cardiac sarcoidosis: Case presentation and Review of the literature. Romanian journal of internal medicine = Revue roumaine de medecine interne, 2019, Mar-01, Volume: 57, Issue:1 Topics: Cardiomyopathies; Cardiovascular Agents; Drug Therapy, Combination; Female; Humans; Immunosuppressive Agents; Losartan; Methotrexate; Metoprolol; Middle Aged; Prednisone; Sarcoidosis	2019
Modulatory properties of cardiac and quercetin glycosides from Dacryodes edulis seeds during L-NAME-induced vascular perturbation. Journal of basic and clinical physiology and pharmacology, 2020, Jul-11, Volume: 31, Issue:5 Topics: Animals; Biomarkers; Burseraceae; Cardiac Glycosides; Dose-Response Relationship, Drug; Drug Synergism; Endothelium, Vascular; Losartan; Male; Metoprolol; Mice; NG-Nitroarginine Methyl Ester; Plant Extracts; Quercetin; Rats; Seeds	2020

Trials

6 trial(s) available for losartan and metoprolol

Article	Year
Effects of losartan on insulin sensitivity in hypertensive subjects. Hypertension (Dallas, Tex. : 1979), 1996, Volume: 28, Issue:3 Topics: Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Double-Blind Method; Fatty Acids, Nonesterified; Female; Glucose Clamp Technique; Glucose Tolerance Test; Humans; Hyperglycemia; Hypertension; Imidazoles; Insulin; Insulin Resistance; Lactic Acid; Lipids; Losartan; Male; Metoprolol; Middle Aged; Potassium; Tetrazoles	1996
Comparison of rate and rhythm control in hypertension patients with atrial fibrillation. Circulation journal : official journal of the Japanese Circulation Society, 2008, Volume: 72, Issue:5 Topics: Adrenergic beta-Antagonists; Aged; Angiotensin II Type 1 Receptor Blockers; Angiotensin-Converting Enzyme Inhibitors; Atrial Fibrillation; Calcium Channel Blockers; Cardiotonic Agents; Digoxin; Electric Countershock; Female; Follow-Up Studies; Humans; Hypertension; Losartan; Male; Metoprolol; Middle Aged; Survival Analysis; Treatment Outcome; Verapamil	2008
Efficacy and tolerability of a fixed-dose combination of metoprolol extended release/amlodipine in patients with mild-to-moderate hypertension: a randomized, parallel-group, multicentre comparison with losartan plus amlodipine. Clinical drug investigation, 2010, Volume: 30, Issue:2 Topics: Adolescent; Adrenergic beta-Antagonists; Adult; Aged; Amlodipine; Angiotensin II Type 1 Receptor Blockers; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Drug Combinations; Electrolytes; Female; Heart Rate; Humans; Losartan; Male; Metoprolol; Middle Aged; Young Adult	2010
Effects of nebivolol on aortic compliance in patients with diabetes and maximal renin angiotensin system blockade: the EFFORT study. Journal of clinical hypertension (Greenwich, Conn.), 2013, Volume: 15, Issue:7 Topics: Adrenergic beta-1 Receptor Antagonists; Aged; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme Inhibitors; Aorta; Benzopyrans; Black or African American; Blood Pressure; Comorbidity; Diabetes Mellitus, Type 2; Ethanolamines; Female; Heart Rate; Hemodynamics; Humans; Hypertension; Lisinopril; Losartan; Male; Metoprolol; Middle Aged; Nebivolol; Renin-Angiotensin System; Treatment Outcome	2013
Effects of Cytochrome P450 Inhibition and Induction on the Phenotyping Metrics of the Basel Cocktail: A Randomized Crossover Study. Clinical pharmacokinetics, 2016, Volume: 55, Issue:1 Topics: Adult; Alkynes; Benzoxazines; Caffeine; Cross-Over Studies; Cyclopropanes; Cytochrome P-450 Enzyme Inhibitors; Genotype; Humans; Losartan; Male; Metoprolol; Midazolam; Omeprazole; Phenotype; Young Adult	2016
Prevention of Atrial Fibrillation in High-risk Patients Undergoing Lung Cancer Surgery: The PRESAGE Trial. Annals of surgery, 2016, Volume: 264, Issue:2 Topics: Aged; Anti-Arrhythmia Agents; Atrial Fibrillation; Female; Humans; Incidence; Losartan; Lung Neoplasms; Male; Metoprolol; Middle Aged; Natriuretic Peptide, Brain; Peptide Fragments; Pneumonectomy; Postoperative Complications; Prospective Studies	2016

Other Studies

28 other study(ies) available for losartan and metoprolol

Article	Year
Interaction of digoxin with antihypertensive drugs via MDR1. Life sciences, 2002, Feb-15, Volume: 70, Issue:13 Topics: Animals; Antihypertensive Agents; ATP Binding Cassette Transporter, Subfamily B, Member 1; Biological Transport; Cells, Cultured; Digoxin; Drug Interactions; Humans; Time Factors	2002
Assessment of the health effects of chemicals in humans: II. Construction of an adverse effects database for QSAR modeling. Current drug discovery technologies, 2004, Volume: 1, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Artificial Intelligence; Computers; Databases, Factual; Drug Prescriptions; Drug-Related Side Effects and Adverse Reactions; Endpoint Determination; Models, Molecular; Quantitative Structure-Activity Relationship; Software; United States; United States Food and Drug Administration	2004
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds. Drug metabolism and disposition: the biological fate of chemicals, 2008, Volume: 36, Issue:7 Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding	2008
Physicochemical determinants of human renal clearance. Journal of medicinal chemistry, 2009, Aug-13, Volume: 52, Issue:15 Topics: Humans; Hydrogen Bonding; Hydrogen-Ion Concentration; Hydrophobic and Hydrophilic Interactions; Kidney; Metabolic Clearance Rate; Molecular Weight	2009
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species. Chemical research in toxicology, 2010, Volume: 23, Issue:1 Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLINE; Mice; Models, Chemical; Molecular Conformation; Quantitative Structure-Activity Relationship	2010
Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination. Journal of medicinal chemistry, 2010, Feb-11, Volume: 53, Issue:3 Topics: Administration, Oral; Biological Availability; Humans; Intestinal Absorption; Pharmaceutical Preparations	2010
How well can the Caco-2/Madin-Darby canine kidney models predict effective human jejunal permeability? Journal of medicinal chemistry, 2010, May-13, Volume: 53, Issue:9 Topics: Animals; Disease Models, Animal; Dogs; Humans; Jejunal Diseases; Kidney Diseases; Models, Biological; Permeability; Porosity; Regression Analysis	2010
Effect of losartan, an AT1 selective angiotensin II receptor antagonist, on isoproterenol-induced cardiac ornithine decarboxylase activity. Research communications in molecular pathology and pharmacology, 1995, Volume: 88, Issue:1 Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Biphenyl Compounds; Heart; Imidazoles; In Vitro Techniques; Isoproterenol; Losartan; Metoprolol; Myocardium; Nephrectomy; Ornithine Decarboxylase; Ornithine Decarboxylase Inhibitors; Putrescine; Rats; Rats, Wistar; Tetrazoles	1995
Role of sympathetic nerves for the stimulation of the renin system by angiotensin II receptor blockade. Journal of hypertension, 1997, Volume: 15, Issue:12 Pt 1 Topics: Adrenergic beta-Antagonists; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Blood Pressure; Catecholamines; Denervation; Kidney; Losartan; Male; Metoprolol; Rats; Rats, Sprague-Dawley; Renin; RNA, Messenger; Sympathetic Nervous System	1997
Measurement of left ventricular maximal isovolumetric pressure in rats: effects of antihypertensive drugs and diabetes mellitus. Basic research in cardiology, 1998, Volume: 93, Issue:1 Topics: Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Blood Pressure Determination; Calcium Channel Blockers; Catheterization; Diabetes Mellitus, Experimental; Female; Losartan; Metoprolol; Nifedipine; Prazosin; Rats; Rats, Sprague-Dawley; Reproducibility of Results; Ventricular Function, Left; Ventricular Pressure	1998
[Stability of neurohumoral effects of losartan combined with metoprolol in chronic cardiac low output]. Likars'ka sprava, 2002, Issue:7 Topics: Adrenergic beta-Antagonists; Angiotensin Receptor Antagonists; Cardiac Output, Low; Chronic Disease; Drug Therapy, Combination; Humans; Losartan; Metoprolol; Middle Aged; Mineralocorticoid Receptor Antagonists; Receptors, Neurotransmitter; Severity of Illness Index; Treatment Outcome	2002
Transient left ventricular dysfunction due to stress-induced cardiomyopathy. Arquivos brasileiros de cardiologia, 2007, Volume: 89, Issue:4 Topics: Acute Coronary Syndrome; Adrenergic beta-Antagonists; Aged; Angiotensin II Type 1 Receptor Blockers; Cardiomyopathies; Diagnosis, Differential; Female; Humans; Losartan; Metoprolol; Stress, Psychological; Ventricular Dysfunction, Left	2007
Divergent effects of losartan and metoprolol on cardiac remodeling, c-kit+ cells, proliferation and apoptosis in the left ventricle after myocardial infarction. Clinical and translational science, 2009, Volume: 2, Issue:6 Topics: Animals; Antihypertensive Agents; Apoptosis; Cell Count; Cell Proliferation; Heart Ventricles; Interleukin-1beta; Losartan; Metoprolol; Myocardial Infarction; Neovascularization, Pathologic; Proto-Oncogene Proteins c-kit; Rats; Ventricular Function, Left; Ventricular Remodeling	2009
Resistant hypertension responding to change from furosemide to thiazide: understanding calcium channel blocker-related edema. Journal of clinical hypertension (Greenwich, Conn.), 2010, Volume: 12, Issue:12 Topics: Adrenergic beta-1 Receptor Antagonists; Aged; Blood Pressure; Calcium Channel Blockers; Drug Therapy, Combination; Edema; Furosemide; Humans; Hypertension; Losartan; Male; Metoprolol; Sodium Chloride Symporter Inhibitors; Treatment Outcome	2010
[Active pharmacosurveillance of patients affiliated to the Colombian general social security/health system]. Revista de salud publica (Bogota, Colombia), 2010, Volume: 12, Issue:4 Topics: Adverse Drug Reaction Reporting Systems; Calcium Channel Blockers; Clopidogrel; Colombia; Diphosphonates; Drug Interactions; Drug-Related Side Effects and Adverse Reactions; Humans; Imidazoles; Losartan; Medication Systems; Metoprolol; National Health Programs; Omeprazole; Retrospective Studies; Social Security; Software; Ticlopidine; Zoledronic Acid	2010
Fetopathy probably associated to self-medication with a blocker of the renin-angiotensin system. Archives of gynecology and obstetrics, 2011, Volume: 284, Issue:5 Topics: Adrenergic beta-Antagonists; Adult; Angiotensin II Type 1 Receptor Blockers; Antimalarials; Cesarean Section; Female; Fetal Growth Retardation; Humans; Hydroxychloroquine; Infant, Newborn; Kidney; Losartan; Lupus Erythematosus, Systemic; Male; Metoprolol; Oligohydramnios; Pregnancy; Renin-Angiotensin System; Self Medication; Ultrasonography	2011
Irregular electrical activation of intrinsic cardiac adrenergic cells increases catecholamine-synthesizing enzymes. Biochemical and biophysical research communications, 2011, Sep-30, Volume: 413, Issue:3 Topics: Animals; Calcineurin Inhibitors; Catecholamines; Coculture Techniques; Cyclosporine; Dopamine beta-Hydroxylase; Electric Stimulation; Endothelin A Receptor Antagonists; Epinephrine; Losartan; Metoprolol; Myocardium; Myocytes, Cardiac; NFATC Transcription Factors; Peptides, Cyclic; Rats; Signal Transduction; Tacrolimus; Tyrosine 3-Monooxygenase	2011
The fraction dose absorbed, in humans, and high jejunal human permeability relationship. Molecular pharmaceutics, 2012, Jun-04, Volume: 9, Issue:6 Topics: Humans; Intestinal Absorption; Isotretinoin; Jejunum; Losartan; Metoprolol; Models, Biological	2012
From prescriptions to drug use periods - things to notice. BMC research notes, 2014, Nov-14, Volume: 7 Topics: Alzheimer Disease; Citalopram; Diuretics; Dose-Response Relationship, Drug; Drug Labeling; Drug Prescriptions; Humans; Losartan; Metoprolol; Pharmaceutical Preparations; Tablets; Temazepam; Time Factors	2014
Healing the orphaned heart: heart failure in a patient with glucose-6-phosphate dehydrogenase deficiency. BMJ case reports, 2015, Mar-05, Volume: 2015 Topics: Aged; Diuretics; Drug Therapy, Combination; Ethacrynic Acid; Female; Glucosephosphate Dehydrogenase Deficiency; Heart Failure; Humans; Losartan; Metoprolol; Spironolactone	2015
TSC-22 up-regulates collagen 3a1 gene expression in the rat heart. BMC cardiovascular disorders, 2015, Oct-13, Volume: 15 Topics: Animals; Antihypertensive Agents; Cells, Cultured; Collagen Type III; Female; Gene Expression; Gene Transfer Techniques; Heart Failure; Hypertension; Losartan; Male; Metoprolol; Muscle Cells; Myocardial Infarction; Myocardium; Rats, Inbred SHR; Rats, Inbred WKY; Rats, Sprague-Dawley; Repressor Proteins; RNA, Messenger; Signal Transduction; Up-Regulation; Ventricular Remodeling	2015
Prediction of drug interaction between oral adsorbent AST-120 and concomitant drugs based on the in vitro dissolution and in vivo absorption behavior of the drugs. European journal of clinical pharmacology, 2016, Volume: 72, Issue:11 Topics: Administration, Oral; Adsorption; Aluminum Hydroxide; Amlodipine; Aspirin; Carbon; Drug Interactions; Glycine; Humans; Intestinal Absorption; Losartan; Magnesium; Metoprolol; Models, Biological; Nifedipine; Oxides; Renal Insufficiency, Chronic; Solubility; Triazolam	2016
Targeting multiple pathways reduces renal and cardiac fibrosis in rats with subtotal nephrectomy followed by coronary ligation. Acta physiologica (Oxford, England), 2017, Volume: 220, Issue:3 Topics: Angiotensin II Type 1 Receptor Blockers; Animals; Antioxidants; Cardio-Renal Syndrome; Coronary Vessels; Cyclic N-Oxides; Disease Models, Animal; Drug Evaluation, Preclinical; Drug Therapy, Combination; Fibrosis; Heart; Kidney; Kidney Function Tests; Ligation; Losartan; Male; Metoprolol; Molsidomine; Nephrectomy; NF-kappa B; Nitric Oxide Donors; Pyrrolidines; Rats, Inbred Lew; Spin Labels; Sympatholytics; Thiocarbamates	2017
Renal denervation decreases blood pressure and renal tyrosine hydroxylase but does not augment the effect of hypotensive drugs. Clinical and experimental hypertension (New York, N.Y. : 1993), 2017, Volume: 39, Issue:3 Topics: Animals; Antihypertensive Agents; Arterial Pressure; Hypertension; Indapamide; Losartan; Male; Metoprolol; Rats; Rats, Inbred SHR; Renal Artery; Sympathectomy; Sympathetic Nervous System; Tyrosine 3-Monooxygenase	2017
Formulation and in vitro evaluation of directly compressed controlled release tablets designed from the Co-precipitates. Pakistan journal of pharmaceutical sciences, 2018, Volume: 31, Issue:2 Topics: Acrylates; Acrylic Resins; Delayed-Action Preparations; Drug Evaluation, Preclinical; Drug Liberation; Losartan; Metoprolol; Tablets	2018
LC-MS/MS analysis of the plasma concentrations of a cocktail of 5 cytochrome P450 and P-glycoprotein probe substrates and their metabolites using subtherapeutic doses. Journal of pharmaceutical and biomedical analysis, 2019, Feb-05, Volume: 164 Topics: Adult; ATP Binding Cassette Transporter, Subfamily B; Biological Variation, Population; Caffeine; Chromatography, High Pressure Liquid; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP2C9; Cytochrome P-450 CYP2D6; Healthy Volunteers; Humans; Isoenzymes; Losartan; Male; Metoprolol; Midazolam; Omeprazole; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization; Tandem Mass Spectrometry; Terfenadine	2019
Oral Manifestations of Commonly Prescribed Drugs. American family physician, 2020, 11-15, Volume: 102, Issue:10 Topics: Albuterol; Amlodipine; Anticonvulsants; Antihypertensive Agents; Atorvastatin; Bisphosphonate-Associated Osteonecrosis of the Jaw; Bronchodilator Agents; Deprescriptions; Drug Hypersensitivity; Fluorides; Gingival Overgrowth; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Hyperpigmentation; Hypoglycemic Agents; Lisinopril; Losartan; Metformin; Metoprolol; Mouth Diseases; Omeprazole; Oral Hygiene; Proton Pump Inhibitors; Simvastatin; Thyroxine; Toothpastes; Xerostomia	2020
Soluble angiotensin-converting enzyme levels in heart failure or acute coronary syndrome: revisiting its modulation and prognosis value. Journal of molecular medicine (Berlin, Germany), 2021, Volume: 99, Issue:12 Topics: Acute Coronary Syndrome; ADAM17 Protein; Adrenergic beta-Antagonists; Aged; Aged, 80 and over; Angiotensin II; Angiotensin Receptor Antagonists; Angiotensin-Converting Enzyme 2; Enalapril; Female; Heart Failure; Human Umbilical Vein Endothelial Cells; Humans; Kaplan-Meier Estimate; Losartan; Male; Metoprolol; Middle Aged; Peptidyl-Dipeptidase A; Prognosis	2021